blood gas analysis

Summary

Summary: Measurement of oxygen and carbon dioxide in the blood.

Top Publications

  1. ncbi Pulmonary gas exchange in the morbidly obese
    G S Zavorsky
    Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, Saint Louis, Missouri 63117, USA
    Obes Rev 9:326-39. 2008
  2. ncbi A meta-analysis on the utility of peripheral venous blood gas analyses in exacerbations of chronic obstructive pulmonary disease in the emergency department
    Beng Leong Lim
    Department of Emergency, Tan Tock Seng Hospital, Singapore
    Eur J Emerg Med 17:246-8. 2010
  3. pmc Determinants of blood pH in health and disease
    J A Kellum
    University of Pittsburgh Medical Center, Division of Critical Care, Pittsburgh, Pennsylvania 15213 2582, USA
    Crit Care 4:6-14. 2000
  4. ncbi Effect of continuous compressions and 30:2 cardiopulmonary resuscitation on global ventilation/perfusion values during resuscitation in a porcine model
    Shuo Wang
    Department of Emergency Medicine, Beijing Chaoyang Hospital affiliated with Capital Medical University, Beijing, China
    Crit Care Med 38:2024-30. 2010
  5. ncbi Injury and repair in the very immature lung following brief mechanical ventilation
    Nadine Brew
    Department of Anatomy and Developmental Biology, Monash University, Victoria, Australia
    Am J Physiol Lung Cell Mol Physiol 301:L917-26. 2011
  6. ncbi Agreement between paired blood gas values in samples transported either by a pneumatic system or by human courier
    John Victor Peter
    Medical ICU, Christian Medical College and Hospital, Vellore, India
    Clin Chem Lab Med 49:1303-9. 2011
  7. ncbi Hemolysis, lipaemia and icterus in specimens for arterial blood gas analysis
    Gian Luca Salvagno
    Sezione di Chimica Clinica, Dipartimento di Scienze della Vita e della Riproduzione, Universita degli Studi di Verona, Italy
    Clin Biochem 45:372-3. 2012
  8. ncbi Prediction of arterial blood gas values from venous blood gas values in patients with acute exacerbation of chronic obstructive pulmonary disease
    Ahmet Ak
    Department of Emergency Medicine, Faculty of Medicine, Selcuk University, Konya, Turkey
    Tohoku J Exp Med 210:285-90. 2006
  9. ncbi Comparison of blood gas and acid-base measurements in arterial and venous blood samples in patients with uremic acidosis and diabetic ketoacidosis in the emergency room
    Y Gokel
    Department of Emergency, Faculty of Medicine, Cukurova University, Adana, Turkey
    Am J Nephrol 20:319-23. 2000
  10. ncbi Arterial versus capillary blood gases: a meta-analysis
    Gerald S Zavorsky
    Department of Anesthesia, McGill University Health Center, Montreal, Quebec, Canada
    Respir Physiol Neurobiol 155:268-79. 2007

Research Grants

Detail Information

Publications263 found, 100 shown here

  1. ncbi Pulmonary gas exchange in the morbidly obese
    G S Zavorsky
    Department of Obstetrics, Gynecology and Women s Health, School of Medicine, Saint Louis University, Saint Mary s Health Center, Saint Louis, Missouri 63117, USA
    Obes Rev 9:326-39. 2008
    ..Morbidly obese women have better gas exchange at rest compared with morbidly obese men which is likely due to lower waist-to-hip ratios in women than from differences in weight or BMI...
  2. ncbi A meta-analysis on the utility of peripheral venous blood gas analyses in exacerbations of chronic obstructive pulmonary disease in the emergency department
    Beng Leong Lim
    Department of Emergency, Tan Tock Seng Hospital, Singapore
    Eur J Emerg Med 17:246-8. 2010
    ..Widespread clinical use is limited because of the lack of validation studies on clinical outcomes...
  3. pmc Determinants of blood pH in health and disease
    J A Kellum
    University of Pittsburgh Medical Center, Division of Critical Care, Pittsburgh, Pennsylvania 15213 2582, USA
    Crit Care 4:6-14. 2000
    ..All changes in blood pH, in health and in disease, occur through changes in these three variables. Clinical implications for these findings are also discussed...
  4. ncbi Effect of continuous compressions and 30:2 cardiopulmonary resuscitation on global ventilation/perfusion values during resuscitation in a porcine model
    Shuo Wang
    Department of Emergency Medicine, Beijing Chaoyang Hospital affiliated with Capital Medical University, Beijing, China
    Crit Care Med 38:2024-30. 2010
    ....
  5. ncbi Injury and repair in the very immature lung following brief mechanical ventilation
    Nadine Brew
    Department of Anatomy and Developmental Biology, Monash University, Victoria, Australia
    Am J Physiol Lung Cell Mol Physiol 301:L917-26. 2011
    ..We conclude that 2 h of MV induces severe injury in the very immature lung and that these lungs have the capacity to repair spontaneously in the absence of further ventilation...
  6. ncbi Agreement between paired blood gas values in samples transported either by a pneumatic system or by human courier
    John Victor Peter
    Medical ICU, Christian Medical College and Hospital, Vellore, India
    Clin Chem Lab Med 49:1303-9. 2011
    ..Rapid accurate assessment of metabolic derangements is crucial in the critically ill. We evaluated if arterial blood gas (ABG) samples transported through a pneumatic tube system (PTS) agreed with values transported by a human courier...
  7. ncbi Hemolysis, lipaemia and icterus in specimens for arterial blood gas analysis
    Gian Luca Salvagno
    Sezione di Chimica Clinica, Dipartimento di Scienze della Vita e della Riproduzione, Universita degli Studi di Verona, Italy
    Clin Biochem 45:372-3. 2012
    To assess prevalence of interference from hemolysis, lipaemia, icterus in arterial blood gas analysis (ABG).
  8. ncbi Prediction of arterial blood gas values from venous blood gas values in patients with acute exacerbation of chronic obstructive pulmonary disease
    Ahmet Ak
    Department of Emergency Medicine, Faculty of Medicine, Selcuk University, Konya, Turkey
    Tohoku J Exp Med 210:285-90. 2006
    ..004 x venous pH; arterial PCO(2) = 0.873 x venous PCO(2); and arterial HCO(3) = 0.951 x venous HCO(3). VBG analysis can reliably predict the ABG values of pH, PCO(2) and HCO(3) in patients with AECOPD...
  9. ncbi Comparison of blood gas and acid-base measurements in arterial and venous blood samples in patients with uremic acidosis and diabetic ketoacidosis in the emergency room
    Y Gokel
    Department of Emergency, Faculty of Medicine, Cukurova University, Adana, Turkey
    Am J Nephrol 20:319-23. 2000
    ..The aim of this study was to examine a plausible correlation between venous and arterial blood gas values in acidotic patients with chronic uremia or diabetic ketoacidosis (DKA)...
  10. ncbi Arterial versus capillary blood gases: a meta-analysis
    Gerald S Zavorsky
    Department of Anesthesia, McGill University Health Center, Montreal, Quebec, Canada
    Respir Physiol Neurobiol 155:268-79. 2007
    ....
  11. ncbi Cause of metabolic acidosis in prolonged surgery
    J H Waters
    Department of General Anesthesiology, Cleveland Clinic Foundation, OH 44195, USA
    Crit Care Med 27:2142-6. 1999
    ..In this study, dilutional acidosis was evaluated as a possible mechanism for the routine development of intraoperative acidosis in noncardiac, nonvascular surgery patients...
  12. ncbi A utilization management intervention to reduce unnecessary testing in the coronary care unit
    Thomas J Wang
    Massachusetts General Hospital, Wang Ambulatory Care Center 478, 15 Parkman St, Boston, MA 02114, USA
    Arch Intern Med 162:1885-90. 2002
    ..There have been no studies of interventions to reduce test utilization in the coronary care unit...
  13. ncbi High-frequency oscillatory ventilation following prone positioning prevents a further impairment in oxygenation
    Didier Demory
    Service de Reanimation Medicale, Hopital Sainte Marguerite, Universite de la Mediterranee, Marseille, France
    Crit Care Med 35:106-11. 2007
    ..The aim of this study was to show that HFOV is able to prevent the impairment in oxygenation when ARDS patients are turned back from the prone to the supine position...
  14. ncbi Effects of early administration of dexamethasone, N-acetylcysteine and aprotinin on inflammatory and oxidant-antioxidant status after lung contusion in rats
    Hasan Turut
    Department of Thoracic Surgery, Kahramanmaras Sutcu Imam University Medical School, Kahramanmaras, Turkey
    Injury 40:521-7. 2009
    ..We intended to determine the effects of dexamethasone (DXM), N-acetylcysteine (NAC) and aprotinin (APR) in terms of their ability to diminish the consequences of acute lung injury due to PC...
  15. pmc Comparison of arterial and venous pH, bicarbonate, PCO2 and PO2 in initial emergency department assessment
    G Malatesha
    Department of Internal Medicine and Dept of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India
    Emerg Med J 24:569-71. 2007
    ....
  16. ncbi Hypertonic saline improves tissue oxygenation and reduces systemic and pulmonary inflammatory response caused by hemorrhagic shock
    Valter Gurfinkel
    Department of Clinical Emergencies, Hospital das Clinicas, University of Sao Paulo, Brazil
    J Trauma 54:1137-45. 2003
    ....
  17. ncbi What factors influence arterial blood gas sampling patterns?
    Tom Andrews
    School of Nursing and Midwifery, University College Cork, Cork, Ireland
    Nurs Crit Care 13:132-7. 2008
    ..To investigate if patterns of arterial blood gas (ABG) sampling were influenced by values of fractional inspiratory oxygen (FiO2), partial pressure of carbon dioxide (PCO2), partial pressure of oxygen (PO2) and oxygen saturation (%SaO2)...
  18. ncbi AARC clinical practice guideline: blood gas analysis and hemoximetry: 2013
    Michael D Davis
    Adult Health and Nursing System, Virginia Commonwealth University, Richmond, Virginia
    Respir Care 58:1694-703. 2013
    ..of this clinical practice guideline is based on 237 clinical trials, 54 reviews, and 23 meta-analyses on blood gas analysis (BGA) and hemoximetry...
  19. ncbi Platelet larceny: spurious hypoxaemia due to extreme thrombocytosis
    A Mehta
    Dept of Pulmonary, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur Respir J 31:469-72. 2008
    ..The present case report demonstrates spurious hypoxaemia due to extreme thrombocytosis and shows that, beside significant leukocytosis, even markedly elevated platelet counts can cause larceny of arterial blood oxygen...
  20. ncbi Non-invasive mechanical ventilation in status asthmaticus
    M M Fernandez
    Intensive Care Department, Corporació Sanitària Parc Taulí s n, 08208 Sabadell, Spain
    Intensive Care Med 27:486-92. 2001
    ..To evaluate our clinical experience with the use of non-invasive mechanical ventilation (NIMV) in patients with an acute asthmatic attack...
  21. ncbi Potential preanalytical errors in whole-blood analysis: effect of syringe sample volume on blood gas, electrolyte and lactate values
    Pirjo Hedberg
    Laboratory, Oulu University Hospital, Department of Clinical Chemistry, University of Oulu, Finland
    Scand J Clin Lab Invest 69:585-91. 2009
    ..Collection of a blood specimen, as well as its handling and transport, belong to the key factors to affect the accuracy and good quality of clinical laboratory analysis...
  22. ncbi Spurious hypoxaemia in a patient with leukaemia and extreme leucocytosis
    S M Khoo
    Department of Medicine, National University Hospital, Lower Kent Ridge Road, Singapore 119074
    Singapore Med J 44:208-10. 2003
    ..Serial arterial blood gas analysis also demonstrated a slower initial rate of decay of PaO2 as the leucocyte count decreased with treatment.
  23. ncbi IFCC guideline for sampling, measuring and reporting ionized magnesium in plasma
    Mohammed C Ben Rayana
    Department of Chemistry, University of Newcastle upon Tyne, UK
    Clin Chem Lab Med 46:21-6. 2008
    ....
  24. ncbi Influence of spurious hemolysis on blood gas analysis
    Giuseppe Lippi
    Laboratory of Clinical Chemistry and Haematology, Department of Pathology and Laboratory Medicine, Academic Hospital of Parma, 43126 Parma, Italy
    Clin Chem Lab Med 51:1651-4. 2013
    Although the prevalence of hemolyzed samples referred for blood gas analysis is as high as 4%, no studies have assessed the bias introduced by spurious erythrocyte breakdown, nor it is known which parameters are mostly influenced and to ..
  25. ncbi Blood gas and patient safety: considerations based on experience developed in accordance with the Risk Management perspective
    Marco Rambaldi
    U O Anestesia e Rianimazione, Azienda Sanitaria di Modena, Modena, Italy
    Clin Chem Lab Med 45:774-80. 2007
    ..In practice this is equivalent to a specific assurance stipulation with zero cost...
  26. ncbi Spurious hypoxemia
    Abhijit V Lele
    Neurosciences Critical Care Division, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 33:1854-6. 2005
    ..To discuss the pathophysiology and clinical implications of spurious hypoxemia in the setting of hyperleukocytosis...
  27. ncbi Effects of different resuscitation fluids on acute lung injury in a rat model of uncontrolled hemorrhagic shock and infection
    Ju Gao
    Department of Anesthesiology, The People s Hospital of Qingyuan, Guangdong, China
    J Trauma 67:1213-9. 2009
    ..To investigate the effects of different resuscitation fluids on acute lung injury in a rat model of uncontrolled hemorrhagic shock (HS) followed by mimicked infection...
  28. ncbi Comparison of ventral coccygeal arterial and jugular venous blood samples for pH, pCO2, HCO3, Be(ecf) and ctCO2 values in calves with pulmonary diseases
    Vehbi Gunes
    Department of Internal Medicine, Faculty of Veterinary Medicine, University of Kafkas, Kars 36100, Turkey
    Res Vet Sci 81:148-51. 2006
    ..8%, 77.1%, 70.3%. In conclusion, venous blood gas values can predict arterial blood gas values of pH, pCO2 and HCO3ecf, Be(ecf) and ctCO2- for healthy calves but only pH values in calves with acute respiratory problems (r2 value>80%)...
  29. ncbi Congenital diaphragmatic hernia: a simplified postnatal predictor of outcome
    Cynthia M Schultz
    Division of Neonatology, Wilford Hall USAF Medical Center, 2200 Bergquist Dr, Lackland AFB, TX 78236, USA
    J Pediatr Surg 42:510-6. 2007
    ..The purpose of this study was to develop and validate a simplified clinical method for predicting survival outcomes in infants born with CDH...
  30. pmc The acute toxicity and hematological characterization of the effects of tentacle-only extract from the jellyfish Cyanea capillata
    Liang Xiao
    Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China
    Mar Drugs 9:526-34. 2011
    ..capillata and indicate that it may also have neurotoxicity, liver toxicity and muscular toxicity in addition to hemolytic and cardiovascular toxicities, but no kidney or pancreatic toxicity...
  31. ncbi A novel technique for monitoring of fast variations in brain oxygen tension using an uncoated fluorescence quenching probe (Foxy AL-300)
    Klaus Ulrich Klein
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Medical University Vienna, Vienna, Austria
    J Neurosurg Anesthesiol 23:341-6. 2011
    ..The present study reports the first use of the technology for dual measurements of arterial (paO(2)) and brain tissue oxygen tension (ptiO(2)) during hypoxic challenge in a pig model...
  32. pmc The effects of different syringe volume, needle size and sample volume on blood gas analysis in syringes washed with heparin
    Tuncay Kume
    Dokuz Eylul University Medical School, Department of Medical Biochemistry, Izmir, Turkey
    Biochem Med (Zagreb) 22:189-201. 2012
    We evaluated the effect of different syringe volume, needle size and sample volume on blood gas analysis in syringes washed with heparin.
  33. ncbi [Hemodynamic monitoring in one-lung ventilation]
    S Haas
    Klinik und Poliklinik für Anästhesiologie, Zentrum für Anästhesiologie und Intensivmedizin, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246, Hamburg, Deutschland
    Anaesthesist 58:1085-96. 2009
    ..This article will review the current literature on hemodynamic monitoring in one-lung ventilation in order to derive recommendations for the application of hemodynamic monitoring in this specific peri-operative situation...
  34. ncbi Analytical performance evaluation of four cartridge-type blood gas analyzers
    Anne Sophie De Koninck
    Department Bioanalysis, Laboratory of Medical Biochemistry and Clinical Analysis, Ghent University, Faculty of Pharmaceutical Sciences, Ghent, Belgium
    Clin Chem Lab Med 50:1083-91. 2012
    ....
  35. ncbi Women at altitude: ventilatory acclimatization at 4,300 m
    S R Muza
    United States Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    J Appl Physiol (1985) 91:1791-9. 2001
    ....
  36. ncbi The accuracy of the central venous blood gas for acid-base monitoring
    Allan J Walkey
    Boston University Pulmonary Center, Boston, MA 02118, USA
    J Intensive Care Med 25:104-10. 2010
    ..Routine use of central venous blood gases (VBGs) may reduce complications from prolonged arterial cannulation. We investigated the reliability of the VBG as a substitute for arterial blood gas (ABG) in multiple care settings...
  37. ncbi Effects of air bubbles and tube transportation on blood oxygen tension in arterial blood gas analysis
    Jin Ying Lu
    Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
    J Formos Med Assoc 102:246-9. 2003
    ..The aim of this study was to clarify the effect of manual and pneumatic tube methods of sample transportation and different amounts of air bubbles on arterial blood gas analysis.
  38. ncbi Physiologic effects of nasal oxygen or medical air administered prior to and during carfentanil-xylazine anesthesia in North American elk (Cervus canadensis manitobensis)
    Jessica M Paterson
    Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada
    J Zoo Wildl Med 40:39-50. 2009
    ..Oxygen administration reduced hypoxemia and improved anesthesia quality, but caused prolonged periods of apnea, and moderate to severe hypercarbia and respiratory acidosis...
  39. ncbi Does compression-only cardiopulmonary resuscitation generate adequate passive ventilation during cardiac arrest?
    Charles D Deakin
    South Central Ambulance Service NHS Trust Hampshire Division, Highcroft, Romsey Road, Winchester SO22 5DH, UK
    Resuscitation 75:53-9. 2007
    ..We measured passive ventilation during optimal chest compression to determine whether compression-only CPR provides adequate gas exchange during cardiac arrest...
  40. ncbi [Visceral syndrome differentiation in traditional Chinese medicine and the changes of nutrition status or blood gas analysis in patients with chronic obstructive pulmonary disease]
    Bing Mao
    Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
    Zhong Xi Yi Jie He Xue Bao 5:506-9. 2007
    To investigate the relationship between visceral syndrome differentiation in traditional Chinese medicine (TCM) and the changes of nutrition status or blood gas analysis in patients with chronic obstructive pulmonary disease (COPD).
  41. ncbi Butorphanol, azaperone, and medetomidine anesthesia in free-ranging white-tailed deer (Odocoileus virginianus) using radiotransmitter darts
    Jessica Siegal-Willott
    Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida 32610, USA
    J Wildl Dis 45:468-80. 2009
    ..No known mortalities occurred as a result of the study. This drug combination provided safe, reliable, short-term anesthesia of free-ranging white-tailed deer. Further evaluation for use in field procedures in other cervids is warranted...
  42. ncbi Diagnosis and treatment of simple acid-base disorders
    Phil Ayers
    Mississippi Baptist Medical Center, Department of Pharmacy, Jackson, MS 39202 2002, USA
    Nutr Clin Pract 23:122-7. 2008
    ..This review will discuss the diagnosis and treatment of common metabolic and respiratory disorders encountered in nutrition support practice...
  43. ncbi Effects of syringe type and storage temperature on results of blood gas analysis in arterial blood of horses
    Valerie Picandet
    Department of Clinical Sciences, Faculty of Veterinary Medicine, Universite de Montreal, Saint Hyacinthe, QC, Canada
    J Vet Intern Med 21:476-81. 2007
    Results of arterial blood gas analysis can be biased by pre-analytical factors, such as time to analysis, syringe type, and temperature during storage...
  44. ncbi A review of alpha2 adrenoreceptor agonists and the development of hypoxemia in domestic and wild ruminants
    Matt R Read
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    J Zoo Wildl Med 34:134-8. 2003
    ..Effective and safe immobilization of these animals requires knowledge of the mechanisms behind these changes and the methods that offset their effects, including the use of supplemental oxygen...
  45. ncbi Arterial blood gas analysis in the initial evaluation of the nonintubated adult blunt trauma patient
    Erik Barquist
    Department of Surgery, University of Miami, Miami, Florida 33101, USA
    J Trauma 52:601-2. 2002
  46. ncbi The implications of arterial Po2 oscillations for conventional arterial blood gas analysis
    Birgit Pfeiffer
    Department of Anesthesia, Section of Critical Care, School of Veterinary Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Anesth Analg 102:1758-64. 2006
    ..When atelectasis is recruited with each breath, interpretation of changes in shunt fraction, based on conventional ABG analysis, should account for potentially large respiratory variations in arterial Po2...
  47. ncbi The invention and development of blood gas analysis apparatus
    John W Severinghaus
    Department of Anesthesiology, University of California Medical School, San Francisco, California 94143 0542, USA
    Anesthesiology 97:253-6. 2002
    ..Technician Bradley and Dr. Severinghaus combined these, making the first blood gas analysis system in 1957 and 1958, and shortly thereafter, they added a pH electrode...
  48. ncbi Gastric capnometry with air-automated tonometry predicts outcome in critically ill patients
    Bruno Levy
    Réanimation Médicale, Hopital Central, Nancy, France
    Crit Care Med 31:474-80. 2003
    ..Contrary to tonometer gastric intramucosal pH, there is currently no validated threshold prognostic value for Pco2 gap (tonometer gastric mucosal Pco2 minus arterial Pco2) in the critically ill patient...
  49. pmc Treatment of hypoxemia during xylazine-tiletamine-zolazepam immobilization of wapiti
    M R Read
    Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4
    Can Vet J 42:861-4. 2001
    ..Pulse oximetry and arterial blood gas analysis were used to assess the degree of hypoxemia prior to nasal insufflation of oxygen and to demonstrate any ..
  50. ncbi Maintenance of end-expiratory recruitment with increased respiratory rate after saline-lavage lung injury
    Rebecca S Syring
    Department of Clinical Studies, Section of Critical Care, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Appl Physiol 102:331-9. 2007
    ..001). Prevention of end-expiratory derecruitment without increased end-expiratory pressure suggests that another mechanism, distinct from intrinsic PEEP, plays a role in the dynamic behavior of atelectasis...
  51. ncbi Accuracy of noninvasive multiwave pulse oximetry compared with carboxyhemoglobin from blood gas analysis in unselected emergency department patients
    Dominik Roth
    Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria
    Ann Emerg Med 58:74-9. 2011
    ..We assess bias and precision of COHb oximetry compared with the criterion standard blood gas analysis.
  52. ncbi Effect of acute metabolic acid/base shifts on the human airway calibre
    F Brijker
    Department of Pulmonology, Velp Hospital, TA Arnhem, The Netherlands
    Respir Physiol 124:151-8. 2001
    ..Changes in R(aw) and sG(aw) were contrary to those in alkalosis, but did not reach statistical significance. Acute metabolic acid-base shifts mildly influence the airway calibre in healthy human subjects...
  53. pmc Dynamic arterial blood gas analysis in conscious, unrestrained C57BL/6J mice during exposure to intermittent hypoxia
    Euhan J Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, Dept of Medicine, Univ of Pittsburgh, NW628 MUH, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    J Appl Physiol (1985) 107:290-4. 2009
    ..46 +/- 0.2. We conclude that the magnitude of oxyhemoglobin desaturation that is induced in our murine model of IH is consistent with the degree of hypoxic stress that occurs in moderate to severe clinical OSA...
  54. ncbi Comparison of combined oximetry and cutaneous capnography using a digital sensor with arterial blood gas analysis
    Prashant N Chhajed
    Clinic for Pulmonary Medicine, University Hospital, Basel, Switzerland
    Scand J Clin Lab Invest 70:60-4. 2010
    ..Cutaneous carbon dioxide tension (PcCO(2)) is a promising non-invasive surrogate measure of arterial partial pressure of carbon dioxide (PaCO(2))...
  55. ncbi Effect of the umbilical cord blood acid-base status and gas values on the yield of mononuclear cells and CD34⁺ cells
    Satoko Ebina
    Department of Disability and Health, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan
    J Obstet Gynaecol Res 38:997-1003. 2012
    ..The relationship of these values with the yield of mononuclear cells and CD34⁺ cells detected in venous CB was analyzed...
  56. ncbi Benefits of introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit
    Christopher R H White
    The University of Western Australia, Perth, Australia
    Aust N Z J Obstet Gynaecol 50:318-28. 2010
    ..However, there's debate whether umbilical cord blood gas analysis (UC-BGA) should be conducted on some or all deliveries.
  57. ncbi Effect of passive pneumoperitoneum on oesophageal pressure, cardiovascular parameters and blood gas analysis in horses
    P A Canola
    Sao Paulo State University, School of Agrarian Sciences and Veterinary Medicine, Veterinary Surgery Graduate Program, Sao Paulo, Brazil
    Equine Vet J 43:446-50. 2011
    ..Standing surgical procedures are being employed to an ever-greater extent in horses. Pneumoperitoneum during abdominal surgery might adversely affect the work of breathing...
  58. ncbi Carbon dioxide-induced retinopathy in the neonatal rat
    J M Holmes
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Curr Eye Res 17:608-16. 1998
    ..We investigated the effect of hypercarbia on the retinal vasculature of the neonatal rat to determine whether hypercarbia alone could induce preretinal neovascularization analogous to ROP...
  59. ncbi Mismatch of arterial and central venous blood gas analysis during haemorrhage
    Oliver M Theusinger
    Institute of Anaesthesiology, University Hospital Zurich, Zurich
    Eur J Anaesthesiol 27:890-6. 2010
    Arterial base excess and lactate levels are key parameters in the assessment of critically ill patients. The use of venous blood gas analysis may be of clinical interest when no arterial blood is available initially.
  60. ncbi Effects of prone position on alveolar recruitment and oxygenation in acute lung injury
    C Guerin
    Service de Réanimation Médicale et Assistance Respiratoire, Hopital de la Croix Rousse, Lyon, France
    Intensive Care Med 25:1222-30. 1999
    ..To investigate the effects of prone position (PP) on alveolar recruitment and oxygenation in acute respiratory failure...
  61. ncbi Validity of venous blood gas analysis for diagnosis of acid-base imbalance in children admitted to pediatric intensive care unit
    Nemat Bilan
    Department of Pediatrics, Tabriz Children s Hospital, Tabriz University of Medical Sciences, Tabriz, IR Iran
    World J Pediatr 4:114-7. 2008
    ..This study aimed to evaluate the validity of VBG and its clinical agreement with ABG in the 10 most common diseases in pediatric intensive care unit (PICU), and to answer how far it can replace the ABG test...
  62. ncbi Diagnostic value of arterial blood gas measurement in suspected pulmonary embolism
    M A Rodger
    Department of Medicine, University of Ottawa, Ontario, Canada
    Am J Respir Crit Care Med 162:2105-8. 2000
    ..We conclude that ABG data alone or in combination with other clinical data are not useful in the assessment of suspected PE...
  63. pmc The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia
    K A Fagan
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver 80262, USA
    J Clin Invest 103:291-9. 1999
    ..We conclude that eNOS-derived NO is an important modulator of the pulmonary vascular response to chronic hypoxia and that more than 50% of eNOS expression is required to maintain normal pulmonary vascular tone...
  64. ncbi Evaluation of the newborn's blood gas status. National Academy of Clinical Biochemistry
    R T Brouillette
    The Department of Pediatrics, McGill University Montreal Children s Hospital, Canada
    Clin Chem 43:215-21. 1997
    ..Blood gases obtained in the immediate perinatal period can help assess perinatal asphyxia, but particular attention must be paid to the sampling site, the time of life, and the possible and proven diagnoses...
  65. ncbi Comparison of optimal positive end-expiratory pressure and recruitment maneuvers during lung-protective mechanical ventilation in patients with acute lung injury/acute respiratory distress syndrome
    Michel Badet
    Service de Réanimation Médicale et Assistance Respiratoire, Hopital de la Croix Rousse, 69004 Lyon, France
    Respir Care 54:847-54. 2009
    ..Recruitment maneuvers are closely linked to the selection of positive end-expiratory pressure (PEEP), which is also a subject of debate...
  66. pmc High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial [ISRCTN24242669]
    Casper W Bollen
    Intensive Care, University Medical Centre Utrecht, The Netherlands
    Crit Care 9:R430-9. 2005
    ....
  67. pmc Impact of emergency intubation on central venous oxygen saturation in critically ill patients: a multicenter observational study
    Glenn Hernandez
    Departamento de Medicina Intensiva, Pontificia Universidad Catolica de Chile, Marcoleta 367, Santiago, Chile
    Crit Care 13:R63. 2009
    ..Therefore, we conducted a study to determine the impact of emergency intubation on ScvO2...
  68. ncbi Physiologic impact of closed-system endotracheal suctioning in spontaneously breathing patients receiving mechanical ventilation
    Christopher W Seymour
    Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Respir Care 54:367-74. 2009
    ..Endotracheal suctioning is required but can have adverse effects, and could affect cardiorespiratory variables that are used to predict whether the patient is ready for extubation...
  69. ncbi Application of C1-esterase inhibitor during reperfusion of ischemic myocardium: dose-related beneficial versus detrimental effects
    G Horstick
    2nd Medical Clinic, Institute for Neurosurgical Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Circulation 104:3125-31. 2001
    ..However, overly high doses (>/=100 IU/kg) of C1-INH will provoke detrimental side effects, probably via its procoagulatory action...
  70. ncbi Impact of positive end-expiratory pressure on the definition of acute respiratory distress syndrome
    Elisa Estenssoro
    Servicio de Terapia Intensiva, Hospital Interzonal General de Agudos General San Martín, 1900, La Plata, Argentina
    Intensive Care Med 29:1936-42. 2003
    ..We examined whether PEEP during the first hours of ARDS can induce such a change in oxygenation that could mask fulfillment of the AECC criteria of a PaO(2)/FIO(2) </= 200 essential for ARDS diagnosis...
  71. ncbi Effect of twin-to-twin delivery interval on umbilical cord blood gas in the second twins
    Tak Yeung Leung
    Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    BJOG 109:63-7. 2002
    ..To examine the effect of twin-to-twin delivery interval on the umbilical cord blood gas status of the second twin following vaginal delivery...
  72. pmc Venous pH can safely replace arterial pH in the initial evaluation of patients in the emergency department
    A M Kelly
    Department of Emergency Medicine, Western Hospital, Private Bag, Footscray 3011, Melbourne, Australia
    Emerg Med J 18:340-2. 2001
    ....
  73. ncbi Dose end-tidal carbon dioxide measurement correlate with arterial carbon dioxide in extremely low birth weight infants in the first week of life?
    Soraisham Amuchou Singh
    Department of Pediatrics, University of Calgary, Alberta, Canada
    Indian Pediatr 43:20-5. 2006
    ..To study the correlation and agreement between end-tidal carbon dioxide (EtCO2) and arterial carbon dioxide (PaCO(2)) in ventilated extremely low birth weight (ELBW) infants in the first week of life...
  74. ncbi Combination of venoarterial PCO2 difference with arteriovenous O2 content difference to detect anaerobic metabolism in patients
    Armand Mekontso-Dessap
    Service de Reanimation Medicale, Centre Hospitalier Universitaire de Bicetre, Assistance Publique, Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Intensive Care Med 28:272-7. 2002
    ..We tested the value of the DeltaPCO2/C(a-v)O2 ratio in detecting the presence of global anaerobic metabolism as defined by an increase in arterial lactate level above 2 mmol/l (Lac+)...
  75. pmc Arterial blood gas and pulse oximetry in initial management of patients with community-acquired pneumonia
    K P Levin
    Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Gen Intern Med 16:590-8. 2001
    ..Increasing the assessment of arterial oxygenation among patients with CAP is likely to increase the detection of arterial hypoxemia, particularly among outpatients...
  76. ncbi Calculation of physiological acid-base parameters in multicompartment systems with application to human blood
    E Wrenn Wooten
    Department of Radiology, Baylor University Medical Center, Dallas, Texas 75246, USA
    J Appl Physiol 95:2333-44. 2003
    ..The multicompartment model brings the strong ion difference theory to the same quantitative level as the base excess method...
  77. ncbi A combined ear sensor for pulse oximetry and carbon dioxide tension monitoring: accuracy in critically ill children
    Andres Tschupp
    SenTec Inc, Therwil, Switzerland
    Anesth Analg 96:82-4, table of contents. 2003
    ..It provides noninvasive and continuous monitoring of arterial oxygen saturation, arterial carbon dioxide tension, and pulse rate. The sensor proved to be clinically accurate in the tested range...
  78. ncbi Prolonged invasive ventilation following acute ventilatory failure in COPD: weaning results, survival, and the role of noninvasive ventilation
    Timothy G Quinnell
    Respiratory Support and Sleep Centre, Papworth Hospital, Papworth Everard, Cambridge, UK CB3 8RE
    Chest 129:133-9. 2006
    ..We analyzed our results for patients with COPD to identify factors associated with weaning outcome and survival...
  79. ncbi Changes in FiO2 affect PaO2 with minor alterations in cerebral concentration of oxygenated hemoglobin during liquid ventilation in healthy piglets
    Wolfram Burkhardt
    Clinic of Neonatology, Charité Mitte, Schumannstrasse 20, 10098, Berlin, Germany
    Intensive Care Med 30:315-20. 2004
    ..To measure the impact of changes in the fraction of inspired oxygen (FiO2) on systemic and cerebral oxygen supply in gas and liquid ventilated healthy animals...
  80. ncbi Hypocapnia and other ventilation-related risk factors for cerebral palsy in low birth weight infants
    M P Collins
    Department of Epidemiology, Michigan State University, East Lansing, Michigan 48823, USA
    Pediatr Res 50:712-9. 2001
    ..Avoidance of arterial PCO(2) levels <35 mm Hg and arterial PO(2) levels >60 mm Hg in mechanically ventilated very low birth weight infants would seem prudent...
  81. pmc Quality improvement report: Linking guideline to regular feedback to increase appropriate requests for clinical tests: blood gas analysis in intensive care
    P Merlani
    Division of Surgical Intensive Care, Department of Anaesthesiology, Pharmacology, and Surgical Intensive Care, Geneva University Hospital, 1211 Geneva 4, Switzerland
    BMJ 323:620-4. 2001
    PROBLEM: Need to decrease the number of requests for arterial blood gas analysis and increase their appropriateness to reduce the amount of blood drawn from patients, the time wasted by nurses, and the related cost...
  82. ncbi Effects of syringe material, sample storage time, and temperature on blood gases and oxygen saturation in arterialized human blood samples
    Thomas P Knowles
    Cardiothoracic Anesthesia Department, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Respir Care 51:732-6. 2006
    ....
  83. pmc Correlation of simultaneously obtained capillary, venous, and arterial blood gases of patients in a paediatric intensive care unit
    D Yildizdas
    Cukurova University, Faculty of Medicine, Department of Pediatrics, Pediatric Intensive Care Unit, 01330, Adana, Turkey
    Arch Dis Child 89:176-80. 2004
    ..To investigate the correlation of pH, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), base excess (BE), and bicarbonate (HCO3) between arterial (ABG), venous (VBG), and capillary (CBG) blood gases...
  84. ncbi Lack of agreement between thermodilution and carbon dioxide-rebreathing cardiac output
    L B Nilsson
    Department of Anaesthesiology, Gentofte Hospital, University of Copenhagen, Denmark
    Acta Anaesthesiol Scand 45:680-5. 2001
    ..The repeatability of the partial CO2-rebreathing technique holds promise that a sufficient accuracy may be obtained by suitable modifications of the monitor's algorithms...
  85. ncbi Controlled contrast transcranial Doppler and arterial blood gas analysis to quantify shunt through patent foramen ovale
    Gerald Devuyst
    Department of Neurology, CHUV, Avenue du Bugnon 46, 1011 Lausanne, Switzerland
    Stroke 35:859-63. 2004
    ....
  86. ncbi Mechanical ventilation in healthy mice induces reversible pulmonary and systemic cytokine elevation with preserved alveolar integrity: an in vivo model using clinical relevant ventilation settings
    Michiel Vaneker
    Department of Anesthesiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Anesthesiology 107:419-26. 2007
    ..To study mechanotransduction in vivo, the authors used an animal MV model with clinically relevant ventilator settings, avoiding alveolar damage...
  87. pmc Value of arterial blood gas analysis in patients with acute dyspnea: an observational study
    Emanuel Burri
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, Basel, Switzerland
    Crit Care 15:R145. 2011
    The diagnostic and prognostic value of arterial blood gas analysis (ABGA) parameters in unselected patients presenting with acute dyspnea to the Emergency Department (ED) is largely unknown.
  88. ncbi Validation of venous pCO2 to screen for arterial hypercarbia in patients with chronic obstructive airways disease
    Anne Maree Kelly
    Joseph Epstein Centre for Emergency Medicine Research, Footscray, Victoria, Australia
    J Emerg Med 28:377-9. 2005
    ..In conclusion, pvCO2 can be used as a screening test for arterial hypercarbia, and if employed, can potentially reduce the requirement for ABG sampling...
  89. ncbi Meaning of arterio-venous PCO2 difference in circulatory shock
    B Lamia
    Unit of Medical Intensive Care, Bicetre University Hospital, University Paris XI, Paris, France
    Minerva Anestesiol 72:597-604. 2006
    ..e. cardiac output) to remove the total CO2 produced by the peripheral tissues. In this regard, the knowledge of DeltaPCO2 should help the clinicians for the decision of giving therapy aimed at increasing cardiac output...
  90. ncbi Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock
    Marjut Varpula
    Helsinki University Hospital, POB 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 32:1336-43. 2006
    ..The aim of our study was to assess the correlation and agreement of ScvO2 and SvO2 and compare ScvO2-SvO2 difference to lactate, oxygen-derived and hemodynamic parameters in early septic shock in ICU after initial resuscitation...
  91. ncbi Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury
    Lewis J Kaplan
    Yale University School of Medicine, Department of Surgery, Section of Trauma, Critical Care, and Emergency General Surgery, USA
    Crit Care Med 32:1120-4. 2004
    ..This study determines whether acid-base data obtained in the emergency department correlate with outcome from major vascular injury...
  92. ncbi Reproducibility of an animal model simulating complex combat-related injury in a multiple-institution format
    S David Cho
    Division of Trauma and Critical Care, Oregon Health and Science University, Portland, Oregon 97239, USA
    Shock 31:87-96. 2009
    ..A consistent severe injury profile was achieved, after which experimental interventions can be applied. This is the first report of a reproducible multicenter trauma and resuscitation-related animal model...
  93. ncbi Beneficial effects of hypertonic saline/dextran on early survival in porcine endotoxin shock
    A Somell
    Department of Anaesthesiology and Intensive Care, Karolinska University Hospital and Institute, Huddinge, Sweden
    Acta Anaesthesiol Scand 49:1124-34. 2005
    ..However, this is less studied. We have therefore further evaluated the effect of additional treatment with HSD in a porcine endotoxin shock model...
  94. ncbi Endotoxic shock model with fluid resuscitation in Macaca mulatta
    Guo Qing Yin
    The Second Hospital of Nanjing, affiliated with Medical College, Southeast University, 1 1 Zhongfu Road, Nanjing, Jiangsu, 210003, People s Republic of China
    Lab Anim 39:269-79. 2005
    ..Pathological changes of myocardium were identified in all of the LPS groups. The studies suggest that macaques are suitable models for studying endotoxic shock and potential fluid therapies...
  95. ncbi Changes in acid-base balance following bolus infusion of 20% albumin solution in humans
    Dirk Bruegger
    Clinic of Anesthesiology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Intensive Care Med 31:1123-7. 2005
    ..To evaluate changes in acid-base balance following bolus infusions of a 20% albumin solution...
  96. ncbi Central venous-arterial carbon dioxide difference as an indicator of cardiac index
    Joseph Cuschieri
    Department of Surgery, Henry Ford Health Systems, Detroit, MI, USA
    Intensive Care Med 31:818-22. 2005
    ..A central venous pCO(2), which is easier to obtain, may provide similar information. The purpose of this study was to examine the correlation between the central venous-arterial pCO(2) difference and CI...
  97. ncbi The cerebral microcirculation is protected during experimental hemorrhagic shock
    Zhi Wan
    Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA
    Crit Care Med 38:928-32. 2010
    ..We propose to relate changes in the macrocirculation to the buccal and cerebral microcirculations during hemorrhage and after fluid resuscitation...
  98. pmc Extravascular lung water assessed by transpulmonary single thermodilution and postmortem gravimetry in sheep
    Mikhail Y Kirov
    Department of Anesthesiology, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    Crit Care 8:R451-8. 2004
    ..The aim of the present study was to compare two methods for quantification of EVLW: transpulmonary single thermodilution (EVLWST) and postmortem gravimetric (EVLWG)...
  99. ncbi Cardiovascular and pulmonary effects of hetastarch plus hypertonic saline solutions during experimental endotoxemia in anesthetized horses
    Lucas G Pantaleon
    Marion duPont Scott Equine Medical Center, Virginia Maryland Regional College of Veterinary Medicine, Leesburg, VA, USA
    J Vet Intern Med 20:1422-8. 2006
    ..The objective of this study was to determine the cardiopulmonary effects of small-volume resuscitation using hypertonic saline solution (HSS) plus Hetastarch (HES) during experimental endotoxemia in anesthetized horses...
  100. ncbi Waist-to-hip ratio is associated with pulmonary gas exchange in the morbidly obese
    Gerald S Zavorsky
    Department of Anesthesia, McGill University Health Center, Montreal General Hospital, 1650 Cedar Ave, Room D10 144, Montreal, QC, Canada H3G 1A4
    Chest 131:362-7. 2007
    ..Morbidly obese individuals (ie, body mass index [BMI], > or = 40 kg/m2) may have a pulmonary gas exchange impairment due to the large fat mass surrounding their abdomen...
  101. ncbi Erythrocyte 2,3-diphosphoglycerate depletion associated with hypophosphatemia detected by routine arterial blood gas analysis
    V H Larsen
    Department of Anesthesiology, Herlev Hospital, University of Copenhagen, Denmark
    Scand J Clin Lab Invest Suppl 224:83-7. 1996
    ..where an extremely low erythrocyte 2,3-diphosphoglycerate concentration (2,3-DPG) was discovered by routine blood gas analysis supplemented by computer calculation of derived quantities...

Research Grants62

  1. Microvascular injury after Subarachnoid Hemorrhage
    Fatima A Sehba; Fiscal Year: 2010
    ....
  2. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  3. Time-Dependent Changes in Respiratory Control After Perinatal Hyperoxia
    RYAN BAVIS; Fiscal Year: 2008
    ..Therefore, it is critical to understand how environmental conditions in early life influence development of protective chemoreflexes. [unreadable] [unreadable] [unreadable]..
  4. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  5. DOPAMINE AND PLASTICITY IN RESPIRATORY CONTROL
    Rebecca Johnson; Fiscal Year: 2002
    ..End of Abstract) ..
  6. Female Sex Hormones and Spinal Injury
    David Fuller; Fiscal Year: 2006
    ..abstract_text> ..
  7. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  8. Gut Ischemia/Reperfusion Injury: Modulation by Nutrients
    Rosemary Kozar; Fiscal Year: 2006
    ..The sponsors are an integral part of this arrangement and are especially suited to ensure success of the proposed project...
  9. Zinc Neurotoxicity in Traumatic Brain Injury
    Donald Prough; Fiscal Year: 2006
    ..Methodologies: identical to specific aim 1 plus monitoring for signs of neurologic zinc deficiency. ..
  10. Aerosolized PGE1 in Neonatal Pulmonary Hypertension
    BEENA SOOD; Fiscal Year: 2005
    ..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
  11. Regional Hypoxic Pulmonary Vasoconstriction
    MICHAEL HLASTALA; Fiscal Year: 2006
    ..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. [unreadable] [unreadable]..
  12. Development of Cerebral Autoregulation in VLBW Infants
    Jeffrey Kaiser; Fiscal Year: 2006
    ..Kaiser will take advantage of the strong mentoring, protected research time and outstanding academic resources of the University of Arkansas for Medical Sciences to reach his goal of becoming an independent investigator. ..
  13. Nicotine Replacement Treatment for Pregnant Smokers
    Cheryl Oncken; Fiscal Year: 2006
    ..The odds of cigarette abstinence will be increased primarily in subjects who smoke at least 15 cigarettes per day...
  14. O2 Delivery and Functional Sympatholysis in Human Muscle
    BRADLEY WILKINS; Fiscal Year: 2006
    ..The results of these experiments will provide important new information about the interactions between neural and local factors controlling blood flow to exercising human skeletal muscle. ..
  15. Effects of aging on sleep architecture
    Naresh Punjabi; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  16. Arterial cell signaling in vasodilatory shock.
    Melissa Evans; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  17. Artery Wall Hypoxia and Intimal Hyperplasia
    Steven Santilli; Fiscal Year: 2009
    ..abstract_text> ..
  18. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2008
    ..abstract_text> ..
  19. Longtitudinal Changes in Sleep Structure: Implications for Health Outcomes
    Naresh Punjabi; Fiscal Year: 2010
    ....
  20. THE SLEEP HEART HEALTH STUDY
    Naresh Punjabi; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..
  21. Morphine versus Methadone as First Line Strong Opioid for Cancer Pain
    Eduardo Bruera; Fiscal Year: 2009
    ..Relevance to Public Health: In this study, we will test if methadone is better than morphine in cancer pain control, quality of life, and is more cost-effective. ..
  22. Physician Training Program in Neonatal Biology
    John Widness; Fiscal Year: 2007
    ..With NIH support beyond that which the investigators currently enjoy, the investigators will be able to significantly enhance the research training experiences they offer their postdoctoral physician trainees in neonatal medicine. ..
  23. Microbubbles: a novel treatment for hemorrhagic shock
    CLAS LUNDGREN; Fiscal Year: 2007
    ..The project is expected to bring the DDFPe treatment to a state of scientific underpinning and applicability in the animal model which lays a solid foundation for pursuing FDA approval for human use. ..
  24. Parenteral Hydration in Advanced Cancer Patients: A Randomized Controlled Trial
    Eduardo Bruera; Fiscal Year: 2009
    ..In this study, we will test if giving fluid through the vein will improve the symptoms, delay confusion and prolong life in patients who are no longer to drink at the end of life. ..
  25. Neuroimaging of Genetically-Defined Incipient CJD
    Isak Prohovnik; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. TZD Treatment of Cocaine Toxicity
    Guy Weinberg; Fiscal Year: 2005
    ..We will also establish an isolated heart model to study the potential for clinical application of TZDs to treat acute cocaine cardiac toxicity. ..
  27. Fetal Programming of Coronary Artery Disease
    JEFFREY SEGAR; Fiscal Year: 2005
    ..Only when the causes and mechanisms of hypertension and cardiovascular disease are understood in the context of a developmental process will it be possible to develop strategies for primary prevention. ..
  28. ADENOSINE AND THE NEURONAL RESPONSE TO HYPOXIA/ISCHEMIA
    John Fowler; Fiscal Year: 2001
    ..And, examine adenosine receptor function in the post-ischemic period after the anoxic depolarization. ..
  29. DEVELOPMENTAL PLASTICITY IN VENTILATORY CONTROL
    Gordon Mitchell; Fiscal Year: 2001
    ..Further understanding of mechanism(s) that underlie developmental plasticity with its associated functional impairments may provide the rationale for therapeutic intervention, thereby enhancing functional recovery. ..
  30. MUSCLE CAPILLARY GEOMETRY, FLOW, AND OXYGEN TRANSFER
    David Poole; Fiscal Year: 2001
    ....
  31. SPINAL CORD INJURY, METHYLPREDNISOLONE & P GLYCOPROTEIN
    CHRISTOPHER BERNARDS; Fiscal Year: 2002
    ..4. To determine whether increased spinal cord bioavailability of methylprednisolone decreases secondary damage following spinal cord injury. ..
  32. Deposition of 0.5 to 2 Micron Aerosol in the Human Lung
    G Prisk; Fiscal Year: 2003
    ..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
  33. THE CPA: SOMATIC AND AUTONOMIC SYSTEMS
    W Panneton; Fiscal Year: 2004
    ..Understanding the brainstem mechanisms governing he vascular constriction after either of these somatic stimuli may provide a neurological explanation for this. Such knowledge may lead to an understanding of essential hypertension. ..
  34. Diaphragm Fatigue:Mechanisms of Treatment by Dopamine
    Janet Pierce; Fiscal Year: 2004
    ..Data obtained from this research will advance our understanding of biological systems, and thus provide data to support clinical trials using dopamine to prevent and treat DF. ..
  35. SYMPATHETIC EXCITATORY RESPONSE AT BIRTH
    JEFFREY SEGAR; Fiscal Year: 2001
    ....
  36. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..
  37. Ventilator-Induced Lung Injury in Children
    Sabrina Heidemann; Fiscal Year: 2004
    ..The results of this study may serve as the basis for a multicenter clinical trial. ..
  38. Heart Rate Variability in Mecp2 Deficient Mice
    JOHN BISSONNETTE; Fiscal Year: 2005
    ..These studies will contribute to the understanding of depressed parasympathetic activity in Rett syndrome. ..
  39. PLASTICITY IN RESPIRATORY MOTOR CONTROL
    Gordon Mitchell; Fiscal Year: 2004
    ..A multidisciplinary approach will be used to test key elements of the model. ..
  40. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2009
    ..3) Define and quantify the relationship between alterations in the heterogeneity of pulmonary blood flow and lung water content using functional magnetic resonance imaging (fMRI) and X-ray techniques. ..
  41. Development of a Novel Gas Embolotherapy Technique
    JOSEPH BULL; Fiscal Year: 2005
    ..The proposed research is an essential first step in developing this potentially revolutionary technique. ..
  42. Methylphenidate for Fatigue in Advanced Cancer Patients
    Eduardo Bruera; Fiscal Year: 2009
    ....
  43. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  44. CSF AND THE CENTRAL CHEMICAL CONTROL OF BREATHING
    Eugene Nattie; Fiscal Year: 2008
    ..abstract_text> ..
  45. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
  46. Effects of Chronic Hypercapnia on Chemosensitive Neurons
    LYNN HARTZLER; Fiscal Year: 2006
    ..The findings will be of relevance to pathological conditions that involve chronic hypercapnia, such as heart failure or chronic obstructive pulmonary disease. ..
  47. EARLY IDENTIFICATION AND TREATMENT OF SLEEP APNEA
    Naresh Punjabi; Fiscal Year: 2003
    ..Punjabi the opportunity to reach his full potential as a clinical investigator. ..
  48. Role of IGF-1 In Diastolic Dysfunction of Aging
    Leanne Groban; Fiscal Year: 2003
    ..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
  49. PERINATAL HYPEROXIA AND ADULT ARTERIAL CHEMORECEPTION
    Gerald Bisgard; Fiscal Year: 2004
    ....
  50. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..The long-term goal of our experiments is to provide the knowledge required to develop clinical strategies to oppose the deleterious effects of MV on respiratory muscles. ..
  51. Fetal Cardiac Hypertrophy: Vascular/Metabolic Adaptation
    JEFFREY SEGAR; Fiscal Year: 2004
    ..The end result is hoped to be that the infant with a more 'normal' heart and circulatory physiology will have improved survival with less morbidity. ..
  52. MOLECULAR PHARMACOLOGY OF GLUTAMATE RECEPTORS
    Keith Williams; Fiscal Year: 2008
    ..abstract_text> ..
  53. High Dose Erythropoetin Neuroprotection Trial for Neonatal Cardiac Surgery
    Dean Andropoulos; Fiscal Year: 2008
    ..This study will show if babies that are given erythropoetin have fewer delays in development than babies that do not receive the drug. [unreadable] [unreadable] [unreadable]..
  54. Exercise, Antioxidants, and I-R Injury
    Scott Powers; Fiscal Year: 2006
    ..abstract_text> ..
  55. Mechanical Ventilation and Diaphragmatic Oxidant Injury
    Scott Powers; Fiscal Year: 2008
    ..abstract_text> ..
  56. VASCULAR ALPHA2 ADRENOCEPTORS IN NITRIC OXIDE SYNTHASE I
    Nancy Kanagy; Fiscal Year: 2002
    ..End of Abstract) ..
  57. Control of breathing during physiological conditions
    Hubert V Forster; Fiscal Year: 2010
    ....
  58. Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.
    Nancy L Kanagy; Fiscal Year: 2010
    ....
  59. Regulation of Fetal Cardiac Growth After Correction of Increased Hemodynamic Load
    Sonnet Jonker; Fiscal Year: 2008
    ..We are trying to learn how the hearts of fetuses recover from such conditions. This will help us know when fetal therapies will do the most good. [unreadable] [unreadable] [unreadable]..