lung compliance

Summary

Summary: The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)

Top Publications

  1. ncbi Use of dynamic compliance for open lung positive end-expiratory pressure titration in an experimental study
    Fernando Suarez-Sipmann
    Intensive Care Unit, Fundacion Jimenez Diaz Capio, Avenida de los Reyes Catolicos 2, 28010 Madrid, Spain
    Crit Care Med 35:214-21. 2007
  2. ncbi Invasive and noninvasive lung function measurements in rodents
    Heinz Gerd Hoymann
    Fraunhofer Institute of Toxicology and Experimental Medicine ITEM, Nikolai Fuchs Str 1, Hannover, Germany
    J Pharmacol Toxicol Methods 55:16-26. 2007
  3. ncbi Structural emphysema does not correlate with lung compliance: lessons from the mouse smoking model
    Robert F Foronjy
    Department of Medicine, Division of Molecular Medicine and Pulmonary Medicine, Columbia University, New York, USA
    Exp Lung Res 31:547-62. 2005
  4. ncbi A comparison of the effects of manual and ventilator hyperinflation on static lung compliance and sputum production in intubated and ventilated intensive care patients
    Susan Berney
    Department of Physiotherapy, Austin and Repatriation Medical Centre, Victoria, Australia
    Physiother Res Int 7:100-8. 2002
  5. ncbi Changes in lung volume and ventilation during surfactant treatment in ventilated preterm infants
    Martijn Miedema
    Department of Neonatology H3 214, Emma Children s Hospital AMC, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Am J Respir Crit Care Med 184:100-5. 2011
  6. pmc IUGR decreases elastin mRNA expression in the developing rat lung and alters elastin content and lung compliance in the mature rat lung
    Lisa A Joss-Moore
    Division of Neonatology, University of Utah, Salt Lake City, Utah, USA
    Physiol Genomics 43:499-505. 2011
  7. ncbi Lower inflection point and recruitment with PEEP in ventilated patients with acute respiratory failure
    M Mergoni
    Servizio di Anestesia e Rianimazione, Azienda Ospedaliera di Parma, 43100 Parma, Italy
    J Appl Physiol (1985) 91:441-50. 2001
  8. ncbi Tracking of airway and tissue mechanics during TLC maneuvers in mice
    Zoltan Hantos
    Dept of Medical Informatics, Univ of Szeged, Koranyi fasor 9, H 6720 Szeged, Hungary
    J Appl Physiol (1985) 95:1695-705. 2003
  9. ncbi Surfactant treatment for ventilation-induced lung injury in rats: effects on lung compliance and cytokines
    B Welk
    Department of Medicine, Lawson Health Research Institute, University of Western Ontario, London, Canada
    Exp Lung Res 27:505-20. 2001
  10. pmc Effect of closed endotracheal suction in high-frequency ventilated premature infants measured with electrical impedance tomography
    Mariëtte B van Veenendaal
    Department of Neonatology H3 144, Emma Children s Hospital AMC, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Intensive Care Med 35:2130-4. 2009

Research Grants

  1. TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNG
    Namasivayam Ambalavanan; Fiscal Year: 2012
  2. Neonatal Oxygen and Susceptibility to Respiratory Viral Infections
    MICHAEL A O'REILLY; Fiscal Year: 2013
  3. Mesenchymal Cell Fate Determination by Extracellular Matrix Stiffness
    Jeffrey C Horowitz; Fiscal Year: 2013
  4. Regulatory Tcells and the fibroproliferative response in Acute Lung Injury
    Brian Garibaldi; Fiscal Year: 2011
  5. Cardiolipin Induced Lung Injury and FIC1
    Rama K Mallampalli; Fiscal Year: 2013
  6. TRP Channels and Air Pollution
    Christopher A Reilly; Fiscal Year: 2013
  7. Structure/Function Analyses Of SP-B
    TIMOTHY EDWARD WEAVER; Fiscal Year: 2010
  8. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
  9. LUNG AND AIRWAY AFFERENTS AND THEIR REFLEX ROLE
    JOHN COLERIDGE; Fiscal Year: 1992
  10. THORACOABDOMINAL ASYNCHRONY IN INFANT AIRWAY OBSTRUCTION
    Julian Allen; Fiscal Year: 1992

Detail Information

Publications237 found, 100 shown here

  1. ncbi Use of dynamic compliance for open lung positive end-expiratory pressure titration in an experimental study
    Fernando Suarez-Sipmann
    Intensive Care Unit, Fundacion Jimenez Diaz Capio, Avenida de los Reyes Catolicos 2, 28010 Madrid, Spain
    Crit Care Med 35:214-21. 2007
    ..We tested whether the continuous monitoring of dynamic compliance could become a useful bedside tool for detecting the beginning of collapse of a fully recruited lung...
  2. ncbi Invasive and noninvasive lung function measurements in rodents
    Heinz Gerd Hoymann
    Fraunhofer Institute of Toxicology and Experimental Medicine ITEM, Nikolai Fuchs Str 1, Hannover, Germany
    J Pharmacol Toxicol Methods 55:16-26. 2007
    ....
  3. ncbi Structural emphysema does not correlate with lung compliance: lessons from the mouse smoking model
    Robert F Foronjy
    Department of Medicine, Division of Molecular Medicine and Pulmonary Medicine, Columbia University, New York, USA
    Exp Lung Res 31:547-62. 2005
    ..The study exposed 2 strains of mice (CBA/J/J x C57BL/6J and A/J) to chronic cigarette smoke. Lung compliance and morphometry were measured...
  4. ncbi A comparison of the effects of manual and ventilator hyperinflation on static lung compliance and sputum production in intubated and ventilated intensive care patients
    Susan Berney
    Department of Physiotherapy, Austin and Repatriation Medical Centre, Victoria, Australia
    Physiother Res Int 7:100-8. 2002
    ..The effects of manual hyperinflation, with respect to excess bronchial secretions and static lung compliance, have been well-established...
  5. ncbi Changes in lung volume and ventilation during surfactant treatment in ventilated preterm infants
    Martijn Miedema
    Department of Neonatology H3 214, Emma Children s Hospital AMC, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Am J Respir Crit Care Med 184:100-5. 2011
    ..The immediate and regional effects of exogenous surfactant in open lung high-frequency oscillatory ventilated (HFOV) preterm infants are unknown...
  6. pmc IUGR decreases elastin mRNA expression in the developing rat lung and alters elastin content and lung compliance in the mature rat lung
    Lisa A Joss-Moore
    Division of Neonatology, University of Utah, Salt Lake City, Utah, USA
    Physiol Genomics 43:499-505. 2011
    ..In the day 21 lung, IUGR decreases elastic fiber deposition and increases static lung compliance. We conclude that IUGR decreases mRNA transcript levels of elastic fiber synthesis genes, before and during ..
  7. ncbi Lower inflection point and recruitment with PEEP in ventilated patients with acute respiratory failure
    M Mergoni
    Servizio di Anestesia e Rianimazione, Azienda Ospedaliera di Parma, 43100 Parma, Italy
    J Appl Physiol (1985) 91:441-50. 2001
    ..A RV was found even when a LIP was not present. We conclude that the recruitment phenomenon is not closely related to the presence of a LIP and that a simple method can be used to measure RV...
  8. ncbi Tracking of airway and tissue mechanics during TLC maneuvers in mice
    Zoltan Hantos
    Dept of Medical Informatics, Univ of Szeged, Koranyi fasor 9, H 6720 Szeged, Hungary
    J Appl Physiol (1985) 95:1695-705. 2003
    ....
  9. ncbi Surfactant treatment for ventilation-induced lung injury in rats: effects on lung compliance and cytokines
    B Welk
    Department of Medicine, Lawson Health Research Institute, University of Western Ontario, London, Canada
    Exp Lung Res 27:505-20. 2001
    ..We conclude that surfactant treatment is beneficial in preventing VILI; however, it does not prevent the release of inrflammatory cytokines during mechanical ventilation...
  10. pmc Effect of closed endotracheal suction in high-frequency ventilated premature infants measured with electrical impedance tomography
    Mariëtte B van Veenendaal
    Department of Neonatology H3 144, Emma Children s Hospital AMC, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Intensive Care Med 35:2130-4. 2009
    ..To determine the global and regional changes in lung volume during and after closed endotracheal tube (ETT) suction in high-frequency ventilated preterm infants with respiratory distress syndrome (RDS)...
  11. ncbi Simple method to measure total expiratory time constant based on the passive expiratory flow-volume curve
    J X Brunner
    Research Department, Hamilton Bonaduz AG, Bonaduz, Switzerland
    Crit Care Med 23:1117-22. 1995
    ..15 sec for the dogs. CONCLUSIONS: The volume and peak flow corrected for limited exhalation time is a good estimate of the total expiratory time constant in passive subjects and may be useful for the titration of mechanical ventilation...
  12. ncbi Supramaximal inflation improves lung compliance in subjects with amyotrophic lateral sclerosis
    Noah Lechtzin
    Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Chest 129:1322-9. 2006
    b>Lung compliance has been found to be low in patients with chronic diaphragmatic weakness or paralysis but has not been well-studied in patients with amyotrophic lateral sclerosis (ALS)...
  13. ncbi Responses of bronchial C-fiber afferents of the rabbit to changes in lung compliance
    Amy Ma
    Division of Cardiovascular Medicine, University of California, Davis, One Shield s Avenue, TB 172, Davis, CA 95616, USA
    Respir Physiol Neurobiol 138:155-63. 2003
    Rapidly adapting receptors (RAR) in the lung are stimulated when the lung compliance is reduced...
  14. ncbi Immediate changes in lung compliance following natural surfactant administration in premature infants with respiratory distress syndrome: a controlled trial
    Mohammad A Attar
    Department of Pediatrics and Communicable Diseases, University of Michigan, MI, USA
    J Perinatol 24:626-30. 2004
    To compare immediate changes in lung compliance following the administration of two commercially available natural surfactants.
  15. ncbi Alveolar derecruitment at decremental positive end-expiratory pressure levels in acute lung injury: comparison with the lower inflection point, oxygenation, and compliance
    S M Maggiore
    Medical Intensive Care Unit, INSERM U492, Henri Mondor Teaching Hospital, AP-HP, Paris XII University, , France
    Am J Respir Crit Care Med 164:795-801. 2001
    ..9, p = 0.001), suggesting that compliance above LIP may reflect the amount of recruitable lung. Thus, alveolar closure in ALI occurs over a wide range of pressures, and LIP is a poor predictor of alveolar closure...
  16. ncbi Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome
    Davide Chiumello
    Dipartimento di Anestesia, Rianimazione, Intensiva e Subintensivae, Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Am J Respir Crit Care Med 178:346-55. 2008
    ..Lung injury caused by a ventilator results from nonphysiologic lung stress (transpulmonary pressure) and strain (inflated volume to functional residual capacity ratio)...
  17. ncbi Surfactant protein B inhibits endotoxin-induced lung inflammation
    Ralph Epaud
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Respir Cell Mol Biol 28:373-8. 2003
    ..b>Lung compliance and tissue damping were significantly decreased in SP-B(+/+) and SP-B(+/-) mice, but were not changed in SP-B(..
  18. ncbi Mechanics of respiratory system in healthy anesthetized humans with emphasis on viscoelastic properties
    B Jonson
    Department of Clinical Physiology, University of Lund, Sweden
    J Appl Physiol (1985) 75:132-40. 1993
    ..62 +/- 0.13 cmH2O x 1 for a breath of 0.56 liter, corresponding to 32% of the total energy loss within the RS. Viscoelastic recoil contributed as a driving force during the initial part of expiration...
  19. pmc How large is the lung recruitability in early acute respiratory distress syndrome: a prospective case series of patients monitored by computed tomography
    Gustavo F J de Matos
    Adult ICU Hospital Israelita Albert Einstein, Sao Paulo, 05652 000, Brazil
    Crit Care 16:R4. 2012
    ..The present study extends those results, describing a case-series of non-selected patients with early, severe ARDS submitted to MRS and followed until hospital discharge or death...
  20. ncbi Lung recruitment assessed by total respiratory system input reactance
    Raffaele L Dellaca
    Dipartimento di Bioingegneria, Politecnico di Milano University, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Intensive Care Med 35:2164-72. 2009
    ..The aim of this study was to investigate the possibility of monitoring the amount of derecruited lung by the forced oscillation technique (FOT)...
  21. ncbi The role of IL-13 in established allergic airway disease
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 169:6482-9. 2002
    ....
  22. ncbi Prolonged moderate pressure recruitment manoeuvre results in lower optimal positive end-expiratory pressure and plateau pressure
    K Lowhagen
    Department of Anaesthesia and Intensive Care Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Acta Anaesthesiol Scand 55:175-84. 2011
    ..Secondly, optimal PEEP levels following the RMs were compared, and the use of volume-dependent compliance (VDC) to identify successful lung recruitment and optimal PEEP was evaluated...
  23. ncbi Relationship between dynamic respiratory mechanics and disease heterogeneity in sheep lavage injury
    Carissa L Bellardine Black
    Department of Biomedical Engineering, Boston University, Boston, MA, USA
    Crit Care Med 35:870-8. 2007
    ....
  24. ncbi Intercomparison of recruitment maneuver efficacy in three models of acute lung injury
    Sung Chul Lim
    Department of Pulmonary Critical Care Medicine, Regions Hospital, University of Minnesota, St Paul, MN, USA
    Crit Care Med 32:2371-7. 2004
    ..To compare the relative efficacy of three forms of recruitment maneuvers in diverse models of acute lung injury characterized by differing pathoanatomy...
  25. ncbi Optimisation of positive end-expiratory pressure by forced oscillation technique in a lavage model of acute lung injury
    Raffaele L Dellaca
    Dipartimento di Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Intensive Care Med 37:1021-30. 2011
    ..We evaluated whether oscillatory compliance (C(X5)) measured by forced oscillation technique (FOT) at 5 Hz may be useful for positive end-expiratory pressure (PEEP) optimisation...
  26. ncbi Pressure/volume curves and lung computed tomography in acute respiratory distress syndrome
    J J Rouby
    Reanimation Chirurgicale Pierre Viars, Dept of Anesthesiology, Hospital Pitié Salpêtrière, University Paris VI, Paris, France
    Eur Respir J Suppl 42:27s-36s. 2003
    ..In such patients, alveolar recruitment resulting from positive end-expiratory pressure >10 cmH2O is preceded and accompanied by lung overinflation...
  27. ncbi An objective analysis of the pressure-volume curve in the acute respiratory distress syndrome
    R S Harris
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Respir Crit Care Med 161:432-9. 2000
    ..Calculating objective parameters such as P(mci,i) or P(inf,d) from curve-fitted P-V data can minimize this large variability...
  28. ncbi Respiratory mechanics and maximal expiratory flow in the anesthetized mouse
    Y L Lai
    Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan
    J Appl Physiol (1985) 88:939-43. 2000
    ....
  29. ncbi Impact of positive end-expiratory pressure on the definition of acute respiratory distress syndrome
    Elisa Estenssoro
    Servicio de Terapia Intensiva, Hospital Interzonal General de Agudos General San Martín, 1900, La Plata, Argentina
    Intensive Care Med 29:1936-42. 2003
    ..We examined whether PEEP during the first hours of ARDS can induce such a change in oxygenation that could mask fulfillment of the AECC criteria of a PaO(2)/FIO(2) </= 200 essential for ARDS diagnosis...
  30. ncbi Alveolar instability causes early ventilator-induced lung injury independent of neutrophils
    Jay M Steinberg
    Department of Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Am J Respir Crit Care Med 169:57-63. 2004
    ..To our knowledge, this is the first study to directly confirm that unstable alveoli are subjected to ventilator-induced lung injury whereas stable alveoli are not...
  31. ncbi Functional residual capacity and respiratory mechanics as indicators of aeration and collapse in experimental lung injury
    Christian Rylander
    Department of Anesthesia, Sahlgrenska University Hospital, Gothenburg, Sweden
    Anesth Analg 98:782-9, table of contents. 2004
    ..We found the functional residual capacity to be a more sensitive marker of the lung perturbations than the compliance. It might be of value to include functional residual capacity in the monitoring of acute lung injury...
  32. ncbi Best compliance during a decremental, but not incremental, positive end-expiratory pressure trial is related to open-lung positive end-expiratory pressure: a mathematical model of acute respiratory distress syndrome lungs
    K G Hickling
    Department of Anaesthesia and Intensive Care, HealthCare Otago, University of Otago, Dunedin, New Zealand
    Am J Respir Crit Care Med 163:69-78. 2001
    ..The maximum PV slope during a decremental PEEP trial with a low VT may be a useful method to determine open-lung PEEP in ARDS, and should be studied clinically...
  33. ncbi Assessment of regional lung recruitment and derecruitment during a PEEP trial based on electrical impedance tomography
    Torsten Meier
    Department of Anesthesiology, University Medical Center Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Intensive Care Med 34:543-50. 2008
    ..To investigate whether electrical impedance tomography (EIT) is capable of monitoring regional lung recruitment and lung collapse during a positive end-expiratory pressure (PEEP) trial...
  34. ncbi Unrestrained plethysmography is an unreliable measure of airway responsiveness in BALB/c and C57BL/6 mice
    Andy Adler
    School of Information Technology and Engineering, University of Ottawa, Ontario, Canada K1N 6N5
    J Appl Physiol (1985) 97:286-92. 2004
    ....
  35. ncbi Prevention of endotracheal suctioning-induced alveolar derecruitment in acute lung injury
    Salvatore M Maggiore
    Department of Anesthesiology and Intensive Care, Agostino Gemelli Teaching Hospital, Catholic University of the Sacred Heart, Rome, Italy
    Am J Respir Crit Care Med 167:1215-24. 2003
    ..9, p < 0.001). Oxygenation paralleled lung volume changes. Suctioning-induced lung derecruitment in acute lung injury can be prevented by performing recruitment maneuvers during suctioning and minimized by avoiding disconnection...
  36. ncbi Pressure-volume curves in acute respiratory distress syndrome: clinical demonstration of the influence of expiratory flow limitation on the initial slope
    Antoine Vieillard-Baron
    Medical Intensive Care Unit, and Department of Biostatistics, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, Boulogne Cedex, France
    Am J Respir Crit Care Med 165:1107-12. 2002
    ....
  37. ncbi Comparison of bronchodilating and antiinflammatory activities of oral formoterol and its (R,R)-enantiomers
    Qiang Min Xie
    Zhejiang Respiratory Drugs Research Laboratory of State Drugs Administration of China, Medical School of Zhejiang University, Hangzhou 310031
    Acta Pharmacol Sin 24:277-82. 2003
    ..To compare the bronchodilating and antiinflammatory effects of oral racemic formoterol (rac-FMT) and (R,R)-formoterol (R,R-FMT)...
  38. ncbi Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury
    Minqing Zhao
    Department of Surgery, University of Virginia Health System, P O Box 801359, Charlottesville, 22908, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1018-26. 2006
    ..We conclude that AMs are an essential player in the initiation of acute lung I/R injury...
  39. ncbi Lung recruitment maneuver depresses central hemodynamics in patients following cardiac surgery
    Jonas Nielsen
    Department of Anesthesia and Intensive Care Medicine, Copenhagen University Hospital Gentofte, Niels Andersens Vej 64, 2900 Hellerup, Denmark
    Intensive Care Med 31:1189-94. 2005
    ..To assess the impact of the lung recruitment maneuver on circulation following cardiac surgery...
  40. pmc Measuring the lung function in the mouse: the challenge of size
    Charles G Irvin
    Vermont Lung Center, Department of Medicine, College of Medicine, University of Vermont, Room 226, HSRF, 149 Beaumont Avenue, Burlington, VT 05405, USA
    Respir Res 4:4. 2003
    ..These advances, resulting in our current ability to measure sophisticated indices of lung function in laboratory animals, are likely to lead to important insights into the mechanisms of lung disease...
  41. ncbi Comparison of the response to the prone position between pulmonary and extrapulmonary acute respiratory distress syndrome
    C M Lim
    Division of Pulmonary and Critical Care Medicine, Asan Medical Centre, College of Medicine, University of Ulsan, Seoul 138 600, Korea
    Intensive Care Med 27:477-85. 2001
    ..To determine whether the response to the prone position differs between acute respiratory distress syndrome (ARDS) resulting from a pulmonary cause (ARDSp) and that from an extrapulmonary cause (ARD-Sexp)...
  42. ncbi Bronchoscopic surfactant administration preserves gas exchange and pulmonary compliance after single lung transplantation in dogs
    Ivar Friedrich
    Department of Cardiothoracic Surgery, Martin Luther University, Halle, Germany
    J Thorac Cardiovasc Surg 127:335-43. 2004
    ..Surfactant abnormalities have been implicated in reperfusion injury and respiratory failure in lung transplantation...
  43. ncbi Pulmonary responses to bronchoconstrictor agonists in the mouse
    T R Martin
    Department of Pediatrics, Children s Hospital, Boston, Massachusetts 02215
    J Appl Physiol (1985) 64:2318-23. 1988
    ..As a result, this model offers unique advantages for identifying the roles of individual inflammatory cell types or mediators in pulmonary processes, including pulmonary anaphylaxis...
  44. pmc Dynamic determination of oxygenation and lung compliance in murine pneumonectomy
    Barry C Gibney
    Laboratory of Adaptive and Regenerative Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Exp Lung Res 37:301-9. 2011
    ..Sustained inflation pressures, referred to as a "recruitment maneuver," improved lung volumes, lung compliance, and arterial oxygenation...
  45. ncbi Open lung ventilation preserves the response to delayed surfactant treatment in surfactant-deficient newborn piglets
    Mariëtte B van Veenendaal
    Department of Neonatology, Emma Children s Hospital AMC, University of Amsterdam, Amsterdam, The Netherlands
    Crit Care Med 34:2827-34. 2006
    ..The objective of this study was to evaluate if this time-dependent efficacy of surfactant treatment is also present during open lung ventilation...
  46. pmc Bench and mathematical modeling of the effects of breathing a helium/oxygen mixture on expiratory time constants in the presence of heterogeneous airway obstructions
    Andrew R Martin
    Medical Gases, American Air Liquide, Delaware Research and Technology Center DRTC, 200 GBC Drive, Newark, DE 19702, USA
    Biomed Eng Online 11:27. 2012
    ..In the present work, bench and mathematical models of the lung were used to study the influence of heterogeneous patterns of obstruction on compartmental and whole-lung time constants...
  47. ncbi What has been learnt from P/V curves in patients with acute lung injury/acute respiratory distress syndrome
    S M Maggiore
    Dept of Anaesthesiology and Intensive Care, Agostino Gemelli Hospital, Universita Cattolica del Sacro Cuore, Rome, Italy
    Eur Respir J Suppl 42:22s-26s. 2003
    ....
  48. ncbi Diminished lung compliance and elevated surfactant lipids and proteins in nutritionally obese young rats
    L S Inselman
    Department of Pediatrics, Division of Pulmonology, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, Delaware 19899, USA
    Lung 182:101-17. 2004
    ..This suggests that alterations in lung compliance and surfactant content may also occur...
  49. ncbi Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice
    T Glaab
    Department of Respiratory Medicine, Hannover Medical School, 30625 Hannover, Germany
    Am J Physiol Lung Cell Mol Physiol 280:L565-73. 2001
    ..We conclude that measurement of EF(50) to inhaled bronchoconstrictors by head-out body plethysmography is a valid measure of airway hyperresponsiveness in mice...
  50. ncbi Airway-parenchyma uncoupling in nocturnal asthma
    C G Irvin
    Pulmonary Disease and Critical Care Medicine, Molecular Physiology and Biophysics, University of Vermont, Colchester, Vermont 05446, USA
    Am J Respir Crit Care Med 161:50-6. 2000
    ..Indirect measurements of lung compliance were consistent with a stiffening of the lung...
  51. ncbi Lung recruitment and breathing pattern during variable versus continuous flow nasal continuous positive airway pressure in premature infants: an evaluation of three devices
    S E Courtney
    Robert Wood Johnson Medical School at Camden and the Department of Pediatrics, Division of Neonatology, the Children s Regional Hospital at Cooper Hospital University Medical Center, Camden, New Jersey 08103, USA
    Pediatrics 107:304-8. 2001
    ..To determine whether lung volume changes and breathing pattern parameters differ among 3 devices for delivery of nasal continuous positive airway pressure (CPAP) in premature infants...
  52. ncbi Regional distribution of gas and tissue in acute respiratory distress syndrome. III. Consequences for the effects of positive end-expiratory pressure. CT Scan ARDS Study Group. Adult Respiratory Distress Syndrome
    L Puybasset
    Reanimation Chirurgicale Pierre Viars, Department of Anesthesiology, Hopital de la Pitie Salpetriere, University of Paris Pierre et Marie Curie, France
    Intensive Care Med 26:1215-27. 2000
    ..To determine whether differences in lung morphology assessed by computed tomography (CT) affect the response to positive end-expiratory pressure (PEEP)...
  53. ncbi Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia-reperfusion injury of the lung
    Takayuki Nakamura
    Department of Thoracic and Cardiovascular Surgery, University of Saarland, 66421 Homburg and Saarbrücken, Germany
    J Heart Lung Transplant 24:38-45. 2005
    ..However, the effect of this approach on alveolar macrophages in pulmonary ischemia-reperfusion injury has not yet been evaluated...
  54. pmc Clinical review: bedside assessment of alveolar recruitment
    Jean Christophe Richard
    Medical Intensive Care Unit, Rouen University Hospital, Rouen, France
    Crit Care 8:163-9. 2004
    ..We also describe alternate techniques that have been proposed to assess recruitment at the bedside. Whether recruitment should be optimized remains an ongoing controversy that warrants further clinical investigation...
  55. ncbi Mechanical ventilation effect on surfactant content, function, and lung compliance in the newborn rat
    Francisco Martinez
    Department of Pediatics, University of Toronto, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Pediatr Res 56:19-25. 2004
    ..Yet, there is evidence that, in neonates, ventilation with a higher than physiologic TV leads to improved lung compliance. The purpose of our study was to evaluate how lung compliance and surfactant was altered by high TV ..
  56. ncbi PEEP decreases atelectasis and extravascular lung water but not lung tissue volume in surfactant-washout lung injury
    Thomas Luecke
    Department of Anesthesiology and Critical Care Medicine, Faculty of Clinical Medicine, University Hospital, Theodor Kutzer Ufer, 68167, Mannheim, Germany
    Intensive Care Med 29:2026-33. 2003
    ..To examine the effects of positive end-expiratory pressure (PEEP) on extravascular lung water (EVLW), lung tissue, and lung volume...
  57. ncbi Positive pressure ventilation with the open lung concept optimizes gas exchange and reduces ventilator-induced lung injury in newborn piglets
    Anton H van Kaam
    Department of Neonatology, Emma Children s Hospital AMC, University of Amsterdam, The Netherlands
    Pediatr Res 53:245-53. 2003
    ..001). Maximal lung compliance was superior in both OLC groups (PPV(OLC): 91 +/- 23; HFOV(OLC): 90 +/- 31 mL/kPa/kg, p < 0...
  58. ncbi Repeated derecruitments accentuate lung injury during mechanical ventilation
    Gee Young Suh
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Korea
    Crit Care Med 30:1848-53. 2002
    ..This study was performed to test the hypothesis that derecruitment itself might accentuate lung injury during mechanical ventilation...
  59. ncbi Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response
    S M Fiser
    Department of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 121:1069-75. 2001
    ..By using the macrophage inhibitor gadolinium chloride and leukocyte filters, we attempted to identify the roles of these two populations of cells in lung transplant reperfusion injury...
  60. ncbi Improvements in lung compliance after pulmonary transplantation: correlation with interleukin 8 expression
    Jagan N Rao
    Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK
    Eur J Cardiothorac Surg 23:497-502. 2003
    ..We investigated three pharmacological agents in a porcine model of left single lung transplantation to determine the effect on lung compliance and its relationship with the expression of the cytokine, interleukin-8 (IL-8).
  61. pmc Surfactant application during extracorporeal membrane oxygenation improves lung volume and pulmonary mechanics in children with respiratory failure
    Michael Hermon
    Division of Neonatology and Pediatric Intensive Care, University Children s Hospital, Medical University of Vienna, Austria
    Crit Care 9:R718-24. 2005
    ....
  62. pmc Effect of lung compliance and endotracheal tube leakage on measurement of tidal volume
    Sami I Al-Majed
    Pediatric pulmonary and Intensive Care, Dhahran Health Center, Saudi Aramco, Saudi Arabia
    Crit Care 8:R398-402. 2004
    The objective of this laboratory study was to measure the effect of decreased lung compliance and endotracheal tube (ETT) leakage on measured exhaled tidal volume at the airway and at the ventilator, in a research study with a test lung.
  63. ncbi Temporal change, reproducibility, and interobserver variability in pressure-volume curves in adults with acute lung injury and acute respiratory distress syndrome
    Sangeeta Mehta
    Interdepartmental Divison of Critical Care Medicine, University of Toronto, and Mount Sinai Hospital, ON, Canada
    Crit Care Med 31:2118-25. 2003
    ....
  64. ncbi Postnatal lung mechanics, lung composition, and surfactant synthesis after tracheal occlusion vs prenatal intrapulmonary instillation of perfluorocarbon in fetal rabbits
    Oliver J Muensterer
    Department of Pediatric Surgery, Dr von Hauner Children s Hospital, University of Munich, 80337 Munich, Germany
    J Pediatr Surg 40:26-31. 2005
    ..This study compares neonatal lung mechanics and surfactant production after prenatal intrapulmonary PFOB instillation vs TO...
  65. ncbi Detection of partial endotracheal tube obstruction by forced pressure oscillations
    Stefan Schumann
    Section for Experimental Anesthesiology, University Hospital of Freiburg, Germany
    Respir Physiol Neurobiol 155:227-33. 2007
    ..In volunteers, a similar reduction (10.9%) was found when 5 ml fluid were applied. We conclude that analysis of pressure oscillations after flow interruption offers a tool for non-invasive detection of partial ETT obstruction...
  66. ncbi [Mechanical ventilation in acute respiratory distress syndrome (ARDS): lung protecting strategies for improved alveolar recruitment]
    M J Schultz
    Laboratorium Experimentele Geneeskunde, Academisch Medisch Centrum Universiteit van Amsterdam, afd Intensive Care Volwassenen, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 147:327-31. 2003
    ..The best PEEP level is that with which the largest improvement in oxygen transport and lung compliance is achieved, without a decrease in the stroke volume of the left ventricle...
  67. ncbi Alveolar inflation during generation of a quasi-static pressure/volume curve in the acutely injured lung
    Henry J Schiller
    Departments of Surgery, SUNY Upstate Medical University, Syracuse, NY, USA
    Crit Care Med 31:1126-33. 2003
    ..In this study, we visualized the inflation of individual alveoli during the generation of a pressure/volume curve by direct visualization using in vivo microscopy in a surfactant deactivation model of lung injury in pigs...
  68. ncbi Measuring end-expiratory lung volume and pulmonary mechanics to detect early lung function impairment in rabbits
    Walid Habre
    Pediatric Anesthesia Unit, Geneva Children s Hospital, Switzerland
    Respir Physiol Neurobiol 152:72-82. 2006
    ....
  69. ncbi A mechanistic model for quasistatic pulmonary pressure-volume curves for inflation
    R Amini
    Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02115, USA
    J Biomech Eng 127:619-29. 2005
    ....
  70. ncbi Alveolar pressure monitoring: an evaluation in a lung model and in patients with acute lung injury
    S Sondergaard
    Department of Anaesthesia and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden
    Intensive Care Med 29:955-62. 2003
    ..The algorithm is based on "static" pressure/volume curves obtained from tracheal pressure measurements under dynamic conditions...
  71. ncbi Prenatal nicotine exposure transiently alters the lung mechanical response to hypoxia in young lambs
    Kenneth L Sandberg
    Department of Women and Child Health, Goteborg University, SE 416 85 Goteborg, Sweden
    Respir Physiol Neurobiol 156:283-92. 2007
    ..We speculate that prenatal nicotine-induced alterations of lung mechanics during hypoxia may contribute to an increased vulnerability to hypoxic stress during infancy...
  72. ncbi Time and tidal volume-dependent ventilator-induced lung injury in healthy rats
    B Walder
    University Hospitals of Geneva, Division of Anaesthiological Investigations, Geneva, Switzerland
    Eur J Anaesthesiol 22:785-94. 2005
    ..We evaluated the effect of duration of mechanical ventilation with different tidal volumes (VT) on ventilator-induced lung injury in healthy rats...
  73. ncbi Effect of thoracentesis on respiratory mechanics and gas exchange in the patient receiving mechanical ventilation
    Peter Doelken
    Division of Pulmonary and Critical Care Medicine 7D, Beth Israel Medical Center, New York, NY 10003, USA
    Chest 130:1354-61. 2006
    ..This study reports the effect of thoracentesis on respiratory mechanics and gas exchange in patients receiving mechanical ventilation. Study design: Prospective...
  74. ncbi The esophageal-tracheal combitube resistance and ventilatory pressures
    Luis A Gaitini
    Department of Anesthesiology, B nai Zion Medical Center, Haifa 31048, Israel
    J Clin Anesth 17:26-9. 2005
    ..To measure resistance of the Combitube, a supraglottic ventilatory device used in the management of the patients with difficult airways, and its influence on delivered ventilatory pressures...
  75. ncbi Influence of respiratory efforts on b2-agonist induced bronchodilation in mechanically ventilated COPD patients: a prospective clinical study
    P Malliotakis
    Intensive Care Medicine Department, University Hospital of Heraklion, University of Crete, Heraklion, 71110 Crete, Greece
    Respir Med 101:300-7. 2007
    ..However, the influence of active respiratory efforts on the magnitude of b2-agonist induced bronchodilation in mechanically ventilated patients has not been examined...
  76. ncbi Nonlinear and frequency-dependent mechanical behavior of the mouse respiratory system
    Henrique T Moriya
    Vermont Lung Center, Department of Medicine and Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405 0075, USA
    Ann Biomed Eng 31:318-26. 2003
    ..This model may be useful for detecting overinflation of the lung during mechanical ventilation...
  77. ncbi Continuous tracheal gas insufflation during partial liquid ventilation in juvenile rabbits with acute lung injury
    Guangfa Zhu
    Department of Respiratory Medicine, Shanghai First People s Hospital, Shanghai, China
    J Appl Physiol 96:1415-24. 2004
    ..either treatment alone. These results indicate that combined treatment of TGI and PLV results in improved pulmonary outcome than either treatment alone in this animal model of ALI...
  78. ncbi An improved technique for repeated bronchoalveolar lavage and lung mechanics measurements in individual rats
    Zoltan Novak
    Department of Pediatrics, University of Szeged, Szeged, Hungary Svábhegy Pediatric Institute, Budapest, Hungary
    Respir Physiol Neurobiol 154:467-77. 2006
    ..We conclude that longitudinal follow-up of the airway and tissue mechanics and inflammatory cells in the BAL fluid are feasible in rats. The current method allows an early detection of lung injury, even in a relatively mild form...
  79. ncbi Positive end-expiratory pressure prevents lung mechanical stress caused by recruitment/derecruitment
    Luciana L Farias
    Laboratory of Respiration Physiology, Instituto de Biofisica Carlos Chagas Filho CCS, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Ilha do Fundao, 21949 900 Rio de Janeiro, Brazil
    J Appl Physiol 98:53-61. 2005
    ..Ventilation with 5-cmH(2)O PEEP prevented derecruitment and aborted the increase in PCIII expression...
  80. ncbi The issue of dynamic hyperinflation in acute respiratory distress syndrome patients
    A Vieillard-Baron
    Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, Boulogne, France
    Eur Respir J Suppl 42:43s-47s. 2003
    ....
  81. pmc Respiratory compliance but not gas exchange correlates with changes in lung aeration after a recruitment maneuver: an experimental study in pigs with saline lavage lung injury
    Dietrich Henzler
    Anesthesiology Department, University Hospital RWTH Aachen, Germany
    Crit Care 9:R471-82. 2005
    ..The aim of this study was to investigate whether commonly used measures of lung mechanics better detect lung tissue collapse and changes in lung aeration after a recruitment maneuver as compared to measures of gas exchange..
  82. ncbi Desmin modulates lung elastic recoil and airway responsiveness
    Felix R Shardonofsky
    University of Texas Southwestern Medical Center, Department of Pediatrics, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Lung Cell Mol Physiol 290:L890-6. 2006
    ..We hypothesized that desmin modulates lung compliance, lung recoil pressure, and airway contractile response...
  83. ncbi Choosing the frequency of deep inflation in mice: balancing recruitment against ventilator-induced lung injury
    Gilman B Allen
    Vermont Lung Center, Department of Medicine, University of Vermont, Fletcher Allen Health Care, Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 291:L710-7. 2006
    ..Differences between LVDI and HV suggest that an optimal frequency range of DI exists, within which the benefits of maintaining an open lung outweigh injury incurred from overdistention...
  84. ncbi Early patterns of static pressure-volume loops in ARDS and their relations with PEEP-induced recruitment
    Antoine Vieillard-Baron
    Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9 avenue Charles de Gaulle, 92104, Boulogne Cedex, France
    Intensive Care Med 29:1929-35. 2003
    ..Evaluation of low-flow pressure-volume loop at the bedside in ARDS, as an aid to assess recruitment produced by PEEP...
  85. ncbi Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury
    James A Frank
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Crit Care Med 33:181-8; discussion 254-5. 2005
    ..The primary objective of this study was to determine the effect of one type of recruitment maneuver--sustained inflation--on alveolar epithelial and lung endothelial injury in experimental acute lung injury...
  86. ncbi Measurement of changes in respiratory mechanics during partial liquid ventilation using jet pulses
    Gerd Schmalisch
    Clinic of Neonatology Charité, Humboldt University Berlin, Germany
    Crit Care Med 31:1435-41. 2003
    ..To compare the changes in respiratory mechanics within the breathing cycle in healthy lungs between gas ventilation and partial liquid ventilation using a special forced-oscillation technique...
  87. ncbi Effects of sustained inflation and postinflation positive end-expiratory pressure in acute respiratory distress syndrome: focusing on pulmonary and extrapulmonary forms
    Simru Tugrul
    Anesthesiology Department, Istanbul Medical Faculty, Turkey
    Crit Care Med 31:738-44. 2003
    ..To investigate whether the response to sustained inflation and postinflation positive end-expiratory pressure varies between acute respiratory distress syndrome with pulmonary (ARDS(exp)) and extrapulmonary origin (ARDS(exp))...
  88. ncbi A decremental PEEP trial for determining open-lung PEEP in a rabbit model of acute lung injury
    Yi Ming Hua
    Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Pediatr Pulmonol 43:371-80. 2008
    ..This strategy could be used as an indicator for optimal PEEP. The approach is simple and noninvasive and may be of clinical interest...
  89. ncbi "Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease"
    Jeffrey J Fredberg
    J Appl Physiol 103:1905; author reply 1909-10. 2007
  90. ncbi Effect of PEEP on induced constriction is enhanced in decorin-deficient mice
    Francesco G Salerno
    Respiratory Unit, University of Foggia and Fondazione Salvatore Maugeri, Cassano Murge, BA Italy
    Am J Physiol Lung Cell Mol Physiol 293:L1111-7. 2007
    ..These results show that lack of Dcn alters the normal interaction between airways and lung parenchyma; in asthma, changes in Dcn could potentially contribute to abnormal airway physiology...
  91. ncbi Partial liquid ventilation in severely surfactant-depleted, spontaneously breathing rabbits supported by proportional assist ventilation
    U H Thome
    Division of Neonatology and Pediatric Critical Care, University Children's Hospital, 89070 Ulm, Germany
    Crit Care Med 29:1175-80. 2001
    ..CONCLUSIONS: PLV improved oxygenation and pulmonary compliance in spontaneously breathing, severely surfactant-depleted rabbits supported by PAV. The severity of lung injury by histology was unaffected...
  92. ncbi A recruitment manoeuvre performed after endotracheal suction does not increase dynamic compliance in ventilated paediatric patients: a randomised controlled trial
    Brenda Morrow
    University of Cape Town, South Africa
    Aust J Physiother 53:163-9. 2007
    ..Does a recruitment manoeuvre after suctioning have any immediate or short-term effect on ventilation and gas exchange in mechanically-ventilated paediatric patients?..
  93. ncbi Circuit compliance compensation in lung protective ventilation
    Grazia Maria Pia Masselli
    Faculty of Biomedical Engineering, University Campus Bio Medico of Rome, Italy
    Conf Proc IEEE Eng Med Biol Soc 1:5603-6. 2006
    ..Differences between volume and pressure controlled ventilation are also quantitatively assessed showing that pressure controlled ventilation allows a more reliable compensation of breathing circuit compressible volume...
  94. ncbi Cytokine release, small airway injury, and parenchymal damage during mechanical ventilation in normal open-chest rats
    Edgardo D'Angelo
    Istituto di Fisiologia Umana I, Milan, Italy
    J Appl Physiol (1985) 104:41-9. 2008
    ..Enhanced small airway epithelial damage with induced surfactant dysfunction or MV on NEEP can, however, contribute to cytokine production...
  95. ncbi Leak compensation in positive pressure ventilators: a lung model study
    S Mehta
    Mt Sinai Hospital, University of Toronto, Canada
    Eur Respir J 17:259-67. 2001
    ..Adequate inspiratory flows and durations should be used, triggering sensitivity should be adjusted to prevent autocycling, and a mechanism should be available to limit inspiratory time and avoid I:E ratio inversion...
  96. ncbi Counterpoint: lung impedance measurements are not more useful than simpler measurements of lung function in animal models of pulmonary disease
    Wayne Mitzner
    J Appl Physiol 103:1901-3; discussion 1903-4. 2007
  97. ncbi "Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease"
    J Craig Cohen
    J Appl Physiol 103:1905-8; author reply 1909-10. 2007
  98. ncbi "Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease"
    DARRYL ZELDIN
    J Appl Physiol 103:1906; author reply 1909-10. 2007
  99. ncbi "Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease"
    Bela Suki
    J Appl Physiol 103:1906-7; author reply 1909-10. 2007
  100. ncbi "Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease"
    David W Kaczka
    J Appl Physiol 103:1907; author reply 1909-10. 2007
  101. ncbi "Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease"
    Lennart K A Lundblad
    J Appl Physiol 103:1907-8; author reply 1909-10. 2007

Research Grants62

  1. TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNG
    Namasivayam Ambalavanan; Fiscal Year: 2012
    ..muscle actin, interstitial collagen, tissue lung resistance (but normal airway resistance), and decreased lung compliance, demonstrating that absence of Thy-1 in the developing lung leads to a lung phenotype similar to ..
  2. Neonatal Oxygen and Susceptibility to Respiratory Viral Infections
    MICHAEL A O'REILLY; Fiscal Year: 2013
    ..Like children born prematurely, adult mice exposed to high oxygen (hyperoxia) as newborns had altered lung compliance that was attributed to increased alveolar simplification and disrupted epithelial cell differentiation...
  3. Mesenchymal Cell Fate Determination by Extracellular Matrix Stiffness
    Jeffrey C Horowitz; Fiscal Year: 2013
    ..the effects of soluble mediators on mesenchymal cell apoptosis;and (3) determine the relationship between lung compliance, fibrogenesis, and mesenchymal cell accumulation...
  4. Regulatory Tcells and the fibroproliferative response in Acute Lung Injury
    Brian Garibaldi; Fiscal Year: 2011
    ..stage marked pathologically by fibrosis and clinically by increasing dead space, decreasing lung compliance and worsening oxygenation...
  5. Cardiolipin Induced Lung Injury and FIC1
    Rama K Mallampalli; Fiscal Year: 2013
    ..Further, CL potently elevates lung surface- tension and impairs lung compliance. These original observations suggest a new role for CL as an important mediator of acute and chronic ..
  6. TRP Channels and Air Pollution
    Christopher A Reilly; Fiscal Year: 2013
    ..Neuronal stimulation and subsequent reduction in lung compliance elicited by DEP are inhibited by the TRPA1 antagonist HC-030031, and both neurons and bronchial epithelial ..
  7. Structure/Function Analyses Of SP-B
    TIMOTHY EDWARD WEAVER; Fiscal Year: 2010
    ..of SP-Bresults in lethal, neonatal respiratory distress syndrome and is characterized by a virtual absence of lung compliance, highly disorganized lamellar bodies and greatly diminished levels of SP-C mature peptide...
  8. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    ..The third aim is to test the hypothesis the increase in connective tissue and lung fluid will decrease lung compliance and increase lung resistance to airflow...
  9. LUNG AND AIRWAY AFFERENTS AND THEIR REFLEX ROLE
    JOHN COLERIDGE; Fiscal Year: 1992
    ..five main objectives: 1) To further explore the response of rapidly adapting receptors (RARs) to changes in lung compliance (CDYN); and to examine the hypothesis that stimulation of RARs by decreasing CDYN is due to their specific ..
  10. THORACOABDOMINAL ASYNCHRONY IN INFANT AIRWAY OBSTRUCTION
    Julian Allen; Fiscal Year: 1992
    ..It results in multiple abnormalities of lung mechanics, e.g., decreased lung compliance and increased airway resistance and work of breathing...
  11. Bronchial Angiogenesis in the Ischemic Lung
    Adlah Sukkar; Fiscal Year: 2007
    ..We will measure bronchial vascular permeability and its affect on lung compliance and resistance at time points before and after the new vasculature is established...
  12. Development of Hyperpolarized Helium for Assessing ILD
    Milton Rossman; Fiscal Year: 2009
    ..optimize and assess the reproducibility of the three regional measurement techniques (regional alveolar size, lung compliance, and alveolar oxygen levels) using HP helium MRI in healthy rats Specific Aim 2:A...
  13. CARDIOPULMONARY REFLEXES IN HEART FAILURE
    Irving Zucker; Fiscal Year: 2001
    ..2) If augmented input from vagal pulmonary afferents (which may be stimulated by pulmonary edema, changes in lung compliance or local humoral mediators) are, in part, responsible for the depression in baroreflex sensitivity known to ..
  14. DESIGN AND TRANSGENIC ANALYSIS OF CELLULAR INHIBITORS
    JOHN DEDMAN; Fiscal Year: 2003
    ..It is anticipated that unique mouse lines will be developed that have altered lung compliance, mucous congestion and lung fibrosis...
  15. The role of sphingosine-1-phosphate in acute lung injury
    BRYAN MCVERRY; Fiscal Year: 2004
    ..In doing so, we will quantify shunt fraction, alveolar dead space fraction, lung compliance, lung edema formation, and alveolar barrier permeability...
  16. MECHANICS OF ACUTE LUNG INJURY
    Jason Bates; Fiscal Year: 2009
    ..The results of our studies are expected to lead to the design of physiologically-based lung recruitment strategies that can be tailored to the individual patient with ALI. This will set the stage for future clinical trials. ..
  17. Assessment of Lung function in Mice
    Jason Bates; Fiscal Year: 2009
    ....
  18. AIRWAY PERFUSION ASSISTED LIQUID VENTILATOR
    James Parker; Fiscal Year: 2002
    ..Other applications include continuous intrapulmonary administration of drugs and anesthetics and clearance of material from the lungs...
  19. Airway as Target Organ in Infants with Atopic Dermatitis
    Robert Tepper; Fiscal Year: 2008
    ..Specific Aim # 2: Evaluate whether the presence of phenotypic characteristics of the asthmatic airway identifies infants and toddlers that develop clinical asthma by 5 years of age. [unreadable] [unreadable]..
  20. Phase II validation of 4-dimensional computed tomography derived ventilation for
    Thomas Guerrero; Fiscal Year: 2008
    ..Our new imaging method uses equipment already available in almost every radiation oncology clinic. This study seeks to validate our new ventilation imaging with the present standard method. [unreadable] [unreadable] [unreadable]..
  21. GROWTH OF AIRWAYS AND LUNG PARENCHYMA IN NORMAL INFANTS
    Robert Tepper; Fiscal Year: 2009
    ..abstract_text> ..
  22. MONOCLONAL ANTIBODIES FOR THE STUDY OF P. CARINII
    Francis Gigliotti; Fiscal Year: 2009
    ..We will also determine the microbiologic effect of combining passive antibody therapy with conventional antimicrobial therapy. ..
  23. TRPV4 Initiates Ventilator Induced Lung Injury
    James C Parker; Fiscal Year: 2010
    ..and that lung PAR1 and PAR2 activation peptidesincrease lung vascular permeability in TRPV4+/+ mice ventilated with high airway pressures but not in TRPV4-/- mice, or either genotype ventilated with low airway pressures ..
  24. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..abstract_text> ..
  25. ROLE OF SURFACTANT PROTEIN D IN SURFACTANT HOMEOSTASIS
    Machiko Ikegami; Fiscal Year: 2006
    ..The intended studies will provide fundamental insights into the role of SP-D in the protection of the lung, as well as into the basic mechanisms determining surfactant homeostasis. ..
  26. Mechanical Injury to Lung Endothelium
    James Parker; Fiscal Year: 2001
    ....
  27. P CARINII PNEUMONIA--IMMUNOPATHOGENESIS OF LUNG INJURY
    Francis Gigliotti; Fiscal Year: 2001
    ..Using the most modem molecular/cellular and physiologic techniques, including assessment of lung compliance in a ventilated living mouse, this proposal will test the hypothesis that the pathogenesis of PCP is the ..
  28. Host response to post-operative pneumonia
    Paul Knight; Fiscal Year: 2005
    ....
  29. Physiology of Respiratory Muscle Micromechanics
    ALADIN BORIEK; Fiscal Year: 2009
    ..The completion of these aims will significantly contribute to the fundamental understanding of mechanical signal transduction in the respiratory pump. ..
  30. Veterinary Comparative Respiratory Society 2008 Symposium
    Michael Davis; Fiscal Year: 2008
    ..This symposium will review the current knowledge and practical challenges of these models in order to make them more accessible to the biomedical research community. [unreadable] [unreadable] [unreadable]..
  31. Translational Research in Lung Biology
    Charles Irvin; Fiscal Year: 2009
    ..The institution listed is for the Center, which is not necessarily the institution for the investigator. For studies to help set the stage for gaining a better understanding of lung disease pathogenesis. ..
  32. P CARINII-EPITHELIAL INTERACTIONS MEDIATE INFLAMMATION
    Terry Wright; Fiscal Year: 2003
    ..The goal of this proposal is to understand the inflammatory response to P. carinii so that strategies may be developed to circumvent the lung injury that results from the host response to P. carinii. ..
  33. CONTROL OF BREATHING PATTERN AND RHYTHM
    DONALD MC CRIMMON; Fiscal Year: 2002
    ..Identification of the neuronal pathways producing respiratory rhythm and pattern are prerequisite for full understanding of a variety of clinical disorders such as sleep apnea and central hypoventilation syndrome. ..
  34. INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASE
    John Kinsella; Fiscal Year: 2004
    ..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..
  35. 1-Cys-peroxiredoxin, A Novel Lung Anti-oxidant Enzyme
    Aron Fisher; Fiscal Year: 2004
    ..These studies will give insights into the function and antioxidant activity of this potentially important, newly described enzyme. ..
  36. Lateral Pontine Neurons in the Control of Breathing
    DONALD MC CRIMMON; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  37. Ventilation Improves Lung Physiology and Biology
    Bela Suki; Fiscal Year: 2006
    ..abstract_text> ..
  38. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2005
    ..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
  39. Biomechanical Evaluation of Eustachian Tube Dysfunction
    Samir N Ghadiali; Fiscal Year: 2010
    ..This information is vital to the development of novel treatment therapies that seek to restore normal ET function in patients with OM. ..
  40. Tumor Diagnosis through Enhanced Ultrasound Imaging
    Michael Oelze; Fiscal Year: 2003
    ..6. Several techniques for combining typical ultrasound images with the quantification of tissue microstructures will be evaluated for facilitation of clinical detection and diagnosis of disease. ..
  41. Pneumografting - a novel cell-based therapy for emphysema
    Edward P Ingenito; Fiscal Year: 2010
    ..We intend to advance this approach, known as pneumografting, into human trials under a physician-sponsored Investigation New Drug Application. ..
  42. High Frequency Oscillatory Ventilation in ARDS
    David Hager; Fiscal Year: 2005
    ..abstract_text> ..
  43. RESPIRATORY SYSTEM MECHANICS
    ALADIN BORIEK; Fiscal Year: 2002
    ....
  44. TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURY
    MICHAEL O REILLY; Fiscal Year: 2002
    ..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..
  45. SYMPTOM PERCEPTION IN CRITICAL ADOLESCENT ASTHMA
    Anthony Mansell; Fiscal Year: 2004
    ..The proposed research is expected to advance the understanding of perceptual abnormalities as risk factors for LTA and to help clinicians identify those adolescents at risk of a life-threatening asthma exacerbation. ..
  46. ANIMAL MODELS OF COLD AIR-INDUCED AIRWAY DISEASE
    Michael Davis; Fiscal Year: 2004
    ..The investigators will use these same measurements to determine the changes in pulmonary mechanics and airway inflammation in dogs that perform repeated exercise in frigid environments. ..
  47. Development of a Novel Gas Embolotherapy Technique
    JOSEPH BULL; Fiscal Year: 2005
    ..The proposed research is an essential first step in developing this potentially revolutionary technique. ..
  48. Improving Respiratory Outcomes in ALS
    Noah Lechtzin; Fiscal Year: 2006
    ..To this end, we propose three related studies: a) an investigation of the immediate effect of NIPPV on lung compliance; b) a randomized trial of NIPPV in patients with mild respiratory muscle weakness; and c) a cohort study ..
  49. Exercise and Vascular Function in Paraplegic
    STEPHEN DICARLO; Fiscal Year: 2006
    ..The clinical significance of the post-exercise modulation of vascular function will be determined by the evaluating the cardiovascular and sympathetic nerve responses to colon distension. ..
  50. PreBotzinger Circuit in Respiratory Rhythm Generation
    DONALD MC CRIMMON; Fiscal Year: 2007
    ..The hypothesis to be addressed is that the neuronal types and synaptic interactions within the preB6tzinger complex are sufficient for respiratory rhythm generation in vivo. ..
  51. Force Propagation of Emphysema in Vivo
    Edward Ingenito; Fiscal Year: 2007
    ..The results of these experiments will provide new insight into the role of mechanical forces in promoting injury in the intact emphysema lung, and the effect of mechanical forces on tissue remodeling. [unreadable] [unreadable]..
  52. Engineering Approach to the Ventilatory Pump
    ALADIN BORIEK; Fiscal Year: 2007
    ..The completion of these aims will significantly enhance our fundamental understanding of the ventilatory pump function in health and disease. [unreadable] [unreadable]..
  53. Chemokines in lung transplantation
    BENJAMIN MEDOFF; Fiscal Year: 2007
    ..abstract_text> ..
  54. BioMediator: Biologic Data Integration& Analysis System
    Peter Tarczy Hornoch; Fiscal Year: 2005
    ..abstract_text> ..
  55. Structure-Function Relationships in Lung Surfactants
    Joanna Long; Fiscal Year: 2008
    ..We will be using novel, sensitive solid state NMR experiments which allow us to determine at atomic resolution these parameters at low concentrations in complex lipid environments. ..
  56. Airway Reactivity and Heterogeneity in Asthma
    Kenneth Lutchen; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  57. 2008 Biology of Acute Respiratory Infections Gordon Research Conference
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  58. Asthma Exacerbations: physiology, upper airway & fibrin
    Charles Irvin; Fiscal Year: 2008
    ..Such information may ultimately lead to new therapeutic strategies. (End of Abstract) [unreadable] [unreadable]..
  59. POST BMT LUNG INJURY PATHOPHYSIOLOGY
    Angela Panoskaltsis Mortari; Fiscal Year: 2009
    ..These translatable approaches offer new avenues for the prevention and treatment of IPS. ..
  60. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
  61. Role of TGF-Alpha in Pulmonary Vascular Disease
    TIMOTHY LE CRAS; Fiscal Year: 2006
    ..This information will serve as a basis for developing therapeutic strategies aimed at improving lung growth and preventing pulmonary hypertension in premature babies and adults. ..