pulse

Summary

Summary: The rhythmical expansion and contraction of an ARTERY produced by waves of pressure caused by the ejection of BLOOD from the left ventricle of the HEART as it contracts.

Top Publications

  1. ncbi Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity
    Luc M Van Bortel
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    J Hypertens 30:445-8. 2012
  2. ncbi Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement
    Akira Yamashina
    Second Department of Internal Medicine, Tokyo Medical University, Japan
    Hypertens Res 25:359-64. 2002
  3. ncbi Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population
    Tine Willum-Hansen
    Research Center for Prevention and Health, Copenhagen, Denmark
    Circulation 113:664-70. 2006
  4. ncbi Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement--a survey of 12517 subjects
    Hirofumi Tomiyama
    The Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Atherosclerosis 166:303-9. 2003
  5. ncbi Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity
    A Benetos
    Center Investigations Preventives et Cliniques, INSERM U337, Paris, France
    Hypertension 37:381-5. 2001
  6. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
  7. ncbi Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Circulation 111:3384-90. 2005
  8. ncbi Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT)
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Coll Cardiol 46:1753-60. 2005
  9. ncbi Brachial-ankle pulse wave velocity: an index of central arterial stiffness?
    J Sugawara
    Institute for Human Science and Bioengineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
    J Hum Hypertens 19:401-6. 2005
  10. ncbi Assessing fluid responsiveness in critically ill patients: False-positive pulse pressure variation is detected by Doppler echocardiographic evaluation of the right ventricle
    Yazine Mahjoub
    Medical YM, CP, AF, El, Ft, CG, HD and Surgical Intensive Care Unit EZ, Department of Anesthesia and Intensive Care, Amiens University Hospital, Amiens, France
    Crit Care Med 37:2570-5. 2009

Detail Information

Publications339 found, 100 shown here

  1. ncbi Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity
    Luc M Van Bortel
    Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
    J Hypertens 30:445-8. 2012
    ..having the best predictive value for cardiovascular outcome and the ease of its measurement, carotid-femoral pulse wave velocity is now considered the gold standard for arterial stiffness assessment in daily practice...
  2. ncbi Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement
    Akira Yamashina
    Second Department of Internal Medicine, Tokyo Medical University, Japan
    Hypertens Res 25:359-64. 2002
    The present study was conducted to evaluate the validity and reproducibility of noninvasive brachial-ankle pulse wave velocity (baPWV) measurements and to examine the alteration of baPWV in patients with coronary artery disease (CAD)...
  3. ncbi Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population
    Tine Willum-Hansen
    Research Center for Prevention and Health, Copenhagen, Denmark
    Circulation 113:664-70. 2006
    Few population studies addressed the prognostic significance of aortic pulse wave velocity (APWV) above and beyond other cardiovascular risk factors.
  4. ncbi Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement--a survey of 12517 subjects
    Hirofumi Tomiyama
    The Second Department of Internal Medicine, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Atherosclerosis 166:303-9. 2003
    ..study was conducted to evaluate the influences of age and gender on the results of noninvasive brachial-ankle pulse wave velocity (baPWV)...
  5. ncbi Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity
    A Benetos
    Center Investigations Preventives et Cliniques, INSERM U337, Paris, France
    Hypertension 37:381-5. 2001
    ..provides a better account than chronological age for variation in arterial stiffness, evaluated by measuring pulse pressure and aortic pulse wave velocity...
  6. ncbi Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
    ..Aortic stiffness was determined from carotid-femoral pulse wave velocity at baseline in 1045 hypertensives...
  7. ncbi Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Circulation 111:3384-90. 2005
    ..Increased aortic pulse wave velocity (aPWV) has been associated with mortality in clinical but not general populations...
  8. ncbi Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT)
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Coll Cardiol 46:1753-60. 2005
    ....
  9. ncbi Brachial-ankle pulse wave velocity: an index of central arterial stiffness?
    J Sugawara
    Institute for Human Science and Bioengineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
    J Hum Hypertens 19:401-6. 2005
    Brachial-ankle pulse wave velocity (baPWV) is a promising technique to assess arterial stiffness conveniently. However, it is not known whether baPWV is associated with well-established indices of central arterial stiffness...
  10. ncbi Assessing fluid responsiveness in critically ill patients: False-positive pulse pressure variation is detected by Doppler echocardiographic evaluation of the right ventricle
    Yazine Mahjoub
    Medical YM, CP, AF, El, Ft, CG, HD and Surgical Intensive Care Unit EZ, Department of Anesthesia and Intensive Care, Amiens University Hospital, Amiens, France
    Crit Care Med 37:2570-5. 2009
    ..Sta), a right ventricular function parameter, can discriminate patients with true- and false-positive pulse pressure variation...
  11. ncbi Effects of electrical acupuncture on acupoint BL15 evaluated in terms of heart rate variability, pulse rate variability and skin conductance response
    Chih Chieh Hsu
    Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, Taiwan
    Am J Chin Med 34:23-36. 2006
    In this research, heart rate variability (HRV), pulse rate variability (PRV) and human skin conductance (SC) of all acupoints on Heart Meridian were used to evaluate the effects of electrical acupuncture (EA) on acupoint BL15 (Bladder ..
  12. ncbi Impact of brachial-ankle pulse wave velocity and ankle-brachial blood pressure index on mortality in hemodialysis patients
    Tokuyuki Kitahara
    Department of Medicine and Clinical Science, Gunma Graduate School of Medicine, Maebashi, Japan
    Am J Kidney Dis 46:688-96. 2005
    b>Pulse wave velocity (PWV) and ankle-brachial blood pressure index (ABPI) are markers for atherosclerosis, and each predicts mortality in patients undergoing hemodialysis...
  13. ncbi Salt sensitivity, pulse pressure, and death in normal and hypertensive humans
    M H Weinberger
    Indiana University School of Medicine, The Regenstrief Institute for Health Care, Roudebush Veteran s Administration Medical Center, Indianapolis, Indiana, USA
    Hypertension 37:429-32. 2001
    ..002) associated with subjects who had died compared with subjects known to be alive: age at study, pulse pressure, systolic, diastolic, and mean arterial pressures, hypertension, salt sensitivity, baseline renin levels, ..
  14. ncbi Pulse pressure and risk of new-onset atrial fibrillation
    Gary F Mitchell
    Cardiovascular Engineering Inc, Waltham, Mass 02453, USA
    JAMA 297:709-15. 2007
    ..Increased pulse pressure, a reflection of aortic stiffness, increases cardiac load and may increase AF risk.
  15. ncbi Central pulse pressure and mortality in end-stage renal disease
    Michel E Safar
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 39:735-8. 2002
    ..Increased aortic pulse wave velocity (PWV) and brachial pulse pressure (PP) are the principal arterial markers of cardiovascular ..
  16. ncbi Systolic blood pressure, diastolic blood pressure, and pulse pressure as predictors of risk for congestive heart failure in the Framingham Heart Study
    Agha W Haider
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts 01702 5827, USA
    Ann Intern Med 138:10-6. 2003
    Although hypertension is a principal precursor of congestive heart failure (CHF), the separate relations of systolic, diastolic, and pulse pressure with risk for heart failure have not been fully elucidated.
  17. ncbi Analysis of cardiovascular responses to passive head-up tilt using continuous pulse wave analysis and impedance cardiography
    Anna Tahvanainen
    Department of Internal Medicine, University of Tampere, Tampere, Finland
    Scand J Clin Lab Invest 69:128-37. 2009
    ....
  18. pmc Assessment of endothelial function using digital pulse amplitude tonometry
    Naomi M Hamburg
    Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Trends Cardiovasc Med 19:6-11. 2009
    ..A novel pulse amplitude tonometry device noninvasively measures vasodilator function in the microcirculation of the finger...
  19. ncbi Arterial blood pressure measurement and pulse wave analysis--their role in enhancing cardiovascular assessment
    Alberto P Avolio
    The Australian School of Advanced Medicine, Macquarie University, Sydney, Australia
    Physiol Meas 31:R1-47. 2010
    ..Since the arterial pressure pulse becomes modified as it travels away from the heart towards the periphery, this is generally true for mean and ..
  20. ncbi Brachial -- ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome
    Hirofumi Tomiyama
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan
    Circ J 69:815-22. 2005
    Although a very simple method of measuring brachial -- ankle pulse wave velocity (baPWV) has become available in a clinical setting, whether baPWV can predict future cardiovascular events remains uncertain...
  21. ncbi Left ventricular mass in patients with type 2 diabetes is independently associated with central but not peripheral pulse pressure
    James E Sharman
    University of Queensland, Department of Medicine, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4102, Australia
    Diabetes Care 28:937-9. 2005
  22. ncbi Ambulatory pulse pressure, decreased nocturnal blood pressure reduction and progression of nephropathy in type 2 diabetic patients
    S T Knudsen
    Medical Department M Diabetes and Endocrinology, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus C, Denmark
    Diabetologia 52:698-704. 2009
    We followed type 2 diabetic patients over a long period to evaluate the predictive value of ambulatory pulse pressure (PP) and decreased nocturnal BP reduction (non-dipping) for nephropathy progression.
  23. ncbi [Relationship between pulse pressure, visual impairement and severity of diabetic retinopathy in sub-Saharan Africa]
    A Nsungu J Nkondi Mbadi
    Service d Ophtalmologie, Hôpital Général de référence de Kinshasa et Université de Kinshasa, RD Congo
    Mali Med 24:17-21. 2009
    To determine the relationship between pulse pressure, traditional risk factors, vision impairment and different clinical forms of diabetic retinopathy.
  24. ncbi Comparison of a non-invasive arterial pulse contour technique and echo Doppler aorta velocity-time integral on stroke volume changes in optimization of cardiac resynchronization therapy
    Irene E van Geldorp
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Europace 13:87-95. 2011
    We investigated the accuracy and feasibility of a non-invasive arterial pulse contour technique for continuous measurement of stroke volume (SV) in optimization of atrioventricular (AV) delay in cardiac resynchronization therapy (CRT), ..
  25. ncbi Relationship between brachial-ankle pulse wave velocity and cardiovascular risk factors of the metabolic syndrome
    K M Choi
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University Guro Hospital, Korea University, 80 Guro dong, Guro Gu, Seoul 152 050, South Korea
    Diabetes Res Clin Pract 66:57-61. 2004
    In this study, we investigated the association between brachial-ankle pulse wave velocity (baPWV), a novel non-invasive means of measuring atherosclerosis, and the cardiovascular risk factors of the metabolic syndrome...
  26. ncbi Validation of a new non-invasive portable tonometer for determining arterial pressure wave and pulse wave velocity: the PulsePen device
    Paolo Salvi
    Department of Internal Medicine, Bufalini Hospital, Cesena, Italy
    J Hypertens 22:2285-93. 2004
    ..To validate a new, small portable tonometer (PulsePen) that is able to assess carotid artery pressure and to measure pulse wave velocity (PWV) non-invasively...
  27. ncbi Individualization of transfer function in estimation of central aortic pressure from the peripheral pulse is not required in patients at rest
    Berend E Westerhof
    BMEYE B V, Academic Medical Center, Suite K2 245, Univ of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Appl Physiol (1985) 105:1858-63. 2008
    ..Details of the wave shape were reproduced slightly better with ITF but not significantly, thus individualization of pressure transfer is not effective in resting patients...
  28. ncbi Photoplethysmographic assessment of pulse wave reflection: blunted response to endothelium-dependent beta2-adrenergic vasodilation in type II diabetes mellitus
    P J Chowienczyk
    Department of Clinical Pharmacology, Centre for Cardiovascular Biology and Medicine, King s College, London, United Kingdom
    J Am Coll Cardiol 34:2007-14. 1999
    We sought to determine whether a simple index of pressure wave reflection may be derived from the digital volume pulse (DVP) and used to examine endothelium-dependent vasodilation in patients with type II diabetes mellitus.
  29. ncbi Indices of cardiovascular function derived from peripheral pulse wave analysis using radial applanation tonometry: a measurement repeatability study
    Mike Crilly
    Department of Public Health, University of Aberdeen Medical School, Aberdeen, UK mike crilly abdn ac uk
    Vasc Med 12:189-97. 2007
    b>Pulse wave analysis (PWA) using applanation tonometry is a non-invasive technique for assessing cardiovascular function...
  30. ncbi Galen: on blood, the pulse, and the arteries
    Michael Boylan
    Department of Philosophy, Marvmount University, 2807 N Globe Road, Arlington, VA 22207, USA
    J Hist Biol 40:207-30. 2007
    ..In the process some of Galen's supporting doctrines on the blood and pulse will also be discussed in the context of a coherent scientific explanation...
  31. ncbi Contour analysis of the photoplethysmographic pulse measured at the finger
    Sandrine C Millasseau
    Cardiovascular Division, King s College London School of Medicine, London, UK
    J Hypertens 24:1449-56. 2006
    Analysis of the contour of the peripheral pulse to assess arterial properties was first described in the nineteenth century...
  32. ncbi Endothelial pulse amplitude testing: feasibility and reproducibility in adolescents
    Elif Seda Selamet Tierney
    Department of Cardiology, Children s Hospital, Boston, MA 02155, USA
    J Pediatr 154:901-5. 2009
    To test prospectively the reproducibility and feasibility of endothelial pulse amplitude testing (Endo-PAT), a novel Food and Drug Administration-approved technology, in healthy adolescents.
  33. ncbi Relations of central and brachial blood pressure to left ventricular hypertrophy and geometry: the Strong Heart Study
    Mary J Roman
    Division of Cardiology, Weill Cornell Medical College, New York 10021, USA
    J Hypertens 28:384-8. 2010
    We previously demonstrated stronger relations of central vs. brachial blood pressure, particularly pulse pressure, to carotid artery hypertrophy and extent of atherosclerosis...
  34. ncbi Increased pulse wave velocity is not associated with elevated augmentation index in patients with diabetes
    Peter S Lacy
    Department of Cardiovascular Sciences, Cardiovascular Research Institute, University of Leicester, Leicester LE2 7LX, UK
    J Hypertens 22:1937-44. 2004
    Increased arterial stiffness is a risk factor for cardiovascular disease and is a feature associated with diabetes. Pulse wave velocity (PWV) is an accepted index of arterial stiffness and augmentation index (AI) derived from radial ..
  35. ncbi Excess mortality associated with increased pulse pressure among middle-aged men and women is explained by high systolic blood pressure
    R L Antikainen
    Health Center Hospital of Oulu and Department of Internal Medicine, Oulu University, Finland
    J Hypertens 18:417-23. 2000
    To assess the risk of death from coronary heart disease, stroke, all cardiovascular diseases and all-cause mortality associated with pulse pressure among the middle-aged population.
  36. ncbi Association between pulse pressure and C-reactive protein among apparently healthy US adults
    Jerome L Abramson
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30306, USA
    Hypertension 39:197-202. 2002
    Elevated pulse pressure has been associated with an increased risk of cardiovascular disease, which is increasingly being seen as an inflammatory disease...
  37. ncbi Validating a new oscillometric device for aortic pulse wave velocity measurements in children and adolescents
    Daniela Kracht
    Department of Pediatric Nephrology, Hannover Medical School, Hannover, Germany
    Am J Hypertens 24:1294-9. 2011
    b>Pulse wave velocity (PWV) is an indicator of aortic stiffness and a predictor of cardiovascular risk. Applanation tonometry (e.g., SphygmoCor) is a well-established method to measure aortic PWV (aPWV)...
  38. ncbi The influence of serum aldosterone and the aldosterone-renin ratio on pulse wave velocity in hypertensive patients
    Sungha Park
    Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea
    J Hypertens 25:1279-83. 2007
    ..Excess aldosterone may have a detrimental effect on vascular stiffness. We therefore hypothesized that ARR and aldosterone are independently correlated with pulse wave velocity (PWV) in hypertensive patients.
  39. ncbi Variability of body weight, pulse pressure and glycaemia strongly predict total mortality in elderly type 2 diabetic patients. The Verona Diabetes Study
    Giacomo Zoppini
    Division of Endocrinology and Metabolic Diseases, University of Verona, Verona, Italy
    Diabetes Metab Res Rev 24:624-8. 2008
    ..the impact of long-term exposure to the average value (mean) or to the variability (coefficient of variation) of fasting glycaemia, body mass index (BMI) and pulse pressure on total mortality in a cohort of type 2 diabetic patients.
  40. ncbi Estimation of ocular rigidity based on measurement of pulse amplitude using pneumotonometry and fundus pulse using laser interferometry in glaucoma
    Anton Hommer
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 49:4046-50. 2008
    ..In this study, the hypothesis was that patients with primary open-angle glaucoma (POAG) have an abnormal ocular structural stiffness based on measurements of intraocular pressure amplitude and ocular fundus pulsation amplitude (FPA)...
  41. ncbi Deriving respiration from photoplethysmographic pulse width
    Jesus Lazaro
    Communications Technology Group, Aragon Institute of Engineering Research, IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain
    Med Biol Eng Comput 51:233-42. 2013
    A method for deriving respiration from the pulse photoplethysmographic (PPG) signal is presented...
  42. ncbi Pulse pressure, arterial stiffness, and drug treatment of hypertension
    L M van Bortel
    Department of Clinical Pharmacology and Pharmacotherapy, Heymans Institute for Pharmacology, University of Ghent, Ghent, Belgium
    Hypertension 38:914-21. 2001
    Epidemiological studies in the past decade have stressed the importance of pulse pressure as an independent risk factor for cardiovascular morbidity and mortality...
  43. ncbi Value of beat-to-beat blood pressure changes, detected by pulse transit time, in the management of the obstructive sleep apnoea/hypopnoea syndrome
    D J Pitson
    Osler Chest Unit, The Churchill, Oxford Radcliffe Hospital, UK
    Eur Respir J 12:685-92. 1998
    ..These can be derived from an indirect estimate of beat-to-beat blood pressure (BP), pulse transit time (PTT)...
  44. ncbi Perfused, pulseless, and puzzling: a systematic review of vascular injuries in pediatric supracondylar humerus fractures and results of a POSNA questionnaire
    Lydia White
    Division of Pediatric Orthopaedic Surgery, Cincinnati Children s Medical Center, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Pediatr Orthop 30:328-35. 2010
    Supracondylar humerus fractures that present with a perfused, viable hand yet no pulse continue to be a source of controversy...
  45. ncbi Ischaemia and the pink, pulseless hand complicating supracondylar fractures of the humerus in childhood: long-term follow-up
    C M Blakey
    Research and Education, South West London Elective Orthopaedic Centre, Dorking Road, Epsom KT18 7EG, UK
    J Bone Joint Surg Br 91:1487-92. 2009
    ....
  46. ncbi Brachial-ankle pulse wave velocity predicts silent cerebrovascular diseases in patients with end-stage renal diseases
    Naoki Washida
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Atheroscler Thromb 17:165-72. 2010
    ..The purpose of this study was to examine whether factors associated with arterial stiffness contributed to the development of CVD in patients with ESRD...
  47. ncbi Pink pulseless hand following supra-condylar fractures: an audit of British practice
    Ajay Malviya
    Trauma and Orthopaedics Birmingham Children s Hospital, Birmingham, UK
    J Pediatr Orthop B 15:62-4. 2006
    ..In the absence of a radial pulse, stabilization would be considered even after midnight...
  48. ncbi Reference values of pulse wave velocity in healthy children and teenagers
    George S Reusz
    First Department of Pediatrics, Semmelweis University, Budapest, Budapest, Hungary
    Hypertension 56:217-24. 2010
    Carotid-femoral pulse wave velocity is an established method for characterizing aortic stiffness, an individual predictor of cardiovascular mortality in adults...
  49. ncbi Non-contact, automated cardiac pulse measurements using video imaging and blind source separation
    Ming Zher Poh
    Divison of Health Sciences and Technology, Harvard MIT, Cambridge, MA 02139, USA
    Opt Express 18:10762-74. 2010
    Remote measurements of the cardiac pulse can provide comfortable physiological assessment without electrodes. However, attempts so far are non-automated, susceptible to motion artifacts and typically expensive...
  50. ncbi Subclinical atherosclerosis is increased in type 2 diabetic patients with microalbuminuria evaluated by intima-media thickness and pulse wave velocity
    Hiroki Yokoyama
    Jiyugaoka Clinic, Internal Medicine, Obihiro, Japan
    Kidney Int 66:448-54. 2004
    ..Microalbuminuria appears to be a risk marker for atherosclerosis. However, little is known about the direct association between microalbuminuria and vascular wall properties...
  51. pmc Variation associated with measurement of retinal vessel diameters at different points in the pulse cycle
    M D Knudtson
    UW Madison Department of Ophthalmology and Visual Sciences, University of Wisconsin, 610 N Walnut Street, 4th Floor WARF, Madison, WI 53726, USA
    Br J Ophthalmol 88:57-61. 2004
    To assess the variability in retinal vessel measurements at different points in the pulse cycle.
  52. ncbi Bootstrap quantification of cardiac pulsation artifact in DTI
    SungWon Chung
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, CA, USA
    Neuroimage 49:631-40. 2010
    ..We have demonstrated that cardiac gating, especially of partial Fourier acquisitions, can reduce the uncertainties of DTI derived parameters in a time-efficient manner...
  53. ncbi Brachial-ankle pulse wave velocity and metabolic syndrome in a Japanese population: the Minoh study
    Noriyuki Nakanishi
    Department of Social and Environmental Medicine, Course of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 28:125-31. 2005
    To investigate the association between brachial-ankle pulse wave velocity (baPWV) and metabolic syndrome (MS), we examined 374 men and 622 women aged 40 to 69 years who did not have a past history of either coronary heart disease or ..
  54. pmc Measurement of blood pressure using an arterial pulsimeter equipped with a Hall device
    Sang Suk Lee
    Department of Oriental Biomedical Engineering, Sangji University, Wonju 220 702, Korea
    Sensors (Basel) 11:1784-93. 2011
    To measure precise blood pressure (BP) and pulse rate without using a cuff, we have developed an arterial pulsimeter consisting of a small, portable apparatus incorporating a Hall device...
  55. ncbi Pulse pressure--a review of mechanisms and clinical relevance
    A M Dart
    Alfred Baker Medical Unit, Alfred Hospital and Baker Medical Research Institute, Melbourne, Australia
    J Am Coll Cardiol 37:975-84. 2001
    The goal of this study was to review the origin, clinical relevance and treatment of pulse pressure (PP). Elevated PP is increasingly being recognized as a risk factor for cardiovascular, particularly coronary, disease...
  56. ncbi Covert respiration measures for the detection of concealed information
    Eitan Elaad
    Ariel University Center, Ariel, Israel
    Biol Psychol 77:284-91. 2008
    ..standard measures typically used for the detection of concealed knowledge (electrodermal, respiration and finger pulse measures)...
  57. ncbi Should pulse pressure and day/night variations in blood pressure be seen as independent risk factors requiring correction or simply as markers to be taken into account when evaluating overall vascular risk?
    B Bouhanick
    Service de médecine interne et HTA, CHU de Rangueil, TSA 50032, 31059, Toulouse Cedex 9, France
    Diabetes Metab 33:321-30. 2007
    ..In the diabetic population, brachial pulse pressure (PP) is an independent predictor of cardiovascular mortality, but not of all-cause mortality...
  58. ncbi [Influence of open chest conditions on pulse pressure variations]
    E Lorne
    Pole Anesthésie Réanimation, CHU d Amiens, 1 place Victor Pauchet, Amiens, France
    Ann Fr Anesth Reanim 30:117-21. 2011
    b>Pulse pressure variations are used to assess fluid responsiveness in mechanically ventilated patients. The accuracy of this index in open chest conditions remained unclear...
  59. ncbi Determinants of the second derivative of the finger photoplethysmogram and brachial-ankle pulse-wave velocity: the Ohasama study
    Junichiro Hashimoto
    Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan
    Am J Hypertens 18:477-85. 2005
    ..different characteristics of the second derivative of the finger photoplethysmogram (SDPTG) and brachial-ankle pulse wave velocity (BAPWV) for assessing arterial function in a large general population, along with the alteration of ..
  60. ncbi The validity of finger pulse line length for the detection of concealed information
    Katrien Vandenbosch
    Department of Psychology, Ghent University, Henri Dunantlaan 2, B 9000 Ghent, Belgium
    Int J Psychophysiol 71:118-23. 2009
    ..amp; Ben-Shakhar, G. (2006). Finger pulse waveform length in the detection of concealed information. Int. J. Psychophysiol., 61, 226-234...
  61. ncbi Pulse pressure and risk for myocardial infarction and heart failure in the elderly
    V Vaccarino
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    J Am Coll Cardiol 36:130-8. 2000
    We sought to determine whether pulse pressure (PP), a measure of arterial stiffness, is an independent predictor of the incidence of coronary heart disease (CHD), congestive heart failure (CHF) and overall mortality among community-..
  62. ncbi Pulse-wave morphology and pulse-wave velocity in healthy human volunteers: examination conditions
    M Frimodt-Møller
    Department of Nephrology, Herlev University Hospital, Herlev, Denmark
    Scand J Clin Lab Invest 66:385-94. 2006
    Applanation tonometry for pulse-wave analysis (PWA) and determination of pulse-wave velocity (PWV) is a non-invasive method for assessment of the central aortic pressure waveform and indices of arterial stiffness...
  63. ncbi The difference in pulse transit time to the toe and finger measured by photoplethysmography
    M Nitzan
    Department of Applied Physics Electro Optics, Jerusalem College of Technology, Israel
    Physiol Meas 23:85-93. 2002
    Blood pressure pulse wave velocity (PWV) is a parameter which is related to arterial distensibility...
  64. ncbi Impact of smoking and smoking cessation on arterial stiffness and aortic wave reflection in hypertension
    Noor A Jatoi
    Department of Pharmacology and Therapeutics, Trinity Centre for Health Sciences, St James s Hospital, Dublin 8, Ireland
    Hypertension 49:981-5. 2007
    ..Measurements included aortic stiffness, assessed as pulse wave velocity (Complior), wave reflection (augmentation index [AIx]), and transit time (T(R)) (Sphygmocor)...
  65. ncbi Increased stroke volume and aortic stiffness contribute to isolated systolic hypertension in young adults
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Hypertension 46:221-6. 2005
    ..Peripheral and central blood pressure, aortic pulse wave velocity, cardiac output, stroke volume, and peripheral vascular resistance were determined in 1008 subjects, ..
  66. ncbi Increased pulse wave velocity associated with reduced calcaneal quantitative osteo-sono index: possible relationship between atherosclerosis and osteopenia
    Ken ichi Hirose
    Second Department of Internal Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
    J Clin Endocrinol Metab 88:2573-8. 2003
    ..Thus, we measured pulse wave velocity (PWV), which reflects earlier phase atherosclerosis, and osteo-sono assessment index (OSI), which ..
  67. ncbi Pulse pressure and coronary mortality in elderly men and women from general population
    E Casiglia
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani, 2 35128 Padova, Italy
    J Hum Hypertens 16:611-20. 2002
    The aim of this work was to evaluate whether pulse pressure (PP) in elderly people is a better predictor of coronary mortality than systolic and diastolic blood pressure taken alone...
  68. ncbi Pulse wave velocity and augmentation index, but not intima-media thickness, are early indicators of vascular damage in hypercholesterolemic children
    S Riggio
    Department of Internal Medicine and Medical Therapy, University of Messina, 8298123 Messina, Italy
    Eur J Clin Invest 40:250-7. 2010
    ..Aim of our study was to evaluate local and systemic arterial stiffness as well as carotid intima-media thickness (IMT) in HCh children and also to investigate the relation between serum cholesterol levels and arterial stiffness...
  69. ncbi Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice
    Y X Wang
    Department of Pharmacology, Berlex Biosciences, Richmond, California 94804, USA
    Am J Physiol Heart Circ Physiol 278:H428-34. 2000
    ..A direct consequence of atherosclerosis is an increase in vascular stiffness. Pulse wave velocity (PWV) has been used to assess the stiffness of large vessels and was found to be increased in ..
  70. pmc Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort
    Stephanie S DeLoach
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Hypertens 22:1235-41. 2009
    ..This study was designed to assess the association between two noninvasive measures of cardiovascular risk, pulse wave analysis (PWA), and carotid intima-media thickness (IMT), in a cohort of CKD patients enrolled in the Chronic ..
  71. ncbi Ambulatory arterial stiffness index, pulse wave velocity and augmentation index--interchangeable or mutually exclusive measures?
    Paula Jerrard-Dunne
    Department of Pharmacology and Therapeutics, Trinity College Dublin, Trinity Centre, St James s Hospital, Dublin, Ireland
    J Hypertens 26:529-34. 2008
    ..This index has prompted considerable controversy as to whether it is a true measure of arterial stiffness...
  72. ncbi Pulse waveform characteristics predict cardiovascular events and mortality in patients undergoing coronary angiography
    Thomas Weber
    Cardiology Department, Klinikum Wels Grieskirchen, Wels, Austria
    J Hypertens 28:797-805. 2010
    b>Pulse waveform characteristics (Augmentation Index--AIx and pulse wave transit time) are measures of the timing and extent of arterial wave reflections...
  73. ncbi Non-invasive radial pulse wave assessment for the evaluation of left ventricular systolic performance in heart failure
    Jean Michel Tartiere
    Department of Physiology, Lariboisiere Hospital, Assistance Publique, Paris, France
    Eur J Heart Fail 9:477-83. 2007
    ..We sought to assess the reproducibility and feasibility of use of the maximal first derivative of the radial pulse, Rad dP/dt, as a peripheral criterion of ventricular contractility in patients with heart failure.
  74. ncbi Pulmonary artery pulse pressure and wave reflection in chronic pulmonary thromboembolism and primary pulmonary hypertension
    V Castelain
    Service de Pneumologie, , , Assistance Publique-H pitaux de Paris, Clamart, France
    J Am Coll Cardiol 37:1085-92. 2001
    OBJECTIVES: The purpose of this time-domain study was to compare pulmonary artery (PA) pulse pressure and wave reflection in chronic pulmonary thromboembolism (CPTE) and primary pulmonary hypertension (PPH)...
  75. ncbi Wrist pulse signal diagnosis using modified Gaussian models and Fuzzy C-Means classification
    Yinghui Chen
    Biometrics Research Center, Dept of Computing, The Hong Kong Polytechnic University, Hong Kong, China
    Med Eng Phys 31:1283-9. 2009
    Wrist pulse signal contains important information about the health status of a person and pulse signal diagnosis has been employed in oriental medicine for thousands of years...
  76. ncbi Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations
    R Asmar
    L'Institut CardioVasculaire, Paris, France
    Am J Hypertens 14:91-7. 2001
    BACKGROUND: Pulse pressure (PP) and aortic pulse wave velocity (PWV) are significant markers of cardiovascular risk, but a similar role for central wave reflections has never been investigated...
  77. pmc Hemodynamic correlates of blood pressure across the adult age spectrum: noninvasive evaluation in the Framingham Heart Study
    Gary F Mitchell
    Cardiovascular Engineering Inc, 1 Edgewater Drive, Norwood, MA 02062, USA
    Circulation 122:1379-86. 2010
    Systolic blood pressure and pulse pressure are substantially higher in older adults...
  78. ncbi Aortic pulse wave velocity is associated with the presence and quantity of coronary artery calcium: a community-based study
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hypertension 47:174-9. 2006
    We investigated the relationship of aortic pulse wave velocity (aPWV), a measure of central arterial stiffness, with the presence and quantity of coronary artery calcium (CAC) in a community-based sample of adults without prior history ..
  79. ncbi The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging
    Oliver J Rider
    Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Obesity (Silver Spring) 18:2311-6. 2010
    ..the effect of obesity and weight loss, in the absence of the traditional cardiovascular risk factors, on aortic pulse wave velocity (PWV) a reliable, reproducible, and accurate clinical measure of aortic stiffness linked to ..
  80. ncbi Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients
    O H Ryu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, 80 Guro dong, Guro Gu, Seoul 152 050, South Korea
    Diabetes Res Clin Pract 71:356-8. 2006
    ..Furthermore, tea consumption did not improve baPWV. These results suggest that the above-described mechanisms are unlikely to explain the cardiovascular risk reduction by tea consumption observed in epidemiological studies...
  81. ncbi Association of pulse wave velocity with vascular and valvular calcification in hemodialysis patients
    P Raggi
    Division of Cardiology and Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA, and Department of Nephrology, Ospedale San Paolo, Milan, Italy
    Kidney Int 71:802-7. 2007
    ..Accordingly, in 131 adult maintenance hemodialysis patients, we investigated the association of aortic pulse wave velocity (PWV) with calcification of cardiac valves on echocardiography, coronary artery, and thoracic aorta ..
  82. ncbi Midlife pulse pressure and incidence of dementia: the Honolulu-Asia Aging Study
    Michael H Freitag
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    Stroke 37:33-7. 2006
    ..This study explores whether this association is attributable to the pulsatile, ie, pulse pressure (PP), or the nonpulsatile component of blood pressure (BP).
  83. ncbi A simple oscillometric technique for determining new indices of arterial distensibility
    Tadahiro Kubo
    First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan
    Hypertens Res 25:351-8. 2002
    Recently, oscillometric devices have been developed that can measure blood pressure in the extremities and analyze pulse volume record...
  84. ncbi Finger pulse waveform length in the detection of concealed information
    Eitan Elaad
    Department of Behavioral Sciences, The College of Judea and Samaria, Ariel, Israel
    Int J Psychophysiol 61:226-34. 2006
    An attempt was made to assess the efficiency of the finger pulse waveform length (FPWL), in detection of concealed information. For this purpose, two mock-theft experiments were designed...
  85. ncbi Pulse pressure and diurnal blood pressure variation: association with micro- and macrovascular complications in type 2 diabetes
    Søren Tang Knudsen
    Medical Department M Diabetes and Endocrinology, Aarhus Kommunehospital, Aarhus, Denmark
    Am J Hypertens 15:244-50. 2002
    In nondiabetic subjects pulse pressure (PP) is an independent predictor of cardiovascular disease and microalbuminuria...
  86. ncbi Aortic pulse wave velocity and albuminuria in patients with type 2 diabetes
    Andrew Smith
    Unit for Metabolic Medicine, 5th Floor, Department of Diabetes and Endocrinology, Cardiovascular Division, GKT School of Medicine, King s College London, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
    J Am Soc Nephrol 16:1069-75. 2005
    ..Aortic pulse wave velocity (Ao-PWV) and albumin creatinine ratio (ACR) were measured in 134 consecutive patients with type 2 ..
  87. ncbi Feasibility of aortic pulse pressure and pressure wave velocity MRI measurement in young adults
    Eric Laffon
    Service de Medecine Nucleaire, Hopital du Haut leveque, Pessac, France
    J Magn Reson Imaging 21:53-8. 2005
    To investigate the feasibility of assessing, noninvasively, aortic pulse pressure (APP) and pulse wave velocity (PWV) in the ascending aorta of young adults by means of velocity-encoded magnetic resonance (MR) imaging.
  88. ncbi Evaluation of an uncalibrated arterial pulse contour cardiac output monitoring system in cirrhotic patients undergoing liver surgery
    G Biancofiore
    Liver Transplant Anaesthesia and Critical Care Medicine, Azienda Ospedaliera Universitaria Pisana, Ospedale Cisanello, Pisa, Italy
    Br J Anaesth 102:47-54. 2009
    ..We have assessed the accuracy and reliability of a recently marketed self-calibrating arterial pulse contour CO monitoring system (FloTrac/Vigileo) in end-stage liver failure patients undergoing liver transplant...
  89. ncbi Multicenter evaluation of noninvasive cardiac output measurement by bioreactance technique
    Nirav Y Raval
    Atlanta Cardiology Group, 5665 Peachtree Dunwoody Road, Suite 172, Atlanta, GA 30342, USA
    J Clin Monit Comput 22:113-9. 2008
    ..We evaluated NICOM compared to thermo- dilution (TD) in several clinical settings...
  90. ncbi Isolated systolic hypertension : prognostic information provided by pulse pressure
    M J Domanski
    Clinical Trials Group, National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7936, USA
    Hypertension 34:375-80. 1999
    Increased arterial stiffness results in increased characteristic impedance of the aorta and increased pulse wave velocity, which increases systolic and pulse pressures...
  91. ncbi Relationship between ocular pulse amplitude and systemic blood pressure measurements
    Matthias C Grieshaber
    Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland
    Acta Ophthalmol 87:329-34. 2009
    This study aimed to determine whether ocular pulse amplitude (OPA) measured with dynamic contour tonometry (DCT) is related to systemic blood pressure (BP) parameters.
  92. ncbi On the effects of gating in diffusion imaging of the brain using single shot EPI
    S Skare
    Department of Clinical Neuroscience, MR Center, SE 171 76 Stockholm, Sweden
    Magn Reson Imaging 19:1125-8. 2001
    ..Six different trigger delays have been evaluated in the range 18-500 ms relative the peripheral pulse wave. Brain motion was found significant in and inferior to the corpus callosum area...
  93. ncbi Non-invasive model-based estimation of aortic pulse pressure using suprasystolic brachial pressure waveforms
    A Lowe
    Pulsecor Limited, Auckland, New Zealand
    J Biomech 42:2111-5. 2009
    ..Further research is necessary to confirm that more accurate brachial pressure measurement improves central pressure estimation...
  94. ncbi An updated clinical primer on large artery mechanics: implications of pulse waveform analysis and arterial tonometry
    Michael F O'Rourke
    St Vincent s Clinic, University of New South Wales, 438 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia
    Curr Opin Cardiol 20:275-81. 2005
    The use of pulse wave analysis with arterial tonometry has accelerated over the last year...
  95. ncbi Pulse wave velocity as endpoint in large-scale intervention trial. The Complior study. Scientific, Quality Control, Coordination and Investigation Committees of the Complior Study
    R Asmar
    L Institut CardioVasculaire, Paris, France
    J Hypertens 19:813-8. 2001
    To evaluate the ability of an antihypertensive therapy to improve arterial stiffness as assessed by aortic pulse wave velocity (PWV) in a large population of hypertensive patients.
  96. ncbi Usefulness of brachial-ankle pulse wave velocity as a predictive marker of multiple coronary artery occlusive disease in Korean type 2 diabetes patients
    Hai Jin Kim
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
    Diabetes Res Clin Pract 85:30-4. 2009
    ..The aim of this study is to evaluate the arterial stiffness in type 2 diabetes patients using brachial-ankle pulse wave velocity (baPWV), to demonstrate the correlation between arterial stiffness and multiple CAOD, and to suggest ..
  97. ncbi The clinical utility of dynamic contour tonometry and ocular pulse amplitude
    Jennifer S Weizer
    Duke University Eye Center, Durham, NC, USA
    J Glaucoma 16:700-3. 2007
    To determine if ocular pulse amplitude (OPA) as measured by dynamic contour tonometry (DCT) is related to severity of glaucoma, and if intraocular pressure (IOP) as measured by DCT is related to central corneal thickness (CCT).
  98. ncbi Brachial blood pressure but not carotid arterial waveforms predict cardiovascular events in elderly female hypertensives
    Anthony M Dart
    Baker Medical Research Institute, Melbourne, Victoria, 8008, Australia
    Hypertension 47:785-90. 2006
    ..3; 95% CI, 1.3 to 4.1 for pulse pressure > or =81 versus <81 mm Hg; P=0...
  99. ncbi Cardio-ankle vascular index and ankle pulse wave velocity as a marker of arterial fibrosis in kidney failure treated by hemodialysis
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 52:947-55. 2008
    ..This study sought to compare the strength of predictions of arterial fibrosis by using a new parameter, the cardio-ankle vascular index (CAVI), versus pulse wave velocity (PWV) in patients with kidney failure treated with hemodialysis.
  100. ncbi Age-specific relationship of aortic pulse wave velocity with left ventricular geometry and function in hypertension
    Giuseppe Schillaci
    Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia Medical School, Hospital Santa Maria della Misericordia, Piazzale Menghini, 1, IT 06129 Perugia, Italy
    Hypertension 49:317-21. 2007
    Aortic pulse wave velocity (PWV), generally considered an intrinsic marker of arterial stiffness, might depend in part on the velocity of myocardial fiber shortening, but the relation between PWV and myocardial function in humans has ..
  101. ncbi Endothelin-1 regulates arterial pulse wave velocity in vivo
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Coll Cardiol 42:1975-81. 2003
    The aim of this study was to investigate whether endothelin-1, acting locally, regulates arterial distensibility, assessed by measuring pulse-wave velocity in vivo.

Research Grants80

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  3. Iron-mediated vascular disease in sickle cell disease.
    John C Wood; Fiscal Year: 2010
    ..ornithine &citrulline, vitamin C, tetrahydrobiopterin, dihydrobiopterin,) and night time hypoxia (overnight pulse oximetry)...
  4. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    ..Protein stability will be analyzed by pulse-chase labeling using [3H]methionine followed by immunoprecipitation with -Syn antibodies...
  5. Regulation of microRNA-375 by cyclic-AMP in pancreatic beta-cells
    DAVID MATTHEW KELLER; Fiscal Year: 2010
    ..and chromatin immunoprecipitation, and one experiment will be used to test for post-transcriptional degradation, pulse-chase RNA labeling...
  6. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..that may act individually or in concert to monitor and report on a variety of baby vital signs, including ECG, pulse-ox, skin temperature, motion detection, EPG, and blood pressure...
  7. Characterizing TLR Function of Human Dendritic Cells in the Elderly
    Alexander Panda; Fiscal Year: 2012
    ..The PI will employ cell biology techniques including pulse-chase experiments, confocal microscopy and fluorescence resonance energy transfer to evaluate age-associated ..
  8. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..those with hypothalamic amenorrhea resulting from a period of increased weight lost, leptin treatment increased pulse frequency and mean levels of LH, ovarian volume, number of dominant follicles and estradiol levels...
  9. Characterization of epsilon-sarcoglycan interacting proteins in mouse brain
    Yuqing Li; Fiscal Year: 2012
    ..of loss of ?-SG on the synaptic transmission and plasticity, we will determine input output relationship, paired pulse ratio, and long-term potentiation of hippocampal CA1 Schaffer collateral pathway...
  10. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..of state-of-the-art techniques including whole-cell patch clamp, laser-scanning confocal microscopy, and UV-pulse laser flash photolysis, siRNA, and CD38 knockout mice to determine (1) the Ca2+ signals and physiological ..
  11. Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma
    Warren S Warren; Fiscal Year: 2010
    ..Such methods have been around for decades, but recent work in the PI's lab has exploited advanced femtosecond pulse shaping and pulse train modulation methods to dramatically increase the sensitivity- thus making it feasible to ..
  12. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..We will monitor hemodynamic status by tracking heart rate, mean arterial pressure, and arterial pulse pressure variation...
  13. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..BrdU pulse labeling experiments will be used to characterize the kinetics and migration patterns of activated autoreactive T ..
  14. Aldosterone, Autophagy, and Arterial Stiffness
    Jane A Leopold; Fiscal Year: 2013
    ..Increased arterial stiffness and premature wave reflections are important determinants of elevated systolic and pulse pressure and have been shown to predict cardiovascular morbidity and mortality, independent of coronary heart ..
  15. Masked Hypertension in Chronic Kidney Disease
    Rajiv Agarwal; Fiscal Year: 2013
    ..Target organ damage will be assessed using LV mass and pulse wave velocity by echocardiogram and 24 hour urine for albuminuria. Examinations will be repeated biannually...
  16. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2011
    ..Our aims are: 1A) Demonstrate ?M-level EPR signal detection (both CW and pulse methods) using paramagnetic samples (e.g...
  17. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2012
    ..Our aims are: 1A) Demonstrate ?M-level EPR signal detection (both CW and pulse methods) using paramagnetic samples (e.g...
  18. Simultaneous Insulin and Leptin Signaling in POMC Neurons Promotes Fertility and
    LATRICE DOREEN FAULKNER; Fiscal Year: 2013
    ..Collectively, these experiments will establish whether the absence of insulin and leptin signaling in POMC neurons elevates LH pulse secretion and testosterone release, thus impairing the steroidal negative feedback.
  19. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..As with adult women with PCOS, girls with HA demonstrate elevated LH pulse frequency, and some HA adolescents also have impairment of LH pulse suppression by P, suggesting that abnormal LH (..
  20. Familial and Birth Cohort Effects on the Aging Senses
    Karen J Cruickshanks; Fiscal Year: 2013
    ..and vascular measures (intima-medial thickness, blood pressure, retinal arteriolar and venular calibers, and pulse wave velocity)...
  21. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..of providing the user with control over the acoustic properties of the probe, such as, the power, frequency, pulse length, and pulse repetition frequency and can be used for animal studies...
  22. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..It is also expected that kisspeptin-induced Ca2+ mobilization will increase at puberty and that these changes will account for the pubertal increase in GnRH secretion. ..
  23. A Pilot Study of Yoga for Breathing and Quality of Life of Lung Cancer Patients
    JUDITH MARIE FOULADBAKHSH; Fiscal Year: 2013
    ..Outcome variables and related measures include: Breathing (spirometry, pulse oximetry, dyspnea, respiration rate, 6-Minute Walk test);oxygenation (pulse oximetry;heart rate);stress (Perceived ..
  24. Molecular Analysis of GnRH Action
    Mark S Roberson; Fiscal Year: 2012
    ..model provides the opportunity to examine the ERK- dependent pituitary-specific gene network that is induced by a pulse of GnRH using microarray analyses...
  25. Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 T
    Gregory Chang; Fiscal Year: 2013
    ..orthopedic issues in diagnosis and treatment);2) advanced magnetic resonance imaging (MRI) techniques (MR physics, pulse sequence design, image processing), and 3) design of patient-oriented, clinical radiology studies (biostatistics, ..
  26. Vitamin D and Vascular Function in Obese Children
    Kumaravel Rajakumar; Fiscal Year: 2013
    ..will include (1) brachial artery flow-mediated dilation (FMD) as a measure of vascular endothelial function;(2) pulse wave velocity as a measure of arterial stiffness;(3) surrogate estimates of insulin sensitivity (fasting glucose/..
  27. Conservative Versus Dialytic Management in Stage V Chronic Kidney Disease
    GLENN MATTHEW CHERTOW; Fiscal Year: 2010
    ..cognitive function, mental health, nutritional and inflammatory status, body composition, blood pressure and pulse wave velocity, hospitalization rate and number of hospital days...
  28. Mechanisms of assembly of photoreceptor G protein complexes
    Barry M Willardson; Fiscal Year: 2013
    ..these aims, a number of methods are proposed including site-directed mutagenesis and cell-based binding assays, pulse-chase assembly measurements of protein complexes, purification of large protein complexes and cryo-electron ..
  29. Biofilm matrix-degrading enzymes for the treatment and prevention of S. aureus-as
    Jeffrey B Kaplan; Fiscal Year: 2013
    ..freshly contaminated full-thickness wounds? (3) Do matrix-degrading enzymes potentiate the ability of pulse irrigation treatment to decontaminate freshly contaminated full-thickness wounds? Studies will be carried out ..
  30. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
    ..that neuroprotection is associated with increased late phase inhibition in the dentate gyrus determined by paired pulse stimulation...
  31. Hospital and Household Studies of Respiratory Cryptosporidiosis and Transmission
    Jeffrey K Griffiths; Fiscal Year: 2013
    ..The respiratory status of all children will be rigorously assessed, including pulse oximetry. Both groups will be screened for Cr...
  32. Improving ambulatory community access after paralysis
    Rudi Kobetic; Fiscal Year: 2012
    ..If meeting inclusion criteria they will undergo baseline gait evaluation and have an 8-channel implantable pulse generator (IPG) and intramuscular electrodes surgically installed to correct their gait deficit...
  33. Neuroplasticity with alcohol dependence
    Scott C Steffensen; Fiscal Year: 2013
    ..1) We will evaluate spontaneous and evoked inhibitory and excitatory synaptic transmission, paired-pulse responses, total charge transfer, AMPAR/NMDAR ratio and AMPA rectification index using patch clamp ..
  34. Calcification and Vascular Cell Differentiation
    Cecilia M Giachelli; Fiscal Year: 2013
    ..It leads to cardiac valve stenosis, increased pulse pressure, hypertension and may contribute to plaque rupture, all of which can lead to heart failure...
  35. Integrated MRI-Based Examination for Evaluation of Peripheral Arterial Disease
    Felix W Wehrli; Fiscal Year: 2010
    ..Compliance is often inferred from a measurement of pulse wave velocity (PWV), which is proportional to vessel wall stiffness, and thus is inversely related to compliance...
  36. Targeted epigenetic silencing of oncogenic Transcription Factors (PQ18)
    Pilar Blancafort; Fiscal Year: 2013
    ..We will express the 6ZF constructs using inducible vectors to "pulse" and "chase" DNAme in cell culture and breast tumor models...
  37. Vascular Structure and Function in Arteriovenous Fistula Maturation
    Jonathan Himmelfarb; Fiscal Year: 2012
    ..of brachial artery flow mediated and nitroglycerin-induced dilation, b) fingertip tonometric measurement of pulse amplitude, c) arterial pulse wave velocity as a measure of arterial stiffness, and d) forearm venous ..
  38. Identification and Characterization of Adult Salivary Gland Stem Cells
    Soosan Ghazizadeh; Fiscal Year: 2013
    ..mice with regulated expression of H2B-GFP targeted to epithelial cells in salivary glands and perform long-term pulse-chase labeling to identify slow-dividing cells...
  39. Mechanisms Underlying the Progression of Arterial Stiffness in Hypertension
    Jay D Humphrey; Fiscal Year: 2013
    ..Easily measured clinical metrics, such as pulse wave velocity, can and must play an increasingly greater role in cardiovascular risk assessment, but we must ..
  40. Mouse model for eyelid disease: Congenital blepharophimosis
    Chia Yang Liu; Fiscal Year: 2013
    ..of a novel triple transgenic mouse strain, namely Kera-rtTA/tetO-Cre/R26floxedN1-ICD (KR/TC/R26fN1- ICD), by pulse induction of doxycycline (Dox) at different developmental stages...
  41. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..flowmetry of retinal capillaries, ocular perfusion pressure calculations, refraction, Pascal applanation (ocular pulse amplitude) and medical questionnaires...
  42. Legionella pneumophila developmental cycle & virulence
    PAUL STOKES HOFFMAN; Fiscal Year: 2011
    ..with sub aims of (i) tracking morphogenesis by light and electron microscopy;(i) by reporter gene fusions;(iii) pulse chase radiolabeling and proteome profiling and (iv)to assess cyst forms for resilience to detergents, biocides, ..
  43. Validation in Baboon Model of Broadband NIR Monitoring for Neonate Gut Perfusion
    David A Benaron; Fiscal Year: 2012
    ..pre-term neonates relies on the traditional methods of monitoring such as arterial blood pressure, heart rate, pulse oximetry, urine output and evidence of metabolic acidosis...
  44. Cardiac function and PIP2
    Donald W Hilgemann; Fiscal Year: 2013
    ..NCX1 couples to MEND, new NCX1 fusion proteins have been developed for on-line monitoring of NCX1 internalization, pulse-chase tracking of NCX1, and improved analysis of NCX1 mobility...
  45. Imaging of gene delivery in the central nervous system
    Assaf A Gilad; Fiscal Year: 2010
    ..This approach is based on the chemical exchange saturation transfer (CEST) contrast mechanism. A radiofrequency pulse is applied to saturate specific amide protons, reducing the water signal...
  46. Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network
    Edward K Chien; Fiscal Year: 2013
    ..used in obstetric practice (ultrasound cervical length, fetal fibronectin, home uterine monitoring, fetal pulse oximetry)...
  47. Evaluation of an MRI Biomarker for Meniscal Repair
    Hollis G Potter; Fiscal Year: 2010
    ..First, a water-sensitive pulse sequence will be used to evaluate potential fluid imbibition into the repair site...
  48. 1st Tier Drugs+Theophylline in Pediatric Severe Asthma
    JERRY JOHN ZIMMERMAN; Fiscal Year: 2010
    ..appears to be associated with faster resolution of quantitative asthma scores, more rapid normalization of pulse oximetry saturation, and respiratory rate, and accelerated improvement in spirometry variables associated with ..
  49. Clinical Translation of Nitrite Therapy to Treat Arterial Aging in Humans
    Douglas R Seals; Fiscal Year: 2012
    ..In old C57/BL6 mice we found that 3 weeks of sodium nitrite supplementation in drinking water reduced aortic pulse wave velocity (PWV), a measure of aortic stiffness, and intrinsic carotid artery stiffness by 50-80%, and ..
  50. Low energy ventricular defibrillator
    Qun Sha; Fiscal Year: 2012
    ..defibrillation system based on the VEP concept incorporating two different engineering approaches;1) variable pulse modulation and 2) single FET power amplifier system...
  51. Development of a nanosecond pulsed electric field system to treat skin cancer
    RICHARD LEE NUCCITELLI; Fiscal Year: 2011
    ..We also developed a microprocessor-controlled pulse delivery system for easy use in the clinical trials of the PulseCure...
  52. East African Cichlids: A Natural Model for Dental Regeneration
    RYAN FREDRIC BLOOMQUIST; Fiscal Year: 2013
    ..I will then employ pulse-chase analysis to verify the location and character of putative stem cells in support of my ISH experiments...
  53. Development of an instrument to track oxygen from blood to mitochondria in vivo
    Kenneth A Schenkman; Fiscal Year: 2013
    ..Evidenced by the explosion of new pulse oximetry and near infrared spectroscopy (NIRS) devices on the market, optical spectroscopy is attractive for ..
  54. Stem/progenitor cells of the chondrocyte and osteoblast lineage in vivo
    Noriaki Ono; Fiscal Year: 2013
    ..A chondrocyte-specific pulse-chase experiment will be performed to identify slowly replicating cells based on a doxycycline-regulatable Tet-off ..
  55. Neural basis of leptin action on reproduction
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..those with hypothalamic amenorrhea resulting from a period of increased weight lost, leptin treatment increased pulse frequency and mean levels of LH, ovarian volume, number of dominant follicles and estradiol levels...
  56. Advanced technology for neural interfaces based on microstimulation
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2013
    ..In a cat model, we will evaluate the safety of 140 hours of microstimulation in the cat cochlear nucleus at a pulse rate of 500 pps, in order to determine the roles of stimulus pulse rate and stimulus charge density in stimulation-..
  57. Auditory Cortex Plasticity and Tinnitus
    Brian Allman; Fiscal Year: 2012
    ..To determine which noise-exposed rats develop chronic tinnitus, behavioral testing with a gap pre-pulse inhibition acoustic startle paradigm will be used, and the results will be correlated with the ..
  58. Investigating the role of the cell cycle protein E2F1 in HIV-induced neurotoxicit
    Jacob Zyskind; Fiscal Year: 2013
    ..Stability of cleaved E2F1 protein will be compared to stability of full length E2F1 by pulse-chase...
  59. CLINICAL TRANSLATION OF 19F MRI TO VISUALIZE CANCER IMMUNOTHERAPEUTIC CELLS
    Amy K Wesa; Fiscal Year: 2012
    ..3a) Implementation of sensitive 19F MRI/MRS methods on a 3T clinical MRI system. We will optimize pulse sequences and evaluate the minimum detectable cell numbers using phantom studies...
  60. Clinical Translation of Curcumin Therapy to Treat Arterial Aging
    Douglas R Seals; Fiscal Year: 2013
    ..Our preclinical results indicate that chow supplemented with curcumin reduces aortic pulse wave velocity (PWV), the most common and clinically important measure of large elastic artery stiffness, restores ..
  61. Placental serotonin transporter uses ERp44 and Ero1-L for maturation.
    Fusun Kilic; Fiscal Year: 2010
    ..The proposed study will utilized pulse-chase experiments and immunoprecipitation assays to monitor the biogenesis of SERT proteins in (i) JAR cells, and ..
  62. Protein intake, nutrition and cardiovascular disease in stage V CKD
    Srinivasan Beddhu; Fiscal Year: 2011
    ..Arterial stiffness (aortic pulse wave velocity) and myocardial injury (serum cardiac troponin T)...
  63. WEARABLE SENSOR FOR CONTINUOUS NONINVASIVE MONITORING OF PULSE PRESSURE
    Sridhar Madala; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Wearable Sensor for Continuous Noninvasive Monitoring of Pulse Pressure Blood pressure and pulse pressure are among the most commonly measured parameters to assess cardiovascular function...
  64. MICROVASCULAR PERMEABILITY OF THE CEREBRAL CIRCULATION
    WILLIAM MAYHAN; Fiscal Year: 1992
    ..Thus, changes in pulse pressure may modulate endothelium dependent responses of cerebral arterioles...
  65. Non-intrusive Locomotion and Gait Stability Analysis Monitoring System for the El
    Sunil Saxena; Fiscal Year: 2007
    ..form-friendly, wireless, wrist-based device that provides the following functions: (1) Body Temperature (2) Pulse Oximetry (3) Heart Rate and (4) Location Information...
  66. Brain H2D MRS: Implemation and Initial Applications
    Zhiyue Wang; Fiscal Year: 2004
    ..The specific aims are: (1) to implement 2D spin-echo double-quantum MRS pulse sequences for in vivo measurement of brain metabolites in 1...
  67. Dual-pulse electrical stimulation for gastroparesis
    Jiande Chen; Fiscal Year: 2004
    ..We, therefore, propose a novel method of GES: dual pulse GES. It uses a stimulus composed of a short pulse (or pulses) followed with a long pulse...
  68. Pulse CO-Oximeter for Multiple Hemoglobin Species
    JONAS POLOGE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Conventional pulse oximetry has significant limitations because it works on the assumption that there are only two species of hemoglobin present in arterial blood, oxygenated hemoglobin (O2Hb) and ..
  69. Dual Pulse Electrical Stimulation for Gastroparesis
    Jiande Chen; Fiscal Year: 2007
    ..A novel method of GES is proposed in this application: two-channel synchronized dual pulse GES...
  70. Mechanisms of the Relaxation Response in Elderly Hypertensives
    Jeffery A Dusek; Fiscal Year: 2010
    ..Systolic blood pressure was significantly decreased by 9.4 mmHg and pulse pressure by 7.9 mmHg...
  71. Oxide Glass Fiber Optimized for Short Pulse IR Lasers
    Danh Tran; Fiscal Year: 2006
    There is a clinical need for optimized fiber transmission of short pulse mid-IR laser radiation for surgical applications. Large potential markets such as skin resurfacing, dentistry, and ophthalmology utilize the Er:YSGG (2...
  72. Surgical Laser device development for precise or bulk ablation of urologic tissue
    Jonathon D Wells; Fiscal Year: 2010
    ..work, Lockheed Martin Aculight will develop and test a thulium fiber laser that is capable of two distinct pulse modes, including a novel short pulse mode for fast cutting and a continuous wave mode...
  73. INTRAGONADOTROPE PATHWAYS REGULATING GENE TRANSCRIPTION
    John C Marshall; Fiscal Year: 2010
    ..gonadtrope cells that mediate differential transcriptional responses to gonadotropin releasing hormone (GnRH) pulse frequency...
  74. Multi-electrode Arrays with Non-hermetic Encapsulation for Neural Prostheses
    Stuart F Cogan; Fiscal Year: 2010
    ..applicant): Neural prostheses presently in commercial use employ foil and wire electrodes connected to implantable pulse generators (IPGs) housed in hermetically sealed titanium cans...
  75. Adaptive Sensory Processing in a South American Fish
    CURTIS BELL; Fiscal Year: 2003
    ..specifically, this project is concerned with gymnotiforrn fish in which the electric organ discharge is a brief pulse of electric current...
  76. NEUROETHOLOGY OF ELECTRIC COMMUNICATION
    CARL HOPKINS; Fiscal Year: 2000
    ..signal production and evolution, and will explore the neuronal basis for electric signal recognition among pulse-type electric fish...
  77. FIBER OPTIC SENSORS BASED ON POLMER SWELLING
    RUDOLF SEITZ; Fiscal Year: 1999
    ..A pulse of light is introduced into two different lengths of optical fiber using a 2X2 fiber optic coupler...
  78. Clinical trials data collection during patient care using a novel technology solu
    GREGORY JAMES CLARY; Fiscal Year: 2010
    ..offeror propose to develop and test a novel hardware and software combination solution composed of the Livescribe Pulse Smartpen with Mi-Forms data collection software, for use in clinical data collection during patient care ..
  79. Development of a Pre-Hospital Ultra-Wide Band Radar Cardiac Function Monitor
    Gregory Walcott; Fiscal Year: 2007
    ..call for the stopping of chest compressions for the determination of the presence or absence of a carotid pulse by healthcare personnel when performing cardiopulmonary resuscitation, yet performance of pulse checks is time ..
  80. Clinical Utility of MR based Hydrodynamic Parameters in Chiari Malformation
    Francis Loth; Fiscal Year: 2010
    ..We hypothesize that hydrodynamic changes to the CSF system, specifically longitudinal impedance, pulse wave velocity, and volumetric expansion, may better reflect the underlying pathophysiology associated with CM ..