gait

Summary

Summary: Manner or style of walking.

Top Publications

  1. pmc Gait speed and survival in older adults
    Stephanie Studenski
    Department of Medicine, Division of Geratric Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 305:50-8. 2011
  2. ncbi Gait variability and fall risk in community-living older adults: a 1-year prospective study
    J M Hausdorff
    Gerontology Division, Beth Israel Deaconess Medical Center and Division on Aging, Harvard Medical School, Boston, MA 02215, USA
    Arch Phys Med Rehabil 82:1050-6. 2001
  3. ncbi Predicting the probability for falls in community-dwelling older adults using the Timed Up & Go Test
    A Shumway-Cook
    Division of Physical Therapy, University of Washington, Box 356490, Seattle, WA 98195, USA
    Phys Ther 80:896-903. 2000
  4. ncbi Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery
    J M Guralnik
    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 55:M221-31. 2000
  5. pmc Fractal dynamics in physiology: alterations with disease and aging
    Ary L Goldberger
    Cardiovascular Division and Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:2466-72. 2002
  6. ncbi Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena
    Bastiaan R Bloem
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Mov Disord 19:871-84. 2004
  7. ncbi Meaningful change and responsiveness in common physical performance measures in older adults
    Subashan Perera
    Division of Geriatric Medicine and Department of Biostatistics, Univeristy of Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Am Geriatr Soc 54:743-9. 2006
  8. pmc Gait and cognition: a complementary approach to understanding brain function and the risk of falling
    Manuel Montero-Odasso
    Division of Geriatric Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
    J Am Geriatr Soc 60:2127-36. 2012
  9. pmc Gait analysis using wearable sensors
    Weijun Tao
    School of Mechanical Engineering, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing 210094, China
    Sensors (Basel) 12:2255-83. 2012
  10. ncbi Motor patterns in human walking and running
    G Cappellini
    Department of Neuromotor Physiology, Scientific Institute Foundation Santa Lucia, 306 via Ardeatina, 00179 Rome, Italy
    J Neurophysiol 95:3426-37. 2006

Detail Information

Publications396 found, 100 shown here

  1. pmc Gait speed and survival in older adults
    Stephanie Studenski
    Department of Medicine, Division of Geratric Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 305:50-8. 2011
    ..Physical performance measures, such as gait speed, might help account for variability, allowing clinicians to make more individualized estimates.
  2. ncbi Gait variability and fall risk in community-living older adults: a 1-year prospective study
    J M Hausdorff
    Gerontology Division, Beth Israel Deaconess Medical Center and Division on Aging, Harvard Medical School, Boston, MA 02215, USA
    Arch Phys Med Rehabil 82:1050-6. 2001
    To test the hypothesis that increased gait variability predicts falls among community-living older adults attending an outpatient clinic.
  3. ncbi Predicting the probability for falls in community-dwelling older adults using the Timed Up & Go Test
    A Shumway-Cook
    Division of Physical Therapy, University of Washington, Box 356490, Seattle, WA 98195, USA
    Phys Ther 80:896-903. 2000
    ..This study examined the sensitivity and specificity of the Timed Up & Go Test (TUG) under single-task versus dual-task conditions for identifying elderly individuals who are prone to falling...
  4. ncbi Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery
    J M Guralnik
    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland 20892 9205, USA
    J Gerontol A Biol Sci Med Sci 55:M221-31. 2000
    ....
  5. pmc Fractal dynamics in physiology: alterations with disease and aging
    Ary L Goldberger
    Cardiovascular Division and Margret and H A Rey Laboratory for Nonlinear Dynamics in Medicine, Department of Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:2466-72. 2002
    ..Similar approaches show promise in assessing other regulatory systems, such as human gait control in health and disease...
  6. ncbi Falls and freezing of gait in Parkinson's disease: a review of two interconnected, episodic phenomena
    Bastiaan R Bloem
    Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Mov Disord 19:871-84. 2004
    Falls and freezing of gait are two "episodic" phenomena that are common in Parkinson's disease...
  7. ncbi Meaningful change and responsiveness in common physical performance measures in older adults
    Subashan Perera
    Division of Geriatric Medicine and Department of Biostatistics, Univeristy of Pittsburgh, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Am Geriatr Soc 54:743-9. 2006
    ..To estimate the magnitude of small meaningful and substantial individual change in physical performance measures and evaluate their responsiveness...
  8. pmc Gait and cognition: a complementary approach to understanding brain function and the risk of falling
    Manuel Montero-Odasso
    Division of Geriatric Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada
    J Am Geriatr Soc 60:2127-36. 2012
    Until recently, clinicians and researchers have performed gait assessments and cognitive assessments separately when evaluating older adults, but increasing evidence from clinical practice, epidemiological studies, and clinical trials ..
  9. pmc Gait analysis using wearable sensors
    Weijun Tao
    School of Mechanical Engineering, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing 210094, China
    Sensors (Basel) 12:2255-83. 2012
    b>Gait analysis using wearable sensors is an inexpensive, convenient, and efficient manner of providing useful information for multiple health-related applications...
  10. ncbi Motor patterns in human walking and running
    G Cappellini
    Department of Neuromotor Physiology, Scientific Institute Foundation Santa Lucia, 306 via Ardeatina, 00179 Rome, Italy
    J Neurophysiol 95:3426-37. 2006
    ..in 32 ipsilateral limb and trunk muscles during human locomotion, and compared the effects of speed (3-12 km/h) and gait. We found that the timing of muscle activation was accounted for by five basic temporal activation components ..
  11. ncbi Local dynamic stability and variability of gait are associated with fall history in elderly subjects
    Marcel J P Toebes
    MOVE Research Institute Amsterdam, Faculty of Human Movement Sciences, VU University Amsterdam, The Netherlands
    Gait Posture 36:527-31. 2012
    b>Gait parameters that can be measured with simple instrumentation may hold promise for identifying individuals at risk of falling...
  12. pmc The role of executive function and attention in gait
    Galit Yogev-Seligmann
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 23:329-42; quiz 472. 2008
    Until recently, gait was generally viewed as a largely automated motor task, requiring minimal higher-level cognitive input. Increasing evidence, however, links alterations in executive function and attention to gait disturbances...
  13. ncbi Age- and gender-related test performance in community-dwelling elderly people: Six-Minute Walk Test, Berg Balance Scale, Timed Up & Go Test, and gait speeds
    Teresa M Steffen
    Program in Physical Therapy, Concordia University Wisconsin, 12800 N Lake Shore Dr, Mequon, WI 53097, USA
    Phys Ther 82:128-37. 2002
    ..The purpose of this study was to provide data for 4 common clinical tests in a sample of community-dwelling older adults...
  14. ncbi Attention and the control of posture and gait: a review of an emerging area of research
    Marjorie Woollacott
    Department of Exercise and Movement Science, University of Oregon, Eugene, OR 97403, USA
    Gait Posture 16:1-14. 2002
    Research on the relationship between attention and the control of posture and gait is a new and expanding area with studies on young adults revealing the role of cognitive factors in the control of balance during standing and walking...
  15. ncbi Accelerometry: a technique for quantifying movement patterns during walking
    Justin J Kavanagh
    School of Physiotherapy and Exercise Science, Griffith University, Gold Coast Campus, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia
    Gait Posture 28:1-15. 2008
    ..The benefits of using accelerometers compared to more traditional gait analysis instruments include low cost; testing is not restricted to a laboratory environment; accelerometers are ..
  16. ncbi OpenSim: open-source software to create and analyze dynamic simulations of movement
    Scott L Delp
    Department of Bioengineering, Stanford University, Clark Center, Room S 170, 318 Campus Drive, Stanford, CA 94305 5450, USA
    IEEE Trans Biomed Eng 54:1940-50. 2007
    ..We are using this system to simulate the dynamics of individuals with pathological gait and to explore the biomechanical effects of treatments...
  17. ncbi Dual tasking, gait rhythmicity, and Parkinson's disease: which aspects of gait are attention demanding?
    Galit Yogev
    Movement Disorders Unit, Neurology Department, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    Eur J Neurosci 22:1248-56. 2005
    Cognitive function and the performance of a secondary, dual task may affect certain aspects of gait, but the relationships between cognitive function and gait are not well understood...
  18. ncbi Effect of cognitive remediation on gait in sedentary seniors
    Joe Verghese
    Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, 1165 Morris Park Avenue, Bronx, NY 10461, USA
    J Gerontol A Biol Sci Med Sci 65:1338-43. 2010
    Attention and executive functions show strong associations with slow gait and falls in seniors and have been shown to be amenable to cognitive remediation...
  19. ncbi Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis
    Susan W Muir
    Division of Geriatric Medicine, Department of Medicine, Parkwood Hospital, University of Western Ontario, London, Ontario, Canada
    J Am Geriatr Soc 59:2291-300. 2011
    To systematically review and quantitatively synthesize the effect of vitamin D supplementation on muscle strength, gait, and balance in older adults.
  20. pmc Executive function, memory, and gait speed decline in well-functioning older adults
    N L Watson
    Department of Epidemiology, University of Pittsburgh, Pennsylvania, Pittsburgh, PA 15213 3545, USA
    J Gerontol A Biol Sci Med Sci 65:1093-100. 2010
    In community-dwelling older adults, global cognitive function predicts longitudinal gait speed decline. Few prospective studies have evaluated whether specific executive cognitive deficits in aging may account for gait slowing over time.
  21. ncbi Brain functional activity during gait in normal subjects: a SPECT study
    H Fukuyama
    Department of Brain Pathophysiology, Faculty of Medicine, Kyoto University, Sakyo ku, Japan
    Neurosci Lett 228:183-6. 1997
    ..These results suggested that the cerebral cortices controlling motor functions, visual cortex, basal ganglia and the cerebellum might be involved in the bipedal locomotor activities in humans...
  22. pmc Interactive rhythmic auditory stimulation reinstates natural 1/f timing in gait of Parkinson's patients
    Michael J Hove
    Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology, Yokohama, Japan
    PLoS ONE 7:e32600. 2012
    Parkinson's disease (PD) and basal ganglia dysfunction impair movement timing, which leads to gait instability and falls...
  23. pmc Striding out with Parkinson disease: evidence-based physical therapy for gait disorders
    Meg E Morris
    Melbourne School of Health Sciences, The University of Melbourne, Victoria, Melbourne 3010, Australia
    Phys Ther 90:280-8. 2010
    ..This article critiques the major physical therapy approaches related to gait rehabilitation in people with PD: compensatory strategies, motor skill learning, management of secondary sequelae, ..
  24. ncbi Hip contact forces and gait patterns from routine activities
    G Bergmann
    Biomechanics Laboratory, Benjamin Frunklin School of Medicine, Free University of Berlin, Hindenburgdamm 30, 12203, Berlin, Germany
    J Biomech 34:859-71. 2001
    ..loads acting at the hip joint have so far only been measured in few patients and without detailed documentation of gait data. Such information is required to test and improve wear, strength and fixation stability of hip implants...
  25. ncbi Computer optimization of a minimal biped model discovers walking and running
    Manoj Srinivasan
    Bio robotics and Locomotion Laboratory, Theoretical and Applied Mechanics, Cornell University, 306 Kimball Hall, Ithaca, New York 14853, USA
    Nature 439:72-5. 2006
    Although people's legs are capable of a broad range of muscle-use and gait patterns, they generally prefer just two...
  26. ncbi Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force
    G Abellan Van Kan
    Gerontopole, Department of Geriatric Medicine, Toulouse University Hospital, Toulouse, France
    J Nutr Health Aging 13:881-9. 2009
    The use of a simple, safe, and easy to perform assessment tool, like gait speed, to evaluate vulnerability to adverse outcomes in community-dwelling older people is appealing, but its predictive capacity is still questioned...
  27. pmc Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study
    Julien Dumurgier
    INSERM, U708, F 75013, Paris, France
    BMJ 339:b4460. 2009
    ..To study the relation between low walking speed and the risk of death in older people, both overall and with regard to the main causes of death...
  28. ncbi Gait analysis using a shoe-integrated wireless sensor system
    Stacy J Morris Bamberg
    Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    IEEE Trans Inf Technol Biomed 12:413-23. 2008
    We describe a wireless wearable system that was developed to provide quantitative gait analysis outside the confines of the traditional motion laboratory...
  29. ncbi Symmetry and limb dominance in able-bodied gait: a review
    H Sadeghi
    Research Center, Sainte Justine Hospital, 3175 Cote Ste Catherine, Quebec, H3T 1C5, Montreal, Canada
    Gait Posture 12:34-45. 2000
    As one of the most universal of all human activities, gait in the able-bodied has received considerable attention, but many aspects still need to be clarified...
  30. ncbi An optimized Kalman filter for the estimate of trunk orientation from inertial sensors data during treadmill walking
    Claudia Mazzà
    Laboratory of Locomotor Apparatus Bioengineering, Department of Human Movement and Sport Sciences, Università degli Studi di Roma Foro Italico, Piazza Lauro de Bosis, 6, 00135 Rome, Italy
    Gait Posture 35:138-42. 2012
    ..Further studies are needed to determine the filter parameters that are most suitable for other motor tasks...
  31. ncbi Energy expenditure and biomechanical characteristics of lower limb amputee gait: the influence of prosthetic alignment and different prosthetic components
    Thomas Schmalz
    Department of Research, Otto Bock Health Care, Duderstadt, Germany
    Gait Posture 16:255-63. 2002
    ..alignments and components on oxygen consumption and the important biomechanical characteristics of the normal gait pattern of leg amputees was investigated...
  32. pmc Brain white matter lesions detected by magnetic resonance [correction of resosnance] imaging are associated with balance and gait speed
    J M Starr
    Geriatric Medicine Unit, University of Edinburgh, Royal Victoria Hospital, Craigleith Road, Edinburgh EH4 2DN, Scotland, UK
    J Neurol Neurosurg Psychiatry 74:94-8. 2003
    ..To investigate the relations between premorbid and current mental ability, mood, and white matter signal abnormalities detected by T2 weighted brain magnetic resonance imaging (MRI) and impairment of balance and mobility in older adults...
  33. pmc Dual-tasking and gait in people with mild cognitive impairment. The effect of working memory
    Manuel Montero-Odasso
    Department of Medicine, Division of Geriatric Medicine, Parkwood Hospital, The University of Western Ontario, London, ON Canada
    BMC Geriatr 9:41. 2009
    ..Studies evaluating associations between cognitive factors and gait performance in people with Mild Cognitive Impairment (MCI) are scarce...
  34. pmc Gait dynamics, fractals and falls: finding meaning in the stride-to-stride fluctuations of human walking
    Jeffrey M Hausdorff
    Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    Hum Mov Sci 26:555-89. 2007
    ..The magnitude of the stride-to-stride fluctuations and their changes over time during a walk - gait dynamics - may be useful in understanding the physiology of gait, in quantifying age-related and pathologic ..
  35. ncbi Automatic detection of gait events using kinematic data
    Ciara M O'Connor
    School of Electrical, Electronic and Mechanical Engineering, University College Dublin, Belfield, Dublin 4, Ireland
    Gait Posture 25:469-74. 2007
    ..timing of heel strike (HS) and toe off (TO), the events that mark the transitions between stance and swing phase of gait, is essential when analysing gait. Force plate recordings are routinely used to identify these events...
  36. pmc Feature extraction and selection for objective gait analysis and fall risk assessment by accelerometry
    Benoit Caby
    Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Biomed Eng Online 10:1. 2011
    ..The analysis presented in this article makes a first step in this direction providing a way to analyze gait and classify hospitalized elderly fallers and non-faller...
  37. ncbi Sensitivity of trunk variability and stability measures to balance impairments induced by galvanic vestibular stimulation during gait
    Kimberley S van Schooten
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Amsterdam, The Netherlands
    Gait Posture 33:656-60. 2011
    ..of measures of variability, local stability and orbital stability of trunk kinematics to balance impairments during gait, we used galvanic vestibular stimulation (GVS) to impair balance in 12 young adults while walking on a treadmill at ..
  38. pmc Gait mechanics influence healthy cartilage morphology and osteoarthritis of the knee
    Thomas P Andriacchi
    Department of Mechanical Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305 4038, USA
    J Bone Joint Surg Am 91:95-101. 2009
    ....
  39. ncbi Individual recognition using gait energy image
    Ju Han
    Center for Research in Intelligent Systems, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, USA
    IEEE Trans Pattern Anal Mach Intell 28:316-22. 2006
    In this paper, we propose a new spatio-temporal gait representation, called Gait Energy Image (GEI), to characterize human walking properties for individual recognition by gait...
  40. ncbi Changes in gait when anticipating slippery floors
    Rakie Cham
    Room 153, Department of Bioengineering, Eye and Ear Institute Building, University of Pittsburgh, 203 Lothrop Street, Pittsburgh, PA 15213, USA
    Gait Posture 15:159-71. 2002
    ..Thus, the goal of this study was to quantify changes in gait biomechanics when subjects anticipate slippery environments...
  41. ncbi Normal walking speed: a descriptive meta-analysis
    Richard W Bohannon
    Program in Physical Therapy, Department of Kinesiology, Neag School of Education, University of Connecticut, Storrs, CT 06268 2101, USA
    Physiotherapy 97:182-9. 2011
    ..Walking speed has implications for community functioning and is predictive of important outcomes. Determining whether an individual's walking speed is limited requires normal values for comparison...
  42. ncbi Local dynamic stability versus kinematic variability of continuous overground and treadmill walking
    J B Dingwell
    Sensory Motor Performance Program, Rehabiliation Institute of Chicago, IL 60611, USA
    J Biomech Eng 123:27-32. 2001
    ..Marimum finite-time Lyapunov exponents were estimated to quantify local dynamic stability. Local stability of gait kinematics was shown to be achieved over multiple consecutive strides...
  43. ncbi Concurrent validity of a trunk tri-axial accelerometer system for gait analysis in older adults
    Antonia Hartmann
    Institute of Human Movement Sciences and Sport, ETH Honggerberg, HIT Gebäude, Zurich, Switzerland
    Gait Posture 29:444-8. 2009
    ..validity of a trunk tri-axial accelerometer system (DynaPort) with the GAITRite system for spatio-temporal gait parameters at preferred, slow and fast self-selected walking speed that were recorded for averaged and individual ..
  44. ncbi The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis
    Thomas P Andriacchi
    Department of Mechanical Engineering, Biomechanical Engineering, Stanford University, Stanford, CA 94305, USA
    Curr Opin Rheumatol 18:514-8. 2006
    ..This review examines recent in-vivo studies of ambulation and discusses the fundamental role of mechanics of ambulation in the initiation and progression of osteoarthritis at the knee...
  45. ncbi A framework for the in vivo pathomechanics of osteoarthritis at the knee
    Thomas P Andriacchi
    Department of Mechanical Engineering, Stanford University, Division of Biomechanical Engineering, Stanford, CA 94305 4038, USA
    Ann Biomed Eng 32:447-57. 2004
    ..that is based on an analysis of studies describing assays of biomarkers, cartilage morphology, and human function (gait analysis). The framework is divided into an Initiation Phase and a Progression Phase...
  46. ncbi Improvement in usual gait speed predicts better survival in older adults
    Susan E Hardy
    Division of Geriatric Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 55:1727-34. 2007
    ..To estimate the relationship between 1-year improvement in measures of health and physical function and 8-year survival...
  47. ncbi Correlation between the knee adduction torque and medial contact force for a variety of gait patterns
    Dong Zhao
    Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA
    J Orthop Res 25:789-97. 2007
    The external knee adduction torque has been proposed as a surrogate measure for medial compartment load during gait. However, a direct link between these two quantities has not been demonstrated using in vivo measurement of medial ..
  48. ncbi Simulation of a knee joint replacement during a gait cycle using explicit finite element analysis
    A C Godest
    Bioengineering Science Research Group, School of Engineering Sciences, University of Southampton, Highfield, Southampton SO17 1BJ, UK
    J Biomech 35:267-75. 2002
    ..A simulation of a total knee joint replacement subjected to a single gait cycle within a knee wear simulator was performed and the results were compared with experimental data...
  49. ncbi Cortical mapping of gait in humans: a near-infrared spectroscopic topography study
    I Miyai
    Neurorehabilitation Research Institute, Bobath Memorial Hospital, Higashinakahama, Joto-ku, Osaka 536-0023, Japan
    Neuroimage 14:1186-92. 2001
    ..We succeeded in visualizing cortical activation patterns of human gait by measuring relative changes in local hemoglobin oxygenation using a recently developed near-infrared ..
  50. ncbi Effects of visual and auditory cues on gait initiation in people with Parkinson's disease
    Ying Jiang
    School of Rehabilitation Therapy, Queen s University, Kingston, Ontario, Canada
    Clin Rehabil 20:36-45. 2006
    To evaluate the effects of auditory and visual cues on gait initiation in people with Parkinson's disease.
  51. ncbi Reliability of the GAITRite walkway system for the quantification of temporo-spatial parameters of gait in young and older people
    Hylton B Menz
    Prince of Wales Medical Research Institute, University of New South Wales, High St, Randwick, Sydney NSW 2031, Australia
    Gait Posture 20:20-5. 2004
    ..of an instrumented walkway system (the GAITRite mat) for the measurement of temporal and spatial parameters of gait in young and older people. Thirty young subjects (12 males, 18 females) aged between 22 and 40 years (mean 28.5, S...
  52. ncbi Virtual environments for motor rehabilitation: review
    Maureen K Holden
    Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cyberpsychol Behav 8:187-211; discussion 212-9. 2005
    ....
  53. ncbi Gait-related cerebral alterations in patients with Parkinson's disease with freezing of gait
    Anke H Snijders
    Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, The Netherlands
    Brain 134:59-72. 2011
    Freezing of gait is a common, debilitating feature of Parkinson's disease. We have studied gait planning in patients with freezing of gait, using motor imagery of walking in combination with functional magnetic resonance imaging...
  54. ncbi Spatio-temporal parameters of gait measured by an ambulatory system using miniature gyroscopes
    Kamiar Aminian
    Metrology Laboratory, Swiss Federal Institute of Technology EPFL, CH 1015 Lausanne, Switzerland
    J Biomech 35:689-99. 2002
    ..This original method based on wavelet analysis is proposed to compute the values of temporal gait parameters from the angular velocity of lower limbs...
  55. pmc Muscle strength, gait, and balance in 20 patients with hip osteoarthritis followed for 2 years after THA
    Anton Rasch
    Stockholm Spine Center, Löwenströmska Hospital, Upplands Vasby, Sweden
    Acta Orthop 81:183-8. 2010
    ..Deficits in the different limb muscles and their recovery courses are largely unknown, however. We hypothesized that there is persisting muscular weakness in lower limb muscles and an impaired balance and gait 2 years after THA.
  56. ncbi Gait variability at fast-pace walking speed: a biomarker of mild cognitive impairment?
    O Beauchet
    Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France
    J Nutr Health Aging 17:235-9. 2013
    ..The interpretation of the increase in stride-to-stride variability of stride time (STV) regarding the evolution of cognitive deficits across the dementia spectrum is matter of debate...
  57. ncbi A review of analytical techniques for gait data. Part 2: neural network and wavelet methods
    T Chau
    Bloorview MacMillan Centre, 350 Rumsey Road, Toronto, Ontario, Canada M4G 1R8
    Gait Posture 13:102-20. 2001
    Multivariate gait data have traditionally been challenging to analyze. Part 1 of this review explored applications of fuzzy, multivariate statistical and fractal methods to gait data analysis...
  58. pmc Is timed up and go better than gait speed in predicting health, function, and falls in older adults?
    Laura J Viccaro
    Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 59:887-92. 2011
    To assess whether the Timed Up and Go (TUG) is superior to gait speed in predicting multiple geriatric outcomes.
  59. pmc Three dimensional gait analysis using wearable acceleration and gyro sensors based on quaternion calculations
    Shigeru Tadano
    Division of Human Mechanical Systems and Design, Faculty of Engineering, Hokkaido University, Sapporo, Japan
    Sensors (Basel) 13:9321-43. 2013
    This paper proposes a method for three dimensional gait analysis using wearable sensors and quaternion calculations. Seven sensor units consisting of a tri-axial acceleration and gyro sensors, were fixed to the lower limbs...
  60. pmc Gait control: a specific subdomain of executive function?
    Olivier Beauchet
    UPRES EA 2646, University of Angers, UNAM, France
    J Neuroeng Rehabil 9:12. 2012
    Few studies looked at the association between gait variability and executive subdomains (ESD). The aim of this study was to examine the association between ESD (i.e...
  61. ncbi Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly persons
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, NE, Seattle, WA 98115, USA
    J Gerontol A Biol Sci Med Sci 62:1244-51. 2007
    Recent evidence suggests that physical decline and slower gait may be associated with early signs of dementia, but more information on healthy older adults is needed.
  62. ncbi On-shoe wearable sensors for gait and turning assessment of patients with Parkinson's disease
    Benoit Mariani
    Laboratory of Movement Analysis and Measurement, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    IEEE Trans Biomed Eng 60:155-8. 2013
    ..on-shoe and processing algorithm, which provides outcome measures characterizing PD motor symptoms during TUG and gait tests. Our results on ten PD patients and ten age-matched elderly subjects indicate an accuracy ± precision of 2...
  63. ncbi Gait instability and fractal dynamics of older adults with a "cautious" gait: why do certain older adults walk fearfully?
    T Herman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel
    Gait Posture 21:178-85. 2005
    Many older adults walk with a cautious and impaired gait of unknown origin, however, the relationship between fear of falling and the observed gait changes is not well understood...
  64. ncbi Cortical control of gait in healthy humans: an fMRI study
    ChiHong Wang
    Department of Neurology, Cardinal Tien Hospital Yung Ho Branch, Taipei, Taiwan
    J Neural Transm 115:1149-58. 2008
    This study examined the cortical control of gait in healthy humans using functional magnetic resonance imaging (fMRI). Two block-designed fMRI sessions were conducted during motor imagery of a locomotor-related task...
  65. ncbi Is gait variability reliable in older adults and Parkinson's disease? Towards an optimal testing protocol
    Brook Galna
    Institute for Ageing and Health, Clinical Ageing Research Unit, Newcastle University, NE4 5PL, United Kingdom
    Gait Posture 37:580-5. 2013
    Despite the widespread use of gait variability in research and clinical studies, testing protocols designed to optimise its reliability have not been established...
  66. ncbi Decomposing biological motion: a framework for analysis and synthesis of human gait patterns
    Nikolaus F Troje
    Ruhr Universitat, Bochum, Germany
    J Vis 2:371-87. 2002
    ..A simple motion modeler is presented that can be used to visualize and exaggerate the differences in male and female walking patterns...
  67. ncbi The effects of arm swing on human gait stability
    Sjoerd M Bruijn
    Research Institute MOVE, Faculty of Human Movement Sciences, VU University Van der Boechorststraat 9, NL 1081 BT, Amsterdam, The Netherlands
    J Exp Biol 213:3945-52. 2010
    Arm swing during human gait has been shown to reduce both angular momentum about the vertical and energy expenditure, and has been hypothesized to enhance gait stability...
  68. ncbi Gait and cognition: the relationship between gait stability and variability with executive function in persons with and without dementia
    Trienke Ijmker
    Center for Human Movement Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Gait Posture 35:126-30. 2012
    Besides cognitive decline, dementia is characterized by gait changes and increased fall risk, also in early stages of the disease...
  69. pmc Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis
    T Miyazaki
    Department of Orthopaedic Surgery, Fukui Medical University, Japan
    Ann Rheum Dis 61:617-22. 2002
    ..To test the hypothesis that dynamic load at baseline can predict radiographic disease progression in patients with medial compartment knee osteoarthritis (OA)...
  70. pmc Dynamic principles of gait and their clinical implications
    Arthur D Kuo
    Departments of Mechanical Engineering and Biomedical Engineering, University of Michigan, 2350 Hayward St, Ann Arbor, MI 48109 2125, USA
    Phys Ther 90:157-74. 2010
    A healthy gait pattern depends on an array of biomechanical features, orchestrated by the central nervous system for economy and stability...
  71. ncbi Functional electrical stimulation to dorsiflexors and plantar flexors during gait to improve walking in adults with chronic hemiplegia
    David G Embrey
    Good Samaritan Physical Medicine and Rehabilitation Center, Puyallup, WA 98372, USA
    Arch Phys Med Rehabil 91:687-96. 2010
    To determine whether functional electrical stimulation (FES) timed to activate the dorsiflexors and plantar flexors during gait improves the walking of adults with hemiplegia.
  72. pmc Functional gait assessment and balance evaluation system test: reliability, validity, sensitivity, and specificity for identifying individuals with Parkinson disease who fall
    Abigail L Leddy
    Washington University School of Medicine, St Louis, Missouri, USA
    Phys Ther 91:102-13. 2011
    b>Gait impairments, balance impairments, and falls are prevalent in individuals with Parkinson disease (PD)...
  73. ncbi Ambulatory estimation of foot placement during walking using inertial sensors
    H Martin Schepers
    Institute for Biomedical Technology and Technical Medicine MIRA, University of Twente, AE Enschede, The Netherlands
    J Biomech 43:3138-43. 2010
    ..It is concluded that the ambulatory measurement system was able to reliably estimate foot placement during walking...
  74. pmc Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease
    Carine Karachi
    Universite Pierre et Marie Curie Paris 6, CR Icm, UMR S975, Paris, France
    J Clin Invest 120:2745-54. 2010
    b>Gait disorders and postural instability, which are commonly observed in elderly patients with Parkinson disease (PD), respond poorly to dopaminergic agents used to treat other parkinsonian symptoms...
  75. ncbi Locomotor training improves daily stepping activity and gait efficiency in individuals poststroke who have reached a "plateau" in recovery
    Jennifer L Moore
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, IL, USA
    Stroke 41:129-35. 2010
    ....
  76. ncbi Control of foot trajectory in human locomotion: role of ground contact forces in simulated reduced gravity
    Y P Ivanenko
    Sezione di Fisiologia Umana, Istituto Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
    J Neurophysiol 87:3070-89. 2002
    ..The results did not depend on the specific instruction given to the subject. Therefore we conclude that minimal contact forces are sufficient for accurate foot trajectory control...
  77. ncbi Concurrent related validity of the GAITRite walkway system for quantification of the spatial and temporal parameters of gait
    Belinda Bilney
    School of Physiotherapy, La Trobe University, Bundoora, VIC 3083, Australia
    Gait Posture 17:68-74. 2003
    The GAITRite is a portable gait analysis tool for automated measurement of spatiotemporal gait parameters...
  78. ncbi Significance of load receptor input during locomotion: a review
    V Dietz
    Swiss Paraplegic Centre, University Hospital Balgrist, Forchstr 340, CH 8008, Zurich, Switzerland
    Gait Posture 11:102-10. 2000
    A basic aspect of the neuronal control of quadrupedal locomotion of cat and of bipedal stance and gait of humans concerns the antigravity function of leg extensors...
  79. ncbi Gait and balance impairment in early multiple sclerosis in the absence of clinical disability
    C L Martin
    School of Physiotherapy, The University of Melbourne, Melbourne 3010, Australia
    Mult Scler 12:620-8. 2006
    This study evaluated the gait and balance performance of two clinically distinct groups of recently diagnosed and minimally impaired multiple sclerosis (MS) patients (Expanded Disability Status Scale range 0-2...
  80. ncbi Gait freezing in Parkinson's disease and the stride length sequence effect interaction
    Rachel Chee
    School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria, Australia
    Brain 132:2151-60. 2009
    Freezing of gait (FOG) has been identified as one of the main contributors to gait disturbances in Parkinson's disease...
  81. ncbi Modular control of limb movements during human locomotion
    Yuri P Ivanenko
    Department of Neuromotor Physiology, Santa Lucia Foundation, 00179 Rome, Italy
    J Neurosci 27:11149-61. 2007
    ..found little difference among covariance planes that depended on speed, but there were differences that depended on gait. In each case, we could fit the planar trajectories with a weighted sum of the limb length and orientation ..
  82. ncbi The energy expenditure of normal and pathologic gait
    R L Waters
    Rancho Los Amigos Medical Center, 7601 E Imperial Highway, Downey, CA 90242, USA
    Gait Posture 9:207-31. 1999
    ..expenditure measurement has proven to be a reliable method of quantitatively assessing the penalties imposed by gait disability...
  83. ncbi Prospective, blinded, randomized crossover study of gait rehabilitation in stroke patients using the Lokomat gait orthosis
    Andreas Mayr
    Department of Neurology, Hospital Hochzirl, Zirl, Austria
    Neurorehabil Neural Repair 21:307-14. 2007
    Treadmill training with partial body weight support has been suggested as a useful strategy for gait rehabilitation after stroke...
  84. ncbi Estimation of gait cycle characteristics by trunk accelerometry
    Rolf Moe-Nilssen
    The Balance and Gait Unit, Section of Physiotherapy Science, Institute of Public Health and Primary Health Care, University of Bergen, Ulriksdal 8c, N 5009 Bergen, Norway
    J Biomech 37:121-6. 2004
    This study reports on the novel use of a portable system to measure gait cycle parameters. Measurements were made by a triaxial accelerometer over the lower trunk during timed walking over a range of self-administered speeds...
  85. ncbi The effects of balance training and high-intensity resistance training on persons with idiopathic Parkinson's disease
    Mark A Hirsch
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University Medical Center, Baltimore, MD, USA
    Arch Phys Med Rehabil 84:1109-17. 2003
    ..To assess immediate and near-term effects of 2 exercise training programs for persons with idiopathic Parkinson's disease (IPD)...
  86. ncbi Medical treatment of freezing of gait
    Nir Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 23:S482-8. 2008
    Freezing of gait (FOG) is frequently considered as one of the dopamine-resistant motor symptoms of Parkinsonism. Recent studies have clearly demonstrated that the Off-related FOG is improved by levodopa (L-dopa) or entacapone treatment...
  87. ncbi Gait, gait variability and the risk of multiple incident falls in older people: a population-based study
    Michele L Callisaya
    Department of Medicine, Monash Medical Centre, Monash University, Clayton, Vic, Australia
    Age Ageing 40:481-7. 2011
    it is uncertain as to which measures of gait best predict those who are likely to fall. Our aim was to investigate the associations of gait and gait variability measures with incident falls risk.
  88. pmc Associations between physical performance and executive function in older adults with mild cognitive impairment: gait speed and the timed "up & go" test
    Ellen L McGough
    Department of Rehabilitation Medicine, University of Washington, 1959 NE Pacific St, Box 356490, Seattle, WA 98195, USA
    Phys Ther 91:1198-207. 2011
    ..Physical performance decline on gait and mobility tasks in conjunction with executive dysfunction has implications for accelerated functional decline, ..
  89. ncbi Cueing for freezing of gait in patients with Parkinson's disease: a rehabilitation perspective
    Alice Nieuwboer
    Department of Rehabilitation Sciences, Katholieke Universiteit, Leuven, Belgium
    Mov Disord 23:S475-81. 2008
    Freezing of gait (FOG) has been known to respond favorably to sensory tricks and cues. However, FOG is a complex phenomenon with various motor control deficits at play...
  90. ncbi Secondary gait changes in patients with medial compartment knee osteoarthritis: increased load at the ankle, knee, and hip during walking
    Annegret Mundermann
    Stanford University Medical Center, Stanford, California 94305 4038, USA
    Arthritis Rheum 52:2835-44. 2005
    This study tested the hypothesis that gait changes related to knee osteoarthritis (OA) of varied severity are associated with increased loads at the ankle, knee, and hip.
  91. ncbi Effect of simultaneous botulinum toxin injections into several muscles on impairment, activity, participation, and quality of life among stroke patients presenting with a stiff knee gait
    Gilles D Caty
    Physical Medicine and Rehabilitation Department, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Stroke 39:2803-8. 2008
    ..purpose was to study the effect of Botulinum toxin type A (BoNT A) injections in several spastic muscles on the impairment, activity, participation, and quality of life of patients with chronic stroke presenting with a stiff knee gait.
  92. pmc Normative spatiotemporal gait parameters in older adults
    John H Hollman
    Department of Physical Medicine and Rehabilitation, Program in Physical Therapy, College of Medicine, Mayo Clinic, Rochester, MN, United States
    Gait Posture 34:111-8. 2011
    While factor analyses have characterized pace, rhythm and variability as factors that explain variance in gait performance in older adults, comprehensive analyses incorporating many gait parameters have not been undertaken and normative ..
  93. pmc The gait and balance of patients with diabetes can be improved: a randomised controlled trial
    L Allet
    Department of Epidemiology, Maastricht University and Caphri Research School, Maastricht, The Netherlands
    Diabetologia 53:458-66. 2010
    b>Gait characteristics and balance are altered in diabetic patients. Little is known about possible treatment strategies. This study evaluates the effect of a specific training programme on gait and balance of diabetic patients.
  94. pmc Automated quantitative gait analysis in animal models of movement disorders
    Caroline Vandeputte
    Laboratory for Neurobiology and Gene Therapy, Molecular Medicine, K U Leuven, Belgium
    BMC Neurosci 11:92. 2010
    ..In this study we investigated for the first time gait parameters of rat models for Parkinson's disease (PD), Huntington's disease (HD) and stroke using the Catwalk ..
  95. pmc Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegans
    Christopher Fang-Yen
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:20323-8. 2010
    To navigate different environments, an animal must be able to adapt its locomotory gait to its physical surroundings...
  96. ncbi The effect of a training program combined with augmented afferent feedback from the feet using shoe insoles on gait performance and muscle power in older adults: a randomised controlled trial
    Antonia Hartmann
    Institute of Human Movement Sciences and Sport, ETH, Zurich, Switzerland
    Disabil Rehabil 32:755-64. 2010
    Aged-related loss of afferent feedback of the feet plays an important role in gait performance...
  97. ncbi Freezing of gait in Parkinson's disease: the impact of dual-tasking and turning
    Joke Spildooren
    Department of Rehabilitation Sciences, Katholieke Universiteit, Leuven, Belgium
    Mov Disord 25:2563-70. 2010
    Turning is the most important trigger for freezing of gait (FOG) in Parkinson's disease (PD), and dual-tasking has been suggested to influence FOG as well.
  98. ncbi Methods for gait event detection and analysis in ambulatory systems
    Jan Rueterbories
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, 9220 Aalborg, Denmark
    Med Eng Phys 32:545-52. 2010
    ..For all supporting stimulation devices, it is vital to adequately detect the gait events, which is traditionally obtained by a foot switch placed under the heel...
  99. pmc Kinematic variability, fractal dynamics and local dynamic stability of treadmill walking
    Philippe Terrier
    IRR, Institut de Recherche en Réadaptation, Sion, Switzerland
    J Neuroeng Rehabil 8:12. 2011
    ..Classical (Standard Deviation, SD) and non-linear (fractal dynamics, local dynamic stability) methods were used. In addition, the correlations between the different variability indexes were analyzed...
  100. pmc Correlation between single limb support phase and self-evaluation questionnaires in knee osteoarthritis populations
    Ronen Debi
    Department of Orthopedic Surgery, Assaf Harofeh Medical Center, Zerifin, Israel
    Disabil Rehabil 33:1103-9. 2011
    To investigate the correlation between single limb support (SLS) phase (% of gait cycle) and the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) questionnaire and Medical Outcomes Study 36-Item Short-Form Health ..
  101. pmc Kinematic measures for assessing gait stability in elderly individuals: a systematic review
    D Hamacher
    Julius Wolff Institute, Charite Universitatsmedizin Berlin, Center for Sports Science and Sports Medicine Berlin, Germany
    J R Soc Interface 8:1682-98. 2011
    ..b>Gait instability is a major fall risk factor, particularly in geriatric patients, and walking is one of the most ..

Research Grants84

  1. Non-intrusive Locomotion and Gait Stability Analysis Monitoring System for the El
    Sunil Saxena; Fiscal Year: 2007
    ..The system will also have algorithms to identify certain disease conditions that produce characteristic gait abnormalities such as Parkinson's disease...
  2. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..and the phenotypes of the cells producing the bioluminescence signal;and, 3) functional assays to measure animal gait and mobility and muscle contractile force. We will try two temporal profiles for each regulator...
  3. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..Among the symptoms of CMT are foot-drop, steppage gait, high arches, foot bone abnormalities, and basic problems with hand function, as well as sometimes breathing ..
  4. Fall risk assessment and prevention in elderly with diabetes using wearable techn
    Bor Rong Chen; Fiscal Year: 2012
    ..to provide real time information about a subject's postural stability and motor adaptation ability during gait in a virtual environment...
  5. Development of a Wearable Passive Vibration Therapy System for the Lower Extremit
    JEFFREY MICHAEL LEISMER; Fiscal Year: 2010
    ..period to evaluate their effectiveness at improving functional strength measures, correlates to falls risk (gait speed and balance), and bone metabolism in older adults residing within a nursing home...
  6. Foot Bone Motion in End Stage Ankle Arthritis Patients
    William R Ledoux; Fiscal Year: 2012
    ..midtarsal and tarsometatarsal) being stretched into increased dorsiflexion during the push off phase of the gait cycle...
  7. Optimization of HDAC6 Inhibitors in the Treatment of CMT
    Ludo Van Den Bosch; Fiscal Year: 2013
    ..includes weakness of the foot and lower leg muscles, which may result in foot drop and a high-stepped gait with frequent tripping or falls...
  8. Improving ambulatory community access after paralysis
    Rudi Kobetic; Fiscal Year: 2012
    ..feasibility study of safety and effectiveness of an implanted multichannel functional electrical stimulation (FES) gait system is to correct gait instability and increase walking speed to improve ambulatory community access of persons ..
  9. Connective tissue and nervous system mechanisms of CAM therapies for low back pai
    Helene M Langevin; Fiscal Year: 2013
    ..All pigs will undergo weekly ultrasound and gait analysis using wireless orientation sensors (Aim 1)...
  10. A Phase II Trial of Levodopa in Angelman Syndrome
    Wen Hann Tan; Fiscal Year: 2013
    ..AS is characterized by mental retardation, limited speech, seizures, abnormal movements such as tremors, and ataxic gait. Currently, there is no cure for AS and treatment is largely supportive...
  11. Novel mouse models of inflammation-resolution
    Paul L Fox; Fiscal Year: 2010
    ..a classic activator of monocyte/macrophages, induces assembly of the IFN-Gamma-Activated Inhibitor of Translation (GAIT) complex that binds a specific RNA element in the 3'untranslated region (UTR) of target mRNAs, e.g...
  12. Study of Energy and Aging
    Steven Cummings; Fiscal Year: 2009
    ..Loss of mobility characterized by slowing gait speed, exertional fatigue and exhaustion is a hallmark of age-related functional decline...
  13. Vestibular rehabilitation and dizziness in geriatric patients
    Courtney Hall; Fiscal Year: 2012
    ..will be retained after discharge as measured by visual analog scale, balance-related confidence scale, dynamic gait index, and gait speed, and that retention of improvements will be correlated with home exercise compliance...
  14. MECHANICAL STIMULATION OF IVD CELLS
    Lori A Setton; Fiscal Year: 2013
    ..of autologous nucleus pulposus at the lumbar dorsal root ganglion, rats develop mechanical allodynia and abnormal gait. Here, rats will be evaluated for parameters of gait, allodynia, and thermal hyperalgesia prior to and after ..
  15. Effect of Articular Neurotoxin on Joint Pain and Neurochemical Signature
    Maren Lawson Mahowald; Fiscal Year: 2012
    ..as induced behaviors such as vocalizations, biting and fighting the handler when pressing on the painful joint and gait abnormalities due to pain using a visual video gait analysis scoring system...
  16. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2013
    ..The biomechanics of locomotion are better defined in cats and cats have a hindlimb gait that is close to human than is the rat...
  17. Biopsychosocial approaches to healthy aging
    Terrie Vasilopoulos; Fiscal Year: 2012
    ..My proposed project will focus on measures of grip strength, pulmonary function, body mass index, gait, blood pressure, and medication use as indices of physical function, and on self-reports of coping, self-esteem, ..
  18. Robotic Interventions to Enhance Locomotor Stability Following Spinal Cord Injury
    KEITH EDWARD GORDON; Fiscal Year: 2012
    ..Dr. Gordon has significant research experience in gait rehabilitation of SCI...
  19. Effects of Non-Exercise Activity on Cognitive Function in the Elderly
    Teresa J Buracchio; Fiscal Year: 2011
    ..Methods: Physical activity measures (e.g., gait speed, walks per day, total activity, and others) will be compared between cognitively intact subjects and those ..
  20. Trajectories and Markers of Neurodegeneration in Fragile X Premutation Carriers
    Susan M Rivera; Fiscal Year: 2013
    ..fragile X-associated tremor ataxia syndrome (FXTAS), characterized by neurological manifestations of progressive gait ataxia, intention tremor, Parkinsonism, dementia, autonomic dysfunction, and peripheral neuropathy...
  21. Comparative Effectiveness of Customary Fit and Strong! vs. Fit and Strong! Plus
    Susan L Hughes; Fiscal Year: 2013
    ..on physical activity maintenance at 18 months accompanied by improved LE stiffness, pain, function, strength, and gait speed as well as reduced anxiety and depression (Hughes et al., 2010)...
  22. Human iPSC neuronal models for early and late phases of FXTAS neurodegeneration
    Paul J Hagerman; Fiscal Year: 2010
    ..FXTAS involves both progressive motor dysfunction (tremor, gait ataxia, parkinsonism) and cognitive impairment/dementia...
  23. Determinants of Quality of Life in Elderly Adults with Diabetes
    Neda Laiteerapong; Fiscal Year: 2011
    ..example, both foot ulcers and falls likely contribute to a worse quality of life;however, foot ulcers may lead to gait instability and a fall, which would lead to lower quality of life...
  24. Effect of White Matter Disease on Gait and Balance in Cerebral Amyloid Angiopathy
    Anand Viswanathan; Fiscal Year: 2013
    ..1) extent of white matter disease (as measured by WMH volume and mean DTI measures) in CAA is associated with gait and balance dysfunction, cognitive impairment and disability, (2) the anatomic location of white matter disease (..
  25. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    ..Pain, paresthesiae and gait disability characterize the clinical features arising from human immunodeficiency virus (HIV)-induced distal ..
  26. Broadly Neuroprotective Drug for TBI
    Fernando Gomez Pinilla; Fiscal Year: 2010
    ..These data are very exciting and relevant to help understanding gait dysfunction common in TBI patients, and offering the possibility for developing a therapy...
  27. CRCNS: Propagation of beta oscillations in cortico-basal ganglia-thalamic loop
    Michelle M McCarthy; Fiscal Year: 2013
    ..a chronic, disabling neurologic disorder causing resting tremor, muscular rigidity, bradykinesia and impairment of gait. It is estimated that 5 million people worldwide have Parkinson's disease, and this number is projected to ..
  28. Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes
    Joseph T Hanlon; Fiscal Year: 2012
    ..defined by four alternative approaches above) and mobility problems (Short Physical Performance Battery [SPPB], and gait speed), and cognitive function decline (as measured by the Modified Mini-Mental State Examination [3MS] and the ..
  29. Effect of Prosthetic Foot-Ankle Stiffness on Amputee Function
    GLENN KLUTE; Fiscal Year: 2011
    ..Clinicians are well aware that foot stiffness strongly influences the mechanics of amputee gait and prescribe ESAR feet with manufacturer-identified stiffness levels based on body weight and self-reported ..
  30. Development of a Low Cost, Real-time Biofeedback Gait Retraining System
    SAUNDERS WHITTLESEY; Fiscal Year: 2012
    ..provided by applicant): This SBIR project is designed to enable the migration of very effective real-time gait biofeedback technology into rehabilitation clinics, hospitals, and other organizations working with impairments or ..
  31. Adult Neurological Phenotypes of Fragile X Gray Zone Expansion
    Deborah A Hall; Fiscal Year: 2013
    ..with intellectual disability, autism, infertility, an neurodegenerative disorder in adults, to include tremor and gait ataxia...
  32. STIMULATION-AUGMENTED EXERCISE AND NEUROMOTOR THERAPY
    Eric C Hartman; Fiscal Year: 2010
    ..Outcome measures will include assessment of functional improvements (i.e., FIM, gait analysis) and a dynamometer test to assess improvements in volitional control independent of exercise-related ..
  33. Pathogenic Mechanisms in Fragile X Tremor Ataxia Syndrome
    Peter K Todd; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Fragile X Tremor Ataxia Syndrome (FXTAS) is a common erited cause of gait disorder and tremor affecting upwards of 1:800 males...
  34. Phenotyping pain in a mouse model of pancreatic cancer
    Brian M Davis; Fiscal Year: 2012
    ..conduct longitudinal studies of behaviors that should be affected by ongoing pain, including open field behavior, gait analysis, and hunching, as well as testing for the development of referred hypersensitivity (e.g...
  35. Activity and Exercise Monitoring System (AEMS)
    MARK A FAUCI; Fiscal Year: 2012
    ..improve measures of mobility and fitness in older adults, particularly strength, aerobic capacity, improvements in gait and balance, as well as other long-term functional benefits such as decreased pain symptoms for those elderly with ..
  36. Biomechanics and Inflammation in Osteoarthritis
    Farshid Guilak; Fiscal Year: 2012
    ..Outcome measures include gross and histological joint appearances, synovial fluid biomarkers, and measures of gait and pain perception...
  37. Retraining Spinal Circuits With Robot-Assisted Functional Electrical Stimulation
    Deborah Won; Fiscal Year: 2013
    ..timing usually based on the onset of a detected event, such as heel strike, and typically results in abnormal gait patterns and quick onset of fatigue...
  38. The role of CCR5 in HIV-1 Tat and morphine-mediated neurodegeneration.
    Elizabeth M Podhaizer; Fiscal Year: 2013
    ..Golgi-Kopsch impregnation, microscopy, and behavioral assessments of rotarod performance, grip strength, and gait analysis to determine if CCR5 is a good therapeutic candidate to alleviate the consequences of opioid drug abuse ..
  39. PHASE-BASED CONTROL OF LOCOMOTION FOR HIGH-PERFORMANCE PROSTHESES AND ORTHOSES
    Robert D Gregg; Fiscal Year: 2013
    ..Current powered legs independently control different joints and time periods of the gait cycle, limiting robustness to environmental uncertainty and requiring clinicians to spend significant amounts of ..
  40. Identification of Responders to the FES Interventions in Stroke Population
    Rakesh Pilkar; Fiscal Year: 2013
    ..In order to comprehensively understand the effect of electrical stimulations on gait recovery, it is critical to analyze the dynamic aspects of gait and measure gait variability during the functional ..
  41. Neuronal Dysfunction in Fragile X Tremor Ataxia Syndrome
    Peter K Todd; Fiscal Year: 2013
    ..Tremor Ataxia Syndrome (FXTAS) is a common inherited neurodegenerative disorder characterized by dementia, gait disorder and tremor...
  42. Genetic analysis of a spontaneous mutation in a rat with a novel hind limb defect
    Debasish Sinha; Fiscal Year: 2010
    ..Because of this unusual appearance and gait anomaly, we have named the mutant strain frogleg...
  43. Changing a reflex to improve locomotion
    Aiko Thompson; Fiscal Year: 2013
    ..from standing to walking, and during walking reflexes are further modulated between different phases of the gait cycle...
  44. Aging the Central Nervous System and Mobility in Older Adults
    Stephanie A Studenski; Fiscal Year: 2013
    ..b>Gait and balance problems in older adults are common and severely disabling, and impose pressing clinical challenges ..
  45. Molecular genetics of Pelizaeus-Merzbacher disease
    Grace M Hobson; Fiscal Year: 2013
    ..have a similar phenotype with onset of nystagmus and hypotonia in the first months of life, and limb and gait ataxia, spastic quadriparesis, and cognitive and visual impairment during the first decade...
  46. Risk Factors for Osteoporosis in Children &Adolescents with Myelomeningocele
    Tishya A L Wren; Fiscal Year: 2013
    ..acquisition and the development of osteoporosis, including level of neurological involvement, ambulatory status, gait characteristics, and amount of walking (steps per day), and (3) to explore whether maintaining ambulation (upright ..
  47. Imaging NFkB Activity in Relation to Animal Behavior in Peripheral Neuropathy
    ROBERT D BOWLES; Fiscal Year: 2013
    ..g., gait), pain-related behaviors (mechanical and thermal hypersensitivity, running wheel activity), and characterization of ..
  48. Developing a brain-machine interface for an ankle robot
    Larry Forrester; Fiscal Year: 2012
    ..we have developed an impedance controlled ankle robot (anklebot) to enhance paretic ankle motor control and gait function in stroke survivors...
  49. Pontine motor circuits
    Jun Lu; Fiscal Year: 2013
    ..Parkinsonism includes resting tremor, rigidity, postural abnormalities, gait disturbances and bradykinesia/akinesia...
  50. A Virtually Supervised Web-Based Home Exercise Technology for Older Adults
    Bijan Najafi; Fiscal Year: 2013
    ..randomized controlled trial) we will evaluate the effectiveness of the proposed technology for improving mobility, gait, balance, quality of life, and risk of falling compared to unsupervised home trainin...
  51. Resilience to Mobility Impairment: Neural Correlates and Protective Factors
    Caterina Rosano; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Slowing gait and difficulty walking are major and common problems of older adults, they worsen with age and they are associated with greater risk of disability, hospitalization and death...
  52. Identification of Persistent Impairments in Postural Control Following Concussion
    GEORGE W SHAVER; Fiscal Year: 2011
    ..Biomechanical assessment of gait initiation (GI), gait, and gait termination (GT) provides an objective method of identifying postural instabilities ..
  53. Combined Cognitive and Gait Training
    Janis J Daly; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Combined Cognitive and Gait Training Problem: Recent research in gait training for chronic stroke survivors showed that gait coordination can be best restored using the following interventions ..
  54. Post-Stroke Contributors to Increased Energetic Cost and Decreased Gait Stability
    JESSE CRAIG DEAN; Fiscal Year: 2012
    ..One potential cause of reduced mobility is decreased gait stability, as evidenced by the increased risk of falls after a stroke...
  55. Translational Silencing in Monocytes: Role of L13a
    Barsanjit Mazumder; Fiscal Year: 2013
    ..protein L13a and its release from 60S ribosome in the formation of IFN- Gamma-Activated Inhibitor of Translation (GAIT) complex...
  56. A protein-directed RNA switch that regulates translation
    Paul L Fox; Fiscal Year: 2013
    ..cell stimulation by IFN-[unreadable], phosphorylation of Glu-Pro tRNA synthetase (EPRS) initiates formation of the GAIT (IFN-Gamma-Activated Inhibitor of Translation) complex...
  57. Function and Behavior Phenotype of Inflammatory Arthritis in the Rat Knee and TMJ
    Kyle D Allen; Fiscal Year: 2013
    ..investigated the local regulation of disease factors associated with knee arthritis and developed new quantitative gait measures of knee dysfunction for the rat pre-clinical model...
  58. Foot Prosthesis Using Tensegrity Design Principles
    JEROME RIFKIN; Fiscal Year: 2010
    ..Human testing will include instrumented gait lab testing and metabolic efficiency/oxygen consumption testing...
  59. VETerans with Stroke Translating Exercise Programs (VET STEP)
    Marianne Shaughnessy; Fiscal Year: 2013
    ..that HI-TM will establish a baseline level of cardiovascular fitness and endurance such that that the balance and gait training in LILI can be optimally applied for the greatest benefit in months 6 through 12...
  60. Using Intraoperative Measurements to Predict Postoperative Outcomes of TKA
    ROBERT ANTHONY SISTON; Fiscal Year: 2013
    ..functional challenges that are not seen in aged-matched controls, such as climbing stairs more slowly, stiff-knee gait, quadriceps weakness, and abnormal knee kinematics...
  61. Assessment and evaluation of Hill-type muscle models for predicting in vivo force
    Andrew A Biewener; Fiscal Year: 2011
    ..to simulate and evaluate motor performance to address a broad range of clinical problems and therapies that include gait rehabilitation, the evaluation and treatment of stroke, wheel chair use, and prosthetics...
  62. Functional Electrical Stimulation Mediated Neuroplasticity
    Lynne R Sheffler; Fiscal Year: 2013
    ..ankle dorsiflexion characterized by dragging of the foot during walking, which results in an inefficient and unsafe gait pattern...
  63. Functions and connections of inhibitory reticulospinal locomotor systems
    VERONIQUE VAN DER HORST; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Gait disorders are a common problem in the aging population. Etiologies include neurological problems from neuropathies to neurodegenerative disorders, to strokes that affect locomotor circuitries...
  64. ZeroG: Dynamic Over-Ground Body-Weight Support System
    Joseph Hidler; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Successfully delivering intensive yet safe gait therapy to individuals with significant walking deficits presents the greatest challenges to even the most skilled therapists...
  65. Adaptive High Intensity Electrical Stimulation for Post-Surgical Rehabilitation
    Eric Hartman; Fiscal Year: 2009
    ..following post-surgical knee immobilization is a significant therapeutic aim which is associated with quality of gait and the ability to perform activities of daily living...
  66. OUTCOMES OF HEEL CORD LENGTHENING IN CHILDREN WITH CP
    Jack Engsberg; Fiscal Year: 1999
    ..Functional measures will include: (1) oxygen uptake during gait, (2) specific gait variables, 93) Gross Motor Function Measure (GMFM) and (4) a disability questionnaire...
  67. IMPROVING GAIT AND FUNCTION IN CP BY STRENGTHENING THE ANKLE
    Jack Engsberg; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Many treatments exist to improve the gait and function of persons with cerebral palsy (CP)...
  68. Cues from touch to aid posture and gait in individuals with Parkinson's disease
    Ely Rabin; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Parkinson's disease (PD) affects the control of posture and gait, and leads to falling which contributes to reduced activity, reduced quality of life, depression, social isolation and mortality...
  69. EXERCISE--NURSING INTERVENTION FOR FUNCTIONAL RECOVERY
    Beverly Roberts; Fiscal Year: 2000
    ..functional decline characterized by increasing dependence in activities of daily living (ADL) and abnormalities in gait. Although the positive effects on functional recovery is widely accepted, exercise, as a nursing intervention, has ..
  70. Applications of FES Artificial Walking for Cerebral Palsy
    Jessica Rose; Fiscal Year: 2009
    ..together experts in FES artificial walking, neuromuscular physiology, computer science, biomechanical modeling and gait analysis to advance FES assisted walking for children with CP and to plan a multi-centered clinical trial using ..
  71. GLYCOSYLTRANSFERASE FUNCTION DURING FERTILIZATION
    BARRY SHUR; Fiscal Year: 2006
    ..and molecular approaches to characterize an unusual sperm surface receptor (Beta-1,4-galactosyltransferase I, GaIT) for glycoside ligands in the egg zona pellucida...
  72. Influence of Ankle Motion on Bilateral Amputee Gait
    Steven Gard; Fiscal Year: 2004
    We propose to investigate the effect of prosthetic ankle motion on the mechanics of bilateral lower-limb amputee gait. Bilateral lower-limb amputees often walk with rigid or stiff legs, which may be due in part to insufficient compliance ..
  73. Enabling ACL Repair Using Proprietary Collagen Device
    Emma Wright; Fiscal Year: 2009
    ..This model will allow evaluation for development of osteoarthritis (OA), validated gait/lameness scores, arthroscopic inspection of the knee, comparison of biomechanical results and histology to known ..
  74. Symmetrical walking enhanced neuroplasticity post-stroke
    JAMES STINEAR; Fiscal Year: 2009
    ..Chronic subcortical stroke subjects will be recruited who have a moderate degree of asymmetry in their gait variables...
  75. DBS of the pedunculopontine nucleus in Parkinsonian primate
    Jerrold L Vitek; Fiscal Year: 2010
    ..producing substantial improvements in tremor, bradykinesia, and rigidity, but has been less effective on improving gait and postural stability...
  76. Real-time Gait Retraining to Reduce Loading in Runners
    Irene Davis; Fiscal Year: 2009
    ..determine whether these gait changes persist over a 6 month period...
  77. Long-term Ambulatory Gait Monitor for Parkinson's Disease
    Steven Moore; Fiscal Year: 2007
    ..of Parkinson's disease (PD) is locomotor dysfunction, such as small, variable stride length and freezing of gait. Treatment of PD to a large extent focuses on replacing depleted dopamine at the striatum to maintain mobility for ..
  78. Pain Assessment in Elders with Osteoarthritis
    Pao Feng Tsai; Fiscal Year: 2004
    ..This proposed pain assessment method contains two non-verbal OA pain indicators: motor and gait patterns...
  79. FES for foot-drop in hemiparesis
    John Chae; Fiscal Year: 2009
    ..Foot-drop, or inability to dorsiflex the paretic ankle during the swing phase of gait and ankle instability during stance phase are important gait abnormalities that contribute to reduced mobility ..
  80. Contralaterally Controlled NMES in Chronic Ankle Dorsiflexor Paresis after Stroke
    Jayme S Knutson; Fiscal Year: 2010
    ..A major contributor to impaired ambulation is the inability to dorsiflex the ankle during the swing phase of gait, which results in inefficient and unsafe ambulation or non-ambulation...
  81. High Force Resistance Training and Dopamine Replacement Effects on Hypokinesia in
    LELAND DIBBLE; Fiscal Year: 2007
    ..Collectively these factors lead to reductions in the size and speed (hypokinesia) of functional movements such as gait. Hypokinesia during gait initiation and gait are biomechanical events that can precipitates movement deficits such ..
  82. FALL BIOMECHANICS AND HIP FRACTURE RISK
    Wilson Hayes; Fiscal Year: 2004
    ..the previous funding period, we completed the goals of Aim 1: Dynamics of Side Falls, demonstrating that slow gait speed and the postural disturbances of slipping or fainting are associated with falls to the side and impact on the ..
  83. Analytical Tools for Optimizing Neurorehabilitation of Gait
    W Selbie; Fiscal Year: 2006
    ..1 limitation with these gait training protocols is that a number of key training variables are not well controlled for or understood, yet ..
  84. Polestriding versus Walking for PAD Rehabilitation
    Eileen Collins; Fiscal Year: 2009
    ..Patients with PAD of the lower extremities are subject to periods of intermittent claudication pain. Gait changes such as reduced stride length, cadence and walking speed are reported in patients with PAD...