respiratory function tests

Summary

Summary: Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.

Top Publications

  1. ncbi Interpretative strategies for lung function tests
    R Pellegrino
    Internal Medicine, University of Genoa, V le Benedetto XV, 6, Genova I 16132, Italy
    Eur Respir J 26:948-68. 2005
  2. ncbi Standardisation of the single-breath determination of carbon monoxide uptake in the lung
    N MacIntyre
    Duke University Medical Center, Durham, NC, USA
    Eur Respir J 26:720-35. 2005
  3. ncbi General considerations for lung function testing
    M R Miller
    University Hospital Birmingham NHS Trust, UK
    Eur Respir J 26:153-61. 2005
  4. ncbi Characteristics of physical activities in daily life in chronic obstructive pulmonary disease
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 171:972-7. 2005
  5. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
  6. ncbi The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Chest 127:1952-9. 2005
  7. ncbi New reference values for forced spirometry in white adults in Brazil
    Carlos Alberto de Castro Pereira
    Service of Pulmonology Department, Hospital do Servidor Publico Estadual, HSPE, Sao Paulo, SP, Brazil
    J Bras Pneumol 33:397-406. 2007
  8. ncbi Outcomes for COPD pharmacological trials: from lung function to biomarkers
    M Cazzola
    Unit of Respiratory Diseases, Dept of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur Respir J 31:416-69. 2008
  9. ncbi Relationship between serum 25-hydroxyvitamin d and pulmonary function in the third national health and nutrition examination survey
    Peter N Black
    Department of Medicine, University of Auckland, Private Bag 92019 Auckland, New Zealand
    Chest 128:3792-8. 2005
  10. pmc Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study
    Christine R Jenkins
    Woolcock Institute of Medical Research, Sydney, Australia
    Respir Res 10:59. 2009

Detail Information

Publications291 found, 100 shown here

  1. ncbi Interpretative strategies for lung function tests
    R Pellegrino
    Internal Medicine, University of Genoa, V le Benedetto XV, 6, Genova I 16132, Italy
    Eur Respir J 26:948-68. 2005
  2. ncbi Standardisation of the single-breath determination of carbon monoxide uptake in the lung
    N MacIntyre
    Duke University Medical Center, Durham, NC, USA
    Eur Respir J 26:720-35. 2005
  3. ncbi General considerations for lung function testing
    M R Miller
    University Hospital Birmingham NHS Trust, UK
    Eur Respir J 26:153-61. 2005
  4. ncbi Characteristics of physical activities in daily life in chronic obstructive pulmonary disease
    Fabio Pitta
    Respiratory Rehabilitation and Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 171:972-7. 2005
    ..28 < r < 0.64, p < 0.05). Patients with chronic obstructive pulmonary disease are markedly inactive in daily life. Functional exercise capacity is the strongest correlate of physical activities in daily life...
  5. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
    ..These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease...
  6. ncbi The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Chest 127:1952-9. 2005
    ..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
  7. ncbi New reference values for forced spirometry in white adults in Brazil
    Carlos Alberto de Castro Pereira
    Service of Pulmonology Department, Hospital do Servidor Publico Estadual, HSPE, Sao Paulo, SP, Brazil
    J Bras Pneumol 33:397-406. 2007
    ..To describe spirometric reference equations for healthy Brazilian adults who have never smoked and to compare the predicted values with those derived in 1992...
  8. ncbi Outcomes for COPD pharmacological trials: from lung function to biomarkers
    M Cazzola
    Unit of Respiratory Diseases, Dept of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur Respir J 31:416-69. 2008
    ..Based on their review of the published literature, the following document has been prepared with individual sections that address specific outcomes and markers, and a final section that summarises their recommendations...
  9. ncbi Relationship between serum 25-hydroxyvitamin d and pulmonary function in the third national health and nutrition examination survey
    Peter N Black
    Department of Medicine, University of Auckland, Private Bag 92019 Auckland, New Zealand
    Chest 128:3792-8. 2005
    ..Low concentrations of vitamin D have been associated with a number of diseases, including osteoporosis, hypertension, and type I diabetes. It is possible that serum concentrations of vitamin D might also influence pulmonary function...
  10. pmc Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study
    Christine R Jenkins
    Woolcock Institute of Medical Research, Sydney, Australia
    Respir Res 10:59. 2009
    ..However, there are only limited data about the influence of GOLD severity staging on the effectiveness of SFC, particularly in patients with milder disease...
  11. ncbi A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
    Malcolm R Sears
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ont, Canada
    N Engl J Med 349:1414-22. 2003
    ..The outcome of childhood asthma in adults has been described in high-risk cohorts, but few population-based studies have reported the risk factors for persistence and relapse...
  12. ncbi Body composition and mortality in chronic obstructive pulmonary disease
    Annemie M W J Schols
    Department of Respiratory Medicine, University of Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 82:53-9. 2005
    ..Survival studies have consistently shown significantly greater mortality rates in underweight and normal-weight patients with chronic obstructive pulmonary disease (COPD) than in overweight and obese COPD patients...
  13. ncbi Identification of chronic obstructive pulmonary disease in lung cancer screening computed tomographic scans
    Onno M Mets
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, Postbus 85500, 3508GA Utrecht, The Netherlands
    JAMA 306:1775-81. 2011
    ..Smoking is a major risk factor for both cancer and chronic obstructive pulmonary disease (COPD). Computed tomography (CT)-based lung cancer screening may provide an opportunity to detect additional individuals with COPD at an early stage...
  14. ncbi Interpreting thresholds for a clinically significant change in health status in asthma and COPD
    P W Jones
    St George s Hospital Medical School, London, UK
    Eur Respir J 19:398-404. 2002
    ..Finally, an attempt is made to translate these thresholds into scenarios that illustrate what a clinically significant change with treatment may mean to an individual patient...
  15. ncbi Hospitalizations and mortality in the Lung Health Study
    Nicholas R Anthonisen
    University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Respir Crit Care Med 166:333-9. 2002
    ..When all participants were considered and smoking status considered as a time-dependent covariate, smoking cessation was associated with significant reductions in fatal or nonfatal cardiovascular disease and coronary artery disease...
  16. pmc A genome-wide association study of pulmonary function measures in the Framingham Heart Study
    Jemma B Wilk
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    PLoS Genet 5:e1000429. 2009
    ..Though it is unclear what gene or regulatory effect explains the association, the region warrants further investigation...
  17. ncbi CT scan findings of emphysema predict mortality in COPD
    Akane Haruna
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Chest 138:635-40. 2010
    ..However, few studies have assessed the relationship between CT scan assessment and COPD mortality from mild to severe stages of the disease. In this study, we analyzed this relationship in patients with various stages of COPD...
  18. pmc Health-related quality of life is related to COPD disease severity
    Elisabeth Stahl
    Department of Respiratory Medicine and Allergology, University Hospital, SE 221 85 Lund, Sweden
    Health Qual Life Outcomes 3:56. 2005
    ..The aim of this study was to evaluate the association between health-related quality of life (HRQL) and disease severity using lung function measures...
  19. ncbi The effects of body mass index on lung volumes
    Richard L Jones
    Pulmonary Division, University of Alberta, Edmonton, AB, Canada T6G 2B7
    Chest 130:827-33. 2006
    ..It is well known that obesity causes decreases in lung volumes, but there has never been a large study showing the correlation between body mass index (BMI) and the various lung volumes...
  20. ncbi Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study
    H J Schünemann
    Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, NY 14214 3000, USA
    Chest 118:656-64. 2000
    ..The purpose of this study was to investigate the predictive value of pulmonary function by gender after 29 years of follow-up...
  21. ncbi Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease
    Masaharu Nishimura
    First Department of Medicine, Hokkaido University School of Medicine, and Center for Respiratory Diseases, Hokkaido Social Insurance Hospital, N 15 W 7, Kita ku, Sapporo 060 8638, Japan
    Am J Respir Crit Care Med 185:44-52. 2012
    ..Although the rate of annual decline in FEV1 is one of the most important outcome measures in chronic obstructive pulmonary disease (COPD), little is known about intersubject variability based on clinical phenotypes...
  22. ncbi Gender and COPD in patients attending a pulmonary clinic
    Juan P de Torres
    Respiratory Research Unit, Hospital Nuestra Sra de Candelaria, Tenerife, Spain
    Chest 128:2012-6. 2005
    ..To compare gender differences in the clinical expression of COPD patients attending a pulmonary clinic...
  23. ncbi Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease
    D E O'Donnell
    Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Canada
    Eur Respir J 24:86-94. 2004
    ..Bronchodilator-induced lung deflation reduced mechanical restriction, increased ventilatory capacity and decreased respiratory discomfort, thereby increasing exercise endurance...
  24. pmc Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    N Engl J Med 358:140-51. 2008
    ..The drug sirolimus suppresses mTOR signaling...
  25. ncbi Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease
    Karine Marquis
    Centre de Recherche, Hopital Laval, Institut Universtaire de Cardiologie et de Pneumologie de L Université Laval, Quebec, Canada
    Am J Respir Crit Care Med 166:809-13. 2002
    ..These findings suggest that the assessment of body composition may be useful in the clinical evaluation of these patients...
  26. ncbi Prediction equations for normal and low lung function from the Health Survey for England
    E Falaschetti
    Dept of Epidemiology and Public Health, Royal Free and University College Medical School, London, UK
    Eur Respir J 23:456-63. 2004
    ..It is, therefore, suggested that these newly developed prediction equations be used for the White English population in both epidemiological studies and clinical practice...
  27. ncbi Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria
    Marc Estenne
    Erasme University Hospital, Brussels, Belgium
    J Heart Lung Transplant 21:297-310. 2002
  28. ncbi An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children
    Nicole Beydon
    Am J Respir Crit Care Med 175:1304-45. 2007
  29. ncbi Early identification of small airways disease on lung cancer screening CT: comparison of current air trapping measures
    Onno M Mets
    Department of Radiology, University Medical Centre Utrecht, Heidelberglaan 100, HP E01 132, Postbus 85500, 3508 GA, Utrecht, The Netherlands
    Lung 190:629-33. 2012
    ..We studied which of the currently suggested measures is most suitable for detecting functionally relevant air trapping on low-dose computed tomography (CT) in a population of subjects with early-stage disease...
  30. pmc Sex differences in severe pulmonary emphysema
    Fernando J Martinez
    University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, Michigan 48109 0360, USA
    Am J Respir Crit Care Med 176:243-52. 2007
    ..Limited data on sex differences in advanced COPD are available...
  31. pmc Outcome measures in chronic obstructive pulmonary disease (COPD): strengths and limitations
    Thomas Glaab
    Pulmonary Department, University Hospital, Johannes Gutenberg University, Mainz, Germany
    Respir Res 11:79. 2010
    ....
  32. ncbi A comparison of the level of dyspnea vs disease severity in indicating the health-related quality of life of patients with COPD
    T Hajiro
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Chest 116:1632-7. 1999
    ..To compare categorizations of the level of dyspnea with the staging of disease severity as defined by the FEV(1) in representing how the health-related quality of life (HRQOL) is distributed in patients with COPD...
  33. ncbi Exercise pathophysiology in patients with primary pulmonary hypertension
    X G Sun
    Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA
    Circulation 104:429-35. 2001
    ..CONCLUSIONS: Patients with PPH can safely undergo noninvasive cycle ergometer CPET to their maximal tolerance. The CPET abnormalities were consistent and characteristic and correlated well with NYHA class...
  34. pmc Genetic ancestry in lung-function predictions
    Rajesh Kumar
    Division of Allergy and Immunology, Children s Memorial Hospital, 2300 Children s Plaza, Box 60, Chicago IL 60614, USA
    N Engl J Med 363:321-30. 2010
    ....
  35. ncbi A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis
    Ganesh Raghu
    Division of Pulmonary Medicine, University of Washington, Seattle 98195, USA
    N Engl J Med 350:125-33. 2004
    ..Idiopathic pulmonary fibrosis is a progressive, fatal disease with no known efficacious therapy...
  36. ncbi Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, California, USA
    Drugs 68:1975-2000. 2008
    ..Budesonide/formoterol dry powder inhaler (DPI) has demonstrated efficacy and tolerability in patients with COPD...
  37. ncbi Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death
    Anselm K Gitt
    Herzzentrum Ludwigshafen, Department of Cardiology, Ludwigshafen, Germany
    Circulation 106:3079-84. 2002
    ..Thus, we compared these parameters with peak VO2 in identifying patients with CHF at increased risk for death within 6 months after evaluation...
  38. ncbi Cyclophosphamide versus placebo in scleroderma lung disease
    Donald P Tashkin
    University of California at Los Angeles, Los Angeles, USA
    N Engl J Med 354:2655-66. 2006
    ....
  39. ncbi Clinical significance of radiologic characterizations in COPD
    MeiLan K Han
    University of Michigan Health System, Ann Arbor, Michigan 48109 5360, USA
    COPD 6:459-67. 2009
    ..Future research should clarify whether CT parameters complement BODE score in influencing survival...
  40. ncbi Evaluation of respiratory impedance in asthma and COPD by an impulse oscillation system
    Shintarou Kanda
    The First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Intern Med 49:23-30. 2010
    ..The purpose of this study was to clarify the differences in physiological properties of the airways between asthma and COPD using an impulse oscillation system (IOS)...
  41. ncbi Measurement of breathlessness in advanced disease: a systematic review
    C Bausewein
    Department of Palliative Care, Policy and Rehabilitation, King s College London, Weston Education Centre, Denmark Hill, Cutcombe Road, London SE5 9RJ, UK
    Respir Med 101:399-410. 2007
    ..The aim of this systematic review was to identify all measures available via standard search techniques and review their usefulness for patients with advanced disease...
  42. ncbi Serum CC-chemokine ligand 18 concentration predicts outcome in idiopathic pulmonary fibrosis
    Antje Prasse
    Department of Pneumology, University Freiburg, Germany
    Am J Respir Crit Care Med 179:717-23. 2009
    ..Conclusive data for any serum biomarker are lacking. We have recently documented that serum CCL18 concentrations correlate with the course of pulmonary function data in patients with pulmonary fibrosis of various causes...
  43. pmc Increased sputum and bronchial biopsy IL-13 expression in severe asthma
    Shironjit K Saha
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:685-91. 2008
    ..The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 in severe asthma needs to be further defined...
  44. ncbi Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends
    Panagiota I Latsi
    Interstitial Lung Disease Unit, Emmanuel Kaye Building, Manresa Road, Chelsea, London SW6 LR6, UK
    Am J Respir Crit Care Med 168:531-7. 2003
    ..Their histologic distinction provides no additional prognostic information when pulmonary function trends are clear cut or when functional impairment is severe...
  45. ncbi Clinical analysis of chronic obstructive pulmonary disease phenotypes classified using high-resolution computed tomography
    Keisaku Fujimoto
    1st Department of Internal Medicine, Shinsu University School of Medicine, Matsumoto, Japan
    Respirology 11:731-40. 2006
    ....
  46. ncbi Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1/vital capacity ratio: a longitudinal population study from childhood to adulthood
    Finn Rasmussen
    Firestone Institute for Respiratory Health, St Joseph s Hospital and McMaster University, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 165:1480-8. 2002
    ..These data suggest that airway remodeling in asthma, as manifested by impaired lung function, begins in childhood and continues into adult life...
  47. doi Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society
    B Bradley
    Royal Infirmary Edinburgh, Little France Crescent, Edinburgh EH16 4SA, UK
    Thorax 63:v1-58. 2008
  48. ncbi The forced oscillation technique in clinical practice: methodology, recommendations and future developments
    E Oostveen
    Dept of Pulmonary Medicine, University Hospital Antwerp, Belgium
    Eur Respir J 22:1026-41. 2003
    ..Novel applications of forced oscillation technique in the clinical setting include the monitoring of respiratory mechanics during mechanical ventilation and sleep...
  49. ncbi Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease
    Yuji Higashimoto
    Department of Respiratory Medicine and Allergology, Kinki University School of Medicine, 377 2 Ohnohigashi, Osakasayama, Osaka, 589 8511 Japan
    Respir Med 103:1231-8. 2009
    ..We examined correlations between serum biomarkers and the decline of lung function in COPD patients...
  50. ncbi Forced spirometry reference values for Norwegian adults: the Bronchial Obstruction in Nord-Trøndelag Study
    A Langhammer
    , The Norwegian University of Science and Technology (NTNU, Verdal
    Eur Respir J 18:770-9. 2001
    ..Healthcare providers should be encouraged to reconsider their choice of prediction equations of spirometry in order to improve management of obstructive lung diseases...
  51. ncbi The progression of chronic obstructive pulmonary disease is heterogeneous: the experience of the BODE cohort
    Ciro Casanova
    Pulmonary Department, Hospital Universitario La Candelaria, Tenerife, Spain
    Am J Respir Crit Care Med 184:1015-21. 2011
    ..Chronic obstructive pulmonary disease (COPD) is thought to result in rapid and progressive loss of lung function usually expressed as mean values for whole cohorts...
  52. ncbi Threshold effect of urinary glycosaminoglycans and the walk test as indicators of disease progression in a survey of subjects with Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)
    Stuart J Swiedler
    BioMarin Pharmaceutical Inc, Novato, California, USA
    Am J Med Genet A 134:144-50. 2005
    ..Pending the collection of longitudinal data, these results suggest that urinary GAG levels predict clinical morbidity, and longer-term survival is associated with urinary GAG levels below a threshold of 100 mug/mg creatinine...
  53. ncbi Abdominal obesity and respiratory function in men and women in the EPIC-Norfolk Study, United Kingdom
    D Canoy
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    Am J Epidemiol 159:1140-9. 2004
    ..In the general adult population, abdominal fat deposition may play a role in the impairment of respiratory function among the abdominally obese...
  54. ncbi MDCT assessment of airway wall thickness in COPD patients using a new method: correlations with pulmonary function tests
    Tobias Achenbach
    Department of Diagnostic and Interventional Radiology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101, Mainz, Germany
    Eur Radiol 18:2731-8. 2008
    ..In COPD patients, the wall thickness measured as a mean for a given patient correlated with the values of FEV1 and FEV1% predicted. Correlation with FEV1 was higher when only small airways were considered...
  55. pmc Validation of the clinical COPD Questionnaire (CCQ) in primary care
    Bjorn Stallberg
    Department of Public Health and Caring Sciences, Section of Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala, Sweden
    Health Qual Life Outcomes 7:26. 2009
    ..The newly developed, short Clinical COPD Questionnaire, CCQ, was therefore validated against the St George's Respiratory Questionnaire (SGRQ)...
  56. ncbi Idiopathic pulmonary fibrosis: physiologic tests, quantitative CT indexes, and CT visual scores as predictors of mortality
    Alan C Best
    Department of Radiology, University of Colorado Denver, 4200 E 9th Ave, Denver, CO 80262, USA
    Radiology 246:935-40. 2008
    ....
  57. ncbi Oxidative status in the lungs associated with tobacco smoke exposure
    Sibel Doruk
    Department of Pulmonary Medicine, Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey
    Clin Chem Lab Med 49:2007-12. 2011
    ..We aimed to investigate oxidative stress in the lungs associated with TS and to evaluate the effect of this stress with pulmonary function tests (PFTs)...
  58. ncbi Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation
    Ilaria Orlandi
    Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, Viale Morgagni 85, Florence 50134, Italy
    Radiology 234:604-10. 2005
    ....
  59. ncbi Invasive and noninvasive lung function measurements in rodents
    Heinz Gerd Hoymann
    Fraunhofer Institute of Toxicology and Experimental Medicine ITEM, Nikolai Fuchs Str 1, Hannover, Germany
    J Pharmacol Toxicol Methods 55:16-26. 2007
    ....
  60. pmc Respiratory and skeletal muscle strength in chronic obstructive pulmonary disease: impact on exercise capacity and lower extremity function
    Jonathan Singer
    Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California, San Francisco, California 94143, USA
    J Cardiopulm Rehabil Prev 31:111-9. 2011
    ..We sought to quantify the impact of respiratory muscle and lower extremity strength on exercise capacity and lower extremity function (LEF) in patients with chronic obstructive pulmonary disease (COPD)...
  61. ncbi Predictive equations for lung function based on a large occupational population in North China
    Yonghui Wu
    Department of Occupational Health, School of Public Health, Harbin Medical University, PR China
    J Occup Health 51:471-7. 2009
    ..The currently used predictive equations of lung function in North China were derived from early study and have not been updated for nearly two decades...
  62. ncbi Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening
    Peter D Sly
    Division of Clinical Sciences, Telethon Institute for Child Health Research, PO Box 855, W Perth, WA 6872, Australia
    Am J Respir Crit Care Med 180:146-52. 2009
    ..The promise of newborn screening (NBS) for cystic fibrosis (CF) has not been fully realized, and the extent of improvement in respiratory outcomes is unclear. We hypothesized that significant lung disease was present at diagnosis...
  63. ncbi Lung clearance index in the assessment of airways disease
    Alex Horsley
    Department of Respiratory Medicine, Edinburgh Royal Infirmary, 51 Little France Crescent, Edinburgh EH4 2XU, United Kingdom
    Respir Med 103:793-9. 2009
    ..Thorax, 2008;63(2):96-7]. This review will consider how LCI is derived, how it differs from conventional lung function testing, and its applications and limitations...
  64. ncbi Cutting edge technologies in respiratory research: lung function testing
    Gregory G King
    Woolcock Institute of Medical Research, The Northern Clinical School, Sydney Medical School, University of Sydney, New South Wales, Australia
    Respirology 16:883-90. 2011
    ..Optical coherence tomography, optical reflection, electrical impedance and vibration response imaging have arisen by development of novel devices. The recent use of these techniques is reviewed...
  65. ncbi Pulmonary tuberculosis, impaired lung function, disability and quality of life in a high-burden setting
    G P Maguire
    International Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia
    Int J Tuberc Lung Dis 13:1500-6. 2009
    ..Tuberculosis treatment clinic in Papua, Indonesia...
  66. ncbi Serial measurements of lung function in a cohort of young children with bronchopulmonary dysplasia
    Khoulood F Fakhoury
    Pulmonary Section, Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, TX 77030, USA
    Pediatrics 125:e1441-7. 2010
    ..We aimed to prospectively and longitudinally measure lung function in a cohort of children with bronchopulmonary dysplasia (BPD) during their first 3 years of life...
  67. ncbi The influence of gastroesophageal reflux in the lung: a case-control study
    Kornelija Mise
    Clinical Department for Respiratory Diseases, Split University Hospital, Split, Croatia
    Respirology 15:837-42. 2010
    ..We also wished to determine whether an acidic environment in the lung influences pulmonary function and DL(CO), and whether microaspiration of gastric contents directly influences non-specific inflammation in the lung...
  68. ncbi Risk factors for chronic obstructive pulmonary disease in a European cohort of young adults
    Roberto de Marco
    Department of Public Health and Community Medicine, University of Verona, Istituti Biologici II, Verona, Italy
    Am J Respir Crit Care Med 183:891-7. 2011
    ..Few studies have investigated the factors associated with the early inception of chronic obstructive pulmonary disease (COPD)...
  69. pmc Effect of acute hypoxia on respiratory muscle fatigue in healthy humans
    Samuel Verges
    HP2 laboratory INSERM ERI17, Joseph Fourier University, Grenoble University Hospital, Grenoble, France
    Respir Res 11:109. 2010
    ..Hence, we assessed the effect of different blood oxygenation level on isolated hyperpnoea-induced inspiratory and expiratory muscle fatigue...
  70. ncbi Chronic obstructive pulmonary disease diagnosis and management in older adults
    Nalaka S Gooneratne
    Division of Geriatric Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 58:1153-62. 2010
    ..Clinicians caring for older adults with an acute COPD exacerbation should also guard against prognostic pessimism. Although COPD is associated with significant disability, there is a growing range of treatment options to assist patients...
  71. pmc Sputum eosinophilia can predict responsiveness to inhaled corticosteroid treatment in patients with overlap syndrome of COPD and asthma
    Yoshiaki Kitaguchi
    First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Int J Chron Obstruct Pulmon Dis 7:283-9. 2012
    ..It was hypothesized that patients with overlap syndrome may have different clinical characteristics such as sputum eosinophilia, and better responsiveness to treatment with inhaled corticosteroid (ICS)...
  72. ncbi Body mass index may modify asthma prevalence among low-birth-weight children
    Frank Leigh Lu
    Division of Pediatric Pulmonology and Critical Care Medicine, Department of Pediatrics, National Taiwan University Hospital and National Taiwan University Medical College, Taipei, Taiwan
    Am J Epidemiol 176:32-42. 2012
    ..05). Low birth weight predisposes one to develop asthma, and excess body mass amplifies the risk. A sex difference was observed. This study suggests that prenatal care and nutritional counseling could reduce asthma prevalence...
  73. ncbi Spirometric predictors of lung function decline and mortality in early chronic obstructive pulmonary disease
    M Bradley Drummond
    Division of Pulmonary Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 185:1301-6. 2012
    ..The course of lung function decline for smokers with early airflow obstruction remains undefined. It is also unclear which early spirometric characteristics identify individuals at risk for rapid decline and increased mortality...
  74. ncbi Lung clearance index at 4 years predicts subsequent lung function in children with cystic fibrosis
    Paul Aurora
    Portex Respiratory Unit, UCL Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK
    Am J Respir Crit Care Med 183:752-8. 2011
    ..There is an urgent need for alternative surrogates that detect early lung disease and track through early childhood...
  75. ncbi Cardiopulmonary exercise testing characteristics in heart failure patients with and without concomitant chronic obstructive pulmonary disease
    Marco Guazzi
    Cardiopulmonary Laboratory, Cardiology Division, University of Milano, San Paolo Hospital, Milano, Italy
    Am Heart J 160:900-5. 2010
    ....
  76. ncbi Inhaled corticosteroids or long-acting beta-agonists alone or in fixed-dose combinations in asthma treatment: a systematic review of fluticasone/budesonide and formoterol/salmeterol
    Christian Frois
    Analysis Group, Boston, Massachusetts 02199 7636, USA
    Clin Ther 31:2779-803. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting inhaled beta(2)-agonists (LABAs) are recommended treatment options for asthma...
  77. ncbi Chronic obstructive pulmonary disease: CT quantification of airways disease
    Maxime Hackx
    Department of Radiology, Hopital Erasme, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Radiology 265:34-48. 2012
    ..This article details these three approaches and concludes with perspectives and directions for further research...
  78. ncbi Reference values for lung function: past, present and future
    S Stanojevic
    Portex Respiratory Physiology Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Eur Respir J 36:12-9. 2010
    ..We aim to highlight some of the main issues in selecting and using reference equations and discuss how recent developments may improve interpretation of pulmonary function results...
  79. ncbi Interpreting lung function data using 80% predicted and fixed thresholds identifies patients at increased risk of mortality
    David M Mannino
    Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, 121 Washington Ave, Lexington, KY 40536, USA
    Chest 141:73-80. 2012
    ..This study investigated mortality in a representative sample of the US adult population with COPD by comparing abnormality determined using GOLD criteria to that determined using LLN criteria...
  80. pmc The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study
    Victor Kim
    Temple University School of Medicine, Philadelphia, PA 19140, USA
    Chest 140:626-33. 2011
    ..Despite its clinical significance, the chronic bronchitic phenotype in COPD remains poorly defined...
  81. ncbi Exposure to wood smoke particles produces inflammation in healthy volunteers
    Andrew J Ghio
    The National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, North Carolina, USA
    Occup Environ Med 69:170-5. 2012
    ..This investigation tested the postulate that healthy volunteers exposed to WSP would demonstrate evidence of both pulmonary and systemic inflammation...
  82. pmc Impaired respiratory function in mdx and mdx/utrn(+/-) mice
    Ping Huang
    Department of Neurology, Cleveland Clinic, Cleveland, OH 44195, USA
    Muscle Nerve 43:263-7. 2011
    ..The mdx/utrn(+/-) mouse model may be better than the mdx model for testing antifibrotic therapies, especially at the severe stage...
  83. ncbi Two novel mutations in surfactant protein-C, lung function and obstructive lung disease
    Marie Baekvad-Hansen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, Herlev Ringvej 75, DK 2730 Herlev, Copenhagen, Denmark
    Respir Med 104:418-25. 2010
    ..A53T heterozygotes had increased asthma risk, but further research is required to conclusively determine whether this mutation is associated with asthma...
  84. pmc Association between combined interleukin-6 and C-reactive protein levels and pulmonary function in older women: results from the Women's Health and Aging Studies I and II
    SANDY S CHANG
    Section of Geriatrics, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Am Geriatr Soc 59:113-9. 2011
    ....
  85. ncbi Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    Katherine J Baines
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
    J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011
    ..Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell counts; however, few studies have defined transcriptional phenotypes of asthma...
  86. ncbi Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease
    Takefumi Itoh
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Respir Crit Care Med 170:879-82. 2004
    ..In conclusion, plasma ghrelin was elevated in underweight patients with chronic obstructive pulmonary disease, and the level was associated with a cachectic state and abnormality of pulmonary function...
  87. ncbi Relationship between airway wall thickness assessed by high-resolution computed tomography and lung function in patients with asthma and chronic obstructive pulmonary disease
    J Kosciuch
    Department of Internal Medicine, Pneumology and Allergology, Medical University of Warsaw, Poland
    J Physiol Pharmacol 60:71-6. 2009
    ..In COPD, the thickening of airway wall also is related to exposure to tobacco smoke...
  88. ncbi Do family physicians' records fit guideline diagnosed COPD?
    Mieke Albers
    Department of Primary Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Fam Pract 26:81-7. 2009
    ..In family practice, chronic obstructive pulmonary disease (COPD) is usually not diagnosed until clinically apparent and of moderately advanced severity...
  89. ncbi Induced sputum markers of fibrosis and decline in pulmonary function in asbestosis and silicosis: a pilot study
    P Prince
    Centre de Recherche de l Hopital Laval, Institut de cardiologie et de pneumologie de l Université Laval, Quebec, Canada
    Int J Tuberc Lung Dis 12:813-9. 2008
    ..To evaluate the usefulness of fibrogenic cytokines and mediators in the analysis of induced sputum and determine if their levels correlated with previous decline in lung function in asbestosis and silicosis...
  90. pmc Lung volume, breathing pattern and ventilation inhomogeneity in preterm and term infants
    Philipp Latzin
    Division of Respiratory Medicine, Department of Paediatrics, Inselspital and University of Bern, Bern, Switzerland
    PLoS ONE 4:e4635. 2009
    ..Although some studies have shown lower lung volumes and increased ventilation inhomogeneity in BPD infants, conflicting results exist possibly due to differences in sedation and measurement techniques...
  91. ncbi Telomere shortening in chronic obstructive pulmonary disease
    Joyce M J Houben
    Department of Health Risk Analysis and Toxicology, University of Maastricht, The Netherlands
    Respir Med 103:230-6. 2009
    ..05). These data provide evidence for a relationship between a disturbed oxidant/antioxidant balance and telomere shortening and indicate that preservation of fat mass may be protective in delaying telomere shortening in COPD patients...
  92. ncbi Airway inflammation in cystic fibrosis
    Arnon Elizur
    Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin, Israel
    Chest 133:489-95. 2008
    ..Strategies for modulating the airway inflammation in patients with CF are currently under development and may offer new therapeutic options for these patients...
  93. ncbi No increase in the prevalence of COPD in two decades
    T M Vasankari
    Dept of Respiratory Medicine, Turku University Hospital, PL 52, FI 20521, Turku, Finland
    Eur Respir J 36:766-73. 2010
    ..In conclusion, no significant difference was found in the prevalence of COPD stages II-IV between similar population based surveys performed 20 yrs apart. Since COPD is mostly mild or moderate there is a strong case for early prevention...
  94. ncbi Sex differences in emphysema and airway disease in smokers
    Pat G Camp
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Chest 136:1480-8. 2009
    ..The purpose of this study was to test for sex differences in COPD phenotypes by using high-resolution CT (HRCT) scanning in male and female smokers with and without COPD...
  95. ncbi Early pulmonary involvement in ankylosing spondylitis: assessment with thin-section CT
    K Turetschek
    Department of Radiology, University of Vienna, Austria
    Clin Radiol 55:632-6. 2000
    ....
  96. ncbi Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD
    A Di Stefano
    Division of Pulmonary Disease and Laboratory of Cytoimmunopathology of Heart and Lung, Salvatore Maugeri Foundation, IRCCS, Veruno, Italy
    Thorax 64:968-75. 2009
    ..Increased numbers of activated neutrophils have been reported in the bronchial mucosa of patients with stable chronic obstructive pulmonary disease (COPD), particularly in severe disease...
  97. ncbi Prevalence of airflow obstruction in smokers and never-smokers in Switzerland
    P O Bridevaux
    Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva
    Eur Respir J 36:1259-69. 2010
    ..Never-smokers account for a third of the prevalence, which is higher proportion than elsewhere. Airflow obstruction in never-smokers deserves attention because of its frequency and its similar health impact to that in smokers...
  98. ncbi Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening
    Stephen M Stick
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, School of Paediatrics and Child Health, University of Western Australia, Melbourne, Australia
    J Pediatr 155:623-8.e1. 2009
    ..To determine the prevalence of bronchiectasis in young children with cystic fibrosis (CF) diagnosed after newborn screening (NBS) and the relationship of bronchiectasis to pulmonary inflammation and infection...
  99. ncbi Progressive preclinical interstitial lung disease in rheumatoid arthritis
    Bernadette R Gochuico
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1590, Bethesda, MD 20892 1590, USA
    Arch Intern Med 168:159-66. 2008
    ..The objective of this study was to identify asymptomatic lung disease and potential therapeutic targets in patients having RA and preclinical ILD (RA-ILD)...
  100. ncbi Functional status measurement in COPD: a review of available methods and their feasibility in primary care
    Janwillem W H Kocks
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Prim Care Respir J 20:269-75. 2011
    ..This review aims to categorize systematically the available tools based on their construct (i.e. what the tool intends to measure) and to rate the tools for use in the primary care setting...
  101. ncbi Pulmonary involvement in patients with early rheumatoid arthritis
    Z M Metafratzi
    Department of Clinical Radiology and Imaging, Medical School of Patras, Greece
    Scand J Rheumatol 36:338-44. 2007
    ..To assess the pleuropulmonary changes in patients with early rheumatoid arthritis (RA), using high-resolution computed tomography (HRCT)...

Research Grants63

  1. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..In addition, we will actively engage in a process of biomarker discovery and evaluation. ..
  2. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..End of Abstract) ..
  3. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-DCC
    Cynthia D Morris; Fiscal Year: 2013
    ..This research has great public health significance to potentially alter the fetal origins of respiratory disease by blocking some of the effects of in-utero smoke exposure on lung development. ..
  4. Modulation of Genes Responsible for Cilia Length by Exposure to Cigarette Smoke
    Ann E Tilley; Fiscal Year: 2013
    ..An understanding of one of the mechanisms underlying dysfunctional mucociliary clearance in smokers may lead to targets for therapeutic intervention. ..
  5. Novel Protective Antiapoptotic Action of Alpha 1-Antitrypsin In Emphysema
    Rubin M Tuder; Fiscal Year: 2011
    ..abstract_text> ..
  6. XeBox-E10 Gas Polarizer for Functional MRI of Pediatric Lung Disease
    SEAN BEDILION FAIN; Fiscal Year: 2013
    ..To apply ventilation/perfusion MRI to clinical research investigations of early disease in asthma, CF, and BPD, while supporting ongoing studies of adult lung disease and expansion to new opportunities. ..
  7. Imaging regional physiologic parameters of lung function
    Rahim R Rizi; Fiscal Year: 2011
    ....
  8. Community Assessment of Freeway Pollution and Health
    Doug Brugge; Fiscal Year: 2012
    ....
  9. Ph2 of T-Cell Depl Familial Haploidentical SCT for tx Hi-Risk Sickle Cell Anemia
    Mitchell S Cairo; Fiscal Year: 2013
    ..abstract_text> ..
  10. HIV and COPD:Immune mediated mechanisms
    Benjamin D Medoff; Fiscal Year: 2013
    ....
  11. Quantitative Structural and Functional Imaging of the Lung
    Rahim R Rizi; Fiscal Year: 2013
    ..These novel markers will significantly improve understanding of COPD and will be critical to characterizing disease response to therapy. ..
  12. Normal Tissue Complication Modeling for Radiotherapy
    Joseph Deasy; Fiscal Year: 2009
    ....
  13. Fibroblast Cell Signaling in Utero Nicotine-Induced Lung Injury
    Virender K Rehan; Fiscal Year: 2012
    ....
  14. High-Resolution MicroCT Scanner for Cardiopulmonary Imaging Applications
    Rahim R Rizi; Fiscal Year: 2010
    ..Important clinical applications include diagnosis of tumors and other pathologies in various application areas including pulmonary, cardiac, biomechanics and cancer tumors. ..
  15. Late Preterm Birth, Ureaplasma Species and Childhood Lung Disease
    Suhas Kallapur; Fiscal Year: 2012
    ..abstract_text> ..
  16. Stability of Pullmonary Airways
    JAMES BERNARD GROTBERG; Fiscal Year: 2010
    ....
  17. Optimization of Hyperpolarized Xenon-129 Diffusion MRI for COPD
    Chengbo Wang; Fiscal Year: 2013
    ..This will lay the foundation for future clinical trials to evaluate the potential of HP 129Xe diffusion MRI as a fundamentally improved approach for staging and monitoring progression of COPD. ..
  18. An integrative statistics-guided image-based multi-scale lung model
    Ching Long Lin; Fiscal Year: 2013
    ..Human subject studies will be conducted using volumetric 3D lung dual energy computed tomography (DECT) and 99mTc-MPAO-labelled white blood cell (WBC) lung SPECT imaging for model validation and longitudinal studies. ..
  19. Regional Quantification of Lung Function in Cystic Fibrosis using Xe129 MRI
    Jaime Mata; Fiscal Year: 2013
    ..All subjects under this aim will also receive full pulmonary function tests (PFTs) to evaluate the degree of disease severity and to correlate with the results from 3D SB-CSI. ..
  20. Regional Lung Mechanics by 3D Image Registration
    Joseph M Reinhardt; Fiscal Year: 2010
    ..This information is now critical to the development and evaluation of new pulmonary disease therapies. ..
  21. CT-based Biomarker for Diagnosis of COPD Phenotypes and Disease Progression
    Craig J Galban; Fiscal Year: 2013
    ..Overall, it is anticipated that the successful outcome of this effort will significanty improve the diagnostic capability of CT imaging for COPD, leading to improved patient care and a reduction in cost to the healthcare system. ..
  22. Radiation-Induced Cardiopulmonary Injury in Humans
    Lawrence B Marks; Fiscal Year: 2012
    ..This information will lead to algorithms that accurately predict the risk of cardiopulmonary injury, facilitate the design of "safer" 3D dose distributions, and thus improve patient care. ..
  23. Exposure-induced Systemic Oxidative Stress in Children with Asthma
    MELINDA SUE BUTSCH KOVACIC; Fiscal Year: 2010
    ..Consequently, these and planned future efforts will underscore the importance of environmental exposures in asthma treatment, development of diagnostic tools and new evidenced-based environmental policies. ..
  24. Reducing Dynamic Hyperinflation through Breathing Retraining
    Eileen G Collins; Fiscal Year: 2013
    ..Multiple regression analysis will be employed to determine the predictors of improved exercise performance. ..
  25. Couple-Based Mind-Body Program for Lung Cancer Patients and their Partners
    Kathrin Milbury; Fiscal Year: 2013
    ..The training and research activities proposed in this application will help her become an independent researcher capable of obtaining such grant support. ..
  26. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
  27. EPIDEMIOLOGY OF IMMUNOLOGIC LUNG DISEASE
    Kathleen Kreiss; Fiscal Year: 1991
    ..This proposal is the critical step in development of a screening test for the prevention of beryllium disease among the 800,000 Americans who have had industrial exposure to beryllium...
  28. Very-short-time diffusion MRI of hyperpolarized gases
    G Miller; Fiscal Year: 2009
    ..Application of these methods may be used for early detection of serious lung diseases such as emphysema and will provide a tool for medical researchers to better investigate the causes and potential treatments of lung disease. ..
  29. Bronchial Reactivity and the Course of Lung Function After WTC Exposure
    Thomas K Aldrich; Fiscal Year: 2013
    ..The results should define the natural history of WTC-associated OAD, determine whether clinical outcomes varied according to bronchial reactivity, assess the influence of anti- inflammatory treatment on outcomes. ..
  30. IMMUNE REGULATION IN LUNG TRANSPLANTATION
    WILLIAM BURLINGHAM; Fiscal Year: 2003
    ..We will determine how the sensitivity, specificity, and predictive value of each test would be clinically useful in the management of lung transplant patients. ..
  31. Imaging Regional Physiological and Structural Parameters of Airway Remodeling
    Kiarash Emami; Fiscal Year: 2009
    ..Assessment of the sensitivity of these techniques to airway remodeling induced by a murine model of asthma, compared to conventional pulmonary function tests, and validation of measurements against histological gold standard markers. ..
  32. Mentored Patient-Oriented Research Career Development Award
    Ruey Kang Chang; Fiscal Year: 2006
    ..The principal investigator will take advanced courses to enhance knowledge and skills needed for patient-oriented research and work with the mentors to conduct the proposed project during the award period. ..
  33. Development of Hyperpolarized Helium for Assessing ILD
    Milton Rossman; Fiscal Year: 2009
    ..We believe that these measurements can differentiate inflammatory from fibrotic DPLD and will have important diagnostic and prognostic utility in humans ..
  34. RADIATION INDUCED WHOLE & REGIONAL LUNG INJURY IN HUMANS
    Lawrence Marks; Fiscal Year: 2000
    ..While not part of this study, patients enrolled onto this protocol will be included in parallel biological studies designed to consider the molecular biological mechanisms of radiation-induced lung injury. ..
  35. IMPACT OF AEROSOL CYCLOSPORINE IN LUNG TRANSPLANTATION
    Adriana Zeevi; Fiscal Year: 2002
    ..abstract_text> ..
  36. IMMUNOTHERAPY OF CHILDHOOD ASTHMA
    N Adkinson; Fiscal Year: 1993
    ..Finally, the effect of high-dose, long-term immunotherapy on parameters of target cell sensitivity in children will be examined...
  37. Standardized Indices of Breathlessness
    John Baird; Fiscal Year: 2007
    ..The overall goal is to further our understanding about these diseases and to identify better clinical outcome measures. [unreadable] [unreadable] [unreadable]..
  38. R21 PROJECT--EFFICACY OF OSTEOPATHIC MANIPULATION IN COP
    DONALD NOLL; Fiscal Year: 2001
    ..abstract_text> ..
  39. APD to Measure the Resistance of the Respiratory System
    JAFAR VOSSOUGHI; Fiscal Year: 2004
    ..In Phase I work we plan to further develop the system to be battery-operated, low weight, portable, and less expensive. It will be clinically tested on at least 200 individuals. ..
  40. Antibiotics in Infancy-Risk Factor for Childhood Asthma
    Dennis Ownby; Fiscal Year: 2002
    ..This new analysis will allow a much more rigorous examination of the possible relationship between early antibiotic use and asthma in a population of American children. ..
  41. Association Between Asthma and Helminthic Infections
    Maria Araujo; Fiscal Year: 2004
    ....
  42. RANDOMIZED TRIAL OF REHABILITATION IN COPD
    Robert Kaplan; Fiscal Year: 1992
    ..Using the quality of life outcome data and data obtained on costs, we will construct a policy model evaluating the cost/utility of the rehabilitation interventions...
  43. YOGA AND PEAK FLOW RATES IN PREGNANT ASTHMATICS
    Judith Balk; Fiscal Year: 2000
    ..The study is designed as an intent to treat trial, however compliance will be assessed by a prospectively gathered diary which will be blinded until the end of the study. ..
  44. YOGA AND PEAK FLOW RATES IN PREGNANT ASTHMATICS
    Judith Balk; Fiscal Year: 2002
    ..The study is designed as an intent to treat trial, however compliance will be assessed by a prospectively gathered diary which will be blinded until the end of the study. ..
  45. Genetic studies in difficult to treat asthma: TENOR
    Eugene Bleecker; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  46. Noninvasive Ventilation in Children with Cystic Fibrosis
    CAROLE MARCUS; Fiscal Year: 2004
    ..In keeping with the mission of the RFA, this study will use a multidisciplinary approach to improve management and enhance the quality of life in children with chronic respiratory failure. ..
  47. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Robert Wise; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate. To minimize bias, all surviving participants of the LHS will be invited to participated, giving a potential sample size of 5600. ..
  48. MULTIPLE GAS MEASUREMENT OF LUNG TISSUE VOLUME
    GEORGE SWANSON; Fiscal Year: 1980
    ..Theoretical studies will assess the reliability of the technique in maldistribution and the possibility of assessing an index of maldistribution. ..
  49. LUNG PARAMETERS FROM RESPIRATORY IMPEDANCE MEASUREMENTS
    Andrew Jackson; Fiscal Year: 1992
    ..2 -200 Hz in healthy and sick children ages 42 months to 18 years. The statistical reliability and physiological appropriateness of parameters in inverse models applied to such data will be determined...
  50. PHYSICAL GROWTH IN PATIENTS WITH CYSTIC FIBROSIS
    PAMELA BYARD; Fiscal Year: 1990
    ....
  51. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP DATA COORD CTR
    John Connett; Fiscal Year: 2002
    ....
  52. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP
    Robert Rogers; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  53. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    MURRAY ALTOSE; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  54. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP
    Michael Eichenhorn; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  55. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP
    ALINE BUIST; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  56. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP
    Paul Scanlon; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  57. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Nicholas Anthonisen; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  58. LUNG HEALTH STUDY--LONG TERM FOLLOW-UP
    RICHARD KANNER; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate. Of minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  59. Tissue Tagging MRI of Regional Lung Mechanics
    Qun Chen; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. MULTI-CNTER PHASE 2 TRIAL OF ORAL TYPE I BOVINE COLLAGE
    Arnold Postlethwaite; Fiscal Year: 2000
    ..In addition, studies are proposed to explore the underlying mechanisms that mediate a potential effect of oral collagen peptides in the immune pathogenesis of SSc. ..
  61. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Donald Tashkin; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate in this study. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  62. SCLERODERMA LUNG STUDY
    Donald Tashkin; Fiscal Year: 2003
    ..abstract_text> ..
  63. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2008
    ..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..