vital capacity

Summary

Summary: The volume of air that is exhaled by a maximal expiration following a maximal inspiration.

Top Publications

  1. ncbi Standardisation of spirometry
    M R Miller
    University Hospital Birmingham NHS Trust, Birmingham, UK
    Eur Respir J 26:319-38. 2005
  2. ncbi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
  3. pmc Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
    W Q Gan
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, British Columbia, Canada V6A 1Y6
    Thorax 59:574-80. 2004
  4. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
  5. ncbi New reference values for forced spirometry in white adults in Brazil
    Carlos Alberto de Castro Pereira
    Service of Pulmonology Department, Hospital do Servidor Publico Estadual, HSPE, Sao Paulo, SP, Brazil
    J Bras Pneumol 33:397-406. 2007
  6. pmc Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
    Dana B Hancock
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Nat Genet 42:45-52. 2010
  7. ncbi Forced vital capacity, airway obstruction and survival in a general population sample from the USA
    P G J Burney
    National Heart Lung Institute, Imperial College, London, UK
    Thorax 66:49-54. 2011
  8. ncbi Prevalence, severity and underdiagnosis of COPD in the primary care setting
    M Bednarek
    2nd Department of Respiratory Medicine, National Research Institute of Tuberculosis and Lung Diseases, 26 Plocka St, Warsaw 01 138, Poland
    Thorax 63:402-7. 2008
  9. ncbi Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease. The Lung Health Study
    P D Scanlon
    Division of Pulmonary and Critical Care Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 161:381-90. 2000
  10. pmc Impairment of pulmonary function is an independent risk factor for atrial fibrillation: the Takahata study
    Yoko Shibata
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Int J Med Sci 8:514-22. 2011

Research Grants

  1. Phase II/III Study of Arimoclomol in the Treatment of SOD1 Positive Familial?.
    Merit E Cudkowicz; Fiscal Year: 2013
  2. MOCSLID-DCC
    Robert M Elashoff; Fiscal Year: 2012
  3. Panic-Relevant Sensations and Smoking Motivation
    SAMANTHA GWEN FARRIS; Fiscal Year: 2013
  4. Rituximab Therapy in Patients with IPF
    KEVIN FITZGERALD GIBSON; Fiscal Year: 2013
  5. Pilot Placebo-Controlled Trial of Early Noninvasive Ventilation for ALS
    Kirsten L Gruis; Fiscal Year: 2011
  6. MOCSLID-CCC
    Donald P Tashkin; Fiscal Year: 2012
  7. Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)
    Anne B Newman; Fiscal Year: 2010
  8. Quantitative Magnetic Resonance Imaging of Biofilm in Cystic Fibrosis
    Rebecca J Theilmann; Fiscal Year: 2013
  9. Passive stretch of the chest wall in patients with Congential Muscular Dystrophy
    Raouf S Amin; Fiscal Year: 2013
  10. Treatment of IPF with Laparoscopic Anti-reflux Surgery
    Ganesh Raghu; Fiscal Year: 2013

Detail Information

Publications334 found, 100 shown here

  1. ncbi Standardisation of spirometry
    M R Miller
    University Hospital Birmingham NHS Trust, Birmingham, UK
    Eur Respir J 26:319-38. 2005
  2. ncbi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  3. pmc Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
    W Q Gan
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, British Columbia, Canada V6A 1Y6
    Thorax 59:574-80. 2004
    ..Systemic inflammation may be involved in the pathogenesis of these disorders. A study was undertaken to determine whether systemic inflammation is present in stable COPD...
  4. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
    ..tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry)...
  5. ncbi New reference values for forced spirometry in white adults in Brazil
    Carlos Alberto de Castro Pereira
    Service of Pulmonology Department, Hospital do Servidor Publico Estadual, HSPE, Sao Paulo, SP, Brazil
    J Bras Pneumol 33:397-406. 2007
    ..To describe spirometric reference equations for healthy Brazilian adults who have never smoked and to compare the predicted values with those derived in 1992...
  6. pmc Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
    Dana B Hancock
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Nat Genet 42:45-52. 2010
    ..lung-function measures: forced expiratory volume in the first second (FEV(1)) and its ratio to forced vital capacity (FEV(1)/FVC), an indicator of airflow obstruction...
  7. ncbi Forced vital capacity, airway obstruction and survival in a general population sample from the USA
    P G J Burney
    National Heart Lung Institute, Imperial College, London, UK
    Thorax 66:49-54. 2011
    ..However, the observation that vital capacity is also associated with survival weakens this interpretation.
  8. ncbi Prevalence, severity and underdiagnosis of COPD in the primary care setting
    M Bednarek
    2nd Department of Respiratory Medicine, National Research Institute of Tuberculosis and Lung Diseases, 26 Plocka St, Warsaw 01 138, Poland
    Thorax 63:402-7. 2008
    ..Chronic obstructive pulmonary disease (COPD) is a common disease with a steadily increasing prevalence and mortality. However, recent epidemiological estimates differ depending on the population studied and methods used...
  9. ncbi Smoking cessation and lung function in mild-to-moderate chronic obstructive pulmonary disease. The Lung Health Study
    P D Scanlon
    Division of Pulmonary and Critical Care Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 161:381-90. 2000
    ..Respiratory symptoms were not predictive of changes in lung function. Smokers with airflow obstruction benefit from quitting despite previous heavy smoking, advanced age, poor baseline lung function, or airway hyperresponsiveness...
  10. pmc Impairment of pulmonary function is an independent risk factor for atrial fibrillation: the Takahata study
    Yoko Shibata
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
    Int J Med Sci 8:514-22. 2011
    ..The relationship between the prevalence of AF and pulmonary function is unclear. The aim of this study was to evaluate this relationship in participants in a health check...
  11. ncbi The effects of body mass index on lung volumes
    Richard L Jones
    Pulmonary Division, University of Alberta, Edmonton, AB, Canada T6G 2B7
    Chest 130:827-33. 2006
    ..It is well known that obesity causes decreases in lung volumes, but there has never been a large study showing the correlation between body mass index (BMI) and the various lung volumes...
  12. pmc A genome-wide association study of pulmonary function measures in the Framingham Heart Study
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    PLoS Genet 5:e1000429. 2009
    The ratio of forced expiratory volume in one second to forced vital capacity (FEV(1)/FVC) is a measure used to diagnose airflow obstruction and is highly heritable...
  13. ncbi Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis
    Arata Azuma
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Am J Respir Crit Care Med 171:1040-7. 2005
    ..In conclusion, treatment with pirfenidone improved VC and prevented acute exacerbation of IPF during the 9 months of follow-up. Future long-term studies are needed to clarify the overall safety and efficacy of pirfenidone in IPF...
  14. ncbi Pulmonary function and abdominal adiposity in the general population
    Heather M Ochs-Balcom
    INFORMA, National Cancer Institute Regina Elena, Rome, Via Elio Chianesi 53, 00144 Rome, Italy
    Chest 129:853-62. 2006
    ..The mechanism for this association and the best marker of abdominal adiposity in relation to pulmonary function is not known...
  15. ncbi Screening for and early detection of chronic obstructive pulmonary disease
    Joan B Soriano
    CIMERA International Center for Advanced Respiratory Medicine, Recinte Hospital Joan March, Bunyola, Spain
    Lancet 374:721-32. 2009
    ..All in all, spirometry is recognised as the essential test for diagnosis and monitoring of COPD...
  16. ncbi Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial
    Talmadge E King
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0120, USA
    Lancet 374:222-8. 2009
    ..We assessed whether treatment with interferon gamma-1b improved survival compared with placebo in patients with idiopathic pulmonary fibrosis and mild-to-moderate impairment of pulmonary function...
  17. ncbi Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis
    E K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 157:1770-8. 1998
    ..The increased risk to relatives of early-onset COPD probands for reduced FEV1 and chronic bronchitis, limited to current or ex-smokers, suggests genetic risk factor(s) for COPD that are expressed in response to cigarette smoking...
  18. ncbi Regional tidal ventilation and compliance during a stepwise vital capacity manoeuvre
    Peter A Dargaville
    Department of Paediatrics, Royal Hobart Hospital and University of Tasmania, Liverpool Street, Hobart, TAS, 7000, Australia
    Intensive Care Med 36:1953-61. 2010
    ..To determine whether, during mechanical ventilation, an optimal positive end-expiratory pressure (PEEP) can be identified by measurement of regional tidal volume and compliance [V (T(reg)), C (RS(reg))]...
  19. ncbi Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1/vital capacity ratio: a longitudinal population study from childhood to adulthood
    Finn Rasmussen
    Firestone Institute for Respiratory Health, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 165:1480-8. 2002
    ..A low postbronchodilator ratio of forced exhaled volume in 1 second (FEV1) to vital capacity (VC) at age 18 or 26 was used as a marker of airway remodeling...
  20. ncbi Relationship between habit of cigarette smoking and airflow limitation in healthy Japanese individuals: the Takahata study
    Daisuke Osaka
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
    Intern Med 49:1489-99. 2010
    ..9% (16.4% of males and 5.0% of females). Cigarette smoking is well known as a major cause of COPD. However, few epidemiological studies have evaluated the effects of cigarette smoking on pulmonary function in healthy subjects...
  21. ncbi Waist circumference is associated with pulmonary function in normal-weight, overweight, and obese subjects
    Yue Chen
    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada
    Am J Clin Nutr 85:35-9. 2007
    ..Because both weight and height are indicators of body size, body mass index (BMI) may not be an ideal index of obesity in prediction of pulmonary dysfunction...
  22. pmc Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness
    L M Schachter
    Institute of Respiratory Medicine, University of Sydney, Sydney, NSW 2006, Australia
    Thorax 56:4-8. 2001
    ....
  23. ncbi Forced vital capacity in patients with idiopathic pulmonary fibrosis: test properties and minimal clinically important difference
    Roland M du Bois
    Imperial College, London, UK
    Am J Respir Crit Care Med 184:1382-9. 2011
    Forced vital capacity (FVC) is an established measure of pulmonary function in idiopathic pulmonary fibrosis (IPF)...
  24. pmc Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease
    J J Soler-Cataluña
    Unidad de Neumología, Servicio de Medicina Interna, Hospital General de Requena, Paraje Casablanca s n 46340, Requena Valencia, Spain
    Thorax 60:925-31. 2005
    ..However, little is known about the prognostic consequences of these exacerbations. A study was undertaken to investigate whether severe acute exacerbations of COPD exert a direct effect on mortality...
  25. pmc Sustained effects of integrated COPD management on health status and exercise capacity in primary care patients
    Annemarije L Kruis
    Department of Public Health and Primary Care, Leiden University Medical Center, Leiden
    Int J Chron Obstruct Pulmon Dis 5:407-13. 2010
    ..Integrated disease management (IDM) of mild to moderate COPD patients has been demonstrated to improve exercise capacity and health status after one year, but long-term results are currently lacking in primary care...
  26. ncbi Conditions associated with an abnormal nonspecific pattern of pulmonary function tests
    Robert E Hyatt
    Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Chest 135:419-24. 2009
    ..We term this a nonspecific pattern (NSP). We sought to identify medical conditions having this pattern and to explore mechanisms producing it...
  27. pmc Comparison of spirometry criteria for the diagnosis of COPD: results from the BOLD study
    W M Vollmer
    Kaiser Permanente, Center for Health Research, Portland, OR 97227 1110, USA
    Eur Respir J 34:588-97. 2009
    ..Use of the lower limit of normal (LLN) forced expiratory volume in 1 s (FEV(1)) to forced vital capacity (FVC) ratio reduced the age-related increases in COPD prevalence that are seen among healthy never-smokers ..
  28. ncbi [Spirometric reference values in 5 large Latin American cities for subjects aged 40 years or over]
    Rogelio Perez-Padilla
    Instituto Nacional de Enfermedades Respiratorias México DF México
    Arch Bronconeumol 42:317-25. 2006
    ..The aim of this study was to report spirometric reference values for 5 cities in Latin America...
  29. ncbi Respiratory effects of exposure to diesel traffic in persons with asthma
    James McCreanor
    National Heart and Lung Institute, Imperial College, and Royal Brompton Hospital, London, United Kingdom
    N Engl J Med 357:2348-58. 2007
    ..We investigated the effects of short-term exposure to diesel traffic in people with asthma in an urban, roadside environment...
  30. ncbi Prediction equations for normal and low lung function from the Health Survey for England
    E Falaschetti
    Dept of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Eur Respir J 23:456-63. 2004
    ..The measurements used were the forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) of a sample of 6,053 "healthy" (nonsmokers with no reported diagnosis of asthma or respiratory symptoms) ..
  31. pmc Systemic inflammation in young adults is associated with abnormal lung function in middle age
    Ravi Kalhan
    Asthma Chronic Obstructive Pulmonary Disease Program, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e11431. 2010
    ..Whether systemic inflammation in healthy young adults is associated with future impairment in lung health is uncertain...
  32. ncbi Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers
    S Salvi
    University Medicine Department, Southampton General Hospital, Southampton, and Cardiovascular Research, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    Am J Respir Crit Care Med 159:702-9. 1999
    ....
  33. pmc Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD
    R A O'Donnell
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation and Repair, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Thorax 59:837-42. 2004
    ..A number of research tools have been combined to study smokers with a range of COPD severities classified according to the GOLD criteria...
  34. pmc Air pollution and lung function in the European Community Respiratory Health Survey
    Thomas Gotschi
    Department of Preventive Medicine, University of Southern California, Los Angeles, USA
    Int J Epidemiol 37:1349-58. 2008
    ..The aim of this study was to determine the association between long-term urban background air pollution and lung function levels, as well as change in lung function among European adults...
  35. ncbi Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis
    Luca Richeldi
    Center for Rare Lung Diseases, University of Modena and Reggio Emilia, Policlinico Hospital, Via del Pozzo 71, 41100 Modena, Italy
    Thorax 67:407-11. 2012
    Decline in forced vital capacity (FVC) over time reliably predicts mortality in patients with idiopathic pulmonary fibrosis. The use of this measure in clinical practice is recommended by current evidence-based guidelines...
  36. pmc "GOLD or lower limit of normal definition? A comparison with expert-based diagnosis of chronic obstructive pulmonary disease in a prospective cohort-study"
    Gülmisal Güder
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Respir Res 13:13. 2012
    ..GOLD) defines COPD as a fixed post-bronchodilator ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC) below 0.7...
  37. pmc Vitamin D deficiency, smoking, and lung function in the Normative Aging Study
    Nancy E Lange
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 186:616-21. 2012
    ..Vitamin D has immunomodulatory and antiinflammatory effects that may be modified by cigarette smoke and may affect lung function...
  38. ncbi Dependence of maximal flow-volume curves on time course of preceding inspiration
    E Prandi
    Istituto di Fisiologia Umana I, , Italy
    J Appl Physiol 75:1155-9. 1993
    ..normal subjects, sitting in a body plethysmograph and breathing through a pneumotachograph, performed forced vital capacity maneuvers after a rapid inspiration without or with an end-inspiratory pause (maneuvers 1 and 2) and after a ..
  39. pmc Exhaled nitric oxide levels in non-allergic and allergic mono- or polysensitised children with asthma
    M Silvestri
    Pulmonary Division, G. Gaslini Institute, Largo G Gaslini 5, 16148 Genoa, Italy
    Thorax 56:857-62. 2001
    ..Forced expiratory volume in 1 second (FEV(1)), forced vital capacity (FVC), forced expiratory flow at 25-75% of vital capacity (FEF(25-75%)), and the degree of bronchial ..
  40. pmc Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry
    Liam G Heaney
    Centre for Infection and Immunity, Queen s University of Belfast, Level 8, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, UK
    Thorax 65:787-94. 2010
    ....
  41. ncbi COPD exacerbations: definitions and classifications
    S Burge
    Birmingham Heartlands Hospital, Birmingham, UK
    Eur Respir J Suppl 41:46s-53s. 2003
    ..Healthcare utilisation is not an adequate substitute for severity, depending on many unrelated social and comorbidity factors. It is an outcome in its own right...
  42. pmc Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study
    Emily S Wan
    Channing Laboratory and Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 184:57-63. 2011
    ..These smokers are a poorly characterized group due to their systematic exclusion from chronic obstructive pulmonary disease (COPD) studies...
  43. pmc Percent emphysema, airflow obstruction, and impaired left ventricular filling
    R Graham Barr
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    N Engl J Med 362:217-27. 2010
    ....
  44. ncbi Marginal decline in forced vital capacity is associated with a poor outcome in idiopathic pulmonary fibrosis
    C J Zappala
    Royal Brompton Hospital and National Heart and Lung Institute, London, UK
    Eur Respir J 35:830-6. 2010
    ..In patients with biopsy-proven IPF (n = 84) and NSIP (n = 72), forced vital capacity (FVC) and diffusing capacity of the lung for carbon monoxide (D( L,CO)) trends at 6 months were categorised as ..
  45. ncbi Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol (1985) 104:394-403. 2008
    ..We partitioned airway obstruction into components of air trapping [indicated by forced vital capacity (FVC)] and airflow limitation [indicated by forced expiratory volume in 1 s (FEV(1))/FVC]...
  46. pmc Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study
    D M Mannino
    Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Thorax 58:388-93. 2003
    ..A study was undertaken to define the risk of death among a national cohort of US adults both with and without lung disease...
  47. ncbi Lung function impairment, COPD hospitalisations and subsequent mortality
    Judith Garcia-Aymerich
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Thorax 66:585-90. 2011
    ..A study was undertaken to examine the associations between lung function impairment and COPD hospitalisation, and COPD hospitalisation and mortality...
  48. ncbi Associations between birth weight, early childhood weight gain and adult lung function
    R J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Thorax 64:228-32. 2009
    ..It is also unclear whether postnatal growth affects adult lung function. The associations between birth weight, postnatal growth and adult lung function were assessed in an unselected birth cohort of 1037 children...
  49. pmc Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial
    Jurgen Behr
    Medizinische Klinik I, Klinikum Grosshadern der Ludwig Maximilians Universität, Munchen, Germany
    Respir Res 10:101. 2009
    ..e. slows down) disease progression in terms of vital capacity (VC) (+9%) and diffusing capacity (DLco) (+24%) in idiopathic pulmonary fibrosis (IPF)...
  50. pmc Regional chest wall volumes during exercise in chronic obstructive pulmonary disease
    A Aliverti
    Dipartimento di Bioingegneria, Politecnico di Milano, Italy
    Thorax 59:210-6. 2004
    ..However, it is unclear which patients are affected by dynamic hyperinflation and how the respiratory muscles respond to the change in lung volume...
  51. ncbi Concentration of matrix metalloproteinase-9 in serum of patients with chronic obstructive pulmonary disease and a degree of airway obstruction and disease progression
    B Brajer
    Department of Pulmonary Diseases, Poznan University of Medical Sciences, Poznan, Poland
    J Physiol Pharmacol 59:145-52. 2008
    ..01) and FEV1/FVC (P=0.0002). In conclusion, the results suggest that MMP-9 plays an important role in systemic inflammation in COPD. Higher MMP-9 serum concentration is connected with higher airway obstruction and disease progression...
  52. ncbi Relationship between lung function impairment and incidence or recurrence of cardiovascular events in a middle-aged cohort
    A K Johnston
    Division of Pulmonary and Critical Care Medicine, University of Kentucky Medical Center, 800 Rose Street, MN 614, Lexington, KY 40536, USA
    Thorax 63:599-605. 2008
    ..Lung function impairment may be a risk factor for cardiovascular disease (CVD) events...
  53. ncbi BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis
    Talmadge E King
    Department of Medicine, UCSF, 505 Parnassus Avenue, Room M994, San Francisco, CA 94110, USA
    Am J Respir Crit Care Med 177:75-81. 2008
    ..Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease lacking effective treatment...
  54. ncbi Cyclophosphamide versus placebo in scleroderma lung disease
    Donald P Tashkin
    University of California at Los Angeles, Los Angeles, USA
    N Engl J Med 354:2655-66. 2006
    ....
  55. ncbi Early emphysema in patients with anorexia nervosa
    Harvey O Coxson
    Department of Radiology, Vancouver Coastal Health Research Institute Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada
    Am J Respir Crit Care Med 170:748-52. 2004
    ..These data demonstrate that emphysema-like changes are present in the lungs of patients who are chronically malnourished...
  56. ncbi Not 15 but 50% of smokers develop COPD?--Report from the Obstructive Lung Disease in Northern Sweden Studies
    B Lundback
    Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Respir Med 97:115-22. 2003
    ..The prevalence of chronic obstructive pulmonary disease (COPD) according to guidelines of today seems considerably higher than has been reported also in recent literature...
  57. ncbi Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers
    J A Hardie
    Institute of Internal Medicine, Deaconess Hospital, University of Bergen, Norway
    Eur Respir J 20:1117-22. 2002
    ..defined stage I chronic obstructive pulmonary disease (COPD) as forced expiratory volume in one second/forced vital capacity (FEV1/FVC)% <70% and a FEV1% predicted of >80%...
  58. ncbi Impact of bronchodilator use on the prevalence of COPD in population-based samples
    Rogelio Perez-Padilla
    National Institute of Respiratory Diseases, Mexico City, Mexico
    COPD 4:113-20. 2007
    ....
  59. ncbi Lung function and incident coronary heart disease: the Atherosclerosis Risk in Communities Study
    Emily B Schroeder
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    Am J Epidemiol 158:1171-81. 2003
    ..the association between lung function, as measured by forced expiratory volume in 1 second (FEV1) and forced vital capacity, and the 10-year incidence of coronary heart disease among 14,480 participants in the Atherosclerosis Risk in ..
  60. ncbi Coexistent emphysema delays the decrease of vital capacity in idiopathic pulmonary fibrosis
    Takanori Akagi
    Department of Respiratory Medicine, Fukuoka University School of Medicine, 7 45 1, Nanakuma, Jonanku, Fukuoka 814 0180, Japan
    Respir Med 103:1209-15. 2009
    ..The baseline of vital capacity percent predicted (VC% pred) in CPFE patients was greater than that in IPF-alone patients (86.6+/-24.0% vs. 72...
  61. ncbi Maternal vitamin A supplementation and lung function in offspring
    William Checkley
    Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 362:1784-94. 2010
    ....
  62. ncbi Effectiveness of transcutaneous electrical nerve stimulation on postoperative pain with movement
    Barbara Rakel
    Department of Nursing Services and Patient Care, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Pain 4:455-64. 2003
    ..on pain with movement and at rest after abdominal surgery and evaluated whether its use during walking and vital capacity maneuvers enhances performance of these activities...
  63. ncbi Prognostic value of weight change in chronic obstructive pulmonary disease: results from the Copenhagen City Heart Study
    E Prescott
    Copenhagen City Heart Study, Bispebjerg Hospital, University of Copenhagen, Denmark
    Eur Respir J 20:539-44. 2002
    ..Subjects with COPD, defined as forced expiratory volume in one second/forced vital capacity < 0...
  64. pmc Alternative methods for assessing bronchodilator reversibility in chronic obstructive pulmonary disease
    J Hadcroft
    Department of Medicine, University of Liverpool, University Hospital Aintree, Liverpool L9 7AL, UK
    Thorax 56:713-20. 2001
    ..Spirometric parameters, slow vital capacity (SVC), inspiratory capacity (IC), and NEP were measured seated, before and after nebulised saline, and at ..
  65. ncbi Prevalence and underdiagnosis of COPD by disease severity and the attributable fraction of smoking Report from the Obstructive Lung Disease in Northern Sweden Studies
    Anne Lindberg
    The OLIN Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten, SE 971 80 Luleå, Sweden
    Respir Med 100:264-72. 2006
    ..The impact of smoking was evaluated by the population attributable fraction of smoking in COPD...
  66. ncbi Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Departments of Medicine and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 160:542-9. 1999
    ..IC should be used in conjunction with FEV(1) when evaluating therapeutic responses in COPD...
  67. ncbi Effect of vital capacity manoeuvres on arterial oxygenation in morbidly obese patients undergoing open bariatric surgery
    V Chalhoub
    Hotel Dieu de France Hospital, Department of Anaesthesia and Critical Care, Beirut, Lebanon
    Eur J Anaesthesiol 24:283-8. 2007
    ..The aim of this study was to evaluate the effect of a vital capacity manoeuvre (VCM), followed by ventilation with positive end-expiratory pressure (PEEP), on arterial oxygenation ..
  68. ncbi Thoracoplasty in thoracic adolescent idiopathic scoliosis
    Se Il Suk
    Seoul Spine Institute, Inje University Sanggye Paik Hospital, Seoul, Korea
    Spine (Phila Pa 1976) 33:1061-7. 2008
    ..Retrospective study...
  69. pmc Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study
    Hsin Chieh Yeh
    Department of Epidemiology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Diabetes Care 31:741-6. 2008
    ..The aim of this study was to test the hypothesis that diabetes is independently associated with reduced lung function, both cross-sectionally and longitudinally...
  70. pmc Patterns of dynamic hyperinflation during exercise and recovery in patients with severe chronic obstructive pulmonary disease
    I Vogiatzis
    National and Kapodistrian University of Athens Medical School, Thorax Foundation, Centre for Applied Biomedical Research and Education, 10675 Athens, Greece
    Thorax 60:723-9. 2005
    ..The pattern of change in chest wall volumes (Vcw) was investigated in patients with severe COPD who progressively hyperinflate during exercise and those who do not...
  71. ncbi High-dose acetylcysteine in idiopathic pulmonary fibrosis
    Maurits Demedts
    University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
    N Engl J Med 353:2229-42. 2005
    ..Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor prognosis...
  72. ncbi Normative values of pulmonary function testing in Chinese adults
    Jinping Zheng
    Guangzhou Institute of Respiratory Disease, Guangzhou Medical College, Guangzhou 510120, China
    Chin Med J (Engl) 115:50-4. 2002
    ..To compare the difference in pulmonary function between Caucasians and Chinese and assess the best reference values of pulmonary function for Chinese adults...
  73. ncbi Smoking cessation, lung function, and weight gain: a follow-up study
    Susan Chinn
    Department of Public Health Sciences, King s College London, 5th Floor Capital House, 42 Weston Street, London SE1 3QD, UK
    Lancet 365:1629-35; discussion 1600-1. 2005
    ..We estimated the net benefit of smoking cessation, and the independent effects of smoking and weight change on change in ventilatory lung function in the international European Community Respiratory Health Survey...
  74. pmc Early growth and adult respiratory function in men and women followed from the fetal period to adulthood
    Dexter Canoy
    Department of Public Health Science and General Practice, University of Oulu, Finland
    Thorax 62:396-402. 2007
    ..A study was undertaken to determine the association between early growth and adult respiratory function...
  75. ncbi Air stacking and chest compression increase peak cough flow in patients with Duchenne muscular dystrophy
    Magneide Fernandes Brito
    Sleep Medicine and Biology Division of the Psychobiology Department of the Universidade Federal de São Paulo UNIFESP, Federal University of São Paulo São Paulo, Brazil
    J Bras Pneumol 35:973-9. 2009
    ..To evaluate cough efficiency using two manually-assisted cough techniques...
  76. ncbi Comparison of two questionnaires which measure the health-related quality of life of idiopathic pulmonary fibrosis patients
    C S Zimmermann
    Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil
    Braz J Med Biol Res 40:179-87. 2007
    ..5 +/- 15.6%, forced vital capacity = 70.4 +/- 19.4%, and carbon monoxide diffusing capacity = 41.5 +/- 16...
  77. ncbi Neural respiratory drive as a physiological biomarker to monitor change during acute exacerbations of COPD
    Patrick B Murphy
    Lane Fox Respiratory Unit, St Thomas Hospital, Westminster Bridge Road, London SE1 7EH, UK
    Thorax 66:602-8. 2011
    ..It was hypothesised that lack of a fall in neural respiratory drive would identify patients at risk of treatment failure and early hospital readmission...
  78. ncbi The effect of air pollution on lung development from 10 to 18 years of age
    W James Gauderman
    Department of Preventive Medicine, University of Southern California, Los Angeles 90089, USA
    N Engl J Med 351:1057-67. 2004
    ..Whether exposure to air pollution adversely affects the growth of lung function during the period of rapid lung development that occurs between the ages of 10 and 18 years is unknown...
  79. pmc Forced expiratory flow between 25% and 75% of vital capacity and FEV1/forced vital capacity ratio in relation to clinical and physiological parameters in asthmatic children with normal FEV1 values
    Michael R Simon
    Division of Allergy and Clinical Immunology, William Beaumont Hospital, Royal Oak, Mich, USA
    J Allergy Clin Immunol 126:527-34.e1-8. 2010
    The assumption that the assessment of forced expiratory flow between 25% and 75% of vital capacity (FEF(25-75)) does not provide additional information in asthmatic children with normal FEV(1) percent predicted has not been adequately ..
  80. ncbi Interpreting lung function data using 80% predicted and fixed thresholds identifies patients at increased risk of mortality
    David M Mannino
    Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, 121 Washington Ave, Lexington, KY 40536, USA
    Chest 141:73-80. 2012
    ..This study investigated mortality in a representative sample of the US adult population with COPD by comparing abnormality determined using GOLD criteria to that determined using LLN criteria...
  81. ncbi Long term cardiopulmonary effects of closed repair of pectus excavatum
    David L Sigalet
    Alberta Children s Hospital, University of Calgary, 2888 Shaganappi Trail NW, Calgary, Canada
    Pediatr Surg Int 23:493-7. 2007
    ....
  82. ncbi Time course of expiratory flow limitation in COPD patients during acute respiratory failure requiring mechanical ventilation
    Valentina Alvisi
    Department of Anesthesiology, University of Ferrara, Italy
    Chest 123:1625-32. 2003
    ....
  83. pmc Development and validity testing of an IPF-specific version of the St George's Respiratory Questionnaire
    Janelle Yorke
    School of Nursing, Faculty of Health and Social Care, University of Salford, Salford, Greater Manchester, UK
    Thorax 65:921-6. 2010
    ..Some SGRQ items will inevitably have weaker measurement properties than others when applied to this population. This study was conducted to develop an IPF-specific version of the SGRQ...
  84. ncbi Validation of FEV6 in the elderly: correlates of performance and repeatability
    V Bellia
    Universitè di Palermo, DIMPEFINU, Via Trabucco 180, 90146 Palermo, Italy
    Thorax 63:60-6. 2008
    Forced expiratory volume in 6 s (FEV6) has been proposed as a more easily measurable parameter than forced vital capacity (FVC) to diagnose airway disease using spirometry...
  85. ncbi Ventilatory parameters and maximal respiratory pressure changes with age in Duchenne muscular dystrophy patients
    Jerome Gayraud
    INSERM, ERI25, Montpellier F 34295, France
    Pediatr Pulmonol 45:552-9. 2010
    ..in children with Duchenne muscular dystrophy, the respective functional interest of ventilatory parameters (Vital capacity, total lung capacity and forced expiratory volume in one second [FEV(1)]) in comparison to maximal inspiratory ..
  86. pmc Volume effect and exertional dyspnoea after bronchodilator in patients with COPD with and without expiratory flow limitation at rest
    E Boni
    Cattedra di Medicina I, Universita di Brescia, Italy
    Thorax 57:528-32. 2002
    ....
  87. pmc Reduced lung function is independently associated with increased risk of type 2 diabetes in Korean men
    Chang Hee Kwon
    Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Cardiovasc Diabetol 11:38. 2012
    ..Reduced lung function is associated with incident insulin resistance and diabetes. The aim of this study was to assess the relationship between lung function and incident type 2 diabetes in Korean men...
  88. ncbi Lung function, coronary artery calcification, and metabolic syndrome in 4905 Korean males
    Hye Yun Park
    Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Respir Med 104:1326-35. 2010
    ....
  89. ncbi Prognostic value of FEV1/FEV6 in elderly people
    Claudio Sorino
    Department of Medicine, Pneumology, Physiology and Human Nutrition, University of Palermo, Via Trabucco 180, Palermo, Italy
    Clin Physiol Funct Imaging 31:101-7. 2011
    ..in 1 s and forced expiratory volume in 6 s (FEV1/FEV6) has been proposed as an alternative for FEV1/forced vital capacity (FVC) to diagnose obstructive diseases with less effort during spirometry; however, its prognostic value is ..
  90. ncbi Plasma markers of inflammation and incidence of hospitalisations for COPD: results from a population-based cohort study
    G Engstrom
    Department of Clinical Sciences, University of Lund, Lund, Sweden
    Thorax 64:211-5. 2009
    ..This population-based study explored whether raised levels of five inflammation-sensitive plasma proteins (ISPs) predicted hospital admissions for COPD during 25 years of follow-up...
  91. ncbi Respiratory parameters during professional flute playing
    I Cossette
    Meakins Christie Laboratories, McGill University, 3626 rue St Urbain, Quebec, H2X 2PZ, Montreal, Canada
    Respir Physiol 121:33-44. 2000
    We studied three professional flautists while playing to determine: (1) what respiratory muscles and percent vital capacity (%VC) were used; (2) how mouth pressure (Pm), embouchure resistance (Rem), embouchure aperture (Aem), flow (V) and ..
  92. ncbi Short-term transcutaneous electrical nerve stimulation after cardiac surgery: effect on pain, pulmonary function and electrical muscle activity
    Gerson Cipriano
    Cardiovascular Surgery Division, Department of Surgery, Federal University of Sao Paulo, Napoleão de Barros, 715, 3rd Floor, 04023 002, Sao Paulo, SP, Brazil
    Interact Cardiovasc Thorac Surg 7:539-43. 2008
    ..also improvement in chest wall-pulmonary mechanics after TENS with proportional increases in tidal volume and vital capacity (P<0.05)...
  93. pmc The association of pipe and cigar use with cotinine levels, lung function, and airflow obstruction: a cross-sectional study
    Josanna Rodriguez
    Columbia University Medical Center, PH 9 East, Room 105, 630 West 168th Street, New York, NY 10032, USA
    Ann Intern Med 152:201-10. 2010
    ..Cigarette smoking is the major cause of chronic obstructive pulmonary disease, but studies on the contribution of other smoking techniques are sparse...
  94. ncbi Do NHLBI lung function criteria apply to children? A cross-sectional evaluation of childhood asthma at National Jewish Medical and Research Center, 1999-2002
    Keith Paull
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Pediatr Pulmonol 39:311-7. 2005
    ..In total, 2,728 children performed 24,388 measures. The mean +/- SD values for forced vital capacity (FVC), forced expired volume in 1 sec (FEV(1)), FEV(1)/FVC ratio, and forced expiratory flow (FEF)(25-75) were ..
  95. ncbi Interpreting lung function data using 80% predicted and fixed thresholds misclassifies more than 20% of patients
    Martin R Miller
    Department of Medicine, Queen Elizabeth Hospital Birmingham, 5th Floor Nuffield House, Birmingham B15 2TH, England
    Chest 139:52-9. 2011
    ..Misclassification of the full range of lung diseases in large patient groups when using GOLD/PP criteria instead of the LLN has not been explored previously...
  96. ncbi Rapid lung volumetry using ultrafast dynamic magnetic resonance imaging during forced vital capacity maneuver: correlation with spirometry
    Andy J Swift
    Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom
    Invest Radiol 42:37-41. 2007
    ..The aim of this study was to perform rapid lung volumetry using ultrafast dynamic MRI to capture a forced vital capacity (FVC) maneuver.
  97. ncbi Longitudinal assessment of spirometry in the World Trade Center medical monitoring program
    Gwen S Skloot
    Division of Pulmonary and Critical Care Medicine, Mount Sinai Medical Center, New York, NY 10029, USA
    Chest 135:492-8. 2009
    ..We also determined the predictors of spirometric change between the two examinations...
  98. ncbi Comparison of continuous and intermittent transcutaneous electrical nerve stimulation in postoperative pain management after coronary artery bypass grafting: a randomized, placebo-controlled prospective study
    Ozlem Solak
    Department of Physical Medicine and Rehabilitation, Afyon Kocatepe University, School of Medicine, Afyonkarahisar, Turkey
    Heart Surg Forum 12:E266-71. 2009
    ..We compared the effectiveness of continuous transcutaneous electrical nerve stimulation (TENS) and intermittent TENS in the management of pain after coronary artery bypass grafting (CABG)...
  99. ncbi Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease
    Ke Wang
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
    Chin Med J (Engl) 120:1051-7. 2007
    ..To investigate the relationship of CaCC(1) and mucus overproduction in the airway of Chinese patients with COPD, the expressions of CaCC(1), MUC5AC and mucus in bronchial tissues were examined...
  100. ncbi Serial changes in nasal potential difference and lung electrical impedance tomography at high altitude
    Nicholas P Mason
    Department of Physiology, Free University of Brussels, B1070 Brussels, Belgium
    J Appl Physiol (1985) 94:2043-50. 2003
    ..05), but the change in potential difference with superperfusion of amiloride or isoprenaline was unaffected. Vital capacity (VC) fell on ascent to 3,800 m (P < 0...
  101. ncbi Neural respiratory drive in healthy subjects and in COPD
    C J Jolley
    Dept of Asthma, Allergy and Respiratory Science, King s College London School of Medicine, King s College Hospital, Bessemer Road, London SE5 9PJ, UK
    Eur Respir J 33:289-97. 2009
    ..9+/-9.9% in COPD patients, and correlated with percentage predicted forced expiratory volume in one second, vital capacity and inspiratory capacity in patients...

Research Grants65

  1. Phase II/III Study of Arimoclomol in the Treatment of SOD1 Positive Familial?.
    Merit E Cudkowicz; Fiscal Year: 2013
    ..Secondary outcome measures include time to tracheostomy or permanent assisted ventilation, forced vital capacity, negative inspiratory force, strength, long-term safety and tolerability of arimoclomol as well as motor unit ..
  2. MOCSLID-DCC
    Robert M Elashoff; Fiscal Year: 2012
    ..to determine whether MMF is more effective than CYC over the 2nd yr of a 24-mo period with respect to forced vital capacity as the PRIMARY OUTCOME and overall toxicity;2) to compare MMF and CYC on the course of total lung capacity, ..
  3. Panic-Relevant Sensations and Smoking Motivation
    SAMANTHA GWEN FARRIS; Fiscal Year: 2013
    ..Participants will be randomly assigned to inhale a single vital capacity of 35% carbon dioxide [CO2]-enriched air mixture or compressed room air (control condition);this procedure is ..
  4. Rituximab Therapy in Patients with IPF
    KEVIN FITZGERALD GIBSON; Fiscal Year: 2013
    ..with clinical progression (anti-heat shock protein 70), as well as a measure of lung function (forced vital capacity), and adverse event rates...
  5. Pilot Placebo-Controlled Trial of Early Noninvasive Ventilation for ALS
    Kirsten L Gruis; Fiscal Year: 2011
    ..of respiratory muscle weakness with nocturnal noninvasive positive pressure ventilation (NIPPV) when forced vital capacity (FVC) is less than 50%, but prior to the development of respiratory failure, has prolonged survival in ..
  6. MOCSLID-CCC
    Donald P Tashkin; Fiscal Year: 2012
    ..to determine whether MMF is more effective than CYC over the 2nd yr of a 24-mo period with respect to forced vital capacity as the PRIMARY OUTCOME and overall toxicity;2) to compare MMF and CYC on the course of total lung capacity, ..
  7. Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)
    Anne B Newman; Fiscal Year: 2010
    ..including vascular (carotid wall thickness), brain (cognition), kidney (creatinine), pulmonary (forced vital capacity), metabolic ( fasting glucose), musculoskeletal (grip strength) systems and to rank individuals with the least ..
  8. Quantitative Magnetic Resonance Imaging of Biofilm in Cystic Fibrosis
    Rebecca J Theilmann; Fiscal Year: 2013
    ..of abnormally high lung water density and these locations shift spatially after patients complete 2 to 4 vital capacity maneuvers. Neither observation is seen in healthy subjects...
  9. Passive stretch of the chest wall in patients with Congential Muscular Dystrophy
    Raouf S Amin; Fiscal Year: 2013
    ..enrolled in the intervention group and 17 in the observational group, the difference in the rate of decline of vital capacity between the 2 groups will yield an effect size of >0.5...
  10. Treatment of IPF with Laparoscopic Anti-reflux Surgery
    Ganesh Raghu; Fiscal Year: 2013
    ..of abnormal GER with laparoscopic fundoplication will slow the progression of IPF as measured by the forced vital capacity (FVC)...
  11. Phase III Trial of Minocycline in ALS:I-Clinical Center
    Paul Gordon; Fiscal Year: 2007
    ..measures consist of changes in disease progression rate as measured by manual muscle testing (MMT), forced vital capacity (percent predicted) and survival...
  12. Testing a Measurement Model of Acute Dyspnea
    Mark Parshall; Fiscal Year: 2005
    ..Participants will be asked to complete a daily dyspnea questionnaire and perform bedside pyrometer (forced vital capacity and forced expiratory volume in the 1st sec) on three consecutive days; b-type natriuretic peptide (BNP) will ..
  13. FOR-DMD:Double-blind randomized trial to optimize steroid regimen in Duchenne MD
    Robert C Griggs; Fiscal Year: 2013
    ..analysis will be based on a multivariate (3-dimensional) outcome (time to rise from the floor, forced vital capacity, and treatment satisfaction) and global tests of the null hypothesis that the corticosteroid regimens do not ..
  14. PHASE III TRIAL FO SIROLIMUS IN LYMPHANGIOLEIOMYLMATOSIS
    Francis McCormack; Fiscal Year: 2009
    ..Secondary outcome measures will include forced vital capacity, residual volume, diffusing capacity, six minute walk, cyst volume percent based on volumetric CT, all-cause ..
  15. ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SSC ALVEOLITIS
    Dean Schraufnagel; Fiscal Year: 2003
    ..The mortality rate of patients with a forced vital capacity (FVC) <50% of predicted due to SSc pulmonary fibrosis is 40-45% within 10 years of SSc onset...
  16. ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SSC ALVEOLITIS
    Daniel Furst; Fiscal Year: 2001
    ..The mortality rate of patients with a forced vital capacity (FVC) less than 50 percent of predicted due to SSc pulmonary fibrosis is 40-45 percent within 10 years of SSc ..
  17. ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SSC ALVEOLITIS
    James Dauber; Fiscal Year: 2000
    ..The mortality rate of patients with a forced vital capacity (FVC) <50% of predicted due to SSc pulmonary fibrosis is 40-45% within 10 years of SSc onset...
  18. ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SSC ALVEOLITIS
    Charles Read; Fiscal Year: 2003
    ..The mortality rate of patients with a forced vital capacity (FVC) <50% of predicted due to SSc pulmonary fibrosis is 40-45% within 10 years of SSc onset...
  19. Biostatistics and Data Management for a Trial of Corticosteroid Regimens in DMD
    Rabi Tawil; Fiscal Year: 2012
    ..will be three-dimensional and will consist of (1) time to stand from lying (log-transformed), (2) forced vital capacity, and (3) subject/parent global satisfaction with treatment, all averaged over all post-baseline visits during ..
  20. Clinical Trial of Ceftriaxone in ALS
    Merit Cudkowicz; Fiscal Year: 2004
    ..Secondary outcome measures will include ALSFRS-R, vital capacity, strength, and the long-term safety and tolerability of ceftriaxone in this population.
  21. SCLERODERMA LUNG STUDY
    Robert Elashoff; Fiscal Year: 2006
    ..The mortality rate of patients with a forced vital capacity (FVC) <50% of predicted due to SSc pulmonary fibrosis is 40-45% within 10 years of SSc onset...
  22. SCLERODERMA LUNG STUDY
    Mitchell Olman; Fiscal Year: 2001
    ..The mortality rate of patients with a forced vital capacity (FVC) <50% of predicted due to SSc pulmonary fibrosis is 40-45% within 10 years of SSc onset...
  23. SCLERODERMA LUNG STUDY
    Maureen Mayes; Fiscal Year: 2003
    ..The mortality rate of patients with a forced vital capacity (FVC) <50% of predicted due to SSc pulmonary fibrosis is 40-45% within 10 years of SSc onset...
  24. SCLERODERMA LUNG STUDY
    Arthur Theodore; Fiscal Year: 2003
    ..The mortality rate of patients with a forced vital capacity (FVC) <50% of predicted due to SSc pulmonary fibrosis is 40-45% within 10 years of SSc onset...
  25. SCLERODERMA LUNG STUDY
    David Riley; Fiscal Year: 2003
    ..The mortality rate of patients with a forced vital capacity (FVC) <50% of predicted due to SSc pulmonary fibrosis is 40-45% within 10 years of SSc onset...
  26. SCLERODERMA LUNG STUDY
    Richard Silver; Fiscal Year: 2003
    ..The mortality rate of patients with a forced vital capacity (FVC) <50% of predicted due to SSc pulmonary fibrosis is 40-45% within 10 years of SSc onset...
  27. Plan forTrial to find Optimum Steroid Regimen in Duchenne Muscular Dystrophy
    ROBERT GRIGGS; Fiscal Year: 2006
    ..analysis will be based on a multivariate (3-dimensional) outcome (time to rise from the floor, forced vital capacity, and treatment satisfaction) and a global test of the null hypothesis that the corticosteroid regimens do not ..
  28. CREATINE IN AMYOTROPHIC LATERAL SCLEROSIS
    Jeffrey Rosenfeld; Fiscal Year: 2004
    ..Secondary endpoints include the rate of decline of forced vital capacity (FVC, percent predicted), the change in the ALS functional rating scale (ALSFRS-R), the SF-12 (quality of life ..
  29. HEALTH OF YOUNG ADULTS--EVIDENCE CAUSES AND OUTCOMES
    DORA COSTA; Fiscal Year: 2000
    ..the ratio of chest circumference to height, and the ratio of chest circumference to shoulder diameter, and vital capacity is available...
  30. Lung Radiation Protection by MnSOD Transgene Therapy
    Joel Greenberger; Fiscal Year: 2005
    ..an unexplained latent period which follows the acute reaction and is characterized by reduction in pulmonary vital capacity and exertional dyspnea...
  31. Microarray biomarkers of disease activity and progression in systemic sclerosis
    Robert Lafyatis; Fiscal Year: 2009
    ..Although the Modified Rodnan Skin Score and Forced Vital Capacity have served as valuable tools for measuring the extent of skin and pulmonary disease, it would be valuable for ..
  32. CHILDREN'S MECHANISMS FOR VARYING VOCAL INTENSITY
    Elaine Stathopoulos; Fiscal Year: 1993
    ..Dependent measures for respiration include per cent vital capacity used, maximum end-inspiratory level, and maximum end-expiratory level...
  33. HEALTH EFFECTS OF PARTICULATE ACIDS IN LATE ADOLESCENCE
    FRANK SPEIZER; Fiscal Year: 2000
    ..75), forced vital capacity (FVC)), and measures of flow at low lung volumes...
  34. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2008
    ..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
  35. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Donald Tashkin; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate in this study. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  36. SCLERODERMA LUNG STUDY
    Donald Tashkin; Fiscal Year: 2003
    ..The mortality rate of patients with a forced vital capacity (FVC) <50% of predicted due to SSc pulmonary fibrosis is 40-45% within 10 years of SSc onset...
  37. Modeling of Aerosol Transport in Alveolated Airways
    Chantal Darquenne; Fiscal Year: 2009
    ..The results of this study will provide a link to the mechanisms by which even seemingly modest PM exposure can cause or exacerbate lung disease and will also help to better design spatial targeting of inhaled drugs. ..
  38. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2009
    ..3) Define and quantify the relationship between alterations in the heterogeneity of pulmonary blood flow and lung water content using functional magnetic resonance imaging (fMRI) and X-ray techniques. ..
  39. Deposition of 0.5 to 2 Micron Aerosol in the Human Lung
    G Prisk; Fiscal Year: 2003
    ..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
  40. Genetic Determinants of COPD in Diverse Ethnic Groups
    Edwin K Silverman; Fiscal Year: 2010
    ..The overall goal of this proposal is to test the hypothesis that shared genetic determinants influence the development of COPD in diverse ethnic groups. ..
  41. Asthma Candidate Genes in Alpha 1-Antitrypsin Deficiency
    Dawn DeMeo; Fiscal Year: 2007
    ..The identification of modifying factors of COPD in AAT deficiency may have significant public health relevance to COPD patients without AAT deficiency. ..
  42. Genetic Modifiers of Alpha 1-Antitrypsin Deficiency
    Edwin Silverman; Fiscal Year: 2005
    ....
  43. A Genome-wide Association Study of Childhood Respiratory Outcomes
    WILLIAM GAUDERMAN; Fiscal Year: 2009
    ..End of Abstract) ..
  44. CRITICAL FACTORS IN THE DEVELOPMENT OF LEARNING
    MARIETA HEATON; Fiscal Year: 1980
    ..understanding of developmental factors critical to emerging learning will eventually enable us to promote, protect and nurture these crucial prerequisites, and to ultimately prevent the abnormal development of this vital capacity.
  45. Gene by Environment Interactions in Asthma and Allergy
    Augusto Litonjua; Fiscal Year: 2009
    ..Blood for genetic material is currently being collected on the two cohorts, and endotoxin will be measured from stored, frozen house dust. ..
  46. STATISTICAL APPROACHES TO THE STUDY OF GXE INTERACTIONS
    W Gauderman; Fiscal Year: 2002
    ..Successful completion of these aims will improve our understanding of how GxE interaction influences disease risk, and how we can optimally design studies and analyze data to find and characterize such genes. ..
  47. Fish Oil Intake, Biomarkers and Change in Lung Function
    R Barr; Fiscal Year: 2008
    ..Use of this existing cohort with previously collected blood samples will provide relatively cost-effective results about this potentially promising and safe therapy for COPD. ..
  48. BETA-2 ADRENERGIC RECEPTOR POLYMORPHISMS AND ASTHMA
    Augusto Litonjua; Fiscal Year: 2002
    ..End of Abstract) ..
  49. APPROACHES TO THE GENETICS OF COPD
    Edwin Silverman; Fiscal Year: 2003
    ..abstract_text> ..
  50. Vitamin D in Obstructive Lung Diseases
    Augusto Litonjua; Fiscal Year: 2008
    ..Additionally, supplementation with vitamin D can be implemented in cost-effective population-based programs to prevent the development of, and treat these disorders. [unreadable] [unreadable] [unreadable]..
  51. Longitudinal Lung Function Changes--Aging/Genetics/Risk
    Augusto Litonjua; Fiscal Year: 2008
    ..The results of this proposal will shed light on potential mechanisms that affect lung function decline in aging. ..
  52. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2008
    ..abstract_text> ..
  53. Genetics of COPD in NETT
    Edwin Silverman; Fiscal Year: 2005
    ..abstract_text> ..
  54. STRUCTURAL MECHANISMS OPERATING IN UNRESPONSIVE ASTHMA
    Robert Brown; Fiscal Year: 2003
    ....
  55. NASD Academic ED Collaborative - UC San Diego
    Theodore Chan; Fiscal Year: 2004
    ..UCSD ED investigators will be responsible for following up on difficult to reach) patients. Local data and survey results will be submitted to the R-25 and R-21 sites for analysis. ..
  56. Responses to Surgical and Bronchoscopic Volume Reduction
    Edward Ingenito; Fiscal Year: 2006
    ..We believe that by accomplishing these objectives, we can help advance this technology into the clinical arena. ..
  57. Pneumografting - a novel cell-based therapy for emphysema
    Edward P Ingenito; Fiscal Year: 2010
    ..We intend to advance this approach, known as pneumografting, into human trials under a physician-sponsored Investigation New Drug Application. ..
  58. Maternal overnutrition and offspring fat mass, metabolic and vascular function.
    Debbie Lawlor; Fiscal Year: 2009
    ....
  59. Forced expiration and lung volume in infant lung disease
    MOHY MORRIS; Fiscal Year: 2006
    ..abstract_text> ..
  60. Force Propagation of Emphysema in Vivo
    Edward Ingenito; Fiscal Year: 2007
    ..The results of these experiments will provide new insight into the role of mechanical forces in promoting injury in the intact emphysema lung, and the effect of mechanical forces on tissue remodeling. [unreadable] [unreadable]..
  61. Airway as Target Organ in Infants with Atopic Dermatitis
    Robert Tepper; Fiscal Year: 2008
    ..Specific Aim # 2: Evaluate whether the presence of phenotypic characteristics of the asthmatic airway identifies infants and toddlers that develop clinical asthma by 5 years of age. [unreadable] [unreadable]..
  62. Serum Inflammatory Biomarkers as Predictors of COPD Morbidity and Morality
    Stefano Guerra; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. Integrating and coordinating efforts in COPD guideline development
    Holger Schunemann; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  64. Strategies to Improve COPD Management
    Richard Casaburi; Fiscal Year: 2007
    ..These studies should have immediate impact on treatment strategies for large poor-prognosis subgroups of COPD patients. ..