fluorescein angiography

Summary

Summary: Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.

Top Publications

  1. doi Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study
    David M Brown
    Retinal Consultants of Houston, Houston, Texas, USA
    Ophthalmology 118:1594-602. 2011
  2. doi Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: the EXCITE study
    Ursula Schmidt-Erfurth
    Department of Ophthalmology, University of Vienna, Waehringer Guertel, Vienna, Austria
    Ophthalmology 118:831-9. 2011
  3. doi Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, Texas 77030, USA
    Ophthalmology 116:57-65.e5. 2009
  4. ncbi Macular perfusion determined by fundus fluorescein angiography at the 4-month time point in a prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (Bolt Study): Report 1
    Michel Michaelides
    Department of Medical Retina, Moorfields Eye Hospital, London, UK
    Retina 30:781-6. 2010
  5. ncbi Polypoidal choroidal vasculopathy: incidence, demographic features, and clinical characteristics
    Kenichiro Sho
    Department of Ophthalmology, Kansai Medical University, Fumizono cho, Moriguchi, Osaka, Japan
    Arch Ophthalmol 121:1392-6. 2003
  6. doi Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study
    Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Ophthalmology 118:663-71. 2011
  7. ncbi Aging changes of the choroidal dye filling pattern in indocyanine green angiography of normal subjects
    Y N Ito
    Department of Ophthalmology, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Retina 21:237-42. 2001
  8. ncbi Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
    Magdalena G Krzystolik
    Retina Service, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Arch Ophthalmol 120:338-46. 2002
  9. ncbi Polypoidal choroidal vasculopathy
    Antonio P Ciardella
    The LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York 10021, USA
    Surv Ophthalmol 49:25-37. 2004
  10. doi Photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: a 30-month multicenter study in Hyogo, Japan
    Shigeru Honda
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, and Department of Ophthalmology, Kobe City General Hospital, Kobe, Japan
    Jpn J Ophthalmol 53:593-7. 2009

Research Grants

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
  3. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2010
  4. Portable Retinal Imaging Device for Urgent Referrals and Remote Treatment
    Matthew S Muller; Fiscal Year: 2012
  5. Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
    Scott E Fraser; Fiscal Year: 2010
  6. Dynamic ICG and FA Software
    Timothy Holmes; Fiscal Year: 2009
  7. Regulation of vascular leakage in age related macular degeneration
    MEREDITH GREGORY-KSANDER; Fiscal Year: 2013
  8. Maureen G Maguire; Fiscal Year: 2016
  9. Qifa Zhou; Fiscal Year: 2015
  10. Ingrid U Scott; Fiscal Year: 2016

Detail Information

Publications323 found, 100 shown here

  1. doi Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study
    David M Brown
    Retinal Consultants of Houston, Houston, Texas, USA
    Ophthalmology 118:1594-602. 2011
    ..Assess 12-month efficacy and safety of intraocular injections of 0.3 mg or 0.5 mg ranibizumab in patients with macular edema after branch retinal vein occlusion (BRVO)...
  2. doi Efficacy and safety of monthly versus quarterly ranibizumab treatment in neovascular age-related macular degeneration: the EXCITE study
    Ursula Schmidt-Erfurth
    Department of Ophthalmology, University of Vienna, Waehringer Guertel, Vienna, Austria
    Ophthalmology 118:831-9. 2011
    ..To demonstrate noninferiority of a quarterly treatment regimen to a monthly regimen of ranibizumab in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD)...
  3. doi Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    David M Brown
    Vitreoretinal Consultants, Methodist Hospital, Houston, Texas 77030, USA
    Ophthalmology 116:57-65.e5. 2009
    ....
  4. ncbi Macular perfusion determined by fundus fluorescein angiography at the 4-month time point in a prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (Bolt Study): Report 1
    Michel Michaelides
    Department of Medical Retina, Moorfields Eye Hospital, London, UK
    Retina 30:781-6. 2010
    The purpose of this study was to assess macular perfusion with fundus fluorescein angiography at the 4-month time point in a prospective randomized, single-center 2-year trial comparing intravitreal bevacizumab and laser therapy in ..
  5. ncbi Polypoidal choroidal vasculopathy: incidence, demographic features, and clinical characteristics
    Kenichiro Sho
    Department of Ophthalmology, Kansai Medical University, Fumizono cho, Moriguchi, Osaka, Japan
    Arch Ophthalmol 121:1392-6. 2003
    ..To clarify the incidence, demographic features, and clinical characteristics of polypoidal choroidal vasculopathy (PCV) in Japanese patients...
  6. doi Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study
    Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Ophthalmology 118:663-71. 2011
    ..To evaluate the safety and efficacy of individualized ranibizumab treatment in patients with neovascular age-related macular degeneration...
  7. ncbi Aging changes of the choroidal dye filling pattern in indocyanine green angiography of normal subjects
    Y N Ito
    Department of Ophthalmology, Saitama Medical School, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    Retina 21:237-42. 2001
    ..To study the aging changes in the choroid of healthy volunteers with indocyanine green (ICG) angiography...
  8. ncbi Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
    Magdalena G Krzystolik
    Retina Service, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Arch Ophthalmol 120:338-46. 2002
    ....
  9. ncbi Polypoidal choroidal vasculopathy
    Antonio P Ciardella
    The LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York 10021, USA
    Surv Ophthalmol 49:25-37. 2004
    ....
  10. doi Photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy: a 30-month multicenter study in Hyogo, Japan
    Shigeru Honda
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, and Department of Ophthalmology, Kobe City General Hospital, Kobe, Japan
    Jpn J Ophthalmol 53:593-7. 2009
    ..To evaluate the long-term effects of photodynamic therapy (PDT) on different phenotypes of age-related macular degeneration (AMD): typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV)...
  11. ncbi One-year outcomes of photodynamic therapy in age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 115:141-6. 2008
    ....
  12. doi Photoreceptor outer segment abnormalities as a cause of blind spot enlargement in acute zonal occult outer retinopathy-complex diseases
    Richard F Spaide
    Vitreous Retina Macula Consultants of New York and the LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, 460 Park Avenue, New York, NY 10022, USA
    Am J Ophthalmol 146:111-20. 2008
    ..To investigate the correlation between visual field (VF) defects in diseases of the acute zonal occult outer retinopathy (AZOOR)-complex and their spectral-domain optical coherence tomographic (OCT) findings...
  13. doi Refractory neovascular age-related macular degeneration secondary to polypoidal choroidal vasculopathy
    Minhee Cho
    New York University School of Medicine Manhattan Eye, Ear and Throat Hospital, Department of Ophthalmology, New York, New York, USA
    Am J Ophthalmol 148:70-8.e1. 2009
    ..To describe a neovascular pattern associated with treatment-refractory neovascular age-related macular degeneration (AMD)...
  14. doi Results of one-year's treatment with ranibizumab for exudative age-related macular degeneration in a clinical setting
    Salomon Y Cohen
    Centre Ophtalmologique d Imagerie et de Laser, Assistance Publique Hôpitaux de Paris and Université Paris 7, France
    Am J Ophthalmol 148:409-13. 2009
    ..To evaluate the results of 1 year of treatment with intravitreal ranibizumab for exudative age-related macular degeneration (AMD) in a clinical setting...
  15. doi Ranibizumab in retinal angiomatous proliferation (RAP): influence of RAP stage on visual outcome
    Juan Reche-Frutos
    Ophthalmology Department, Hospital Clinico San Carlos, Madrid, Spain
    Eur J Ophthalmol 21:783-8. 2011
    ..To evaluate the influence of retinal angiomatous proliferation (RAP) stage on visual and anatomic outcome after ranibizumab (Lucentis®)...
  16. pmc Indocyanine green fluorescence imaging for evaluation of uterine blood flow in cynomolgus macaque
    Iori Kisu
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 7:e35124. 2012
    ..In this study, indocyanine green (ICG) fluorescence imaging was used to examine uterine hemodynamics and vessels associated with uterine blood flow in cynomolgus macaque...
  17. ncbi Ultra-wide-field fluorescein angiography of the ocular fundus
    Ayyakkannu Manivannan
    Department of Bio Medical Physics and Bio Engineering, Forresterhill, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Am J Ophthalmol 140:525-7. 2005
    To evaluate the clinical applicability of a novel scanning laser ophthalmoscopy imaging system for ultra-wide-field fluorescein angiography.
  18. ncbi Tears of the retinal pigment epithelium: an old problem in a new era
    Louis K Chang
    Jules Stein Eye Institute, Department of Ophthalmology, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 27:523-34. 2007
    ..The authors review the clinical features, etiologies, imaging characteristics, and pathogenesis of RPE tears and their relationship with intravitreal anti-VEGF treatments...
  19. ncbi Role of photodynamic therapy in polypoidal choroidal vasculopathy
    Eriko Akaza
    Department of Ophthalmology, Surugadai Hospital of Nihon University, Kanda, Tokyo, Japan
    Jpn J Ophthalmol 51:270-7. 2007
    ..To determine the efficacy of photodynamic therapy (PDT) with verteporfin for polypoidal choroidal vasculopathy (PCV)...
  20. doi Peripheral exudative hemorrhagic chorioretinopathy: a clinical, angiographic, and histologic study
    Irmela Mantel
    Ophthalmology Department, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland
    Am J Ophthalmol 148:932-8.e1. 2009
    ....
  21. doi Background comparison of typical age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients
    Takashi Ueta
    Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
    Ophthalmology 116:2400-6. 2009
    ..To compare background factors of the 2 most dominant subtypes of exudative age-related macular degeneration (AMD) in the Japanese population: typical AMD and polypoidal choroidal vasculopathy (PCV)...
  22. pmc Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse
    Kristopher G Sheets
    Department of Ophthalmology and the Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Mol Vis 16:320-9. 2010
    ..Specifically, this was assessed by clinically grading laser-induced lesions, measuring leakage area, and volumetrically quantifying vascular endothelial cell proliferation...
  23. doi Optical coherence tomographic evaluation of foveal hard exudates in patients with diabetic maculopathy accompanying macular detachment
    Masafumi Ota
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ophthalmology 117:1996-2002. 2010
    ....
  24. pmc Documentation of intraretinal retinal pigment epithelium migration via high-speed ultrahigh-resolution optical coherence tomography
    Joseph Ho
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts, USA
    Ophthalmology 118:687-93. 2011
    ....
  25. pmc Vessel boundary delineation on fundus images using graph-based approach
    Xiayu Xu
    Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
    IEEE Trans Med Imaging 30:1184-91. 2011
    ..The algorithm is robust and estimates the vessel width with subpixel accuracy. The method is used to explore the relationship between the average vessel width and the distance from the optic disc in 600 subjects...
  26. doi Three-year follow-up results of photodynamic therapy for polypoidal choroidal vasculopathy
    Eriko Akaza
    Department of Ophthalmology, Nihon University Surugadai Hospital, Tokyo, Japan
    Jpn J Ophthalmol 55:39-44. 2011
    ..To evaluate the visual outcomes and changes in abnormal vascular networks and polypoidal lesions of polypoidal choroidal vasculopathy (PCV) 3 years after photodynamic therapy (PDT)...
  27. ncbi The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy
    Felice Cardillo Piccolino
    Institute of Ophthalmology, Department of Clinical Physiopathology, University of Torino, Torino, Italy
    Am J Ophthalmol 139:87-99. 2005
    ..To describe changes of the foveal photoreceptor layer using optical coherence tomography (OCT) in central serous chorioretinopathy (CSC) and evaluate the correlation with visual acuity (VA) loss...
  28. pmc Safety enhanced photodynamic therapy with half dose verteporfin for chronic central serous chorioretinopathy: a short term pilot study
    T Y Y Lai
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong
    Br J Ophthalmol 90:869-74. 2006
    ..To evaluate short term safety of an enhanced photodynamic therapy (PDT) protocol with half dose verteporfin for treating chronic central serous chorioretinopathy (CSC)...
  29. doi Intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy for choroidal neovascularization in age-related macular degeneration
    Bradley T Smith
    Barnes Retina Institute, St Louis, Missouri, USA
    Retina 28:675-81. 2008
    ..To report the outcome for eyes treated with intravitreal injection of bevacizumab combined with verteporfin photodynamic therapy (PDT) for choroidal neovascularization (CNV) in age-related macular degeneration (AMD)...
  30. doi "Treat and extend" dosing of intravitreal antivascular endothelial growth factor therapy for type 3 neovascularization/retinal angiomatous proliferation
    Michael Engelbert
    LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY, USA
    Retina 29:1424-31. 2009
    ..The purpose of this study was to analyze long-term outcomes for the treatment of type 3 neovascularization/retinal angiomatous proliferation using a "Treat and Extend" dosing regimen for antivascular endothelial growth factor therapy...
  31. ncbi Optical coherence tomographic assessment of diabetic macular edema: comparison with fluorescein angiographic and clinical findings
    Sengul C Ozdek
    Department of Ophthalmology, Gazi University, School of Medicine, Ankara, Turkey
    Ophthalmologica 219:86-92. 2005
    ..To compare the optical coherence tomographic (OCT) features with clinical and fluorescein angiographic (FA) findings in patients with diabetic retinopathy...
  32. ncbi Histopathologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions: submacular surgery trials report no. 7
    Hans E Grossniklaus
    Montgomery Ophthalmic Pathology Labotratory, BT0428 Emory Eye Center, 1365 Clifton Road NE, Atlanta, GA 30322, USA
    Arch Ophthalmol 123:914-21. 2005
    ..To identify the histologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions from patients enrolled in the Submacular Surgery Trials and to compare them with clinical data...
  33. ncbi A fluorescein and indocyanine green angiographic study of choriocapillaris in age-related macular disease
    D Pauleikhoff
    Department of Ophthalmology, St Franziskus Hospital, Muenster, Germany
    Arch Ophthalmol 117:1353-8. 1999
    ..To examine the phenomenon of a prolonged choroidal filling phase (PCFP) as seen on fluorescein and indocyanine green (ICG) angiography in patients with early age-related macular disease (AMD)...
  34. ncbi Photodynamic therapy with verteporfin for symptomatic polypoidal choroidal vasculopathy: one-year results of a prospective case series
    Wai Man Chan
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, People s Republic of China
    Ophthalmology 111:1576-84. 2004
    ..To determine the efficacy of photodynamic therapy (PDT) with verteporfin as a treatment for symptomatic polypoidal choroidal vasculopathy (PCV)...
  35. ncbi Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular age-related macular degeneration
    U Chakravarthy
    Centre for Vision Sciences, The Queen s University of Belfast and The Royal Victoria Hospital, Belfast, United Kingdom
    Ophthalmology 113:1508.e1-25. 2006
    ..To evaluate the efficacy of a second year of pegaptanib sodium therapy in patients with neovascular age-related macular degeneration (AMD)...
  36. ncbi Bevacizumab-augmented retinal laser photocoagulation in proliferative diabetic retinopathy: a randomized double-masked clinical trial
    A Mirshahi
    Eye Research Center, Farabi Eye Hospital, Medical Sciences University of Tehran, Tehran, Iran
    Eur J Ophthalmol 18:263-9. 2008
    ..To evaluate the additional therapeutic effect of single intravitreal bevacizumab injection on standard laser treatment in the management of proliferative diabetic retinopathy...
  37. doi Primary intravitreal bevacizumab for diffuse diabetic macular edema: the Pan-American Collaborative Retina Study Group at 24 months
    J Fernando Arevalo
    Retina and Vitreous Service, Clinica Oftalmologica Centro Caracas, Caracas, Venezuela
    Ophthalmology 116:1488-97, 1497.e1. 2009
    ..San Francisco, CA; 1.25 or 2.5 mg) in patients with diffuse diabetic macular edema (DDME). In addition, a comparison of the 2 different doses of intravitreal bevacizumab (IVB) used is presented...
  38. doi Serous retinal detachment associated with retinal vein occlusion
    Akitaka Tsujikawa
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto, Japan
    Am J Ophthalmol 149:291-301.e5. 2010
    ..To study the pathomorphology of serous retinal detachment (RD) associated with retinal vein occlusion by optical coherence tomography (OCT)...
  39. doi Phenotype and genotype characteristics of age-related macular degeneration in a Japanese population
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 117:928-38. 2010
    ..To describe phenotype and genotype characteristics of age-related macular degeneration (AMD) in Japanese patients...
  40. doi Polypoidal choroidal vasculopathy masquerading as neovascular age-related macular degeneration refractory to ranibizumab
    Alexandros N Stangos
    Royal Liverpool University Hospital, United Kingdom
    Am J Ophthalmol 150:666-73. 2010
    ..To report a neovascular age-related macular degeneration pattern refractory to ranibizumab...
  41. ncbi Frequency of choroidal abnormalities in neurofibromatosis type 1
    T Yasunari
    Department of Ophthalmology, Osaka City University Medical School, Osaka, Japan
    Lancet 356:988-92. 2000
    ..We studied choroidal abnormalities in patients with neurofibromatosis 1 and compared their frequency with that of other ocular abnormalities...
  42. pmc Computer algorithms for the automated measurement of retinal arteriolar diameters
    N Chapman
    Department of Clinical Pharmacology, School of Medicine at NHLI, Imperial College of Science, Technology and Medicine, St Mary s Hospital, London W2 1NY, UK
    Br J Ophthalmol 85:74-9. 2001
    ..These problems may be overcome using computer algorithms. Three automated methods and a manual method for measurement of arteriolar diameters from digitised red-free retinal photographs were compared...
  43. ncbi Regression of neovascular age-related macular degeneration following infliximab therapy
    Nikos N Markomichelakis
    Ocular Inflammation and Immunology Service, Gennimatas Hospital, Athens University Medical School, Athens, Greece
    Am J Ophthalmol 139:537-40. 2005
    ..To describe the effects of the antitumor necrosis factor (TNF) monoclonal antibody Infliximab systemic therapy on choroidal neovacularisation (CNV) secondary to age-related macular degeneration (AMD)...
  44. ncbi Factors predictive of tumor growth, tumor decalcification, choroidal neovascularization, and visual outcome in 74 eyes with choroidal osteoma
    Carol L Shields
    Ocular Oncology Service, Wills Eye Hospital, Philadelphia, PA 19107, USA
    Arch Ophthalmol 123:1658-66. 2005
    ..To evaluate choroidal osteoma for tumor growth, tumor decalcification, related choroidal neovascularization, visual acuity loss, and poor visual acuity...
  45. doi Pars plana vitrectomy with internal limiting membrane peeling for diabetic macular edema
    Kristen L Hartley
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Florida, USA
    Retina 28:410-9. 2008
    ..To evaluate anatomic and visual acuity (VA) results of pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for diffuse diabetic macular edema (DME), and to review the literature on the topic...
  46. pmc Triple therapy for neovascular age-related macular degeneration using single-session photodynamic therapy combined with intravitreal bevacizumab and triamcinolone
    P P Yip
    Department of Ophthalmology, Tuen Mun Hosptial, Tsing Chung Koon Road, Tuen Mun, Hong Kong
    Br J Ophthalmol 93:754-8. 2009
    ..25 mg of IVB was given at 3 months for residual leakage. Best-corrected Snellen visual acuity (BCVA) and fluorescein angiography (FA) were performed prior to treatment...
  47. doi Intravitreal ranibizumab may induce retinal arteriolar vasoconstriction in patients with neovascular age-related macular degeneration
    Domniki N Papadopoulou
    Vitreo Retinal Unit, Department of Ophthalmology, 22 rue Alcide Jentzer, Geneva, Switzerland
    Ophthalmology 116:1755-61. 2009
    ..To study the effect of intravitreal (IVT) ranibizumab (Lucentis; Genentech, Inc, San Francisco, CA) on the retinal arteriolar diameter in patients with neovascular age-related macular degeneration (AMD)...
  48. ncbi A long-term follow-up study of severe variant of central serous chorioretinopathy
    Sanae Otsuka
    Department of Ophthalmology, Kagoshima University Faculty of Medicine, Kagoshima shi, Japan
    Retina 22:25-32. 2002
    ..To facilitate understanding of the long-term course and visual outcome of a severe variant of central serous chorioretinopathy...
  49. ncbi Retinal atrophy in idiopathic central serous chorioretinopathy
    Maria S M Wang
    Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Am J Ophthalmol 133:787-93. 2002
    ..To study retinal atrophy in idiopathic central serous chorioretinopathy (ICSC)...
  50. ncbi Verteporfin photodynamic therapy in the rat model of choroidal neovascularization: angiographic and histologic characterization
    David N Zacks
    Retina Service and Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 43:2384-91. 2002
    ..To develop a model of verteporfin photodynamic therapy (PDT) for experimental choroidal neovascularization CNV in the rat...
  51. ncbi Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography
    Wolfgang Drexler
    Department of Medical Physics, University of Vienna, Christian Doppler Laboratory, Austria
    Arch Ophthalmol 121:695-706. 2003
    ....
  52. doi Enhanced depth imaging spectral-domain optical coherence tomography
    Richard F Spaide
    Vitreous Retina Macula Consultants of New York, LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 146:496-500. 2008
    ..To describe a method to obtain images of the choroid using conventional spectral-domain (SD) optical coherence tomography (OCT) and to evaluate choroidal thickness measurements using these images...
  53. doi CFH and ARMS2 variations in age-related macular degeneration, polypoidal choroidal vasculopathy, and retinal angiomatous proliferation
    Hisako Hayashi
    Department of Ophthalmology and Visual Sciences, Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 51:5914-9. 2010
    ....
  54. ncbi An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    Anne E Fung
    Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
    Am J Ophthalmol 143:566-83. 2007
    ..To evaluate an optical coherence tomography (OCT)-guided, variable-dosing regimen with intravitreal ranibizumab for the treatment of patients with neovascular age-related macular degeneration (AMD)...
  55. pmc Clinicopathological correlation of polypoidal choroidal vasculopathy revealed by ultrastructural study
    A Okubo
    Department of Ophthalmology, Kagoshima University Faculty of Medicine, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Br J Ophthalmol 86:1093-8. 2002
    ..To describe the clinical and histopathological findings in a patient with polypoidal choroidal vasculopathy...
  56. ncbi Patterns of macular edema in patients with uveitis: qualitative and quantitative assessment using optical coherence tomography
    Nikos N Markomichelakis
    Ocular Immunology and Inflammation Service, Department of Ophthalmology General Hospital of Athens, Athens, Greece
    Ophthalmology 111:946-53. 2004
    ..To describe the morphologic characteristics of uveitic macular edema by the use of optical coherence tomography (OCT) and to investigate the correlation between tomographic features and visual acuity (VA)...
  57. ncbi Polypoidal choroidal vasculopathy in elderly Chinese patients
    Feng Wen
    Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, 510060 Guangzhou, PR China
    Graefes Arch Clin Exp Ophthalmol 242:625-9. 2004
    ..To investigate the frequency and clinical features of polypoidal choroidal vasculopathy (PCV) in a consecutive series of elderly Chinese patients...
  58. doi Evaluation of CXCR4 inhibition in the prevention and intervention model of laser-induced choroidal neovascularization
    Edwin Lee
    Department of Ocular Biology, Pfizer, Inc, San Diego, California, USA
    Invest Ophthalmol Vis Sci 51:3666-72. 2010
    ..Leakage was assessed by fluorescein angiography, and CNV lesion size was quantified after isolectin B4 endothelial cell staining...
  59. pmc Ketorolac inhibits choroidal neovascularization by suppression of retinal VEGF
    Stephen J Kim
    Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
    Exp Eye Res 91:537-43. 2010
    ..4% or artificial tears four times daily until sacrifice. Fluorescein angiography (FA) was performed at 2 and 3 weeks and retinal pigment epithelium-choroid-sclera flat mounts were ..
  60. ncbi Optical coherence tomography of branch retinal vein occlusion
    Richard F Spaide
    Vitreous Retina Macula Consultants of New York and the LuEsther T Mertz Retina Research Laboratory, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10021, USA
    Retina 23:343-7. 2003
    ..To evaluate the incidence of serous retinal detachment (SRD) secondary to a branch retinal vein occlusion (BRVO) by using optical coherence tomography (OCT)...
  61. ncbi Polypoidal choroidal vasculopathy: natural history
    Masanobu Uyama
    Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan
    Am J Ophthalmol 133:639-48. 2002
    ..The present study was performed to clarify the long-term natural history of polypoidal choroidal vasculopathy (PCV)...
  62. ncbi Indocyanine green angiography-guided photodynamic therapy for treatment of chronic central serous chorioretinopathy: a pilot study
    Lawrence A Yannuzzi
    LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10021, USA
    Retina 23:288-98. 2003
    ..A small percentage of patients develop chronic or progressive disease with widespread decompensation of the retinal pigment epithelium and severe vision loss. There is no known treatment for this variant of the disorder...
  63. doi Long-term effect of intravitreal bevacizumab (avastin) in patients with chronic diffuse diabetic macular edema
    Daniel Kook
    From the Department of Ophthalmology, Ludwig Maximilians Universitat, Munich, Germany
    Retina 28:1053-60. 2008
    ..To evaluate the long-term efficacy of bevacizumab for the treatment of chronic diffuse diabetic macular edema after various previous treatments...
  64. ncbi Intravitreal bevacizumab (Avastin) in the treatment of macular edema secondary to branch retinal vein occlusion
    Melvin D Rabena
    California Retina Consultants and Research Foundation, Santa Barbara, CA 93103, USA
    Retina 27:419-25. 2007
    ..To report the authors' experience after intravitreal bevacizumab (Avastin, Genentech) injection in patients with macular edema (ME) secondary to branch retinal vein occlusive disease (BRVO)...
  65. pmc Perfusion abnormalities in children with cerebral malaria and malarial retinopathy
    Nicholas A V Beare
    St Paul s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, United Kingdom
    J Infect Dis 199:263-71. 2009
    ..We aimed to examine retinal perfusion in children with CM by use of fluorescein angiography to investigate the pathophysiology of CM.
  66. ncbi Polypoidal choroidal vasculopathy with choroidal vascular hyperpermeability
    Manabu Sasahara
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Ophthalmol 142:601-7. 2006
    ..To describe the incidence and clinical characteristics of polypoidal choroidal vasculopathy (PCV) associated with choroidal vascular hyperpermeability...
  67. ncbi Segmentation of blood vessels from red-free and fluorescein retinal images
    M Elena Martinez-Perez
    Department of Computer Science, Institute of Research in Applied Mathematics and Systems, UNAM, Apdo Postal 20 726, Mexico, DF 01000, Mexico
    Med Image Anal 11:47-61. 2007
    ..Our results demonstrated that borders found by our method are less biased and follow more consistently the border of the vessel and therefore they yield more confident geometric values...
  68. doi High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 49:4137-44. 2008
    ..To describe morphologic variations in outer retinal layers in eyes with atrophic age-related macular degeneration (AMD) using high-resolution, spectral-domain optical coherence tomography (SD-OCT)...
  69. doi A classification system for polypoidal choroidal vasculopathy
    Peter Cackett
    Singapore Eye Research Institute, Singapore
    Retina 29:187-91. 2009
    ..To describe the demographic features and clinical characteristics of polypoidal choroidal vasculopathy (PCV) in Chinese patients and define a new classification system...
  70. doi Correlation of high-definition optical coherence tomography and fluorescein angiography imaging in neovascular macular degeneration
    Panagiotis Malamos
    Department of Ophthalmology, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria
    Invest Ophthalmol Vis Sci 50:4926-33. 2009
    ..the morphologic characteristics of choroidal neovascular lesions (CNV) in age-related macular degeneration (AMD) using raster scanning high-definition optical coherence tomography (HD-OCT) and conventional fluorescein angiography (FA).
  71. doi Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction
    Aparna Ramasubramanian
    Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Br J Ophthalmol 96:356-9. 2012
    ..To evaluate the effect of supplemental intravitreal bevacizumab for management of Coats' disease...
  72. doi Polypoidal choroidal vasculopathy: simultaneous indocyanine green angiography and eye-tracked spectral domain optical coherence tomography findings
    Samira Khan
    Department of Ophthalmology, New York University Medical Center, New York, New York, USA
    Retina 32:1057-68. 2012
    ..To describe simultaneous scanning laser ophthalmoscope indocyanine green angiographic and eye-tracked spectral-domain optical coherence tomography findings in eyes with polypoidal choroidal vasculopathy (PCV)...
  73. doi Reproducibility of fluorescein and indocyanine green angiographic assessment for RAP diagnosis: a multicenter study
    Mariacristina Parravano
    G B Bietti Eye Foundation IRCCS, Rome, Italy
    Eur J Ophthalmol 22:598-606. 2012
    ....
  74. doi Choroidal changes associated with reticular pseudodrusen
    Giuseppe Querques
    Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris Est Creteil, Creteil, France
    Invest Ophthalmol Vis Sci 53:1258-63. 2012
    ..To analyze choroidal changes associated with reticular pseudodrusen by indocyanine green angiography (ICGA) and enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT)...
  75. ncbi EVEREST study: efficacy and safety of verteporfin photodynamic therapy in combination with ranibizumab or alone versus ranibizumab monotherapy in patients with symptomatic macular polypoidal choroidal vasculopathy
    Adrian Koh
    Eye and Retina Surgeons Clinic, Camden Medical Centre, Singapore, Singapore
    Retina 32:1453-64. 2012
    ..To assess the effects of verteporfin photodynamic therapy (PDT) combined with ranibizumab or alone versus ranibizumab monotherapy in patients with symptomatic macular polypoidal choroidal vasculopathy...
  76. pmc Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform
    Wei Song
    Northwestern University, Department of Biomedical Engineering, Evanston, Illinois 60208, USA
    J Biomed Opt 17:061206. 2012
    ..PAOM with scanning laser ophthalmoscopy (SLO), spectral-domain optical coherence tomography (SD-OCT), and fluorescein angiography (FA)...
  77. doi Ocular phenotype analysis of a family with biallelic mutations in the BEST1 gene
    Dror Sharon
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Ophthalmol 157:697-709.e1-2. 2014
    ..To investigate the genetic cause and perform a comprehensive clinical analysis of a Danish family with autosomal recessive bestrophinopathy; to investigate whether Bestrophin may be expressed in normal human retina...
  78. ncbi Retinal choroidal anastomoses and occult choroidal neovascularization in age-related macular degeneration
    J S Slakter
    Vitreous Retina Macula Consultants of New York, New York 10021, USA
    Ophthalmology 107:742-53; discussion 753-4. 2000
    ....
  79. ncbi Retinal thickness in diabetic retinopathy: a study using optical coherence tomography (OCT)
    Winfried Goebel
    Departmnent of Ophthalmology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Retina 22:759-67. 2002
    ..The relationship between retinal thickness and standard methods of evaluating macular edema was investigated...
  80. ncbi Myopic choroidal neovascularization: a 10-year follow-up
    Takeshi Yoshida
    Department of Ophthalmology and Visual Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Ophthalmology 110:1297-305. 2003
    ..To clarify the long-term visual outcome of choroidal neovascularization (CNV) in eyes with high myopia in Asian patients...
  81. ncbi Intravitreal bevacizumab for choroidal neovascularization caused by AMD (IBeNA Study): results of a phase 1 dose-escalation study
    Rogerio A Costa
    U D A T Macular Imaging and Treatment Division, Hospital de Olhos de Araraquara, Araraquara, SP, Brazil
    Invest Ophthalmol Vis Sci 47:4569-78. 2006
    ..To evaluate the safety of three dose regimens of intravitreal bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA) for the management of choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD)...
  82. ncbi Efficacy of intravitreal bevacizumab for polypoidal choroidal vasculopathy
    F Gomi
    Department of Ophthalmology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Br J Ophthalmol 92:70-3. 2008
    ..The aim of the study was to assess the short-term efficacy of intravitreal injections of bevacizumab for polypoidal choroidal vasculopathy (PCV)...
  83. doi Polypoidal choroidal vasculopathy and treatments
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Curr Opin Ophthalmol 19:208-12. 2008
    ..This review assesses the current knowledge of the clinical characteristics of polypoidal choroidal vasculopathy and treatments...
  84. doi Marked vascular changes of polypoidal choroidal vasculopathy after photodynamic therapy
    T Wakabayashi
    Department of Ophthalmology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Br J Ophthalmol 92:936-40. 2008
    ..To clarify vascular changes of polypoidal choroidal vasculopathy (PCV) after photodynamic therapy (PDT)...
  85. doi Effect of triamcinolone acetonide on vascular endothelial growth factor and occludin levels in branch retinal vein occlusion
    Ian L McAllister
    Lions Eye Institute, Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia
    Am J Ophthalmol 147:838-46, 846.e1-2. 2009
    ..To investigate the molecular mechanism by which triamcinolone acetonide (TA) may reduce edema in a porcine model of branch retinal vein occlusion (BRVO)...
  86. pmc Pneumatic displacement and intravitreal bevacizumab: a new approach for management of submacular hemorrhage in choroidal neovascular membrane
    Shobhit Chawla
    Vitreo Retinal Services, Lucknow, India
    Indian J Ophthalmol 57:155-7. 2009
    ..05 ml, along with 0.5 ml of SF6 was injected through the pars plana into the vitreous cavity. Postoperative best corrected visual acuity improved in all eyes with complete or partial displacement of SMH out of the foveal area...
  87. doi Automated segmentation of foveal avascular zone in fundus fluorescein angiography
    Yalin Zheng
    Ophthalmology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Invest Ophthalmol Vis Sci 51:3653-9. 2010
    ..METHODS. A computerized technique for automated segmentation of the FAZ using images from fundus fluorescein angiography (FFA) was applied to 26 transit-phase images obtained from patients with various grades of diabetic ..
  88. pmc Detection of cystoid macular edema with three-dimensional optical coherence tomography versus fluorescein angiography
    Yanling Ouyang
    Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 51:5213-8. 2010
    To compare the sensitivity and reproducibility of three-dimensional optical coherence tomography (3D-OCT) and fluorescein angiography (FA) for the detection of cystoid macular edema (CME).
  89. pmc The anti-angiogenic effect of chlorogenic acid on choroidal neovascularization
    Cinoo Kim
    Department of Ophthalmology, Incheon Medical Center, Incheon, Korea
    Korean J Ophthalmol 24:163-8. 2010
    ..To evaluate the inhibitory effect of chlorogenic acid on laser-induced choroidal neovascularization (CNV) in a rat model...
  90. pmc Cone structure in retinal degeneration associated with mutations in the peripherin/RDS gene
    Jacque L Duncan
    Department of Ophthalmology, UCSF School of Medicine, 10 Koret Way, Room K 129, San Francisco, CA 94143 0730, USA
    Invest Ophthalmol Vis Sci 52:1557-66. 2011
    ..To study cone photoreceptor structure and function associated with mutations in the second intradiscal loop region of peripherin/RDS...
  91. doi Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy
    Michael F Marmor
    Eye Institute at Stanford, Stanford University, Palo Alto, California, USA
    Ophthalmology 118:415-22. 2011
    ..No treatment exists as yet for this disorder, so it is imperative that patients and their physicians be aware of the best practices for minimizing toxic damage...
  92. doi Reversible retinal changes in the acute stage of sympathetic ophthalmia seen on spectral domain optical coherence tomography
    Vishali Gupta
    Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India
    Int Ophthalmol 31:105-10. 2011
    ..These changes are reversible following systemic corticosteroid therapy thus supporting the hypothesis that prompt and aggressive anti-inflammatory therapy is capable of reversing the photoreceptor changes...
  93. doi Indocyanine green angiography: a perspective on use in the clinical setting
    Lawrence A Yannuzzi
    LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, and the Macula Foundation, Inc, New York, NY 10065, USA
    Am J Ophthalmol 151:745-751.e1. 2011
    ..To review the history of indocyanine green (ICG) angiography and to present a personal perspective on its use in the clinical setting today...
  94. pmc The association of age-related maculopathy susceptibility 2 polymorphisms with phenotype in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
    Hiroaki Bessho
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Mol Vis 17:977-82. 2011
    ....
  95. pmc The association between drusen extent and foveolar choroidal blood flow in age-related macular degeneration
    Thomas L Berenberg
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Retina 32:25-31. 2012
    ..To investigate the relationship between drusen extent and foveolar choroidal blood flow in nonexudative age-related macular degeneration...
  96. ncbi Intraocular injection of crystalline cortisone as adjunctive treatment of diabetic macular edema
    J B Jonas
    Department of Ophthalmology and Eye Hospital, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
    Am J Ophthalmol 132:425-7. 2001
    ..To report the clinical outcome of a diabetic patient with macular edema treated with an intravitreal injection of crystalline cortisone...
  97. ncbi Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin: fluorescein angiographic guidelines for evaluation and treatment--TAP and VIP report No. 2
    Irene Barbazetto
    Medizinische Universitat zu Lubeck, Klinik fur Augenheilkunde, Lubeck, Germany
    Arch Ophthalmol 121:1253-68. 2003
    ....
  98. ncbi Serous macular detachment in diabetic cystoid macular oedema
    Hakan Ozdemir
    Istanbul Retina Institute Inc, Hakki Yeten Cad No 8 7, Fulya, Istanbul, Turkey
    Acta Ophthalmol Scand 83:63-6. 2005
    ..To define serous macular detachment in patients with diabetic cystoid macular oedema (CME)...
  99. ncbi Treatment of retinal angiomatous proliferation in age-related macular degeneration: a series of 104 cases of retinal angiomatous proliferation
    Ferdinando Bottoni
    Department of Ophthalmology, San Giuseppe Hospital, Milan, Italy
    Arch Ophthalmol 123:1644-50. 2005
    ..To report the management of retinal angiomatous proliferation (RAP), a recently described intraretinal neovascular lesion occurring in age-related macular degeneration...
  100. ncbi Ultrahigh resolution optical coherence tomography in macular dystrophy
    Matthias G Wirtitsch
    Department of Ophthalmology, Medical University of Vienna, Wahringer Strasse 13, 1090 Vienna, Austria
    Am J Ophthalmol 140:976-983. 2005
    ..To visualize and investigate intraretinal changes in macular dystrophies with ultrahigh resolution optical coherence tomography (UHR OCT)...
  101. ncbi Effect of viagra on retinal vein diameter in AMD patients
    Tatyana I Metelitsina
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA
    Exp Eye Res 83:128-32. 2006
    ..Whether this vasodilatation is associated with changes in retinal blood flow needs to be further investigated...

Research Grants74

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..will have frequent blood and urine tests, and will also have eye examinations and special procedures (fluorescein angiography and indocyanine green angiography) to evaluate the effectiveness of the treatment...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..will have frequent blood and urine tests, and will also have eye examinations and special procedures (fluorescein angiography and indocyanine green angiography) to evaluate the effectiveness of the treatment...
  3. CCR3: a molecular marker for neovascular AMD
    Jayakrishna Ambati; Fiscal Year: 2010
    ..CCR3 detected CNV within the mouse choroid that had not yet invaded the retina and was invisible to fluorescein angiography. These findings define CCR3 as a novel specific molecular early diagnostic and therapeutic target in ..
  4. Portable Retinal Imaging Device for Urgent Referrals and Remote Treatment
    Matthew S Muller; Fiscal Year: 2012
    ..These high contrast images, along with fluorescein angiography (after a patient's ingestion of fluorescein dye) will detect treatable areas of vascular leakage and ..
  5. Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
    Scott E Fraser; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Since its first use in the retina in 1961, fluorescein angiography (FA) has been the gold standard for objective characterization of retinovascular disease (e.g...
  6. Dynamic ICG and FA Software
    Timothy Holmes; Fiscal Year: 2009
    ..of the dye filling and draining through the vessels, modalities called dynamic ICG (d-ICG) or dynamic Fluorescein Angiography (d-FA)...
  7. Regulation of vascular leakage in age related macular degeneration
    MEREDITH GREGORY-KSANDER; Fiscal Year: 2013
    ..However, fluorescein angiography revealed a significant decrease in vascular leakage in [unreadable]CS mice as compared to wild-type mice...
  8. Maureen G Maguire; Fiscal Year: 2016
    ..for measurement of visual acuity, optical coherent tomography (OCT), and fundus photography including fluorescein angiography. Previous large-scale clinical trials sponsored by industry have not provided reliable data on the long ..
  9. Qifa Zhou; Fiscal Year: 2015
    ..Techniques currently used for diagnostic imaging of AMD include indocyanine green dye or fluorescein angiography, autofluorescence imaging and optical coherence tomography (OCT)...
  10. Ingrid U Scott; Fiscal Year: 2016
    ..visual acuity letter score, SD-OCT, stereoscopic fundus photography and, at selected sites, widefield fluorescein angiography. Potential adverse events will be monitored with respect to frequency and severity...
  11. Gui Shuang Ying; Fiscal Year: 2014
    ..2) To describe the morphologic changes captured by OCT and fluorescein angiography over time during 2 years of treatment, and to evaluate whether the morphologic responses at 3 months ..
  12. Scott E Fraser; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Since its introduction in the 1960's, fluorescein angiography (FA) has been the gold standard for retinal vascular diagnosis...
  13. Sina Farsiu; Fiscal Year: 2016
    ..We propose two interrelated hypotheses based on this paradigm: 1) Fluorescein angiography (FA) and SD-OCT can be quantitatively analyzed using automated algorithms to infer the specific disease ..
  14. ENDOTHELIAL CELL AUTOIMMUNITY IN DIABETIC RETINOPATHY
    Ramesh Nayak; Fiscal Year: 2001
    ..Autoantibody will be injected into the vitreous space in the eyes of normal rats that will be examined by fluorescein angiography for anomalies in retinal circulation times...
  15. VISUAL FUNCTION IN RETINAL ISCHEMIA
    Mary Johnson; Fiscal Year: 1992
    ..development of neovascularization (NV), thus making the ERG a tool that is potentially more useful than fluorescein angiography in identifying patients that are at risk...
  16. Therapeutic Potential of A Novel Angiogenic Inhibitor
    James Ryan; Fiscal Year: 2003
    ..Its effect on retinal neovascularization will be evaluated by fluorescein angiography and quantification of pre-retinal vascular cells...
  17. Retinal blood barrier permeability using optical tracers
    FREDERICK HASELTON; Fiscal Year: 2004
    ..abstract_text> ..
  18. Novel Assessment of Early Changes in Diabetic Retinopathy
    Quan Dong Nguyen; Fiscal Year: 2010
    ..macular edema has relied on the presence of clinical signs visible through fundus photography or invasive fluorescein angiography. However, advances are being made in the early treatment that should prevent such proliferative changes ..
  19. Ocular Inflammation-Chemical and Physiological Aspects
    CHRISTOPHER PATERSON; Fiscal Year: 2003
    ..Inflammation will be evaluated by several methods including iris fluorescein angiography and determination of protein and leukocytes in aqueous humor...
  20. Evaluation of Kininostatin for Treatment of Wet AMD
    Sheila Connelly; Fiscal Year: 2005
    ..Inhibition of neovascularization/vascular leakage will be evaluated through several methods including fluorescein angiography and histological analyses...
  21. LASER HEMOSTASIS WITH SILICON NAPHTHALOCYANINES
    ROBERT SCHLIER; Fiscal Year: 1991
    ..of vascular closure and the presence of retinal damage, if any, will be evaluated by fundus photography, fluorescein angiography, and history. Experimental choroidal neovascularization in monkeys will be treated in Phase II.
  22. SUBRETINAL TRANSPLANTATION OF ISLETS OF LANGERHANS
    Dennis Rickman; Fiscal Year: 2000
    ..Any related alterations in retinal function and structure will be determined using fundus photography, fluorescein angiography, electroretinography and histological and electron microscopic techniques.
  23. Retcam 120 Wide Field Digital Imaging System
    Anne Fulton; Fiscal Year: 2002
    ..The highly magnified RetCam images of the macula, including those obtained with fluorescein angiography, will, provide new information about this late-maturing portion of the central retina that may be ..
  24. ORBITAL RADIOTHERAPY FOR GRAVES OPHTHALMOPATHY
    Colum Gorman; Fiscal Year: 2000
    ..Each evaluation will include, an orbital CT scan. Fluorescein angiography will be performed on admission and three years later...
  25. RADIATION AND AMD PLANNING GRANT
    Stuart Fine; Fiscal Year: 1999
    ..Evaluate radiation treatment for CNV lesions which have been treated with laser but show leakage on fluorescein angiography (Recurrent CNVSubstudy); 3...
  26. ESTROGEN EFFECT ON COLLATERAL GROWTH AND FUNCTION
    Kathryn Lamping; Fiscal Year: 2001
    ....
  27. Super Resolution FA Retinal Imager
    GAVIN ERRY; Fiscal Year: 2005
    ..The first Aim is to modify an existing adaptive optics fundus imager to create the first Super Resolution Fluorescein Angiography Retinal Imager (SFARI) device...
  28. Spectral Triangulation Molecular Contrast OCT
    Changhuei Yang; Fiscal Year: 2005
    ..abstract_text> ..
  29. Novel Therapy for Wet Age-Related Macular Degeneration
    Sheila Connelly; Fiscal Year: 2006
    ..Inhibition of neovascularization/vascular leakage will be evaluated through several methods including fluorescein angiography and histological analyses...
  30. DIABETIC RETINOPATHY IN NONHUMAN PRIMATES
    CHARLES VYGANTAS; Fiscal Year: 1980
    ..Findings of fundus photography, fluorescein angiography and vitreous fluorophotometry will be correlated with histologic and ultrastructural changes in the ..
  31. A LONGITUDINAL STUDY OF HYPERTENSIVE RETINOPATHY
    Lee Jampol; Fiscal Year: 1980
    ..A complete ophthalmologic examination including fundus photography and fluorescein angiography is performed. The retinopathy is classified following a new scheme developed by the investigators...
  32. DISCIFORM MACULAR DISEASE: CONTROLLED TREATMENT TRIAL
    Alan Bird; Fiscal Year: 1980
    ..will be assessed for suitability for entry by clinical examination, visual acuity and field assessment, fluorescein angiography and color photography...
  33. BLOOD GLUCOSE-HEMOGLOBIN A1C & DIABETIC VASCULAR DISEASE
    KENNETH GABBAY; Fiscal Year: 1990
    ..disease in the retina of these young- adult diabetics by serial ophthalmological examinations (clinical, fluorescein angiography, fundus photography, retinal blood flow measurement by the laser Doppler technique), 2) further refine ..
  34. Genetics of Age-Related Macular Degeneration
    John Heckenlively; Fiscal Year: 2007
    ..in mouse including a standardized cone and rod ERG, which is now widely used, multifocal ERG testing, sweep VECP for measuring visual acuity in mouse, and fundus photography and fluorescein angiography of mouse retina.
  35. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  36. OCULAR HEMODYNAMICS IN GLAUCOMA
    Juan Grunwald; Fiscal Year: 2001
    ..If hemodynamic abnormalities are present, then attention can be focused on altering the optic nerve circulation as a means of treating glaucoma. ..
  37. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  38. Retinopathy in Chronic Renal Insufficiency
    Juan E Grunwald; Fiscal Year: 2010
    ....
  39. Choroidal circulation in age related macular degeneration
    Juan Grunwald; Fiscal Year: 2008
    ..In addition, the knowledge gained through this investigation could also help in the identification of patients at risk of developing choroidal neovascularization, thus enabling earlier treatment. [unreadable] [unreadable] [unreadable]..
  40. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
    ..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
  41. QUALITY OF LIFE AND COST EFFECTIVENESS IN CMV RETINITIS
    John Kempen; Fiscal Year: 2002
    ..Subanalyses will assess what factors other than treatment strategy are associated with improved QOL and cost-effectiveness. ..
  42. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
    ..b>Fluorescein angiography has shown that CNV may have classic and occult patterns, each of which correlates with a different ..
  43. CYTOKINE MODULATION IN PROLIFERATIVE VITREORETINOPATHY
    GLENN JAFFE; Fiscal Year: 2005
    ..Density-dependent effects of IL-1, TNFalpha, and specific NF-kappaB inhibitors on NF-kappaB-mediated RPE apoptosis will be quantified. IV) To determine whether specific in vivo NF-kappaB blockade inhibits PVR. ..
  44. A CRYSTALLIN MUTATION WITH ABNORMAL ASTROCYTES AND RETINAL VESSELS
    Debasish Sinha; Fiscal Year: 2010
    ..We believe that studies on the Nuc1 rat will provide new insights into the cellular and molecular mechanisms that regulate vascular development including the molecular interactions among neurons, astrocytes and endothelial cells. ..
  45. MOLECULAR IMAGING OF ADVANCED BLADDER CANCER
    JOHN FRANGIONI; Fiscal Year: 2002
    ..We believe that bladder cancer-specific, low-molecular weight ligands will someday be clinically useful reagents for improved detection and guided therapy of transitional cell carcinoma of the bladder. ..
  46. OCULAR MELANOMA
    Barbara Hawkins; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  47. Eye Disease in Cuban-American and Puerto Rican Adults
    Ingrid Scott; Fiscal Year: 2003
    ..g. NEI-VFQ 25) and eye service use. Subjects who refuse will be questioned as to reason(s) for refusal. ..
  48. PIGMENT EPITHELIUM REMOVAL AND TRANSPLANTATION
    Marco Zarbin; Fiscal Year: 2003
    ..IV: Assess long-term viability of syngeneic RPE sheet transplants onto damaged Bruch's membrane using a published in vivo RPE debridement model. ..
  49. Central Scotomas in AMD and Cortical Remapping
    Janet Sunness; Fiscal Year: 2005
    ....
  50. INHIBITION OF ANGIOGENESIS BY TRUNCATED FGF RECEPTORS
    Anne Hanneken; Fiscal Year: 2001
    ..Specific Aim 5 is designed to determine how conditions which alter the levels of truncated FGFRs in the extracellular matrix modulate the biological activity of the extracellular matrix stores of FGF- 2. ..
  51. Objective Flap Assessment During Reconstructive Surgery
    JOHN FRANGIONI; Fiscal Year: 2009
    ..With the completion of these studies, we foresee being able to solve major clinical problems in reconstructive surgery using real-time, intraoperative objective assessment. ..
  52. High Throughput Assays for Ion Channel Activities of Influenza A & B Viruses
    LAWRENCE PINTO; Fiscal Year: 2006
    ..These assays will make it possible to perform efficient searches for antiviral drugs against the M2 ion channels. [unreadable] [unreadable] [unreadable] [unreadable]..
  53. Multifunctional Antioxidants as Anti-Cataract Agents
    Peter Kador; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  54. COORDINATING CENTER: VISION IN PRESCHOOLERS
    Maureen Maguire; Fiscal Year: 2005
    ..abstract_text> ..
  55. Single Shot OCT
    Daniel Hammer; Fiscal Year: 2006
    ..In addition, the developed instrument and the principles upon which it is based may be used to image other disease types throughout the human body. [unreadable] [unreadable] [unreadable]..
  56. NEUTROPHINS AND RETINAL DEVELOPMENT
    Janet Sparrow; Fiscal Year: 2001
    ..The use of neurotrophins in conjunction with gene therapy or transplantation may also have potential for reversing retinal degenerative changes and lead to the restoration of vision. ..
  57. Fourth NEI Symposium on the Epidemiology of Eye Diseases and Vision Disorders
    Barbara Hawkins; Fiscal Year: 2007
    ..Guest editors from the Planning Committee will be responsible for peer review and other scientific editorial tasks for manuscripts submitted for publication in the special issue of the journal. ..
  58. RESPIRATORY VIRUS ION CHANNELS
    LAWRENCE PINTO; Fiscal Year: 2007
    ..5. In a separate set of experiments we will use a sensitive method to test the NB protein of influenza B virus for ion channel activity. [unreadable] [unreadable] [unreadable]..
  59. COORDINATING CENTER FOR AMD PREVENTION TRIAL
    Maureen Maguire; Fiscal Year: 2006
    ..Design and implement a full program of quality assurance activities; . Design and implement studies of quality of life assessment; . Assist with the preparation of scientific reports. ..
  60. Real-Time Three-Dimensional Motion Control Tracker
    Daniel Hammer; Fiscal Year: 2003
    ..After optimization, the Phase II instrument will be tested in a clinical ophthalmic program and the improvement in measurement of retinal features (e.g., nerve fiber layer thickness) will be quantified. ..
  61. The Role of Outer Retinal Injury in Glaucoma
    T Nork; Fiscal Year: 2004
    ..abstract_text> ..
  62. VISUAL ADAPTATION LIMITS AND AGE-RELATED DISEASE
    Alvin Eisner; Fiscal Year: 2002
    ....
  63. Genetics of Age-Related Cataracts
    Bo Chang; Fiscal Year: 2007
    ..abstract_text> ..
  64. Low-cost, portable, computer assisted imaging for diabe*
    Michael Abramoff; Fiscal Year: 2008
    ..Our overall aim is to validate and optimize a low-cost, high quality, patient friendly imaging system for the early diagnosis of diabetic retinopathy. ..
  65. Genetics of Age-Related Macular Degeneration
    Michael Klein; Fiscal Year: 2007
    ..abstract_text> ..
  66. CLINICAL CHARACTERIZATION&GENETICS OF OPTIC NERVE DRUSEN
    Bradley Katz; Fiscal Year: 2005
    ..These data may suggest novel therapies to prevent the visual field loss associated with OND. In addition, these data may yield information about other diseases of the optic nerve. ..
  67. Investigating the Molecular Mechanism of Hexose-induced Stress in Lens and Retina
    Peter F Kador; Fiscal Year: 2010
    ..Moreover, these studies should help identify new drug targets for the treatment of these diabetic complications. ..
  68. Near-Infrared Quantum Dots for In Vivo Imaging
    JOHN FRANGIONI; Fiscal Year: 2006
    ..If completed, the specific aims of this proposal will generate a clinically useful set of contrast agents, and a more complete understanding of the in vivo behavior of fluorescent semiconductor nanocrystals. [unreadable] [unreadable]..
  69. XANTHOPHYLL-MEDIATED RETINAL DRUG DELIVERY
    Dennis Marcus; Fiscal Year: 2005
    ..abstract_text> ..
  70. Female Hormones and Vision
    Alvin Eisner; Fiscal Year: 2006
    ..abstract_text> ..
  71. The Subproteome in Age-related Macular Degeneration
    Timothy Olsen; Fiscal Year: 2008
    ..This information will enable us to generate a rational approach to identify targeted therapies. ..
  72. Studies on Influenza B Virus BM2 Protein Ion Channel
    LAWRENCE PINTO; Fiscal Year: 2009
    ....