ophthalmoscopy

Summary

Summary: Examination of the interior of the eye with an ophthalmoscope.

Top Publications

  1. ncbi Comparing neural networks and linear discriminant functions for glaucoma detection using confocal scanning laser ophthalmoscopy of the optic disc
    Christopher Bowd
    Hamilton Glaucoma Center, University of California, San Diego, La Jolla, California 92093, USA
    Invest Ophthalmol Vis Sci 43:3444-54. 2002
  2. ncbi High-resolution imaging with adaptive optics in patients with inherited retinal degeneration
    Jacque L Duncan
    Department of Ophthalmology, University of California, San Francisco School of Medicine, San Francisco, California 94143 0730, USA
    Invest Ophthalmol Vis Sci 48:3283-91. 2007
  3. pmc Perfusion abnormalities in children with cerebral malaria and malarial retinopathy
    Nicholas A V Beare
    St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, United Kingdom
    J Infect Dis 199:263-71. 2009
  4. ncbi High-resolution imaging of the photoreceptor layer in epiretinal membrane using adaptive optics scanning laser ophthalmoscopy
    Sotaro Ooto
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ophthalmology 118:873-81. 2011
  5. ncbi The source of moving particles in parafoveal capillaries detected by adaptive optics scanning laser ophthalmoscopy
    Akihito Uji
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Invest Ophthalmol Vis Sci 53:171-8. 2012
  6. ncbi Longitudinal profile of retinal ganglion cell damage after optic nerve crush with blue-light confocal scanning laser ophthalmoscopy
    Christopher Kai Shun Leung
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92093 0946, USA
    Invest Ophthalmol Vis Sci 49:4898-902. 2008
  7. pmc Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment
    Katherine E Talcott
    Department of Ophthalmology, Division of Preventive Medicine and Public Health, University of California at San Francisco, CA, USA
    Invest Ophthalmol Vis Sci 52:2219-26. 2011
  8. pmc Cone photoreceptor abnormalities correlate with vision loss in patients with Stargardt disease
    Yingming Chen
    University of Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 52:3281-92. 2011
  9. pmc Disruption of the retinal parafoveal capillary network in type 2 diabetes before the onset of diabetic retinopathy
    Johnny Tam
    UC Berkeley School of Optometry, Rm 485 Minor Hall, Berkeley, CA 94720 2020, USA
    Invest Ophthalmol Vis Sci 52:9257-66. 2011
  10. ncbi In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy
    Mathias W Seeliger
    Retinal Diagnostics Research Group, Tuebingen, Germany
    Vision Res 45:3512-9. 2005

Detail Information

Publications283 found, 100 shown here

  1. ncbi Comparing neural networks and linear discriminant functions for glaucoma detection using confocal scanning laser ophthalmoscopy of the optic disc
    Christopher Bowd
    Hamilton Glaucoma Center, University of California, San Diego, La Jolla, California 92093, USA
    Invest Ophthalmol Vis Sci 43:3444-54. 2002
    ....
  2. ncbi High-resolution imaging with adaptive optics in patients with inherited retinal degeneration
    Jacque L Duncan
    Department of Ophthalmology, University of California, San Francisco School of Medicine, San Francisco, California 94143 0730, USA
    Invest Ophthalmol Vis Sci 48:3283-91. 2007
    ..To investigate macular photoreceptor structure in patients with inherited retinal degeneration using high-resolution images and to correlate the findings with clinical phenotypes and genetic mutations...
  3. pmc Perfusion abnormalities in children with cerebral malaria and malarial retinopathy
    Nicholas A V Beare
    St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, United Kingdom
    J Infect Dis 199:263-71. 2009
    ..We aimed to examine retinal perfusion in children with CM by use of fluorescein angiography to investigate the pathophysiology of CM...
  4. ncbi High-resolution imaging of the photoreceptor layer in epiretinal membrane using adaptive optics scanning laser ophthalmoscopy
    Sotaro Ooto
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ophthalmology 118:873-81. 2011
    ..cell structural abnormalities identified on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO-SLO) with the severity of metamorphopsia and anatomic findings on spectral-domain optical coherence ..
  5. ncbi The source of moving particles in parafoveal capillaries detected by adaptive optics scanning laser ophthalmoscopy
    Akihito Uji
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Invest Ophthalmol Vis Sci 53:171-8. 2012
    To investigate the source of moving particles in parafoveal capillaries detected by adaptive optics scanning laser ophthalmoscopy (AO-SLO).
  6. ncbi Longitudinal profile of retinal ganglion cell damage after optic nerve crush with blue-light confocal scanning laser ophthalmoscopy
    Christopher Kai Shun Leung
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92093 0946, USA
    Invest Ophthalmol Vis Sci 49:4898-902. 2008
    ..To investigate the long-term longitudinal profile of retinal ganglion cell (RGC) damage after optic nerve crush with a new technique for in vivo imaging of RGCs...
  7. pmc Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment
    Katherine E Talcott
    Department of Ophthalmology, Division of Preventive Medicine and Public Health, University of California at San Francisco, CA, USA
    Invest Ophthalmol Vis Sci 52:2219-26. 2011
    ..To study cone photoreceptor structure and function in patients with inherited retinal degenerations treated with sustained-release ciliary neurotrophic factor (CNTF)...
  8. pmc Cone photoreceptor abnormalities correlate with vision loss in patients with Stargardt disease
    Yingming Chen
    University of Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 52:3281-92. 2011
    ..METHODS. High-resolution images of the macula were obtained with adaptive optics scanning laser ophthalmoscopy (AOSLO) and spectral domain optical coherence tomography in 12 patients with STGD and 27 age-matched healthy ..
  9. pmc Disruption of the retinal parafoveal capillary network in type 2 diabetes before the onset of diabetic retinopathy
    Johnny Tam
    UC Berkeley School of Optometry, Rm 485 Minor Hall, Berkeley, CA 94720 2020, USA
    Invest Ophthalmol Vis Sci 52:9257-66. 2011
    To establish, using adaptive optics scanning laser ophthalmoscopy (AOSLO), that the retinal parafoveal capillary network is altered before the onset of diabetic retinopathy in adult patients with type 2 diabetes.
  10. ncbi In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy
    Mathias W Seeliger
    Retinal Diagnostics Research Group, Tuebingen, Germany
    Vision Res 45:3512-9. 2005
    Scanning-laser ophthalmoscopy is a technique for confocal imaging of the eye in vivo...
  11. pmc Tracking longitudinal retinal changes in experimental ocular hypertension using the cSLO and spectral domain-OCT
    Li Guo
    Visual Neuroscience, UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:6504-13. 2010
    ..The aim of this study was to test, first, whether the outer retina is affected in experimental ocular hypertension (OHT) and, second, whether whole retinal thickness can be used as a surrogate marker of glaucomatous change...
  12. pmc The effect of cone opsin mutations on retinal structure and the integrity of the photoreceptor mosaic
    Joseph Carroll
    Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Invest Ophthalmol Vis Sci 53:8006-15. 2012
    ..To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations...
  13. ncbi High-resolution imaging of resolved central serous chorioretinopathy using adaptive optics scanning laser ophthalmoscopy
    Sotaro Ooto
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ophthalmology 117:1800-9, 1809.e1-2. 2010
    ..central serous chorioretinopathy (CSC) seen on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO SLO) with visual acuity (VA) and findings on spectral-domain optical coherence tomography (SD OCT).
  14. ncbi Optical coherence tomography for ultrahigh resolution in vivo imaging
    James G Fujimoto
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 21:1361-7. 2003
    ..It is a promising imaging technology because it can provide images of tissue in situ and in real time, without the need for excision and processing of specimens...
  15. ncbi Clinical course, genetic etiology, and visual outcome in cone and cone-rod dystrophy
    Alberta A H J Thiadens
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 119:819-26. 2012
    ..To evaluate the clinical course, genetic etiology, and visual prognosis in patients with cone dystrophy (CD) and cone-rod dystrophy (CRD)...
  16. ncbi Effect of statin drugs and aspirin on progression in open-angle glaucoma suspects using confocal scanning laser ophthalmoscopy
    Dawn K De Castro
    Department of Ophthalmology, University of California at San Francisco, San Francisco, California 94143 0730, USA
    Clin Experiment Ophthalmol 35:506-13. 2007
    To determine the effect of statins and aspirin on the rate of progression of optic nerve parameters in open-angle glaucoma (OAG) suspects, as defined by confocal scanning laser ophthalmoscopy (CSLO).
  17. ncbi Normal age-related decay of retinal nerve fiber layer thickness
    Rajul S Parikh
    L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 114:921-6. 2007
    ..To determine the normal age-related loss of retinal nerve fiber layer thickness (RNFLT) as measured on Stratus optical coherence tomography (OCT 3; Carl Zeiss Meditec, Dublin, CA) in an Asian Indian population...
  18. ncbi Longitudinal profile of retinal ganglion cell damage assessed with blue-light confocal scanning laser ophthalmoscopy after ischaemic reperfusion injury
    C K S Leung
    Hamilton Glaucoma Center, University of California, San Diego, La Jolla, CA 92093 0946, USA
    Br J Ophthalmol 93:964-8. 2009
    ....
  19. ncbi Fundus autofluorescence imaging of retinal dystrophies
    Camiel J F Boon
    Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Philips van Leydenlaan 15, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Vision Res 48:2569-77. 2008
    ..A broad range of characteristic FAF patterns was observed. Our results indicate that FAF imaging constitutes a useful additive tool in the diagnosis and follow-up of various retinal dystrophies...
  20. ncbi Spectral-domain optical coherence tomography with multiple B-scan averaging for enhanced imaging of retinal diseases
    Atsushi Sakamoto
    Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ophthalmology 115:1071-1078.e7. 2008
    ..To determine whether multiple B-scan averaging improves the quality of spectral-domain optical coherence tomography (SD OCT) images of the retina...
  21. ncbi The reflectance of single cones in the living human eye
    Aristofanis Pallikaris
    Department of Biomedical Engineering, University of Rochester, Rochester, New York 14672, USA
    Invest Ophthalmol Vis Sci 44:4580-92. 2003
    ..To help understand what produces this spatial variation, the investigators explored whether it is a static or a dynamic property of the cone mosaic...
  22. ncbi Near-infrared autofluorescence imaging of the fundus: visualization of ocular melanin
    Claudia N Keilhauer
    Department of Ophthalmology, University Hospital, Wurzburg, Germany
    Invest Ophthalmol Vis Sci 47:3556-64. 2006
    To evaluate the origin of the near-infrared autofluorescence (AF) of the fundus detected by scanning laser ophthalmoscopy and compare the distribution of this AF with that of lipofuscin.
  23. ncbi Photoreceptor damage and foveal sensitivity in surgically closed macular holes: an adaptive optics scanning laser ophthalmoscopy study
    Sotaro Ooto
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Ophthalmol 154:174-186.e2. 2012
    To assess photoreceptor structure using adaptive optics scanning laser ophthalmoscopy (AO SLO) and spectral-domain optical coherence tomography (SD OCT) and to evaluate the relationship between structural abnormalities and foveal ..
  24. pmc Speed quantification and tracking of moving objects in adaptive optics scanning laser ophthalmoscopy
    Johnny Tam
    University of California, Berkeley and University of California, San Francisco, Joint Graduate Group in Bioengineering, Berkeley, California 94720, USA
    J Biomed Opt 16:036002. 2011
    ..The proposed methods performed well on both experimental AOSLO videos as well as synthetic videos generated by a virtual AOSLO. These methods improve the accuracy of methods to investigate hemodynamics using AOSLO imaging...
  25. ncbi In vivo imaging of murine retinal ganglion cells
    Christopher K S Leung
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA, United States
    J Neurosci Methods 168:475-8. 2008
    ....
  26. pmc Pulsatility of parafoveal capillary leukocytes
    Joy A Martin
    University of Houston, College of Optometry, Houston, TX 77004 2020, USA
    Exp Eye Res 88:356-60. 2009
    ..By controlling for the variation in leukocyte velocity caused by the cardiac cycle, we can better detect other changes in retinal leukocyte velocity induced by disease or pharmaceutical agents...
  27. pmc Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform
    Wei Song
    Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60208, USA
    J Biomed Opt 17:061206. 2012
    Photoacoustic ophthalmoscopy (PAOM) is a newly developed retinal imaging technology that holds promise for both fundamental investigation and clinical diagnosis of several blinding diseases...
  28. ncbi High-resolution retinal imaging of cone-rod dystrophy
    Jessica I Wolfing
    Center for Visual Science, University of Rochester, Rochester, New York 14627, USA
    Ophthalmology 113:1019.e1. 2006
    ..To date, adaptive optics ophthalmoscopy has been used mainly to examine the normal retina...
  29. ncbi Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study
    Linda M Zangwill
    Hamilton Glaucoma Center and Diagnostic Imaging Laboratory, Department of Ophthalmology, University of California San Diego, La Jolla, CA 92093, USA
    Arch Ophthalmol 123:1188-97. 2005
    To determine whether baseline confocal scanning laser ophthalmoscopy (CSLO) optic disc topographic measurements are associated with the development of primary open-angle glaucoma (POAG) in individuals with ocular hypertension.
  30. pmc Cone structure in retinal degeneration associated with mutations in the peripherin/RDS gene
    Jacque L Duncan
    Department of Ophthalmology, UCSF School of Medicine, 10 Koret Way, Room K 129, San Francisco, CA 94143 0730, USA
    Invest Ophthalmol Vis Sci 52:1557-66. 2011
    ..To study cone photoreceptor structure and function associated with mutations in the second intradiscal loop region of peripherin/RDS...
  31. ncbi Optical coherence tomography predictive factors for macular hole surgery outcome
    J M Ruiz-Moreno
    Albacete Medical School, University of Castilla La Mancha, Albacete, Spain
    Br J Ophthalmol 92:640-4. 2008
    ..To evaluate the use of preoperative optical coherence tomography (OCT) findings as predictive factors for macular hole (MH) surgery outcomes...
  32. pmc High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy
    Kohei Takayama
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 7:e33158. 2012
    To conduct high-resolution imaging of the retinal nerve fiber layer (RNFL) in normal eyes using adaptive optics scanning laser ophthalmoscopy (AO-SLO).
  33. ncbi Pain in neonates during screening for retinopathy of prematurity using binocular indirect ophthalmoscopy and wide-field digital retinal imaging: a randomised comparison
    C A Dhaliwal
    Centre for Reproductive Biology, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Arch Dis Child Fetal Neonatal Ed 95:F146-8. 2010
    To compare the pain experienced by premature infants undergoing wide-field digital retinal imaging (WFDRI) and binocular indirect ophthalmoscopy (BIO) for retinopathy of prematurity (ROP) screening.
  34. ncbi High-resolution photoreceptor imaging in idiopathic macular telangiectasia type 2 using adaptive optics scanning laser ophthalmoscopy
    Sotaro Ooto
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 52:5541-50. 2011
    To study pathologic changes in the photoreceptors in eyes with idiopathic macular telangiectasia (MacTel) type 2 using adaptive optics scanning laser ophthalmoscopy (AO-SLO).
  35. pmc The inner segment/outer segment border seen on optical coherence tomography is less intense in patients with diminished cone function
    Donald C Hood
    Department of Psychology, Columbia University, New York, New York 10027, USA
    Invest Ophthalmol Vis Sci 52:9703-9. 2011
    ..To better understand the influence of cones on the appearance of this band, the intensity of its signal in patients with diminished cone function was examined...
  36. pmc Assessment of rates of structural change in glaucoma using imaging technologies
    K Mansouri
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, CA, USA
    Eye (Lond) 25:269-77. 2011
    ..To review the ability of current imaging technologies to provide estimates of rates of structural change in glaucoma patients...
  37. ncbi Longitudinal variability of optic disc and retinal nerve fiber layer measurements
    Christopher Kai Shun Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
    Invest Ophthalmol Vis Sci 49:4886-92. 2008
    To evaluate the longitudinal variability of optic disc and retinal nerve fiber layer (RNFL) measurements obtained from optical coherence tomography (OCT), scanning laser polarimetry (SLP), and confocal scanning laser ophthalmoscopy (CSLO).
  38. ncbi Confocal scanning laser ophthalmoscopy findings in chronic solar retinopathy
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, 53127 Bonn, Germany
    Ophthalmic Surg Lasers Imaging 39:497-9. 2008
    A 68-year-old man with solar retinopathy had a lamellar foveal lesion on ophthalmoscopy and optical coherence tomography in one eye while the fellow eye appeared unremarkable...
  39. ncbi Long-term follow-up after macular hole surgery with internal limiting membrane peeling
    Christos Haritoglou
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Am J Ophthalmol 134:661-6. 2002
    ..To report long-term anatomical and functional results after pars plana vitrectomy with peeling of the internal limiting membrane (ILM) for idiopathic macular hole...
  40. ncbi Structure-function relationship between FDF, FDT, SAP, and scanning laser ophthalmoscopy in glaucoma patients
    Julia Lamparter
    Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Invest Ophthalmol Vis Sci 53:7553-9. 2012
    ..It is the purpose of this study to investigate the structure-function relationship between FDF, FDT, SAP, and confocal scanning laser ophthalmoscopy (cSLO) in patients with glaucoma.
  41. pmc Comparison of optic nerve head assessment with a digital stereoscopic camera (discam), scanning laser ophthalmoscopy, and stereophotography
    Anthony J Correnti
    New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Ophthalmology 110:1499-505. 2003
    ..Hereford, UK), confocal scanning laser ophthalmoscopy (CSLO), and stereoscopic disc photography with respect to optic nerve head (ONH) measurements and glaucoma ..
  42. ncbi Agreement in assessing cup-to-disc ratio measurement among stereoscopic optic nerve head photographs, HRT II, and Stratus OCT
    Stella N Arthur
    Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    J Glaucoma 15:183-9. 2006
    ....
  43. pmc Macular holes and macular pucker: the role of vitreoschisis as imaged by optical coherence tomography/scanning laser ophthalmoscopy
    Jerry Sebag
    VMR Institute, Huntington Beach, California, USA
    Trans Am Ophthalmol Soc 105:121-9; discusion 129-31. 2007
    ..Anomalous posterior vitreous detachment (PVD) and vitreoschisis have been proposed as possible mechanisms. This study used clinical imaging to seek vitreoschisis and study the topographic features of macular pucker and macular holes...
  44. pmc Design of an integrated hardware interface for AOSLO image capture and cone-targeted stimulus delivery
    Qiang Yang
    Montana State University, Bozeman, MT 59717, USA
    Opt Express 18:17841-58. 2010
    ..15 arcminutes from 0.26 arcminutes in our earlier solution. We also demonstrate the new FPGA solution is capable of delivering stabilized large stimulus pattern (up to 256 x 256 pixels) to the retina...
  45. ncbi Adaptive optics scanning laser ophthalmoscopy images in a family with the mitochondrial DNA T8993C mutation
    Michael K Yoon
    Department of Ophthalmology, University of California, San Francisco, California 94143 0730, USA
    Invest Ophthalmol Vis Sci 50:1838-47. 2009
    ..This study was designed to assess the effect of mitochondrial DNA (mtDNA) mutation T8993C on cone structure in a family expressing neurogenic muscle weakness, ataxia, and retinitis pigmentosa (NARP) syndrome...
  46. ncbi High resolution fundus imaging by confocal scanning laser ophthalmoscopy in the mouse
    Michel Paques
    Laboratory of Cellular and Molecular Physiopathology of the Retina, National Institute for Health and Medical Research, INSERM Unité 592, Paris, France
    Vision Res 46:1336-45. 2006
    ..We concluded that cSLO is a promising tool for noninvasive, multimodal intravital microscopy of the fundus in the mouse...
  47. pmc Inactivation of the murine X-linked juvenile retinoschisis gene, Rs1h, suggests a role of retinoschisin in retinal cell layer organization and synaptic structure
    Bernhard H F Weber
    Institute of Human Genetics, Biocenter, University of Wurzburg, D 97074 Wurzburg, Germany
    Proc Natl Acad Sci U S A 99:6222-7. 2002
    ....
  48. ncbi Optical fiber properties of individual human cones
    Austin Roorda
    University of Houston College of Optometry, Houston, TX, USA
    J Vis 2:404-12. 2002
    ..The implication is that the optical fiber properties of an ensemble of cones mimic the tuning properties of a single cone...
  49. ncbi Fundus autofluorescence imaging: review and perspectives
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 28:385-409. 2008
    ..Its clinical value coupled with its simple, efficient, and noninvasive nature is increasingly appreciated. This review summarizes basic principles and FAF findings in various retinal diseases...
  50. ncbi Retromode retinal imaging of macular retinoschisis in highly myopic eyes
    Yuichiro Tanaka
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Ophthalmol 149:635-640.e1. 2010
    ....
  51. ncbi In vivo visualization of dendritic cells, macrophages, and microglial cells responding to laser-induced damage in the fundus of the eye
    Nicole Eter
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 49:3649-58. 2008
    ..e., dendritic cells [DCs] and macrophages [MPhis]) in the posterior eye segment after laser-induced injury, and to gain a better understanding of the role of these cells in inflammatory eye disease...
  52. ncbi Use of optical coherence tomography (OCT) and indirect ophthalmoscopy in the diagnosis of macular edema in diabetic patients
    R O Moreira
    State Institute of Diabetes and Endocrinology (IEDE, Rio de Janeiro, RJ, Brazil
    Int Ophthalmol 24:331-6. 2001
    ..Tomography (OCT) in the diagnosis of macular edema (ME) in diabetic patients in comparison to indirect ophthalmoscopy (IO) and, in addition, to study the characteristics of these patients...
  53. pmc The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results
    Francesca Mojana
    Jacobs Retina Center at the Shiley Eye Center, Department of Ophthalmology, University of California San Diego, La Jolla, California, USA
    Am J Ophthalmol 146:218-227. 2008
    ....
  54. ncbi Screening by ophthalmoscopy for Toxoplasma retinochoroiditis in Colombia
    Alejandra de-la-Torre
    Molecular Parasitology Study Group GEPAMOL, Universidad del Quindio, Armenia, Columbia
    Am J Ophthalmol 143:354-6. 2007
    ..To measure the prevalence of toxoplasmic retinal scars in a young universitary population...
  55. pmc Applications of adaptive optics scanning laser ophthalmoscopy
    Austin Roorda
    School of Optometry, University of California Berkeley, Berkeley, CA 94720 2020, USA
    Optom Vis Sci 87:260-8. 2010
    ..AO systems have been demonstrated for advanced ophthalmoscopy as well as for testing and/or improving vision...
  56. ncbi Optic disc measurements in myopia with optical coherence tomography and confocal scanning laser ophthalmoscopy
    Christopher Kai Shun Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China
    Invest Ophthalmol Vis Sci 48:3178-83. 2007
    ..To evaluate the relationships between optic disc measurements, obtained by an optical coherence tomograph and a confocal scanning laser ophthalmoscope, and myopia...
  57. ncbi Dissociated optic nerve fiber layer appearance after internal limiting membrane peeling for idiopathic macular holes
    Yasuki Ito
    Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan
    Ophthalmology 112:1415-20. 2005
    ..To investigate the characteristics and incidence of a dissociated optic nerve fiber layer (DONFL) appearance in eyes after idiopathic macular hole surgery...
  58. pmc Detection of glaucoma using operator-dependent versus operator-independent classification in the Heidelberg retinal tomograph-III
    N Harizman
    Department of Ophthalmology, New York University School of Medicine, 310 East 14th Street, Suite 304, New York, NY 10003, USA
    Br J Ophthalmol 90:1390-2. 2006
    ....
  59. ncbi Confocal scanning laser ophthalmoscopy in high myopic eyes in a population-based setting
    Tae Tsutsumi
    Department of Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
    Invest Ophthalmol Vis Sci 50:5281-7. 2009
    To compare the parameters of confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph [HRT] II; Heidelberg Engineering, Heidelberg, Germany) in high myopia with those in age-matched emmetropia.
  60. ncbi Sensitivity and specificity of digital retinal imaging for screening diabetic retinopathy
    J Lopez-Bastida
    Evaluation and Planning Unit, Canary Islands Health Service, Canary Islands, Spain
    Diabet Med 24:403-7. 2007
    ..To assess the effectiveness of a non-mydriatic digital camera (45 degrees -30 degrees photographs) compared with the reference method for screening diabetic retinopathy...
  61. ncbi Angiographic analysis of retinal-choroidal anastomosis by confocal scanning laser ophthalmoscopy technology and corresponding (eye-tracked) spectral-domain optical coherence tomography
    Giuseppe Querques
    Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris XII, Creteil, France
    Retina 30:222-34. 2010
    The purpose of this study was to analyze the angiographic (confocal scanning laser ophthalmoscopy technology) and corresponding (eye-tracked) spectral-domain optical coherence tomography (SD-OCT) features and to propose a classification ..
  62. ncbi Observations by spectral-domain optical coherence tomography combined with simultaneous scanning laser ophthalmoscopy: imaging of the vitreous
    Francesca Mojana
    Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, La Jolla, California, USA
    Am J Ophthalmol 149:641-50. 2010
    ..the ability to detect normal vitreous structure, evolving posterior vitreous detachment (PVD), and related vitreoretinal changes with combined spectral-domain optical coherence tomography (SD-OCT) and scanning laser ophthalmoscopy (SLO).
  63. ncbi The effectiveness of screening for diabetic retinopathy by digital imaging photography and technician ophthalmoscopy
    P H Scanlon
    Gloucestershire Eye Unit, Cheltenham General Hospital, Cheltenham, Oxford Eye Hospital, Oxford, UK
    Diabet Med 20:467-74. 2003
    ..of a community-based non-mydriatic and mydriatic digital photographic screening programme by measuring the sensitivity and specificity compared with a reference standard and assessing the added value of technician direct ophthalmoscopy.
  64. ncbi Assessing sodium iodate-induced outer retinal changes in rats using confocal scanning laser ophthalmoscopy and optical coherence tomography
    Yaping Yang
    Department of Ophthalmology and Visual Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Invest Ophthalmol Vis Sci 55:1696-705. 2014
    ..We investigated a new approach of analyzing retinal images using confocal scanning laser ophthalmoscopy (cSLO) that allows longitudinal assessment of sodium iodate-induced lesions in the retina of living rats.
  65. ncbi Comparison of retinal nerve fiber layer imaging by spectral domain optical coherence tomography and scanning laser ophthalmoscopy
    Cong Ye
    Department of Ophthalmology and Visual Sciences, The Chinese Uniersity of Hong Kong, Hong Kong, People s Republic of China
    Ophthalmology 118:2196-202. 2011
    To compare the area and the angular width of localized retinal nerve fiber layer (RNFL) defects imaged by confocal scanning laser ophthalmoscopy (CSLO) and optical coherence tomography (OCT) and to evaluate their agreement.
  66. ncbi Racial differences in optic disc topography: baseline results from the confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study
    Linda M Zangwill
    Department of Ophthalmology, University of California, San Diego, La Jolla 92093, USA
    Arch Ophthalmol 122:22-8. 2004
    ..To examine racial differences in optic disc topography among ocular hypertensive participants in the Ocular Hypertension Treatment Study...
  67. pmc Multimodal photoacoustic ophthalmoscopy in mouse
    Wei Song
    Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Rd, Evanston IL 60208, USA
    J Biophotonics 6:505-12. 2013
    Photoacoustic ophthalmoscopy (PAOM) is a novel imaging technology that measures optical absorption in the retina...
  68. ncbi Multifocal retinal contraction in macular pucker analyzed by combined optical coherence tomography/scanning laser ophthalmoscopy
    Priya Gupta
    VMR Institute, Huntington Beach, CA 92647, USA
    Retina 28:447-52. 2008
    ..To characterize the topography of macular pucker using coronal plane imaging in vivo, and correlate this with transverse optical coherence tomography (OCT) to assess the relationship between topographic features and severity of disease...
  69. ncbi High-resolution imaging of retinal nerve fiber bundles in glaucoma using adaptive optics scanning laser ophthalmoscopy
    Kohei Takayama
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Ophthalmol 155:870-81. 2013
    To detect pathologic changes in retinal nerve fiber bundles in glaucomatous eyes seen on images obtained by adaptive optics (AO) scanning laser ophthalmoscopy (AO SLO).
  70. ncbi Adaptive optics ophthalmoscopy
    A Roorda
    University of Houston College of Optometry, TX, USA
    J Refract Surg 16:S602-7. 2000
    ..Application of adaptive optics technology for ophthalmoscopy promises continued progress toward understanding the basic properties of the living human retina and also for ..
  71. ncbi Comparison of cone pathologic changes in idiopathic macular telangiectasia types 1 and 2 using adaptive optics scanning laser ophthalmoscopy
    Sotaro Ooto
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Ophthalmol 155:1045-1057.e4. 2013
    To compare pathologic changes in the photoreceptors of eyes with idiopathic macular telangiectasia types 1 and 2 using adaptive optics scanning laser ophthalmoscopy (AO-SLO).
  72. ncbi Noninvasive and direct monitoring of erythrocyte aggregates in human retinal microvasculature using adaptive optics scanning laser ophthalmoscopy
    Shigeta Arichika
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 54:4394-402. 2013
    To investigate erythrocyte aggregates in parafoveal capillaries by adaptive optics scanning laser ophthalmoscopy (AO-SLO).
  73. pmc Macular cone abnormalities in retinitis pigmentosa with preserved central vision using adaptive optics scanning laser ophthalmoscopy
    Yukiko Makiyama
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
    PLoS ONE 8:e79447. 2013
    To assess macular photoreceptor abnormalities in eyes with retinitis pigmentosa (RP) with preserved central vision using adaptive optics scanning laser ophthalmoscopy (AO-SLO).
  74. ncbi Combined confocal scanning laser ophthalmoscopy and spectral-domain optical coherence tomography imaging of reticular drusen associated with age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology and Grade Reading Center, University of Bonn, Bonn, Germany
    Ophthalmology 117:1169-76. 2010
    ..To determine microstructural retinal alterations associated with reticular drusen in patients with age-related macular degeneration (AMD) using high-resolution in vivo imaging techniques...
  75. pmc Objective assessment of foveal cone loss ratio in surgically closed macular holes using adaptive optics scanning laser ophthalmoscopy
    Satoshi Yokota
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 8:e63786. 2013
    To use adaptive optics scanning laser ophthalmoscopy (AO-SLO) to quantify cone loss ratio in the foveola in order to assess foveal cone status and to investigate relationships between foveal structural abnormalities and visual function in ..
  76. ncbi Scanning laser ophthalmoscopy-based evaluation of epipapillary velocities: method and physiologic variability
    O Arend
    Department of Ophthalmology, Medical Faculty, Technical University of Aachen, Germany
    Surv Ophthalmol 44:S3-9. 1999
    Scanning laser ophthalmoscopy is capable of producing high-resolution fluorescein angiograms. Measurements of capillary blood velocities in the fovea are well established...
  77. ncbi Choroidal thickness in open-angle glaucoma measured by spectral-domain scanning laser ophthalmoscopy/optical coherence tomography
    Gilda Cennamo
    Eye Department, University of Naples Federico II, Naples, Italy xgilda hotmail com
    Ophthalmologica 228:47-52. 2012
    To measure macular choroidal thickness in healthy and glaucomatous eyes using spectral-domain scanning laser ophthalmoscopy/optical coherence tomography.
  78. ncbi Asymptomatic optic neuropathy associated with Churg-Strauss syndrome
    Brett J Rosenblatt
    Neuro Ophthalmology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 110:1650-2. 2003
    ..To report asymptomatic optic disc edema in a patient with Churg-Strauss syndrome...
  79. ncbi In vivo imaging and quantitative evaluation of the rat retinal nerve fiber layer using scanning laser ophthalmoscopy
    Ichiro Kawaguchi
    Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Invest Ophthalmol Vis Sci 47:2911-6. 2006
    To determine whether scanning laser ophthalmoscopy (SLO) is useful for in vivo imaging and quantitative evaluation of rat retinal nerve fiber layer (RNFL) using an optic nerve crush model.
  80. ncbi Further characterization of ocular safety profile of commercially available preserved and preservative-free triamcinolone acetonide
    Yuli Li
    Institute of Ocular Pharmacology, School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang, China
    Retina 32:364-74. 2012
    ..To characterize the safety profile of triamcinolone acetonide (TA) for intraocular application...
  81. pmc Wavefront sensorless adaptive optics ophthalmoscopy in the human eye
    Heidi Hofer
    College of Optometry, University of Houston, Houston Texas 77204, USA
    Opt Express 19:14160-71. 2011
    ..Wavefront sensorless control is a viable option for imaging the living human eye and future refinements of this technique may result in even greater optical gains...
  82. ncbi Digital simultaneous fluorescein and indocyanine green angiography, autofluorescence, and red-free imaging with a solid-state laser-based confocal scanning laser ophthalmoscope
    Jork J Jorzik
    Department of Ophthalmology, University of Heidelberg, Germany
    Retina 25:405-16. 2005
    ..To describe and to evaluate a novel confocal scanning laser ophthalmoscope (cSLO) for fluorescence angiography, fundus autofluorescence (FAF), and red-free imaging...
  83. ncbi Does direct ophthalmoscopy improve retinal screening for diabetic eye disease by retinal photography?
    G P Leese
    Ninewells Hospital, Dundee, UK
    Diabet Med 19:867-9. 2002
    To identify whether after performing retinal photography, direct ophthalmoscopy can improve the yield of screening for the detection of sight-threatening diabetic eye disease (STDED).
  84. ncbi Impact of retinopathy of prematurity screening examination on cardiorespiratory indices: a comparison of indirect ophthalmoscopy and retcam imaging
    Achyut N Mukherjee
    Department of Ophthalmology, University Hospital of Wales, Cardiff, United Kingdom
    Ophthalmology 113:1547-52. 2006
    To compare the impact of retinopathy of prematurity (ROP) screening examination between a digital fundus camera and conventional binocular indirect ophthalmoscopy (BIO) using cardiorespiratory indices as a measure of distress.
  85. ncbi Cystoid macular edema in polypoidal choroidal vasculopathy viewed by a scanning laser ophthalmoscope: CME in PCV viewed by SLO
    Motoshi Yamamoto
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    Int Ophthalmol 29:503-6. 2009
    ..SLO in the retro-mode can show each cystoid space located in any layer of the retina, and allows us to detect the extent of the CME...
  86. ncbi Scanning laser polarimetry and confocal scanning laser ophthalmoscopy: technical notes on their use in glaucoma
    Felicia Ferreri
    Section of Ophthalmology, Department of Surgical Specialties, Azienda Ospedaliera Universitaria Policlinico G Martino, Messina, Italy
    Prog Brain Res 173:125-38. 2008
    ..The correct evaluation of the parameters studied by these techniques and the knowledge of the instruments' limits are needed for an adequate interpretation of the results obtained...
  87. ncbi Clinical evaluation of simultaneous confocal scanning laser ophthalmoscopy imaging combined with high-resolution, spectral-domain optical coherence tomography
    Hans Martin Helb
    Department of Ophthalmology, University of Bonn, Germany
    Acta Ophthalmol 88:842-9. 2010
    To evaluate the clinical relevance of a new diagnostic modality, simultaneous confocal scanning laser ophthalmoscopy (cSLO) and high-speed, high-resolution, spectral-domain optical coherence tomography (OCT), for the visualization of ..
  88. ncbi Longitudinal evaluation of optic disc measurement variability with optical coherence tomography and confocal scanning laser ophthalmoscopy
    Dusheng Lin
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PR China
    J Glaucoma 18:101-6. 2009
    To evaluate and compare the longitudinal variability of optical coherence tomography (OCT) and confocal scanning laser ophthalmoscopy (CSLO) optic disc measurements.
  89. ncbi In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography
    Barry Cense
    Wellman Laboratories of Photomedicine, Harvard Medical School and Massachusetts General Hospital, 50 Blossom Street BAR 714, Boston, MA 02114, USA
    J Biomed Opt 9:121-5. 2004
    ..A trend in the preliminary measurements shows that the nerve fiber layer located inferior and superior to the optic nerve head is more birefringent than the thinner layer of nerve fiber tissue in the temporal and nasal regions...
  90. ncbi Scanning laser ophthalmoscopy and angiography with a wide-field contact lens system
    Giovanni Staurenghi
    University Eye Clinic, University of Brescia, Brescia, Italy
    Arch Ophthalmol 123:244-52. 2005
    ..To perform fluorescein and indocyanine green angiography for large or peripheral chorioretinal structures using a contact lens system that provides a 5-fold increase in the field of view of a confocal scanning laser ophthalmoscope (SLO)...
  91. ncbi Visualization of subthreshold micropulse diode laser photocoagulation by scanning laser ophthalmoscopy in the retro mode
    Kishiko Ohkoshi
    Department of Ophthalmology, St Luke s International Hospital, Tokyo, Japan
    Am J Ophthalmol 150:856-62. 2010
    To assess the efficacy of scanning laser ophthalmoscopy in the retro mode, employing a new dark-field aperture, for detecting laser spots created by subthreshold diode laser micropulse photocoagulation.
  92. ncbi Combined en-face optical coherence tomography and confocal ophthalmoscopy findings in active multifocal and serpiginous chorioretinitis
    Mirjam E J van Velthoven
    Department of Ophthalmology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Am J Ophthalmol 141:972-5. 2006
    ..To describe retinal changes in active multifocal and serpiginous chorioretinitis seen with en-face optical coherence tomography (OCT)...
  93. ncbi [Quantification of retinal nerve fiber thickness. A comparison of laser scanning ophthalmoscopy, polarimetry and optical coherence tomography in healthy and glaucomatous eyes]
    M Klemm

    Ophthalmologe 98:832-43. 2001
    ....
  94. ncbi In vivo imaging of lamina cribrosa pores by adaptive optics scanning laser ophthalmoscopy
    Tadamichi Akagi
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 53:4111-9. 2012
    To visualize and assess the surface-level pores of the lamina cribrosa in patients with glaucoma by using a prototype adaptive optics scanning laser ophthalmoscopy (AOSLO) system.
  95. ncbi Computer-assisted assessment of plus disease in retinopathy of prematurity using video indirect ophthalmoscopy images
    Sukaina Ahmad
    Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA
    Retina 28:1458-62. 2008
    ROPtool" is a computer program that measures retinal blood vessel tortuosity. Our aim was to determine the feasibility and accuracy of analyzing images with ROPtool, which were obtained using video indirect ophthalmoscopy.
  96. pmc Blue on yellow perimetry with scanning laser ophthalmoscopy in patients with age related macular disease
    A Remky
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Br J Ophthalmol 89:464-9. 2005
    ..A case-control study of patients with ARM and age matched controls was performed, using blue on yellow static perimetry...
  97. ncbi A pilot study to detect glaucoma with confocal scanning laser ophthalmoscopy compared with nonmydriatic stereoscopic photography in a community health screening
    Shinji Ohkubo
    Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Glaucoma 16:531-8. 2007
    ..To assess the efficacy and practical usefulness of the Heidelberg Retina Tomograph II (HRT II) compared with nonmydriatic stereoscopic photography in a public glaucoma screening...
  98. ncbi Optical coherence tomography/scanning laser ophthalmoscopy imaging of optic nerve head drusen
    Nandesh N Patel
    The New York Eye Cancer Center, New York, NY, USA
    Ophthalmic Surg Lasers Imaging 41:614-21. 2010
    To evaluate optical coherence tomography/scanning laser ophthalmoscopy (OCT/SLO) imaging for optic nerve head drusen (ONHD).
  99. ncbi Screening for retinopathy of prematurity--a comparison between binocular indirect ophthalmoscopy and RetCam 120
    Parag K Shah
    Vitreo Retinal Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, India
    Indian J Ophthalmol 54:35-8. 2006
    ..To compare the photographic screening for retinopathy of prematurity (ROP) using RetCam 120 with binocular indirect ophthalmoscope (BIO), which is the current gold standard...
  100. ncbi Hyperreflective sign in resolved cotton wool spots using high-resolution optical coherence tomography and optical coherence tomography ophthalmoscopy
    Igor Kozak
    Jacobs Retina Center, Shiley Eye Center, University of California San Diego, La Jolla, California 92037, USA
    Ophthalmology 114:537-43. 2007
    ..To characterize retinal changes in areas of cotton wool spots (CWSs) using optical coherence tomography (OCT) and to determine the optical density changes of the retina after CWSs have disappeared clinically...
  101. ncbi Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography a study on diagnostic agreement with Heidelberg Retinal Tomograph
    Christopher Kai Shun Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PR China
    Ophthalmology 117:267-74. 2010
    ..To evaluate and compare the diagnostic agreement and performance for glaucoma detection between a confocal scanning laser ophthalmoscope and a spectral-domain optical coherence tomograph (OCT)...

Research Grants62

  1. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..first address the need for technology by developing multimodal technologies based on functional photoacoustic ophthalmoscopy (PAOM), optical coherence tomography (OCT)/optical Doppler tomography (ODT)...
  2. Transgenic Mitomice Models for Treatment of Blinding Diseases
    John Guy; Fiscal Year: 2013
    ..mCherry) to the MTS AAV construct containing mutant human ND4 that could be visualized by laser scanning ophthalmoscopy (LSO) in live offspring and so far in three generations of their progeny...
  3. Genetics and Functional Studies of Age-Related Macular Degeneration
    Kang Zhang; Fiscal Year: 2012
    ..Pathology will be examined in the conditional knockout (KO) by ophthalmoscopy, histology, ERG, and HTRA1 expression will be determined by QPCR, western blot and immunohistochemistry (IHC)...
  4. Compartmentalized neurodegeneration of retinal ganglion cells in glaucoma
    Yvonne Ou; Fiscal Year: 2013
    ..Aim 2 will examine dendrite morphology longitudinally using confocal laser scanning ophthalmoscopy to image the retinas of live CB2-GFP mice, in which a subset of relatively large transient OFF-aRGCs are ..
  5. High Performance Multimodal Adaptive Optics Retinal Imaging
    R Daniel Ferguson; Fiscal Year: 2011
    ..represents the first ever high performance AO system constructed that combines AO- corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact ..
  6. Adaptive Optics Instrumentation for Advanced Ophthalmic Imaging
    David R Williams; Fiscal Year: 2012
    ..Other lead investigators include: Steve Burns (Indiana University) an international leader in laser scanning ophthalmoscopy, John Flannery (UC, Berkeley) an expert in retinal degeneration and the development of retinal biomarkers, and ..
  7. Phase 2 Study of CNTF on Photoreceptor Structure in Retinitis Pigmentosa
    JACQUE LYNNE DUNCAN; Fiscal Year: 2012
    ..However, adaptive optics scanning laser ophthalmoscopy (AOSLO) can produce images of individual cone photoreceptors in eyes with retinal degeneration...
  8. Handheld Ocular Flare Meter Clinical Study
    NARESH MENON; Fiscal Year: 2012
    ..methods of diagnosis for uveitis involve a thorough examination of the eye with a slit lamp microscope and ophthalmoscopy. Higher levels of flare in particular have been associated with poor visual outcomes in patients with certain ..
  9. Near Infrared Detector for Advanced Ophthalmology
    Richard Myers; Fiscal Year: 2013
    ..In particular, scanning laser ophthalmoscopy has proven to be an important technique for studies of microperimetry, psychophysics and visual neuroscience ..
  10. P30 - CORE GRANT FOR VISION RESEARCH
    P Michael Iuvone; Fiscal Year: 2013
    ..Proteomics module adds new capabilities for visual phenotyping of rodents, including SD-OCT, scanning laser ophthalmoscopy, partial coherence interferometry, high precision micrometry, photorefraction, gonioscopy, rebound tonometry, ..
  11. Models for Vision Research
    Patsy M Nishina; Fiscal Year: 2013
    ..In the present application, we will screen ~10,000 mutagenized G3 Crumbs1rd8/rd8 mice by indirect ophthalmoscopy to identify mutants that present with an altered Crumbs1drd8 fundus phenotype...
  12. PHOTORECEPTOR FUNCTION IN RETINOPATHY OF PREMATURITY
    Anne B Fulton; Fiscal Year: 2013
    ..coherence tomography (AO-OCT), and extrafoveal cone packing geometry will be studied using scanning laser ophthalmoscopy (AO-SLO)...
  13. Diagnostic Innovations in Glaucoma: Structural Assessment
    Linda M Zangwill; Fiscal Year: 2013
    ..Longitudinal monkey and human spectral domain optical coherence tomography (SDOCT), confocal scanning laser ophthalmoscopy (CSLO) and scanning laser polarimetry (GDx) data and images will be used to address the following 3 specific ..
  14. Telemedicine Approaches to Evaluating Acute-phase ROP - eROP
    Graham E Quinn; Fiscal Year: 2013
    ..agreement for deciding whether digital images indicate that the eye are in need of diagnostic indirect ophthalmoscopy by ophthalmologist experienced In ROP (reliability); 3...
  15. Adaptive optics parallel confocal scanning ophthalmoscope (AO-PCSO)
    YUHUA LIANG ZHANG; Fiscal Year: 2012
    ..The cellular scale retinal image in the living human eye can only be achieved by adaptive optics (AO) assisted ophthalmoscopy. But current AO retinal imaging is hampered by insufficient image acquisition speed and inadequate image ..
  16. Multimode Adaptive Optics Retinal Imager for Diagnosis of Age-Related Macular Deg
    Daniel Hammer; Fiscal Year: 2009
    ..will integrate AO, swept-source based Fourier domain optical coherence tomography (FDOCT), and scanning laser ophthalmoscopy (SLO). It will also include many clinical enhancements including retinal tracking for stabilized imaging...
  17. Adaptive optics imaging of geographic atrophy progression in macular degeneration
    MINA MILLICENT CHUNG; Fiscal Year: 2013
    ..Advances in retinal imaging with fluorescence adaptive optics scanning laser ophthalmoscopy (FAOSLO) have for the first time enabled the identification of individual cones, rods, and RPE cells ..
  18. Novel Mouse Models of Age-Related Macular Degeneration
    Jayakrishna Ambati; Fiscal Year: 2007
    ..Specific Aims: (1) To quantify the development of AMD-like features in CCL2-/- or CCR2-/- mice by ophthalmoscopy, angiography, and histopathology, compared to age-matched wild-type mice...
  19. OHTS and EGPS: Glaucoma detection using Confocal Scanning Laser Ophthalmology
    Linda Zangwill; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The overall goal of this study is to pool confocal scanning laser ophthalmoscopy (CSLO) data from two large randomized trials, the Ocular Hypertension Treatment Study (OHTS) and the European Glaucoma ..
  20. TOXOCARA CANIS INFECTION OF THE PRIMATE EYE
    ROBERT WATZKE; Fiscal Year: 1980
    ..eyes of primates so exposed are evaluated by periodic ocular examination by slit-lamp biomicroscopy, indirect ophthalmoscopy and contact lens slit-lamp biomicroscopy...
  21. EXPERIMENTAL OCULAR VASCULAR OCCLUSIVE STUDIES
    SOHAN HAYREH; Fiscal Year: 1992
    ..Goldblatt's procedure The animals are being investigated serially by a detailed ocular examination (including ophthalmoscopy, color fundus photography, and fluorescein fundus angiography) as well as systemic evaluation (by recording ..
  22. HAND HELD DIGITAL OPHTHALMOSCOPE
    RICHARD DESLAURIERS; Fiscal Year: 1999
    ..All hand-held ophthalmoscopes that are used today use the principles of either direct ophthalmoscopy or indirect ophthalmoscopy...
  23. QUANTITATIVE ANALYSIS OF OPTIC DISC/OCULAR HYPERTENSION
    Robert Weinreb; Fiscal Year: 2009
    ..describes a competitive renewal for an additional five years of funding for the confocal scanning laser ophthalmoscopy (CSLO) ancillary study to the Ocular Hypertension Treatment Study (OHTS)...
  24. A LONGITUDINAL STUDY OF HYPERTENSIVE RETINOPATHY
    Lee Jampol; Fiscal Year: 1980
    ..Vitreous fluorophotometry is also being performed on some patients and, in the future, a television ophthalmoscopy system will be used to record retinal blood flow rates, transit times and oximetry data on hypertensive ..
  25. Optical Imaging of Retinal Blood Circulation
    LEONARD WINCHESTER; Fiscal Year: 2005
    ..the ability to evaluate multi-system diseases without invasive diagnostic testing, using direct and indirect ophthalmoscopy, and slit lamp biomicroscope examination...
  26. DIABETIC RETINOPATHY EDUCATION STUDY II
    Lawrence Chong; Fiscal Year: 1992
    ..3. Independent study materials issued at 0 months and direct ophthalmoscopy on model eyes at 0 months. 4...
  27. STUDY OF ULTRASONICALLY INDUCED OCULAR DAMAGE
    ERNEST FELEPPA; Fiscal Year: 1990
    ..The effect of intense ultrasound on tissues will be studied by indirect ophthalmoscopy, fundus photography and diagnostic ultrasonography, and histologically by light, electron, and acoustic ..
  28. Optical Imaging of Retinal Blood Circulation
    LEONARD WINCHESTER; Fiscal Year: 2001
    ..Standard techniques to clinically evaluate retinal vasculature in humans-direct and indirect ophthalmoscopy, as well as slit lamp examination-do not directly measure retinal blood flow, an assessment that may be ..
  29. Telemedical Diagnosis of Retinopathy of Prematurity
    Michael Chiang; Fiscal Year: 2007
    ..Columbia University has a strong existing framework in medical information systems, telemedicine, and public health, which will be leveraged to complete this training and research program successfully. ..
  30. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  31. Diagnostic Innovations in Glaucoma: Clinical Electrophysiology
    Christopher Bowd; Fiscal Year: 2008
    ..including optical imaging of the optic disc and retinal nerve fiber layer (RNFL) (confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry) and visual function-specific perimetry (short-..
  32. Female Hormones and Vision
    Alvin Eisner; Fiscal Year: 2006
    ..abstract_text> ..
  33. Quan11tification of Glaucomatous Optic Neuropathy
    Christopher Girkin; Fiscal Year: 2006
    ....
  34. OCULAR MELANOMA
    Dennis Robertson; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed; and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  35. Low-Cost Device for Digital Retinal Imaging
    ANN ELSNER; Fiscal Year: 2007
    ..We will investigate the key features considered necessary for early detection grading, and also more the serious damage that is typically discovered late in the rural and urban underserved. ..
  36. ADAPTIVE OPTICS SCANNING LASER OPHTHALMOSCOPE
    Austin Roorda; Fiscal Year: 2003
    ..This SLO design has the potential to greatly decrease the effects of scattered light and further increase the resolution of fundus imaging. ..
  37. Retinal Microvascular Signs and CVD in Older Persons
    Tien Wong; Fiscal Year: 2005
    ..This may ultimately lead to improved identification, and preventive and therapeutic strategies for the most common causes of morbidity, disability and mortality affecting elderly people in the United States. ..
  38. VISUAL ADAPTATION LIMITS AND AGE-RELATED DISEASE
    Alvin Eisner; Fiscal Year: 2002
    ....
  39. Organization of the Trichromatic Cone Mosaic
    Joseph Carroll; Fiscal Year: 2005
    ..This will be done in subjects for whom we also have a representation of their cone mosaic, to be able to selectively stimulate cones from a particular class. ..
  40. Low-Cost Device for Digital Retinal Imaging
    Ann E Elsner; Fiscal Year: 2010
    ..While this project focuses on diabetic retinopathy in humans, future applications include other retinal disorders in both humans and animal models. ..
  41. PIGMENT EPITHELIUM REMOVAL AND TRANSPLANTATION
    Marco Zarbin; Fiscal Year: 2003
    ..IV: Assess long-term viability of syngeneic RPE sheet transplants onto damaged Bruch's membrane using a published in vivo RPE debridement model. ..
  42. Retinal Tracking for Enhances OCT Imaging
    R Ferguson; Fiscal Year: 2004
    ..Adjacent 2-D scans can be concatenated into 3-D data sets. Standard resolution and high resolution TOCT systems will be assembled and tested in clinical studies at New England Eye Center. ..
  43. Enhancing Cell Survival on Aged Bruch's Membrane
    Marco Zarbin; Fiscal Year: 2007
    ..abstract_text> ..
  44. TAILORED COMMUNICATIONS FOR COLORECTAL CANCER SCREENING
    CHARLES BASCH; Fiscal Year: 2003
    ..This proposal addresses the need for research assessing tailored communications to increase CRC screening in minority groups. ..
  45. GLAUCOMA SURGICAL OUTCOMES STUDY
    Henry Jampel; Fiscal Year: 2001
    ..The results of the study may allow physicians to reduce the morbidity of glaucoma surgery by altering their indications for surgery, surgical technique, and postoperative follow-up. ..
  46. EARLY DETECTION OF GLAUCOMA DAMAGE
    Henry Jampel; Fiscal Year: 2004
    ..This assessment of the RTA and NFA will help to establish their utility as outcome measures for clinical management of glaucoma, epidemiological research, and clinical trials. ..
  47. Stabilized Adaptive Optics Imaging Laser Microsurgery
    Daniel Hammer; Fiscal Year: 2004
    ..The diagnostic instrument will use scanning laser ophthalmoscopy (SLO) at its core, with unique and necessary enhancements of adaptive optics and retinal tracking used to ..
  48. Building a New Model for Diagnosis of ED Dizzy Patients
    David Newman Toker; Fiscal Year: 2007
    ..This research project and the research paradigms derived from it will form the nucleus of a career devoted to research in medical decision-making, causes of diagnostic errors, and methods to preventthem. ..
  49. OCULAR DEVELOPMENT IN INFANCY/EARLY CHILDHOOD
    Donald Mutti; Fiscal Year: 2005
    ..abstract_text> ..
  50. A Critical Role for SHP-1 in Retinal Degeneration
    Bonnie Lyons; Fiscal Year: 2006
    ..Such determinations will test the hypothesis that SHP- 1 is a critical signaling molecule necessary for the normal phagocytic function of the RPE. ..
  51. RETINAL NERVE FIBER LAYER REFLECTANCE MECHANISMS
    Xiangrun Huang; Fiscal Year: 2007
    ..Birefringence is an intrinsic property of the tissue, depends directly on RNFL ultrastructure, and may provide a means of early detection of structural damage to ganglion cells in glaucoma. ..
  52. Compact Line-scanning Adaptive Optics Retinal Imager
    Daniel Hammer; Fiscal Year: 2007
    ..These researchers will, in turn, use this tool to increase our understanding of vision and its disruption by disease and for the development of new drugs and therapies. [unreadable] [unreadable] [unreadable]..
  53. Eicosanoids and the Outflow Pathways of the Eye
    Robert Weinreb; Fiscal Year: 2008
    ..The results of these studies have important implications for the discovery of new treatments for glaucoma and other vision-threatening eye diseases. ..
  54. The Predictive Value of Pre-plus Disease in ROP
    David Wallace; Fiscal Year: 2008
    ..grade the degree of vascular dilation and tortuosity in digital retinal images generated from video indirect ophthalmoscopy in a cohort of 150 infants...
  55. Evaluating Alternative Retinopathy Screening Approaches
    CHARLES BASCH; Fiscal Year: 2008
    ..These interventions are practical, have potential for widespread dissemination, and can translate basic and clinical research to achieve public health benefits. ..
  56. Outcome Measures in Idiopathic Intracranial Hypertension
    Deborah Friedman; Fiscal Year: 2008
    ..Acquire the training, mentoring and experience necessary to conduct independent, funded clinical research in ophthalmologic and neurological disorders Obtain a Masters Degree in Public Health/Clinical Investigator track ..
  57. Retinal Hemodynamic Imaging with Tracking Doppler Flowmetry
    R Ferguson; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  58. Caloric Restriction and Aging in Eyes
    Peter Gouras; Fiscal Year: 2010
    ..Because many of these primates are near the end of their lifespan, there is an element of urgency in our goal to correlate noninvasive clinical testing prior with post mortem histology. ..
  59. Single Shot OCT
    Daniel Hammer; Fiscal Year: 2006
    ..In addition, the developed instrument and the principles upon which it is based may be used to image other disease types throughout the human body. [unreadable] [unreadable] [unreadable]..