tidal volume

Summary

Summary: The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.

Top Publications

  1. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
  2. ncbi Assessment of tidal volume and gas leak during mask ventilation of preterm infants in the delivery room
    Georg M Schmölzer
    Neonatal Services, Department of Newborn Research, The Royal Women s Hospital, Melbourne, Australia
    Arch Dis Child Fetal Neonatal Ed 95:F393-7. 2010
  3. ncbi Effect of sustained inflation length on establishing functional residual capacity at birth in ventilated premature rabbits
    Arjan B Te Pas
    Neonatal Services, Royal Women s Hospital, Parkville, Victoria 3053, Australia
    Pediatr Res 66:295-300. 2009
  4. ncbi Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal
    Pier Paolo Terragni
    Dipartimento di Anestesiologia e Medicina degli Stati Critici, Universita di Torino, Ospedale S Giovanni Battista Molinette, Corso Dogliotti 14, Turin, Italy
    Anesthesiology 111:826-35. 2009
  5. ncbi Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome
    Davide Chiumello
    Dipartimento di Anestesia, Rianimazione, Intensiva e Subintensivae, Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Am J Respir Crit Care Med 178:346-55. 2008
  6. ncbi What tidal volumes should be used in patients without acute lung injury?
    Marcus J Schultz
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, University of Amsterdam, and Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 106:1226-31. 2007
  7. ncbi High-frequency percussive ventilation and low tidal volume ventilation in burns: a randomized controlled trial
    Kevin K Chung
    U S Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Crit Care Med 38:1970-7. 2010
  8. ncbi Variable ventilation induces endogenous surfactant release in normal guinea pigs
    Stephen P Arold
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Am J Physiol Lung Cell Mol Physiol 285:L370-5. 2003
  9. pmc Influence of low tidal volume ventilation on time to extubation in cardiac surgical patients
    Sugantha Sundar
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Anesthesiology 114:1102-10. 2011
  10. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003

Detail Information

Publications328 found, 100 shown here

  1. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
    ..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support...
  2. ncbi Assessment of tidal volume and gas leak during mask ventilation of preterm infants in the delivery room
    Georg M Schmölzer
    Neonatal Services, Department of Newborn Research, The Royal Women s Hospital, Melbourne, Australia
    Arch Dis Child Fetal Neonatal Ed 95:F393-7. 2010
    The aim was to compare resuscitators' estimates of tidal volume (V(T)) and face mask leak with measured values during positive pressure ventilation (PPV) of newborn infants in the delivery room.
  3. ncbi Effect of sustained inflation length on establishing functional residual capacity at birth in ventilated premature rabbits
    Arjan B Te Pas
    Neonatal Services, Royal Women s Hospital, Parkville, Victoria 3053, Australia
    Pediatr Res 66:295-300. 2009
    ..4 (19.3-30.4) mL/kg for 20-s SI. The lung was uniformly aerated, and the FRC and tidal volume fully recruited after 20-s SI. A 10-s SI caused a higher FRC (p < 0...
  4. ncbi Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal
    Pier Paolo Terragni
    Dipartimento di Anestesiologia e Medicina degli Stati Critici, Universita di Torino, Ospedale S Giovanni Battista Molinette, Corso Dogliotti 14, Turin, Italy
    Anesthesiology 111:826-35. 2009
    Tidal hyperinflation may occur in patients with acute respiratory distress syndrome who are ventilated with a tidal volume (VT) of 6 ml/kg of predicted body weight develop a plateau pressure (PPLAT) of 28 < or = PPLAT < or = 30 cm ..
  5. ncbi Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome
    Davide Chiumello
    Dipartimento di Anestesia, Rianimazione, Intensiva e Subintensivae, Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Am J Respir Crit Care Med 178:346-55. 2008
    ..Lung injury caused by a ventilator results from nonphysiologic lung stress (transpulmonary pressure) and strain (inflated volume to functional residual capacity ratio)...
  6. ncbi What tidal volumes should be used in patients without acute lung injury?
    Marcus J Schultz
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, University of Amsterdam, and Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 106:1226-31. 2007
    ..Prospective studies should be performed to evaluate optimal ventilator management strategies for patients without ALI...
  7. ncbi High-frequency percussive ventilation and low tidal volume ventilation in burns: a randomized controlled trial
    Kevin K Chung
    U S Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Crit Care Med 38:1970-7. 2010
    ..found an absence of prospective studies comparing high-frequency percussive ventilation with contemporary low-tidal volume ventilation strategies...
  8. ncbi Variable ventilation induces endogenous surfactant release in normal guinea pigs
    Stephen P Arold
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Am J Physiol Lung Cell Mol Physiol 285:L370-5. 2003
    Variable or noisy ventilation, which includes random breath-to-breath variations in tidal volume (Vt) and frequency, has been shown to consistently improve blood oxygenation during mechanical ventilation in various models of acute lung ..
  9. pmc Influence of low tidal volume ventilation on time to extubation in cardiac surgical patients
    Sugantha Sundar
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Anesthesiology 114:1102-10. 2011
    ..The role of low tidal volume ventilation in patients without lung injury is still unresolved...
  10. ncbi Influence of tidal volume on left ventricular stroke volume variation measured by pulse contour analysis in mechanically ventilated patients
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 29:476-80. 2003
    ..This study investigated the influence of the depth of tidal volume (V(t)) on SVV both during the state of fluid responsiveness and after fluid loading in mechanically ventilated ..
  11. ncbi Accuracy of stroke volume variation in predicting fluid responsiveness: a systematic review and meta-analysis
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Central Hospital, 351 Mingyue Road, Jinhua, 321000, Zhejiang, People s Republic of China
    J Anesth 25:904-16. 2011
    ..We therefore undertook a systematic review and meta-analysis of clinical trials that investigated the diagnostic value of SVV in predicting fluid responsiveness...
  12. pmc Synthetic surfactant based on analogues of SP-B and SP-C is superior to single-peptide surfactants in ventilated premature rabbits
    Andreas Almlén
    Department of Molecular Medicine and Surgery, Section of Clinical Chemistry, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Neonatology 98:91-9. 2010
    ....
  13. ncbi Assessment of chest rise during mask ventilation of preterm infants in the delivery room
    David A Poulton
    The University of Aberdeen Medical School, Aberdeen, Scotland, UK
    Resuscitation 82:175-9. 2011
    ..The accuracy of this assessment has not been tested. We compared the assessment of chest rise made by observers standing at the infants' head and at the infants' side with measurements of tidal volume.
  14. pmc Inflammation and lung maturation from stretch injury in preterm fetal sheep
    Noah H Hillman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 300:L232-41. 2011
    ..Fifteen minutes of high tidal volume (V(T)) ventilation induces inflammatory cytokine expression in small airways and lung parenchyma within 3 h...
  15. ncbi The effects of tidal volume and respiratory rate on oxygenation and respiratory mechanics during laparoscopy in morbidly obese patients
    Juraj Sprung
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA
    Anesth Analg 97:268-74, table of contents. 2003
    ..We hypothesized that increases in tidal volume (V(T)) or respiratory rate (RR) would improve oxygenation...
  16. pmc Mechanical ventilation with high tidal volume induces inflammation in patients without lung disease
    Roselaine Pinheiro de Oliveira
    Central Intensive Care Unit, Complexo Hospitalar Santa Casa, Rua Prof, Annes Dias, Porto Alegre, Brazil
    Crit Care 14:R39. 2010
    ..We compared the effects of a protective versus a conventional ventilatory strategy, on systemic and lung production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) in patients without lung disease...
  17. ncbi Perioperative tidal volume and intra-operative open lung strategy in healthy lungs: where are we going?
    Beatrice Beck-Schimmer
    Institute of Anaesthesiology, University Hospital Zurich, Zurich, Switzerland
    Best Pract Res Clin Anaesthesiol 24:199-210. 2010
    ..few randomised controlled trials have been performed to date, focussing on the use of the best intra-operative tidal volume. The same problem has been observed regarding the application of positive end-expiratory pressure (PEEP) and ..
  18. ncbi Implementation and interpretation of respiratory sinus arrhythmia measures in psychosomatic medicine: practice against better evidence?
    Thomas Ritz
    Department of Psychology, Southern Methodist University, Dallas, Texas 75205, USA
    Psychosom Med 68:617-27. 2006
    ..However, their dependency on both respiration rate and tidal volume is largely ignored...
  19. ncbi ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure
    Salvatore Grasso
    Universita di Bari, Dipartimento dell Emergenza e Trapianti d Organo DETO, Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Piazza Giulio Cesare 11, Bari 70124, Italy
    Am J Respir Crit Care Med 176:761-7. 2007
    ....
  20. ncbi Prediction of fluid responsiveness in acute respiratory distress syndrome patients ventilated with low tidal volume and high positive end-expiratory pressure
    Chung Chi Huang
    Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Gweishan, Taoyuan, Taiwan
    Crit Care Med 36:2810-6. 2008
    ..However, they are influenced by tidal volume and the level of positive end-expiratory pressure...
  21. ncbi Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
    Peter M Spieth
    Department of Anesthesiology and Intensive Care Therapy, University Hospital Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Am J Respir Crit Care Med 179:684-93. 2009
    ..Noisy ventilation with variable Vt may improve respiratory function in acute lung injury...
  22. pmc Toll-like receptor 4 mediates neutrophil sequestration and lung injury induced by endotoxin and hyperinflation
    Guochang Hu
    Departments of Pharmacology, University of Illinois, Chicago, IL, USA
    Crit Care Med 38:194-201. 2010
    ..Infiltration of polymorphonuclear neutrophils into the lung is an important feature of ventilator-induced lung injury associated with pneumonia, but the mechanisms involved in neutrophil recruitment are poorly understood...
  23. ncbi Meta-analysis: ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury
    Christian Putensen
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Ann Intern Med 151:566-76. 2009
    ..Trials have provided conflicting results regarding the effect of different ventilatory strategies on the outcomes of patients with the acute respiratory distress syndrome (ARDS) and acute lung injury...
  24. pmc Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, Perth, Western Australia, 6009, Australia
    Pediatr Res 64:517-22. 2008
    ..We aimed to evaluate whether PEEP and/or tidal volume (VT) within the first 15-min of ventilation are protective against lung injury...
  25. ncbi Ventilation-mediated injury after preterm delivery of Ureaplasma parvum colonized fetal lambs
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, Subiaco, Western Australia 6009, Australia
    Pediatr Res 67:630-5. 2010
    ..Antenatal colonization with UP did not change lung function or modulate the lung injury and inflammation caused by high VT ventilation...
  26. ncbi Regional filling characteristics of the lungs in mechanically ventilated patients with acute lung injury
    J Hinz
    University of Gottingen, Emergency and Intensive Care Medicine, Department of Anaesthesiology, Gottingen, Germany
    Eur J Anaesthesiol 24:414-24. 2007
    ..The objective of the study was to determine regional pulmonary filling characteristics in 20 mechanically ventilated patients with acute lung injury...
  27. ncbi The prediction of extubation success of postoperative neurosurgical patients using frequency-tidal volume ratios
    Milena C Vidotto
    Respiratory Physiotherapy Especialization Course, Federal University of Sao Paulo UNIFESP, Sao Paulo, Brazil
    Neurocrit Care 9:83-9. 2008
    ..The aim of this study was to report the outcome from extubating patients undergoing elective craniotomy and correlate the result with the measured f/V (t) ratio...
  28. ncbi Electrical impedance tomography: a method for monitoring regional lung aeration and tidal volume distribution?
    Inez Frerichs
    Department of Anaesthesiological Research, Centre of Anaesthesiology, Emergency and Intensive Care Medicine, University of Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Intensive Care Med 29:2312-6. 2003
    To demonstrate the monitoring capacity of modern electrical impedance tomography (EIT) as an indicator of regional lung aeration and tidal volume distribution.
  29. ncbi Effect of low tidal volume ventilation on atelectasis in patients during general anesthesia: a computed tomographic scan
    Hongwei Cai
    Department of Anesthesiology and Intensive Care Medicine, Xiangya Hospital, Central Southern University, Changsha, 41008, China
    J Clin Anesth 19:125-9. 2007
    ..To determine whether low tidal ventilation in patients without lung injury results in an increase in the amount of atelectasis and a further impairment of gas exchange during general anesthesia...
  30. pmc How safe is intermittent positive pressure ventilation in preterm babies ventilated from delivery to newborn intensive care unit?
    M Tracy
    Department of Paediatrics and Child Health Sydney University, Nepean Hospital, Sydney, NSW 2747, Australia
    Arch Dis Child Fetal Neonatal Ed 89:F84-7. 2004
    ..Further, to examine the usefulness of tidal volume and minute ventilation measurements at this time.
  31. ncbi Evaluation of an electrical impedance tomography-based Global Inhomogeneity Index for pulmonary ventilation distribution
    Zhanqi Zhao
    Section for Experimental Anesthesiology, Department of Anesthesiology and Critical Care Medicine, University Medical Center, Freiburg, Germany
    Intensive Care Med 35:1900-6. 2009
    ..To evaluate the plausibility, stability, and interindividual comparability of the global inhomogeneity index (GI) based on electrical impedance tomography (EIT)...
  32. ncbi Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury
    Stephen P Arold
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Am J Respir Crit Care Med 165:366-71. 2002
    Random variations in breath rate and tidal volume during mechanical ventilation in the setting of acute lung injury have been shown to improve arterial oxygen tension...
  33. ncbi Effect of a clinical decision support system on adherence to a lower tidal volume mechanical ventilation strategy
    Saeid Eslami
    Department of Medical Informatics, Academic Medical Center, Universiteit van Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Crit Care 24:523-9. 2009
    The purpose of the study was to measure the effect of a computerized decision support system (CDSS) on adherence to tidal volume (V(T)) recommendations.
  34. pmc Effect of PEEP and tidal volume on ventilation distribution and end-expiratory lung volume: a prospective experimental animal and pilot clinical study
    Günther Zick
    University Medical Center Schleswig Holstein, Campus Kiel, Department of Anesthesiology and Intensive Care Medicine, Kiel, Germany
    PLoS ONE 8:e72675. 2013
    ....
  35. ncbi A positive response to a recruitment maneuver with PEEP titration in patients with ARDS, regardless of transient oxygen desaturation during the maneuver
    Carol L Hodgson
    The Alfred Hospital, Melbourne, Australia, Monash University, Melbourne, Australia
    J Intensive Care Med 26:41-9. 2011
    ..Recruitment maneuvers (RMs) can expand collapsed alveoli in ventilated patients. The optimal method for delivering RMs is unknown...
  36. ncbi Distribution of regional lung aeration and perfusion during conventional and noisy pressure support ventilation in experimental lung injury
    Alysson R Carvalho
    Clinic of Anesthesiology and Intensive Care Therapy, Univ Hospital Dresden, Dresden, Germany
    J Appl Physiol (1985) 110:1083-92. 2011
    ..The driving pressure was set to a mean tidal volume of 6 ml/kg and positive end-expiratory pressure to 8 cmH₂O in all modes...
  37. ncbi The effect of tidal volume on systemic inflammation in Acid-induced lung injury
    Melissa G Walker
    Lawson Health Research Institute, London, Ont, Canada
    Respiration 81:333-42. 2011
    ..Previous studies suggest that mechanical ventilation (MV) may be a key mediator of MOF through an upregulation of the systemic inflammatory response...
  38. ncbi Comparison of variable and conventional ventilation in a sheep saline lavage lung injury model
    Carissa L Bellardine
    Department of Biomedical Engineering, Boston University, Boston, MA, USA
    Crit Care Med 34:439-45. 2006
    ..We aimed at testing VV in a large animal lung injury model and exploring the mechanism of improvement in gas exchange seen with VV...
  39. ncbi Influence of respiratory rate on gas trapping during low volume ventilation of patients with acute lung injury
    Jean Christophe Richard
    Medical Intensive Care Unit, University Hospital Charles Nicolle, 1 rue de Germont, 76031 Rouen, France
    Intensive Care Med 28:1078-83. 2002
    Reduction in tidal volume (Vt) associated with increase in respiratory rate to limit hypercapnia is now proposed in patients with acute lung injury (ALI)...
  40. ncbi The influence of tidal volume on the dynamic variables of fluid responsiveness in critically ill patients
    Cyril Charron
    Service d Anesthésie Réanimation et Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil UPRES EA 3540, Le Kremlin Bicetre, France
    Anesth Analg 102:1511-7. 2006
    ..We investigated the influence of tidal volume (Vt) and adrenergic tone on these variables in mechanically ventilated patients...
  41. ncbi Effect of tidal volume on distribution of ventilation assessed by synchrotron radiation CT in rabbit
    L Porra
    Department of Physical Sciences, University of Helsinki, Helsinki FIN 00014, Finland
    J Appl Physiol (1985) 96:1899-908. 2004
    ..allows visualization and direct quantification of inhaled stable xenon gas, was used to study the effect of tidal volume (Vt) on regional lung ventilation. High-resolution maps (pixel size 0.35 x 0...
  42. ncbi Effects of tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome
    Richard H Kallet
    Critical Care Division, Department of Anesthesia, University of California, San Francisco at San Francisco General Hospital, San Francisco, CA 94110, USA
    Crit Care Med 34:8-14. 2006
    To assess the effects of step-changes in tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury (ALI) or the acute respiratory distress syndrome (ARDS).
  43. ncbi Pentraxin 3 accelerates lung injury in high tidal volume ventilation in mice
    Juliana Monte Real
    Hospital Sirio Libanes, Sao Paulo, Brazil
    Mol Immunol 51:82-90. 2012
    ..Genetically modified mice deficient and that over express murine Ptx3 gene were subjected to high tidal volume ventilation (V(T)=45 mL/kg, PEEP(zero))...
  44. ncbi Patient-ventilator interaction during pressure support ventilation and neurally adjusted ventilatory assist
    Jadranka Spahija
    Critical Care Unit, Sacre Coeur Hospital, University of Montreal, Montreal, Quebec, Canada
    Crit Care Med 38:518-26. 2010
    ..Increasing the level of pressure support ventilation can increase tidal volume, reduce respiratory rate, and lead to delayed ventilator triggering and cycling...
  45. ncbi The effect of mechanical ventilation tidal volume during pneumoperitoneum on shoulder pain after a laparoscopic appendectomy
    Hwa Yong Shin
    Department of Anesthesiology and Pain Medicine, Konkuk University School of Medicine, 1 Hwayang dong, Gwanggin Gu, Seoul 143 701, South Korea
    Surg Endosc 24:2002-7. 2010
    ..the phrenic nerve with carbon dioxide gas against the constantly pressurized abdominal cavity with increasing tidal volume (V(T))...
  46. ncbi Pumpless extracorporeal removal of carbon dioxide combined with ventilation using low tidal volume and high positive end-expiratory pressure in a patient with severe acute respiratory distress syndrome
    T Bein
    Department of Anaesthesia and Intensive Care, University Hospital of Regensburg, Regensburg, Germany
    Anaesthesia 64:195-8. 2009
    ..Reducing tidal volume to 3 ml...
  47. ncbi Dyspnea and decreased variability of breathing in patients with restrictive lung disease
    Thomas Brack
    Division of Pulmonary and Critical Care Medicine, Edward Hines Jr, Veterans Affairs Hospital, Hines, Illinois 60141, USA
    Am J Respir Crit Care Med 165:1260-4. 2002
    ..variability was reduced in patients with restrictive lung disease: 27 times for expiratory time, 12 times for tidal volume, and 6 times for inspiratory time (p < 0.01 in each instance)...
  48. pmc Effect of tidal volume, sampling duration, and cardiac contractility on pulse pressure and stroke volume variation during positive-pressure ventilation
    Hyung Kook Kim
    Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 36:2858-62. 2008
    ..b>Tidal volume and contractility may also alter pulse pressure variation and stroke volume variation...
  49. ncbi Comparison of optimal positive end-expiratory pressure and recruitment maneuvers during lung-protective mechanical ventilation in patients with acute lung injury/acute respiratory distress syndrome
    Michel Badet
    Service de Réanimation Médicale et Assistance Respiratoire, Hopital de la Croix Rousse, 69004 Lyon, France
    Respir Care 54:847-54. 2009
    ..Recruitment maneuvers are closely linked to the selection of positive end-expiratory pressure (PEEP), which is also a subject of debate...
  50. ncbi Role for nuclear factor-kappaB in augmented lung injury because of interaction between hyperoxia and high stretch ventilation
    Yung Yang Liu
    Chest Department, Taipei Veterans General Hospital, and National Yang Ming University, School of Medicine, Taipei, Taiwan
    Transl Res 154:228-40. 2009
    ..We conclude that hyperoxia increased high-tidal-volume-induced cytokine production and neutrophil influx through activation of the NF-kappaB pathway...
  51. ncbi Variable ventilation improves perioperative lung function in patients undergoing abdominal aortic aneurysmectomy
    Abdulaziz Boker
    Department of Anesthesia and Critical Care, Abdulaziz University, Jeddah, Saudi Arabia
    Anesthesiology 100:608-16. 2004
    ..that "noisy" or variable ventilation (VV)--return of physiologic variability to respiratory rate and tidal volume--improves lung function compared with monotonous control mode ventilation (CV)...
  52. ncbi Visual validation of the mechanical stabilizing effects of positive end-expiratory pressure at the alveolar level
    U G McCann
    Department of Surgery, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210. USA
    J Surg Res 99:335-42. 2001
    ..were measured with computer image analysis at end inspiration and expiration over consecutive increases in tidal volume (7, 10, 15, 20, and 30 cc/kg.) I - E(Delta) was calculated for each alveolus...
  53. ncbi Prediction of fluid responsiveness in patients during cardiac surgery
    S Rex
    Department of Anaesthesiology, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Br J Anaesth 93:782-8. 2004
    ..Left ventricular stroke volume variation (SVV) has been shown to be a predictor of fluid responsiveness in various subsets of patients. However, the accuracy and reliability of SVV are unproven in patients ventilated with low tidal volumes...
  54. pmc PEEP titration guided by ventilation homogeneity: a feasibility study using electrical impedance tomography
    Zhanqi Zhao
    Department of Biomedical Engineering, Furtwangen University, Jakob Kienzle Strasse 17, D 78054 Villingen Schwenningen, Germany
    Crit Care 14:R8. 2010
    Lung protective ventilation requires low tidal volume and suitable positive end-expiratory pressure (PEEP). To date, few methods have been accepted for clinical use to set the appropriate PEEP...
  55. ncbi Early changes in lung gene expression due to high tidal volume
    Ian B Copland
    Department of Critical Care, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Respir Crit Care Med 168:1051-9. 2003
    The purpose of this study was to use gene expression profiling to understand how adult rat lung responds to high tidal volume (HV) ventilation in vivo...
  56. ncbi Design of a new variable-ventilation method optimized for lung recruitment in mice
    Apiradee Thammanomai
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    J Appl Physiol (1985) 104:1329-40. 2008
    Variable ventilation (VV), characterized by breath-to-breath variation of tidal volume (Vt) and breathing rate (f), has been shown to improve lung mechanics and blood oxygenation during acute lung injury in many species compared with ..
  57. ncbi Mechanical ventilation affects inflammatory mediators in patients undergoing cardiopulmonary bypass for cardiac surgery: a randomized clinical trial
    Enrico Zupancich
    Servizio di Anestesia e Rianimazione, Azienda Ospedaliera Cardiologico G M Lancisi, Ancona, Italy
    J Thorac Cardiovasc Surg 130:378-83. 2005
    ..We examined the hypothesis that high tidal volumes and low levels of positive end-expiratory pressure might worsen the inflammatory response associated to cardiopulmonary bypass...
  58. pmc Mechanical ventilation guided by esophageal pressure in acute lung injury
    Daniel Talmor
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston 02215, USA
    N Engl J Med 359:2095-104. 2008
    ....
  59. ncbi Is pulmonary resistance constant, within the range of tidal volume ventilation, in patients with ARDS?
    G Mols
    Department of Anaesthesiology and Critical Care Medicine, University of Freiburg, Germany
    Br J Anaesth 86:176-82. 2001
    ..can change considerably between minimum and maximum lung volume, but is generally assumed to be constant in the tidal volume range (V(T))...
  60. ncbi Pulse pressure variations to predict fluid responsiveness: influence of tidal volume
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital of the Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 31:517-23. 2005
    To evaluate the influence of tidal volume on the capacity of pulse pressure variation (DeltaPP) to predict fluid responsiveness.
  61. ncbi Opioid-induced respiratory depression is associated with increased tidal volume variability
    T Bouillon
    University of Bonn, Department of Anaesthesia and Critical Care Medicine, Bonn, Germany
    Eur J Anaesthesiol 20:127-33. 2003
    ..The aim was to quantify opioid-induced irregularity of breathing and to investigate its time-course during and after an opioid infusion, and its ability to predict the severity of respiratory depression...
  62. ncbi Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 299:637-45. 2008
    ..Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality...
  63. ncbi Nonlinear measures of respiration: respiratory irregularity and increased chaos of respiration in patients with panic disorder
    Vikram Kumar Yeragani
    Department of Psychiatry, Wayne State University School of Medicine, Detroit, Mich, USA
    Neuropsychobiology 46:111-20. 2002
    ..In this study, we used these measures of respiration to compare normal controls (n = 18) and patients with panic disorder (n = 22) in addition to the traditional time domain measures of respiratory rate and tidal volume.
  64. ncbi Reduction of patient-ventilator asynchrony by reducing tidal volume during pressure-support ventilation
    Arnaud W Thille
    Henri Mondor Teaching Hospital, Paris XII University, Creteil, France
    Intensive Care Med 34:1477-86. 2008
    ..To identify ventilatory setting adjustments that improve patient-ventilator synchrony during pressure-support ventilation in ventilator-dependent patients by reducing ineffective triggering events without decreasing tolerance...
  65. ncbi Quantifying the roles of tidal volume and PEEP in the pathogenesis of ventilator-induced lung injury
    Adrian S Seah
    Department of Surgery, Fletcher Allen Health Care, Burlington, VT 05405, USA
    Ann Biomed Eng 39:1505-16. 2011
    ..this in mind, we mechanically ventilated naive, anesthetized, paralyzed mice for 4 h using either a low or high tidal volume (Vt) with either moderate or zero positive end-expiratory pressure (PEEP)...
  66. ncbi Effect of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits
    X Shen
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46223, USA
    J Appl Physiol (1985) 83:1202-8. 1997
    ..tidal volumes of 5, 10, and 20 ml/kg at a frequency of 15 breaths/min and also under static conditions (0 ml/kg tidal volume)...
  67. ncbi Preoxygenation: comparison of maximal breathing and tidal volume breathing techniques
    A S Baraka
    Department of Anesthesiology, American University of Beirut, Lebanon
    Anesthesiology 91:612-6. 1999
    Preoxygenation with tidal volume breathing for 3-5 min is recommended by Hamilton and Eastwood. This report compares tidal volume preoxygenation technique with deep breathing techniques for 30-60 s.
  68. pmc Low-tidal-volume ventilation in the acute respiratory distress syndrome
    Atul Malhotra
    Pulmonary and Critical Care Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 357:1113-20. 2007
  69. ncbi Alterations in peak inspiratory pressure and tidal volume delivered by manually operated self-inflating resuscitation bags as a function of the oxygen supply rate
    Armando Carlos Franco de Godoy
    Universidade Estadual de Campinas, Campinas, SP, Brasil
    J Bras Pneumol 34:817-21. 2008
    To assess possible alterations in the tidal volume and peak inspiratory pressure delivered by seven models of manually operated self-inflating resuscitation bags as a function of the oxygen supply rate used.
  70. ncbi High tidal volume as a predictor of acute lung injury in neurotrauma patients
    L Mascia
    Anesthesiology and Resuscitation Department, S Giovanni Battista Hospital, University of Turin, Turin, Italy
    Minerva Anestesiol 74:325-7. 2008
  71. ncbi An evaluation of peak inspiratory pressure, tidal volume, and ventilatory frequency during ventilation with a neonatal self-inflating bag resuscitator
    Mariana Almada Bassani
    Universidade Estadual de Campinas, Campinas, Sao Paulo, Brazil
    Respir Care 57:525-30. 2012
    ..The aims of this study were to assess possible sources of the high variability and to evaluate the adequacy of obtained values in relation to the recommended values for neonatal resuscitation...
  72. ncbi Influence of end-expiratory level and tidal volume on gravitational ventilation distribution during tidal breathing in healthy adults
    Silvia Schnidrig
    Division of Paediatric and Neonatal Intensive Care Medicine, Department of Paediatrics, Inselspital, University Children s Hospital and University of Bern, 3010 Bern, Switzerland
    Eur J Appl Physiol 113:591-8. 2013
    ..With increasing EEL but normal tidal volume, ventilation was preferentially distributed to the dependent lung and the filling of the right and left lung ..
  73. pmc SP-B and SP-C containing new synthetic surfactant for treatment of extremely immature lamb lung
    Atsuyasu Sato
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e39392. 2012
    ..Slight, but significant superiority of CHF5633 over Survanta was demonstrated in tidal volume at 20 min and dynamic lung compliance at 20 and 300 min...
  74. ncbi Association between estrus cycle-related aggression and tidal volume variability in female Wistar rats
    Lydia K Melchior
    Department of Pharmacology, Goteborg University, Goteborg, Sweden
    Psychoneuroendocrinology 29:1097-100. 2004
    ..The former group was found to display higher tidal volume variability in diestrus, as compared to the non-aggressive rats...
  75. ncbi Reliability of respiratory tidal volume estimation by means of ambulatory inductive plethysmography
    Paul Grossman
    Psychosomatic and Internal Medicine, University of Basel Hospital, Basel, Switzerland
    Biomed Sci Instrum 42:193-8. 2006
    ..g. respiration rate) and volumetric parameters (e.g. tidal volume and minute ventilation), by which tidal volume is initially calibrated to direct measures of volume...
  76. ncbi Ventilation with high tidal volume induces inflammatory lung injury
    P C S Bueno
    Laboratório de Pequenos Animais, Disciplina de Pneumologia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Braz J Med Biol Res 35:191-8. 2002
    ..This ventilatory strategy can affect the release of TNF-alpha in the lungs and can reach the systemic circulation, a finding that may have relevance for the development of a systemic inflammatory response...
  77. ncbi Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury
    Esther K Wolthuis
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Anesthesiology 108:46-54. 2008
    ..The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury...
  78. ncbi Tidal recruitment assessed by electrical impedance tomography and computed tomography in a porcine model of lung injury*
    Thomas Muders
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Crit Care Med 40:903-11. 2012
    ..To determine the validity of electrical impedance tomography to detect and quantify the amount of tidal recruitment caused by different positive end-expiratory pressure levels in a porcine acute lung injury model...
  79. ncbi Manual ventilation devices in neonatal resuscitation: tidal volume and positive pressure-provision
    Charles C Roehr
    Clinic of Neonatology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Resuscitation 81:202-5. 2010
    ..We compared the influence of different manual ventilation devices and individual professional experience on the extent of applied Vt and PIP in simulated neonatal resuscitation...
  80. ncbi Smoking and respiratory irregularity in panic disorder
    Daniela Caldirola
    Anxiety Disorder Clinical and Research Unit, S Raffaele Turro, Vita Salute University, Milan, Italy
    Biol Psychiatry 56:393-8. 2004
    ..The biological mechanisms underlying the link between smoking and panic attacks are unknown. Smoking might increase the risk of panic by impairing respiratory system function...
  81. ncbi Neurally adjusted ventilatory assist vs. pressure support ventilation in critically ill patients: an observational study
    J Barwing
    Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Gottingen Medical School, Germany
    Acta Anaesthesiol Scand 55:1261-71. 2011
    ..The purpose of our observational study was to transfer patients from conventional pressure support ventilation (PSV) to NAVA safely. We compared two approaches to set the NAVA level and evaluated the effect of NAVA...
  82. ncbi End-expiratory lung volume and ventilation distribution with different continuous positive airway pressure systems in volunteers
    B Andersson
    Department of Anesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden
    Acta Anaesthesiol Scand 55:157-64. 2011
    ..The aim of this study was to assess lung volume and ventilation distribution using three different CPAP techniques...
  83. pmc Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation
    Patrudu S Makena
    Dept of Medicine, Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Appl Physiol (1985) 111:1467-76. 2011
    Both prolonged exposure to hyperoxia and large tidal volume mechanical ventilation can each independently cause lung injury. However, the combined impact of these insults is poorly understood...
  84. pmc The air hunger response of four elite breath-hold divers
    Andrew P Binks
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, and Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA, USA
    Respir Physiol Neurobiol 159:171-7. 2007
    ..We tested the air hunger (AH) response of four divers who could hold their breath for 6-9 min. Tidal volume and respiratory rate were controlled by mechanical ventilation (ventilation approximately 0...
  85. ncbi The influence of endotracheal tube leak on the assessment of respiratory function in ventilated children
    E Main
    Physiotherapy Department, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1 N 3JH, UK
    Intensive Care Med 27:1788-97. 2001
    ..This study aimed to assess the influence of tracheal tube leak on measurements of C(rs), R(rs) and expired tidal volume (V(TE)) in ventilated children in order to establish when such measurements were reliable in this population.
  86. ncbi Low intraoperative tidal volume ventilation with minimal PEEP is associated with increased mortality
    M A Levin
    Department of Anesthesiology, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1010, New York, NY 10029, USA
    Br J Anaesth 113:97-108. 2014
    ..It is unclear whether the benefits of low TV ventilation can be extended into the perioperative period...
  87. ncbi High-frequency oscillatory ventilation versus conventional mechanical ventilation for very-low-birth-weight infants
    Sherry E Courtney
    Division of Neonatology, Cooper Hospital University Medical Center, Camden, NJ, USA
    N Engl J Med 347:643-52. 2002
    ..The efficacy and safety of early high-frequency oscillatory ventilation as compared with conventional synchronized intermittent mandatory ventilation for the treatment of infants with very low birth weight have not been established...
  88. ncbi Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1β proteins in pigs
    Vaclav Vobruba
    Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Exp Lung Res 39:1-8. 2013
    ..Group I: animals breathing spontaneously; group II: mechanical ventilation (tidal volume (TV) = 7 mL/kg, PEEP = 5 cmH(2)O); group III: mechanical ventilation (TV = 15 mL/kg, PEEP = 0 cmH(2)0)...
  89. ncbi Efficacy of preoxygenation using tidal volume and deep breathing techniques with and without prior maximal exhalation
    Usharani Nimmagadda
    Department of Anesthesiology, Advocate Illinois Masonic Medical Center, 836 W Wellington Avenue, Chicago, IL 60657, USA
    Can J Anaesth 54:448-52. 2007
    We evaluated the influence of prior maximal exhalation on preoxygenation in 15 adult volunteers using tidal volume breathing (TVB) for five minutes and deep breathing (DB) for two minutes with and without prior maximal exhalation.
  90. ncbi Is there an optimal breath pattern to minimize stress and strain during mechanical ventilation?
    Josef X Brunner
    Centre Suisse d Electronique et de Microtechnique, Schulstrasse 1, 7302 Landquart, Switzerland
    Intensive Care Med 35:1479-83. 2009
    Inappropriate selection of tidal volume and rate on mechanical ventilators in patients with reduced lung volume may cause lung damage...
  91. ncbi An audible indication of exhalation increases delivered tidal volume during bag valve mask ventilation of a patient simulator
    Samsun Lampotang
    Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida, USA
    Anesth Analg 102:168-71. 2006
    ..The last three breaths in each set were used to compare average tidal volume (Vt) under both conditions...
  92. ncbi Preoxygenation with tidal volume and deep breathing techniques: the impact of duration of breathing and fresh gas flow
    U Nimmagadda
    Department of Anesthesiology, Illinois Masonic Medical Center, 836 W. Wellington Avenue, Chicago, IL 60657, USA
    Anesth Analg 92:1337-41. 2001
    Various techniques of "preoxygenation" before anesthetic induction have been advocated, including tidal volume breathing (TVB) for 3-5 min, four deep breaths (DB) in 0.5 min, and eight DB in 1 min...
  93. ncbi Effect of perfluorocarbon (perfluorooctyl bromide) vapor on tidal volume measurement during partial liquid ventilation
    Mark W Davies
    Grantley Stable Neonatal Unit, Royal Women s Hospital, Brisbane, Queensland, Australia
    Crit Care Med 30:1123-5. 2002
    ..We also aimed to determine the correction factor needed to calculate tidal volumes measured in the presence of perfluorooctyl bromide vapor...
  94. ncbi Four methods of measuring tidal volume during high-frequency oscillatory ventilation
    David N Hager
    Division of Pulmonary and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Crit Care Med 34:751-7. 2006
    Assess the accuracy of four different methods of measuring tidal volume during simulated high-frequency oscillatory ventilation.
  95. ncbi Cardiovascular and pulmonary consequences of airway recruitment in preterm lambs
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, M094, 35 Stirling Highway, Crawley, 6009, Western Australia, Australia
    J Appl Physiol (1985) 106:1347-55. 2009
    ..Preterm lambs (129 +/- 1 days) were ventilated initially with a tidal volume of 7 ml/kg and 4 cmH(2)O of PEEP...
  96. ncbi Abdominal volume contribution to tidal volume as an early indicator of respiratory impairment in Duchenne muscular dystrophy
    A Lo Mauro
    TBM Lab, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy
    Eur Respir J 35:1118-25. 2010
    ..In the supine position, the average contribution of abdominal volume change (DeltaV(AB)) to tidal volume progressively decreased with age (p<0.001)...
  97. ncbi Effects of gender and posture on thoraco-abdominal kinematics during quiet breathing in healthy adults
    M Romei
    IRCCS E Medea, Bosisio Parini LC, Italy
    Respir Physiol Neurobiol 172:184-91. 2010
    ..progressively increased inclination of the trunk determined a progressive reduction of rib cage displacement, tidal volume, and minute ventilation and a progressive increase of abdominal contribution to tidal volume...
  98. ncbi Genomics made functional in ventilator-associated lung injury
    Jeffrey R Jacobson
    Am J Respir Crit Care Med 168:1023-5. 2003
  99. pmc Tidal volume, cardiac output and functional residual capacity determine end-tidal CO2 transient during standing up in humans
    Janneke Gisolf
    Department of Physiology, Academic Medical Center, Cardiovascular Research Institute, Amsterdam, The Netherlands
    J Physiol 554:579-90. 2004
    ..To study the contribution of an increase in tidal volume (V(T)) and breathing frequency, a decrease in stroke volume (SV), a ventilation-perfusion (V/Q) gradient and an ..
  100. ncbi Respiratory motor recovery after unilateral spinal cord injury: eliminating crossed phrenic activity decreases tidal volume and increases contralateral respiratory motor output
    Francis J Golder
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Neurosci 23:2494-501. 2003
    ..To determine whether crossed phrenic pathways contribute to tidal volume in spinally injured rats, spontaneous breathing was measured in anesthetized C2 hemisected rats at 2 months ..
  101. ncbi When a leak is unavoidable, preoxygenation is equally ineffective with vital capacity or tidal volume breathing
    Caroline Gagnon
    Department of Anesthesiology, Maisonneuve Rosemont Hospital, 5415 l Assomption Blvd, Montreal, Quebec H1T 2M4, Canada
    Can J Anaesth 53:86-91. 2006
    ..5 to one minute, but in practice leaks are frequent and sometimes unavoidable. This study was designed to determine which breathing method provided the best oxygenation in the presence of leak...

Research Grants62

  1. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..ECG, we extract heart rate variability (HRV) and ECG R-wave amplitude fluctuations associated with respiratory tidal volume changes (the ECG-derived respiration, EDR)...
  2. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..the pharmacodynamic (PD) profile of R-503 in a rat model of VILI Sprague-Dawley rats will be subjected to high tidal volume (TV) MV with positive end expiratory pressure (PEEP) of 3 cm H2O...
  3. Pharmacological strategies to improve breathing after cervical spinal cord injury
    FRANCIS GOLDER; Fiscal Year: 2009
    ..Phrenic motor output is positively correlated to tidal volume;therefore, increasing phrenic motoneuron activity can improve tidal volume after SCI...
  4. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2013
    ..present grant proposal examines the overarching hypothesis that, by promoting uniform parenchymal aeration and tidal volume distribution throughout the lung, prone positioning leads to a reduction of neutrophil metabolic activation ..
  5. The Role of Xanthine Oxidoreductase in Ventilator-Associated Lung Injury
    Paul M Hassoun; Fiscal Year: 2013
    ..form the basis of this application renewal, we now demonstrate that mechanical stress, in the context of high tidal volume ventilation, leads to profound re-arrangement of the pulmonary endothelial cytoskeleton, apoptosis, and ..
  6. Prediction of Physiological Events in People with Sleep Disordered Breathing
    Jonathan A Waxman; Fiscal Year: 2011
    ..People with OSA experience repetitive apnea (cessation of breathing) and hypopnea (marked decrease in tidal volume) during sleep in association with airway compromise and excessive daytime sleepiness (EDS)...
  7. Regulation and function of Cyr61 in hyperoxia induced acute lung injury
    Yang Jin; Fiscal Year: 2010
    ..is still poorly understood and therapeutic options remain limited despite the recent progress in protective low tidal volume ventilatory strategies...
  8. Prognostic &Therapeutic Implications of Breathing Patterns in Acute Lung Injury
    FRANK JOSEPH JACONO; Fiscal Year: 2013
    ..Well established and validated rodent models of lung injury (bleomycin-instillation and high tidal volume ventilation) will be used...
  9. Role of NOS2 in Sepsis-Induced ARDS
    Rebecca M Baron; Fiscal Year: 2013
    ..mice will be subjected to cecal-ligation and puncture (CLP) and antibiotic treatment, followed by low tidal volume mechanical ventilation...
  10. MAP Kinase Signaling in Apoptosis-Induced Ventilator-Associated Lung Injury
    Mahendra Damarla; Fiscal Year: 2013
    ..Low tidal volume lung strategies remain the only supportive treatment of ALI/VALI with proven efficacy...
  11. Actuated, Low-Stress, Endotracheal Tube Cleaner to Improve Neonate Lung Function
    ROGER BROOKS BAGWELL; Fiscal Year: 2013
    ..I Hypotheses: Pedi ET-Clear Alpha prototype demonstrates superior safety (e 50% improvement in retained lung tidal volume) and superior efficacy (cleaner ETT in the same amount of time) compared to standard suction catheter in 2...
  12. Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury (CITRIS-ALI)
    Jonathon D Truwit; Fiscal Year: 2013
    ..Only low tidal volume "lung-protective" ventilation and conservative fluid management strategies show a mortality benefit...
  13. XOR Regulation of Endothelial Cell Apoptosis in the Model of VALI
    BO SOO KIM; Fiscal Year: 2010
    ..Previous animal model studies have demonstrated that high tidal volume (HVT 20 ml/kg) ventilation concomitantly activates the enzyme xanthine oxidoreductase (XOR) and promotes ..
  14. Regulatory Tcells and the fibroproliferative response in Acute Lung Injury
    Brian Garibaldi; Fiscal Year: 2011
    ..underlying the development of ARDS, mortality remains high and the only treatment shown to be effective is low tidal volume ventilation in patients who require ventilatory support...
  15. IN VIVO FUNCTION OF PULMONARY INTEGRINS
    Dean Sheppard; Fiscal Year: 2013
    ..of this pathway in a more clinically relevant model of acute lung injury that combines low dose LPS with normal tidal volume ventilation...
  16. p38MAP kinase-dependent mechanisms of fever-enhanced acute lung injury
    Paul S Shapiro; Fiscal Year: 2013
    ..Despite the general acceptance of low tidal volume ventilation for support of patients with ALI, mortality in such patients remains ~40%...
  17. RESOLUTION OF CLINICAL LUNG INJURY
    Michael A Matthay; Fiscal Year: 2013
    ..epithelial fluid clearance in order to test the effect of clinically relevant therapeutic strategies (very low tidal volume (3 ml/kg), high frequency ventilation, dopamine, interleukin-1 receptor antagonist, and growth factors) on lung ..
  18. Metabolite effects on Group III and IV afferents
    MARC PETER KAUFMAN; Fiscal Year: 2013
    ..discharge to the vasculature, decreases in vagal discharge to the heart and airways as well as increases in tidal volume and breathing frequency...
  19. The Role of Cyclooxygenase 2 in Mechanical Stress-Induced Lung Injury
    Stephanie A Nonas; Fiscal Year: 2013
    ..of C0X2 associated with increased lung inflammation and vascular barrier disruption in response to high tidal volume mechanical ventilation...
  20. Role of mTORC1 in ventilator induced lung injury
    Joshua A Englert; Fiscal Year: 2013
    ..Limiting lung stretch in patients by using low tidal volume ventilation is one of th few strategies that has been shown to decrease mortality in patients with ARDS...
  21. Remote and non-invasive continuous cardiopulmonary monitoring using low-power FM
    KIRILL S contact MOSTOV; Fiscal Year: 2010
    ..in the following four physiological variables: heart rate, respiratory rate, cardiac output and respiratory tidal volume. MFMR aims to enable continuous monitoring of these variables remotely, non-invasively and with no health risks ..
  22. Neonatal Resuscitation and Preterm Lung Injury
    Alan H Jobe; Fiscal Year: 2010
    ..project to perform a factorial assessment of the components of neonatal resuscitation (stretch from high tidal volume and no positive end expiratory pressure, 100% O2, and cold/dry gas) that are likely to injure the preterm lung...
  23. Lung Injury with Resuscitation of the Preterm
    Noah H Hillman; Fiscal Year: 2013
    ..in ventilator induced lung injury, 2)Role of IL-1 in resuscitation induced lung injury, and 3)Role of PEEP and tidal volume on resuscitation induced lung injury. The research will be conducted under the supervision of Drs...
  24. Respiratory Mechanics in Lung Disease and Surgery
    Stephen H Loring; Fiscal Year: 2010
    ..end-inflation or too low at end-exhalation (ee) can result in ventilator-induced lung injury (VILI), even when tidal volume is limited. To avoid VILI, clinicians limit tidal volume and monitor Pao as an index of lung expansion...
  25. PBEF Neutralizing Humanized Monoclonal Antibodies As Novel Therapeutic Approaches
    Joe G N Garcia; Fiscal Year: 2012
    ..Currently, the only remedial procedure in place is the use of low tidal volume ventilation, a practice not universally embraced and insufficient to completely prevent VILI...
  26. Positron Emission Tomography for Radiation Therapy
    Daniel A Low; Fiscal Year: 2010
    ..systems and a quantitative 5-dimensional (5D) model of breathing motion as a function of breathing air volume (tidal volume) and the rate of breathing (airflow)...
  27. Disposable Respiratory Flow Measurement Device
    BENJAMIN R LANE; Fiscal Year: 2010
    ..Current technologies lack the ability to accurately measure tidal volume but rather provide a semi-quantitative measure of respiratory patterns...
  28. EPVent 2-A Phase II Trial Esophageal Pressure Guided Ventilation
    DANIEL STUART TALMOR; Fiscal Year: 2013
    ..Low tidal volume ventilation strategies are clearly beneficial in patients with ALI/ARDS...
  29. SURGICAL STUDIES OF SEVERE RESPIRATORY FAILURE
    Joseph Zwischenberger; Fiscal Year: 2004
    ..From our animal and initial patient safety trials, AVCO2R allows decreased respiratory rate, tidal volume, and peak airway pressures such that PIP is predictably less than 30 cm H20 and respiratory rate 4 about ..
  30. A novel implementation and social network strategy for acute pulmonary illnesses
    Curtis H Weiss; Fiscal Year: 2013
    ..intervention comprised of opinion leader learning collaboratives, electronic alerts and reminders, and audit and feedback increases implementation rates of low tidal volume ventilation and ABC weaning compared to usual care.
  31. Targeting Membrane Repair in Deformation-Induced Lung Injury
    Xiaoli Zhao; Fiscal Year: 2013
    ..of the lung epithelial cells during mechanical ventilation when the lung is inflated beyond its normal tidal volume. We have shown previously that wounding of alveolar cells plays an important role in the development of VALI ..
  32. EFFECTS OF ANESTHESIA AND LOADING ON RESPIRATION
    ENID KAFER; Fiscal Year: 1980
    ..The studies will measure the tidal volume, airway pressure, respiratory timing, and neural reflex responses to single breath and to continuous ..
  33. PHRENIC NERVE PACING: NONINVASIVE DIAPHRAGM ANALYSIS
    Sidney Levitsky; Fiscal Year: 1980
    ..diaphragmatic surface to directly measure its mechanical activity so that indirect quantitative measurements of tidal volume, air flow and overall pulmonary function can be performed...
  34. Optimizing Ventilation Distribution in Injured Lung Using Computational Modeling
    Reza Amini; Fiscal Year: 2013
    ..We will select varying conditions of positive end expiratory pressure (PEEP), tidal volume (VT), and respiratory rate while determining acinar flow and pressure distributions through the lung...
  35. METALLOPROTEINASES IN VENTILATOR-INDUCED LUNG INJURY
    Hussein Foda; Fiscal Year: 2003
    ..The NIH NHLBI ARDS clinical trials network has just reported that MV strategies employing low tidal volume ventilation reduced mortality in ARDS by 25 percent and lead to a decrease in lung injury and multisystem organ ..
  36. Ventilation Improves Lung Physiology and Biology
    Bela Suki; Fiscal Year: 2006
    ..Recently, we have reported that during MV, variability added to tidal volume (Vt) and frequency on a cycle by cycle basis, called variable ventilation(VV), improves both lung mechanics and ..
  37. Automated retraction for thoracotomy: Improved recovery of respiratory function a
    HUGH CRENSHAW; Fiscal Year: 2009
    ..Primary endpoints will be reduced frequency of rib fracture, faster recovery of respiratory function (tidal volume), and faster recovery from pain (behavioral measures)...
  38. RESPIRATORY CONSEQUENCES OF OPIATES
    TEODORO SANTIAGO; Fiscal Year: 1992
    ..Manifestations of this modulation include depression of tidal volume and CO2 chemosensitivity during acute flow-resistive loading in goats, and loss of flow-resistive load ..
  39. Psychobiology of IV Naloxone & Lactate in Normals
    Donald Klein; Fiscal Year: 2005
    ..The panic attack is distinctively characterized by acute dyspnea, tidal volume hyperventilation and surprising lack of HPA activation...
  40. ALTERATIONS IN RESPIRATORY SYSTEM MECHANICS WITH PLEURAL
    Willane Krell; Fiscal Year: 1991
    ..of the RS to the load produced by effusion, effective elastance will be determined from RS pressures and tidal volume behavior in the four states studied...
  41. PAL: Pre-Clinical Fabrication & Outcomes Studies
    Joseph Zwischenberger; Fiscal Year: 2004
    ..outcomes and measure injury parameters in two prospective randomized groups (N=10) over 10 days: 1) low tidal volume (LTV) ventilator management versus 2) PAL...
  42. BEHAVIORAL AND RESPIRATORY EFFECTS OF METHYLXANTHINES
    Leonard Howell; Fiscal Year: 1993
    ..Ventilation (minute volume, tidal volume and respiratory frequency) in unanesthetized rhesus monkeys will be continuously monitored and measured by ..
  43. TOTAL LIQUID VENTILATION: A BIOENGINEERING PARTNERSHIP
    Ronald Hirschl; Fiscal Year: 2003
    ..Secondly, we intend to investigate and to model the parameters which affect gas exchange during TLV, such as tidal volume, respiratory rate, and lung distension, and to model local flow patterns within the airways and alveoli...
  44. BREATH-BY-BREATH NON-INVASIVE CARDIAC OUTPUT MONITOR
    JERRY CALKINS; Fiscal Year: 2000
    ..A lightweight, rugged device would be ideally suited for use in field environments such as the ambulance and MEDEVAC transport, as well as the doctor's office, clinic, the ER and ICU. ..
  45. GAS PHASE DIFFUSION LIMITATIONS IN THE LUNG
    GILBERT BERDINE; Fiscal Year: 1990
    This project will study several aspects of low tidal volume (20-100 ml) high frequency (4-40 Hz) ventilation (HFV)...
  46. PSYCHOBIOLOGY AND TEMPERAMENT IN HIGH RISK CHILDREN
    Janet Fairbanks; Fiscal Year: 2002
    ..Measures of respiratory function include end-tidal carbon dioxide, respiratory rate, tidal volume, and minute ventilation. These have been implicated in behavioral inhibition and anxiety disorders...
  47. Oxidative Inflammatory Mechanisms of Hypercapnia
    John Lang; Fiscal Year: 2007
    ..Recent innovative clinical strategies for resolving this pathologic process include the use of "protective" low tidal volume ventilatory strategies to retard ventilator-associated lung injury (VALI)...
  48. COMPUTERIZED PHYSIOLOGICAL DATA SYSTEM
    SUE HEGYVARY; Fiscal Year: 1991
    ..Blood Pressure Recording System to measure continuous blood pressure; the Respisomnograph System to measure tidal volume and other respiratory parameters during sleep; and the Biofeedback System to train individuals to cognitively ..
  49. Evaluation of a new technique for Manual Ventilation
    Richard Henderson; Fiscal Year: 2005
    ..A new Dual-Control Manual Resuscitator (DCMR) device has been developed that adds tidal volume and inspiratory pressure controls to the current manual resuscitator design...
  50. AuContrAer:Ventilator Compatible Aerosol Delivery Device
    Richard Parker; Fiscal Year: 2002
    ..in the lung by varying the timing and duration of nebulization during the breathing cycle, the ventilator tidal volume during nebulization, and the aerosol particle size. 2...
  51. Sleep in PTSD/Panic: A Multimodal Naturalistic Study
    Javaid Sheikh; Fiscal Year: 2006
    ..these two anxiety disorders appear to exhibit divergent modifications of nocturnal respiration, elevated tidal volume variability in PD, versus accelerated respiration in association with nightmares in PTSD...
  52. AIRWAY PERFUSION ASSISTED LIQUID VENTILATOR
    James Parker; Fiscal Year: 1999
    ..intratracheal circulation of PFC liquid through a double lumen catheter with superimposed delivery of liquid tidal volume removes airway dead space ventilation and facilitates respiratory gas diffusion through airway eddy currents...
  53. FRACTIONAL UPTAKE (CO) AS AN INDICATOR OF PCP PNEUMONIA
    BRIAN CRAINE; Fiscal Year: 1992
    ..During the Phase I of this study, the investigators will demonstrate that FU(CO) measurements are reproducible and determine the magnitude of the effect of physiological parameters (such as tidal volume) on the FU(CO) measurement.
  54. DYNAMIC AIRWAY BEHAVIOR
    Stephen Loring; Fiscal Year: 1980
    ..Breathing pattern will be changed by altering tidal volume, respiratory frequency and mean lung volume in artificially ventilated animals...
  55. INHALED NITRIC OXIDE
    Warren Zapol; Fiscal Year: 2007
    ..Studies proposed in the first three acute lung injury due to endotoxemia and high tidal volume ventilation...
  56. Advanced at-Home Screening Device for Sleep Apnea
    ARTHUR COOKE; Fiscal Year: 2002
    ..In addition, the sensor captures far more acoustic information than just quantitative tidal volume and qualitative flow patterns, and hence can be used to characterize obstruction, respiratory effort, etc...
  57. CENTER FOR CLINICAL NETWORK FOR ARDS TREATMENT
    David Schoenfeld; Fiscal Year: 2000
    ..Studies in progess are: The Late Steroid Rescue Study; Assessment of Low Tidal Volume and Elevated End-Expiratory Volume to Obviate Lung Injury, and The Pulmonary Artery Catheter/Fluid Management ..
  58. OPIOID DEPRESSION OF RESPIRATORY NEURONS
    PETER LALLEY; Fiscal Year: 2003
    ..It will also test a new method that may alleviate opioid-induced depression of respiration without affecting analgesia, and counteract respiratory depression by overdose of opioids. ..
  59. CSF AND THE CENTRAL CHEMICAL CONTROL OF BREATHING
    Eugene Nattie; Fiscal Year: 2008
    ..abstract_text> ..
  60. High Frequency Oscillatory Ventilation in ARDS
    David Hager; Fiscal Year: 2005
    ..abstract_text> ..
  61. MECHANICS OF ACUTE LUNG INJURY
    Jason Bates; Fiscal Year: 2009
    ..The results of our studies are expected to lead to the design of physiologically-based lung recruitment strategies that can be tailored to the individual patient with ALI. This will set the stage for future clinical trials. ..