maximal expiratory flow volume curves

Summary

Summary: Curves depicting MAXIMAL EXPIRATORY FLOW RATE, in liters/second, versus lung inflation, in liters or percentage of lung capacity, during a FORCED VITAL CAPACITY determination. Common abbreviation is MEFV.

Top Publications

  1. ncbi Area under the maximum expiratory flow-volume curve--a sensitive parameter in the evaluation of airway patency
    Alois Zapletal
    Department of Pediatrics, University Hospital Motol, Prague, Czech Republic
    Respiration 75:40-7. 2008
  2. ncbi [Respiratory function tests in children aged 3-6 years with cystic fibrosis: indications and execution]
    M N Lebras-Isabet
    Service de Gastroenterologie, Mucoviscidose et Nutrition Pédiatriques Pr Cezard, CRCM, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris
    Rev Pneumol Clin 63:313-8. 2007
  3. ncbi [Bacterial pathogens in sputum and degree of bronchial obstruction in patients with acute exacerbation of chronic obstructive pulmonary disease]
    Marco Biagini
    Unità Operativa Pneumologia, Ospedale S Donato, USL 8, Arezzo
    Recenti Prog Med 93:470-3. 2002
  4. ncbi Effect of body posture on dynamic lung functions in young non-obese Indian subjects
    A Talwar
    Department of Physiology, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak 124001
    Indian J Med Sci 56:607-12. 2002
  5. ncbi A model-based method for flow limitation analysis in the heterogeneous human lung
    Adam G Polak
    Chair of Electronic and Photonic Metrology, Wrocław University of Technology, Wrocław, Poland
    Comput Methods Programs Biomed 89:123-31. 2008
  6. ncbi [Usefulness of ventilation tests in the diagnosis and evaluation of treatment results in select laryngeal diseases]
    Maciej Misiołek
    Katedra i Oddział Kliniczny Laryngologii w Zabrzu Sl AM w Katowicach
    Otolaryngol Pol 59:565-9. 2005
  7. ncbi The maximum expiratory flow-volume loop in natives of Ladakh and acclimatized lowlanders
    Chandrashekhar V Apte
    MIMER Medical College, Talegaon Dabhade, District Pune, India
    High Alt Med Biol 6:209-14. 2005
  8. ncbi [Evaluation of a new method for detection of obstructive disease in children asthma: the negative expiratory pressure (NEP)]
    P Forey
    Service de Pediatrie, CHU Morvan, 29609 Brest Cedex, France
    Arch Pediatr 12:1338-43. 2005
  9. ncbi [Pulmonary function tests in patients with rheumatoid arthritis]
    Yoshiaki Tanaka
    Department of Allergology and Immunological Diseases, Tokyo Metropolitan Komagome Hospital
    Nihon Rinsho 63:371-4. 2005
  10. ncbi Randomized controlled trial of salbutamol aerosol therapy via metered dose inhaler-spacer vs. jet nebulizer in young children with wheezing
    J Deerojanawong
    Division of Pediatric Pulmonology and Critical Care, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Pediatr Pulmonol 39:466-72. 2005

Research Grants

Scientific Experts

Detail Information

Publications134 found, 100 shown here

  1. ncbi Area under the maximum expiratory flow-volume curve--a sensitive parameter in the evaluation of airway patency
    Alois Zapletal
    Department of Pediatrics, University Hospital Motol, Prague, Czech Republic
    Respiration 75:40-7. 2008
    ..The most frequently used parameters for assessing bronchoconstriction and bronchodilation are forced expiratory volume in 1 s (FEV(1)) and peak expiratory flow (PEF)...
  2. ncbi [Respiratory function tests in children aged 3-6 years with cystic fibrosis: indications and execution]
    M N Lebras-Isabet
    Service de Gastroenterologie, Mucoviscidose et Nutrition Pédiatriques Pr Cezard, CRCM, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris
    Rev Pneumol Clin 63:313-8. 2007
  3. ncbi [Bacterial pathogens in sputum and degree of bronchial obstruction in patients with acute exacerbation of chronic obstructive pulmonary disease]
    Marco Biagini
    Unità Operativa Pneumologia, Ospedale S Donato, USL 8, Arezzo
    Recenti Prog Med 93:470-3. 2002
    ..The association between the lowest values of FEV1 in stable clinical conditions and the isolation of BN in sputum during AECB could be useful in the choice of the empiric antibiotic therapy during exacerbations...
  4. ncbi Effect of body posture on dynamic lung functions in young non-obese Indian subjects
    A Talwar
    Department of Physiology, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak 124001
    Indian J Med Sci 56:607-12. 2002
    ..Thus, measurement of FVL in supine posture may be used to detect UAO as it may be missed if spirometry is performed in sitting posture...
  5. ncbi A model-based method for flow limitation analysis in the heterogeneous human lung
    Adam G Polak
    Chair of Electronic and Photonic Metrology, Wrocław University of Technology, Wrocław, Poland
    Comput Methods Programs Biomed 89:123-31. 2008
    ..Turbulent dissipation, however, may play a significant role as a supporting factor in transition between wave-speed and viscous flow limitation...
  6. ncbi [Usefulness of ventilation tests in the diagnosis and evaluation of treatment results in select laryngeal diseases]
    Maciej Misiołek
    Katedra i Oddział Kliniczny Laryngologii w Zabrzu Sl AM w Katowicach
    Otolaryngol Pol 59:565-9. 2005
    ..In conclusion the great role of ventilation tests was emphasized, especially in diagnosis of the narrowing on the larynx and trachea level and also in evaluation of the results after surgical procedures on upper airways...
  7. ncbi The maximum expiratory flow-volume loop in natives of Ladakh and acclimatized lowlanders
    Chandrashekhar V Apte
    MIMER Medical College, Talegaon Dabhade, District Pune, India
    High Alt Med Biol 6:209-14. 2005
    ..1.06 (0.35) L/s, p = 0.0001]. The exact mechanisms allowing the higher flow rates at low lung volumes remain to be elucidated, but it is possible that these findings may indicate an inherited adaptive response in the Ladakhi highlander...
  8. ncbi [Evaluation of a new method for detection of obstructive disease in children asthma: the negative expiratory pressure (NEP)]
    P Forey
    Service de Pediatrie, CHU Morvan, 29609 Brest Cedex, France
    Arch Pediatr 12:1338-43. 2005
    ..To take in charge of an asthmatic child it is necessary to evaluate the lung function...
  9. ncbi [Pulmonary function tests in patients with rheumatoid arthritis]
    Yoshiaki Tanaka
    Department of Allergology and Immunological Diseases, Tokyo Metropolitan Komagome Hospital
    Nihon Rinsho 63:371-4. 2005
  10. ncbi Randomized controlled trial of salbutamol aerosol therapy via metered dose inhaler-spacer vs. jet nebulizer in young children with wheezing
    J Deerojanawong
    Division of Pediatric Pulmonology and Critical Care, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Pediatr Pulmonol 39:466-72. 2005
    ..However, salbutamol aerosol therapy via jet nebulizer significantly increased the heart rate when compared to the MDI-spacer...
  11. ncbi [Comparison of pulmonary function of asthma children determined with impulse oscillometry and maximal expiratory flow-volume curve]
    Li Xiang
    Zhonghua Er Ke Za Zhi 41:52-3. 2003
  12. ncbi Should flow-volume loop be monitored in sleep apnea patients treated with continuous positive airway pressure?
    Marcel Bonay
    Service de Physiologie Explorations Fonctionnelles, Hôpital Louis Mourier AP HP, 178, rue des Renouillers, Colombes 92700, France
    Respir Med 97:830-4. 2003
    ..Moreover, bronchial hyperresponsiveness occurred in five of 22 patients of this group. These results suggest that tolerance of nCPAP should be handled by long-term follow-up of flow-volume loops...
  13. ncbi [Evaluation of respiratory function in the elderly]
    E Orvoen-Frija
    Service de physiologie explorations fonctionnelles respiratoires, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris VI, France
    Rev Mal Respir 24:789-90. 2007
  14. ncbi [Prediction of exercise capacity in chronic obstructive pulmonary disease patients on the basis of maximum expiratory flow-volume curve]
    Marzena Trzaska-Sobczak
    Katedra i Klinika Pneumonologii, Slaska Akademia Medyczna w Katowicach, Katowice, Poland
    Pneumonol Alergol Pol 75:213-8. 2007
    ....
  15. ncbi Correlation of spirometry and symptom scores in childhood asthma and the usefulness of curvature assessment in expiratory flow-volume curves
    Johannes H Wildhaber
    Institute of Fluid Dynamics, ML H 35, Eidgenössische Technische Hochschule ETH, The Swiss Federal Institute of Technology Zurich, Sonneggstrasse 3, 8092 Zurich, Switzerland
    Respir Care 52:1744-52. 2007
    ..Therefore, some clinicians subjectively assess the presence of curvature in the maximum expiratory flow-volume (MEFV) curves obtained from spirometry, where concave patterns are observable despite normal FEV(1) values...
  16. ncbi Respiratory findings in tobacco workers
    Jadranka Mustajbegovic
    Andrija Stampar School of Public Health, Zagreb, Croatia
    Chest 123:1740-8. 2003
    ..To screen for respiratory symptoms and lung function impairment in workers occupationally exposed to tobacco dust in a tobacco-processing plant...
  17. ncbi Maximal expiratory flow at FRC (V'maxFRC): Methods of selection and differences in reported values
    Anastassios C Koumbourlis
    Pediatric Pulmonary Division, Columbia Presbyterian Medical Center, New York, New York, USA
    Pediatr Pulmonol 37:318-23. 2004
    ....
  18. ncbi Accounting for flow dependence of respiratory resistance during exercise
    Claire de Bisschop
    Laboratoire d Analyse de la Performance Motrice Humaine, Faculte des Sciences du Sport, UPRES EA 2253, 4 Allée Jean Monnet, 86000 Poitiers, France
    Respir Physiol Neurobiol 136:65-76. 2003
    ..The relative decrease in Rrs with exercise suggests bronchodilation. The bronchodilating effect disappeared promptly when exercise was stopped suggesting that it may have been related to a reflex mechanism...
  19. ncbi [What is the status of oral corticotherapy in asthma?]
    Pascal Chanez
    Service de Pneumologie, Hopital Arnaud de Villeneuve, 34295 Montpellier Cedex 5
    Rev Prat 55:1340-1. 2005
  20. ncbi Respiratory mechanics and maximal expiratory flow in the anesthetized mouse
    Y L Lai
    Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Appl Physiol (1985) 88:939-43. 2000
    ....
  21. ncbi Tidal expiratory flow limitation and chronic dyspnoea in patients with cystic fibrosis
    D Goetghebeur
    Unité d Explorations Fonctionelles Respiratoires, Service de Pneumologie, Universite de Bretagne Occidentale, Centre Hospitalier Universitaire, Brest, France
    Eur Respir J 19:492-8. 2002
    ..The conventional method for assessing expiratory flow limitation is not reliable and bronchodilator administration has little effect on expiratory flow limitation...
  22. ncbi Mid-term survival after abdominal aortic aneurysm surgery predicted by cardiopulmonary exercise testing
    J Carlisle
    Department of Anaesthesia and Critical Care Medicine, Torbay Hospital, Torquay TQ2 7AA, UK
    Br J Surg 94:966-9. 2007
    ..This study aimed to determine whether preoperative CPX testing predicted postoperative survival following elective abdominal aortic aneurysm (AAA) repair...
  23. ncbi Supramaximal flow in asthmatic patients
    H Sala
    Posadas Hospital, El Palomar, Buenos Aires, Argentina
    Eur Respir J 19:1003-7. 2002
    ..The results of this study suggest that in asthmatic patients participation of "pendelluft" in SF increases as airflow limitation increases...
  24. ncbi [A case of relapsing polychondritis monitored by repeated measurements of flow-volume curve]
    Takashi Niju
    Department of Respiratory Medicine, Nishinomiya Municipal Central Hospital
    Nihon Kokyuki Gakkai Zasshi 46:220-5. 2008
    ..In this case, monitoring of flow-volume curve was useful for the evaluation of airway complication in relapsing polychondritis...
  25. ncbi Reference values of pulmonary diffusing capacity during exercise by a rebreathing technique
    C C Hsia
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas 75235 9034, USA
    Am J Respir Crit Care Med 152:658-65. 1995
    ..We conclude that QC is the most important determinant of the recruitment of diffusing capacity. From rest to near-maximal exercise, DLCO, DMCO, and VC increase linearly with respect to QC without evidence of reaching a plateau...
  26. ncbi [Changes of tangent time constant in the transformation of F-V curve configuration in COPD and cor pulmonale patients and clinical implications]
    G Huang
    Department of Physiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China
    Hua Xi Yi Ke Da Xue Xue Bao 32:101-3. 2001
    ..The convenience and correctness of the method may be available for clinical application...
  27. ncbi Passive expiratory flow-volume curve is not an accurate method to measure the respiratory time constant in rabbits
    R Vialet
    Department of Anesthesia and Critical Care, Centre Hospitalier Universitaire, , Marseille, France
    Acta Anaesthesiol Scand 43:1017-20. 1999
    ..CONCLUSIONS: The end-inspiratory occlusion technique leads to a systemic bias in measurements of respiratory time constant, especially when the resistance of the respiratory system is elevated...
  28. ncbi Forced expiratory manoeuvres in children: do they meet ATS and ERS criteria for spirometry?
    H G Arets
    Dept of Paediatric Pulmonology, University Medical Centre Utrecht, The Netherlands
    Eur Respir J 18:655-60. 2001
    ..However, most of their MEFV curves are useful for interpretation. Based on the performance of these children, a re-evaluation of criteria for maximal expiratory flow/volume measurements in children is proposed...
  29. pmc An epidemiological study of the health of Sri Lankan tea plantation workers associated with long term exposure to paraquat
    N Senanayake
    Faculty of Medicine, University of Peradeniya, Sri Lanka
    Br J Ind Med 50:257-63. 1993
    ..The results of this study confirmed that long term spraying of paraquat, at the concentrations used, produced no adverse health effects, in particular no lung damage, attributable to the occupational use of the herbicide...
  30. ncbi [The utility of the flow-volume curve in detecting fixed extrathoracic stenoses in patients with chronic obstructive pulmonary disease]
    J L Izquierdo Alonso
    , Hospital Universitario de Guadalajara
    Arch Bronconeumol 32:216-21. 1996
    ..We conclude that the flow-volume curve may not detect the existence of upper airways obstruction in COPD, and that in the most severely affected patients alternative diagnostic methods should therefore be considered...
  31. ncbi Respiratory symptoms and pulmonary function in flour processing workers in the baking industry
    M H Shamssain
    Department of Physiology, Faculty of Medicine and Health Sciences, University of Transkei, Unitra, Umtata, Southern Africa
    Am J Ind Med 27:359-65. 1995
    ..abstract truncated at 250 words)..
  32. ncbi The best peak expiratory flow is flow-limited and effort-independent in normal subjects
    Claudio Tantucci
    Clinica di Medicina Interna, Universita di Brescia, Brescia, Italy
    Am J Respir Crit Care Med 165:1304-8. 2002
    ....
  33. ncbi Dependence of maximal flow-volume curves on time course of preceding inspiration in patients with chronic obstruction pulmonary disease
    E Prandi
    Istituto di Fisiologia Umana I, , Italy
    Am J Respir Crit Care Med 150:1581-6. 1994
    ..Other factors (e.g., time constant inequality) might also be involved. In any case, the results imply that the inspiratory maneuver prior to FVC must be standardized...
  34. ncbi New model-based indices for maximum expiratory flow-volume curve in patients with chronic obstructive pulmonary disease
    O Barnea
    Biomedical Engineering Department, Tel Aviv University, Israel
    Comput Biol Med 26:123-31. 1996
    ..Further studies in larger groups of patients are required to better define the true predictive value of the new indices described for the diagnosis of COPD...
  35. ncbi Estimation of ventilatory capacity during submaximal exercise
    T G Babb
    Department of Medicine, Baylor College of Medicine, Houston, Texas
    J Appl Physiol 74:2016-22. 1993
    ..These data suggest that this technique may be useful in estimating ventilatory capacity, which could then be used to evaluate ventilatory reserve during exercise...
  36. ncbi Small airways function in patients with inflammatory bowel disease
    N Tzanakis
    Department of Thoracic Medicine, Medical School University of Crete, Greece
    Am J Respir Crit Care Med 157:382-6. 1998
    ..05). This may indicate that lung parenchyma is also involved in active IBD. Our results suggest that the function of the small airways and diffusion capacity of the lungs are affected in patients with IBD...
  37. ncbi [Comparative study of ventilatory functions of smokers with MTTp and F-V curve configuration]
    G Huang
    Department of Physiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041
    Hua Xi Yi Ke Da Xue Xue Bao 30:50-3. 1999
    ..The value of MTTp calculated with "convenient calculation" is accurate and easy-to-do so the method is appropriate for clinical application...
  38. ncbi Changes in pulmonary function and cross-sectional area of trachea and bronchi in asthmatics following inhalation of procaterol hydrochloride and ipratropium bromide
    V Hoffstein
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    Am J Respir Crit Care Med 149:81-5. 1994
    ..abstract truncated at 250 words)..
  39. ncbi [The control of respiration in pulmonary fibrosis. The effect of O2 and CO2]
    S Launois
    , , Paris
    Rev Mal Respir 8:67-73. 1991
    ..This normal ventilation results from hyperactivity of the respiratory centre, as in the hyperventilation induced by carbon dioxide when at rest...
  40. ncbi Effect of age on changes in flow rates and airway conductance after a deep breath
    R B Berry
    Department of Medicine, Veterans Administration Medical Center, Long Beach 90822
    J Appl Physiol 68:635-43. 1990
    ....
  41. ncbi The dose-response slope: a useful method for expressing the results of methacholine provocation tests in healthy subjects?
    O P Seppälä
    Department of Clinical Pharmacology, University of Turku, Finland
    Respir Med 85:365-71. 1991
    ..However, DRSFEV1 had clearly wider limits of agreement and CIsm than DRSAEFV. Also, with DRSFEV1 the observations of the two days differed significantly more from each other than with DRSAEFV (P less than 0.05)...
  42. ncbi Tidal breath flow-volume curves in obstructive sleep apnea
    R A Kayaleh
    Pulmonary and Critical Care Medicine, University of California, Irvine, Orange 92668
    Am Rev Respir Dis 145:1372-7. 1992
    ..We believe this positional change in TBFVC reflects upper airway functional narrowing induced by assumption of supine position and decreasing airflow rates...
  43. ncbi [The bronchodilator effect of aerosol beta-2-mimetic and anticholinergic agents in patients with chronic bronchitis]
    R Vestri
    Service de Pneumologie Allergologie, CHU Nord, Marseille
    Rev Mal Respir 7:59-63. 1990
    ..Some patients responded to bronchodilators, others uniquely to one of the two products and finally some to neither. Without reversibility tests it is not possible to predict the response to atropine from the response to beta-2-mimetics...
  44. pmc Peak expiratory flow at altitude
    P S Thomas
    Clinical Research Centre, Northwick Park Hospital, Harrow
    Thorax 45:620-2. 1990
    ..Measurements of PEF made at altitude with the mini Wright meter should be corrected by adding 6.6% per 100 mm Hg drop in barometric pressure...
  45. ncbi Changes in airflow obstruction and oxygen saturation in response to exercise and bronchodilators in cystic fibrosis
    P I Macfarlane
    Respiratory Unit, Royal Liverpool Children s Hospital Alder Hey, England
    Pediatr Pulmonol 8:4-11. 1990
    ..We did not observe any clinically important deleterious effects from this mechanism...
  46. ncbi Use of maximal expiratory flows to evaluate central airways obstruction in infants
    R S Tepper
    Department of Pulmonology, James Whitcomb Riley Hospital for Children, Indiana University Medical School, Indianapolis 46223
    Pediatr Pulmonol 6:272-4. 1989
    ..The PEFV curve adds to our physiologic assessment of the severity of the central airway obstruction in infants and to the efficacy of our therapeutic intervention...
  47. ncbi Spirometry and flow-volume curve in patients with obstructive sleep apnea
    Mohammad Ashraf
    Sleep Disorders Center, Department of Medicine, King Saud University, PO Box 225503, Riyadh 11324, Kingdom of Saudi Arabia
    Saudi Med J 29:198-202. 2008
    ..To assess the prevalence of spirometric abnormalities in obstructive sleep apnea (OSA) patients and its clinical utility in diagnosing OSA...
  48. ncbi [A case of early mucoepidermoid carcinoma arising from the left upper bronchus and presenting the flow-volume curve as a manner of extra-thoracic airway obstruction]
    H Kobayashi
    Department of Respiratory Disease, Saiseikai Utsunomiya Hospital, Tochigi
    Nihon Kyobu Shikkan Gakkai Zasshi 30:1554-7. 1992
    ..Sleeve lobectomy was performed, and the tumor was proved to be early lung cancer of hilar type with extension limited to the bronchial wall...
  49. ncbi [Lung function measurements with portable spirometers in children]
    C Casaulta Aebischer
    , , Inselspital, Bern
    Praxis (Bern 1994) 91:503-7. 2002
    ..The curve configuration enables diagnosis and allows assessment of the patient's cooperation. The readings are then used for quantifying analysis...
  50. ncbi Influence of a fibrothorax on the flow/volume curve
    C T Bolliger
    Department of Internal Medicine, University of Stellenbosch Medical School, Tygerberg, South Africa
    Respiration 54:197-200. 1988
    ..These changes caused by 'entrapment' of the lungs are described and illustrated by means of a case report of a patient with bilateral fibrothorax caused by bilateral tuberculous pleural effusions...
  51. ncbi Effects of increasing doses of beta-agonists on airway and parenchymal hysteresis
    Y T Wang
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    J Appl Physiol 68:363-8. 1990
    ..These data support the relative hysteresis analysis of airway and parenchyma as an explanation for volume history effects on airway caliber...
  52. ncbi Maximal expiratory flow volume curve in quarry workers
    Arcot Sadagopa Subhashini
    Department of Physiology, Sri Ramachandra Medical College and Research Institute, Chennai 600 116
    Indian J Physiol Pharmacol 46:78-84. 2002
    ..The effects are probably due to smoking rather than dust exposure...
  53. ncbi A survey of the current use and methods of analysis of bronchoprovocational challenges
    G C Scott
    Department of Medicine, University of Missouri Columbia Hospital and Clinics, Columbia 65212
    Chest 100:322-8. 1991
    ..The most common provocative agent utilized was methacholine (62 percent) and the most used delivery mode was a dosimeter (55 percent)...
  54. ncbi Maximal expiratory and inspiratory flow-volume curves in Parkinson's disease
    J M Bogaard
    Department of Pulmonary Disease, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands
    Am Rev Respir Dis 139:610-4. 1989
    ..The number of normal curves decreased from H-Y Group III to Group V. The contribution of A and B curves was relatively equal in the groups, with only a small number of A curves.(ABSTRACT TRUNCATED AT 250 WORDS)..
  55. ncbi Effect of a M1-selective muscarinic receptor antagonist (pirenzepine) on basal bronchomotor tone in young women
    M Fujimura
    Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan
    Respiration 59:102-6. 1992
    ..2 +/- 14.2%. These results suggest that the role of M1-receptors in vagally mediated basal bronchomotor tone may be significant but little compared with M3-receptors in normal humans...
  56. ncbi [The effect of inhaled salbutamol on pulmonary gas exchange in patients with chronic obstructive bronchopneumopathy]
    T Clerbaux
    , Cliniques Universitaires Saint Luc, Bruxelles, Belgique
    Rev Mal Respir 9:171-7. 1992
    ..It is concluded that salbutamol does not affect the blood gases in COPD patients. In this respect the behaviour of COPD patients differs from that of asthmatics in whom salbutamol generally induced hypoxemia...
  57. ncbi A five year follow-up of lung function among chemical workers using flow-volume and impedance measurements
    S Keman
    Dept of Health Risk Analysis and Toxicology, University of Limburg, Maastricht, The Netherlands
    Eur Respir J 9:2109-15. 1996
    ..It is concluded that alterations in impedance parameters do reflect changes in flow-volume curves induced by age. smoking and occupational exposure. Therefore, these data are a valuable extension to current cross-sectional data...
  58. pmc Comparison of the functional results of single lung transplantation for pulmonary fibrosis and chronic airway obstruction
    R A Chacon
    Department of Respiratory Medicine, Freeman Hospital, Newcastle, upon Tyne, UK
    Thorax 53:43-9. 1998
    ....
  59. ncbi [Characteristics of chord time constant and F-V curve configuration in testing small airway functions for smokers]
    G Huang
    Department of Physiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041
    Hua Xi Yi Ke Da Xue Xue Bao 30:280-2, 295. 1999
    ..Therefore it is concluded that in terms of clinical implications the specificity of tau ch50 for small airway functions and the prolongation of tau ch with the severity of COPD are useful indexes...
  60. ncbi Simulation of the effects of mechanical nonhomogeneities on expiratory flow from human lungs
    R K Lambert
    Department of Physics and Biophysics, Massey University, Palmerston North, New Zealand
    J Appl Physiol 68:2550-63. 1990
    ..delta PA was greater when the viscosity of the expired gas was increased or when its density was reduced. Partial forced expirations were shown to indicate the presence of mechanical nonhomogeneity...
  61. ncbi Assessment of the usefulness of helium-oxygen maximal expiratory flow curves in epidemiologic studies of lung disease in children
    S Redline
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115
    Am Rev Respir Dis 136:834-40. 1987
    ..The reproducibility of DD50 was assessed on a subsample of 90 subjects in whom DD was measured during 2 surveys 1 yr apart.(ABSTRACT TRUNCATED AT 250 WORDS)..
  62. ncbi Gas trapping in normal infants and in infants with cystic fibrosis
    Robert G Castile
    Children s Hospital, and Department of Pediatrics, Ohio State University, Columbus, Ohio 43205, USA
    Pediatr Pulmonol 37:461-9. 2004
    ..Measured following raised volume forced expiratory maneuvers, delta V and tg do not distinguish infants with CF from normal infants as well as do other currently available tests of infant lung function...
  63. ncbi Effects of thoracic gas compression on maximal and partial flow-volume maneuvers
    R D Fairshter
    University of California, Irvine Medical Center, Orange 92668
    J Appl Physiol 67:780-5. 1989
    ....
  64. ncbi Sources of error in flow-volume curves. Effect of expired volume measured at the mouth vs that measured in a body plethysmograph
    A L Coates
    Department of Pediatrics, McGill University, Canada
    Chest 94:976-82. 1988
    ..0001). These findings suggest that expiratory flows in the FVCm are not effort-independent in the face of significant airflow obstruction and that comparisons of values derived from an FVCp with those from an FVCm may not be valid...
  65. ncbi Serum eosinophil cationic protein (ECP) in chronic asthma. Relationship to spirometry, flow-volume curves, PC20, and exacerbations
    A M Wever
    Department of Respiratory Medicine, Red Cross Hospital, The Hague, The Netherlands
    Respir Med 88:613-21. 1994
    ..Elevated ECP seems to denote patients at risk from inflammatory exacerbations, resulting in practical implications for the therapeutic management of chronic asthma...
  66. ncbi Measurement of respiratory impedance by forced oscillation: comparison of the standard and head generator methods
    Y Iwatsubo
    INSERM U139, , France
    Eur Respir J 7:901-6. 1994
    ..According to our results, the standard method of applying forced oscillation at the mouth seems an acceptable device for measuring respiratory impedance for epidemiological purposes...
  67. ncbi [Study of peak expiratory flow in 728 normal adolescents in Chengdu area]
    G Huang
    Department of Physiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China
    Hua Xi Yi Ke Da Xue Xue Bao 32:427-9. 2001
    ....
  68. ncbi [Clinical study of the month: the TORCH study (TOwards a Revolution in COPD Health)]
    J L Corhay
    Service de Pneumologie, CHU Sart Tilman, Liege, Belgique
    Rev Med Liege 62:230-4. 2007
    ..In addition to being effective, the combination salmeterol/fluticasone (50/500 microg 2x/day) is well tolerated in COPD and had a favourable benefit/risk ratio...
  69. ncbi Role of vagus nerves in resiniferatoxin-induced bronchoconstriction of guinea pigs
    H Q Zhang
    Division of Pharmacology and Experimental Therapeutics, University of Kentucky College of Pharmacy, Lexington 40536
    Respir Physiol 94:285-95. 1993
    ..Thus, the nonvagal component plays a significant role in this type of tachykinin-mediated airway constriction...
  70. ncbi Growth of airways and air spaces in teenagers is related to sex but not to symptoms
    P J Merkus
    Department of Physiology, Leiden University, The Netherlands
    J Appl Physiol (1985) 75:2045-53. 1993
    ..However, no difference in patterns of lung growth was observed in association with the presence of respiratory symptoms...
  71. ncbi Lower airway obstruction, bronchial hyperresponsiveness, and primary pulmonary hypertension in children
    Deepa Rastogi
    Division of Pediatric Pulmonology, Department of Pediatrics, College of Physicians and Surgeons of Columbia University and the Morgan Stanley Children s Hospital of New York Presbyterian, New York, New York 10032, USA
    Pediatr Pulmonol 37:50-5. 2004
    ..Our findings suggest that reversible LAO is the most common lung function abnormality among pediatric patients with PPH. Whether airway reactivity is a cause of or the result of PPH remains to be determined...
  72. ncbi Expiratory muscle fatigue does not regulate operating lung volumes during high-intensity exercise in healthy humans
    Bryan J Taylor
    Centre for Sports Medicine and Human Performance, Brunel University, London, United Kingdom
    J Appl Physiol (1985) 114:1569-76. 2013
    ....
  73. pmc Changes in maximum expiratory flow-volume curve configuration after treatment with inhaled corticosteroids
    J Kraan
    Department of Lung Disease, University Hospital, Groningen, The Netherlands
    Thorax 44:1015-21. 1989
    ..It is concluded that these changes in flow-volume curve configuration reflect a decrease in inhomogeneously distributed inflammatory airway narrowing...
  74. ncbi Simulation of airway closure during forced vital capacity
    D Elad
    Biomedical Engineering Program, Faculty of Engineering, Tel Aviv University, Israel
    Ann Biomed Eng 17:617-31. 1989
    ..It can reproduce either the abrupt fall in maximal expiratory flow-volume curves as observed in dog lungs or the gradual decrease that has been observed in humans...
  75. ncbi Reference values of total respiratory resistance, determined with the "opening" interruption technique
    P H Vooren
    Department of Pulmonary Diseases, University Hospital, Leiden, Holland
    Eur Respir J 2:966-71. 1989
    ..However, it appears to be useful in histamine challenge testing, to detect and monitor bronchial asthma, being not subjected to the disturbing effect of forced ins- and expirations...
  76. ncbi Smoking and cotton dust effects in cotton textile workers
    E N Schachter
    Department of Internal Medicine, Mount Sinai School of Medicine, New York City 10029
    Chest 95:997-1003. 1989
    ..We suggest that morphologic patterns of flow volume curves reflect separate effects of cotton dust exposure and smoking and may be related to different sites of airway injury...
  77. ncbi Cough flow-volume relationships in normal and asthmatic children
    C S Beardsmore
    Department of Child Health, University of Leicester, England
    Pediatr Pulmonol 6:223-31. 1989
    ..These changes are related to alterations in airway compliance and cross-sectional area and are partly reversed following inhalation of a bronchodilator...
  78. ncbi Elastic properties of the respiratory system in infants with cystic fibrosis
    Robert S Tepper
    Department of Pediatrics, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, 702 Barnhill Drive, Room 4270, Indianapolis, IN 46202 5225, USA
    Am J Respir Crit Care Med 170:505-7. 2004
    ..Our findings indicate that infants with CF have normal elastic properties of the respiratory system...
  79. ncbi [Configurations of F-V curve and their transformation rule in COPD patients analysed with wave-speed theory]
    G Huang
    Department of Physiology, School of Basic Medical Sciences, WCUMS, Chengdu, 610041
    Hua Xi Yi Ke Da Xue Xue Bao 31:387-91. 2000
    ..This implicates a unifying process of pulmonary functions from healthy state to weakness and from slight to serious abnormality...
  80. pmc Effects of posture on flow-volume curves during normocapnia and hypercapnia in patients with obstructive sleep apnoea
    C Miura
    First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Thorax 47:524-8. 1992
    ..CONCLUSION: In patients with obstructive sleep apnoea the upper airway is prone to collapse during inspiration when the patient is supine, even when awake; this tendency can be reversed by breathing carbon dioxide...
  81. ncbi The flow/volume curve as a mass screening test with emphasis on quality control
    M A de Kock
    Department of Internal Medicine, University of Stellenbosch
    S Afr Med J 75:261-70. 1989
    ..It is recommended that hard copies of the three efforts must be available and that all flow/volume measurements be controlled by a knowledgeable person before the results are entered in the records...
  82. ncbi Removal of observer variability from the determination of the volume of isoflow
    R K Lambert
    Department of Physics and Biophysics, Massey University, Palmerston North, New Zealand
    Lung 165:353-69. 1987
    ..Plots of DD (derived from heavily filtered flow curves) vs. lung inflation showed an unambiguous value for VisoV...
  83. pmc Rate of increase in pulmonary distensibility in a longitudinal study of smokers
    H J Colebatch
    Department of Respiratory Medicine, University of New South Wales, Prince Henry Hospital, Australia
    Thorax 43:175-82. 1988
    ..In this study the rate of increase in K and the variation between subjects was sufficient to explain the magnitude of the increased pulmonary distensibility found in cigarette smokers who present with emphysema...
  84. ncbi Sidestream cigarette smoke exposure and airway reactivity during early life
    Y L Lai
    Division of Pharmacology and Experimental Therapeutics, University of Kentucky College of Pharmacy, Lexington 40536
    J Appl Physiol 77:1868-74. 1994
    ..These results indicate that chronic neonatal SSCS exposure induces bronchial hyperreactivity to SP; this hyperreactivity is abolished by capsaicin pretreatment...
  85. ncbi Rigid external resistances cause effort dependent maximal expiratory and inspiratory flows
    C F Melissant
    Department of Pneumology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Respir Crit Care Med 152:1709-12. 1995
    ..We concluded that external resistances cause a MEF50/MIF50 ratio of clearly more than 1 and that this is determined by the PE/(-)PI ratio, which in healthy subjects is markedly larger than 1...
  86. ncbi Exhaled flow monitoring can detect bronchial flap-valve obstruction in a mechanical lung model
    P H Breen
    Department of Anesthesiology, University of California at Irvine Medical Center, Orange, CA 92613, USA
    Anesth Analg 81:292-6. 1995
    ..In this mechanical lung model, we conclude that bronchial flap-valve obstruction was best detected by the flow-time plot, which could measure the sequential emptying of the lungs...
  87. ncbi Nasal and oral flow-volume loops in normal subjects and patients with obstructive sleep apnea
    J W Shepard
    Mayo Sleep Disorders Center, Mayo Clinic, Rochester, Minnesota 55905
    Am Rev Respir Dis 142:1288-93. 1990
    ..89. These results suggest that limitations to ventilation via the nasopharynx may significantly influence both gas exchange and the frequency of sleep-disordered breathing in patients with OSA.(ABSTRACT TRUNCATED AT 250 WORDS)..
  88. ncbi Expression of thioredoxin-binding protein-2/vitamin D3 upregulated protein-1 in peripheral blood eosinophils of asthma patients
    Feng Gao
    Department of Respiratory Diseases, Nanfang Hospital, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:371-5. 2006
    ..To investigate the expression of vitamin D3 upregulated protein-1 (VDUP1) in peripheral eosinophils at different stages of asthma and its correlation with clinical manifestations of asthma...
  89. ncbi Partial flow/volume curves and airway resistances in obese subjects: new tools for investigating flow limitation?
    R Drigo
    Divisione di Pneumotisiologia, Ospedale S Maria del Prato, Feltre BL
    Monaldi Arch Chest Dis 65:118-22. 2006
  90. ncbi Spirometric and flow-volume curve analysis in rats, and optimal parameters for estimating obstructive impairment
    Tetsuri Kondo
    Department of Respiratory Medicine, Tokai University Hachioji Hospital, Hachioji, Tokyo, 192 0032, Japan
    J Physiol Sci 60:309-16. 2010
    ..In conclusion, PEFR and FVC are optimal parameters for estimation of bronchoconstriction in rats. The decreases in PEFR and FVC may reflect constriction in large and smaller airways, respectively...
  91. ncbi Advantages of late expiratory relaxation during maximal forced expiratory maneuver
    S K Chhabra
    Department of Cardiorespiratory Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India
    Indian J Chest Dis Allied Sci 43:205-10. 2001
    ....
  92. ncbi Mucociliary clearance in adult asthma
    J Zwang
    Department of Medicine, State University of New York, Stony Brook 11794 8172
    Am Rev Respir Dis 146:598-603. 1992
    ..Throughout the 2-h study period, retention by the FL group was significantly greater than that of the NFL group with separation of 95% confidence intervals.(ABSTRACT TRUNCATED AT 250 WORDS)..
  93. ncbi Effectiveness of pressure support ventilation for mechanical ventilatory support in patients with status asthmaticus
    H Tokioka
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Japan
    Acta Anaesthesiol Scand 36:5-9. 1992
    ..The oxygen cost of breathing estimated by oxygen consumption was equivalent in both modes. We conclude that PSV is effective in supplying tidal volumes adequate to improve hypercarbia at markedly lower airway pressures than ACV...
  94. ncbi Ventilatory parameters in healthy nonsmoking adults of Adriatic islands (Yugoslavia)
    N Smolej-Narancic
    Dept of Anthropology, University of Zagreb, Yugoslavia
    Eur Respir J 4:955-64. 1991
    ..Comparisons were made with prediction equations derived for other populations, especially with those which are commonly used in daily medical practice...
  95. ncbi Maximum expiratory flow-volume curves during short periods of microgravity
    H J Guy
    Department of Medicine, University of California, San Diego, La Jolla 92093
    J Appl Physiol 70:2587-96. 1991
    ....
  96. ncbi [Correlation of parameters of the flow-volume curve for the assessment of bronchial hyperreactivity]
    M Schwaiblmair
    Medizinische Klinik I,
    Pneumologie 45:15-8. 1991
    ..We concluded that the flow rates at middle and low lung volumes may be an important determinant of bronchial sensitivity to acetylcholine...
  97. ncbi Effects of deep inhalation during early and late asthmatic reactions to allergen
    R Pellegrino
    Servizio di Fisiopathologia Respiratoria, Ospedale A Carle, Italy
    Am Rev Respir Dis 142:822-5. 1990
    ..This may result from an increased parenchymal hysteresis (more peripherally located bronchial obstruction) or a decreased airway hysteresis (prominent airway inflammation) during the late phase reaction...
  98. ncbi [Studies of normal values and prediction equations for pulmonary function--spirometry and flow-volume measurements in healthy Japanese children 6 to 14 years of age]
    M Miyazawa
    Saitama Institute of Public Health, Urawa
    Rinsho Byori 38:1181-92. 1990
    ..The predicted values derived from our equations were larger than those obtained from the other studies published in Japan. The difference is probably due to the improvement in the body size of Japanese children and the equipments used...
  99. pmc Airway function in infants with vascular rings: preoperative and postoperative assessment
    A H Thomson
    Department of Child Health, University of Leicester
    Arch Dis Child 65:171-4. 1990
    ....
  100. ncbi Tracking of lung function in healthy children and adolescents
    M E Hibbert
    Department of Thoracic Medicine, Royal Children s Hospital, Melbourne, Australia
    Pediatr Pulmonol 8:172-7. 1990
    ..The data indicate that these measurements of lung function in healthy individuals grow in constant proportion relative to other healthy children and adolescents...
  101. ncbi [Spirometry for the primary care physician? For which patient?]
    Pierre Yves Jayet
    Service de Pneumologie, CHUV, 1011 Lausanne
    Rev Med Suisse 2:2592-4, 2597. 2006
    ..Expert recommendations, regularly updated by the American and European respiratory societies, specify the necessary conditions for spirometry to provide useful information for the care of patients...

Research Grants2

  1. Airway as Target Organ in Infants with Atopic Dermatitis
    Robert Tepper; Fiscal Year: 2008
    ..Specific Aim # 2: Evaluate whether the presence of phenotypic characteristics of the asthmatic airway identifies infants and toddlers that develop clinical asthma by 5 years of age. [unreadable] [unreadable]..
  2. GROWTH OF AIRWAYS AND LUNG PARENCHYMA IN NORMAL INFANTS
    Robert Tepper; Fiscal Year: 2009
    ..abstract_text> ..