kidney function tests


Top Publications

  1. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  2. ncbi Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Kidney Dis 40:221-6. 2002
  3. pmc Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:395-406. 2008
  4. ncbi Modification of the CKD epidemiology collaboration (CKD-EPI) equation for Japanese: accuracy and use for population estimates
    Masaru Horio
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Kidney Dis 56:32-8. 2010
  5. ncbi Prevalence of kidney damage in Australian adults: The AusDiab kidney study
    Steven J Chadban
    Department of Nephrology, Monash Medical Centre, USA
    J Am Soc Nephrol 14:S131-8. 2003
  6. pmc Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2
    Lesley A Stevens
    Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 56:486-95. 2010
  7. pmc Urinary neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury after orthotopic liver transplantation
    Gebhard Wagener
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Nephrol Dial Transplant 26:1717-23. 2011
  8. ncbi Report of the Radionuclides in Nephrourology Committee on renal clearance
    M D Blaufox
    Department of Nuclear Medicine, Montefiore Medical Park, Bronx, New York 10461, USA
    J Nucl Med 37:1883-90. 1996
  9. ncbi Worsening renal function and prognosis in heart failure: systematic review and meta-analysis
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Card Fail 13:599-608. 2007
  10. ncbi Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children--a meta-analysis
    Juliana F Roos
    School of Pharmacy, University of Queensland, Brisbane, QLD 4072, Australia
    Clin Biochem 40:383-91. 2007

Detail Information

Publications278 found, 100 shown here

  1. ncbi Assessing kidney function--measured and estimated glomerular filtration rate
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, Boston, MA 02111, USA
    N Engl J Med 354:2473-83. 2006
  2. ncbi Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis
    Vikas R Dharnidharka
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Am J Kidney Dis 40:221-6. 2002
    ..However, there are conflicting reports regarding the superiority of Cys C over serum creatinine (Cr), with a few studies suggesting no significant difference...
  3. pmc Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD
    Lesley A Stevens
    Division of Nephrology, Tufts New England Medical Center, 750 Washington St, Box 391, Boston, MA 02111, USA
    Am J Kidney Dis 51:395-406. 2008
    ..We report the development and evaluation of GFR-estimating equations using serum cystatin C alone and serum cystatin C, serum creatinine, or both with demographic variables...
  4. ncbi Modification of the CKD epidemiology collaboration (CKD-EPI) equation for Japanese: accuracy and use for population estimates
    Masaru Horio
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Kidney Dis 56:32-8. 2010
    ..We modified the CKD-EPI equation for use in Japan, compared its accuracy with the Japanese modification of the MDRD Study equation, and compared the prevalence of CKD in Japan using both equations...
  5. ncbi Prevalence of kidney damage in Australian adults: The AusDiab kidney study
    Steven J Chadban
    Department of Nephrology, Monash Medical Centre, USA
    J Am Soc Nephrol 14:S131-8. 2003
    ..Identifying and targeting this section of the population may provide a means to reduce the burden of ESRD...
  6. pmc Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2
    Lesley A Stevens
    Tufts Medical Center, Boston, MA 02111, USA
    Am J Kidney Dis 56:486-95. 2010
    ..Here, performance of a more accurate GFR-estimating equation, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, is reported by level of GFR and clinical characteristics...
  7. pmc Urinary neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury after orthotopic liver transplantation
    Gebhard Wagener
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Nephrol Dial Transplant 26:1717-23. 2011
    ..It predicts acute kidney injury (AKI) in multiple clinical scenarios. We hypothesized that urinary NGAL can predict AKI after liver transplantation...
  8. ncbi Report of the Radionuclides in Nephrourology Committee on renal clearance
    M D Blaufox
    Department of Nuclear Medicine, Montefiore Medical Park, Bronx, New York 10461, USA
    J Nucl Med 37:1883-90. 1996
    ..This report is meant to provide guidance to those centers that would like to initiate clearance procedures but have difficulty in choosing appropriate methodology...
  9. ncbi Worsening renal function and prognosis in heart failure: systematic review and meta-analysis
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Card Fail 13:599-608. 2007
    ..The present study was designed to establish the proportion of patients with HF that exhibits (WRF) and the associated risk for mortality and hospitalization by conducting a systematic review and meta-analysis...
  10. ncbi Diagnostic accuracy of cystatin C compared to serum creatinine for the estimation of renal dysfunction in adults and children--a meta-analysis
    Juliana F Roos
    School of Pharmacy, University of Queensland, Brisbane, QLD 4072, Australia
    Clin Biochem 40:383-91. 2007
    ..To perform a systematic review comparing the diagnostic accuracy of CysC with SCr...
  11. ncbi Factors other than glomerular filtration rate affect serum cystatin C levels
    Lesley A Stevens
    Division of Nephrology, Clinical Care Research, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 75:652-60. 2009
    ..Hence, we found that cystatin C is affected by factors other than GFR which should be considered when the GFR is estimated using serum levels of cystatin C...
  12. ncbi Measured GFR as a confirmatory test for estimated GFR
    Lesley A Stevens
    Tufts Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:2305-13. 2009
    ..We suggest plasma clearance of nonradioactive markers be more widely implemented in clinical settings. Further research is necessary on the impact of the use of measured GFR as a confirmatory test...
  13. ncbi Association between renal function and circulating levels of natriuretic peptides (from the Dallas Heart Study)
    Sandeep R Das
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Cardiol 102:1394-8. 2008
    ..With eGFR <90 ml/min/1.73 m(2), both NT-pro-BNP and BNP were inversely and independently associated with renal function, with a greater magnitude of association with renal impairment noted for NT-pro-BNP...
  14. ncbi Developing a consensus classification system for acute renal failure
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Curr Opin Crit Care 8:509-14. 2002
    ..Recommendations for validating a classification system are also considered...
  15. ncbi High rate of reversibility of renal damage in a cohort of HIV-infected patients receiving tenofovir-containing antiretroviral therapy
    Anna Bonjoch
    Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Autonomous University, Barcelona, Spain
    Antiviral Res 96:65-9. 2012
  16. ncbi Neutrophil gelatinase--associated lipocalin predicts acute kidney injury in patients undergoing liver transplantation
    Andrew J Portal
    Institute of Liver Studies, Denmark Hill, London, England
    Liver Transpl 16:1257-66. 2010
    ..In conclusion, a combination of NGAL and APACHE II predicts AKI with high sensitivity and specificity after LT...
  17. pmc Comparative effects of low-carbohydrate high-protein versus low-fat diets on the kidney
    Allon N Friedman
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin J Am Soc Nephrol 7:1103-11. 2012
    ..Concerns exist about deleterious renal effects of low-carbohydrate high-protein weight loss diets. This issue was addressed in a secondary analysis of a parallel randomized, controlled long-term trial...
  18. pmc Relation of systemic and urinary neutrophil gelatinase-associated lipocalin levels to different aspects of impaired renal function in patients with acute decompensated heart failure
    Kevin Shrestha
    Heart and Vascular Institute, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Cardiol 110:1329-35. 2012
    ..Both systemic and urine NGAL predict worsening renal function...
  19. pmc High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up
    Linda H Ficociello
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 33:1337-43. 2010
    ..Here, we prospectively investigated whether baseline uric acid impacts the risk of early progressive renal function loss (early GFR loss) in these patients...
  20. ncbi Enzyme replacement therapy with agalsidase alfa in patients with Fabry's disease: an analysis of registry data
    A Mehta
    University College London, London, UK
    Lancet 374:1986-96. 2009
    ..We analysed 5-year treatment with agalsidase alfa enzyme replacement therapy in patients with Fabry's disease who were enrolled in the Fabry Outcome Survey observational database (FOS)...
  21. pmc The assessment of renal function in relation to the use of drugs in elderly in nursing homes; a cohort study
    Sara Modig
    Department of Clinical Sciences in Malmo, Center for Primary Health Care Research, Lund University, Sweden
    BMC Geriatr 11:1. 2011
    ..The aim of the study was to explore renal function in elderly subjects in nursing homes and the use of pharmaceuticals that may be harmful to patients with renal impairment...
  22. pmc Renal outcomes of agalsidase beta treatment for Fabry disease: role of proteinuria and timing of treatment initiation
    David G Warnock
    University of Alabama at Birmingham, Birmingham, AL, USA
    Nephrol Dial Transplant 27:1042-9. 2012
    ..The purpose of this study was to identify determinants of renal disease progression in adults with Fabry disease during treatment with agalsidase beta...
  23. ncbi Cystatin C-based equations in renal transplantation: moving toward a better glomerular filtration rate prediction?
    Nicolas Maillard
    Service de Nephrologie, Dialyse, Transplantation Renale, Laboratoires d Explorations Fonctionnelles Rénales, Saint Etienne, France
    Transplantation 85:1855-8. 2008
    ..95, 95% CI 0.91-1) than for the MDRD equation (0.76, 95% CI 0.67-0.85). These data confirm that cystatin C as a GFR marker offers significant advantages over creatinine in renal transplantation...
  24. ncbi Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity
    T A Ajith
    Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur, Kerala 680 555, India
    Food Chem Toxicol 46:3178-81. 2008
    ..001) in the Z. officinale (400mg/kg) plus DXN treated group. The nephroprotection is mediated by preventing the DXN-induced decline of renal antioxidant status, and also by increasing the activity of GST...
  25. ncbi Implication of CKD-EPI equation to estimate glomerular filtration rate in Chinese patients with chronic kidney disease
    Xin Du
    Department of Nephrology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, PR China
    Ren Fail 33:859-65. 2011
    ..To evaluate the applicability of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate (GFR) in Chinese patients of different stages of CKD...
  26. ncbi Evolution and predictive power of serum cystatin C in acute renal failure
    A Ahlstrom
    Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Intensive Care Unit, Helsinki University Hospital, Helsinki, Finland
    Clin Nephrol 62:344-50. 2004
    ..Little is known about cystatin C in critical illness. We assessed serum cystatin C as a marker of renal function in acute renal failure (ARF) and its power in predicting survival of ARF patients...
  27. ncbi Acute kidney injury following coronary angiography is associated with a long-term decline in kidney function
    Matthew T James
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Kidney Int 78:803-9. 2010
    ..8 ml/min following moderate to severe acute kidney injury. Thus, acute kidney injury following coronary angiography is associated with a sustained loss and a larger rate of future decline in kidney function...
  28. ncbi Improved GFR estimation by combined creatinine and cystatin C measurements
    Y C Ma
    Division of Nephrology and Institute of Nephrology, The First Hospital, Peking University, Xicheng District, Beijing, China
    Kidney Int 72:1535-42. 2007
    ..The estimated GFR combining Pcr and cysC measurements more accurately matched the reference GFR at all stages of CKD than the other equations, particularly in patients with near-normal kidney function...
  29. pmc Major contribution of tubular secretion to creatinine clearance in mice
    Christoph Eisner
    National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA
    Kidney Int 77:519-26. 2010
    ..Hence we show that there is a major secretory contribution to creatinine excretion mediated through the organic anion transport system. This feature adds to problems associated with measuring endogenous creatinine filtration in mice...
  30. ncbi Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury
    Raghu Kempegowda Tadagavadi
    Division of Nephrology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Immunol 185:3750-8. 2010
    ..Our studies demonstrate that netrin-1 acting through UNC5B receptor reduces renal ischemia-reperfusion injury and its associated renal inflammation...
  31. pmc Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney
    Weiwei Wang
    Division of Nephrology, H040, Pennsylvania State Univ College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 294:F739-47. 2008
    ..These results suggest that downregulation of netrin-1 in vascular endothelial cells may promote endothelial cell activation and infiltration of leukocytes into the kidney thereby enhancing tubular injury...
  32. pmc Prevalence and factors associated with renal dysfunction among HIV-infected patients
    Nancy Crum-Cianflone
    HIV Clinic, Naval Medical Center San Diego, San Diego, California 92134 1005, USA
    AIDS Patient Care STDS 24:353-60. 2010
    ..Consideration for more frequent monitoring of kidney function among these select HIV patients may be warranted...
  33. ncbi Rapid microplate method for PAH estimation
    Rajiv Agarwal
    Division of Nephrology, Department of Medicine, Indiana University and Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 283:F236-41. 2002
    ..The microplate method is a reliable alternative to a reference HPLC method and can be performed for a fraction of the cost, time, and reagents...
  34. ncbi How to estimate GFR-serum creatinine, serum cystatin C or equations?
    Stefan Herget-Rosenthal
    Department of Nephrology, University of Duisburg Essen, Germany
    Clin Biochem 40:153-61. 2007
    ..In principle, clinicians should be aware of the limitations of and cautioned not to overrate estimated GFR by single markers or calculated by equations and should not entirely rely on GFR estimates to make precise clinical decisions...
  35. pmc Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure
    Arash Aghel
    Education Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Card Fail 16:49-54. 2010
    ..We sought to determine the relationship between admission serum NGAL levels and WRF in the setting of ADHF...
  36. ncbi The unrecognized prevalence of chronic kidney disease in diabetes
    Rachel J Middleton
    Department of Renal Medicine, Hope Hospital, Stott Lane, Salford M6 8HD, UK, and Chronic Disease Research Group and University of Minnesota, Minneapolis, USA
    Nephrol Dial Transplant 21:88-92. 2006
    ..The aim of this study was to estimate the burden of CKD in patients with diabetes and examine the ability of serum creatinine and albuminuria to detect clinically meaningful CKD compared with estimated glomerular filtration rate (eGFR)...
  37. ncbi Projecting the number of patients with end-stage renal disease in the United States to the year 2015
    David T Gilbertson
    United States Renal Data System Coordinating Center University of Minnesota, Minneapolis, MN 55404, USA
    J Am Soc Nephrol 16:3736-41. 2005
    ..The financial and human resources that will be needed to care for these patients in 2015 will be considerably greater than in 2005...
  38. pmc Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury
    Edward D Siew
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 77:536-42. 2010
    ..Our study found that commonly used surrogates for baseline serum creatinine result in bi-directional misclassification of the incidence and prognosis of acute kidney injury in a hospital setting...
  39. ncbi Mechanisms of tubulointerstitial injury in the kidney: final common pathways to end-stage renal failure
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo
    Intern Med 43:9-17. 2004
    ..This induces chronic hypoxia in this compartment, rendering a vicious cycle. Development of novel therapeutic approaches against these final common pathways will enable us to target any types of renal disease...
  40. ncbi Costs and outcomes of acute kidney injury (AKI) following cardiac surgery
    Joseph F Dasta
    College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Nephrol Dial Transplant 23:1970-4. 2008
    ..We determined costs, resource use and mortality rate of patients. We used the serum creatinine component of the RIFLE system to classify AKI...
  41. ncbi Increased blood pressure but normal renal function in adult women born preterm
    A Kistner
    Institute of Woman s and Child s Health, Karolinska Institute, Astrid Lindgren Children s Hospital Q2 09, 171 77 Stockholm, Sweden
    Pediatr Nephrol 15:215-20. 2000
    ..The objective of this study was to investigate the relationship between birth weight, blood pressure, and kidney function in adult subjects who were born preterm or born small for gestational age (SGA)...
  42. ncbi A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals
    Exing Wang
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indiana Center for Biological Microscopy, Indianapolis, Indiana 46202, USA
    Kidney Int 81:112-7. 2012
    ..Thus, our ratiometric technique allows for both measurement of plasma vascular volume and highly accurate real-time GFR determinations, enabling clinical decision making in real time...
  43. ncbi Accuracy of GFR predictive equations in renal transplantation: validation of a new turbidimetric cystatin C assay on Architect c8000
    A S Bargnoux
    Department of Biochemistry, University of Montpellier 1, Montpellier, France
    Clin Biochem 45:151-3. 2012
    ..To evaluate the Sentinel-PETIA cystatin C on Architect c8000 analyzer...
  44. ncbi Validation of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in advanced chronic renal failure
    J L Teruel Briones
    Nephrology Department, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, Madrid, Spain
    Nefrologia 31:677-82. 2011
    ..The aim of this work was to study the accuracy of the CKD-EPI equation to estimate the glomerular filtrate in patients with advanced chronic renal failure...
  45. ncbi Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir
    Pablo Labarga
    Infectious Diseases Department, Hospital Carlos III, Madrid, Spain
    AIDS 23:689-96. 2009
    ..Kidney abnormalities are the main concern using the drug. As glomerular function is infrequently affected in patients treated with TDF, herein, we report the results of an extensive examination of tubular function...
  46. ncbi Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats
    Daniel Schock-Kusch
    InnovationLab GmbH, Speyerer Str 4, D 69115 Heidelberg, Germany
    Nephrol Dial Transplant 24:2997-3001. 2009
    ..Here we describe and validate an approach for a transcutaneous determination of GFR by using fluorescein-isothiocyanate-labelled sinistrin (FITC-S) in rats...
  47. ncbi Assessment of renal function in recently admitted critically ill patients with normal serum creatinine
    Eric A J Hoste
    Intensive Care Unit, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    Nephrol Dial Transplant 20:747-53. 2005
  48. pmc Serum levels of the adipokine chemerin in relation to renal function
    Dörte Pfau
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Diabetes Care 33:171-3. 2010
    ..To investigate serum levels of the adipokine chemerin in patients on chronic hemodialysis (CD) as compared with control patients with a glomerular filtration rate (GFR) >50 ml/min...
  49. ncbi Effect of warm ischemia on renal function during partial nephrectomy: assessment with new 99mTc-mercaptoacetyltriglycine scintigraphy parameter
    Yasuhito Funahashi
    Department of Urology, Nagoya University, Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Urology 79:160-4. 2012
    ..We quantified renal function using a new 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) renal scintigraphy parameter...
  50. ncbi Subtherapeutic initial β-lactam concentrations in select critically ill patients: association between augmented renal clearance and low trough drug concentrations
    Andrew A Udy
    Department of Intensive Care Medicine, University of Queensland, Herston, Brisbane, QLD, Australia
    Chest 142:30-9. 2012
    ..Changes in renal function in this setting can significantly impact the probability of achieving such targets...
  51. ncbi Clinical features of non-diabetic renal diseases in patients with type 2 diabetes
    Atsuhito Tone
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Diabetes Res Clin Pract 69:237-42. 2005
    ..Our study confirmed that the absence of retinopathy and short duration of diabetes are useful clinical indications for renal biopsy in diabetic patients with overt proteinuria...
  52. ncbi Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients
    Giuseppe Lippi
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chimica Clinica, Universita degli Studi di Verona, Verona, Italy
    Scand J Clin Lab Invest 68:745-8. 2008
    ..However, the mechanism(s) underlying this association remains unclear. Since impaired kidney function is a well-known risk factor for cardiovascular disease, we assessed whether RDW is associated with decreased kidney function...
  53. ncbi Reporting of estimated GFR in the primary care clinic
    Christina Wyatt
    Department of Medicine, The Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Kidney Dis 49:634-41. 2007
    ..Patients with early (stage 3) CKD remain undiagnosed in primary care clinics; therefore, we hypothesized that routine reporting of eGFR in outpatient clinics would improve the recognition and treatment of CKD...
  54. pmc Estimating glomerular filtration rate: Cockcroft-Gault and Modification of Diet in Renal Disease formulas compared to renal inulin clearance
    Rossini Botev
    Hawaii Permanente Medical Group, 3288 Moanalua Road, Honolulu, Hawaii 96819, USA
    Clin J Am Soc Nephrol 4:899-906. 2009
    ..The Cockcroft-Gault (CG) and Modification of Diet in Renal Disease (MDRD) formulas are the most commonly used estimations...
  55. ncbi Once-daily prolonged-release tacrolimus (ADVAGRAF) versus twice-daily tacrolimus (PROGRAF) in liver transplantation
    P Trunecka
    Department of Hepatogastroenterology, IKEM, Prague, Czech Republic
    Am J Transplant 10:2313-23. 2010
    ..3% for tacrolimus QD. Adverse event (AE) profiles were similar for both tacrolimus BID and QD with comparable incidences of AEs and serious AEs. Tacrolimus QD was well tolerated with similar efficacy and safety profiles to tacrolimus BID...
  56. ncbi Limited warm ischemia during elective partial nephrectomy has only a marginal impact on renal functional outcomes
    Brian R Lane
    Spectrum Health and Michigan State University, Grand Rapids, Michigan, USA
    J Urol 185:1598-603. 2011
    ..The renal functional implications of these approaches have not been well studied in patients who undergo elective partial nephrectomy...
  57. ncbi Prevalence and factors associated with renal impairment in HIV-infected patients, ANRS C03 Aquitaine Cohort, France
    E K Déti
    Institut National de la Santé et de la Recherche Médicale U897, Bordeaux, F 33076, France
    HIV Med 11:308-17. 2010
    ..The aims of the present study were to estimate the prevalence of renal impairment (RI) among HIV-infected adult patients and to investigate the associated factors...
  58. ncbi Metabolomic profiling of uremic solutes in CKD patients
    Takafumi Toyohara
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 33:944-52. 2010
    ..These compounds provide diagnostic information and may be targets for therapies designed to treat the complications of CKD patients...
  59. ncbi Established and emerging markers of kidney function
    Michael A Ferguson
    Division of Nephrology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 58:680-9. 2012
    ..Several novel biomarkers of kidney injury and function are under investigation...
  60. pmc Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats
    Sandra Geschka
    Cardiology Research, Bayer HealthCare, Wuppertal, Germany
    PLoS ONE 6:e21853. 2011
    ..Little is known about their effects on tissue remodeling and degeneration and survival in experimental malignant hypertension...
  61. ncbi Early renal function post-liver transplantation is predictive of progressive chronic kidney disease
    Gustaf Herlenius
    Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Scand J Gastroenterol 43:344-9. 2008
  62. ncbi Cystatin C as a marker of glomerular filtration rate in voluntary kidney donors
    Krishnaswamy Jaisuresh
    Department of Nephrology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Exp Clin Transplant 10:14-7. 2012
    ..This study sought to assess the usefulness of serum cystatin C as a marker of glomerular filtration rate in comparison with serum creatinine and serum creatinine-based glomerular filtration rate estimations in voluntary kidney donors...
  63. ncbi Development of cardiovascular disease due to renal insufficiency in male sheep following fetal unilateral nephrectomy
    Reetu R Singh
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia
    J Hypertens 27:386-96. 2009
    ..Renal insufficiency is associated with the development of cardiovascular disease...
  64. ncbi Evaluating the performance of equations for estimating glomerular filtration rate
    Lesley A Stevens
    Tufts University School of Medicine, Tufts Medical Center, 800 Washington Street, Box 391 Boston, MA 02111, USA
    J Nephrol 21:797-807. 2008
  65. ncbi Modified diet in renal disease method overestimates renal function in selected elderly patients
    Gregory William Roberts
    Pharmacy Department, Repatriation General Hospital, Daw Park, SA 5041, Australia
    Age Ageing 38:698-703. 2009
    ..We needed to assess which renal function estimate was most suited for drug dose estimation in our population...
  66. ncbi Prospective study of progression of kidney dysfunction in community-dwelling older adults
    Ricardo Sesso
    Division of Nephrology, Department of Medicine, Escola Paulista de Medicina, Federal University of Sao Paulo, Sao Paulo, Brazil
    Nephrology (Carlton) 13:99-103. 2008
    ..Few prospective studies have assessed renal dysfunction in older persons. We sought to define kidney dysfunction among a community-based cohort of elderly subjects and to determine the factors for its progression...
  67. ncbi A clinician's guide to monitoring kidney function in lithium-treated patients
    James W Jefferson
    Department of Psychiatry, Healthcare Technology Systems, Inc, 7617 Mineral Point Rd, Ste 300, Madison, WI 53717, USA
    J Clin Psychiatry 71:1153-7. 2010
    ..This overview clarifies those practical aspects of monitoring that are often overlooked or misunderstood...
  68. ncbi Central pulse pressure and aortic stiffness determine renal hemodynamics: pathophysiological implication for microalbuminuria in hypertension
    Junichiro Hashimoto
    Department of Blood Pressure Research, Tohoku University Graduate School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Hypertension 58:839-46. 2011
    ..In conclusion, increased aortic pulse pressure causes renal microvascular damage through altered renal hemodynamics resulting from increased peripheral resistance and/or increased flow pulsation...
  69. ncbi Comparison of methods for determination of glomerular filtration rate: low and high-dose Tc-99m-DTPA renography, predicted creatinine clearance method, and plasma sample method
    Majid Assadi
    Department of Oncology and Nuclear Medicine, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Boostan 19 Alley, 7514763448, Imam Khomeini Street, Bushehr, Iran
    Int Urol Nephrol 40:1059-65. 2008
    ..Because of the low cost and negligible radiation burden, this method might be preferred for routine practice in nuclear medicine...
  70. pmc A comparison of estimates of glomerular filtration in critically ill patients with augmented renal clearance
    João Pedro Baptista
    Servico de Medicina Intensiva, Hospitais da Universidade de Coimbra, EPEPraceta Prof Mota Pinto, Av Bissaya Barreto 3000 075 Coimbra, Portugal
    Crit Care 15:R139. 2011
    ..To date, these estimates have not been rigorously validated in those with augmented clearances, resulting in potentially inaccurate drug prescription...
  71. ncbi Glomerular involvement in adults with sickle cell hemoglobinopathies: Prevalence and clinical correlates of progressive renal failure
    Antonio Guasch
    Renal Division, Emory University, Room 338, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Am Soc Nephrol 17:2228-35. 2006
    ..In contrast to other glomerulopathies, the development of systemic hypertension is uncommon in SS disease with renal insufficiency...
  72. ncbi Effects of BG9719 (CVT-124), an A1-adenosine receptor antagonist, and furosemide on glomerular filtration rate and natriuresis in patients with congestive heart failure
    S S Gottlieb
    Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
    J Am Coll Cardiol 35:56-9. 2000
    ..To determine the effects of furosemide and the selective A1 adenosine receptor BG9719 on renal function in patients with congestive heart failure (CHF)...
  73. pmc Systematic shifts in cystatin C between 2006 and 2010
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, PO Box 6511, Mail Stop A140, Aurora, CO 80045, USA
    Clin J Am Soc Nephrol 6:1952-5. 2011
    ..Our objective was to compare cystatin C results within the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study over time and in repeated measures to evaluate for assay drift...
  74. pmc Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome
    K L Andrews
    Renal Division and the Division of Pulmonary and Critical Care Medicine, The Department of Internal Medicine, The Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Pathol 157:303-11. 2000
    ..Thus, gelB does not have a discernible role in the normal kidney and gelB is not involved in the progression of glomerulonephritis in a mouse model of Alport syndrome...
  75. ncbi Association of single measurements of dipstick proteinuria, estimated glomerular filtration rate, and hematocrit with 25-year incidence of end-stage renal disease in the multiple risk factor intervention trial
    Areef Ishani
    Division of Nephrology 111J, Department of Medicine, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    J Am Soc Nephrol 17:1444-52. 2006
    ..73 m(2) were strong predictors of long-term development of ESRD. It remains unknown whether intervention for proteinuria or early identification of those with chronic kidney disease reduces the risk for ESRD...
  76. ncbi The evaluation of renal function and disease in patients with cirrhosis
    Claire Francoz
    Hepatology and Liver Intensive Care Unit, Hospital Beaujon, Clichy, France
    J Hepatol 52:605-13. 2010
    ..In candidates for transplantation, attention should therefore be focused on vascular lesions which may represent a risk factor for nephrotoxicities induced by calcineurin-inhibitors...
  77. ncbi Renal resistance index and progression of renal disease
    Jörg Radermacher
    Department of Nephrology, Hannover Medical School, Hannover, Germany
    Hypertension 39:699-703. 2002
    ..A renal resistance index value of greater-than-or-equal to 80 reliably identifies patients at risk for progressive renal disease...
  78. ncbi Association between chronic kidney disease and coronary artery calcification: the Dallas Heart Study
    Holly Kramer
    Loyola Medical Center, Department of Preventive Medicine, 2160 First Avenue, Maywood, IL 60153, USA
    J Am Soc Nephrol 16:507-13. 2005
    ..These findings need to be confirmed in study populations that include adults >65 yr of age and a larger number of CKD cases...
  79. ncbi Diabetic kidney disease in the db/db mouse
    Kumar Sharma
    Dorrance Hamilton Research Laboratory, Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Renal Physiol 284:F1138-44. 2003
    ..Furthermore, we discuss shortfalls of assessing functional renal disease in mouse models of diabetic kidney disease...
  80. ncbi Pitfalls of using estimations of glomerular filtration rate in an intensive care population
    J H Martin
    Department of Internal Medicine and Aged Care, Cancer Care Services, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Intern Med J 41:537-43. 2011
    ..Accurate knowledge of the glomerular filtration rate (GFR) is imperative in the intensive care unit (ICU) as renal status is important for medical decisions, including drug dosing...
  81. ncbi Augmented renal clearance in the Intensive Care Unit: an illustrative case series
    Andrew A Udy
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Brisbane, Queensland, Australia
    Int J Antimicrob Agents 35:606-8. 2010
    ..TDM, or at least a measured creatinine clearance, should be considered early in this setting to allow the optimisation of antibiotic exposure...
  82. ncbi Uric acid correlates with the severity of histopathological parameters in IgA nephropathy
    Juhani Myllymäki
    Medical School, University of Tampere, FIN 33014, Finland
    Nephrol Dial Transplant 20:89-95. 2005
    ..Many clinical and histopathological risk factors for progression have been found previously. Recently, metabolic risk factors, such as hyperuricaemia and hypertriglyceridaemia, also have been associated with the progression of IgAN...
  83. ncbi Fluid status in CAPD patients is related to peritoneal transport and residual renal function: evidence from a longitudinal study
    Constantijn J A M Konings
    Department of Internal Medicine and Nephrology, Academical Hospital Maastricht, The Netherlands
    Nephrol Dial Transplant 18:797-803. 2003
    ..It has been suggested that part of this relationship might be explained by an effect of both parameters on the fluid state in CAPD patients or by the relationship between inflammation and peritoneal transport...
  84. ncbi Renal resistive index and renal function before and after paracentesis in patients with hepatorenal syndrome and tense ascites
    Andreas Umgelter
    II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Ismaninger Str 22, 81675, Munich, Germany
    Intensive Care Med 35:152-6. 2009
    ..To assess the effect of reducing intra-abdominal pressure (IAP) by paracentesis on renal resistive index (RI), hemodynamics and renal function...
  85. ncbi Renal resistive index and long-term outcome in chronic nephropathies
    Claudia Parolini
    Department of Nephrology, Tor Vergata University, Viale Oxford 81, 00133 Rome, Italy
    Radiology 252:888-96. 2009
    ..To assess the clinical validity of renal resistive index (RI) to determine prognosis and guide therapy over a long-term follow-up in patients with chronic nephropathies and to verify the commonly used threshold value of 0.70...
  86. ncbi A comparison of the predictive performance of different methods of kidney function estimation in a well-characterized HIV-infected population
    Katherine Barraclough
    Division of Nephrology, University of British Columbia, Vancouver, B C, Canada
    Nephron Clin Pract 111:c39-48. 2009
    ..Glomerular filtration rate (GFR) estimation equations have never been validated in the HIV population. This pilot study aimed to compare all currently available methods of kidney function assessment with nuclear GFR in HIV-infected adults...
  87. ncbi Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis
    Marcus A Bain
    Centre for Pharmaceutical Research, University of South Australia, Adelaide, SA 5000, Australia
    Nephrol Dial Transplant 21:1300-4. 2006
    ..The clinical significance of TMA may be related to its potential to contribute to neurological toxicity and 'uraemic breath' in patients with end-stage renal disease (ESRD)...
  88. pmc Cystatin C, albuminuria, and mortality among older adults with diabetes
    Ian H De Boer
    University of Washington, Seattle, Washington, USA
    Diabetes Care 32:1833-8. 2009
    ..Joint associations of albuminuria and impaired GFR with mortality have not been comprehensively evaluated in this population...
  89. pmc Long-term safety and efficacy of enzyme replacement therapy for Fabry disease
    William R Wilcox
    Cedars Sinai Burns and Allen Research Institute and UCLA School of Medicine, Los Angeles, CA, USA
    Am J Hum Genet 75:65-74. 2004
    ..Thus, enzyme replacement therapy for 30-36 mo with agalsidase beta resulted in continuously decreased plasma GL-3 levels, sustained endothelial GL-3 clearance, stable kidney function, and a favorable safety profile...
  90. pmc Evidence that kidney function but not type 2 diabetes determines retinol-binding protein 4 serum levels
    Andrea Henze
    Department of Physiology and Pathophysiology of Nutrition, Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
    Diabetes 57:3323-6. 2008
    ..However, circulating RBP4 levels are also affected by kidney function. Therefore, the aim of this study was to test whether RBP4 serum levels are primarily associated with kidney function or type 2 diabetes...
  91. ncbi Renal function at the time of renal biopsy as a predictor of prognosis in patients with primary AL-type amyloidosis
    Yutaka Osawa
    Shinrakuen Hospital, 1 27 Nishi Ariake, Niigata 950 2087, Japan
    Clin Exp Nephrol 8:127-33. 2004
  92. ncbi Renal function--estimation of glomerular filtration rate
    Lothar Thomas
    Department of Laboratory Medicine, Krankenhaus Nordwest, Frankfurt, Germany
    Clin Chem Lab Med 44:1295-302. 2006
    ..The cystatin C prediction equation with the use of a prepubertal factor seems superior to creatinine-based prediction equations in children of <14 years...
  93. ncbi Cystatin C as a filtration marker--haemodialysis patients expose its strengths and limitations
    Per A Sjöström
    Department of Medicine, Orebro University Hospital, Orebro, Sweden
    Scand J Clin Lab Invest 69:65-72. 2009
    ..Haemodialysis patients with no residual renal function would be the best population in which to investigate these variables, which otherwise require reliable GFR measurements...
  94. ncbi Post liver transplantation acute kidney injury in a rat model of syngeneic orthotopic liver transplantation
    Jun Wang
    Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    Lab Invest 91:1158-69. 2011
    ..Our results demonstrate that protection of the liver graft and inhibition of the systemic inflammatory response are vital in reducing the risk of post-LT AKI...
  95. ncbi Use of the galactose-based contrast agent SHU 508A (Levovist) in renal ultrasonography of the dog
    M Pietra
    Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Alma Mater Studiorum University of Bologna, Via Tolara di Sopra, 50, 40064, Ozzano dell Emilia, BO, Italy
    Vet Res Commun 29:305-7. 2005
  96. ncbi Is it necessary to stent renal artery stenosis patients before cardiopulmonary bypass procedures?
    Bin Zheng
    Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
    Chin Med J (Engl) 124:1453-7. 2011
    ..The aim of this retrospective study was to investigate whether stent implantation before cardiopulmonary bypass has beneficial effect on development of AKI in renal artery stenosis (RAS) patients...
  97. ncbi Biomarkers of congenital obstructive nephropathy: past, present and future
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, USA
    J Urol 172:852-7. 2004
    ..This review addresses the need to define biomarkers that serve as surrogate end points for measuring the severity of obstruction, the evolution of renal maldevelopment and injury, and the response to medical or surgical intervention...
  98. ncbi How to assess renal function in the geriatric population
    Filippo Aucella
    IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Foggia, Italy
    J Nephrol 23:S46-54. 2010
  99. ncbi Enzyme replacement therapy in Fabry disease: a randomized controlled trial
    R Schiffmann
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, Bldg 10, Room 3D03, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1260, USA
    JAMA 285:2743-9. 2001
    ..Most patients experience debilitating neuropathic pain and premature mortality because of renal failure, cardiovascular disease, or cerebrovascular disease...
  100. ncbi Renal resistance index is a marker of future renal dysfunction in patients with essential hypertension
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon City, Ehime Japan
    J Nephrol 23:175-80. 2010
    ..Cystatin C is has been reported to be related to TOD in EHT. The aim of the present study was to clarify whether the RI predicts future renal function assessed by cystatin C levels in EHT...
  101. ncbi Influence of thyroid function on different kidney function tests
    Martin Kimmel
    Division of General Internal Medicine and Nephrology, Department of Internal Medicine, Robert Bosch Hospital, Stuttgart, Germany
    Kidney Blood Press Res 35:9-17. 2012
    The commonly used kidney function tests have limitations, especially in thyroid dysfunction. Therefore, we studied the most commonly used kidney function tests in patients with hypo- and hyperthyroidism and after reaching euthyroidism.

Research Grants70

  1. Microbubbles: a novel treatment for hemorrhagic shock
    CLAS LUNDGREN; Fiscal Year: 2007
    ..Indicators of health during long-term survival include liver and kidney function tests. The project is expected to bring the DDFPe treatment to a state of scientific underpinning and ..
  2. Mineral Metabolism and Cardiovascular Risk among Older Adults
    Bryan Kestenbaum; Fiscal Year: 2009
    ..Proposed analyses aim to clarify the roles of individual mineral markers with respect to CV health among older adults and to pave the way for future trials that target these markers as a means to improve CV outcomes. ..
  3. Cardiac Outcomes Associated with Renal Osteodystrophy
    Bryan Kestenbaum; Fiscal Year: 2007
    ..The proposed study aims to shed light on the relationship between a common renal related metabolic disorder and the epidemic burden of CVD found among this patient population. ..
  4. Defining the Clinical Significance of HbA1c Prior to the Onset of Diabetes
    Elizabeth Selvin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
    Allon Friedman; Fiscal Year: 2009
    ..abstract_text> ..
  6. Chronic Kidney Disease with Benign Prostatic Hyperplasia
    ANDREW RULE; Fiscal Year: 2004
    ..Based on preliminary data, a significant association between BPH surrogate measures and CKD is expected. This study will clarify whether earlier assessment and intervention in BPH is warranted to prevent CKD. ..
  7. Novel noninvasive assessment of cytochrome P450 activity
    Evan Kharasch; Fiscal Year: 2009
    ..This approach may identify inter-individual variability in drug disposition and response;permit more individualized dosing, and reduces the cost of drug interaction studies. ..
  8. The long-term consequences of postoperative acute kidney injury
    Areef Ishani; Fiscal Year: 2008
    ..Once the AKI- associated burden of CKD has been precisely estimated and modifiable factors have been identified, clinical trials can be performed that may reduce this disease burden. [unreadable] [unreadable] [unreadable]..
  9. HSP27 in Kidney Epithelial to Mesenchymal Transformation
    Arjang Djamali; Fiscal Year: 2008
    ..Overexpression of HSP27 will be obtained by recombinant virus-mediated HSP27 gene transfer. This proposal would allow us to determine whether HSP27 overexpression can prevent/delay EMT. ..
    Evan Kharasch; Fiscal Year: 2002
    ..More broadly, resulting biochemical and clinical insights will be applicable to the numerous other nephrotoxic haloalkenes that are ubiquitous environmental contaminants. ..
  11. Environmental & Genetic Risk Factors for Renal Function
    Virginia Weaver; Fiscal Year: 2009
    ..We believe the proposed work will allow a more complete understanding of the causes of renal function decline and lead to the development of public health interventions to prevent this considerable public health problem. ..
    GARY RANKIN; Fiscal Year: 2001
    ..Collectively, the results of these studies should add important, new knowledge about the nephrotoxic and urotoxic species of succinimides, cellular targets of the toxicant species and potential mechanisms of nephrotoxicity. ..
  13. Clinical Trial of Dietary Protein on Blood Pressure
    Jiang He; Fiscal Year: 2006
    ..Results from the proposed study may provide the scientific evidence for protein supplementation recommendations for the prevention and treatment of hypertension in the general population. ..
  14. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  15. Repopulation of Liver Allografts by Recipients
    Zhaoli Sun; Fiscal Year: 2007
    ..Our studies may provide new insights into the mechanisms which promote tolerance and regeneration after liver transplantation and will provide the basis for the development of novel therapies. [unreadable] [unreadable] [unreadable]..
  16. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2008
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  17. ATP-Sensitive K Channels in Renal Proximal Tubule
    Alan Segal; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. Small Laboratory Animal Imaging: High Resolution Microcomputed Tomography System
    RAMIRO TORIBIO; Fiscal Year: 2006
    ..Salary and benefits for the Supervisor and Space and utilities for the instrument will be provided by Department of Veterinary Biosciences and the College of Veterinary Medicine. [unreadable] [unreadable]..
  19. Biliary Microlithiasis in Alcohol Induced Pancreatitis
    Arun Sanyal; Fiscal Year: 2007
    ..The long-term goal is to use data from this R21 proposal to develop a RO1 proposal about a large scale phase III clinical trial of UDCA for alcohol-induced pancreatitis. [unreadable] [unreadable] [unreadable]..
  20. Early Glomerular Changes in Diabetic African-Americans
    Antonio Guasch; Fiscal Year: 2004
    ..This may lead to therapies that could be started very early on in diabetic patients targeted at preventing the development of kidney complications. ..
  21. The Coronary Screening for Kidney Transplantation (COST) Study
    Bertram Kasiske; Fiscal Year: 2008
    ..The money spent on these procedures might be better directed to health care measures of proven efficacy. [unreadable] [unreadable] [unreadable]..
  22. Mapping genes for proteinuria in type II diabetes
    Andrzej S Krolewski; Fiscal Year: 2010
    ..Furthermore while the proposed study aims to limit genetic and phenotypic heterogeneity to increase effectiveness, the generalizability of the findings will be verified by examining multi-center collections such as GoKinD and FIND. ..
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation of cHKA will significantly enhance our knowledge on a variety of pathologic conditions associated with electrolyte and acid-base abnormalities. ..
    JEFFREY SEGAR; Fiscal Year: 2001
  25. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  26. Improving Outcomes in Diabetic Nephropathy
    Robert Toto; Fiscal Year: 2008
    ..PERFORMANCE SITE ========================================Section End=========================================== ..
    Kenneth I Ataga; Fiscal Year: 2010
    ..abstract_text> ..
  28. 11th International Symposium on Urolithiasis
    ROSS HOLMES; Fiscal Year: 2008
    ..Particular emphasis will be placed on using the financial support to assist new, young, female and minority researchers to attend the meeting. [unreadable] [unreadable] [unreadable]..
  29. Fetal Cardiac Hypertrophy: Vascular/Metabolic Adaptation
    JEFFREY SEGAR; Fiscal Year: 2004
    ..The end result is hoped to be that the infant with a more 'normal' heart and circulatory physiology will have improved survival with less morbidity. ..
    Simona Baicu; Fiscal Year: 2003
    ..In the long-term, it is anticipated that cryopreservation by vitrification may permit the storage of tissue-engineered left ventricular assist devices or hearts. ..
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  32. Technology and Endothelial Biology of Kidney Injury Molecule-1
    Vishal Vaidya; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  33. 7th International Workshop on Primary Hyperoxaluria
    Dawn Milliner; Fiscal Year: 2005
    ..Recent crystallization of the AGT protein, and advances in the molecular genetics, diagnostic testing, and pharmacogenomics of PH make 2004 an exciting year for the 7th Workshop. ..
  34. Quantifying Left Ventricular Ejection Effectiveness
    Michael Pinsky; Fiscal Year: 2007
    ..The ultimate goal of this proposal is to develop and validate an echocardiographic-based algorithm that quantifies LV ejection effectiveness by merging both power and synchrony of contraction into a common metric. ..
  35. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2008
    ..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..
  36. Hepcidin and the pathogenesis of anemia in older adults.
    Richard D Semba; Fiscal Year: 2010
    ..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
  37. Calcitriol for Chemoprevention in Preinvasive Bronchial Epithelial Lesions
    Mary Reid; Fiscal Year: 2008
    ..abstract_text> ..
  38. Predictors of Nephropathy in Type 2 Diabetes
    Julie Lin; Fiscal Year: 2008
    ..D., Ph.D., a leading investigator in the field of nutritional epidemiology. This project proposal will provide the foundation for the candidate's future career as an independent and successful clinical scientist in renal research. ..
    Richard Semba; Fiscal Year: 2001
    ..The relationship between mastitis and breastmilk HIV load and the epidemiology and microbiology of mastitis will be examined in a new cohort of HIV-infected lactating women. ..
    Thomas Dowling; Fiscal Year: 2005
    ..abstract_text> ..
    Adele Viguera; Fiscal Year: 2003
    ..abstract_text> ..
    Chris Baylis; Fiscal Year: 2003
    ..Finally, she will evaluate the validity of the use of plasma and urinary NOX and will use Electron Spin Resonance (ESR) spectroscopy as an alternative method of determining NO production in vivo. ..
  43. Impact of Pancreas-Kidney Transplants on Renal Allograft
    Ajay Israni; Fiscal Year: 2002
    ..Renal allograft survival in SPK and KA will be compared using Cox proportional hazards models, adjusting for patient and transplant center characteristics. ..
    Natarajan Ranganathan; Fiscal Year: 2002
    ..It is equally feasible that our oral formulation may also have applications as a adjunct therapy for dialysis. ..
    Manoocher Soleimani; Fiscal Year: 2001
    ..Insight into regulation and gene structure of Na-coupled HCO3 transporters should enhance our knowledge on cell regulation and acid-base homeostasis. ..
    Karl Tryggvason; Fiscal Year: 2001
  47. Fetal Programming of Coronary Artery Disease
    JEFFREY SEGAR; Fiscal Year: 2005
    ..Only when the causes and mechanisms of hypertension and cardiovascular disease are understood in the context of a developmental process will it be possible to develop strategies for primary prevention. ..
  48. Regulation of GnRH Neuronal Development by FGF Signaling
    John Gill; Fiscal Year: 2005
    ..Critical stages of GnRH neuron development will be evaluated in mice to discern the functional contribution of FGF signaling in this important neuroendocrine system. ..
  49. Matrix metalloproteinases and diabetic nephropathy
    KATHRYN THRAILKILL; Fiscal Year: 2005
    ..We anticipate that this study will provide preliminary evidence to establish a link between dysregulation of MMP activity and the pathogenesis of nephropathy in type 1 DM. ..
  50. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..S. and elsewhere. ..
  51. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  52. Apical CI/OH-/HCO3-exchanger in kidney and GI tract
    Manoocher Soleimani; Fiscal Year: 2007
    ..They should further facilitate future investigations into the role of this transporter in pathophysiologic states affecting electrolyte and acid-base homeostasis. ..
    ANDRZEJ KROLEWSKI; Fiscal Year: 2001
    ANDRZEJ KROLEWSKI; Fiscal Year: 2004
    ..abstract_text> ..
    Kenneth Ataga; Fiscal Year: 2006
    ..e., is the "hypercoagulability" observed in patients with SCD a primary cause of the vasoocclusion or is it simply a secondary event that is observed in this clinical setting. ..
  56. The Urinary Proteome and Renal Function Loss in Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2008
    ..The proposed research on the mechanisms and determinants of early renal function decline is novel and will provide data for the development of effective methods of prevention of renal function loss in diabetes. [unreadable] [unreadable]..
  57. Mechanisms of Sexual Dimorphism in Perinatal Programming
    LORI WOODS; Fiscal Year: 2005
    ..Renal renin-angiotensin system components will be measured in the neonatal period, and arterial pressure, renal function, and glomerular number and volume will be measured in juvenile and adult animals. ..
  58. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  59. Mapping Genes for End-Stage Renal Disease in Type 1 Diabetes
    ANDRZEJ KROLEWSKI; Fiscal Year: 2008
    ..4) Investigate the ESRD-associated haplo-blocks to identify ESRD susceptibility genes through bioinformatics and molecular genetics protocols. [unreadable] [unreadable]..
  60. Biomarkers in the progression of nephropathy in type 2DM
    Julie Lin; Fiscal Year: 2008
    ..Data on how these modifiable biomarkers are related to kidney function decline could have an important and beneficial impact on treatment and monitoring of nephropathy in type 2 diabetes in the near future. [unreadable] [unreadable]..
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  62. Pathogenesis of wpk-induced Renal and Cerebral Disease
    Vincent Gattone; Fiscal Year: 2008
    ..abstract_text> ..
  63. Transgene Induced HIV-Associated Nephropathy
    Vincent Gattone; Fiscal Year: 2004
    ..By studying this HIV-transgenic rat, we should be able to identify additional factors that contribute to the HIV-induced phenotype in GECs and provide new information that will lead to a rational treatment for HIVAN. ..
    D Brater; Fiscal Year: 2004
    ..These data will provide insights into the causes and pathophysiology of decompensation in patients with CHF, thus enhancing our understanding of this increasingly prevalent disease and leading to better therapeutic strategies. ..
  65. High Pressure Freezing and Processing Unit
    Vincent Gattone; Fiscal Year: 2005
    ..The research and physical environment, EM Center personnel and IU School of Medicine institutional support make the IU EM Center an excellent place for the appropriate use of the Leica HPF and Processor System. ..
  66. Pharmacogenetic Optimization of Anticoagulation Therapy
    Nita Limdi; Fiscal Year: 2007
    ..With the award of the K23 grant, structured training, guidance of mentors, environment and institutional support provided by the University, I will develop the skills necessary for a productive career in pharmacogenetics research. ..
  67. Renal and Hormonal Mechanisms of Perinatal Programming
    LORI WOODS; Fiscal Year: 2005
    ..Intrarenal RAS activity will be measured in fetal and newborn animals. Arterial pressure, renal function, and nephron number will be measured in chronically instrumented juvenile and adult offspring. ..