passive cutaneous anaphylaxis

Summary

Summary: An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.

Top Publications

  1. pmc Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production
    D Hata
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Exp Med 187:1235-47. 1998
  2. ncbi The ethyl acetate extract of Cordyceps militaris inhibits IgE-mediated allergic responses in mast cells and passive cutaneous anaphylaxis reaction in mice
    Joo Yeon Oh
    Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    J Ethnopharmacol 135:422-9. 2011
  3. ncbi Resveratrol inhibits IgE-mediated basophilic mast cell degranulation and passive cutaneous anaphylaxis in mice
    Seon Young Han
    Department of Food Science and Nutrition, Hallym University, Chuncheon, Korea
    J Nutr 143:632-9. 2013
  4. pmc Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 205:2207-20. 2008
  5. ncbi Participation of proteinase-activated receptor-2 in passive cutaneous anaphylaxis-induced scratching behavior and the inhibitory effect of tacrolimus
    Yu Zhu
    Department of Pharmacy, Changhai Hospital, The Second Military Medical University
    Biol Pharm Bull 32:1173-6. 2009
  6. ncbi Recombinant Dirofilaria immitis-derived antigen can suppress passive cutaneous anaphylaxis reactions
    Y Furuhashi
    Section of Environmental Parasitology, Department of International Health Development, Division of Public Health, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int Arch Allergy Immunol 125:144-51. 2001
  7. ncbi Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice
    T Takai
    Department of Biotechnology, Faculty of Engineering, Okayama University, Japan
    Nature 379:346-9. 1996
  8. ncbi Mangiferin inhibits passive cutaneous anaphylaxis reaction and pruritus in mice
    Bomi Lee
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University Dongdaemun ku, Seoul, Korea
    Planta Med 75:1415-7. 2009
  9. ncbi An ELISA-based method for measurement of food-specific IgE antibody in mouse serum: an alternative to the passive cutaneous anaphylaxis assay
    Neil Birmingham
    Food Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USA
    J Immunol Methods 275:89-98. 2003
  10. ncbi Zinc is required for Fc epsilon RI-mediated mast cell activation
    Koki Kabu
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology RCAI, Yokohama, Kanagawa, Japan
    J Immunol 177:1296-305. 2006

Research Grants

  1. Targeting surface-bound IgE as a novel allergy therapeutic
    Ke Zhang; Fiscal Year: 2013
  2. IMMUNOREGULATION OF GUT EPITHELIUM TO ESCAPE PARASITISM
    GILBERT CASTRO; Fiscal Year: 1991
  3. IMMUNITY OF RATS AND GERBILS TO LITOMOSOIDES CARINII
    David Weiner; Fiscal Year: 1980
  4. ANTIGEN FRAGMENT SUPPRESSION OF THE IGE RESPONSE
    Arthur Malley; Fiscal Year: 1980
  5. Mechanisms of FcR-Mediated Inflammatory Responses
    Jean Pierre Kinet; Fiscal Year: 2009
  6. Calcium influx pathways in lymphocytes and mast cells
    Jean Pierre Kinet; Fiscal Year: 2008
  7. Role of the IgE-FceRI network in allergic inflammation
    Jean Pierre Kinet; Fiscal Year: 2005
  8. MOLECULAR ANALYSIS OF FCERI SIGNALING AND FUNCTION
    Jean Pierre Kinet; Fiscal Year: 2003
  9. Mechanism of IgE Mediated FceRI Regulation
    Jean Pierre Kinet; Fiscal Year: 2001
  10. CLINICAL AND FUNDAMENTAL IMMUNOLOGY
    Andrew Saxon; Fiscal Year: 2006

Detail Information

Publications239 found, 100 shown here

  1. pmc Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production
    D Hata
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Exp Med 187:1235-47. 1998
    ..Taken together, these results demonstrate an important role for Btk in the full expression of FcepsilonRI signal transduction in mast cells...
  2. ncbi The ethyl acetate extract of Cordyceps militaris inhibits IgE-mediated allergic responses in mast cells and passive cutaneous anaphylaxis reaction in mice
    Joo Yeon Oh
    Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    J Ethnopharmacol 135:422-9. 2011
    ..Cordyceps militaris has been used as a traditional herbal medicine for treating allergy in East Asia...
  3. ncbi Resveratrol inhibits IgE-mediated basophilic mast cell degranulation and passive cutaneous anaphylaxis in mice
    Seon Young Han
    Department of Food Science and Nutrition, Hallym University, Chuncheon, Korea
    J Nutr 143:632-9. 2013
    ..study investigated whether resveratrol suppressed immunoglobulin (Ig)E-mediated allergic responses and passive cutaneous anaphylaxis (PCA) in rat RBL-2H3 mast cells and in BALB/c mice...
  4. pmc Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 205:2207-20. 2008
    ..orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell-dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte infiltrates associated with such reactions in mice...
  5. ncbi Participation of proteinase-activated receptor-2 in passive cutaneous anaphylaxis-induced scratching behavior and the inhibitory effect of tacrolimus
    Yu Zhu
    Department of Pharmacy, Changhai Hospital, The Second Military Medical University
    Biol Pharm Bull 32:1173-6. 2009
    ..In the present study, we investigated the effects of several agents on passive cutaneous anaphylaxis-induced scratching behavior in ICR mice...
  6. ncbi Recombinant Dirofilaria immitis-derived antigen can suppress passive cutaneous anaphylaxis reactions
    Y Furuhashi
    Section of Environmental Parasitology, Department of International Health Development, Division of Public Health, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int Arch Allergy Immunol 125:144-51. 2001
    ..IgE levels were determined by ELISA. Homologous passive cutaneous anaphylaxis (PCA) reactions with anti-DNP-As IgE were examined 21 days after implantation...
  7. ncbi Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice
    T Takai
    Department of Biotechnology, Faculty of Engineering, Okayama University, Japan
    Nature 379:346-9. 1996
    ..Exploiting this property offers new therapeutic opportunities for the treatment of allergic and autoimmune disorders...
  8. ncbi Mangiferin inhibits passive cutaneous anaphylaxis reaction and pruritus in mice
    Bomi Lee
    Department of Life and Nanopharmaceutical Sciences, Kyung Hee University Dongdaemun ku, Seoul, Korea
    Planta Med 75:1415-7. 2009
    ..Orally and intraperitoneally administered mangiferin potently inhibited passive cutaneous anaphylaxis (PCA) reaction induced by IgE-antigen complex as well as pruritus induced by compound 48/80 in mice...
  9. ncbi An ELISA-based method for measurement of food-specific IgE antibody in mouse serum: an alternative to the passive cutaneous anaphylaxis assay
    Neil Birmingham
    Food Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48823, USA
    J Immunol Methods 275:89-98. 2003
    b>Passive cutaneous anaphylaxis (PCA) assay has been a gold standard method to measure allergen-specific IgE antibody (ASIgE Ab) levels in allergy mouse models...
  10. ncbi Zinc is required for Fc epsilon RI-mediated mast cell activation
    Koki Kabu
    Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology RCAI, Yokohama, Kanagawa, Japan
    J Immunol 177:1296-305. 2006
    ..These results revealed that Zn was involved in multiple steps of FcepsilonRI-induced MC activation and required for degranulation and cytokine production...
  11. ncbi Passive cutaneous anaphylaxis-inhibitory activity of flavanones from Citrus unshiu and Poncirus trifoliata
    Sung Hwan Park
    Department of Food and Nutrition, College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 71:24-7. 2005
    This study examined the passive cutaneous anaphylaxis-inhibitory activity of the flavanones isolated from the pericarp of Citrus unshiu (Family Rutaceae) and the fruit of Poncirus trifoliata (Family Rutaceae)...
  12. ncbi Tanshinones isolated from the rhizome of Salvia miltiorrhiza inhibit passive cutaneous anaphylaxis reaction in mice
    Hien Trung Trinh
    Department of Life and Pharmaceutical Sciences, Kyung Hee University, Dongdaemun ku, Seoul 130 701, Republic of Korea
    J Ethnopharmacol 132:344-8. 2010
    ..The rhizome of Salvia miltiorrhiza Bunge (SM, family Labiatae), which contains tanshinones as main constituents, has been used as a cardiovascular and anti-inflammatory agent in Chinese medicine...
  13. ncbi Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase
    Y Kanaoka
    Department of Medicine, Harvard Medical School and the Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 276:22608-13. 2001
    ..The zymosan-elicited intraperitoneal extravasation of plasma protein and the IgE-mediated passive cutaneous anaphylaxis in the ear were significantly diminished in the LTC(4)S (-/-) mice...
  14. pmc SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells
    V I Pivniouk
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 103:1737-43. 1999
    ..These results suggest that SLP-76 plays an important role in FcepsilonRI-mediated signaling in mast cells...
  15. ncbi Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors
    Sang Jun Han
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, 1 Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 30:2201-3. 2007
    ..Magnolol and honokiol potently inhibited passive cutaneous anaphylaxis reactions in mice induced by IgE-antigen complex as well as compound 48/80-induced scratching ..
  16. ncbi Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models
    Eun Ah Bae
    Department of Food and Nutrition, Kyung Hee University, Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 29:1862-7. 2006
    ..family Araliaceae) saponin fraction (KRGS) and its constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis (PCA) and contact dermatitis models were measured...
  17. pmc Homologous passive cutaneous anaphylaxis (PCA) in mice and heterologous PCA induced in rats with mouse IgE
    F Braga
    Immunology 30:655-69. 1976
    ..This fact seems to indicate that the physiological mechanism operating in mouse mast cells are different from those operating in rat mast cells...
  18. ncbi Expression and function of fibronectin binding integrins on rat mast cells
    M Yasuda
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Int Immunol 7:251-8. 1995
    ..In vivo, passive cutaneous anaphylaxis induced by IgE anti-DNP and DNP-BSA was inhibited by concurrent s.c...
  19. ncbi Induction of shrimp tropomyosin-specific hypersensitivity in mice
    Patrick S C Leung
    Division of Rheumatology Allergy and Clinical Immunology, School of Medicine, University of California, Davis, Calif, USA
    Int Arch Allergy Immunol 147:305-14. 2008
    ..The major shellfish allergen was identified as tropomyosin. Here, we investigated the immediate hypersensitivity responses, IgE and cell-mediated immune response in mice sensitized with recombinant shrimp tropomyosin...
  20. ncbi Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment:mouse models for the development of remedies for human allergic dermatitis
    Naoki Inagaki
    Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Japan
    J Pharmacol Sci 110:251-9. 2009
    ..One of the simplest allergic cutaneous reaction models is passive cutaneous anaphylaxis. Skin mast cells passively sensitized with antigen-specific IgE are activated upon antigen challenge ..
  21. ncbi Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R
    Renren Wen
    The Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 169:6743-52. 2002
    ..Moreover, PLCgamma2 plays a nonredundant role in Fc(gamma)R-mediated inflammatory skin reaction...
  22. ncbi Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene
    D Dombrowicz
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852
    Cell 75:969-76. 1993
    ..Therefore, interfering with its function should be an effective means of treating allergy, regardless of the allergen specificity...
  23. ncbi Hinokiresinol inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction
    Eun Ah Bae
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Planta Med 72:1328-30. 2006
    ..Orally and intraperitoneally administered hinokiresinol potently inhibited the passive anaphylaxis reaction in mice induced by IgE...
  24. ncbi Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells
    Ravi Malaviya
    Department of Allergy, Parker Hughes Institute, 2699 Patton Road, St Paul, MN 55113, USA
    J Immunol 168:421-6. 2002
    ..These findings provide unprecedented evidence that STAT6 plays a pivotal role in mast cell responses to IgE/Ag stimulation...
  25. ncbi Genetic selection for resistance or susceptibility to oral tolerance imparts correlation to both Immunoglobulin E level and mast cell number phenotypes with a profound impact on the atopic potential of the individual
    M F S da Silva
    Departamento de Imunologia, Universidade Federal do Rio de Janeiro, RJ, Brazil
    Clin Exp Allergy 36:1399-407. 2006
    ....
  26. ncbi Effect of Sinpo-Tang on the mast cell-mediated anaphylactic reactions
    Hyun Ja Jeong
    College of Pharmacy, Wonkwang University, KI Co Ltd, Iksan, Jeonbuk 570 749, South Korea
    Pharmacol Res 46:453-8. 2002
    ..SPT (0.001-0.1g/kg) significantly inhibited passive cutaneous anaphylaxis (PCA). The mast cell number was markedly decreased at the SPT-treated PCA site...
  27. ncbi In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:197-9. 2007
    ..main constituents, evodiamine and rutaecarpine, and evaluated in vivo their inhibitory effects against passive cutaneous anaphylaxis (PCA) reaction induced by IgE-antigen complex and scratching behaviors by compound 48/80...
  28. ncbi Ixeris dentata green sap inhibits both compound 48/80-induced aanaphylaxis-like response and IgE-mediated anaphylactic response in murine model
    Jin Mu Yi
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea
    Biol Pharm Bull 25:5-9. 2002
    ..05 and 0.1 g/kg. IXD (0.1 g/kg) also inhibited passive cutaneous anaphylaxis mediated by anti-dinitrophenyl IgE by 81.45%...
  29. ncbi In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components
    Yong Wook Shin
    College of Pharmacy, Kyung Hee University, Dongdaemun ku, Seoul, Korea
    Planta Med 73:257-61. 2007
    ..This suggests that the antiallergic effects of licorice are mainly due to glycyrrhizin, 18beta-glycyrrhetinic acid, and liquiritigenin, which can relieve IgE-induced allergic diseases such as dermatitis and asthma...
  30. ncbi Inhibition of immediate-type allergic reactions by the aqueous extract of Salvia plebeia
    Tae Yong Shi
    College of Pharmacy, Woosuk University, Chonju, Chonbuk, South Korea
    Immunopharmacol Immunotoxicol 24:303-14. 2002
    ..SPAE (0.001 and 1 g/kg) dose-dependently inhibited passive cutaneous anaphylaxis (PCA) when intraperitoneally, intraveneously or orally administered...
  31. ncbi Antiallergic/antiasthmatic effect of novel antiallergic hexapeptide-95/220 in various experimental models
    R Singh
    Division of Pharmacology, Central Drug Research Institute, Lucknow, India
    Indian J Exp Biol 39:871-7. 2001
    ..Hexapeptide 95/220 inhibited immediate hypersensitivity reactions such as passive cutaneous anaphylaxis (PCA) and mast cell degranulation in rats, antigen-induced bronchoconstriction in actively sensitized ..
  32. ncbi Absence of platelet endothelial cell adhesion molecule-1 (CD31) leads to increased severity of local and systemic IgE-mediated anaphylaxis and modulation of mast cell activation
    Mae Xhum Wong
    Division of Hematology, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    J Immunol 168:6455-62. 2002
    ..These results suggest that PECAM-1 acts as a counterregulator in allergic disease susceptibility and severity and negatively modulates mast cell activation...
  33. ncbi Rat monoclonal anti-murine IgE antibody removes IgE molecules already bound to mast cells or basophilic leukemia cells, resulting in the inhibition of systemic anaphylaxis and passive cutaneous anaphylaxis
    Hiroaki Miyajima
    Division of Pathobiology, Juntendo University School of Medicine, Jikei University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 128:24-32. 2002
    ..No passive cutaneous anaphylaxis occurred if the rats were injected with anti-IgE antibodies before the challenge...
  34. ncbi Anti-anaphylactic effect of Euphorbia hirta
    M S Youssouf
    Division of Pharmacology and Natural Product Chemistry, Indian Institute of Integrative Medicine, Jammu Tawi, India
    Fitoterapia 78:535-9. 2007
    ..At the same range of dose, EH-A001 inhibited passive cutaneous anaphylaxis (PCA) in rat and active paw anaphylaxis in mice...
  35. ncbi Gamijeonssibaekchulsan regulates mast cell-mediated anaphylactic reaction
    Phil Dong Moon
    College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea
    Acta Biochim Pol 54:349-55. 2007
    ..We also assayed histamine release and passive cutaneous anaphylaxis (PCA) in mice and cytokine productions in MOLT-4 cells...
  36. ncbi Inhibitory effect of mast cell-mediated acute and chronic allergic reactions by Dodutang
    Hye Young Shin
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, 570 749, South Korea
    Immunopharmacol Immunotoxicol 24:583-94. 2002
    ..Dodutang (0.001-5 g/kg) dose-dependantly inhibited the passive cutaneous anaphylaxis reaction activated by anti-dinitrophenyl (DNP) IgE in a rat model, especially, by 78...
  37. ncbi Anti-allergic action of buckwheat (Fagopyrum esculentum Moench) grain extract
    Chang Deok Kim
    Oriental Hospital, Oriental Medical College of Daejeon University, 22 5 Daeheung dong, Daejeon 301 724, South Korea
    Int Immunopharmacol 3:129-36. 2003
    ..In addition, BGE showed potent inhibitory effect on passive cutaneous anaphylaxis (PCA) activated by anti-dinitrophenyl (DNP) IgE when orally administered...
  38. ncbi Rubus croceacanthus Leveille inhibits mast cell-mediated anaphylactic-like reaction and tumor necrosis factor-alpha secretion
    Phil Dong Moon
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk, 570 749, South Korea
    Biol Pharm Bull 27:1359-63. 2004
    ..RCL also inhibited passive cutaneous anaphylaxis activated by anti-DNP IgE...
  39. ncbi IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13
    Susan C Fish
    Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 174:7716-24. 2005
    ..These findings suggest that a mechanism for IgE production exists in vivo that is independent of IL-4 or IL-13...
  40. ncbi Antiallergic activity of hesperidin is activated by intestinal microflora
    Neung Kee Lee
    School of Oriental Medicine, Kyung Hee University, Seoul, Korea
    Pharmacology 71:174-80. 2004
    ..7 cells. Hesperetin weakly inhibits cyclooxygenase 2 enzyme activities. These results suggest that hesperidin may be a prodrug, which is metabolized to hesperetin by intestinal bacteria...
  41. ncbi Inhibition of mast cell-dependent allergy reaction by extract of black cohosh (Cimicifuga racemosa)
    Chang Deok Kim
    Oriental Hospital, Oriental Medical College of Daejeon University, Daejeon, South Korea
    Immunopharmacol Immunotoxicol 26:299-308. 2004
    ..The oral administration of BCE significantly inhibited the anti-IgE-induced passive cutaneous anaphylaxis (PCA) reaction...
  42. ncbi Inhibitory effect of Yunbutang on mast cell-dependent allergic reactions
    Ho Jeong Na
    Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea
    Immunopharmacol Immunotoxicol 26:233-42. 2004
    ..YB also showed an inhibitory effect of anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction by oral administration...
  43. ncbi Inhibition of immediate allergic reactions by ethanol extract from Plumbago zeylanica stems
    Yue Dai
    Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China
    Biol Pharm Bull 27:429-32. 2004
    ..inhibited systemic anaphylactic shock induced by compound 48/80 in mice, reduced homologous passive cutaneous anaphylaxis and skin reactions induced by histamine or serotonin in rats, significant differences were observed at ..
  44. ncbi Sopoongsan inhibits mast cell-mediated anaphylactic reactions and inflammatory cytokine secretion
    Ho Jeong Na
    College of Pharmacy, Woosuk University, Jeonbuk, South Korea
    Int Arch Allergy Immunol 139:31-7. 2006
    ..The precise effect in experimental models of SPS, however, remains unknown. In this report, we investigated the effect of SPS on mast cell-mediated anaphylactic reactions and cytokine production in in vivo and in vitro murine models...
  45. ncbi The anti-anaphylactic effect of the gall of Rhus javanica is mediated through inhibition of histamine release and inflammatory cytokine secretion
    Sang Hyun Kim
    Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 700 422, South Korea
    Int Immunopharmacol 5:1820-9. 2005
    ..Our findings provide evidence that GRJ inhibits mast cell-derived immediate-type allergic reactions, and suggest the possible mechanisms of action...
  46. ncbi Inhibitory effects of Xanthii fructus extract on mast cell-mediated allergic reaction in murine model
    Seung Heon Hong
    Department of Oriental Pharmacy, College of Pharmacy, VCRC of Wonkwang University, Iksan, Jeonbuk 570 749, South Korea
    J Ethnopharmacol 88:229-34. 2003
    ..Our studies provide evidence that XF may be beneficial in the treatment of various types allergic diseases...
  47. ncbi Antiallergic principles from Alpinia galanga: structural requirements of phenylpropanoids for inhibition of degranulation and release of TNF-alpha and IL-4 in RBL-2H3 cells
    Hisashi Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 13:3197-202. 2003
    ..In addition, 1'S-1'-acetoxychavicol acetate and 1'S-1'-acetoxyeugenol acetate inhibited ear passive cutaneous anaphylaxis reactions in mice and the antigen-IgE-mediated TNF-alpha and IL-4 production, both of which ..
  48. ncbi Action of Dracocephalum argunense on mast cell-mediated allergy model
    Sang Hyun Kim
    Department of Pharmacology, Kyungpook National University Medical School, Daegu, South Korea
    Biol Pharm Bull 29:494-8. 2006
    ..Our findings provide evidence that DAAE inhibits mast cell derived allergic reactions, and involvement of cAMP for histamine release and p38 MAPK for pro-inflammatory cytokine secretion in these effects...
  49. ncbi Mosla dianthera inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production
    Dong Hee Lee
    College of Pharmacy, Woosuk University, Jeonju 565 701, Republic of Korea
    Toxicol Appl Pharmacol 216:479-84. 2006
    ..AEMD decreased immunoglobulin E-mediated local allergic reactions, passive cutaneous anaphylaxis. AEMD attenuated intracellular calcium level and release of histamine from rat peritoneal mast cells ..
  50. ncbi Antiallergic activity of a disaccharide isolated from Sanguisorba officinalis
    Kwan Ha Park
    Department of Marine Biomedical Sciences, Kunsan National University, Chonbuk, Hwayang Dong 1, Kwangjin ku, Seoul, Korea 143 701
    Phytother Res 18:658-62. 2004
    ..Intravenously administered compound inhibited the passive cutaneous anaphylaxis response in rats in a dose-dependent manner (ED(50) = 9.6 mg/kg)...
  51. ncbi Effect of disodium cromoglycate on mast cell-mediated immediate-type allergic reactions
    Hye Young Shin
    College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Iksan, Jeonbuk 570 749, South Korea
    Life Sci 74:2877-87. 2004
    ..DSCG inhibited systemic allergic reaction induced by compound 48/80 dose-dependently. Passive cutaneous anaphylaxis was inhibited by 71.6% by oral administration of DSCG (1 g/kg)...
  52. ncbi Lactic acid bacteria increase antiallergic effect of Artemisia princeps pampanini SS-1
    Seung Hoon Lee
    College of Pharmacy, Kyung Hee University, Dongdaemun ku, Seoul 130 701, Korea
    Arch Pharm Res 29:752-6. 2006
    ..which is called Ssajuarissuk in Korean (SS-1), was fermented with lactic acid bacteria (LAB) and their passive cutaneous anaphylaxis reaction-inhibitory activity was investigated...
  53. ncbi Inhibitory effects of Selaginella tamariscina on immediate allergic reactions
    Yue Dai
    Department of Pharmacology, China Pharmaceutical University, China
    Am J Chin Med 33:957-66. 2005
    ..It can also dose-dependently block rat homologous passive cutaneous anaphylaxis and skin reactions caused by exogenous histamine and serotonin with a significant difference observed ..
  54. ncbi Inhibitory effects of Okbyungpoong-Gamhmi on anaphylactic responses
    Seung Heon Hong
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570 749, Republic of Korea
    J Ethnopharmacol 98:361-5. 2005
    ..01-1g/kg. OG also inhibited the passive cutaneous anaphylaxis at the same concentrations...
  55. ncbi Observations of Forsythia koreana methanol extract on mast cell-mediated allergic reactions in experimental models
    In Young Choi
    Department of Pharmacology, College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University, 1 Hoegi dong, Dongdaemun Gu, Seoul 130 701, South Korea
    In Vitro Cell Dev Biol Anim 43:215-21. 2007
    ..systemic anaphylaxis, ear swelling, and anti-dinitrophenyl (DNP) immunoglobulin E (IgE)-induced passive cutaneous anaphylaxis (PCA)...
  56. ncbi Inhibition of immediate-type allergic reactions by Prunella vulgaris in a murine model
    T Y Shin
    College of Pharmacy, Woosuk University, Chonju, Chonbuk, South Korea
    Immunopharmacol Immunotoxicol 23:423-35. 2001
    ..PVAE (0.001 to 1 g/kg) inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently...
  57. ncbi Camellia japonica suppresses immunoglobulin E-mediated allergic response by the inhibition of Syk kinase activation in mast cells
    J H Lee
    Department of Immunology and Physiology, College of Medicine, Konkuk University, Chungju, Korea
    Clin Exp Allergy 38:794-804. 2008
    ..Novel approaches are being explored to develop new therapies for various allergic diseases. Complementary and alternative medicines are considered to be promising avenues for the development of such new therapies...
  58. ncbi Inhibitory effect of anaphylactic reaction of Sosiho-Tang
    H M Kim
    College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea
    Immunopharmacol Immunotoxicol 20:567-78. 1998
    ..These results indicate that SS-Tang may contain compounds with actions that inhibit mast cell degranulation...
  59. ncbi Procyanidin C1 from apple extracts inhibits Fc epsilon RI-mediated mast cell activation
    Nobuhiro Nakano
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 147:213-21. 2008
    ....
  60. ncbi Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro
    Yasuko Ishikawa
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    J Med Food 11:14-20. 2008
    ..The in vivo effect of orally administered BP on cutaneous mast cell activation was examined by passive cutaneous anaphylaxis reaction...
  61. ncbi Inhibitory effect of schizandrin on passive cutaneous anaphylaxis reaction and scratching behaviors in mice
    Bomi Lee
    College of Pharmacy, Kyung Hee University, Seoul, Korea
    Biol Pharm Bull 30:1153-6. 2007
    ..effect of the fruit of Schizandra chinensis Baill (Family Magnoliaceae), which inhibited the mouse passive cutaneous anaphylaxis (PCA) reaction in a preliminary experiment, its main constituent, schizandrin, was isolated and its ..
  62. ncbi Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats
    T Y Shin
    College of Pharmacy, Woosuk University, Wanju, Chonbuk, South Korea
    Immunopharmacol Immunotoxicol 21:705-15. 1999
    ..These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-alpha production from RPMC...
  63. ncbi Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk
    Jun Ho Lee
    Department of Immunology and Physiology, College of Medicine, Konkuk University, Chungju, Korea
    J Allergy Clin Immunol 121:1225-31. 2008
    ..Curcumin can block this activation, but the mechanism and the effects of curcumin on IgE-mediated allergic reactions are unknown...
  64. ncbi Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by Perilla frutescens
    T Y Shin
    College of Pharmacy, Woosuk University, Chonju, Chonbuk, South Korea
    Immunopharmacol Immunotoxicol 22:489-500. 2000
    ..001 and 0.01 mg/ml) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha production. These results indicate that PFAE inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro...
  65. ncbi Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis
    T Y Shin
    College of Pharmacy, Woosuk University, Chonju, 565-701, Chonbuk, South Korea
    J Ethnopharmacol 74:133-40. 2001
    ..b>Passive cutaneous anaphylaxis was inhibited by 63.5+/-7.8% by oral administration of WFTC (1.0 g/kg)...
  66. ncbi Antiallergic effects of Vitis amurensis on mast cell-mediated allergy model
    Sang Hyun Kim
    Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700 422, South Korea
    Exp Biol Med (Maywood) 233:192-9. 2008
    ..MEVA decreased immunoglobulin E (IgE)-mediated local allergic reactions, passive cutaneous anaphylaxis. MEVA dose-dependently reduced histamine release from mast cells activated by compound 48/80 or IgE...
  67. ncbi Effect of allergina on mast cell-mediated allergic reactions
    H J Jeong
    Department of Oriental Pharmacy, College of Pharmacy, and Korea Institute of Oriental Pharmacy, Iksan, Chonbuk
    Immunopharmacol Immunotoxicol 23:627-37. 2001
    ..ALLERGINA (1 g/kg) also inhibited passive cutaneous anaphylaxis by 84%. ALLERGINA dose-dependently inhibited histamine release from rat peritoneal mast cells...
  68. pmc Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains
    D Dombrowicz
    Molecular Allergy and Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Clin Invest 99:915-25. 1997
    ....
  69. ncbi Mast cell-mediated allergic response is suppressed by Sophorae flos: inhibition of SRC-family kinase
    Jun Ho Lee
    Department of Immunology, College of Medicine, Konkuk University, Chungyu Korea
    Exp Biol Med (Maywood) 233:1271-9. 2008
    ..flos also suppressed the expression and secretion of TNF-alpha and IL-4 in the cells and IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. Sophorae flos inhibited the activating phosphorylation of Syk and LAT in mast cells...
  70. ncbi P- and E-selectins are required for the leukocyte recruitment, but not the tissue swelling, associated with IgE- and mast cell-dependent inflammation in mouse skin
    F de Mora
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Lab Invest 78:497-505. 1998
    ....
  71. ncbi Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol
    Bomi Lee
    Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, 1 Hoegi, Dongdaemun ku, Seoul, Korea
    Arch Pharm Res 31:445-50. 2008
    ..These findings suggest that PL can improve IgE-induced anaphylaxis and scratching behaviors, and may be due to the effect of its constituents, paeoniflorin and paeonol...
  72. ncbi Characterization of dog allergens Can f 1 and Can f 2. 1. Preparation of their recombinant proteins and antibodies
    Yoichi Kamata
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka, Japan
    Int Arch Allergy Immunol 142:291-300. 2007
    ..Recombinant dog allergens, rCan f 1 and rCan f 2, and their antibodies are good tools for the characterization of dog allergens in order to develop modern therapeutic and preventive methods for dog allergy...
  73. ncbi Reductively aminated D-xylose-albumin conjugate as the immunogen for generation of IgG and IgE antibodies specific to D-xylitol, a haptenic allergen
    Kundimi Sreenath
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute CFTRI, Mysore 570020, Karnataka State, India
    Bioconjug Chem 18:1995-2003. 2007
    ..D-Xylitol-BSA conjugate was used to raise IgE antibodies in BALB/c mice by repeated intradermal administration. Passive cutaneous anaphylaxis using the immune sera confirmed the haptenic nature of xylitol.
  74. pmc Strain-dependency of leukotriene C4 generation from isolated lungs of immunized mice
    C Zuany Amorim
    , , INSERM No 285, Paris, France
    Br J Pharmacol 112:1230-6. 1994
    ..4. Swiss and CBA/J mice exhibited higher titers of circulating IgG antibodies, as measured by passive cutaneous anaphylaxis (PCA), than Balb/C mice...
  75. ncbi The role of thromboxane A2 (TxA2) in allergic cutaneous reactions and the effect of (E)-3-[p-(1H-imidazol-1-ylmethyl) phenyl]-2-propenoic acid hydrochloride (OKY-046), a TxA2 synthetase inhibitor
    H Nagai
    Department of Pharmacology, Gifu Pharmaceutical University, Japan
    Prostaglandins Leukot Essent Fatty Acids 35:125-30. 1989
    ..b>Passive cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibited by OKY-046 but not by indomethacin...
  76. ncbi Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis
    Yue Dai
    Department of Biology and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin
    Biol Pharm Bull 25:1179-82. 2002
    ..At doses of 500 and 1000 mg/kg, AFGS showed a clear inhibition on homologous passive cutaneous anaphylaxis in rats...
  77. ncbi Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear
    Junichi Kawagoe
    Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company Ltd, Higashimurayama, Japan
    Jpn J Pharmacol 88:77-84. 2002
    ..of picryl chloride (PC) or oxazolone (Ox) after sensitization, and vascular permeability after ear passive cutaneous anaphylaxis (PCA) were compared between wild-type (WT) and PAR-2(-/-) mice...
  78. ncbi Comparison of the efficacy of tacrolimus and cyclosporine A in a murine model of dinitrofluorobenzene-induced atopic dermatitis
    Hirotaka Yamashita
    Gifu Pharmaceutical University, Mitahorahigashi, Gifu 502 8585, Japan
    Eur J Pharmacol 645:171-6. 2010
    ..addition, both drugs attenuated increases in vascular permeability and scratching behavior induced by passive cutaneous anaphylaxis. These results indicate that inhibition of the CaN pathway plays an important role in tacrolimus- and ..
  79. ncbi Suppressive effect of strychnos nux-vomica on induction of ovalbumin-specific IgE antibody response in mice
    Govinda Rao Duddukuri
    Department of Biochemistry, GITAM University, Visakhapatnam 530 045, Andhra Pradesh, India
    Indian J Biochem Biophys 45:341-4. 2008
    ..on induction of ovalbumin (OVA)-specific IgE antibody response in a murine model, as evaluated by passive cutaneous anaphylaxis (PCA)...
  80. ncbi Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes
    Sang Hyun Kim
    Department of Pharmacology, Kyungpook National University Medical School, Daegu 700 422, Republic of Korea
    Food Chem Toxicol 45:2138-44. 2007
    ..AXE decreased immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction...
  81. ncbi Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells
    Eun Kyoung Kim
    Department of Anatomy, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea
    Biosci Biotechnol Biochem 71:2886-92. 2007
    ..LR orally administered at 6.59 mg/100 g also inhibited the anti-DNP IgE-induced passive cutaneous anaphylaxis reaction...
  82. ncbi Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant
    Keigo Nakatani
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Biol Pharm Bull 25:1137-41. 2002
    ..In addition, passive cutaneous anaphylaxis (PCA) reactions in rats were significantly inhibited by this ethanol extract as well as by the water ..
  83. ncbi Anti-allergic effects of fermented Ixeris sonchifolia and its constituent in mice
    Hien Trung Trinh
    Kyung Hee Universitym, Seoul, Korea
    J Microbiol Biotechnol 20:217-23. 2010
    ..IS Kimchi more potently inhibited the passive cutaneous anaphylaxis (PCA) reaction induced by an IgE-antigen complex as well as the scratching behavior induced by ..
  84. ncbi Infection with influenza a virus leads to flu antigen-induced cutaneous anaphylaxis in mice
    Susanne M Grunewald
    Klinik und Poliklinik für Haut und Geschlechtskrankheiten, Universitat Wurzburg, Wurzburg, Germany
    J Invest Dermatol 118:645-51. 2002
    ..Interestingly, flu-infected mice developed active and passive cutaneous anaphylaxis after rechallenge with flu-antigen...
  85. ncbi Suppression of type-I allergic responses by oral administration of grape marc fermented with Lactobacillus plantarum
    Takanari Tominaga
    Department of Biosciences, Graduate School of Science, Kitasato University, Sagamihara, Kanagawa, Japan
    Immunopharmacol Immunotoxicol 32:593-9. 2010
    ..For passive cutaneous anaphylaxis (PCA) reaction, BALB/c mice received intradermal sensitization with anti-OVA IgE serum and were ..
  86. ncbi [Study on the immunotoxicity of ribosome inhibiting protein of Momordica charantia]
    Li Wan
    Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:1033-7. 2009
    ..To separate and purify ribosome inhibiting protein (RIP) from Momordica charantia (bitter melon) seeds and to evaluate its acute toxicity and immunotoxicity in animal...
  87. ncbi Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients
    Hiroshi Shimoda
    Research and Development Division, Oryza Oil and Fat Chemical Company, Ltd, Ichinomiya, Aichi 493 8001, Japan
    J Agric Food Chem 54:2915-20. 2006
    ..In the passive cutaneous anaphylaxis reaction in rats, a single oral treatment of JBE (1000 mg/kg) was found to suppress the reaction...
  88. ncbi [Establishment of a rat chronic asthma model and its evaluation]
    Zhong Cheng Liu
    College of Pharmaceutical Science, Hebei University, Baoding 071002, China
    Yao Xue Xue Bao 45:718-23. 2010
    ..The optical density at 610 nm of extractive from locus caeruleus was detected by passive cutaneous anaphylaxis (PCA)...
  89. ncbi Anti-allergic effects of Lycopus lucidus on mast cell-mediated allergy model
    Tae Yong Shin
    College of Pharmacy, Woosuk University, Jeonju, Jeonbuk 565 701, South Korea
    Toxicol Appl Pharmacol 209:255-62. 2005
    ..LAE decreased the local allergic reaction, passive cutaneous anaphylaxis, activated by anti-dinitrophenyl (DNP) IgE antibody...
  90. ncbi Oral allergy syndrome and anaphylactic reactions in BALB/c mice caused by soybean glycinin and beta-conglycinin
    X Liu
    The Key Laboratory of Molecular Animal Nutrition, College of Animal Science, Zhejiang University, Ministry of Education, Hangzhou, China
    Clin Exp Allergy 38:350-6. 2008
    ..Many reports have indicated that glycinin and beta-conglycinin have been characterized as major soybean allergens involved in food hypersensitivity...
  91. ncbi A small amount of tetrachloroethylene ingestion from drinking water accelerates antigen-stimulated allergic responses
    Makoto Seo
    Laboratory of Hygienics, Gifu Pharmaceutical University, Gifu, Japan
    Immunobiology 213:663-9. 2008
    ..After exposure of Wistar rats to PCE in drinking water for 2 or 4 weeks, we performed a passive cutaneous anaphylaxis (PCA) reaction. PCE exposure for 4 weeks enhanced PCA reaction in a dose-dependent manner...
  92. ncbi Influence of plant lipids on immune responses in mice to the major Brazil nut allergen Ber e 1
    R J Dearman
    Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, UK
    Clin Exp Allergy 37:582-91. 2007
    ..Lipids, particularly bacterial lipopolysaccharide, can impact on immune responses to proteins, with low doses enhancing type 2 responses...
  93. ncbi Effects of Prunella vulgaris on mast cell-mediated allergic reaction and inflammatory cytokine production
    Sang Yong Kim
    Division of Specimen and Genetic Resources, Korea National Arboretum, Pocheon, Gyeonggi, South Korea
    Exp Biol Med (Maywood) 232:921-6. 2007
    ..PVAE decreased the IgE-mediated local allergic reaction, passive cutaneous anaphylaxis. In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-..
  94. ncbi Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis
    Ana Tereza Cerqueira-Lima
    Instituto de Ciências da Saúde, Universidade Federal da Bahia, Bahia, Brazil
    Curr Drug Targets 11:1458-67. 2010
    ..cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and IFN-γ levels in BAF; (f) histopathological alterations in the lung...
  95. ncbi Study of adjuvant effect of model surfactants from the groups of alkyl sulfates, alkylbenzene sulfonates, alcohol ethoxylates and soaps
    S K Clausen
    The National Institute of Occupational Health, Lersø Parkallé 105, DK 2100 Copenhagen, Denmark
    Food Chem Toxicol 38:1065-74. 2000
    ..1 microg sc) in saline. OVA-specific IgE antibodies were determined by the heterologous mouse rat passive cutaneous anaphylaxis test. The results were confirmed by a specific ELISA method...
  96. ncbi Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells
    Akiko Nagasaka
    Department of Dermatology, University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi, Japan
    Eur J Immunol 38:489-99. 2008
    ..Both effects were mediated by OPN receptors (i.e. CD44 and integrin alphav). IgE-mediated passive cutaneous anaphylaxis was significantly reduced in OPN(-/-) mice compared with OPN(+/+) mice, indicating physiological ..
  97. ncbi Stachys riederi inhibits mast cell-mediated acute and chronic allergic reactions
    Tae Yong Shin
    College of Pharmacy, Woosuk University, Jeonju, Jeonbuk, South Korea
    Immunopharmacol Immunotoxicol 26:621-30. 2004
    ..SRAE inhibited systemic allergic reaction induced by compound 48/80. SRAE dose-dependently inhibited passive cutaneous anaphylaxis (PCA) activated by anti-dinitrophenyl (DNP) IgE...
  98. ncbi A new series of antiallergic agents. I. Synthesis and activity of 11-(2-aminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin derivatives
    E Ohshima
    Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co, Ltd, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 39:2724-8. 1991
    ..oxepin-2-carboxylic acid hydrochloride, was the most potent in the rat passive cutaneous anaphylaxis test (ED50 = 0.92 mg/kg p.o.)...
  99. ncbi Biochemical, antigenic and allergenic characterization of crude extracts of Drechslera (Helminthosporium) monoceras
    E A Menezes
    Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
    Mycopathologia 131:75-81. 1995
    ..verify the induction of IgE antibody responses in immunizations of Balb/c and cAF-1 mice, and titer by passive cutaneous anaphylaxis test using Wistar rats. The maximum titers obtained were 160 in cAF-1 mice and 1.280 in Balb/c mice...
  100. ncbi Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases
    Andrew Saxon
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1680, USA
    Curr Opin Allergy Clin Immunol 4:563-8. 2004
    ....
  101. ncbi [CD11b-positive cells expression in rectal mucosa from ovalbumin sensitized and challenged rabbits]
    Norberto Bassan
    Cátedra de Histología, Citología y Embriología, Facultad de Medicina de Rosario, Universidad Abierta Interamericana, Rosario, Argentina
    Acta Gastroenterol Latinoam 35:7-12. 2005
    ..Sensitized groups (G2 and G3) showed a positive PCA (Passive Cutaneous Anaphylaxis) at 1/160 fold dilutions...

Research Grants13

  1. Targeting surface-bound IgE as a novel allergy therapeutic
    Ke Zhang; Fiscal Year: 2013
    ..We will use a systemic allergic anaphylaxis model, passive cutaneous anaphylaxis model and human basophil stimulation to test an E-3.56's safety and therapeutic efficacy...
  2. IMMUNOREGULATION OF GUT EPITHELIUM TO ESCAPE PARASITISM
    GILBERT CASTRO; Fiscal Year: 1991
    ..Host hypersensitivity will be gauged through passive cutaneous anaphylaxis and Schultz-Dale reactions and an in vivo "equivalent" of the Schultz-Dale reaction which involves ..
  3. IMMUNITY OF RATS AND GERBILS TO LITOMOSOIDES CARINII
    David Weiner; Fiscal Year: 1980
    ..Serum will be assessed for antibody using indirect hemagglutination and passive cutaneous anaphylaxis. Lymphoid cells will be assessed for sensitization by their responses to various mitogens and to ..
  4. ANTIGEN FRAGMENT SUPPRESSION OF THE IGE RESPONSE
    Arthur Malley; Fiscal Year: 1980
    ..Antibody responses will be measured by radioimmunoassay (IgG) and passive cutaneous anaphylaxis (IgE)...
  5. Mechanisms of FcR-Mediated Inflammatory Responses
    Jean Pierre Kinet; Fiscal Year: 2009
    ..Moreover, they will provide the proof of concept for the therapeutic use of these antibodies in the context of MC-associated diseases. ..
  6. Calcium influx pathways in lymphocytes and mast cells
    Jean Pierre Kinet; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  7. Role of the IgE-FceRI network in allergic inflammation
    Jean Pierre Kinet; Fiscal Year: 2005
    ..abstract_text> ..
  8. MOLECULAR ANALYSIS OF FCERI SIGNALING AND FUNCTION
    Jean Pierre Kinet; Fiscal Year: 2003
    ..He will investigate 1) whether there are differences between individuals in the betaWT/betaT ratio, and 2) whether these differences correlate with allergic status. ..
  9. Mechanism of IgE Mediated FceRI Regulation
    Jean Pierre Kinet; Fiscal Year: 2001
    ..Taken together, these analyses will provide significant insights into the process and molecular parameters that control the IgE-mediated regulation of FceRI expression. ..
  10. CLINICAL AND FUNDAMENTAL IMMUNOLOGY
    Andrew Saxon; Fiscal Year: 2006
    ..abstract_text> ..
  11. Allergy Therapy with Chimeric Human Ig Proteins
    Andrew Saxon; Fiscal Year: 2007
    ..Further, understanding of the mechanisms underlying the control of activating receptors by inhibitory receptors will have broad reaching implications for the manipulation the immune response. ..
  12. MAST CELLS IN INNATE IMMUNITY AGAINST BACTERIAL INFECTIO
    Ravi Malaviya; Fiscal Year: 2001
    ..These studies will provide new insights regarding the participation of mast cells in innate host defense against pathogenic gram negative bacteria. ..
  13. XENOBIOTICS AND ALLERGIC INFLAMMATION
    Andrew Saxon; Fiscal Year: 2005
    ..The projects are supported by a DEP collection and fractionation core, a mouse core, and a administrative, patient and sample coordination core. ..