shivering

Summary

Summary: Involuntary contraction or twitching of the muscles. It is a physiologic method of heat production in man and other mammals.

Top Publications

  1. ncbi Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy
    E G Elvan
    Hacettepe University, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Sihhiye, Ankara, Turkey
    Eur J Anaesthesiol 25:357-64. 2008
  2. ncbi Shivering and neuraxial anesthesia
    Larry J Crowley
    Department of Anesthesia, Intensive Care and Pain Medicine, Mater Misericordiae University Hospital, Dublin, Republic of Ireland
    Reg Anesth Pain Med 33:241-52. 2008
  3. ncbi Metabolic impact of shivering during therapeutic temperature modulation: the Bedside Shivering Assessment Scale
    Neeraj Badjatia
    Departments of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 39:3242-7. 2008
  4. ncbi Efficacy of prophylactic ketamine in preventing postoperative shivering
    D Dal
    Hacettepe University School of Medicine, Department of Anaesthesiology and Reanimation, Ankara 06100, Turkey
    Br J Anaesth 95:189-92. 2005
  5. ncbi Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse
    P Trayhurn
    Pflugers Arch 373:189-93. 1978
  6. ncbi Intraoperative high-dose remifentanil increases post-anaesthetic shivering
    M Nakasuji
    Department of Anesthesiology, Kansai Denryoku Hospital, 2 1 7 Fukushima, Fukushima ku, Osaka, Japan
    Br J Anaesth 105:162-7. 2010
  7. ncbi Dexmedetomidine and meperidine additively reduce the shivering threshold in humans
    Anthony G Doufas
    Outcomes Research Institute and the Department of Anesthesiology, Louisville, KY, USA
    Stroke 34:1218-23. 2003
  8. ncbi Intrathecal clonidine does not reduce post-spinal shivering
    Y T Jeon
    Department of Anesthesiology, Seoul National University Bundang Hospital, Seognam, Seoul, South Korea
    Acta Anaesthesiol Scand 49:1509-13. 2005
  9. ncbi Efficacy of granisetron in preventing postanesthetic shivering
    Parvin Sajedi
    Department of Anesthesia and Critical Care, Isfahan University of Medical Sciences, Isfahan, Iran
    Acta Anaesthesiol Taiwan 46:166-70. 2008
  10. ncbi Lipid mobilization of long-distance migrant birds in vivo: the high lipolytic rate of ruff sandpipers is not stimulated during shivering
    Eric Vaillancourt
    Biology Department, University of Ottawa, 30 Marie Curie, Ottawa, Ontario, K1N 6N5, Canada
    J Exp Biol 210:1161-9. 2007

Detail Information

Publications260 found, 100 shown here

  1. ncbi Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy
    E G Elvan
    Hacettepe University, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Sihhiye, Ankara, Turkey
    Eur J Anaesthesiol 25:357-64. 2008
    Post-anaesthetic shivering is one of the most common complications, occurring in 5-65% of patients recovering from general anaesthesia and 33% of patients receiving epidural anaesthesia...
  2. ncbi Shivering and neuraxial anesthesia
    Larry J Crowley
    Department of Anesthesia, Intensive Care and Pain Medicine, Mater Misericordiae University Hospital, Dublin, Republic of Ireland
    Reg Anesth Pain Med 33:241-52. 2008
    b>Shivering, which usually occurs as a thermoregulatory response to cold, may also occur following general or neuraxial anesthesia...
  3. ncbi Metabolic impact of shivering during therapeutic temperature modulation: the Bedside Shivering Assessment Scale
    Neeraj Badjatia
    Departments of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Stroke 39:3242-7. 2008
    Therapeutic temperature modulation is widely used in neurocritical care but commonly causes shivering, which can hamper the cooling process and result in increases in systemic metabolism...
  4. ncbi Efficacy of prophylactic ketamine in preventing postoperative shivering
    D Dal
    Hacettepe University School of Medicine, Department of Anaesthesiology and Reanimation, Ankara 06100, Turkey
    Br J Anaesth 95:189-92. 2005
    Treatment with ketamine and pethidine is effective in postoperative shivering. The aim of this study was to compare the efficacy of low-dose prophylactic ketamine with that of pethidine or placebo in preventing postoperative shivering.
  5. ncbi Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse
    P Trayhurn
    Pflugers Arch 373:189-93. 1978
    ..The obese animals therefore expend less energy on thermoregulatory thermogenesis. 5. The capacity for non-shivering thermogenesis was measured in lean and obese mice by investigating the effect of an injection of L-nor-..
  6. ncbi Intraoperative high-dose remifentanil increases post-anaesthetic shivering
    M Nakasuji
    Department of Anesthesiology, Kansai Denryoku Hospital, 2 1 7 Fukushima, Fukushima ku, Osaka, Japan
    Br J Anaesth 105:162-7. 2010
    Remifentanil is associated with increased incidence of post-anaesthetic shivering (PAS). The aim of this study was to compare the effects of intraoperative high and low doses of remifentanil on PAS.
  7. ncbi Dexmedetomidine and meperidine additively reduce the shivering threshold in humans
    Anthony G Doufas
    Outcomes Research Institute and the Department of Anesthesiology, Louisville, KY, USA
    Stroke 34:1218-23. 2003
    ..might prove to be therapeutically beneficial in stroke victims; however, even mild hypothermia provokes vigorous shivering. Meperidine and dexmedetomidine each linearly reduce the shivering threshold (triggering core temperature) with ..
  8. ncbi Intrathecal clonidine does not reduce post-spinal shivering
    Y T Jeon
    Department of Anesthesiology, Seoul National University Bundang Hospital, Seognam, Seoul, South Korea
    Acta Anaesthesiol Scand 49:1509-13. 2005
    After general or epidural anesthesia, clonidine is known to be effective in suppressing established shivering. The aim of this study was to assess the preventive effect of intrathecal clonidine on post-spinal shivering compared with ..
  9. ncbi Efficacy of granisetron in preventing postanesthetic shivering
    Parvin Sajedi
    Department of Anesthesia and Critical Care, Isfahan University of Medical Sciences, Isfahan, Iran
    Acta Anaesthesiol Taiwan 46:166-70. 2008
    Recently, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists have been reported to prevent postanesthetic shivering. This placebo-controlled study was performed to evaluate the efficacy of granisetron, a 5-HT3 antagonist, in comparison ..
  10. ncbi Lipid mobilization of long-distance migrant birds in vivo: the high lipolytic rate of ruff sandpipers is not stimulated during shivering
    Eric Vaillancourt
    Biology Department, University of Ottawa, 30 Marie Curie, Ottawa, Ontario, K1N 6N5, Canada
    J Exp Biol 210:1161-9. 2007
    ..Results show that shivering leads to a 47% increase in metabolic rate (44.4+/-3.8 ml O(2)kg(-1) min(-1) to 65.2+/-8...
  11. ncbi Effects of diabetes and food deprivation on shivering activity during progressive hypothermia in the rat
    R D Kilgour
    Department of Exercise Science, Concordia University, Montreal, Quebec, Canada
    Comp Biochem Physiol A Physiol 114:159-65. 1996
    ..The purpose of this study was to determine if shivering is attenuated in the urethane-anesthetized (1.5 g/kg; i.p...
  12. ncbi Effects of ramosetron and dexamethasone on postoperative nausea, vomiting, pain, and shivering in female patients undergoing thyroid surgery
    Yoon Kang Song
    Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, 344 2 Sinyong dong, Iksan, 570 711, Korea
    J Anesth 27:29-34. 2013
    Some antiemetics are effective in the treatment of postoperative pain and shivering, as well as for postoperative nausea and vomiting (PONV)...
  13. ncbi The efficacy of a single dose of pethidine, fentanyl and morphine in treating postanesthesia shivering
    Shideh Dabir
    Department of Anesthesiology and Critical Care, Tracheal Disease Research Center, National Research Institute of Tuberculosis and Lung Disease, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Pak J Pharm Sci 24:513-7. 2011
    Postanesthesia shivering is an undesirable event that may induce a variety of adverse consequences including patient discomfort, increased oxygen consumption and wound pain. Thus, its pharmacological treatment should be regarded...
  14. ncbi Ondansetron and meperidine prevent postoperative shivering after general anesthesia
    Masoud Entezari Asl
    Ardebil University of Medical Sciences, Iran
    Middle East J Anaesthesiol 21:67-70. 2011
    Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications...
  15. pmc Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition
    Viktor V Feketa
    Department of Molecular Physiology and Biophysics Graduate Program, Cardiovascular Sciences Track, Baylor College of Medicine, Houston, Texas
    Am J Physiol Regul Integr Comp Physiol 305:R1040-50. 2013
    ..induction of hypothermia in conscious stroke patients is complicated by cold-defensive responses, such as shivering and tachycardia...
  16. ncbi The effect of ondansetron and meperedin on preventing shivering after off-pump coronary artery bypass graft
    Mohammad Hassan Abdollahi
    Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
    Acta Med Iran 50:395-8. 2012
    One of the most common complications of operation and anesthesia is shivering. The purpose of this study was to compare the effectiveness of Ondanseton and Meperedine in preventing shivering after off-pump coronary artery bypass graft (..
  17. ncbi Tramadol for prevention of postanaesthetic shivering: a randomised double-blind comparison with pethidine
    M Mohta
    Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dehli, India
    Anaesthesia 64:141-6. 2009
    ..kg(-1) with pethidine 0.5 mg.kg(-1) for prophylaxis of postanaesthetic shivering and to find a dose of tramadol that could provide the dual advantage of antishivering and analgesic effect in ..
  18. ncbi Physostigmine prevents postanesthetic shivering as does meperidine or clonidine
    E P Horn
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 88:108-13. 1998
    Postanesthetic shivering develops in as many as one half of patients recovering from isoflurane anesthesia...
  19. pmc Dantrolene reduces the threshold and gain for shivering
    Chun Ming Lin
    Outcomes Research Institute, University of Louisville, Louisville, Kentucky 40202, USA
    Anesth Analg 98:1318-24, table of contents. 2004
    ..that dantrolene reduces the threshold (triggering core temperature) and gain (incremental increase) of shivering. Healthy volunteers were evaluated on 2 random days: control and dantrolene (approximately 2...
  20. pmc Ondansetron does not reduce the shivering threshold in healthy volunteers
    R Komatsu
    Outcomes Research Institute, University of Louisville, KY, USA
    Br J Anaesth 96:732-7. 2006
    Ondansetron, a serotonin-3 receptor antagonist, reduces postoperative shivering. Drugs that reduce shivering usually impair central thermoregulatory control, and may thus be useful for preventing shivering during induction of therapeutic ..
  21. ncbi Postanaesthetic shivering. Epidemiology, pathophysiology and approaches to prevention and management
    P Alfonsi
    Departement of Anesthesia and Resuscitation, Hôpital A Paré, Boulogne, France
    Minerva Anestesiol 69:438-42. 2003
    Postanaesthetic shivering is one of the leading causes of discomfort for patients recovering from general anesthesia...
  22. ncbi Prophylactic ondansetron does not prevent shivering or decrease shivering severity during cesarean delivery under combined spinal epidural anesthesia: a randomized trial
    Roger M Browning
    Department of Anaesthesia and Pain Medicine, Fremantle Hospital, Western Australia, Australia
    Reg Anesth Pain Med 38:39-43. 2013
    Cesarean delivery is commonly performed under regional anesthesia, which is often associated with maternal shivering. This can cause distress and interfere with monitoring...
  23. ncbi Urapidil does not prevent postanesthetic shivering: a dose-ranging study
    S N Piper
    Department of Anesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Ludwigshafen, Germany
    Can J Anaesth 48:742-7. 2001
    To investigate the effect of 0.2 mg x kg(-1), 0.3 mg x kg(-1) and 0.4 mg x kg(-1) urapidil on the incidence and severity of postanesthetic shivering.
  24. ncbi Side effects of oral misoprostol during the first 24 hours after administration in the third stage of labour
    Pisake Lumbiganon
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Thailand
    BJOG 109:1222-6. 2002
    ..To evaluate the side effects of 600 microg misoprostol orally during the first 24 hours after administration in the third stage of labour...
  25. pmc Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects
    Pascal Alfonsi
    Department of Anesthesia, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, France
    Anesthesiology 100:37-43. 2004
    ..does not compromise ventilation, is minimally sedating, and is effective as a treatment for postoperative shivering. The authors evaluated the effects of nefopam on the major thermoregulatory responses in humans: sweating, ..
  26. ncbi Comparative non-shivering thermogenesis in adjacent populations of the common spiny mouse (Acomys cahirinus) from opposite slopes: the effects of increasing salinity
    Michael Scantlebury
    Department of Biology, University of Haifa at Oranim, Tivon, Israel
    J Comp Physiol B 172:1-5. 2002
    We compared non-shivering thermogenesis between two adjacent populations of the common spiny mouse Acomys cahirinus from different habitats, in relation to increasing salinity...
  27. ncbi Effects of carbohydrate availability on sustained shivering I. Oxidation of plasma glucose, muscle glycogen, and proteins
    Francois Haman
    Biology Department, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Appl Physiol 96:32-40. 2004
    Carbohydrates (CHO) can play an important thermogenic role during shivering, but the effect of their availability on the use of other oxidative fuels is unclear...
  28. ncbi Lower-body warming mimics the normal epidural-induced reduction in the shivering threshold
    Anthony G Doufas
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
    Anesth Analg 106:252-6, table of contents. 2008
    Neuraxial anesthesia reduces the shivering threshold approximately 0.6 degrees C. This effect might be mediated by an apparent (as opposed to actual) increase in lower body temperature...
  29. pmc Central efferent pathways for cold-defensive and febrile shivering
    Kazuhiro Nakamura
    Career Path Promotion Unit for Young Life Scientists, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    J Physiol 589:3641-58. 2011
    b>Shivering is a remarkable somatomotor thermogenic response that is controlled by brain mechanisms...
  30. ncbi Prevention of shivering during therapeutic temperature modulation: the Columbia anti-shivering protocol
    H Alex Choi
    The Neurological Institute of New York, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Neurocrit Care 14:389-94. 2011
    ..of aggressive temperature control has become more commonplace, new clinical problems are arising, of which shivering is the most common...
  31. ncbi Transient shivering during Wada test provides insight into human thermoregulation
    Aashit K Shah
    Department of Neurology, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA
    Epilepsia 51:745-51. 2010
    Some patients with pharmacoresistant epilepsy undergoing the Wada test experience transient shivering. The purpose of this study was to investigate various clinical and radiographic characteristics of these individuals to delineate ..
  32. ncbi Non-thermoregulatory shivering in patients recovering from isoflurane or desflurane anesthesia
    E P Horn
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesthesiology 89:878-86. 1998
    Although cold-induced shivering is an obvious source of postanesthetic tremor, other causes may contribute...
  33. ncbi Effects of shivering prevention on haemodynamic and metabolic demands in hypothermic postoperative neurosurgical patients
    F Bilotta
    Department of Anaesthesia and Intensive Care, University of Rome La Sapienza Rome, Italy
    Anaesthesia 56:514-9. 2001
    We evaluated the haemodynamic and metabolic effects of prevention of shivering after prophylactic nefopam administration in neurosurgical patients undergoing craniotomy and mild systemic hypothermia (33-35 degrees C)...
  34. ncbi Double-blind comparison between doxapram and pethidine in the treatment of postanaesthetic shivering
    P Singh
    University Department of Anaesthesia, Queen s Medical Centre, Nottingham
    Br J Anaesth 71:685-8. 1993
    ..33 mg kg-1 (n = 20). Both doxapram and pethidine were effective in treating postoperative shivering 2-3 min after i.v. administration...
  35. ncbi An intraoperative small dose of ketamine prevents remifentanil-induced postanesthetic shivering
    Masato Nakasuji
    Department of Anesthesiology, Kansai Denryoku Hospital, 2 1 7 Fukushima, Fukushima ku, Osaka 553 0003, Japan
    Anesth Analg 113:484-7. 2011
    ..25 μg/kg/min), and epidural ropivacaine. Postanesthetic shivering (PAS) was evaluated for 30 minutes after emergence...
  36. ncbi Perioperative thermoregulation and heat balance
    D I Sessler
    Department of Anesthesia and Intensive Care, University of Vienna, Austria
    Ann N Y Acad Sci 813:757-77. 1997
    ..Fortunately, effective methods are available for preventing hypothermia...
  37. pmc High fever following postpartum administration of sublingual misoprostol
    J Durocher
    Gynuity Health Projects, New York, NY, USA
    BJOG 117:845-52. 2010
    ..To explore what triggers an elevated body temperature of > or =40.0 degrees C in some women given misoprostol, a prostaglandin E1 analogue, for postpartum haemorrhage (PPH)...
  38. pmc Fuel selection during intense shivering in humans: EMG pattern reflects carbohydrate oxidation
    Francois Haman
    Biology Department, University of Ottawa, 30 Marie Curie, Ottawa, Ontario, Canada K1N 6N5
    J Physiol 556:305-13. 2004
    ..of muscle recruitment could provide metabolic information on oxidative fuel selection during high-intensity shivering. EMG activity (of 8 large muscles) and fuel metabolism were monitored simultaneously in non-acclimatized adult ..
  39. ncbi Dolasetron for preventing postanesthetic shivering
    Swen N Piper
    Department of Anesthesiology and Critical Care Medicine, Klinikum Ludwigshafen, Ludwigshafen, Germany
    Anesth Analg 94:106-11, table of contents. 2002
    ..study to assess the efficacy of dolasetron compared with clonidine and placebo in prophylaxis of postanesthetic shivering. We included 90 patients undergoing elective abdominal or urologic surgery...
  40. ncbi Intrathecal fentanyl for prevention of shivering in cesarean section
    Anchalee Techanivate
    Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok 10330, Thailand
    J Med Assoc Thai 88:1214-21. 2005
    The aim of this randomized double-blind study was to investigate whether 20 microg of intrathecally administered fentanyl would influence the incidence and severity of shivering in patients undergoing cesarean section.
  41. ncbi Shivering thermogenesis in leg and breast muscles of galliform chicks and nestlings of the domestic pigeon
    K Marjoniemi
    Department of Biology, University of Oulu, P O Box 3000, FIN 90401 Oulu, Finland
    Physiol Biochem Zool 72:484-92. 1999
    We studied the ontogeny of shivering thermogenesis in breast and leg muscles of precocial galliforms (domestic fowl, grey partridge, and Japanese quail) and the altricial domestic pigeon using electromyography (EMG) and indirect ..
  42. ncbi Flumazenil improves cognitive and neuromotor emergence and attenuates shivering after halothane-, enflurane- and isoflurane-based anesthesia
    A A Weinbroum
    Post Anesthesia Care Unit, The Department Of Anesthesiology Critical Care Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Can J Anaesth 48:963-72. 2001
    ..To conduct a randomized, placebo-controlled, double-blinded, clinical experiment testing the hypothesis that flumazenil, a benzodiazepine antagonist, may affect recovery from halothane-, enflurane- and isoflurane-based anesthesia...
  43. ncbi Effect of amino acid solutions on intraoperative hypothermia and postoperative shivering. Comparison of two anesthetic regimens
    A Sahin
    Hacettepe University, Department of Anesthesiology and Reanimation, Ankara, Turkey
    Acta Anaesthesiol Scand 46:64-7. 2002
    ..The purpose of this study is to compare the effects of intraoperative administration of amino acid solutions on intraoperative hypothermia and postoperative shivering in two different anesthetic regimens.
  44. pmc Fuel selection in Wistar rats exposed to cold: shivering thermogenesis diverts fatty acids from re-esterification to oxidation
    Eric Vaillancourt
    University of Ottawa, Department of Biology, 30 Marie Curie, PO Box 450, Station A, Ottawa, Ontario, Canada K1N 6N5
    J Physiol 587:4349-59. 2009
    This study characterizes the effects of shivering thermogenesis on metabolic fuel selection in Wistar rats...
  45. ncbi Nefopam and alfentanil additively reduce the shivering threshold in humans whereas nefopam and clonidine do not
    Pascal Alfonsi
    Department of Anesthesia, Hopital Ambroise Pare, Boulogne France
    Anesthesiology 111:102-9. 2009
    Induction of therapeutic hypothermia is often complicated by shivering. Nefopam reduces the shivering threshold with minimal side effects. Consequently, nefopam is an attractive component for induction of therapeutic hypothermia...
  46. ncbi Control of shivering during regional anaesthesia: prophylactic ketamine and granisetron
    O Sagir
    Inonu University, School of Medicine, Malatya, Turkey
    Acta Anaesthesiol Scand 51:44-9. 2007
    The aim of the present study was to compare placebo, ketamine, granisetron and a combination of ketamine and granisetron in the prevention of shivering caused by regional anaesthesia.
  47. ncbi Nefopam and tramadol for the prevention of shivering during neuraxial anesthesia
    Federico Bilotta
    Department of Anesthesia and Intensive Care, University of Rome La Sapienza, Rome, Italy
    Reg Anesth Pain Med 27:380-4. 2002
    ..The shivering threshold is therefore reached soon, and more shivering is required to prevent further hypothermia...
  48. ncbi Intraoperative forced air-warming during cesarean delivery under spinal anesthesia does not prevent maternal hypothermia
    Alexander J Butwick
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    Anesth Analg 105:1413-9, table of contents. 2007
    Prewarming and intraoperative warming with forced air-warming systems prevent perioperative hypothermia and shivering in patients undergoing elective cesarean delivery with epidural anesthesia...
  49. ncbi Postanaesthetic shivering--a new look at tramadol
    S Mathews
    Department of Anaesthesia and ICU, Mubarak Al Kabir Hospital, Hawally, Kuwait
    Anaesthesia 57:394-8. 2002
    We studied whether tramadol administered at the time of wound closure can prevent postanaesthetic shivering. One hundred and fifty patients scheduled for general anaesthesia and surgery were randomly allocated and tramadol was ..
  50. ncbi Inhibition of shivering increases core temperature afterdrop and attenuates rewarming in hypothermic humans
    G G Giesbrecht
    Laboratory for Exercise and Environmental Medicine, Faculty of Medicine, University of Manitoba, Canada
    J Appl Physiol (1985) 83:1630-4. 1997
    During severe hypothermia, shivering is absent. To simulate severe hypothermia, shivering in eight mildly hypothermic subjects was inhibited with meperidine (1.5 mg/kg)...
  51. ncbi Comparison of prophylactic use of midazolam, ketamine, and ketamine plus midazolam for prevention of shivering during regional anaesthesia: a randomized double-blind placebo controlled trial
    A Honarmand
    Department of Anesthesiology and Intensive Care, Isfahan University of Medical Sciences, Isfahan, Iran
    Br J Anaesth 101:557-62. 2008
    ..The aim of the present study was to compare the efficacy of low-dose prophylactic midazolam with that of placebo, ketamine, and a combination of ketamine and midazolam in the prevention of shivering caused by regional anaesthesia.
  52. ncbi Meperidine exerts agonist activity at the alpha(2B)-adrenoceptor subtype
    Koji Takada
    Department of Anesthesia, Toyonaka Municipal Hospital, Osaka, Japan
    Anesthesiology 96:1420-6. 2002
    ..The authors therefore studied the ability of meperidine to bind and activate each of the alpha(2)-adrenoceptor subtypes in a transfected cell system...
  53. ncbi A comparison between meperidine, clonidine and urapidil in the treatment of postanesthetic shivering
    K R Schwarzkopf
    Department of Anesthesiology and Intensive Care Therapy, University Hospital, Jena, Germany
    Anesth Analg 92:257-60. 2001
    Postanesthetic shivering can be treated with many types of drugs. We compared the effects of meperidine, clonidine, and urapidil on postanesthetic shivering...
  54. ncbi Intrathecal meperidine decreases shivering during cesarean delivery under spinal anesthesia
    Jean Denis Roy
    Département d Anesthésiologie, Hopital Maisonneuve Rosemont, Universite de Montreal, 5415 Boul l Assomption, Montreal, Quebec, Canada H1T 2M4
    Anesth Analg 98:230-4, table of contents. 2004
    b>Shivering associated with spinal anesthesia is uncomfortable and may interfere with monitoring. We performed this prospective, double-blinded, and randomized study to determine whether intrathecal meperidine (0...
  55. ncbi Tramadol for postoperative shivering: a double-blind comparison with pethidine
    S Bhatnagar
    Unit of Anesthesiology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansani Nagar, New Delhi
    Anaesth Intensive Care 29:149-54. 2001
    In most operating and recovery rooms, shivering is controlled by the use of humidifiers, warming blankets, and inhalation of humidified heated oxygen. However, pharmacological control is an effective alternate treatment modality...
  56. ncbi The efficacy of ketamine for the treatment of postoperative shivering
    Emine Arzu Kose
    Department of Anesthesiology and Reanimation, Hacettepe University School of Medicine, Ankara, Turkey
    Anesth Analg 106:120-2, table of contents. 2008
    There are few reports on the utility of ketamine for the prevention of postoperative shivering. We thus established the efficacy of two doses of ketamine compared with meperidine for the treatment of postoperative shivering.
  57. ncbi Perioperative shivering: physiology and pharmacology
    Jan De Witte
    Department of Anesthesia and Intensive Care, OLV Hospital, Aalst, Belgium
    Anesthesiology 96:467-84. 2002
  58. ncbi Pharmacological treatment of postoperative shivering: a quantitative systematic review of randomized controlled trials
    Peter Kranke
    Department of Anesthesiology, University of Wurzburg, Germany
    Anesth Analg 94:453-60, table of contents. 2002
    b>Shivering is a frequent complication in the postoperative period. The relative efficacy of interventions that are used for the treatment of postoperative shivering is not well understood...
  59. ncbi Intramuscular ketamine for prevention of postanesthesia shivering in children
    Fouad A Zahra
    Department of Anesthesia and Intensive Care, King Abdulaziz Naval Base Hospital, Jubail, Kingdom of Saudi Arabia
    Saudi Med J 29:1255-9. 2008
    To compare the effects of intramuscular ketamine with pethidine and placebo on post operative shivering in children undergoing tonsillectomy.
  60. ncbi Postanaesthetic shivering: epidemiology, pathophysiology, and approaches to prevention and management
    P Alfonsi
    Département d Anaesthésie Réanimation, Hôpital A Paré, Boulogne, France
    Drugs 61:2193-205. 2001
    Along with nausea and vomiting, postanaesthetic shivering is one of the leading causes of discomfort for patients recovering from general anaesthesia...
  61. ncbi Pharmacokinetics and adverse-effect profile of rectally administered misoprostol in the third stage of labor
    Rehan Uddin Khan
    Division of Maternal and Fetal Medicine, Imperial College School of Medicine, London, United Kingdom
    Obstet Gynecol 101:968-74. 2003
    ..To characterize the pharmacokinetics and adverse-effect profile of rectally administered misoprostol...
  62. ncbi Single-dose parenteral pharmacological interventions for the prevention of postoperative shivering: a quantitative systematic review of randomized controlled trials
    Peter Kranke
    Department of Anesthesiology, University of Wurzburg, Oberdürrbacherstrasse 6, D 97080 Wurzburg, Germany
    Anesth Analg 99:718-27, table of contents. 2004
    b>Shivering is a frequent complication in the postoperative period. The relative efficacy of pharmacological interventions to prevent this phenomenon is not well understood...
  63. ncbi Buspirone and meperidine synergistically reduce the shivering threshold
    M Mokhtarani
    Department of Anesthesia, University of California, San Francisco, USA
    Anesth Analg 93:1233-9. 2001
    Mild hypothermia (i.e., 34 degrees C) may prove therapeutic for patients with stroke, but it usually provokes shivering. We tested the hypothesis that the combination of buspirone (a serotonin 1A partial agonist) and meperidine ..
  64. ncbi Magnesium sulfate infusion prevents shivering during transurethral prostatectomy with spinal anesthesia: a randomized, double-blinded, controlled study
    Muhammet Gozdemir
    Department of Anesthesiology and Reanimation, Fatih University School of Medicine, Ankara 06540, Turkey
    J Clin Anesth 22:184-9. 2010
    To determine whether magnesium sulfate (MgSO(4)) infusion during surgery reduces shivering during spinal anesthesia.
  65. ncbi A comparison of nefopam and clonidine for the prevention of postanaesthetic shivering: a comparative, double-blind and placebo-controlled dose-ranging study
    S N Piper
    Department of Anaesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Germany
    Anaesthesia 59:559-64. 2004
    Postanaesthetic shivering is a frequent complication following general anaesthesia...
  66. ncbi Cold-induced heat production preceding shivering
    Anne M J van Ooijen
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Br J Nutr 93:387-91. 2005
    Individual changes in heat production and body temperature were studied in response to cold exposure, prior to shivering. The subjects ten women (seven men) were of normal weight, had a mean age of 23 (SD 3) years and average BMI 22...
  67. ncbi Comparison of three warming devices for the prevention of core hypothermia and post-anaesthesia shivering
    C H Ihn
    Department of Anaesthesia and Pain Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Int Med Res 36:923-31. 2008
    ..a surgical access blanket in preventing a decrease in core temperature during anaesthesia and post-anaesthesia shivering (PAS) was compared with two widely used interventions comprising forced air warming combined with an upper body ..
  68. ncbi Dexmedetomidine and meperidine prevent postanaesthetic shivering
    C Bicer
    Department of Anaesthesiology and Intensive Care, Erciyes University, Kayseri, Turkey
    Eur J Anaesthesiol 23:149-53. 2006
    This placebo-controlled study was performed to evaluate the efficacy of dexmedetomidine compared with meperidine and placebo in preventing postanaesthetic shivering.
  69. ncbi Intraoperative tramadol reduces shivering but not pain after remifentanil-isoflurane general anaesthesia. A placebo-controlled, double-blind trial
    F Heid
    Johannes Gutenberg University, Department of Anaesthesiology, Mainz, Germany
    Eur J Anaesthesiol 25:468-72. 2008
    Postoperative shivering and pain are frequent problems in patients recovering from anaesthesia with particularly high incidences being observed after remifentanil-isoflurane-based general anaesthesia...
  70. ncbi Prophylactic ketamine reduces incidence of postanaesthetic shivering
    A Gecaj-Gashi
    University Clinical Centre of Kosovo, Clinic of Anaesthesiology and Intensive Care, Prishtina, Kosovo
    Niger J Med 19:267-70. 2010
    General anesthesia influences the thermoregulatory process. The aim of this study was to compare the efficacy of low-dose prophylactic ketamine with that of placebo in preventing postoperative shivering.
  71. ncbi Dexmedetomidine for the treatment of postanesthesia shivering in children
    R Blaine Easley
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institute, Baltimore, MD, USA
    Paediatr Anaesth 17:341-6. 2007
    b>Shivering is a common postanesthesia adverse event with multiple etiologies and multiple suggested prophylactic and abortive treatment regimens...
  72. ncbi Cold-acclimation-induced non-shivering thermogenesis in birds is associated with upregulation of avian UCP but not with innate uncoupling or altered ATP efficiency
    Loïc Teulier
    Universite de Lyon, CNRS, UMR5123, Laboratoire de Physiologie Integrative, Cellulaire et Moléculaire, F 69622 Villeurbanne, France
    J Exp Biol 213:2476-82. 2010
    Despite their lack of brown adipose tissue, some bird species develop regulatory non-shivering thermogenesis (NST) of skeletal muscle origin in response to cold acclimation...
  73. ncbi The effects of intravenous fluids temperature on perioperative hemodynamic situation, post-operative shivering, and recovery in orthopaedic surgery
    H Hasankhani
    Isfahan Medical University, Isfahan, Iran
    Can Oper Room Nurs J 25:20-4, 26-7. 2007
    ..This study was designed to evaluate the effects of warming intravenous fluids on perioperative hemodynamic situation, post-operative shivering and recovery in orthopaedic surgery patients.
  74. ncbi Dexmedetomidine does not alter the sweating threshold, but comparably and linearly decreases the vasoconstriction and shivering thresholds
    P Talke
    Department of Anesthesia, University of California, San Francisco 94143 0648, USA
    Anesthesiology 87:835-41. 1997
    Clonidine decreases the vasoconstriction and shivering thresholds. It thus seems likely that the alpha2 agonist dexmedetomidine will also impair control of body temperature...
  75. ncbi Suppression of shivering during hypothermia using a novel drug combination in healthy volunteers
    Rainer Lenhardt
    Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, Kentucky, USA
    Anesthesiology 111:110-5. 2009
    Hypothermia may be beneficial in stroke victims; however, it provokes vigorous shivering. Buspirone and dexmedetomidine each linearly reduce the shivering threshold with minimal sedation and no respiratory depression...
  76. ncbi The minimum effective doses of pethidine and doxapram in the treatment of post-anaesthetic shivering
    I J Wrench
    University Department of Anaesthesia, Queen s Medical Centre, Nottingham, UK
    Anaesthesia 52:32-6. 1997
    This study was designed to find the minimum effective doses of doxapram and pethidine to stop post-anaesthetic shivering. Two hundred and twenty healthy patients who shivered following routine surgery were allocated randomly to receive ..
  77. ncbi [Dolasetron and shivering. A prospective randomized placebo-controlled pharmaco-economic evaluation]
    M Bock
    Abteilung 1 für Anästhesie und Intensivmedizin, Zentralkrankenhaus, Lorenz Böhler Strasse 5, 39100 Bozen
    Anaesthesist 56:63-6, 68-70. 2007
    ..In the surgical field postoperative shivering reduces both patient comfort and medical quality...
  78. ncbi Optimum dose of ketamine for prevention of postanesthetic shivering; a randomized double-blind placebo-controlled clinical trial
    M Norouzi
    Department of Anesthesiology, Kerman University of Medical Sciences, Kerman, Iran
    Acta Anaesthesiol Belg 62:33-6. 2011
    Our objective was to investigate the efficacy and the optimum dosage of ketamine for post anesthetic shivering prevention...
  79. ncbi Doxapram after general anaesthesia. Its role in stopping shivering during recovery
    V Sarma
    Department of Anaesthetics, North Tees General Hospital, Hardwick, Stockton on Tees, Cleveland
    Anaesthesia 46:460-1. 1991
    A group of patients who developed postoperative shivering after receiving inhalational anaesthesia were assigned, at random, to receive either doxapram or a placebo under double-blind conditions...
  80. ncbi Lower limb wrapping prevents hypotension, but not hypothermia or shivering, after the introduction of epidural anesthesia for cesarean delivery
    Hsiao Lun Sun
    Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan
    Anesth Analg 99:241-4. 2004
    ..Moreover, we evaluated the effect of this maneuver as regards hypothermia and shivering. Sixty parturients were randomly allocated to receive either leg wrapping with tight elastic bandages (leg-..
  81. pmc Magnesium sulphate only slightly reduces the shivering threshold in humans
    A Wadhwa
    Outcomes Research Institute and Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, USA
    Br J Anaesth 94:756-62. 2005
    ..Hypothermia may be an effective treatment for stroke or acute myocardial infarction; however, it provokes vigorous shivering, which causes potentially dangerous haemodynamic responses and prevents further hypothermia...
  82. ncbi Physostigmine for the prevention of postanaesthetic shivering following general anaesthesia - a placebo-controlled comparison with nefopam
    K D Röhm
    Department of Anaesthesiology and Intensive Care Medicine, Klinkum Ludwigshafen, Germany
    Anaesthesia 60:433-8. 2005
    Physostigmine was studied for its efficacy in the prevention of postanaesthetic shivering compared to nefopam and placebo. We studied 89 patients undergoing abdominal and urological surgery...
  83. pmc Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study
    Oliver Kimberger
    Department of Anaesthesiology, University of Bern, CH 3010 Bern, Switzerland
    Crit Care 11:R29. 2007
    ..patient, even a small decrease of core temperature provokes vigorous autonomic reactions-vasoconstriction and shivering-which both inhibit efficient core cooling...
  84. pmc Partitioning oxidative fuels during cold exposure in humans: muscle glycogen becomes dominant as shivering intensifies
    Francois Haman
    Faculty of Health Sciences, University of Ottawa, 125 University St, Ottawa, Ontario, Canada K1N 6N5
    J Physiol 566:247-56. 2005
    The effects of changes in shivering intensity on the relative contributions of plasma glucose, muscle glycogen, lipids and proteins to total heat production are unclear in humans...
  85. ncbi Pethidine and skin warming to prevent shivering during endovascular cooling
    K Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Melbourne, Victoria
    Anaesth Intensive Care 32:362-7. 2004
    We tested the efficacy of pethidine and cutaneous warming to prevent shivering during percutaneous cooling in unanaesthetized patients. Ten patients scheduled for cranial neurosurgery received pethidine infusion and skin warming...
  86. ncbi Intrathecal meperidine for prevention of shivering during transurethral resection of prostate
    Maryam Davoudi
    Department of Anesthesiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
    Urol J 4:212-6. 2007
    The aim of this study was to investigate low-dose intrathecal meperidine for prevention or alleviation of shivering after induction of spinal anesthesia for transurethral resection of the prostate (TURP).
  87. ncbi Postoperative shivering in children: a review on pharmacologic prevention and treatment
    Peter Kranke
    Department of Anesthesiology, University of Wurzburg, Wurzburg, Germany
    Paediatr Drugs 5:373-83. 2003
    Postoperative shivering consists of muscular tremor and rigidity. It is often associated with body heat loss, although hypothermia alone does not fully explain the occurrence of shivering...
  88. ncbi A comparison of tramadol, amitriptyline, and meperidine for postepidural anesthetic shivering in parturients
    Y C Tsai
    Department of Anesthesiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Anesth Analg 93:1288-92. 2001
    Tramadol is effective for treating shivering during epidural anesthesia in parturients. In addition to its low affinity to opioid receptors, tramadol exerts a modulatory effect on central monoaminergic pathways...
  89. pmc Effect of postoperative skin-surface warming on oxygen consumption and the shivering threshold
    P Alfonsi
    Department of Anaesthesiology, Hôpital Ambroise Pare AP HP, 9 avenue Charles de Gaulle, Boulogne Billancourt 9, 2 100, France
    Anaesthesia 58:1228-34. 2003
    Cutaneous warming is reportedly an effective treatment for shivering during epidural and after general anaesthesia. We quantified the efficacy of cutaneous warming as a treatment for shivering...
  90. ncbi Side-effects of oral misoprostol in the third stage of labour--a randomised placebo-controlled trial
    G J Hofmeyr
    Department of Obstetrics and Gynaecology, Coronation Hospital and Effective Care Research Unit, University of the Witwatersrand, Johannesburg
    S Afr Med J 91:432-5. 2001
    ..Potential side-effects, however, need to be quantified. OBJECTIVE: To compare the rate of postpartum shivering and pyrexia following oral misoprostol 600 micrograms and placebo...
  91. ncbi Shivering in the cold: from mechanisms of fuel selection to survival
    Francois Haman
    Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Appl Physiol (1985) 100:1702-8. 2006
    ..are delayed by reducing heat loss via peripheral vasoconstriction and by increasing rates of heat production via shivering thermogenesis...
  92. ncbi Side effects of oral misoprostol for the prevention of postpartum hemorrhage: results of a community-based randomised controlled trial in rural India
    Shobhana S Patted
    Department of Obstetrics and Gynecology, Jawaharal Nehru Medical College, Belgaum, India
    J Matern Fetal Neonatal Med 22:24-8. 2009
    ..To investigate the side effects of 600 microg oral misoprostol given for the mother and the newborn to prevent postpartum hemorrhage (PPH)...
  93. ncbi Independent risk factors for postoperative shivering
    Leopold H J Eberhart
    Department of Anesthesiology and Critical Care, Philipps University Marburg, Baldingerstr 1, D 35033 Marburg, Germany
    Anesth Analg 101:1849-57. 2005
    Postoperative shivering (PAS) is uncomfortable for patients and potentially risky. In this observational trial we sought to identify independent risk factors for PAS after general anesthesia...
  94. ncbi Neither arm nor face warming reduces the shivering threshold in unanesthetized humans
    Anthony G Doufas
    Outcomes Research Institute, Department of Anesthesiology, University of Louisville, Louisville, KY, USA
    Stroke 34:1736-40. 2003
    Hand warming and face warming, combined with inhalation of heated air, are reported to suppress shivering. However, hand or face temperature contributes only a few percent to control of shivering...
  95. ncbi Cooling for Acute Ischemic Brain Damage (COOL AID): a feasibility trial of endovascular cooling
    M A De Georgia
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurology 63:312-7. 2004
    ..To report results of a randomized pilot clinical feasibility trial of endovascular cooling in patients with ischemic stroke...
  96. ncbi A trial of therapeutic hypothermia via endovascular approach in awake patients with acute ischemic stroke: methodology
    Kama Z Guluma
    Department of Emergency Medicine, University of California San Diego Medical Center, San Diego, CA 92103 8676, USA
    Acad Emerg Med 13:820-7. 2006
    ..its use in intubated, pharmacologically paralyzed patients, using surface cooling techniques that are susceptible to patient shivering, imprecise temperature control, time lag to target-temperature acquisition, and rebound hyperthermia.
  97. ncbi The effects of meperidine and sufentanil on the shivering threshold in postoperative patients. pascal.alfonsi@apr.ap-hop-paris.fr
    P Alfonsi
    Department of Anesthesia, Hopital Ambroise Pare, Boulogne Billancourt, France
    Anesthesiology 89:43-8. 1998
    BACKGROUND. Meperidine (pethidine) reportedly treats postoperative shivering better than equianalgesic doses of other mu-receptor agonists...
  98. ncbi Comparison of the effects of intrathecal morphine and pethidine on shivering after Caesarean delivery under combined-spinal epidural anaesthesia
    J Y Hong
    Department of Anaesthesiology, Samsung Cheil Hospital, Sungkyunkwan University, Mukjeong dong 1 19, Jung Gu, Seoul 100 380, South Korea
    Anaesthesia 60:1168-72. 2005
    ..2 mg morphine (group BM0.2; n = 30), or with 10 mg pethidine (group BPeth10; n = 30). The incidences of shivering were 23.3% (7/30) in group B, 17% (5/29) in group BM0.1, 13.3% (4/30) in group BM0.2 and 3...
  99. ncbi Comparison of ondansetron and meperidine for prevention of shivering in patients undergoing spinal anesthesia
    Ebru Kelsaka
    Department of Anesthesiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey
    Reg Anesth Pain Med 31:40-5. 2006
    ..Regional anesthesia, like general anesthesia, influences the thermoregulatory process. The aim of our study was to compare the efficacy of ondansetron and meperidine in the prevention of shivering during and after spinal anesthesia.
  100. ncbi Heat production and body temperature during cooling and rewarming in overweight and lean men
    Anne M J Claessens-van Ooijen
    Department of Human Biology, NUTRIM Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Obesity (Silver Spring) 14:1914-20. 2006
    ..To compare overweight and lean subjects with respect to thermogenesis and physiological insulation in response to mild cold and rewarming...
  101. ncbi Efficacy of postoperative rewarming after cardiac surgery
    Anselm Bräuer
    Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Götingen, Gottingen, Germany
    Ann Thorac Cardiovasc Surg 10:171-7. 2004
    ..To compare the efficacy of forced-air warmers and radiant heaters on rewarming after cardiac surgery in a prospective randomized study...

Research Grants43

  1. Misty: a model for central regulation of bone remodeling
    CLIFFORD JAMES ROSEN; Fiscal Year: 2013
    ..and increase resorption while in BAT, catecholamines act on [unreadable]3 adrenergic receptors to increase non-shivering thermogenesis...
  2. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..as by muscle paralysis) to allow body cooling and also to avoid clinical complications that accompany prolonged shivering such as increased oxygen consumption and hyperglycemia...
  3. Quantitative Assessment of Oxidative Metabolism in Brown Fat
    Otto Muzik; Fiscal Year: 2011
    ..by applicant): Brown adipose tissue (BAT or brown fat) is a thermogenic organ that plays a critical role in non- shivering thermogenesis with the purpose of generating heat in response to cold stress...
  4. Sympathetic Regulation of AMPK in the control of non-shivering thermogenesis
    Jacob D Mulligan; Fiscal Year: 2012
    ..to the regulation of body weight and temperature by controlling the thermogenic potential and amount of non-shivering thermogenesis in brown adipose. To test these hypotheses, three specific aims will be accomplished...
  5. Age and Control of Human Skin Flow
    W Larry Kenney; Fiscal Year: 2013
    ..Because core temperature excursions during even mild heating or cooling (i.e., in the absence of shivering or sweating) are greater in the elderly, altered vasomotor regulation is the seminal age-related deficit...
  6. Imaging Strategies to Measure Brown Fat and Its Activity
    C Ronald Kahn; Fiscal Year: 2010
    ..and inducible energy expenditure directly via thermogenesis, and skeletal muscle, which generates heat through shivering. Brown adipose tissue is of particular interest since recent studies suggest that in addition to its role in ..
  7. Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury
    Laurence M Katz; Fiscal Year: 2010
    ..However, physiological responses to forced cooling (shivering, vasoconstriction and release of stress hormones) reduce the efficacy of hypothermia...
  8. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun F Morrison; Fiscal Year: 2013
    ..thermoregulatory effectors: increased heat production from brown adipose tissue (BAT) thermogenesis, from shivering in skeletal muscle and from a marked tachycardia and increased heat conservation through cutaneous ..
  9. Role of thermoregulatory leptin action via the DMH in body weight control
    KAVON PAUL REZAI-ZADEH; Fiscal Year: 2013
    ..In the absence of efficient intervention strategies for curbing obesity, the promotion of non-shivering thermogenesis (NST) has re- emerged as a potentially viable approach...
  10. Recruitment of skeletal muscle based non-shivering thermogenesis in health and di
    Muthu Periasamy; Fiscal Year: 2013
    ..abstract_text> ..
  11. DEPENDENCE OF THERMOGENESIS AND BROWN ADIPOSE TISSUE FUNCTION ON FATP1 AND CD36
    Andreas Stahl; Fiscal Year: 2013
    ..Brown adipose tissue (BAT) is the primary organ for non-shivering thermogenesis and is found both in infants as well as adult humans...
  12. NIH Director's Pioneer Award
    Cheng C Lee; Fiscal Year: 2010
    ..b>Shivering, a sign of thermo-regulatory defense is blocked by 5?-AMP, allowing rapid cooling of CBT to 17oC or below, ..
  13. Role of desnutrin/ATGL in maintenance and function of brown adipose tissue
    Hei Sook Sul; Fiscal Year: 2013
    ..In contrast, brown adipose tissue (BAT) uses FA to activate uncoupling protein 1 (UCP1) for non-shivering thermogenesis to dissipate energy as heat...
  14. Biochemical regulation of mitochondrial uncoupling protein 3
    MONTE ALEXANDER KENASTON; Fiscal Year: 2010
    ..UCPs have diverse functions including non-shivering thermogenesis, expenditure of excess substrates, and reduction of reactive oxygen species...
  15. Role of B2 in Brown Fat Transcription and Development
    Hei Sook Sul; Fiscal Year: 2013
    ..energy storage that in excess results in obesity, brown adipose tissue (BAT) dissipates energy as heat via non-shivering thermogenesis...
  16. Targeting Central A1 Adenosine Receptors Induces Hypothermia for Stroke
    Kelly L Drew; Fiscal Year: 2013
    ..the mechanism used by hibernating animals to cool to near-ambient temperature and avoids the negative effects of shivering. In bypassing thermoregulatory defenses such as shivering, this research is highly significant because it is ..
  17. Stroke Treatment by Chemically-Induced Hypothermia
    Shan Ping Yu; Fiscal Year: 2012
    ..and reduce the "set point" of the central temperature control so that systemic hypothermia in the absence of shivering is promoted...
  18. Brown fat dynamics: elucidation of molecular drivers using hibernation as a model
    Sandra L Martin; Fiscal Year: 2013
    ..of BAT each year as they prepare for winter hibernation, and depend on tightly-regulated periods of non-shivering thermogenesis throughout winter hibernation...
  19. TRANSMEMBRANE SIGNALLING IN GENETIC OBESITY
    Kathryn LaNoue; Fiscal Year: 1993
    ..These include insulin resistance, varying degrees of hyperinsulinemia, impaired non-shivering thermogenesis, and slow norepinephrine turnover...
  20. NEURAL CONTROL OF TEMPERATURE REGULATION
    JACK BOULANT; Fiscal Year: 2006
    ..Responses include skin blood flow, evaporative heat loss (e.g., salivation/skin wetting, panting, sweating), shivering and non-shivering thermogenesis (via metabolic hormones and brown adipose tissue)...
  21. PERIANETHETIC TREMOR AND THERMOREGULATION
    Daniel Sessler; Fiscal Year: 1993
    ..Generalized postoperative tremor (which clinically resembles shivering) can also cause complications including an approximate 150% increase in metabolic rate, hypoxemia, would ..
  22. DRUG-INDUCED SHIVERING--EFFECTS OF A NURSING MEASURE
    BARBARA HOLTZCLAW; Fiscal Year: 1990
    This experimental study tests a nursing intervention to reduce drug-induced shivering related to amphotericin B. Predictors and consequences of shivering will be sought from patient responses and physiological correlates...
  23. Mechanisms of MDMA-induced hyperthermia
    Edward Mills; Fiscal Year: 2009
    ..acute MDMA intoxication is hyperthermia, a hyper-metabolic condition that stems from a dramatic increase in "non-shivering" metabolic thermogenesis in the setting of heat conservation (peripheral vasoconstriction)...
  24. Skin Cooling to Improve Orthostatic Tolerance
    CRAIG CRANDALL; Fiscal Year: 2005
    ..e. stroke volume, blood pressure, sympathetic nerve activity, etc.) without causing shivering or altering motor function...
  25. ROLE OF THYROID HORMONE IN BROWN ADIPOSE TISSUE FUNCTION
    Jorge Silva; Fiscal Year: 1991
    The long-term objective of this research is to understand the regulation of facultative non-shivering thermogenesis...
  26. DETRAINING IN HIBERNATORS
    DONALD HOYT; Fiscal Year: 1991
    ..maximum cold-induced rate of oxygen consumption (also know as summit metabolism or M max), and capacity for non-shivering thermogenesis. 2) Systemic changes: blood volume, whole blood hemoglobin, and resting heart rate...
  27. MOLECULAR GENETICS OF THERMOGENESIS
    LESLIE KOZAK; Fiscal Year: 2007
    Investigations in rodents have convincingly shown that increases in non-shivering thermogenesis (NTS) are extremely effective in reducing obesity...
  28. ION TRANSPORT MECHANISMS IN MITOCHONDRIA
    Keith Garlid; Fiscal Year: 1999
    ..UCP is a primary source of non-shivering thermogenesis, and its physiological role is to provide heat to small mammals and human infants, who are ..
  29. ROLE OF INSULIN AND IGF-1 ON BROWN ADIPOCYTES
    Yu Hua Tseng; Fiscal Year: 2003
    Brown adipose tissue (BAT) is specialized for non-shivering thermogenesis in neonates. Regulation of BAT activity is critical to maintain energy homeostasis...
  30. THERMAL IMAGING OF PERINATAL BEHAVIOR AND PHYSIOLOGY
    Jeffrey Alberts; Fiscal Year: 1993
    ..this laboratory suggest that infant rat pups' ultrasonic vocalization, oxygen utilization, respiration and non-shivering thermogenesis are functionally interrelated...
  31. Nitrous Oxide and Wound Infections
    Ozan Akca; Fiscal Year: 2006
    ..Confirming our hypothesis would thus allow clinicians to make a minor modification in anesthetic practice that might reduce the incidence of a complication responsible for considerable perioperative morbidity and cost. ..
  32. SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONS
    Daniel Sessler; Fiscal Year: 2001
    ..Since the cost of oxygen is trivial and the risks of oxygen administration are low, clinicians will easily be able to implement this treatment once we have demonstrated its benefits. ..
  33. CARDIOVASCULAR CONCOMITANTS OF ULTRASONIC VOCALIZATIONS
    Mark Blumberg; Fiscal Year: 2002
    ..Through these approaches, an integrated view of the varied mechanisms by which infant and adult mammals regulate cardiovascular function during physiological and behavioral challenges will emerge. ..
  34. BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHES
    Robert Freedman; Fiscal Year: 2009
    ....
  35. Sleep Disturbance in Menopause
    Robert Freedman; Fiscal Year: 2006
    ..In Study 5, we will determine the effects of elevated sympathetic activation on HFs and sleep using a stimulus that does not, by itself, disrupt sleep (orthostasis). ..
  36. CENTRAL REGULATION OF SYMPATHETIC ACTIVITY TO BROWN FAT
    Shaun F Morrison; Fiscal Year: 2010
    ..abstract_text> ..
  37. Behavioral state development in infants
    Mark Blumberg; Fiscal Year: 2009
    ..abstract_text> ..
  38. GENE THERAPY, OBESITY AND HYPOTHALAMIC SIGNALING
    Satya Kalra; Fiscal Year: 2005
    ..This new knowledge will be applied to the ultimate goal of site-directed gene delivery aimed at the newly identified vulnerable loci in hypothalamic signaling to curb overeating and abnormal weight gain. ..
  39. Role of Angiogenesis Following Stroke
    Patrick Lyden; Fiscal Year: 2006
    ..abstract_text> ..
  40. Spontaneous Arousals in "CHIME" Infants at Risk for SIDS
    ROBERT DARNALL; Fiscal Year: 2006
    ..Finally, we will examine the relationships among the level of arousal, post-conceptional age, sleep state, and other infant behaviors such as feeding that are also associated with changes in autonomic activity. ..
  41. Gene Expression in Leptin-Regulated Pathways
    ANTHONY FERRANTE; Fiscal Year: 2006
    ..Finally, the proposed project will provide him with new molecules and pathways to investigate, as he begins his independent career studying the molecular genetics of energy homeostasis and obesity. ..
  42. Hypothalamic Effector Mechanisms: Stress and Fever
    JOSEPH DIMICCO; Fiscal Year: 2007
    ..abstract_text> ..
  43. The Dorsomedial Hypothalamus and Responses to Stress
    JOSEPH DIMICCO; Fiscal Year: 2005
    ..The results may also suggest new applications and therapeutic mechanisms for the growing family of drugs influencing AII and its receptors. ..