spirometry

Summary

Summary: Measurement of volume of air inhaled or exhaled by the lung.

Top Publications

  1. ncbi Standardisation of spirometry
    M R Miller
    University Hospital Birmingham NHS Trust, Birmingham, UK
    Eur Respir J 26:319-38. 2005
  2. ncbi Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol (1985) 104:394-403. 2008
  3. pmc Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations
    Philip H Quanjer
    Dept of Pulmonary Diseases and Dept of Paediatrics, Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands
    Eur Respir J 40:1324-43. 2012
  4. ncbi General considerations for lung function testing
    M R Miller
    University Hospital Birmingham NHS Trust, UK
    Eur Respir J 26:153-61. 2005
  5. ncbi New reference values for forced spirometry in white adults in Brazil
    Carlos Alberto de Castro Pereira
    Service of Pulmonology Department, Hospital do Servidor Publico Estadual, HSPE, Sao Paulo, SP, Brazil
    J Bras Pneumol 33:397-406. 2007
  6. ncbi Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society
    Amir Qaseem
    American College of Physicians and Temple University, Philadelphia, Pennsylvania 19106, USA
    Ann Intern Med 155:179-91. 2011
  7. ncbi Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease
    Masaharu Nishimura
    First Department of Medicine, Hokkaido University School of Medicine, and Center for Respiratory Diseases, Hokkaido Social Insurance Hospital, N 15 W 7, Kita ku, Sapporo 060 8638, Japan
    Am J Respir Crit Care Med 185:44-52. 2012
  8. pmc Asthma, chronic obstructive pulmonary disease, or both? Diagnostic labeling and spirometry in primary care patients aged 40 years or more
    Hasse Melbye
    General Practice Research Unit, Department of Community Medicine, University of Tromsø, Norway
    Int J Chron Obstruct Pulmon Dis 6:597-603. 2011
  9. ncbi Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination
    David M Mannino
    Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Med 114:758-62. 2003
  10. ncbi Minimal clinically important differences in COPD lung function
    James F Donohue
    Division of Pulmonary Diseases and Critical Care Medicine, School of Medicine, University of North Carolina at Chapel Hill, CB 7020, 4125 Bioinformatics Building, Chapel Hill, North Carolina 27599 7020, USA
    COPD 2:111-24. 2005

Detail Information

Publications288 found, 100 shown here

  1. ncbi Standardisation of spirometry
    M R Miller
    University Hospital Birmingham NHS Trust, Birmingham, UK
    Eur Respir J 26:319-38. 2005
  2. ncbi Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol (1985) 104:394-403. 2008
    ..We hypothesized that severe asthma has a characteristic physiology of airway obstruction, and we evaluated spirometry, lung volumes, and reversibility during a stable interval in 287 severe and 382 nonsevere asthma subjects from ..
  3. pmc Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations
    Philip H Quanjer
    Dept of Pulmonary Diseases and Dept of Paediatrics, Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands
    Eur Respir J 40:1324-43. 2012
    ..They can be applied globally to different ethnic groups. Additional data from the Indian subcontinent and Arabic, Polynesian and Latin American countries, as well as Africa will further improve these equations in the future...
  4. ncbi General considerations for lung function testing
    M R Miller
    University Hospital Birmingham NHS Trust, UK
    Eur Respir J 26:153-61. 2005
  5. ncbi New reference values for forced spirometry in white adults in Brazil
    Carlos Alberto de Castro Pereira
    Service of Pulmonology Department, Hospital do Servidor Publico Estadual, HSPE, Sao Paulo, SP, Brazil
    J Bras Pneumol 33:397-406. 2007
    ..To describe spirometric reference equations for healthy Brazilian adults who have never smoked and to compare the predicted values with those derived in 1992...
  6. ncbi Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society
    Amir Qaseem
    American College of Physicians and Temple University, Philadelphia, Pennsylvania 19106, USA
    Ann Intern Med 155:179-91. 2011
    ..addresses the value of history and physical examination for predicting airflow obstruction; the value of spirometry for screening or diagnosis of COPD; and COPD management strategies, specifically evaluation of various inhaled ..
  7. ncbi Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease
    Masaharu Nishimura
    First Department of Medicine, Hokkaido University School of Medicine, and Center for Respiratory Diseases, Hokkaido Social Insurance Hospital, N 15 W 7, Kita ku, Sapporo 060 8638, Japan
    Am J Respir Crit Care Med 185:44-52. 2012
    ..Although the rate of annual decline in FEV1 is one of the most important outcome measures in chronic obstructive pulmonary disease (COPD), little is known about intersubject variability based on clinical phenotypes...
  8. pmc Asthma, chronic obstructive pulmonary disease, or both? Diagnostic labeling and spirometry in primary care patients aged 40 years or more
    Hasse Melbye
    General Practice Research Unit, Department of Community Medicine, University of Tromsø, Norway
    Int J Chron Obstruct Pulmon Dis 6:597-603. 2011
    To describe symptoms and lung function in patients registered with asthma or chronic obstructive pulmonary disease (COPD) in primary care and to examine how spirometry findings fit with general practitioners' (GPs) diagnoses.
  9. ncbi Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination
    David M Mannino
    Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Med 114:758-62. 2003
  10. ncbi Minimal clinically important differences in COPD lung function
    James F Donohue
    Division of Pulmonary Diseases and Critical Care Medicine, School of Medicine, University of North Carolina at Chapel Hill, CB 7020, 4125 Bioinformatics Building, Chapel Hill, North Carolina 27599 7020, USA
    COPD 2:111-24. 2005
    ..Also distributional/statistical methods may be useful in determining the MCID FEV1...
  11. ncbi Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    Bartolome R Celli
    Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Am J Respir Crit Care Med 178:332-8. 2008
    ..Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in lung function. No drug has been shown conclusively to reduce this decline...
  12. pmc COPD diagnosis related to different guidelines and spirometry techniques
    Lennart Nathell
    Personal Injury Prevention Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Respir Res 8:89. 2007
    ..Those who smoked more than 8 cigarettes per day were invited to perform a spirometry. Totally 3,887 spirometries were performed. In this sample 10.2% fulfilled the NICE COPD-criteria, 14...
  13. ncbi Formoterol mono- and combination therapy with tiotropium in patients with COPD: a 6-month study
    Claus Vogelmeier
    Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Giessen und Marburg, Standort Marburg Baldingerstrasse, D 35043 Marburg, Germany
    Respir Med 102:1511-20. 2008
    ..Combined bronchodilator therapy may be a valuable treatment option for patients with COPD...
  14. ncbi Unrecognised ventricular dysfunction in COPD
    A Macchia
    Epidemiology Section, Dept of Internal Medicine, CEMIC Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina
    Eur Respir J 39:51-8. 2012
    ..patients with echocardiographically confirmed CHF (n=201) and stable ≥ 60-yr-old patients with clinically and spirometry-confirmed COPD (n=218)...
  15. pmc Percent emphysema, airflow obstruction, and impaired left ventricular filling
    R Graham Barr
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    N Engl J Med 362:217-27. 2010
    ....
  16. ncbi Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD
    J A Van Noord
    Dept of Respiratory Diseases, Atrium Medisch Centrum, Henri Dunantstraat 5, 6419 PC Heerlen, The Netherlands
    Eur Respir J 26:214-22. 2005
    ..d., formoterol 12 microg b.i.d. or both combined q.d. for three 6-week periods. The end-points were 24-h spirometry (FEV1, forced vital capacity (FVC)) at the end of each treatment, rescue salbutamol and safety...
  17. pmc Effect on smoking quit rate of telling patients their lung age: the Step2quit randomised controlled trial
    Gary Parkes
    The Limes Surgery, Hoddesdon, Hertfordshire EN11 8EP
    BMJ 336:598-600. 2008
    ..To evaluate the impact of telling patients their estimated spirometric lung age as an incentive to quit smoking...
  18. ncbi Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers
    J A Hardie
    Institute of Internal Medicine, Deaconess Hospital, University of Bergen, Norway
    Eur Respir J 20:1117-22. 2002
    ..dyspnoea or heart disease/hypertension complicated with dyspnoea, 71 were able to perform an acceptable spirometry. Approximately 35% of these healthy, elderly never-smokers had an FEV1/FVC% of <70% and would be classified ..
  19. ncbi Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD
    Jan A van Noord
    Department of Respiratory Diseases, Atrium Medisch Centrum, Henri Dunantstraat 5, 6419 PC Heerlen, The Netherlands
    Chest 129:509-17. 2006
    ..The combination of short-acting beta(2)-agonists and anticholinergics in the treatment of COPD has been well documented, but data on combination of long-acting agents are lacking...
  20. ncbi Pulmonary function testing in the diagnosis of asthma: a population study
    Andrea S Gershon
    Institute for Clinical Evaluative Sciences, Toronto, ON, M4N 3M5, Canada
    Chest 141:1190-6. 2012
    ..The proportion of people who have had objective pulmonary function testing around the time of diagnosis and factors associated with receiving testing are not well understood...
  21. pmc Performance of American Thoracic Society-recommended spirometry reference values in a multiethnic sample of adults: the multi-ethnic study of atherosclerosis (MESA) lung study
    John L Hankinson
    Hankinson Consulting, Inc, Valdosta, GA, USA
    Chest 137:138-45. 2010
    ..94 for Asian-Americans. We aimed to validate the NHANES III reference equations and the correction factor for Asian-Americans in an independent, multiethnic sample of US adults...
  22. pmc Overdiagnosis of asthma in obese and nonobese adults
    Shawn D Aaron
    Ottawa Health Research Institute, Ottawa, Ont, USA
    CMAJ 179:1121-31. 2008
    ..It is unclear whether asthma is overdiagnosed in developed countries, particularly among obese individuals, who may be more likely than nonobese people to experience dyspnea...
  23. ncbi Prevalence of chronic obstructive pulmonary disease in Korea: a population-based spirometry survey
    Dong Soon Kim
    Division of Pulmonary and Critical Care Medicine, Asan Medical Center, College of Medicine, University of Ulsan, 388 1, Poongnap dong, Songpa Gu, Seoul, South Korea
    Am J Respir Crit Care Med 172:842-7. 2005
    ..Although chronic obstructive pulmonary disease is a leading cause of mortality and morbidity worldwide, there are only limited data on its prevalence, especially in Asia...
  24. ncbi Hyperhomocysteinaemia predicts the decline in pulmonary function in healthy male smokers
    Keiko Nunomiya
    Dept of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Eur Respir J 42:18-27. 2013
    ..Blood sampling and spirometry were performed on subjects participating in a community-based annual health check in Takahata, Japan, from 2004 ..
  25. ncbi Bronchodilator responsiveness in patients with COPD
    D P Tashkin
    David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90024, USA
    Eur Respir J 31:742-50. 2008
    ..After wash-out of respiratory medications, patients received 80 mug ipratropium followed by 400 mug salbutamol. Spirometry was performed before and 90 min following ipratropium administration...
  26. ncbi Gender bias in the diagnosis of COPD
    K R Chapman
    Division of Respiratory Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Chest 119:1691-5. 2001
    ..There may also be underdiagnosis and misdiagnosis of COPD in both sexes because objective measures of lung function are underused...
  27. ncbi Screening for and early detection of chronic obstructive pulmonary disease
    Joan B Soriano
    CIMERA International Center for Advanced Respiratory Medicine, Recinte Hospital Joan March, Bunyola, Spain
    Lancet 374:721-32. 2009
    ..b>Spirometry is the most frequently used pulmonary function test and enables health professionals to make an objective ..
  28. ncbi Prevalence of COPD in five Colombian cities situated at low, medium, and high altitude (PREPOCOL study)
    Andrés Caballero
    Asociación Colombiana de Neumología y Cirugía de Tórax, Clinica Reina Sofia, Bogota, Colombia
    Chest 133:343-9. 2008
    ..The prevalence of COPD in Colombia is unknown. This study aimed to investigate COPD prevalence in five Colombian cities and measure the association between COPD and altitude...
  29. ncbi An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children
    Nicole Beydon
    Am J Respir Crit Care Med 175:1304-45. 2007
  30. ncbi Comparison of spirometric reference values
    Padmaja Subbarao
    Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Pediatr Pulmonol 37:515-22. 2004
    ..There are many proposed reference equations for pediatric spirometry. Recently, spirometric reference equations were proposed, using data from people aged 8-80 years living in the ..
  31. ncbi Components of the COPD Assessment Test (CAT) associated with a diagnosis of COPD in a random population sample
    Natya Raghavan
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, ON, Canada
    COPD 9:175-83. 2012
    ..health status impairment instrument, had additional utility in identifying patients at risk for COPD in whom spirometry testing is appropriate. This study was part of the Canadian Obstructive Lung Disease prevalence study...
  32. pmc The UK Quality and Outcomes Framework pay-for-performance scheme and spirometry: rewarding quality or just quantity? A cross-sectional study in Rotherham, UK
    Mark Strong
    School of Health and Related Research, University of Sheffield, Regent Court, Sheffield S14DA, UK
    BMC Health Serv Res 9:108. 2009
    Accurate spirometry is important in the management of COPD. The UK Quality and Outcomes Framework pay-for-performance scheme for general practitioners includes spirometry related indicators within its COPD domain...
  33. pmc Age- and size-related reference ranges: a case study of spirometry through childhood and adulthood
    T J Cole
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London WC1N 1EH, U K
    Stat Med 28:880-98. 2009
    ..The results show a strong multiplicative association between spirometry, height and age, with a large and nonlinear age effect across the age range...
  34. ncbi The prognostic importance of lung function in patients admitted with heart failure
    Kasper Karmark Iversen
    The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Eur J Heart Fail 12:685-91. 2010
    The purpose of the present study was to determine the prognostic importance for all-cause mortality of lung function variables obtained by spirometry in an unselected group of patients admitted with heart failure (HF).
  35. pmc Prevalence and underdiagnosis of chronic obstructive pulmonary disease among patients at risk in primary care
    Kylie Hill
    West Park Healthcare Centre, Toronto, Ont
    CMAJ 182:673-8. 2010
    ..We also evaluated the accuracy of prior diagnosis or nondiagnosis of COPD and identified associated clinical characteristics...
  36. ncbi Spirometry centile charts for young Caucasian children: the Asthma UK Collaborative Initiative
    Sanja Stanojevic
    Portex Unit, Respiratory Physiology and Medicine, UCL, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Am J Respir Crit Care Med 180:547-52. 2009
    Advances in spirometry measurement techniques have made it possible to obtain measurements in children as young as 3 years of age; however, in practice, application remains limited by the lack of appropriate reference data for young ..
  37. ncbi Respiratory symptoms and ventilatory function in workers exposed to portland cement dust
    Anne Kristin Møller Fell
    Occupational Health Service, Norcem AS, Brevik, Norway
    J Occup Environ Med 45:1008-14. 2003
    ..from the largest cement plant in Norway and 50 workers from a nearby control plant, born 1918 to 1938, performed spirometry and gave information on respiratory symptoms in 1998 and 1999...
  38. ncbi Screening for chronic obstructive pulmonary disease using spirometry: summary of the evidence for the U.S. Preventive Services Task Force
    Kenneth Lin
    Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA
    Ann Intern Med 148:535-43. 2008
    ..Fewer than half of the estimated 24 million Americans with airflow obstruction have received a COPD diagnosis, and diagnosis often occurs in advanced stages of the disease...
  39. ncbi Development of the asthma control test: a survey for assessing asthma control
    Robert A Nathan
    Asthma and allergy Associates and Research Center, Colorado Springs, USA
    J Allergy Clin Immunol 113:59-65. 2004
    ..In a busy clinic practice with limited time and resources, there is need for a simple method for assessing asthma control with or without lung function testing...
  40. pmc Reference ranges for spirometry across all ages: a new approach
    Sanja Stanojevic
    Portex Respiratory Physiology Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH UK
    Am J Respir Crit Care Med 177:253-60. 2008
    ..Health and Nutrition Examination Survey (NHANES III) reference is currently recommended for interpreting spirometry results, but it is limited by the lack of subjects younger than 8 years and does not continuously model ..
  41. ncbi Microalbuminuria, von Willebrand factor and fibrinogen levels as markers of the severity in COPD exacerbation
    Mehmet Polatli
    Department of Pulmonology, Adnan Menderes University Hospital, Aydin, Turkey
    J Thromb Thrombolysis 26:97-102. 2008
    ..We suggest that further studies are necessary to investigate the impact of antithrombotic treatment on microalbuminuria, plasma vWF and fibrinogen as markers of endothelial dysfunction coexisting COPD exacerbation...
  42. ncbi Forced spirometry reference values for Norwegian adults: the Bronchial Obstruction in Nord-Trøndelag Study
    A Langhammer
    , The Norwegian University of Science and Technology (NTNU, Verdal
    Eur Respir J 18:770-9. 2001
    The purpose of this study was to develop new prediction equations for flow/volume spirometry parameters in asymptomatic, never-smoking adults in Norway, and to assess any differences of these parameters when applying the new and most ..
  43. pmc Development and initial validation of a self-scored COPD Population Screener Questionnaire (COPD-PS)
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    COPD 5:85-95. 2008
    ..Of 697 patients surveyed, 295 patients met expert review criteria for spirometry performance; 38% of these (n = 113) had results indicating AO. Five items positively predicted AO (p < 0...
  44. pmc A randomized controlled trial to assess the efficacy of tiotropium in Canadian patients with chronic obstructive pulmonary disease
    Charles K N Chan
    University Health Network, Toronto General Hospital, Toronto, Canada
    Can Respir J 14:465-72. 2007
    ..Patients with chronic obstructive pulmonary disease (COPD) who smoke have a greater annual rate of decline in forced expiratory volume in 1 s (FEV(1)) than those patients who have stopped smoking...
  45. ncbi Burden and clinical features of chronic obstructive pulmonary disease (COPD)
    Romain A Pauwels
    Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
    Lancet 364:613-20. 2004
    ..If exposure is stopped, the disease may still progress due to the decline in lung function that normally occurs with aging, and some persistence of the inflammatory response...
  46. ncbi Early detection of COPD in a high-risk population using spirometric screening
    J Zielinski
    Department of Respiratory Medicine, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
    Chest 119:731-6. 2001
    To evaluate the efficacy of mass spirometry use for the detection of airflow obstruction in a high-risk population.
  47. ncbi Prevalence of COPD in Greece
    Nikolaos Tzanakis
    Department of Thoracic Medicine, University of Crete, Medical School, Greece
    Chest 125:892-900. 2004
    ..The prevalence of COPD in Greece is unknown. The aim of this study was to determine the prevalence and trends of COPD among adults in Greece...
  48. pmc Systemic inflammation in young adults is associated with abnormal lung function in middle age
    Ravi Kalhan
    Asthma Chronic Obstructive Pulmonary Disease Program, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e11431. 2010
    ..Whether systemic inflammation in healthy young adults is associated with future impairment in lung health is uncertain...
  49. ncbi The effect of incentive spirometry on postoperative pulmonary complications: a systematic review
    T J Overend
    School of Physical Therapy, University of Western Ontario, London, Ontario, Canada
    Chest 120:971-8. 2001
    To systematically review the evidence examining the use of incentive spirometry (IS) for the prevention of postoperative pulmonary complications (PPCs).
  50. ncbi Effect of late preterm birth on longitudinal lung spirometry in school age children and adolescents
    Sarah J Kotecha
    Department of Child Health, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Thorax 67:54-61. 2012
    ..Children born at 25-32 weeks gestation were also compared with children born at term...
  51. ncbi Using targeted spirometry to reduce non-diagnosed chronic obstructive pulmonary disease
    Lea Schirnhofer
    Department of Pulmonary Medicine, Paracelsus Medical University Hospital, Salzburg, Austria l schirnhofer salk at
    Respiration 81:476-82. 2011
    ..Chronic obstructive pulmonary disease (COPD) is increasing worldwide and thus its associated morbidity and mortality. However, COPD often goes undiagnosed...
  52. pmc Comparison of spirometry criteria for the diagnosis of COPD: results from the BOLD study
    W M Vollmer
    Kaiser Permanente, Center for Health Research, Portland, OR 97227 1110, USA
    Eur Respir J 34:588-97. 2009
    Published guidelines recommend spirometry to accurately diagnose chronic obstructive pulmonary disease (COPD). However, even spirometry-based COPD prevalence estimates can vary widely...
  53. ncbi [Spirometric reference values in 5 large Latin American cities for subjects aged 40 years or over]
    Rogelio Perez-Padilla
    Instituto Nacional de Enfermedades Respiratorias México DF México
    Arch Bronconeumol 42:317-25. 2006
    In clinical practice, spirometry is a extremely useful test that requires strict quality control, an appropriate strategy for interpretation, and reliable reference values...
  54. ncbi Under-report and underdiagnosis of chronic respiratory diseases in an African country
    P Martins
    Immunoallergy Department, Dona Estefania Hospital, Rua Jacinta Marto, Lisbon, Portugal
    Allergy 64:1061-7. 2009
    ..The second aim of the study was to identify factors related to airways obstruction and reported CRD in this population...
  55. pmc Vitamin D deficiency, smoking, and lung function in the Normative Aging Study
    Nancy E Lange
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 186:616-21. 2012
    ..Vitamin D has immunomodulatory and antiinflammatory effects that may be modified by cigarette smoke and may affect lung function...
  56. ncbi Spirometry utilization for COPD: how do we measure up?
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, USA
    Chest 132:403-9. 2007
    COPD is a significant cause of morbidity and mortality. Guidelines recommend the confirmation of a COPD diagnosis with spirometry. Limited evidence exists, however, documenting the frequency of spirometry use in clinical practice.
  57. ncbi Conditions associated with an abnormal nonspecific pattern of pulmonary function tests
    Robert E Hyatt
    Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Chest 135:419-24. 2009
    ..We term this a nonspecific pattern (NSP). We sought to identify medical conditions having this pattern and to explore mechanisms producing it...
  58. ncbi Impact of chronic obstructive pulmonary disease severity on surgical outcomes in patients undergoing non-emergent coronary artery bypass grafting
    Hesham Z Saleh
    Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK
    Eur J Cardiothorac Surg 42:108-13; discussion 113. 2012
    ..Our objective was to analyse the prognostic implication of COPD stages as defined by the Global Initiative for Chronic Obstructive Lung Disease...
  59. ncbi Exercise training on disease control and quality of life in asthmatic children
    Adriana Fanelli
    Physical Therapy Department, University City of Sao Paulo, and Hospital Darcy Vargas, Sao Paulo, Brazil
    Med Sci Sports Exerc 39:1474-80. 2007
    ..Aerobic training has been shown to be effective in improving cardiopulmonary fitness in asthmatic children. However, the actual impact of physical training on clinical indicators of disease control remains controversial...
  60. ncbi Tiotropium as a first maintenance drug in COPD: secondary analysis of the UPLIFT trial
    T Troosters
    Respiratory Division and Pulmonary Rehabilitation, UZ Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium
    Eur Respir J 36:65-73. 2010
    ..b>Spirometry, health-related quality of life (St George's Respiratory Questionnaire (SGRQ) score), exacerbations of COPD and ..
  61. ncbi Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters
    J R Swiston
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Eur Respir J 32:129-38. 2008
    ..The pulmonary response was assessed by questionnaires, spirometry and sputum induction...
  62. ncbi Airway narrowing measured by spirometry and impulse oscillometry following room temperature and cold temperature exercise
    Tina M Evans
    Marywood University, 2300 Adams Ave, Scranton, PA 18509, USA
    Chest 128:2412-9. 2005
    The efficacy of using impulse oscillometry (IOS) as an indirect measure of airflow obstruction compared to spirometry after exercise challenges in the evaluation of exercise-induced bronchoconstriction (EIB) has not been fully appreciated...
  63. ncbi Prediction equations for normal and low lung function from the Health Survey for England
    E Falaschetti
    Dept of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Eur Respir J 23:456-63. 2004
    ..It is, therefore, suggested that these newly developed prediction equations be used for the White English population in both epidemiological studies and clinical practice...
  64. ncbi Effects of obesity on perceptual and mechanical responses to bronchoconstriction in asthma
    Athavudh Deesomchok
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 181:125-33. 2010
    ..The influence of obesity on the perception of respiratory discomfort during acute bronchoconstriction in asthma is unknown...
  65. ncbi The variability of regional airflow obstruction within the lungs of patients with asthma: assessment with hyperpolarized helium-3 magnetic resonance imaging
    Eduard E de Lange
    Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 119:1072-8. 2007
    ..With hyperpolarized helium-3 magnetic resonance (H(3)HeMR) imaging, the airspaces are depicted and focal areas of airflow obstruction are shown as "ventilation defects."..
  66. ncbi Effect of obesity on airway inflammation: a cross-sectional analysis of body mass index and sputum cell counts
    D C Todd
    Department of Medicine, Firestone Institute for Respiratory Health, St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    Clin Exp Allergy 37:1049-54. 2007
    ..Airway inflammation using sputum cell counts has not been assessed in obese patients with airway diseases...
  67. ncbi Childhood factors that predict asthma in young adulthood
    B G Toelle
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    Eur Respir J 23:66-70. 2004
    ..At baseline, information about symptoms, spirometry, histamine challenge and skin-prick tests were collected...
  68. ncbi Exposure to thoracic dust, airway symptoms and lung function in cement production workers
    K C Nordby
    National Institute of Occupational Health, PO Box 8149 Dep, NO 0033 Oslo, Norway
    Eur Respir J 38:1278-86. 2011
    ..The results support the hypothesis that exposure to dust in cement production may lead to respiratory symptoms and airway obstruction...
  69. ncbi Bronchodilator responsiveness and onset of effect with budesonide/formoterol pMDI in COPD
    Bartolome R Celli
    Harvard University, Brigham and Women s Hospital, Pulmonary and Critical Care Medicine, Boston, MA 02115, USA
    Respir Med 105:1176-88. 2011
    ..We also evaluated the speed of onset of bronchodilation...
  70. ncbi Co-morbidity, body mass index and quality of life in COPD using the Clinical COPD Questionnaire
    Josefin Sundh
    Department of Respiratory Medicine, Orebro University Hospital, 701 85 Orebro, Sweden
    COPD 8:173-81. 2011
    ..The impact of different factors on the CCQ-score remains an understudied area. The aim of this study was to investigate the association of co-morbidity and body mass index with quality of life measured by CCQ...
  71. pmc Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers
    Cynthia Gordon
    Department of Genetic Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Am J Respir Crit Care Med 184:224-32. 2011
    ..Plasma levels of endothelial microparticles (EMPs), small vesicles released from activated or apoptotic endothelial cells, are elevated in vascular-related disorders...
  72. ncbi Reference values for lung function: past, present and future
    S Stanojevic
    Portex Respiratory Physiology Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Eur Respir J 36:12-9. 2010
    ..The overwhelming number of published reference equations, with at least 15 published for spirometry alone in the past 3 yrs, complicates the selection of an appropriate reference...
  73. ncbi Energy expenditure during daily activities as measured by two motion sensors in patients with COPD
    Vinicius Cavalheri
    Laboratório de Pesquisa em Fisioterapia Pulmonar LFIP, Departamento de Fisioterapia, Universidade Estadual de Londrina UEL, Rua Robert Koch, 60, Vila Operária, 86038 440 Londrina, Parana, Brazil
    Respir Med 105:922-9. 2011
    ..The aim of this study was to determine which daily activities are more demanding to patients with COPD and to compare the accuracy of EE estimation given by the pedometer Digiwalker SW701 (DW) and the multisensor SenseWear Armband (SAB)...
  74. pmc Lack of association of ischemic heart disease with COPD when taking into account classical cardiovascular risk factors
    Jose Luis Izquierdo
    Pulmonology Department, Hospital Universitario, Guadalajara, Spain
    Int J Chron Obstruct Pulmon Dis 5:387-94. 2010
    ..All patients underwent post-bronchodilator (PBD) spirometry, a standardized questionnaire, and blood analysis...
  75. pmc Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica
    John M Brehm
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:765-71. 2009
    ..Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood...
  76. ncbi Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Departments of Medicine, and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 158:1557-65. 1998
    ..During each of four visits conducted over an 8-wk period, spirometry and exercise testing were performed before and 1 h after receiving IB or P (randomized, double-blinded)...
  77. ncbi Impact of obesity on respiratory function
    Stephen W Littleton
    Pulmonary, Critical Care, and Sleep Medicine, Cook County Hospital and Rush University Medical Center, Chicago, Illinois, USA
    Respirology 17:43-9. 2012
    ..Lung volumes tend to be decreased, especially expiratory reserve volume. Spirometry, gas exchange and airway resistance all tend to be relatively well preserved when adjusted for lung volumes...
  78. ncbi Factors determining performance of bronchodilator reversibility tests in middle-aged and elderly
    Sverre Lehmann
    Department of Thoracic Medicine, Haukeland University Hospital, University of Bergen, Bergen N 5021, Norway
    Respir Med 98:1071-9. 2004
    ..Among the participants, 1.6% refused to inhale salbutamol, 2.5% failed the initial spirometry according to the ATS guidelines, and 1.3% failed the post-bronchodilator spirometry...
  79. ncbi The effect of air pollution on lung development from 10 to 18 years of age
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
    N Engl J Med 351:1057-67. 2004
    ..Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown...
  80. ncbi Prior TB, smoking, and airflow obstruction: a cross-sectional analysis of the Guangzhou Biobank Cohort Study
    Kin Bong Hubert Lam
    Institute of Occupational and Environmental Medicine, University of Birmingham, UK
    Chest 137:593-600. 2010
    ..We investigated the relationships between prior TB, smoking, and airflow obstruction in a Chinese population sample...
  81. pmc Atopic sensitization to common allergens without symptoms or signs of airway disorders does not increase exhaled nitric oxide
    Annamari Rouhos
    Division of Respiratory Diseases, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Clin Respir J 2:141-8. 2008
    ..It is, however, unclear whether sensitization to common allergens per se- as verified with positive skin prick tests--affects FENO in healthy individuals...
  82. ncbi A new method of negative expiratory pressure test analysis detecting upper airway flow limitation to reveal obstructive sleep apnea
    Giuseppe Insalaco
    Italian National Research Council, Institute of Biomedicine and Molecular Immunology A Monroy, Section of Respiratory Pathophysiology, Via Ugo La Malfa, 153 90146 Palermo, Italy
    Chest 128:2159-65. 2005
    ..NEP application during tidal expiration immediately determines a rise in expiratory flow (V) followed by a short-lasting V drop (deltaV), reflecting upper airway collapsibility...
  83. ncbi Quality of COPD care in hospital outpatient clinics in Denmark: The KOLIBRI study
    Peter Lange
    Department of Cardiology and Respiratory Medicine, Hvidovre Hospital, Denmark
    Respir Med 103:1657-62. 2009
    ....
  84. pmc Standardisation of lung function testing: helpful guidance from the ATS/ERS Task Force
    G Laszlo
    Thorax 61:744-6. 2006
  85. pmc Long-term safety of mometasone furoate/formoterol combination for treatment of patients with persistent asthma
    Jorge F Maspero
    Fundacion CIDEA, Allergy Respiratory Research, Buenos Aires, Argentina
    J Asthma 47:1106-15. 2010
    ..This study was conducted to evaluate the long-term safety of mometasone furoate/formoterol (MF/F) administered through metered-dose inhaler (MDI) in patients with persistent asthma previously on medium- to high-dose ICS...
  86. ncbi The effect of gender on the relationship between body fat distribution and lung function
    R I Harik-Khan
    Longitudinal Studies Section, Laboratory of Clinical Investigation, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224, USA
    J Clin Epidemiol 54:399-406. 2001
    ..383, P =.0005) compared to women (beta = -0.679, P =.02). Thus, body fat distribution has independent effects on lung function that are more prominent in men than women...
  87. ncbi A mixed methods study to compare models of spirometry delivery in primary care for patients at risk of COPD
    J A Walters
    Menzies Research Institute, PB 34, Clinical School, University of Tasmania, Hobart 7001, Australia
    Thorax 63:408-14. 2008
    To increase recognition of airflow obstruction in primary care, we compared two models of spirometry delivery in a target group at risk of chronic obstructive pulmonary disease (COPD).
  88. ncbi Primary care spirometry
    E Derom
    Dept of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Eur Respir J 31:197-203. 2008
    Primary care spirometry is a uniquely valuable tool in the evaluation of patients with respiratory symptoms, allowing the general practitioner to diagnose or exclude chronic obstructive pulmonary disease (COPD), sometimes to confirm ..
  89. pmc Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema
    Xiangyang Kong
    Research and Development, GlaxoSmithKline, 709 Swedeland Road, UW2230, King of Prussia, PA 19406, USA
    Am J Respir Crit Care Med 183:43-9. 2011
    ..Pulmonary emphysema is a major but variable component of COPD; familial data suggest that different components of COPD, such as emphysema, may be influenced by specific genetic factors...
  90. ncbi The clinical importance of dynamic lung hyperinflation in COPD
    Denis E O'Donnell
    Division of Respiratory and Critical Care Medicine, Departments of Medicine and Physiology, Queen s University, Kingston, Ontario, Canada
    COPD 3:219-32. 2006
    ..Finally, we will review current concepts of the mechanisms of symptom relief and improved exercise endurance following pharmacological lung volume reduction...
  91. pmc Alterations of the arginine metabolome in asthma
    Abigail Lara
    Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 178:673-81. 2008
    ..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation...
  92. ncbi Lung function impairment, COPD hospitalisations and subsequent mortality
    Judith Garcia-Aymerich
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Thorax 66:585-90. 2011
    ..A study was undertaken to examine the associations between lung function impairment and COPD hospitalisation, and COPD hospitalisation and mortality...
  93. ncbi Formoterol and tiotropium compared with tiotropium alone for treatment of COPD
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    COPD 6:17-25. 2009
    ..04) were seen at endpoint with combination FORM + TIO versus TIO monotherapy. Both treatments were well tolerated. This study demonstrated that concurrent treatment with FORM + TIO results in greater therapeutic benefits than TIO alone...
  94. ncbi Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Ontario, Canada
    Eur Respir J 23:832-40. 2004
    ..b>Spirometry, plethysmographic lung volumes, cycle exercise endurance and exertional dyspnoea intensity at 75% of each ..
  95. ncbi Spirometry can be done in family physicians' offices and alters clinical decisions in management of asthma and COPD
    Barbara P Yawn
    Olmsted Medical Center, Department of Research, 210 Ninth St SE, Rochester, MN 55904, USA
    Chest 132:1162-8. 2007
    b>Spirometry is recommended for diagnosis and management of obstructive lung disease...
  96. ncbi Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis
    P M Gustafsson
    Queens Silvia Children s Hospital and Department of Pediatrics, The Sahlgrenska Academy at Göteborg, Sweden
    Thorax 63:129-34. 2008
    ..index (LCI) from multiple-breath washout (MBW) is known to detect abnormal lung function more readily than spirometry in children and teenagers with CF, but its relationship to structural lung abnormalities is unknown...
  97. ncbi Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
    Dominick E Shaw
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK
    Chest 132:1871-5. 2007
    ..Chronic inflammation is assumed to be important, although there is limited and contradictory information about the relationship between airway inflammation and postbronchodilator FEV1...
  98. ncbi International Primary Care Respiratory Group (IPCRG) Guidelines: management of chronic obstructive pulmonary disease (COPD)
    David Bellamy
    James Fisher Medical Centre, 4, Tolpuddle Gardens, Bournemouth, Hants BH9 3LQ, UK
    Prim Care Respir J 15:48-57. 2006
    ....
  99. ncbi How often is diagnosis of COPD confirmed with spirometry?
    Mats Arne
    Primary Care Research Unit, County Council of Varmland, Universitetsgatan 3, SE 656 37, Karlstad, Sweden
    Respir Med 104:550-6. 2010
    ..Diagnosis is customarily confirmed with spirometry, but there are few studies on documented spirometry use in everyday clinical practice.
  100. ncbi Smoking cessation in chronic obstructive pulmonary disease
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1690, USA
    Respir Med 103:963-74. 2009
    ..is not known, as many individuals with the disease are left undiagnosed, despite the requirement of only simple spirometry testing for disease detection...

Research Grants76

  1. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..b>Spirometry, symptoms, sputum, blood, urine, exhaled breath and ultrasonography will be collected on all subjects pre- and ..
  2. Respiratory motor control and blood pressure regulation after spinal cord injury
    ALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2013
    ..We will evaluate pulmonary and cardiovascular function using spirometry, respiratory muscle strength, sympathetic skin response tests, and surface electromyography of respiratory ..
  3. A Pilot Study of Yoga for Breathing and Quality of Life of Lung Cancer Patients
    JUDITH MARIE FOULADBAKHSH; Fiscal Year: 2013
    ..study aims to (1) Identify the effects of a standardized, 12-week yoga intervention on breathing, specifically spirometry values, respiratory rate, reported dyspnea intensity and discomfort, oxygenation, and breathing awareness of ..
  4. For Hearing Component in the Hispanic Community Health Study (HCHS)
    Lisa Lavange; Fiscal Year: 2009
    ..Procedures for each enrolled subject include measurement of blood pressure, anthropometry, physical activity, spirometry, sleep studies, ECG, dental examination, hearing examination, and cognitive status measurement...
  5. Bisphenol A and Children's Growth & Development
    KIM G contact HARLEY; Fiscal Year: 2010
    ..of BPA in this cohort will lay the foundation for future examination of multiple other outcomes, such as asthma (including spirometry), immune function (Th1 and Th2 cytokines), and pubertal onset, in this rich and unique dataset.
  6. Perinatal Stress and programming of childhood wheeze and lung function
    Rosalind J Wright; Fiscal Year: 2013
    ..stress on risk for childhood wheezing phenotypes (early, late onset, persistent) and lung function outcomes [spirometry, airway inflammation (e.g., eNO), airway impedance in response to a social stressor] at age 6 years...
  7. Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)
    R Graham Barr; Fiscal Year: 2011
    ..among the two cohorts, which together provide a well-defined sampling frame of 4,617 participants with prior spirometry and CT measures...
  8. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..by an inability to assess directly the pulmonary circulation, lack of full-lung CT scans and post-bronchodilator spirometry, and mostly cross-sectional findings...
  9. 1st Tier Drugs+Theophylline in Pediatric Severe Asthma
    JERRY JOHN ZIMMERMAN; Fiscal Year: 2010
    ..more rapid normalization of pulse oximetry saturation, and respiratory rate, and accelerated improvement in spirometry variables associated with small airway obstruction...
  10. XeBox-E10 Gas Polarizer for Functional MRI of Pediatric Lung Disease
    SEAN BEDILION FAIN; Fiscal Year: 2013
    ..b>Spirometry, including infant pulmonary function tests (PFTs), has been shown to be inadequate for the assessment of mild ..
  11. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..symptoms, lung function, airway inflammation, and atopic markers using questionnaire, physical examination, spirometry, bronchial provocation, exhaled nitric oxide, sputum induction, skin prick test, and total IgE...
  12. NYU Lung Cancer Biomarker Center
    William N Rom; Fiscal Year: 2013
    ..Questionnaires, blood (100ml), spirometry, sputum, and CT-scans are obtained...
  13. Assessment of lung function in neonates and infants
    IULIAN CONSTANTIN RUSET; Fiscal Year: 2013
    ..Lung disease is the most common chronic disease of childhood, but methods for assessing lung disease such as spirometry cannot be performed by young children...
  14. The Race-Specific Prevalence of Atrial Fibrillation Measured by 48-Hour Holter
    LAURA L LOEHR; Fiscal Year: 2013
    ..risk factors and triggering factors of AF in African Americans from the electrocardiographic, echocardiographic, spirometry, and biomarker measures performed proximal to Holter monitoring...
  15. Xenon MRI assessment of response to cystic fibrosis therapies
    IULIAN CONSTANTIN RUSET; Fiscal Year: 2012
    ..Data will be incorporated into an imaging biomarker for CF and compared with other metrics such as spirometry and patient self-assessments...
  16. Metabolome and proteome profiles of emphysema and airway disease
    RUSSELL PAUL BOWLER; Fiscal Year: 2012
    ..COPD is usually studied as a single disease and traditionally diagnosed using spirometry;however, recent work suggests that COPD is more likely a heterogeneous syndrome with multiple smoking-related ..
  17. Health Effects of Adolescent Water Pipe Smoking with &without Cigarette Smoking
    Virginia Hill Rice; Fiscal Year: 2012
    ..The analyses will estimate the effects of smoking status on each of the spirometry outcomes (FEV1, FVC, FEV1/FVC, FEV25-75)...
  18. INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMA
    Frank D Gilliland; Fiscal Year: 2013
    ..These subjects will be phenotyped for AHR and lung function using standard spirometry protocols and assessed for clinical asthma status...
  19. Depression and functional outcomes in COPD: Impact of genetics and inflammation
    Huong Q Nguyen; Fiscal Year: 2013
    ..year 1 and year 2 will include: blood samples for genotyping (5-HTTLPR and STin2 VNTR) and cytokine assays, spirometry, assessment of depression, functional capacity (six minute walk test), performance (physical activity derived ..
  20. Effects of Long-Term Low Level Hydrogen Sulfide Exposure
    Michael N Bates; Fiscal Year: 2010
    ..the results of an examination of peripheral nerve function;(4) the results of lung function testing by spirometry;and (5) the results of ocular and vision testing including examination for cataract and color vision impairment...
  21. OPTIMIZE - CCC - Lead Application
    Bonnie W Ramsey; Fiscal Year: 2013
    ..in addition to other clinical efficacy outcomes such as changes in weight, growth, hospitalization rate, and spirometry. Previously unstudied characteristics of the respiratory microbiome predictive of poor microbiologic and/or ..
  22. Simultaneous Xe129 MRI of Regional Lung Ventilation and Gas Uptake in COPD
    John P Mugler; Fiscal Year: 2013
    ..third and final aim is to perform an exploratory study in 20 healthy control subjects, 10 smokers with normal spirometry and 30 subjects with COPD, ranging from GOLD stage 1 to 3, to characterize, as a function of disease severity, ..
  23. Enhancing Control of Pulmonary Disease Through Spirometry: Project COPD
    Min J Joo; Fiscal Year: 2013
    ..COPD can only be optimally treated when diagnosed accurately with a spirometry test...
  24. Heart Rate Variability Biofeedback: Its Role in Asthma Therapeutics
    Paul M Lehrer; Fiscal Year: 2013
    ..exploratory outcome measures evaluating the effect of HRV-BF on asthma symptoms, pulmonary function (through spirometry and forced oscillation pneumography), asthma quality of life, and psychological stress...
  25. Air pollution exposure and COPD in the Framingham Heart Study
    Mary B Rice; Fiscal Year: 2013
    ..Few studies have been able to measure spirometry repeatedly and examine multiple exposures, including constituents of fine particulate matter, to understand ..
  26. AMSA: ALXR/FBR Mediated Signaling in Severe Asthma
    Bruce D Levy; Fiscal Year: 2013
    ..The clinical course of these subjects (particularly exacerbations and spirometry) will be monitored over 3 years followed by a repeat course of parenteral corticosteroids...
  27. Portable Device to Diagnose/Monitor Pediatric Exercise-Induced Vocal Fold Motion
    JAFAR VOSSOUGHI; Fiscal Year: 2010
    ..Other alternatives have their respective disadvantages. For instance, the spirometry has low sensitivity (23%) and dependent on the child's effort to obtain accurate measurement;the ..
  28. OPTIMIZE - DCC
    Nicole Mayer Hamblett; Fiscal Year: 2013
    ..in addition to other clinical efficacy outcomes such as changes in weight, growth, hospitalization rate, and spirometry. Previously unstudied characteristics of the respiratory microbiome predictive of poor microbiologic and/or ..
  29. Risk Factors Accounting for Neighborhood Differences in Asthma Prevalence
    Matthew S Perzanowski; Fiscal Year: 2010
    ..More severe asthma (as classified by symptoms and spirometry), 2b.) higher levels of exhaled nitric oxide, a measure of airway inflammation. Aim 3...
  30. Long-Term Lung Health After Exposure to Chlorine Gas
    ERIK ROBERT SVENDSEN; Fiscal Year: 2013
    ..We have a cohort of 8,234 millworkers with at least 3 years of pre-event spirometry data...
  31. The Lung Clearance Index as a Marker of Early Lung Disease in Preschool Children
    Felix Ratjen; Fiscal Year: 2013
    ..Traditional measures of lung function, such as spirometry, are difficult to measure in young children and are not able to detect abnormalities in this age group...
  32. Airway Inspector: a chest imaging biomarker software platform for COPD
    Raul San Jose Estepar; Fiscal Year: 2013
    ..Although spirometry is critical for diagnosis of COPD, FEV1 may be of limited value in a classification scheme designed to ..
  33. Computerized Classification of COPD and Contributing Components
    Joseph K Leader; Fiscal Year: 2010
    ..Each subject will undergo biennial spirometry and CT examinations...
  34. Noninvasive Assessment of Neuromuscular Disease using Electrical Impedance
    Jeremy M Shefner; Fiscal Year: 2013
    ..standard measurements of disease progression including handheld dynamometry, ALS Functional Rating Scale, and spirometry. The best array design for assessing disease progression will be identified and compared to conventional markers ..
  35. UNCLASSIFIED SPIROMETRIC ABNORMALITIES: RADIOLOGY, EPIDEMIOLOGY, AND GENETICS
    Edwin K Silverman; Fiscal Year: 2010
    ..We hypothesize that a subset of unclassified spirometry subjects have COPD which can be determined based on radiologic and genetic studies...
  36. Ancillary 129Xe Studies for COPDGene
    Samuel Patz; Fiscal Year: 2013
    ..COPDGene is obtaining spirometry, CT and symptomatic questionnaire data on 10,500 smokers with a range of lung function...
  37. Improving Asthma Outcomes Through Spirometry Distance Learning
    Rita Mangione-Smith; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Spirometry is a recommended component of asthma diagnosis and treatment in the primary care setting, yet few providers report its routine use for children with asthma...
  38. EIT: a non-radiating functional imaging method for cystic fibrosis
    JENNIFER LYNN MUELLER; Fiscal Year: 2013
    ..I. Data will be collected during spirometry on CF patients clinically indicated for CT scans and on subjects with healthy lungs, and the sensitivity and ..
  39. Is Sputum Eosinophilia A Prognosis Factor for Occupational Asthma? A proof of Con
    Catherine Lemiere; Fiscal Year: 2011
    ..These subjects will be invited to attend a follow-up visit. Spirometry, methacholine challenge, sputum induction and measure of exhaled nitric oxide (eNO) will be performed...
  40. Design and Testing of tools to Identify individuals at high risk for COPD 73
    Fernando J Martinez; Fiscal Year: 2013
    ..Testing that might support the diagnosis of COPD is not routinely performed. Although spirometry is not recommended for detecting all people at risk for early COPD, screening those more likely to have disease ..
  41. Longitudinal Phenomics and Genetics of Severe Asthma
    Deborah A Meyers; Fiscal Year: 2013
    ..Subjects will be reassessed yearly (spirometry and reversibility, eNO, sputum induction and questionnaires) with additional telephone contact every six months...
  42. Precision Ventilation -Anesthesia Delivery System for Larger-Animal PET/CT Imagin
    JONATHAN PAUL JAMES CARNEY; Fiscal Year: 2013
    ..The lung spirometry feature on the Aisys system can be used to evaluate global pulmonary function at the time of scanning to ..
  43. Exhaled Nitric Oxide: Mechanisms and Limitations
    STEVEN CARL GEORGE; Fiscal Year: 2010
    ..Traditional techniques, such as spirometry, are aimed at examining physical features of the lungs, such as airway caliber...
  44. A Web-Based Module for Asthma Management in Primary Care
    PAUL JOSEPH contact HELMUTH; Fiscal Year: 2010
    ..and 2) to establish the effect size of the intervention in improving objective measures of lung function (office spirometry), with the ultimate goal of powering a large-scale, randomized controlled trial of the product...
  45. Morbidity and Mortality in Marysville, Ohio due to Exposure to Asbestos Contamina
    James Lockey; Fiscal Year: 2010
    ..Also, previous health endpoints were evaluated with chest X-rays and spirometry. The proposed study will use HRCTs and complete lung function testing to provide more precise and sensitive ..
  46. Cardiovascular Health Study - Transition Phase - Renewal
    Richard A Kronmal; Fiscal Year: 2009
    ..disease such as carotid ultrasound, cranial magnetic resonance imaging, echocardiography, ankle-brachial index, spirometry, and retinal photography, as well as more traditional questionnaire, physiologic, and biochemical measures of ..
  47. Cardiovascular Health Study - Transition Phase - Renewal
    Richard A Kronmal; Fiscal Year: 2011
    ..disease such as carotid ultrasound, cranial magnetic resonance imaging, echocardiography, ankle-brachial index, spirometry, and retinal photography, as well as more traditional questionnaire, physiologic, and biochemical measures of ..
  48. Cardiovascular Health Study - Transition Phase - Renewal
    Richard A Kronmal; Fiscal Year: 2010
    ..disease such as carotid ultrasound, cranial magnetic resonance imaging, echocardiography, ankle-brachial index, spirometry, and retinal photography, as well as more traditional questionnaire, physiologic, and biochemical measures of ..
  49. Early Identification of World Trade Center Conditions in Adolescents
    Leonardo Trasande; Fiscal Year: 2013
    ..regularly provide clinical care to children who lived/attended school near the WTC site identified decrements in spirometry associated with dust cloud exposure, and a remarkably high frequency of cardiometabolic risk factors...
  50. Fresno Asthmatic Children's Environment Study (FACES)
    Ira B Tager; Fiscal Year: 2010
    ..The 14-day panel studies include twice- daily spirometry and symptom evaluation...
  51. A Pilot Stress Management Intervention for High Risk Children with Asthma
    Anna L Marsland; Fiscal Year: 2013
    ..for intervention-related decreases in perceived stress and improvements in lung function, as measured by spirometry. The primary objective of the proposed research is to conduct a critical randomized controlled pilot evaluation ..
  52. Mechansims and Clinical Importance of Hyperkyphosis:The Framingham Study
    ELIZABETH SAMELSON; Fiscal Year: 2013
    ..we will determine the association between progression of kyphosis and declines in lung function (assessed by spirometry) and physical function (timed walk, Nagi and Rosow-Breslau scales) in women and men...
  53. CAMP Continuation Study/Phase 3
    Robert Strunk; Fiscal Year: 2010
    ..Data collection procedures for spirometry and other procedures will be identical to those used in previous phases of the CAMP study...
  54. CAMP Continuation Study/Phase 3
    Hartmut Grasemann; Fiscal Year: 2010
    ..Data collection procedures for spirometry and other procedures will be identical to those used in previous phases of the CAMP study...
  55. COMMUNITY BASED STUDY ON OCCUPATIONAL ASTHMA, ECRHS-OA
    Manolis Kogevinas; Fiscal Year: 2001
    ..Subjects will be asked to perform a forced spirometry, methacholine challenge and to provide blood samples for IgE testing...
  56. Self-Monitoring of Symptoms and Spirometry to Improve Outcomes in CF
    NATALIE ELLIOTT WEST; Fiscal Year: 2010
    ..AIM 2: To examine the effects of home spirometry and symptoms monitoring on the rate of annual decline in FEV1...
  57. HE3 MR Diffusion & Low Dose CT Quantitation of Emphysema
    David Gierada; Fiscal Year: 2005
    ..Though spirometry is used to diagnose COPD, it is a relatively inaccurate means of assessing for emphysema...
  58. Testing a Measurement Model of Acute Dyspnea
    Mark Parshall; Fiscal Year: 2005
    ..the degree to which changes in dyspnea distress, intensity, or sensory quality are associated with changes in spirometry or BNP values over the study interval. The measurement model comprises three to five sensory quality factors...
  59. INNER CITY COCKROACH ALLERGEN REDUCTION TRIAL
    Peyton Eggleston; Fiscal Year: 2002
    ..The child will undergo allergy skin tests, serum for IgE antibody to cockroach, spirometry and methacholine inhalation challenge...
  60. OCCUPATIONAL ASTHMA ASOCIATED WITH SEAFOOD PROCESSING
    Thomas Robins; Fiscal Year: 2001
    ..to processing of rock lobster and saltwater bony fish through subject interviews, physical examination (skin), spirometry and methacholine challenge tests, skin prick tests (for common aeroallergens and specific seafood allergens) and ..
  61. PHASE 2 & 3 TRIALS OF HIGH-DOSE ORAL N-ACETYLCYSTEINE IN CYSTIC FIBROSIS
    Carol Conrad; Fiscal Year: 2007
    ..and on four secondary outcome measurements, namely functional expiratory volume in 1 second (measured by spirometry), intracellular GSH in blood neutrophils (measured by flow cytometry), sputum neutrophil elastase activity (..
  62. ALTITUDE ADAPTATION IN CHRONIC LUNG DISEASE
    William Graham; Fiscal Year: 1980
    ..b>Spirometry will be performed twice daily on the mountain...
  63. ENVIRONMENTAL/OCCUPATIONAL MED ACADEMIC AWARD, NIEHS
    Kenneth Rosenman; Fiscal Year: 2000
    ..This would include training residents in audiometry and spirometry, training on how to evaluate impairment as well as building diagnostic and management skills...
  64. Pulsus Paradoxus Monitor
    Gregory Jay; Fiscal Year: 2005
    ..Unlike peak flow rate and spirometry, PP measurement is non-effort dependent and would theoretically result in better assessment of asthma severity...
  65. Spirometry to Motivate Quit-Smoking Attempts: Message Development and Testing
    David Kaminsky; Fiscal Year: 2009
    ..One of these risks is decreased lung function as measured by spirometry. However, the evidence that spirometry enhances smoking cessation is limited...
  66. CHICAGO INNER CITY ASTHMA STUDY
    Richard Evans; Fiscal Year: 2001
    ..Patients will receive skin testing and spirometry, and they/caretakers will complete various written assessments of asthma risk and asthma knowledge...
  67. Aerosolized hyaluronic acid as a treatment for COPD
    Gerard Turino; Fiscal Year: 2006
    ..Two additional endpoints, spirometry and lung volumes, will be included to look for therapeutic benefits that might be possible even over the short ..
  68. UTEP-UNM HSC ARCH PROGRAM ON BORDER ASTHMA
    NICHOLAS PINGITORE; Fiscal Year: 2009
    ..by Impulse Oscillometry (IOS) methods in a clinical setting will be compared to lung function measured with spirometry methods promotoras in the local communities...
  69. Perinatal Risk of Asthma in Infants of Asthmatic Mothers
    Michael Bracken; Fiscal Year: 2007
    ..obtained prospectively and include obstetrical and delivery history, history of maternal asthma (measured by spirometry, symptoms, medication) and infections, prenatal medication history, maternal smoking history, job exposures and ..