routine diagnostic tests


Summary: Diagnostic procedures, such as laboratory tests and x-rays, routinely performed on all individuals or specified categories of individuals in a specified situation, e.g., patients being admitted to the hospital. These include routine tests administered to neonates.

Top Publications

  1. pmc Cost-effectiveness of malaria diagnostic methods in sub-Saharan Africa in an era of combination therapy
    Samuel Shillcutt
    Andean Health and Development Saludesa, Quito, Ecuador
    Bull World Health Organ 86:101-10. 2008
  2. ncbi Empirical evidence of design-related bias in studies of diagnostic tests
    J G Lijmer
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, The Netherlands
    JAMA 282:1061-6. 1999
  3. pmc Influence of rapid malaria diagnostic tests on treatment and health outcome in fever patients, Zanzibar: a crossover validation study
    Mwinyi I Msellem
    Malaria Control Programme, Ministry of Health and Social Welfare, Zanzibar, Tanzania
    PLoS Med 6:e1000070. 2009
  4. pmc Grading quality of evidence and strength of recommendations for diagnostic tests and strategies
    Holger J Schunemann
    Department of Epidemiology, Italian National Cancer Institute Regina Elena, 00144 Rome, Italy
    BMJ 336:1106-10. 2008
  5. pmc Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda
    Daniel J Kyabayinze
    Malaria Consortium Africa, Plot 2, Sturrock Road, P O Box 8045, Kampala, Uganda
    Malar J 7:221. 2008
  6. pmc Dispensary level pilot implementation of rapid diagnostic tests: an evaluation of RDT acceptance and usage by providers and patients--Tanzania, 2005
    Holly Ann Williams
    International Emergency and Refugee Health Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Malar J 7:239. 2008
  7. pmc Costs and consequences of the US Centers for Disease Control and Prevention's recommendations for opt-out HIV testing
    David R Holtgrave
    Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS Med 4:e194. 2007
  8. ncbi Diagnostic test accuracy may vary with prevalence: implications for evidence-based diagnosis
    Mariska M G Leeflang
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Epidemiol 62:5-12. 2009
  9. pmc Determinants of the accuracy of rapid diagnostic tests in malaria case management: evidence from low and moderate transmission settings in the East African highlands
    Tarekegn A Abeku
    London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Malar J 7:202. 2008
  10. ncbi Economic advantage of a community-based malaria management program in the Brazilian Amazon
    L W Pang
    Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 65:883-6. 2001

Detail Information

Publications213 found, 100 shown here

  1. pmc Cost-effectiveness of malaria diagnostic methods in sub-Saharan Africa in an era of combination therapy
    Samuel Shillcutt
    Andean Health and Development Saludesa, Quito, Ecuador
    Bull World Health Organ 86:101-10. 2008
    ..To evaluate the relative cost-effectiveness in different sub-Saharan African settings of presumptive treatment, field-standard microscopy and rapid diagnostic tests (RDTs) to diagnose malaria...
  2. ncbi Empirical evidence of design-related bias in studies of diagnostic tests
    J G Lijmer
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, The Netherlands
    JAMA 282:1061-6. 1999
    ..The literature contains a large number of potential biases in the evaluation of diagnostic tests. Strict application of appropriate methodological criteria would invalidate the clinical application of most study results...
  3. pmc Influence of rapid malaria diagnostic tests on treatment and health outcome in fever patients, Zanzibar: a crossover validation study
    Mwinyi I Msellem
    Malaria Control Programme, Ministry of Health and Social Welfare, Zanzibar, Tanzania
    PLoS Med 6:e1000070. 2009
    ..Our objective was to study the influence of RDT-aided malaria diagnosis on drug prescriptions, health outcomes, and costs in primary health care settings...
  4. pmc Grading quality of evidence and strength of recommendations for diagnostic tests and strategies
    Holger J Schunemann
    Department of Epidemiology, Italian National Cancer Institute Regina Elena, 00144 Rome, Italy
    BMJ 336:1106-10. 2008
  5. pmc Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda
    Daniel J Kyabayinze
    Malaria Consortium Africa, Plot 2, Sturrock Road, P O Box 8045, Kampala, Uganda
    Malar J 7:221. 2008
    ..An assessment of the accuracy of Malaria Pf immuno-chromatographic test (ICT) and description of persistent antigenicity of HRP2 RDTs was undertaken in a hyperendemic area of Uganda...
  6. pmc Dispensary level pilot implementation of rapid diagnostic tests: an evaluation of RDT acceptance and usage by providers and patients--Tanzania, 2005
    Holly Ann Williams
    International Emergency and Refugee Health Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Malar J 7:239. 2008
    ..Without understanding operational issues or acceptance and usage by providers and patients, the costs of these tests may not be justified...
  7. pmc Costs and consequences of the US Centers for Disease Control and Prevention's recommendations for opt-out HIV testing
    David R Holtgrave
    Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS Med 4:e194. 2007
    ..In this paper, I estimate the costs and public health impact of opt-out HIV testing relative to testing accompanied by client-centered counseling, and relative to a more targeted counseling and testing strategy...
  8. ncbi Diagnostic test accuracy may vary with prevalence: implications for evidence-based diagnosis
    Mariska M G Leeflang
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Epidemiol 62:5-12. 2009
    ..Several studies and systematic reviews have reported results that indicate that sensitivity and specificity may vary with prevalence...
  9. pmc Determinants of the accuracy of rapid diagnostic tests in malaria case management: evidence from low and moderate transmission settings in the East African highlands
    Tarekegn A Abeku
    London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK
    Malar J 7:202. 2008
    ..HRP2-based RDTs are highly sensitive and stable; however, their specificity is a cause for concern, particularly in areas of intense malaria transmission due to persistence of HRP2 antigens from previous infections...
  10. ncbi Economic advantage of a community-based malaria management program in the Brazilian Amazon
    L W Pang
    Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 65:883-6. 2001
    ..A community-based program incorporating dipstick tests for malaria management can have economic advantages...
  11. ncbi A utilization management intervention to reduce unnecessary testing in the coronary care unit
    Thomas J Wang
    Massachusetts General Hospital, Wang Ambulatory Care Center 478, 15 Parkman St, Boston, MA 02114, USA
    Arch Intern Med 162:1885-90. 2002
    ..There have been no studies of interventions to reduce test utilization in the coronary care unit...
  12. pmc The effect of physicians' long-term use of CPOE on their test management work practices
    Joanne L Callen
    Faculty of Health Sciences, University of Sydney, PO Box 170, Lidcombe NSW 1825 Australia
    J Am Med Inform Assoc 13:643-52. 2006
    ..To explore physicians' work practices in relation to their long-term use of a computerized physician order entry system (CPOE)...
  13. pmc Cost effectiveness of diagnostic strategies for patients with acute, undifferentiated chest pain
    S Goodacre
    School of Health and Related Research, Sheffield University, UK
    Emerg Med J 20:429-33. 2003
    ..This paper aimed to estimate the relative cost effectiveness of these strategies...
  14. pmc Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria
    Elizabeth A Ashley
    Epicentre, Paris, France
    Malar J 8:241. 2009
    ..In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH)...
  15. ncbi A readers' guide to the interpretation of diagnostic test properties: clinical example of sepsis
    Joachim E Fischer
    Department of Pediatrics, University Children s Hospital, Steinweisstrasse 75, 8032, Zurich, Switzerland
    Intensive Care Med 29:1043-51. 2003
    ..In neonatology and pediatric intensive care the early diagnosis of potentially life-threatening infections is a particularly important issue...
  16. pmc Assessment of the prozone effect in malaria rapid diagnostic tests
    Philippe Gillet
    Department of Clinical Sciences, Institute of Tropical Medicine ITM, Nationalestraat 155, B 2000 Antwerp, Belgium
    Malar J 8:271. 2009
    ..In this study, a panel of malaria RDTs was challenged with clinical samples with P. falciparum hyperparasitaemia (> 5% infected red blood cells)...
  17. ncbi Women who are recalled for further investigation for breast screening: psychological consequences 3 years after recall and factors affecting re-attendance
    J Brett
    Division of Public Health and Primary Health Care, University of Oxford, Institute of Health Sciences, Headington
    J Public Health Med 23:292-300. 2001
    ..Having undergone further investigations did not necessarily motivate women to attend for their next routine appointment, with 15 per cent of these women not returning for routine screening 3 years on...
  18. ncbi Attitudes to HIV voluntary counselling and testing among mineworkers in South Africa: will availability of antiretroviral therapy encourage testing?
    J H Day
    Aurun Health Research, Welkom, South Africa
    AIDS Care 15:665-72. 2003
    ..A vigorous community education programme is essential if the introduction of ART is to be effective in promoting uptake of VCT...
  19. ncbi Evaluation of the performance of CareStart Malaria Pf/Pv Combo rapid diagnostic test for the diagnosis of malaria in Jimma, southwestern Ethiopia
    Zeleke Mekonnen
    School of Medical Lab Sciences, Faculty of Medical Sciences, Jimma University, Jimma, Ethiopia
    Acta Trop 113:285-8. 2010
    ..To evaluate the diagnostic performance of CareStart Malaria Pf/Pv Combo test relative to microscopy, for the diagnosis of falciparum and vivax malaria in Ethiopia...
  20. ncbi Predictors of colorectal cancer screening participation in the United States
    George N Ioannou
    Health Services Research, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Gastroenterol 98:2082-91. 2003
    ..Our aim was to identify predictors of colorectal cancer screening in the United States and subgroups with particularly low rates of screening...
  21. ncbi Prognosis of chronic or recurrent abdominal pain in children
    Marieke J Gieteling
    Department of General Practice, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Pediatr Gastroenterol Nutr 47:316-26. 2008
    ..Thus far a causal relation between these abnormalities and CAP has not been established. The additional prognostic value of extensive testing of children with CAP is a subject of debate...
  22. pmc Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow-up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone
    Sibylle Gerstl
    Médecins Sans Frontières MSF UK, 67 74 Saffron Hill, London EC 1N 8QX, UK
    Malar J 9:28. 2010
  23. pmc Test characteristics of two rapid antigen detection tests (SD FK50 and SD FK60) for the diagnosis of malaria in returned travellers
    Mirna Van der Palen
    Faculty of Health, Medicine and Life Sciences FHML, Maastricht, The Netherlands
    Malar J 8:90. 2009
    ..Two malaria rapid diagnostic tests were evaluated in a travel clinic setting: the SD FK50 Malaria Ag Plasmodium falciparum test (a two-band test) and the SD FK60 Malaria Ag P. falciparum/Pan test (a three-band test)...
  24. pmc Should countries implementing an artemisinin-based combination malaria treatment policy also introduce rapid diagnostic tests?
    Charlotte M Zikusooka
    Health Economics Unit, Department of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory, 7925 Cape Town, South Africa
    Malar J 7:176. 2008
    ..This motivates for this assessment of the cost-effectiveness of routine use of rapid diagnostic tests (RDTs) as an integral part of deploying artemisinin-based combination therapies (ACTs)...
  25. ncbi Selective ordering of preoperative investigations by anesthesiologists reduces the number and cost of tests
    Barry A Finegan
    Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada
    Can J Anaesth 52:575-80. 2005
    ..Preoperative investigations are frequently ordered according to care maps or protocols. We hypothesized that selective ordering of investigations by anesthesiology staff would reduce the number and cost of testing...
  26. pmc Cost-effectiveness analysis of rapid diagnostic test, microscopy and syndromic approach in the diagnosis of malaria in Nigeria: implications for scaling-up deployment of ACT
    Benjamin S C Uzochukwu
    Department of Community Medicine, University of Nigeria, Nigeria
    Malar J 8:265. 2009
    ..The study hence compares the cost-effectiveness of RDT versus syndromic diagnosis and microscopy...
  27. pmc An interactive model for the assessment of the economic costs and benefits of different rapid diagnostic tests for malaria
    Yoel Lubell
    Department of Public Health and Policy, LSHTM, London, UK
    Malar J 7:21. 2008
    ..The model presented (available online) can be used by decision makers to evaluate alternative RDTs and assess the circumstances under which their use is justified on economic grounds...
  28. ncbi Evidence-based emergency medicine/skills for evidence-based emergency care. Interval likelihood ratios: another advantage for the evidence-based diagnostician
    Michael D Brown
    Grand Rapids MERC Michigan State University Program in Emergency Medicine, Grand Rapids, MI, USA
    Ann Emerg Med 42:292-7. 2003
    ..Authors and journals need to be encouraged to report the results of studies of performance of diagnostic tests using interval ranges rather than simple dichotomization when the tests involve continuous variables...
  29. ncbi Why do primary care physicians in the United States and France order prostate-specific antigen tests for asymptomatic patients?
    Paul Clay Sorum
    Department of Medicine, Albany Medical Center, Albany, NY, USA
    Med Decis Making 23:301-13. 2003
    ..To understand why many primary care physicians in the United States and France order prostate-specific antigen (PSA) tests routinely for their asymptomatic male patients despite "evidence-based" recommendations...
  30. ncbi Can we abandon daily routine chest radiography in intensive care patients?
    Marleen E Graat
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    J Intensive Care Med 20:238-46. 2005
    ..The debate about discontinuing daily routine chest radiographs in the ICU is still not settled...
  31. pmc Evaluation of the SD FK70 malaria Ag Plasmodium vivax rapid diagnostic test in a non-endemic setting
    Philippe Gillet
    Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
    Malar J 8:129. 2009
  32. ncbi Prognostic implications of admission inflammatory profile in acute ischemic neurological events
    T Anuk
    Department of Neurology and the Stroke Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Acta Neurol Scand 106:196-9. 2002
    ..To reveal the potential prognostic implications of admission inflammatory markers in patients with acute ischemic neurological events...
  33. pmc An introduction to power and sample size estimation
    S R Jones
    North Manchester Hospital, Manchester, UK
    Emerg Med J 20:453-8. 2003
    ..The importance of power and sample size estimation for study design and analysis...
  34. ncbi Diagnosis of imported malaria by Plasmodium lactate dehydrogenase (pLDH) and histidine-rich protein 2 (PfHRP-2)-based immunocapture assays
    J Iqbal
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat
    Am J Trop Med Hyg 64:20-3. 2001
    ..Though the immunocapture diagnostic assays may be helpful in certain situations, microscopy of thick blood film is still the method of choice in diagnosing imported malaria...
  35. pmc Latent tuberculosis in HIV positive, diagnosed by the M. tuberculosis specific interferon-gamma test
    Inger Brock
    Department for Infectious Diseases, University Hospital, Hvidovre 2650, Denmark
    Respir Res 7:56. 2006
    ..We here report the results from the first patients screened...
  36. ncbi Operational response to malaria epidemics: are rapid diagnostic tests cost-effective?
    Estelle Rolland
    Epicentre, Paris, France
    Trop Med Int Health 11:398-408. 2006
    ..To compare the cost-effectiveness of malaria treatment based on presumptive diagnosis with that of malaria treatment based on rapid diagnostic tests (RDTs)...
  37. ncbi [The increased availability of self-tests for medical analyses]
    M Deutekom
    Academisch Medisch Centrum Universiteit van Amsterdam, Afd Klinische Epidemiologie en Biostatistiek, J1b 210 1, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 151:901-4. 2007
    ..In other cases false negative test results may delay necessary treatment. Further exploration of the use, sensitivity, specificity, benefits and harms of specific tests is warranted...
  38. ncbi Is molecular biology the best alternative for diagnosis of malaria to microscopy? A comparison between microscopy, antigen detection and molecular tests in rural Kenya and urban Tanzania
    P Mens
    KIT Biomedical Research, Koninklijk Instituut voor de Tropen KIT Royal Tropical Institute, Amsterdam, The Netherlands
    Trop Med Int Health 12:238-44. 2007
    ..To assess the agreement of different diagnostic methods for the diagnosis and confirmation of the clinical suspicion of Plasmodium infection in children in Tanzania and Kenya...
  39. ncbi Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London, London, UK
    AIDS 19:2038-41. 2005
    ..ELISPOT test performance appears to be independent of HIV-associated immunosuppression...
  40. ncbi Potential factors that may affect acceptance of routine prenatal HIV testing
    Fu Lin Wang
    Health Surveillance, Alberta Health and Wellness, 24th Floor, TELUS Plaza North Tower 10025 Jasper Ave, PO Box 1360 STN Main, Edmonton, AB T5J 2N3
    Can J Public Health 96:60-4. 2005
    ..Despite increasing advocacy for an "opt-out" strategy in routine prenatal HIV screening programs in Canada, no published studies have examined factors that may affect acceptance of prenatal HIV testing...
  41. ncbi End-user errors in applying two malaria rapid diagnostic tests in a remote area of Sudan
    Osama M E Seidahmed
    National Malaria Control Program, Khartoum, Sudan
    Trop Med Int Health 13:406-9. 2008
    ..End-user errors were more frequent with OptiMAL IT than Core Pf tests. To improve malaria diagnosis with rapid tests, users require training and better manufacturer's instructions that take into account local conditions...
  42. ncbi Use of a histidine-rich protein 2-based rapid diagnostic test for malaria by health personnel during routine consultation of febrile outpatients in a peripheral health facility in Yaounde, Cameroon
    Collins Sayang
    Centre de Formation et Recherche en Médecine et Santé Tropicale, Faculte de Medecine Nord, Boulevard Dramard 13015 Marseille, France
    Am J Trop Med Hyg 81:343-7. 2009
  43. ncbi Triple Faeces Test: an effective tool for detection of intestinal parasites in routine clinical practice
    T van Gool
    Section of Parasitology, Department of Medical Microbiology, L1 110, Academic Medical Centre, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Eur J Clin Microbiol Infect Dis 22:284-90. 2003
    ..The results of this study suggest that the TFT is an effective method for detection of intestinal parasites in stool samples in routine clinical practice...
  44. ncbi Malaria rapid diagnostic tests in tropical climates: the need for a cool chain
    Pernille Jorgensen
    World Health Organization Regional Office for the Western Pacific, Manila, The Philippines
    Am J Trop Med Hyg 74:750-4. 2006
    ..These results emphasize the need for good logistical planning during the introduction of point-of-care tests in tropical countries and the importance of considering the stability of diagnostic tests during procurement...
  45. ncbi Patterns and predictors of colorectal cancer test use in the adult U.S. population
    Laura C Seeff
    Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3717, USA
    Cancer 100:2093-103. 2004
    ..Screening is effective in reducing the incidence and mortality of colorectal cancer. Rates of colorectal cancer test use continue to be low...
  46. ncbi Neglected tests for neglected patients
    Martine Usdin
    MSF Campaign for Access to Essential Medicines, 4 rue St Sabin, 75011 Paris, France
    Nature 441:283-4. 2006
  47. ncbi Outpatient preanaesthesia evaluation clinics
    E Lew
    Department of Anaesthesia, KK Women s and Children s Hospital, 100 Bukit Timah Road, Singapore 229899
    Singapore Med J 45:509-16. 2004
    ..This review describes the structure of modern outpatient preanaesthesia evaluation clinics, and the associated benefits, limitations and controversies...
  48. ncbi [Cost-effectiveness ratio of using rapid tests for malaria diagnosis in the Peruvian Amazon]
    Angel Martín Rosas Aguirre
    Proyecto VIGIA, Ministerio de Salud del Perú Agencia de Estados Unidos para el Desarrollo Internacional, Lima, Peru
    Rev Panam Salud Publica 25:377-88. 2009
    ..To determine the cost-effectiveness ratios of three options for diagnosing malaria at the local health provider in 50 communities near the Peruvian Amazon...
  49. ncbi Fecal occult blood test use by Kansas medicare beneficiaries
    K K Engelman
    Department of Preventive Medicine, School of Medicine, University of Kansas, Kansas City 66160 7313, USA
    Prev Med 33:622-6. 2001
    ..The aim of this study was to examine utilization of and trends in fecal occult blood testing (FOBT) among beneficiaries since Medicare began FOBT coverage on January 1, 1998...
  50. ncbi Role of pre-surgical breast MRI in the management of invasive breast carcinoma
    Chiara Del Frate
    Institute of Radiology, University of Udine, P le Santa Maria della Misericordia, 33100 Udine, Italy
    Breast 16:469-81. 2007
    ..8%. In conclusion, breast MRI determines a significant change in the management of patients affected by invasive breast carcinoma, particularly in patients eligible for conservative surgery after standard breast examination...
  51. ncbi Diagnostic value of Tl-201 lung uptake is dependent on measurement method
    A Hitzel
    , CHU de Rouen et Centre Henri Becquerel, and Service de Cardiologie, CHU de Rouen, , Rouen, France
    J Nucl Cardiol 8:332-8. 2001
    ..CONCLUSIONS: The methodology of LHR measurement significantly influences the clinical contribution of Tl-201 lung uptake evaluation. Optimal reproducibility and diagnostic accuracy are provided by a right lung ROI...
  52. ncbi Predicting prolonged dysphagia in acute stroke: the Royal Adelaide Prognostic Index for Dysphagic Stroke (RAPIDS)
    Simon Broadley
    Department of Neurology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia
    Dysphagia 20:303-10. 2005
    ..We conclude that the RAPIDS test can be used early to identify patients likely to have prolonged dysphagia. This test could form a basis for selection of patients for trials of nonoral feeding methods...
  53. ncbi Lumbar elastance and resistance to CSF outflow correlated to patency of the cranial subarachnoid space and clinical outcome of endoscopic third ventriculostomy in obstructive hydrocephalus
    R Bech-Azeddine
    University Clinic of Neurosurgery, The Neuroscience Center, Rigshospitalet, Glostrup, Denmark
    Minim Invasive Neurosurg 50:189-94. 2007
  54. ncbi Patient's and doctors' delays in the diagnosis of chest tumors
    Hirsh Koyi
    Department of Respiratory Medicine, Gaevle County Hospital, S 80187, Gaevle, Sweden
    Lung Cancer 35:53-7. 2002
    ..It is well known that there are delays in diagnosis of lung cancer, both from the patients and from the doctors. We decided to prospectively study this in our area...
  55. ncbi The predictive value of the pediatric symptom checklist in 5-year-old Austrian children
    Leonhard Thun-Hohenstein
    Institute for Research and Education in Child and Adolescent Neuropsychiatry KNIFFF, Salzburg, Austria
    Eur J Pediatr 167:323-9. 2008
    ..2%) and sensitivity (81.1%) were obtained at a cut-off value of 15.5. This cut-off would allow 24.6% to be detected as impaired, which is somewhat above the frequency (20.2%) found by CBCL...
  56. ncbi Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System, Richmond, VA 23298 0341, USA
    Hepatology 43:1317-25. 2006
    ..In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV-coinfected patients...
  57. ncbi Comparison of simple tests for the non-invasive diagnosis of clinically silent cirrhosis in chronic hepatitis C
    G Borroni
    Dipartimento Dipendenze, ASL Provincia di Milano 1, Legnano MI, Italy
    Aliment Pharmacol Ther 24:797-804. 2006
    ..Alternative non-invasive methods have been developed but their usefulness remains uncertain...
  58. ncbi Evaluation of three rapid diagnostic tests for cholera: does the skill level of the technician matter?
    Pavani Kalluri
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Trop Med Int Health 11:49-55. 2006
    ..To evaluate SMART, Medicos Dip Stick and an Institut Pasteur (IP) cholera dipstick tests for accuracy and ease of use...
  59. ncbi Correlation between serum-ascites albumin concentration gradient with gastrointestinal bleeding in patients of portal hypertension
    Anirudh Mene
    GI Surgery Unit, Department of Surgery, NSCB Government Medical College and Allied Hospitals, Jabalpur MP, India 482003
    Trop Doct 33:39-41. 2003
    ..The results of the present study are encouraging for clinicians working in developing countries and may help in optimizing prophylactic therapy and where available, improving the cost effectiveness of screening endoscopy...
  60. ncbi Evaluation of the Ez-HBT Helicobacter blood test to establish Helicobacter pylori eradication
    F Ahmed
    Division of Gastroenterology, Syracuse VA Medical Center, Syracuse, NY 10128, USA
    Aliment Pharmacol Ther 22:875-80. 2005
    ..The urea blood test (Ez-HBT) has been shown to compare favourably with the urea breath test in the diagnosis of active Helicobacter pylori infection...
  61. ncbi Admission ambulation velocity predicts length of stay and discharge disposition following stroke in an acute rehabilitation hospital
    Meheroz H Rabadi
    Burke Rehabilitation Hospital, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Neurorehabil Neural Repair 19:20-6. 2005
    ..The effect of admission ambulation velocity on length of stay and discharge disposition has not been previously reported...
  62. ncbi A comparison of different balance tests in the prediction of falls in older women with vertebral fractures: a cohort study
    Rob Morris
    Nottingham City Hospital, UK
    Age Ageing 36:78-83. 2007
    ..people with vertebral fractures are at high risk of developing hip fractures. Falls risk is important in the pathogenesis of hip fractures...
  63. ncbi Provocative tests in different stages of carpal tunnel syndrome
    M Mondelli
    Servizio di EMG, Azienda Sanitaria Locale n.7 di Siena, Siena, Italy
    Clin Neurol Neurosurg 103:178-83. 2001
    ..This correlation may also explain the contradictory results in the literature...
  64. ncbi The octreotide test dose is not a reliable predictor of the subsequent response to somatostatin analogue therapy in patients with acromegaly
    Ana Pokrajac
    Christie Hospital NHS Trust, Department of Endocrinology, Wilmslow Road, Withington, Manchester M20 4BX, UK
    Eur J Endocrinol 154:267-74. 2006
    ..In conclusion, our data indicate that the octreotide TD has no place in selecting patients for SAT...
  65. ncbi Association between transferrin receptor-ferritin index and conventional measures of iron responsiveness in hemodialysis patients
    Yen Cheng Chen
    Institutes of Physiology and Clinical Medicine, Faculty of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Am J Kidney Dis 47:1036-44. 2006
  66. ncbi Barriers to colorectal cancer screening: a comparison of reports from primary care physicians and average-risk adults
    Carrie N Klabunde
    Health Services and Economics Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892 7344, USA
    Med Care 43:939-44. 2005
    ..Barriers to colorectal cancer (CRC) screening are not well understood...
  67. ncbi MR diffusion-weighted imaging and outcome prediction after ischemic stroke
    P J Hand
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Neurology 66:1159-63. 2006
    ..MR diffusion-weighted imaging (DWI) shows acute ischemic lesions early after stroke so it might improve outcome prediction and reduce sample sizes in stroke treatment trials. Previous studies of DWI and outcome produced conflicting results...
  68. ncbi The use of screening colonoscopy for patients cared for by the Department of Veterans Affairs
    Hashem B El-Serag
    Houston Center for Quality of Care and Utilization Studies, Michael E DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Intern Med 166:2202-8. 2006
    ..Because of differences in the delivery of health care, this trend in use of colonoscopy in fee-for-service settings might not be paralleled in the Department of Veterans Affairs (VA)...
  69. ncbi Routine prostate screening may be unnecessary and harmful
    Deborah Levenson
    Rep Med Guidel Outcomes Res 14:5-7. 2003
  70. ncbi Endoscopy plays an important preoperative role in bariatric surgery
    Ravi N Sharaf
    Division of Gastroenterology and Department of Surgery, New York University School of Medicine, New York, NY, USA
    Obes Surg 14:1367-72. 2004
    ..The role of upper endoscopy (EGD) in obese patients prior to bariatric surgery is controversial. The aim of this study was to evaluate the diagnostic yield and cost of routine EGD before bariatric surgery...
  71. ncbi Clinical evaluation for cancer in patients with involuntary weight loss without specific symptoms
    Jose L Hernandez
    Department of Internal Medicine, Hospital Marques de Valdecilla, University of Cantabria, 39008 Santander, Spain
    Am J Med 114:631-7. 2003
    ..We sought to evaluate the efficiency of various diagnostic studies used in these patients...
  72. ncbi Sensitivity of routine intensive care unit surveillance for detecting myocardial ischemia
    Elizabeth A Martinez
    The Johns Hopkins University School of Medicine, Department of Anesthesiology Critical Care Medicine, USA
    Crit Care Med 31:2302-8. 2003
  73. ncbi A comparison of routine cytology and fluorescence in situ hybridization for the detection of malignant bile duct strictures
    Benjamin R Kipp
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Gastroenterol 99:1675-81. 2004
    ..The aim of this study was to assess the relative sensitivities and specificities of fluorescence in situ hybridization (FISH) and routine cytology for the detection of malignancy in biliary tract strictures...
  74. ncbi Routine preoperative abdominal computed tomography in colon cancer: a utility study
    A P Zbar
    School of Clinical Medicine and Research, Queen Elizabeth Hospital University of the West Indies, Martindales Road, St Michael, Barbados
    Tech Coloproctol 11:105-9. 2007
    ..A prospective study was conducted where CT was preoperatively incorporated into the management algorithm to ascertain its role in patient treatment...
  75. ncbi Assessment of the routine, occupation-based gonorrhea and syphilis screening program in Moscow, Russia: an analysis of sexually transmitted infection prevalence and cost-effectiveness
    Ekaterina V Kourbatova
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Sex Transm Dis 35:453-60. 2008
    ..Objectives of our study were to determine the prevalence of syphilis and gonorrhea in the screened occupational groups in Moscow and to conduct a cost-effectiveness evaluation of the occupational screening program...
  76. ncbi ESR or CRP? A comparison of their clinical utility
    A Osei-Bimpong
    Department of Haematology, Hammersmith Hospital, London, UK
    Hematology 12:353-7. 2007
  77. ncbi A multitest regimen of pain provocation tests as an aid to reduce unnecessary minimally invasive sacroiliac joint procedures
    Peter Van der Wurff
    Division of Perioperative Medicine and Emergency Medicine, Department of Anesthesiology and Pain Treatment, University Medical Centre Utrecht, Utrecht, The Netherlands
    Arch Phys Med Rehabil 87:10-4. 2006
  78. ncbi Multi-slice spiral CT in routine diagnosis of suspected acute left-sided colonic diverticulitis: a prospective study of 120 patients
    A Werner
    Institut fur Klinische Radiologie, Universitatsklinikum Mannheim, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Eur Radiol 13:2596-603. 2003
    ..Multi-slice CT is reliable in detecting diverticulitis, including extracolic complications, and often reveals other diagnoses; therefore, MSCT is recommended as standard diagnostic procedure in suspected acute diverticulitis...
  79. ncbi Value of routine clinical tests in predicting the development of infected pancreatic necrosis in severe acute pancreatitis
    Zilvinas Dambrauskas
    Laboratory for Research of the GI Tract, Institute for Biomedical Research, Kaunas University of Medicine, Kaunas, Lithuania
    Scand J Gastroenterol 42:1256-64. 2007
    ..Our objective was to assess the value of routine clinical tests to determine the minimal risk for infected necrosis, thereby optimizing timing and selection of patients for image-guided FNA...
  80. ncbi Performance and costs of a rapid syphilis test in an urban population at high risk for sexually transmitted infections
    M M Gianino
    Department of Public Health and Microbiology, University of Turin, Italy
    J Prev Med Hyg 48:118-22. 2007
  81. ncbi Fibre diffraction from a single hair can provide an early non-invasive test for colon cancer
    Veronica J James
    Research School of Chemistry, Australian National University, Canberra and Fiberscan Pty Ltd, Kenthurst NSW, Australia
    Med Sci Monit 9:MT79-84. 2003
    ..Hair samples from controls, patients with cancers of the breast and other sites including the colon were studied. An associated study of collagenous colon tissue was also undertaken...
  82. ncbi Methods for the measurement of nutrition impact and adaptation of laboratory methods into field settings to enhance and support community-based nutrition research
    Noel W Solomons
    Center for Studies of Sensory Impairment, Aging and Metabolism, Guatemala City, Guatemala
    Nutr Rev 60:S126-31. 2002
    ..As with more complex and formal assays, the principles of accuracy, reliability, and construct validity need to be applied...
  83. ncbi [Sensitivity, specificity, positive and negative predictive value of a diagnostic test]
    M R Nendaz
    Clinique de Médecine 1, Hopitaux Universitaires de Geneve, Suisse
    Rev Mal Respir 21:390-3. 2004
  84. ncbi Routine preoperative carotid duplex scanning in patients undergoing open heart surgery: is it worthwhile?
    E Ascher
    Division of Vascular Surgery, Maimonides Medical Center, 4802 Tenth Avenue, Brooklyn, N York 11219, USA
    Ann Vasc Surg 15:669-78. 2001
    ..However, carotid screening is recommended for all patients undergoing open heart operations who are over the age of 60 years old, regardless of the absence of associated risk factors...
  85. ncbi Biochemical screening in the assessment of erectile dysfunction: what tests decide future therapy?
    Carolyn M Earle
    Keogh Institute for Medical Research, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    Urology 62:727-31. 2003
    ..To evaluate which biochemical tests, performed as screening tests in the assessment of erectile dysfunction (ED), lead to a change in standard treatment...
  86. ncbi Cost of routine screening for carotid and lower extremity occlusive disease in patients with abdominal aortic aneurysms
    David A Axelrod
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, 48109 0604, USA
    J Vasc Surg 35:754-8. 2002
    ..Furthermore, the cost-effectiveness of routine versus selective preoperative noninvasive examination of the carotid and lower extremity arterial beds has not been established in patients who undergo elective AAA repair...
  87. ncbi Baseline predictors of initiation vs. maintenance of regular mammography use among rural women
    Garth H Rauscher
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, 1603 West Taylor Street, 816 SPHPI M C 923, Chicago, IL 60612, USA
    Prev Med 40:822-30. 2005
  88. ncbi Prognostic value of routine preoperative electrocardiography in patients undergoing noncardiac surgery
    Peter G Noordzij
    Department of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Cardiol 97:1103-6. 2006
    ..5%. In conclusion, preoperative electrocardiography provides prognostic information in addition to clinical characteristics and the type of surgery. However, the usefulness of its routine use in lower risk surgery is questionable...
  89. ncbi Use of admission troponin in critically ill medical patients
    Ruth Minkin
    Department of Medicine, St Luke s Roosevelt Hospital Center, New York, New York, USA
    J Intensive Care Med 20:334-8. 2005
    ..115), or development of multiorgan failure (P = .64). The authors concluded that there is no benefit in obtaining a routine admission troponin level in MICU patients when an acute coronary event is not suspected...
  90. ncbi Predictive value of white blood cell count on admission for in-hospital mortality in acute stroke patients
    Radoslaw Kazmierski
    Department of Neurology, University of Medical Sciences, Przybyszewskiego 49, PL 60 355 Poznan, Poland
    Clin Neurol Neurosurg 107:38-43. 2004
    ..In the present study, we sought to determine the predictive value of white blood cell (WBC) count measured on admission for in-hospital death in acute stroke patients...
  91. ncbi Admission albumin levels and functional outcome of elderly hip fracture patients: is it that important?
    Eliyahu H Mizrahi
    Department of Geriatric Medicine and Rehabilitation, Sheba Medical Center, Tel Hashomer, 52621, Israel
    Aging Clin Exp Res 19:284-9. 2007
    ..The objective of this study was to evaluate to what extent admission albumin levels may affect the functional outcome of elderly hip fracture patients...
  92. ncbi Urinary tract infection and Chlamydia infection in adolescent females
    Jill S Huppert
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Pediatr Adolesc Gynecol 16:133-7. 2003
    ..To examine whether clinical or laboratory findings could distinguish Chlamydia trachomatis (CT) from urinary tract infection (UTI) among adolescent females in whom providers tested for both...
  93. ncbi Is routine fetal karyotyping necessary for patients undergoing amniocentesis for elevated maternal serum alpha-fetoprotein?
    D Gonzalez
    Department of Obstetrics, Gynecology and Women s Health, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 2714, USA
    J Matern Fetal Med 10:376-9. 2001
    ..The object of the study was to determine the necessity of routine fetal karyotyping in patients undergoing amniocentesis for elevated maternal serum alpha-fetoprotein (AFP)...
  94. ncbi Evaluation of outpatient hysteroscopy and ultrasonography in the diagnosis of endometrial disease
    T Justin Clark
    Minimal Access and Surgical Training MAST Centre, Academic Department of Obstetrics and Gynaecology, University of Birmingham, Birmingham, United Kingdom
    Obstet Gynecol 99:1001-7. 2002
    ..To develop a multivariable approach to determine the added value of tests in routine practice where some diagnostic information is already available from clinical history...
  95. ncbi Novel diagnostic test for acute stroke
    John R Lynch
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 35:57-63. 2004
    ..The objective of this study was to examine the feasibility of developing a diagnostic panel of blood-borne biochemical markers of cerebral ischemia...
  96. ncbi Summary receiver operating characteristic curve analysis techniques in the evaluation of diagnostic tests
    Catherine M Jones
    The National Heart and Lung Institute, Imperial College of Science, Technology, and Medicine, Department of Cardiothoracic Surgery, St Mary s Hospital, London, United Kingdom
    Ann Thorac Surg 79:16-20. 2005
    ..We use a practical approach to show how SROC analysis can be applied to meta-analysis of diagnostic accuracy by using a contrived dataset of studies on virtual bronchoscopy in the diagnosis of airway lesions...
  97. ncbi A single complete ultrasound investigation of the venous network for the diagnostic management of patients with a clinically suspected first episode of deep venous thrombosis of the lower limbs
    Antoine Elias
    Department of Vascular Medicine, Centre Hospitalier Universitaire Rangueil, Toulouse, France
    Thromb Haemost 89:221-7. 2003
    ..Integrating this method within diagnostic strategies for DVT could improve management and be more acceptable for patients and physicians...
  98. ncbi [ROC (receiver operating characteristics) curve: principles and application in biology]
    H Delacour
    Laboratoire de Biochimie, toxicologie cliniques, Hôpital d Instruction des Armées du Val de Grâce, Paris, France
    Ann Biol Clin (Paris) 63:145-54. 2005
    ..Used in numerous medical domains, this statistical tool is easily accessible thanks to the development of computer softwares. This article exposes the principles of construction and exploitation of a ROC curve...
  99. ncbi [Predictive value of preoperative tests in facectomy]
    Rodrigo Pessoa Cavalcanti Lira
    Departamento de Oftalmo Otorrinolaringologia, Universidade Estadual de Campinas, Campinas, SP, Brasil
    Rev Saude Publica 37:197-202. 2003
    ..To establish the prevalence of abnormal results in routine preoperative tests prior to facectomies and whether they influence the occurrence of perioperative clinical complications...
  100. pmc Accuracy of five different diagnostic techniques in mild-to-moderate pelvic inflammatory disease
    Hernando Gaitan
    Obstetrics and Gynecology Department, Universidad Nacional de Columbia, Bogota, Columbia
    Infect Dis Obstet Gynecol 10:171-80. 2002
    ..To evaluate the clinical diagnosis of pelvic inflammatory disease (PID) compared with the diagnosis of PID made by laparoscopy, endometrial biopsy, transvaginal ultrasound, and cervical and endometrial cultures...
  101. ncbi A clinical composite score accurately detects meniscal pathology
    Douglas J Lowery
    Orthopaedic Associates, Evansville, Indiana, USA
    Arthroscopy 22:1174-9. 2006
    ..We evaluated how effectively the composite examination, when performed in the presence of an anterior cruciate ligament (ACL) injury or degenerative joint disease (DJD), determined the presence of meniscal tears...

Research Grants76

  1. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    ..Candidate vaccine proteins will be screened, confirmed and selected for clinical trials using pioneering molecular tools and blood samples from pregnant African women and their infants. ..
  2. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..abstract_text> ..
  3. New Rapid Diagnostic Tests for Amebiasis
    JOEL F HERBEIN; Fiscal Year: 2010
  4. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..Understanding the frequency and etiology of bacterial infections following influenza will aid in pandemic planning. The data obtained from the proposed studies will be vital for evidence-based management of pneumonia in children. ..
    Douglas H Keefe; Fiscal Year: 2013
    ..The research also evaluates whether the test battery improves the accuracy of diagnosing middle-ear disease and of identifying hearing loss in adult patients who receive medications that may affect their hearing. ..
  6. Colitis Induced by immune responses to luminal bacteria-mouse
    Ryan B Sartor; Fiscal Year: 2012
  7. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..Successful completion of these studies would enable the development of prognostic and diagnostic tests for AD, and provide insights into the neuroendocrine mechanisms of AD. ..
  8. Biliary Atresia, Cholestatic Liver Diseases, and Cystic Fibrosis: Indiana Univers
    Jean Pappas Molleston; Fiscal Year: 2013
    ..Because these diseases are rare, multicenter collaborations like the CHILDREN network are crucial for studying these children and improving medical management and outcnmes. ..
  9. Diagnostic array for aseptic encephalitis
    Darrell P Chandler; Fiscal Year: 2011
    ..The underlying platform developed herein will likewise find broad application in many areas of infectious disease diagnostics. ..
  10. Colorado Center for Childhood Liver Disease Research and Education
    Ronald J Sokol; Fiscal Year: 2013
    ..We will also train the researchers of the future who will study these rare diseases. ..
  11. Acquisition of a MALDI-TOF/TOF MS for Glycomic and Lipidomic Research
    Larry S Schlesinger; Fiscal Year: 2010
    ..The ability to perform true precursor ion selected collision-induced dissociation (CID) on these samples will also allow for fine structure elucidation of complex mixtures. ..
  12. Rapid, Highly Multiplexed and Sensitive Blood Test for Drug-resistant Bacteria
    ARMIN H REITMAIR; Fiscal Year: 2010
  13. Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targets
    Yang Xia; Fiscal Year: 2010
    ..Strategies to prevent or effectively treat preeclampsia would result in healthier babies and healthier mothers. Research proposed here is likely to contribute significantly to this goal. ..
  14. Autoimmunity Against Novel Antigens in Neuropsychiatric Dysfunction
    Josep O Dalmau; Fiscal Year: 2013
    Hannah C Kinney; Fiscal Year: 2010
    ..abstract_text> ..
  16. Chicago Community-Acquired Pneumonia Consortium
    Richard G Wunderink; Fiscal Year: 2010
    ..This information is critical to design appropriate future prevention and treatment plans. ..
  17. HCV Strain Variation and HCC
    Andrea D Branch; Fiscal Year: 2012
  18. Novel Role for Sirtuin Signaling Mechanisms and Downstream Targets in Depression
    Deveroux Ferguson; Fiscal Year: 2013
  19. Proteome-wide screen for M. tuberculosis antigens
    Robert N Husson; Fiscal Year: 2010
    ..Earlier, simpler, and more sensitive and specific TB diagnosis could have a major impact on the identification and treatment of people with TB in the U.S. and worldwide. ..
  20. Maternal genitourinary infections and adverse perinatal outcomes
    Abdullah Hel Baqui; Fiscal Year: 2013
  21. Proteomic Identification of Actionable Biomarkers in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2010
    ..6% of the world population. This proposal will identify novel autoantibody and cytokine biomarkers for (i) early diagnosis, (ii) predicting disease severity, and (iii) guiding therapeutic decision making for the treatment of RA. ..
  22. Targeting Pneumococcal Virulence Factors in Otitis Media
    Honggao Yan; Fiscal Year: 2012
  23. Risk of Cancer in Incidental Findings Identified on Ultrasound Imaging
    Rebecca Smith-Bindman; Fiscal Year: 2013
    ..We will use the results of these analyses to develop evidence-based practice guidelines for the management of incidental findings identified on ultrasound imaging. ..
    Larry G Arlian; Fiscal Year: 2013
    ..Characterization and production of these important molecules will identify new targets for intervention and lead to the development of novel strategies for the diagnosis, treatment, and prevention of this disease. ..
  25. Role of LHX3 Protein Isoforms in Pituitary Development
    SIMON JAMES RHODES; Fiscal Year: 2012
    ..Further, clinical collaborations will continue to provide information that enhances our understanding of the basic mechanisms of pituitary development, thereby allowing the formulation of new research hypotheses. ..
  26. Point of care microfluidic diagnosis system for rapid and sensitive detection of
    Michel G Bergeron; Fiscal Year: 2013
    ..These POCTs will help public health authorities to define new operational strategies for both lab-based and field-based applications. ..
  27. Middle-ear Mechanics in Normal and Pathological Ears
    John J Rosowski; Fiscal Year: 2013
    ..The goal of our research is to understand sound transmission in normal and diseased middle ears, and to develop better diagnostic tests and surgical procedures for patients with middle-ear disease. ..
  28. A Proteomic Approach to Biomarker Discovery in Prion Disease
    Lingjun Li; Fiscal Year: 2009
  29. Comparative Effectiveness of Advanced Diagnostic Imaging for Hepatic Fibrosis
    Jayant A Talwalkar; Fiscal Year: 2010
    ..The proposed research has relevance to public health, because the fundamental mechanisms being investigated appear common for maintaining health and creating disease in human beings. ..
  30. GRADS Cooperative Research Project: JHU Clinical Center
    David R Moller; Fiscal Year: 2013
    ..These studies may establish links between specific clinical phenotypes, microbial etiologies, and common pathogenic mechanisms to provide a framework for new therapeutic approaches to sarcoidosis. ..
  31. Kinetics of Chromosome Synapsis During Meiosis
    Jennifer C Fung; Fiscal Year: 2013
    ..Such research may lead to new ideas for treatment of infertility or to development of diagnostic tests to detect potential problems of chromosome segregation early on before expensive medical and surgical treatments are attempted. ..
  32. Multiplex ALEX-based Test for Protease Activity Profiling in Arthritic Joints
    ARMIN H REITMAIR; Fiscal Year: 2013
    ..Phase II will be dedicated to assay expansion, miniaturization, and instrument prototype development. Sub- sequent technology commercialization will target pharmaceuticals, diagnostics, and basic research markets. ..
  33. NICHD Cooperative Multicenter Neonatal Research Network
    Abbot R Laptook; Fiscal Year: 2013
    ..Serious neonatal problems may also afflict infants born at term. This application uses a multi- center network to perform rigorous clinical research to improve the outcome of preterm and term infants. ..
  34. Diagnostic Tests and Immunotherapy of Sarcoidosis Using Mycobacterial Proteins
    David R Moller; Fiscal Year: 2012
  35. Discovery of a urine biomarker of HIV for noninvasive, point-of-care testing use
    Hans P Schlecht; Fiscal Year: 2011
    ..g., those previously vaccinated with candidate HIV vaccines. Upon accomplishment of this project, we will have furthered the development of methods for biomarker discovery in urine, which can then be applied to other infections. ..
  36. Evaluation of In Vitro Companion Diagnostic Monoclonal Antibodies for Use in a St
    Christopher Horvath; Fiscal Year: 2013
    ..Combined use of anti-DEspR companion diagnostic and therapeutic mAbs has the potential to alter oncology clinical practice, particularly in BCa/TNBC, as an addition to or advantage over existing treatments. ..
  37. Collaborative Pediatric Critical Care Research Network At Children's Hospital of
    Joseph A Carcillo; Fiscal Year: 2013
  38. Gut flora metabolism of dietary phosphatidylcholine and cardiovascular disease
    Stanley L Hazen; Fiscal Year: 2013
    Kurt T Barnhart; Fiscal Year: 2010
  40. MMDx: A rapid multiplexed matrix code diagnostic for real time epidemiology
    Lee Gehrke; Fiscal Year: 2013
    ..This proposal describes the design, construction, and testing of a novel diagnostic for concurrent detection of multiple pathogens in a setting where no specialized equipment or expertise is required. ..
  41. Cardiovascular and Prostatic Safety of Testosterone Therapy in Aging Males
    Stephen K Van Den Eeden; Fiscal Year: 2013
  42. Specificity and Validity of Oxidative Stress Model of Chronic Fatigue Syndrome
    Dikoma C Shungu; Fiscal Year: 2013
  43. Biomarkers of Vasospasm and Outcome following Subarachnoid Hemorrhage
    Sherry Hsiang Yi Chou; Fiscal Year: 2013
    ..This study uses novel technology to search for causes and potential cure of brain injury and disability caused by SAH. ..
  44. HPV Disease in the Era of HPV Vaccines
    Laura A Koutsky; Fiscal Year: 2010
    ..Findings from this project will inform clinician/patient interactions and development of prophylactic vaccine implementation and cervical cancer screening guidelines in populations of mid-adult women. ..
  45. Low Cost Multi-pathogen Laser Diagnostic for HIV and AIDS Co-Infections
    CHRISTOPHER JOHN MYATT; Fiscal Year: 2011
    ..The simplicity and low cost of the technology will facilitate the use of antiretroviral therapy, greatly prolonging the lives of those infected with HIV and reducing the burden of disease in populations where HIV is endemic. ..
  46. Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-Infected Ugandans
    JOHN LUCIAN DAVIS; Fiscal Year: 2012
    ..We are also trying to find out if a similar test can tell if these patients are getting better once they start treatment. ..
  47. Lipidated Mycobacterium tuberculosis biomarkers in clinical specimens
    Basil I Swanson; Fiscal Year: 2013
    ..This project arose directly from technology-seeking activities of investigators in the NIAID/DMID-funded TB Clinical Diagnostics Research Consortium contract. ..
  48. Mycobacterium Tuberculosis Lipoarabinomannan In Vivo
    Libin Shi; Fiscal Year: 2013
    ..The definition of the terminal ends of LAM in vivo will impact the future when a sensitive and specific anti-LAM antibody can be generated based on this study to enhance LAM based existing assays for use in resource poor regions. ..
  49. Optimized magnetic nanoparticle labels for ultra-sensitive sepsis diagnostics
    MARK S DIIORIO; Fiscal Year: 2011
    Mony J de Leon; Fiscal Year: 2013
    ..This project will test the hypothesis that validated biological markers for neurofibrillary tangle and amyloid plaque pathology contribute to FDG-PET in predicting future cognitive decline in cognitively normal subjects. ..
  51. A Caribbean Project for Clinical and Basic Neuroscience Research
    ..Thus, one of the major objectives of the SNRP 2 is to maintain and expand the existing cohort, which represents a unique platform for the study of neurological impairments in HIV+Latinos. ..
  52. A diagnostic instrument to manage hemostasis in chronic liver disease
    Francesco Viola; Fiscal Year: 2012
  53. Institutional Collaboration between LSTM and CDC and Prevention on Malaria(U01)
    FEIKO OLAF TER KUILE; Fiscal Year: 2013
    ..LSTM will also continue to provide technical advice to the World Health Organization (WHO) and Roll Back Malaria (RBM) in support of scaling up of malaria control interventions globally. ..
  54. Understanding Mechanisms that lead to Disparities in Trauma Outcomes
    Adil H Haider; Fiscal Year: 2013
    ..This study will give us valuable information that can be used to develop innovative solutions to help diminish and potentially eliminate health care disparities. ..
  55. Protein Biomarkers for Invasive Aspergillosis Diagnostics
    MARTA L FELDMESSER; Fiscal Year: 2013
    ..The accomplishment of these studies would provide novel diagnostic methods with potential for flexibility in response to particular clinical settings. ..
    Monica Shokeen; Fiscal Year: 2013
    ..These aims will help in the accurate assessment of early stage disease and treatment response by sensitive and specific VLA-4 targeted PET imaging. ..
  57. The Activation of ERBB3 Signaling as a Resistance Mechanism to Targeted Therapies
    Jeffrey A Engelman; Fiscal Year: 2013
    ..In this grant proposal, we aim to identify how these cancers become resistant so that we can design effective therapies to overcome this resistance and provide benefit to our patients. ..
  58. Multiplexed Protein &miRNA Biomarker-based Next-gen Test for Alzheimers Disease
    ARMIN H REITMAIR; Fiscal Year: 2013
  59. Metabolic Imaging of the Cardioprotective Effects of Alcohol and ALDH2 Activators
    Daniel M Spielman; Fiscal Year: 2013
    ..The ultimate clinical goal is to develop metabolic imaging of hyperpolarized pyruvate as a diagnostic tool both to optimize choice of treatment and to monitor response to therapy. ..
    KUMAR SUBRAMANIAN; Fiscal Year: 2012
  61. The Role of Gut and Skin Microbiome in Psoriatic Arthritis
    Jose U Scher; Fiscal Year: 2013
    ..The results could transform our understanding of the relationships between microbes and humans, and lead to innovative diagnostic tests and future treatments. ..
  62. Diversity and Dynamic Stability of the Ocular Surface Microbiome
    Russell N Van Gelder; Fiscal Year: 2013
    ..Additionally, the geographic separation of the two groups provides excellent opportunity for understanding the effect of locale on the OS biome. ..
    Charles Bennett; Fiscal Year: 2000
  64. Mulago Inpatient Noninvasive Diagnosis of Pneumocystis Pneumonia (MIND PCP) Study
    John Davis; Fiscal Year: 2007
    ..This study will test if DNA- fingerprinting of special mouthwashes can accurately diagnose HIV-related pneumonia, and save lives. [unreadable] [unreadable] [unreadable]..
    Sandra Carson; Fiscal Year: 1990
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  67. A finger-prick medical diagnostic for vitamin B12 malabsorption: An early interv
    STEPHEN DUEKER; Fiscal Year: 2006
    ..The work is significant as it would lead to a needed convenient diagnostic test for the clinical B12 malabsorption that can be employed in the clinic or in research settings. [unreadable] [unreadable] [unreadable]..
  68. Diagnostic Biomarkers for Radicular Pain
    GAETANO JOHN SCUDERI; Fiscal Year: 2010
    ..In addition, Cytonics will obtain invaluable information on disease pathogenesis and biochemical targets for the expeditious development of a next generation diagnostic assay and pharmacotherapeutic(s). ..
    Richard Deyo; Fiscal Year: 1991
    ..Guidelines for use of these services will ge disseminated by professional and payer organizations and innovative CME efforts. New decision aids for both physicians and patients will incorporate data from all the assessment activities...
  70. Back pain Outcomes using Longitudinal Data (BOLD)
    Jeffrey G Jarvik; Fiscal Year: 2010
    RANDALL CEBUL; Fiscal Year: 1991
    ..The ultimate goal of this project is to examine this question and to rigorously test a promising approach to implementing the guidelines of experts...
    Brian Hjelle; Fiscal Year: 2001
  73. A finger-prick medical diagnostic for vitamin B12 malabsorption - An early interv
    STEPHEN DUEKER; Fiscal Year: 2009
    ..The work is significant as it would lead to a needed convenient diagnostic test for B12 malabsorption that can be employed in the clinic or in research settings. ..
  74. Symposium: Progress in Fanconi Anemia Research
    Grover Bagby; Fiscal Year: 2001
    ..A short narrative summary of meeting highlights will be created by the Chair of the Scientific Advisory Committee of the Fanconi Anemia Research Fund and will be published in the journal, Experimental Hematology. ..
  75. Improving Meta-Analysis of Diagnostic Test Studies
    Christopher Schmid; Fiscal Year: 2004
    ..These tasks will contribute to the development of recommendations for improving diagnostic test meta-analyses. ..
    A Washington; Fiscal Year: 1993
    ..The information generated and the analyses performed during this investigation will provide the necessary groundwork for the development and implementation of preference-based clinical guidelines for the use of prenatal diagnostics...