bronchial provocation tests

Summary

Summary: Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.

Top Publications

  1. pmc The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline
    John D Brannan
    Department of Respiratory Medicine, 11 West, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Respir Res 6:144. 2005
  2. ncbi Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model
    Gang Cheng
    Department of Pulmonary Medicine, Dokkyo University School of Medicine, Mibu machi, Shimotsuga gun, Tochigi 321 0293, Japan
    Am J Respir Crit Care Med 166:409-16. 2002
  3. ncbi Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma
    Dave Singh
    Medicines Evaluation Unit, South Manchester University Hospitals Trust, University of Manchester, Manchester, United Kingdom
    Am J Respir Crit Care Med 176:988-93. 2007
  4. ncbi Occupational asthma due to chromium and nickel salts
    Mar Fernández-Nieto
    Department of Allergy, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Av Reyes Católicos, 2, 28040 Madrid, Spain
    Int Arch Occup Environ Health 79:483-6. 2006
  5. pmc Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae)
    E S Schelegle
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Pathol 158:333-41. 2001
  6. ncbi Mechanical effects of obesity on airway responsiveness in otherwise healthy humans
    Roberto Torchio
    Pneumologia Fisiopatologia Respiratoria, Azienda Ospedaliera S Luigi, Torino, Italy
    J Appl Physiol (1985) 107:408-16. 2009
  7. pmc Reference values for methacholine reactivity (SAPALDIA study)
    Pierre Yves Jayet
    Service of Pulmonology, University Hospital Lausanne, Switzerland
    Respir Res 6:131. 2005
  8. ncbi Peripheral blood gene expression changes during allergen inhalation challenge in atopic asthmatic individuals
    Sarah H Y Kam
    James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    J Asthma 49:219-26. 2012
  9. ncbi Effects of chest wall strapping on mechanical response to methacholine in humans
    Roberto Torchio
    Pneumologia Fisiopatologia Respiratoria, Azienda Ospedaliera S Croce e Carle, Ospedale A Carle, Via Carle, 12100 Confreria Cuneo, Italy
    J Appl Physiol 101:430-8. 2006
  10. pmc Reproducibility of non-specific bronchial challenge in adults: implications for design, analysis and interpretation of clinical and epidemiological studies
    S Chinn
    Department of Public Health Sciences, King s College London, London SE1 3QD, UK
    Thorax 60:395-400. 2005

Research Grants

  1. Assessment of Lung function in Mice
    Jason Bates; Fiscal Year: 2009
  2. MECHANICS OF ACUTE LUNG INJURY
    Jason Bates; Fiscal Year: 2009
  3. The Genetic Epidemiology of Asthma in Costa Rica
    JUAN CELEDON; Fiscal Year: 2005
  4. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John P Capitanio; Fiscal Year: 2010
  5. Airway Biology of Acute Asthma: Translational Studies
    David Peden; Fiscal Year: 2008
  6. The Effect of Mycoplasma on Chronic Asthma
    Richard Martin; Fiscal Year: 2008
  7. Maternal Influence in the Development of Asthma
    Edward Barrett; Fiscal Year: 2008
  8. Mechanisms of HSF1-mediated Repression of TNF-alpha
    Jeffrey Hasday; Fiscal Year: 2007
  9. Towards a better understanding of work-aggravated asthma
    Catherine Lemiere; Fiscal Year: 2009
  10. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2006

Detail Information

Publications252 found, 100 shown here

  1. pmc The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline
    John D Brannan
    Department of Respiratory Medicine, 11 West, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Respir Res 6:144. 2005
    ..The safety and the efficacy of mannitol (M) as a BPT to measure airway hyperresponsiveness were compared to hypertonic (4.5%) saline (HS) in people both with and without signs and symptoms of asthma...
  2. ncbi Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model
    Gang Cheng
    Department of Pulmonary Medicine, Dokkyo University School of Medicine, Mibu machi, Shimotsuga gun, Tochigi 321 0293, Japan
    Am J Respir Crit Care Med 166:409-16. 2002
    ..Taken together, our findings emphasize the importance of IL-9 in the pathogenesis of asthma and suggest that blockade of IL-9 may be a new therapeutic strategy for bronchial asthma...
  3. ncbi Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma
    Dave Singh
    Medicines Evaluation Unit, South Manchester University Hospitals Trust, University of Manchester, Manchester, United Kingdom
    Am J Respir Crit Care Med 176:988-93. 2007
    ..Exhaled breath nitric oxide (Fe(NO)) is increased in asthma. NO is produced predominantly by inducible nitric oxide synthase (iNOS)...
  4. ncbi Occupational asthma due to chromium and nickel salts
    Mar Fernández-Nieto
    Department of Allergy, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Av Reyes Católicos, 2, 28040 Madrid, Spain
    Int Arch Occup Environ Health 79:483-6. 2006
    ..Exposure to chromium and nickel salts is a poorly characterized cause of occupational asthma...
  5. pmc Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae)
    E S Schelegle
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Pathol 158:333-41. 2001
    ..We conclude that a model of allergic asthma can be induced in rhesus monkeys using a protocol consisting of subcutaneous injection, intranasal instillation, and aerosol challenge with HDMA...
  6. ncbi Mechanical effects of obesity on airway responsiveness in otherwise healthy humans
    Roberto Torchio
    Pneumologia Fisiopatologia Respiratoria, Azienda Ospedaliera S Luigi, Torino, Italy
    J Appl Physiol (1985) 107:408-16. 2009
    ..In this study, airway hyperresponsiveness was significantly associated with obesity in otherwise healthy subjects. In obese men, but not in women, airway hyperresponsiveness was associated with the decreases in lung volumes...
  7. pmc Reference values for methacholine reactivity (SAPALDIA study)
    Pierre Yves Jayet
    Service of Pulmonology, University Hospital Lausanne, Switzerland
    Respir Res 6:131. 2005
    ..We derived reference equations depending on individual characteristics (i.e., sex, age, baseline lung function) for relevant percentiles of the methacholine two-point dose-response slope...
  8. ncbi Peripheral blood gene expression changes during allergen inhalation challenge in atopic asthmatic individuals
    Sarah H Y Kam
    James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    J Asthma 49:219-26. 2012
    ....
  9. ncbi Effects of chest wall strapping on mechanical response to methacholine in humans
    Roberto Torchio
    Pneumologia Fisiopatologia Respiratoria, Azienda Ospedaliera S Croce e Carle, Ospedale A Carle, Via Carle, 12100 Confreria Cuneo, Italy
    J Appl Physiol 101:430-8. 2006
    ..We speculate that breathing at low lung volumes induced by CWS enhances airway narrowing because the airway smooth muscle is adapted at a length at which the contractile apparatus is able to generate a force greater than normal...
  10. pmc Reproducibility of non-specific bronchial challenge in adults: implications for design, analysis and interpretation of clinical and epidemiological studies
    S Chinn
    Department of Public Health Sciences, King s College London, London SE1 3QD, UK
    Thorax 60:395-400. 2005
    ..The intraclass correlation coefficient measures loss of power and degree of bias. Information is lacking on the intraclass correlation coefficient for bronchial responsiveness and factors affecting reproducibility...
  11. ncbi IL-10 production in circulating T cells differs between allergen-induced isolated early and dual asthmatic responders
    Koichiro Matsumoto
    Asthma Research Group, St Joseph s Healthcare and McMaster University, Hamilton, Ontario, Canada
    J Allergy Clin Immunol 109:281-6. 2002
    ..Allergen inhalation by atopic asthmatic subjects results in 2 bronchoconstrictor phenotypes: isolated early response and dual response. Persistence of allergen-induced airway inflammation is a feature of dual responders...
  12. ncbi Changes in exhaled nitric oxide levels after bronchial allergen challenge
    Maria Pedrosa
    Department of Allergy, Hospital La Paz Health Research Institute, IdiPAZ, Madrid, Spain
    Lung 190:209-14. 2012
    ..The aim of this study was to assess airway inflammation with FeNO measurements during bronchial allergen challenge (BAC), and to determine the diagnostic performance of FeNO changes...
  13. ncbi Allergen inhalation challenge: a human model of asthma exacerbation
    Gail M Gauvreau
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Contrib Microbiol 14:21-32. 2007
    ....
  14. ncbi Short- and long-term reproducibility of capsaicin cough challenge testing
    Peter V Dicpinigaitis
    Department of Medicine, Albert Einstein College of Medicine, 1825 Eastchester Road, Bronx, NY 10461, USA
    Pulm Pharmacol Ther 16:61-5. 2003
    ..Short-term reproducibility of C(5) was superior to that of C(2), suggesting that C(5) is the preferred end point for trials involving serial cough challenges performed within a 14-day period...
  15. ncbi Equally elevated concentrations of exhaled nitric oxide in nonatopic and low-sensitized atopic asthmatics
    Heikki Ekroos
    Division of Clinical Physiology and Nuclear Medicine, Laboratory Department, Helsinki University Hospital, Helsinki, Finland
    Respir Med 103:152-8. 2009
    ..Some studies show concentrations of exhaled nitric oxide (FENO) in nonatopic asthma and in healthy subjects to be similar, but include asthmatics on inhaled steroids, which is likely to interfere with the results...
  16. ncbi Effect of n-3 polyunsaturated fatty acids in asthma after low-dose allergen challenge
    R Schubert
    Department of Pediatrics ZAFES, J W Goethe University, Frankfurt Main, Germany
    Int Arch Allergy Immunol 148:321-9. 2009
    ..We investigated the anti-inflammatory potential of n-3 polyunsaturated fatty acids (PUFA) on specific bronchial inflammation. Allergic asthmatics were challenged using a low-dose allergen provocation model...
  17. ncbi Methacholine and ovalbumin challenges assessed by forced oscillations and synchrotron lung imaging
    Sam Bayat
    Universite de Picardie Jules Verne, EA4285 Péritox INERIS and CHU Amiens, Amiens, France
    Am J Respir Crit Care Med 180:296-303. 2009
    ....
  18. ncbi Difference between dosimeter and tidal breathing methacholine challenge: contributions of dose and deep inspiration bronchoprotection
    Nathan D Allen
    Royal University Hospital, Department of Physiology, Division of Respirology, Critical Care and Sleep Medicine, 103 Hospital Dr, Ellis Hall, Room 551, Saskatoon, SK, S7N 0W8 Canada
    Chest 128:4018-23. 2005
    ..Both the lower dose and the bronchoprotective deep inhalations contribute to the lesser airway response of the dosimeter...
  19. ncbi Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling
    Ramzi Fattouh
    Department of Pathology and Molecular Medicine, Head, Division of Respiratory Diseases and Allergy, MDCL 4013, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
    Am J Respir Crit Care Med 177:593-603. 2008
    ..Transforming growth factor (TGF)-beta is a powerful regulator of both the tissue repair and inflammatory responses, and numerous experimental and clinical studies suggest that it may play an integral role in the pathogenesis of asthma...
  20. ncbi Direct assessment of small airways reactivity in human subjects
    E M Wagner
    Department of Medicine, The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 157:447-52. 1998
    ..However, the peripheral airways responsiveness was significantly enhanced in asthmatic subjects relative to normal controls...
  21. ncbi High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Respir Crit Care Med 163:994-1001. 2001
    ..Therefore, the mechanism for reduced bronchodilation after DIs in subjects with mild asthma could be intrinsic to the airway smooth muscle...
  22. ncbi Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases
    Jeroen A J Vanoirbeek
    Lung Toxicology Research Unit, Katholieke Universiteit Leuven, Herestraat 49 bus 706, Leuven, Belgium
    Am J Respir Cell Mol Biol 42:96-104. 2010
    ..Invasive pulmonary functions allow distinction between respiratory diseases in mice by clinically relevant variables, and should become standard in the functional evaluation of pathological disease models...
  23. ncbi Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice
    Barbro N Melgert
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Am J Respir Cell Mol Biol 30:880-5. 2004
    ..This effect of smoking may be different for long-term smoking, in which remodeling effects of smoking can be expected to interrelate with remodeling changes caused by asthmatic disease...
  24. ncbi Relation between occupational asthma case history, bronchial methacholine challenge, and specific challenge test in patients with suspected occupational asthma
    X Baur
    Institute for Occupational Medicine, BGFA, Ruhr University, Bochum, Germany
    Am J Ind Med 33:114-22. 1998
    ..In subjects with a positive occupational asthma case history, a negative MC test result can almost rule out a positive specific challenges test result. Hence, the MC test can reduce performance of the laborious specific challenge test...
  25. ncbi Sensitivity to methacholine and capsaicin in patients with unclear respiratory symptoms
    E Ternesten-Hasséus
    Asthma and Allergy Research Group, Department of Respiratory Medicine and Allergy, Sahlgrenska University Hospital, Gothenburg, Sweden
    Allergy 57:501-7. 2002
    ..Our aim was to study airway sensitivity to inhaled capsaicin and the occurrence of airway symptoms induced by strong scents in patients who underwent a bronchial methacholine test, primarily because of suspected asthma...
  26. ncbi Do mouse models of allergic asthma mimic clinical disease?
    Michelle M Epstein
    Department of Dermatology, University of Vienna, Vienna, Austria
    Int Arch Allergy Immunol 133:84-100. 2004
    ..the utility of mouse models for studying clinical manifestations of disease, and (3). the applicability of mouse models for testing new treatments for allergic asthma...
  27. ncbi Allergen provocation increases TH2-cytokines and FOXP3 expression in the asthmatic lung
    S Thunberg
    Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute, University Hospital, Stockholm, Sweden
    Allergy 65:311-8. 2010
    ..The objective of this study was to investigate local and systemic regulatory mechanisms in the early asthmatic response to bronchial allergen provocation...
  28. pmc Airway hyperresponsiveness in allergically inflamed mice: the role of airway closure
    Lennart K A Lundblad
    Vermont Lung Center, The University of Vermont College of Medicine, HSRF 230, 149 Beaumont Avenue, Burlington, VT 05405 0075, USA
    Am J Respir Crit Care Med 175:768-74. 2007
    ..Allergically inflamed mice exhibit airway hyperresponsiveness to inhaled methacholine, which computer simulations of lung impedance suggest is due to enhanced lung derecruitment and which we sought to verify in the present study...
  29. pmc The synergistic interactions of allergic lung inflammation and intratracheal cationic protein
    Jason H T Bates
    Vermont Lung Center, Burlington, Vermont, USA
    Am J Respir Crit Care Med 177:261-8. 2008
    ..We hypothesized that more severe AHR in mice could be achieved by imbuing them with more than one mechanism of AHR...
  30. ncbi Effects of steroid therapy on inflammatory cell subtypes in asthma
    Douglas C Cowan
    Dunedin School of Medicine, University of Otago, P O Box 913, Dunedin, New Zealand
    Thorax 65:384-90. 2010
    ..ICS use led to phenotype misclassification. Steroid responsiveness was greater in EA, but the absence of eosinophilia did not indicate the absence of a steroid response. In NEA this was best predicted by baseline exhaled nitric oxide...
  31. ncbi Body mass index and asthma in adults in families of subjects with asthma in Anqing, China
    J C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 164:1835-40. 2001
    ..21) (kg/m)(2) = 1.3 to 3.1; 95% CI(30) (vs.) (21) (kg/m)(2) = 1.2 to 4.5). Among adults in families of subjects with asthma living in rural China, both underweight and overweight are associated with an increased risk of asthma...
  32. ncbi Rapid onset of tolerance to beta-agonist bronchodilation
    Sarah Haney
    Department of Respiratory Medicine, Waikato Hospital, Hamilton, New Zealand
    Respir Med 99:566-71. 2005
    ..This is easily demonstrated if dilation is tested following methacholine challenge. It is not known how quickly tolerance develops or how long it lasts after stopping beta-agonist therapy...
  33. ncbi Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects
    John D Brannan
    Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Respirology 7:37-44. 2002
    ..The aim of the study was to investigate whether treatment using inhaled corticosteroids decreases airway responsiveness to inhaled mannitol in asthmatic subjects...
  34. ncbi Interpretation of the "positive" methacholine challenge
    David J Hewitt
    Center for Toxicology and Environmental Health, LLC, North Little Rock, Arkansas
    Am J Ind Med 51:769-81. 2008
    ..While sensitivity of the test in diagnosing clinically significant asthma is excellent, specificity of the test is poor. Since there are many conditions which have been associated with BHR, a positive test must be interpreted cautiously...
  35. ncbi Atopy may be related to exercise-induced bronchospasm in asthma
    Y I Koh
    Division of Allergy, Department of Internal Medicine, Chonnam National University Medical School and Research Institute of Medical Science, Kwangju, Korea
    Clin Exp Allergy 32:532-6. 2002
    ..However, it is not clear whether atopy is related to EIB, regardless of airway hyper-responsiveness (AHR) to methacholine, because asthmatic subjects often show AHR to exercise and methacholine simultaneously...
  36. ncbi Impact of specific sensitization on asthma and rhinitis in young Brazilian and Chilean adults
    R J Rona
    Department of Psychological Medicine, King s College London, London, UK
    Clin Exp Allergy 38:1778-86. 2008
    ..The pattern of associations and the attributable fractions (AF) of atopic conditions due to specific sensitizations vary between countries...
  37. ncbi Is there a need for special preventive medical check-ups in employees exposed to experimental animal dust?
    Klaus Schmid
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine of the University Erlangen Nuremberg, Erlangen, Germany
    Int Arch Occup Environ Health 82:319-27. 2009
    ..The objective is to report our first experiences with these medical check-ups in the context of academic research...
  38. ncbi Predictors of methacholine responsiveness in a general population
    Joel Schwartz
    Harvard School of Public Health, USA
    Chest 122:812-20. 2002
    ..This study aims to quantify the relative importance of different predictors of responsiveness such as age, sex, airway caliber, smoking and atopic status, and potential interactions deserving further investigation...
  39. ncbi Effect of formoterol with or without budesonide in repeated low-dose allergen challenge
    B Dahlen
    Division of Respiratory Medicine and Allergy, Dept of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Eur Respir J 33:747-53. 2009
    ..Signs of deteriorating asthma, provoked by low-dose allergen, are prevented by short-term use of budesonide/formoterol but not by temporary use of formoterol alone...
  40. ncbi Bronchial provocation tests: the rationale for using inhaled mannitol as a test for airway hyperresponsiveness
    Jorg D Leuppi
    Respiratory Medicine, Department of Internal Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 132:151-8. 2002
    ..b>Bronchial provocation tests (BPTs) with physical stimuli such as exercise, eucapnic voluntary hyperpnea and hypertonic saline have ..
  41. ncbi Diagnostic tests for occupational asthma
    David J Hendrick
    Am J Respir Crit Care Med 166:436-7. 2002
  42. ncbi The allergen specificity of the late asthmatic reaction
    M Hatzivlassiou
    Infection, Inflammation and Immunology Division, University of Southampton School of Medicine, Southampton General Hospital, UK
    Allergy 65:355-8. 2010
    ..The mechanism of the LAR is less well defined and we have hypothesized may be allergen dependent. The aim of this study was to investigate the allergen specificity of the LAR to allergen inhalation in asthma...
  43. ncbi Percentage fall in FVC at the provocative concentration of methacholine causing a 20% fall in FEV1 in symptomatic asthma and clinical remission during adolescence
    Young Yoo
    Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea
    Chest 129:272-7. 2006
    ..The percentage fall in FVC at the PC20 (deltaFVC) has been suggested to be a more useful index of disease severity in asthma than PC20...
  44. ncbi Bronchial hyperreactivity is correlated with increased baseline airway tone
    A Bergner
    Pneumology, Medizinische Klinik Innenstadt, Ziemssenstr 1, D 80336 Munich, Germany
    Eur J Med Res 11:77-84. 2006
    ..We therefore conclude that although not fulfilling the criteria for obstructive airway disease, increased airway tone may yet be relevant in asthma...
  45. ncbi Is occupational asthma to diisocyanates a non-IgE-mediated disease?
    Meinir G Jones
    Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    J Allergy Clin Immunol 117:663-9. 2006
    ..There has been much debate as to whether this is due to diisocyanate-induced asthma being mediated by non-IgE mechanisms or whether it is the result of using inappropriate conjugates...
  46. pmc Management of severe asthma in children
    Andrew Bush
    Imperial School of Medicine, National Heart and Lung Institute, Royal Brompton Hospital, London, UK
    Lancet 376:814-25. 2010
    ..However, despite the interest in innovative approaches, getting the basics right in children with apparently severe asthma will remain the foundation of management for the foreseeable future...
  47. pmc Behavioral inhibition is associated with airway hyperresponsiveness but not atopy in a monkey model of asthma
    John P Capitanio
    California National Primate Research Center, University of California, One Shields Ave, Davis, CA 95616, USA
    Psychosom Med 73:288-94. 2011
    ....
  48. ncbi An increase in bronchial responsiveness is associated with continuing or restarting smoking
    Susan Chinn
    Department of Public Health Sciences, King s College London, London, UK
    Am J Respir Crit Care Med 172:956-61. 2005
    ..Bronchial responsiveness (BHR) has been found to be associated with smoking, atopy, and lower lung function in cross-sectional studies, but there is little information on determinants of change in adults...
  49. ncbi Respiratory diseases caused by occupational exposure to 1,5-naphthalene-diisocyanate (NDI): Results of workplace-related challenge tests and antibody analyses
    X Baur
    Ordinariat und Zentralinstitut für Arbeitsmedizin ZfA, 2208, Hamburg, Germany
    Am J Ind Med 39:369-72. 2001
    ..1,5-naphthalene-diisocyanate (NDI) is an aromatic diisocyanate with a very low vapor pressure which is mainly used in the automotive industry...
  50. ncbi Diagnostic and therapeutic value of airway challenges in asthma
    Donald W Cockcroft
    Division of Respirology, Critical Care, and Sleep Medicine, Royal University Hospital, 103 Hospital Drive, Ellis Hall, 5th Floor, Saskatoon, Saskatchewan S7N0W8, Canada
    Curr Allergy Asthma Rep 9:247-53. 2009
    ..The indirect stimuli are the challenges of choice for evaluating exercise-induced bronchoconstriction...
  51. ncbi Allergen-induced bronchial inflammation in house dust mite-allergic patients with or without asthma
    C E Lopuhaä
    Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Exp Allergy 32:1720-7. 2002
    ..The level of allergen-specific IgE antibodies does not seem to be decisive for asthmatic symptoms. Moreover, levels of exposure to mite allergens do not seem to differ significantly between asthmatic and non-asthmatics individuals...
  52. ncbi [Bronchial provocation tests using methacholine, cycle ergometer exercise and free running in children with intermittent asthma]
    Ana C T G Souza
    Hospital do Servidor Público Estadual Francisco Morato de Oliveira, Sao Paulo, SP
    J Pediatr (Rio J) 81:65-72. 2005
    ..To compare airway responsiveness to methacholine, cycle ergometer exercise and free running in children with intermittent asthma...
  53. ncbi Comparison of Delta FVC (% decrease in FVC at the PC(20)) between cough-variant asthma and classic asthma
    Young Yoo
    Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea
    J Asthma 44:35-8. 2007
    ..7 +/- 3.4%) compared with the CA group (17.1 +/- 4.4%), whereas PC(20) was not different between the two groups. Our results suggest that CVA is associated with a lower level of maximal airway response than CA...
  54. ncbi Provoked models of asthma: what have we learnt?
    P M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, ON, Canada
    Clin Exp Allergy 39:181-92. 2009
    ..An emerging role for measurements of AHR is in the evaluation of the optimal treatment for patients with asthma...
  55. ncbi An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children
    Nicole Beydon
    Am J Respir Crit Care Med 175:1304-45. 2007
  56. ncbi Histamine type 1 receptor deficiency reduces airway inflammation in a murine asthma model
    Kenichi Miyamoto
    Second Department of Physiology, Showa University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 140:215-22. 2006
    ..The present study evaluated the role of histamine H1 receptors in airway allergic inflammation by comparing the development of bronchial asthma in histamine H1 receptor gene knockout (H1RKO) and wild-type mice...
  57. ncbi Association of airway hyperresponsiveness with reduced quality of life in patients with moderate to severe asthma
    Celeste Porsbjerg
    Respiratory and Allergy Research Unit, Department of Internal Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark
    Ann Allergy Asthma Immunol 98:44-50. 2007
    ..Asthma patients with AHR to methacholine have been shown to have a poorer quality of life compared with asthma patients without AHR, but it is not clear to what degree this is a result of more severe disease in patients with AHR...
  58. ncbi Histamine deficiency in gene-targeted mice strongly reduces antigen-induced airway hyper-responsiveness, eosinophilia and allergen-specific IgE
    Gergely T Kozma
    Department of Genetics, Cell and Immunobiology, Semmelweis University Medical School, Budapest 1445, Hungary
    Int Immunol 15:963-73. 2003
    ..According to our results we can suggest that the possible causes of the reduced asthma symptoms in the HDC-KO mice may be the imperfect mast and eosinophil cell system, and an altered immune response to OVA provocation and challenge...
  59. ncbi Airway responsiveness to hypertonic saline: dose-response slope or PD15?
    G de Meer
    Institute for Risk Assessment Sciences, Environmental and Occupational Health, Utrecht University, P Box 80176, 3508 TD Utrecht, The Netherlands
    Eur Respir J 25:153-8. 2005
    ..In conclusion, the continuous relationship between airway responsiveness and asthma symptoms is in favour of a noncensored measure of airway responsiveness, such as the dose-response slope...
  60. ncbi Endogenous IL-18 in experimentally induced asthma affects cytokine serum levels but is irrelevant for clinical symptoms
    Christina Hartwig
    Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Cytokine 42:298-305. 2008
    ..Thus, in contrast to conflicting data in the literature IL-18 did not suppress or enhance the pulmonary allergic immune response in a murine experimental model of asthma...
  61. pmc Prevention of bronchial hyperreactivity in a rat model of precapillary pulmonary hypertension
    Walid Habre
    Pediatric Anesthesia Unit, Geneva Children s Hospital, University Hospitals of Geneva, 6, rue Willy Donze, CH 1205, Geneva, Switzerland
    Respir Res 12:58. 2011
    ....
  62. pmc Safety of investigative bronchoscopy in the Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 128:328-336.e3. 2011
    ..We evaluated the safety aspects of this procedure in this cohort with specific focus on patients with severe asthma...
  63. ncbi Bronchial hyperresponsiveness in a population of north Finland with no previous diagnosis of asthma or chronic bronchitis assessed with histamine and methacholine tests
    Maria Juusela
    Department of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Int J Circumpolar Health 67:308-17. 2008
    ..The agreement between the methods was also evaluated...
  64. pmc Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines
    Jeffery M Cowden
    Immunology, Johnson and Johnson Pharmaceutical Research and Development, LLC San Diego, California, USA
    Respir Res 11:86. 2010
    ..In addition, effects on Th2 mediated lung dysfunction were also determined...
  65. ncbi Methacholine challenge--comparison of an ATS protocol to a new rapid single concentration technique
    Johannes Schulze
    Department of Pediatric Pulmonology and Allergy, Children s Hospital, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Respir Med 103:1898-903. 2009
    ..In clinical practice the APS-SC is a timesaving procedure and less prone to errors since only one dilution of methacholine is necessary compared to the SDM...
  66. ncbi Improvement in bronchial hyperresponsiveness with inhaled corticosteroids in children with asthma: importance of family history of bronchial hyperresponsiveness
    Young Yull Koh
    Department of Pediatrics and Clinical Research Institute, Seoul National University Hospital, 28 Yongon Dong, Chiongno gu, Seoul 110 744, Republic of Korea
    Am J Respir Crit Care Med 166:340-5. 2002
    ..531 +/- 1.726, p < 0.01). Our results suggest that a family history of BHR may be an important factor in the sensitivity of BHR of individuals with asthma to inhaled corticosteroids...
  67. ncbi Determinants of change in airway reactivity over 11 years in the SAPALDIA population study
    I Curjuric
    Swiss Tropical and Public Health Institute, Socinstrasse 57, PO Box, 4002 Basel, Switzerland
    Eur Respir J 37:492-500. 2011
    ..Mean bronchial reactivity increases after 50 yrs of age, possibly due to airway remodelling or ventilation-perfusion disturbances related to cumulative lifetime exposures...
  68. ncbi Altered innate immune response in farmers and smokers
    Karin Sahlander
    Lung and Allergy Research, National Institute of Environmental Medicine Karolinska Institutet, Stockholm, Sweden
    Innate Immun 16:27-38. 2010
    ..This increased proportion of Th2 cells and reduced TLR2 expression may have health-related implications and may be related to the increased prevalence of respiratory disorders observed in these groups...
  69. ncbi Distribution of bronchial nonspecific reactivity in the general population
    I Cerveri
    Istituto di Tisiologia e Mal App Resp, Universita di Pavia, Italy
    Chest 93:26-30. 1988
    ..The difference between asthmatic and these "normal" subjects was highly significant; nevertheless, a clear cut-off between the two groups does not appear to exist...
  70. ncbi Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice
    G Brusselle
    Department of Respiratory Diseases, University Hospital Ghent, Belgium
    Am J Respir Cell Mol Biol 12:254-9. 1995
    ..In conclusion, these data indicate that repeated allergen exposure in sensitized mice induces airway inflammation and bronchial hyperresponsiveness, and that IL-4 plays a predominant role in the pathogenesis of both phenomena...
  71. ncbi Bronchodilator tolerance: the impact of increasing bronchoconstriction
    J M Wraight
    Dept of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Eur Respir J 21:810-5. 2003
    ..Increasing bronchoconstriction conferred greater susceptibility to the effects of bronchodilator tolerance...
  72. ncbi Repeated high-dose inhalation allergen challenge in asthma
    Christopher Grainge
    University of Southampton School of Medicine, Infection, Inflammation and Immunology Division, Southampton General Hospital, Southampton, UK
    Clin Respir J 5:150-5. 2011
    ..However, the single high-dose allergen challenges that are commonly performed do not mimic repeated symptomatic environmental allergen exposure...
  73. ncbi Comparison of incremental and bolus dose inhaled allergen challenge in asthmatic patients
    D A Taylor
    Royal Brompton Clinical Studies Unit, Department of Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, UK
    Clin Exp Allergy 30:56-63. 2000
    ..Once defined, subsequent challenges are often administered as a constant dose based on the dose from the screening challenge. Previously, constant dose challenges have been employed but never validated...
  74. ncbi Influence of lung parenchymal destruction on the different indexes of the methacholine dose-response curve in COPD patients
    G T Verhoeven
    Department of Pulmonary and Intensive Care Medicine, University Hospital Dijkzigt, Erasmus Medical Center, Rotterdam, The Netherlands
    Chest 117:984-90. 2000
    ..Therefore, we studied the interrelationships between indexes of BHR, on the one hand, and markers of lung parenchymal destruction, on the other...
  75. ncbi Unevenness of ventilation assessed by the expired CO(2) gas volume versus V(T) curve in asthmatic patients
    N G Koulouris
    Respiratory Function Laboratory, Department of Respiratory Medicine, University of Athens Medical School, SOTIRIA Hospital for Diseases of the Chest, 152, Mesogion Ave, Athens GR 11527, Greece
    Respir Physiol Neurobiol 140:293-300. 2004
    ..The change of the above ratios was not related to the percentage decrease of FEV1.0 following methacholine administration...
  76. ncbi Disruption of L-histidine decarboxylase reduces airway eosinophilia but not hyperresponsiveness
    Akira Koarai
    Division of Respiratory and Infectious Diseases and Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Respir Crit Care Med 167:758-63. 2003
    ..Furthermore, allergen-induced airway hyperresponsiveness appeared to occur independently of airway eosinophilia in our present model...
  77. ncbi Bronchial allergen challenge using the Medicaid dosimeter
    Johannes Schulze
    Department of Allergy, Pulmonology and Cystic Fibrosis, Children s Hospital, Goethe University, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Int Arch Allergy Immunol 157:89-97. 2012
    ..Bronchial allergen provocations are well established in asthma research. We evaluated the reproducibility of single-concentration, single-step allergen challenges in volunteers with grass pollen allergy...
  78. ncbi Increased capsaicin cough sensitivity in patients with multiple chemical sensitivity
    Ewa Ternesten-Hasséus
    Asthma and Allergy Research Group, Department of Respiratory Medicine and Allergy, Sahlgrenska Academy, Goteborg University, Sweden
    J Occup Environ Med 44:1012-7. 2002
    ..We conclude that airway sensory reactivity is increased in patients with MCS, a finding which suggests that neurogenic factors may be of importance in this condition...
  79. ncbi Safety of segmental allergen challenge in human allergic asthma
    Peter Julius
    Department of Pneumology, University of Rostock, Rostock, Germany
    J Allergy Clin Immunol 121:712-7. 2008
    ..Segmental allergen challenge is widely used to study mechanisms of human allergic asthma. Despite the relatively large dissemination, limited information is available about the safety of this method...
  80. ncbi Bronchial reactivity indices are determinants of health-related quality of life in patients with stable asthma
    Carolina Cisneros
    Servicio de Neumologia, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria Hospital Princesa, Madrid, Spain
    Thorax 65:795-800. 2010
    ..However, this relationship still has not been sufficiently explored for bronchial reactivity indices...
  81. ncbi Deep breath reversal and exponential return of methacholine-induced obstruction in asthmatic and nonasthmatic subjects
    Andrew C Jackson
    Biomedical Engineering Dept, Boston Univ, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol (1985) 96:137-42. 2004
    ..19 +/- 4.95 and 7.14 +/- 3.56 cmH2O.l-1.s, respectively). The monoexponential recovery suggests a first-order process such as airway wall-parenchymal tissue interdependence or renewed constriction of airway smooth muscle...
  82. pmc Association between reduced bronchodilatory effect of deep inspiration and loss of alveolar attachments
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, Via Trabucco 180, 90146 Palermo, Italy
    Respir Res 6:55. 2005
    ..This study was designed to investigate whether the impairment in this effect is associated with loss of alveolar attachments...
  83. ncbi Respiratory allergy to the indoor ant (Monomorium pharaonis) not related to sting allergy
    Cheol Woo Kim
    Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea
    Ann Allergy Asthma Immunol 94:301-6. 2005
    ..The nonstinging house ant, Monomorium pharaonis (pharaoh ant), is a highly infesting species in indoor environments...
  84. ncbi Occupational exposure to inhalative irritants and methacholine responsiveness
    P Leuenberger
    Department of Internal Medicine, University Hospital Lausanne, Switzerland
    Scand J Work Environ Health 26:146-52. 2000
    ..Such effects may be stronger among atopic persons. The objective of the study was to examine the relationship between self-reports of occupational exposure to dusts, gases, vapors, aerosols, and fumes and methacholine responsiveness...
  85. ncbi EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity
    E Nizankowska-Mogilnicka
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Allergy 62:1111-8. 2007
    ..Indications, contraindications for the tests, the rules of drug withdrawal and equipment are reviewed. Patient supervision and interpretations of the tests are proposed...
  86. ncbi Levalbuterol hydrochloride
    D Slattery
    Division of Respiratory Diseases, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatr Pulmonol 33:151-7. 2002
    ..Further basic research and investigations in humans comparing both enantiomers at increasing doses over longer time periods are required to clarify the precise roles of R- and S-albuterol...
  87. ncbi Asthma in Italian conscripts: a four year study
    Andrea Vizzaccaro
    Navy Hospital, La Spezia, Allergy and ENT Unit, Head Neck Department, San Martino Hospital, Genoa, Italy
    Eur Ann Allergy Clin Immunol 35:125-9. 2003
    ..Italian conscripts showed underdiagnosis and undertreatment of asthma in a previous 9-year study (1990-1998)...
  88. ncbi Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
    Sally Wenzel
    University of Pittsburgh, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA, USA
    Lancet 370:1422-31. 2007
    ..Our aim was to assess the therapeutic effect of pitrakinra, an interleukin-4 variant that targets allergic Th2 inflammation by potently inhibiting the binding of interleukin 4 and interleukin 13 to interleukin-4Ralpha receptor complexes...
  89. ncbi Effects of obesity on perceptual and mechanical responses to bronchoconstriction in asthma
    Athavudh Deesomchok
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 181:125-33. 2010
    ..The influence of obesity on the perception of respiratory discomfort during acute bronchoconstriction in asthma is unknown...
  90. ncbi The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness
    N Scichilone
    Division of Clinical Immunology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 163:413-9. 2001
    ..The dissociation between bronchoprotection and bronchodilation suggests that the two effects involve different mechanisms...
  91. pmc Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study
    J Feary
    Division of Epidemiology and Public Health, University of Nottingham, UK
    Clin Exp Allergy 39:1060-8. 2009
    ....
  92. ncbi Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms
    Scott S Wagers
    Vermont Lung Center, Department of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Appl Physiol 102:221-30. 2007
    ..8% loss of visible lung area in A/J mice compared with 28% in antigen-sensitized and -challenged mice (P < 0.02). We conclude that the physiology of AHR depends on the mouse model used and the route of bronchial agonist administration...
  93. ncbi Selected contribution: airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations
    A Jensen
    Respiratory and Physiological Systems Identification Laboratory, Biomedical Engineering, Boston University, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 91:506-15; discussion 504-5. 2001
    ..These data suggest that the asthmatic smooth muscle resides in a stiffer biological state compared with the stimulated healthy smooth muscle, and inhibiting a DI in healthy subjects cannot mimic this...
  94. ncbi Precapillary pulmonary hypertension leads to reversible bronchial hyperreactivity in rats
    Britta S von Ungern-Sternberg
    Pediatric Anesthesia Unit, Geneva Children s Hospital, Geneva, Switzerland
    Exp Lung Res 36:129-39. 2010
    ..This may be consequent to the altered mechanical interdependence between the pulmonary vasculature and the respiratory tract...
  95. ncbi Airway re-narrowing following deep inspiration in asthmatic and nonasthmatic subjects
    C M Salome
    Woolcock Institute of Medical Research and Cooperative Research Centre for Asthma, University of Sydney, Australia
    Eur Respir J 22:62-8. 2003
    ....
  96. ncbi Short-term variability of exhaled nitric oxide in young male patients with mild asthma and in healthy subjects
    H Ekroos
    Division of Clinical Physiology and Nuclear Medicine, Helsinki University Hospital, Finland
    Respir Med 96:895-900. 2002
    ....
  97. ncbi Comparison of the dose response to levalbuterol with and without pretreatment with S-albuterol after methacholine-induced bronchoconstriction
    Hengameh H Raissy
    School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    Pharmacotherapy 27:1231-6. 2007
    ..To determine the effect of S-albuterol on the dose response to levalbuterol in patients with moderate bronchoconstriction induced by a methacholine challenge...
  98. ncbi Methacholine challenge: comparison of two methods
    Donald W Cockcroft
    Division of Respiratory Medicine, Department of Medicine, Royal University Hospital, University of Saskatchewan, Ellis Hall, Fifth Floor, Saskatoon, SK, S7N 0W8 Canada
    Chest 127:839-44. 2005
    ..Although subjects are exposed to twice as much aerosol at any given concentration during the tidal-breathing method compared to the dosimeter method, they were thought to give equivalent results...
  99. ncbi Interpretation of cough provoked by airway challenges
    Heikki O Koskela
    Department of Respiratory Medicine, Kuopio University Hospital, Finland
    Chest 128:3329-35. 2005
    ..To analyze the cough response to three airway challenges in order to clarify whether the recording of the provoked coughs would be beneficial in the management of asthma...
  100. pmc Cultured lung fibroblasts from ovalbumin-challenged "asthmatic" mice differ functionally from normal
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Am J Respir Cell Mol Biol 37:424-30. 2007
    ..The augmented profibrotic activity and mediator release of asthmatic fibroblasts could contribute to airway remodeling in asthma...
  101. ncbi Temporal profile of forced expiratory lung function in allergen-challenged Brown-Norway rats
    Chander S Celly
    Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Eur J Pharmacol 540:147-54. 2006
    ....

Research Grants52

  1. Assessment of Lung function in Mice
    Jason Bates; Fiscal Year: 2009
    ....
  2. MECHANICS OF ACUTE LUNG INJURY
    Jason Bates; Fiscal Year: 2009
    ..The results of our studies are expected to lead to the design of physiologically-based lung recruitment strategies that can be tailored to the individual patient with ALI. This will set the stage for future clinical trials. ..
  3. The Genetic Epidemiology of Asthma in Costa Rica
    JUAN CELEDON; Fiscal Year: 2005
    ..In addition, it will create a bank of phenotypic and genotypic information that will facilitate further hypothesis testing in a unique patient cohort. ..
  4. Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph Nodes
    John P Capitanio; Fiscal Year: 2010
    ..Relevance ..
  5. Airway Biology of Acute Asthma: Translational Studies
    David Peden; Fiscal Year: 2008
    ..abstract_text> ..
  6. The Effect of Mycoplasma on Chronic Asthma
    Richard Martin; Fiscal Year: 2008
    ..pneumoniae and asthma will be obtained through this PPG and will ultimately give new knowledge to the understanding of asthma pathophysiology and potential future novel therapies. ..
  7. Maternal Influence in the Development of Asthma
    Edward Barrett; Fiscal Year: 2008
    ..This application will provide new insight into the underlying mechanisms that contribute to the development of asthma and identify new targets for preventative therapies. ..
  8. Mechanisms of HSF1-mediated Repression of TNF-alpha
    Jeffrey Hasday; Fiscal Year: 2007
    ..The proposed studies will provide new insight into how the biochemical events that regulate host defenses is modified by the temperature increase that occurs during fever. ..
  9. Towards a better understanding of work-aggravated asthma
    Catherine Lemiere; Fiscal Year: 2009
    ..The occurrence of asthma exacerbations will be recorded. The economic impact of WAA will be assessed in terms of work disability and use of health resources and compared with OA and asthma without OA not WAA. ..
  10. Native LDL, Cholesterol and Impaired Vasodilation
    Kirkwood Pritchard; Fiscal Year: 2006
    ..Investigations in to how 4F protects vascular function will provide new understanding of the mechanisms by which LDL impairs vasodilation and HDL protects vascular function. ..
  11. Induction of Respiratory Tolerance By Mucosal CpG ODN
    Joel Kline; Fiscal Year: 2006
    ..Aim 2: To evaluate whether anti-inflammatory effects of airway mucosal exposure to CpG-ODN are mediated through regulatory T-lymphocytes. ..
  12. Airway as Target Organ in Infants with Atopic Dermatitis
    Robert Tepper; Fiscal Year: 2008
    ..Specific Aim # 2: Evaluate whether the presence of phenotypic characteristics of the asthmatic airway identifies infants and toddlers that develop clinical asthma by 5 years of age. [unreadable] [unreadable]..
  13. Vitamin D in Obstructive Lung Diseases
    Augusto Litonjua; Fiscal Year: 2008
    ..Additionally, supplementation with vitamin D can be implemented in cost-effective population-based programs to prevent the development of, and treat these disorders. [unreadable] [unreadable] [unreadable]..
  14. HDL Dysfunction and Vascular Inflammation
    Kirkwood A Pritchard; Fiscal Year: 2010
    ..Through these studies, new treatment modalities may be realized for preventing vascular dysfunction in a variety of diseases characterized by increases in oxidative stress and inflammation. ..
  15. The contribution of heat shock/stress pathways to acute lung injury
    Jeffrey D Hasday; Fiscal Year: 2010
    ..Ablating fever may eliminate its beneficial as well as its harmful effects. We expect that a better understanding of its molecular mechanisms will allow us to selectively block the harmful effects of fever/hyperthermia. ..
  16. Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage Function
    Anne Fitzpatrick; Fiscal Year: 2009
    ..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
  17. Gene by Environment Interactions in Asthma and Allergy
    Augusto Litonjua; Fiscal Year: 2009
    ..Blood for genetic material is currently being collected on the two cohorts, and endotoxin will be measured from stored, frozen house dust. ..
  18. GROWTH OF AIRWAYS AND LUNG PARENCHYMA IN NORMAL INFANTS
    Robert Tepper; Fiscal Year: 2009
    ..abstract_text> ..
  19. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  20. Longitudinal Lung Function Changes--Aging/Genetics/Risk
    Augusto Litonjua; Fiscal Year: 2008
    ..The results of this proposal will shed light on potential mechanisms that affect lung function decline in aging. ..
  21. Ozone and LPS-Induced Airway Inflammation In Humans In Vivo
    David Peden; Fiscal Year: 2008
    ..That low level ozone will enhance response to LPS. Testing these hypotheses will be used to better define the ways that O3 and LPS interact to exacerbate airway disease. [unreadable] [unreadable]..
  22. MUC4 Mucin and Airway Epithelial Regeneration in COPD
    Judith Voynow; Fiscal Year: 2006
    ..Our ultimate goal is to use information from this project to identify new biologic targets for rational therapies to induce normal airway epithelial proliferation and differentiation following injury. ..
  23. BODY TEMPERATURE AND REGULATING HOST DEFENSES
    Jeffrey Hasday; Fiscal Year: 2001
    ..abstract_text> ..
  24. ASTHMA CHRONOBIOLOGY: CENTRAL AND LUNG INTERACTIONS
    Richard Martin; Fiscal Year: 2003
    ....
  25. CD14 AND LPS-INDUCED INFLAMMATION IN CHRONIC BRONCHITIS
    David Peden; Fiscal Year: 2003
    ..Finally, the investigators will genotype cohorts of COPD patients and healthy smokers to determine if the T allele is a risk factor in development of COPD in those who smoke. ..
  26. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
    ..This will hopefully help to improve our therapeutic modalities for this enigmatic illness that affects millions of Americans every year. ..
  27. Obstruction in Asthma--Role of Airway Closure
    Andrew Jackson; Fiscal Year: 2003
    ..If we can demonstrate that asthma includes a major component of airway closure, this may very well identify a new direction for future research, which may lead to entirely new treatment approaches. ..
  28. CROSS REGULATION OF SIGNALING IN AIRWAY SMOOTH MUSCLE
    Charles Emala; Fiscal Year: 2002
    ....
  29. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Richard Martin; Fiscal Year: 2002
    ....
  30. BETA-2 ADRENERGIC RECEPTOR POLYMORPHISMS AND ASTHMA
    Augusto Litonjua; Fiscal Year: 2002
    ..End of Abstract) ..
  31. INDIVIDUAL FACTORS IN NASAL IRRITANT SENSITIVITY
    Dennis Shusterman; Fiscal Year: 2002
    ....
  32. SYMPTOM PERCEPTION IN CRITICAL ADOLESCENT ASTHMA
    Anthony Mansell; Fiscal Year: 2004
    ..The proposed research is expected to advance the understanding of perceptual abnormalities as risk factors for LTA and to help clinicians identify those adolescents at risk of a life-threatening asthma exacerbation. ..
  33. Hsp90 Mediates eNOS and Vascular Function
    Kirkwood Pritchard; Fiscal Year: 2005
    ..Findings from these studies will probably be relevant to and provide new understanding of mechanisms mediating vascular disease related to atherogenesis, hypertension and diabetes ..
  34. Helminth-Induced Immune Tolerance in Asthma
    Joel Kline; Fiscal Year: 2005
    ..Although completion of the second Aim is almost certainly beyond the scope of this two-year developmental research grant, these studies will be continued and extended through an R01 grant application. ..
  35. ENDOTOXIN AND BRONCHIAL INFLAMMATION IN ASTHMA
    David Peden; Fiscal Year: 2005
    ..We will also employ nasal challenge and in vitro studies of monocytic cells to examine the effect of GM-CSF and other candidate cytokines produced by IgE-mediated inflammation on in vivo and in vitro response to LPS ..
  36. Early Life Exposure to Microbial Products and Asthma
    Joel Kline; Fiscal Year: 2005
    ..Question 2A: What mediators promote immune tolerance induced by early life exposure to microbial products? Question 2B: What cells are responsible for immune tolerance induced by early life exposure to microbial products? ..
  37. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2008
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. [unreadable] [unreadable]..
  38. SIMIAN AIDS: SOCIAL STRESS, ENDOCRINE & IMMUNE FUNCTION
    John Capitanio; Fiscal Year: 2004
    ..abstract_text> ..
  39. Endotoxin Exposure Alters-Anti-Tetanus IgE in Infants
    Dennis Ownby; Fiscal Year: 2009
    ..The closer temporal relationship should produce a clearer understanding of role of early environmental exposures on the development of allergic disease. ..
  40. REGULATION OF MUCIN GENE EXPRESSION BY ELASTASE
    Judith Voynow; Fiscal Year: 2003
    ..The ultimate goal is to use information from this project to identify new biologic targets for therapeutic interventions to prevent mucus obstruction in chronic inflammatory airway diseases. ..
  41. Innovative Investigations and Therapies for Asthma
    Richard Martin; Fiscal Year: 2007
    ..The ability to predict who will and will not respond to corticosteroids and additive therapy will greatly improve our ability to treat asthma effectively. ..
  42. Mucin Gene Regulation by Elastase and Oxidants
    Judith Voynow; Fiscal Year: 2008
    ..b. To determine whether NE and/or NQO1-generated ROS affect HuR binding to MUC5AC. c. To determine whether HuR binding is sufficient for MUC5AC mRNA stabilization. ..
  43. Antibiotics in Infancy-Risk Factor for Childhood Asthma
    Dennis Ownby; Fiscal Year: 2002
    ..This new analysis will allow a much more rigorous examination of the possible relationship between early antibiotic use and asthma in a population of American children. ..
  44. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
  45. REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION
    Allan Brasier; Fiscal Year: 2006
    ..Expression of dominant-negative NF-KB and CBP/p300 coactivators will be used to determine their effect on coactivator recruitment. These studies will identify signaling mechanisms and protein interactions in viral-induced inflammation. ..
  46. MECHANISMS OF CUTANEOUS INJURY IN LUPUS ERYTHEMATOSUS
    Richard Sontheimer; Fiscal Year: 2001
    ....
  47. Mechanisms for Hormone-Dependent NF-kB Activation
    Allan Brasier; Fiscal Year: 2007
    ..These studies will identify new therapeutic targets that can disrupt the vicious cycle of inflammation and atherosclerosis. ..
  48. Differential Cytokine Secretion by Human Basophils
    John Schroeder; Fiscal Year: 2008
    ..Thus, these differential effects on basophil IL-4 and IL-13, mediated through TLR, may also help in delineating the mechanisms regulating cytokine production. ..
  49. HYPERPOLARIZED HELIUM-3 MRI OF THE LUNG IN ASTHMATICS
    Eduard de Lange; Fiscal Year: 2003
    ..The results of the studies proposed in this research will serve as a foundation for developing future clinical and basic research applications. ..
  50. OXIDATIVE STRESS, APOPTOSIS AND DRUG RESISTANCE
    Istvan Boldogh; Fiscal Year: 2003
    ..abstract_text> ..
  51. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..