observer variation

Summary

Summary: The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).

Top Publications

  1. ncbi The kappa statistic in reliability studies: use, interpretation, and sample size requirements
    Julius Sim
    Primary Care Sciences Research Centre, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
    Phys Ther 85:257-68. 2005
  2. ncbi Understanding interobserver agreement: the kappa statistic
    Anthony J Viera
    Robert Wood Johnson Clinical Scholars Program, University of North Carolina, USA
    Fam Med 37:360-3. 2005
  3. ncbi When to use agreement versus reliability measures
    Henrica C W de Vet
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
    J Clin Epidemiol 59:1033-9. 2006
  4. pmc Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    JACC Cardiovasc Imaging 5:596-603. 2012
  5. pmc Simultaneous truth and performance level estimation (STAPLE): an algorithm for the validation of image segmentation
    Simon K Warfield
    Harvard Medical School and the Department of Radiology of Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    IEEE Trans Med Imaging 23:903-21. 2004
  6. ncbi Anthropometric measurement error and the assessment of nutritional status
    S J Ulijaszek
    Institute of Biological Anthropology, University of Oxford, UK
    Br J Nutr 82:165-77. 1999
  7. ncbi Prediction of all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring
    Tony Stanton
    School of Medicine, University of Queensland, Brisbane, Australia
    Circ Cardiovasc Imaging 2:356-64. 2009
  8. ncbi Observer variation in immunohistochemical analysis of protein expression, time for a change?
    T Kirkegaard
    Endocrine Cancer Group, Division of Cancer Studies and Molecular Pathology, University Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK
    Histopathology 48:787-94. 2006
  9. pmc Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situ hybridization (FISH): pathologist assessment compared to quantitative image analysis
    Gulisa Turashvili
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Cancer 9:165. 2009
  10. ncbi Measurement of observer agreement
    Harold L Kundel
    Department of Radiology and MCP Hahnemann School of Public Health, University of Pennsylvania Medical Center, 3600 Market St, Suite 370, Philadelphia, PA 19104, USA
    Radiology 228:303-8. 2003

Detail Information

Publications402 found, 100 shown here

  1. ncbi The kappa statistic in reliability studies: use, interpretation, and sample size requirements
    Julius Sim
    Primary Care Sciences Research Centre, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
    Phys Ther 85:257-68. 2005
    ..This article examines and illustrates the use and interpretation of the kappa statistic in musculoskeletal research...
  2. ncbi Understanding interobserver agreement: the kappa statistic
    Anthony J Viera
    Robert Wood Johnson Clinical Scholars Program, University of North Carolina, USA
    Fam Med 37:360-3. 2005
    ..A limitation of kappa is that it is affected by the prevalence of the finding under observation. Methods to overcome this limitation have been described...
  3. ncbi When to use agreement versus reliability measures
    Henrica C W de Vet
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
    J Clin Epidemiol 59:1033-9. 2006
    ..Consequently, reliability parameters are highly dependent on the heterogeneity of the study sample, while the agreement parameters, based on measurement error, are more a pure characteristic of the measurement instrument...
  4. pmc Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction
    Martin Ugander
    Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    JACC Cardiovasc Imaging 5:596-603. 2012
    ..The aim of this study was to determine whether cardiac magnetic resonance (CMR) in vivo T1 mapping can measure myocardial area at risk (AAR) compared with microspheres or T2 mapping CMR...
  5. pmc Simultaneous truth and performance level estimation (STAPLE): an algorithm for the validation of image segmentation
    Simon K Warfield
    Harvard Medical School and the Department of Radiology of Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    IEEE Trans Med Imaging 23:903-21. 2004
    ..STAPLE is straightforward to apply to clinical imaging data, it readily enables assessment of the performance of an automated image segmentation algorithm, and enables direct comparison of human rater and algorithm performance...
  6. ncbi Anthropometric measurement error and the assessment of nutritional status
    S J Ulijaszek
    Institute of Biological Anthropology, University of Oxford, UK
    Br J Nutr 82:165-77. 1999
    ..Anthropometry is an important tool for nutritional assessment, and the techniques reported here should allow increased precision of measurement, and improved interpretation of anthropometric data...
  7. ncbi Prediction of all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring
    Tony Stanton
    School of Medicine, University of Queensland, Brisbane, Australia
    Circ Cardiovasc Imaging 2:356-64. 2009
    ..The aim of this study was to compare global longitudinal speckle strain (GLS), an automated technique for measurement of long-axis function, with EF and WMSI for the prediction of mortality...
  8. ncbi Observer variation in immunohistochemical analysis of protein expression, time for a change?
    T Kirkegaard
    Endocrine Cancer Group, Division of Cancer Studies and Molecular Pathology, University Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK
    Histopathology 48:787-94. 2006
    ..Interobserver variation is rarely analysed despite recognition that this is a key area of potential inaccuracy. Therefore our aim was to examine observer variation and suggest the revision of current standards.
  9. pmc Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situ hybridization (FISH): pathologist assessment compared to quantitative image analysis
    Gulisa Turashvili
    Molecular Oncology and Breast Cancer Program, British Columbia Cancer Research Centre, Vancouver, BC, Canada
    BMC Cancer 9:165. 2009
    ..Our study compares HER2 scoring by histopathologists with automated quantitation of staining, and determines the concordance of IHC scores with FISH results...
  10. ncbi Measurement of observer agreement
    Harold L Kundel
    Department of Radiology and MCP Hahnemann School of Public Health, University of Pennsylvania Medical Center, 3600 Market St, Suite 370, Philadelphia, PA 19104, USA
    Radiology 228:303-8. 2003
    ..Other measures of agreement that are used less frequently, including multiple-rater kappa, are referenced and described briefly...
  11. pmc Small (≤ 2 cm) hepatocellular carcinoma in patients with chronic liver disease: comparison of gadoxetic acid-enhanced 3.0 T MRI and multiphasic 64-multirow detector CT
    J Hwang
    Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Br J Radiol 85:e314-22. 2012
    ..0 T with that of multiphasic 64-multirow detector CT (MDCT) for the detection of small (≤2 cm) hepatocellular carcinoma (HCC) in patients with chronic liver disease...
  12. ncbi Observer variation in the sonographic measurement of optic nerve sheath diameter in normal adults
    S A Ballantyne
    Department of Radiology and Clinical Physics, Royal Hospital for Sick Children, G46 7PD, Glasgow, UK
    Eur J Ultrasound 15:145-9. 2002
    To quantify the observer variation in the sonographic measurement of optic nerve sheath diameter (ONSD) in normal adults.
  13. pmc Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender
    Daniel Augustine
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 15:8. 2013
    ..We used it to record deformation parameters in healthy adults and compared values to those obtained by tagging...
  14. ncbi Variability in small bowel histopathology reporting between different pathology practice settings: impact on the diagnosis of coeliac disease
    Carolina Arguelles-Grande
    Celiac Disease Center at Columbia University Medical Center, Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, New York, USA
    J Clin Pathol 65:242-7. 2012
    ..This study evaluated the agreement in biopsy interpretation between different pathology practice types...
  15. ncbi Interobserver and intraobserver variability in interpretation of lumbar disc abnormalities. A comparison of two nomenclatures
    M N Brant Zawadzki
    Hoag Memorial Hospital, Newport Beach, California, USA
    Spine (Phila Pa 1976) 20:1257-63; discussion 1264. 1995
    ..CONCLUSIONS. Experienced readers using standardized nomenclature showed moderate to substantial agreement with interpreting disc extension beyond the interspace on magnetic resonance imaging...
  16. pmc A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation
    R Graham Barr
    Division of Radiology, National Jewish Health, Denver, CO 80206, USA
    COPD 9:151-9. 2012
    ....
  17. ncbi The impact of gross tumor volume (GTV) and clinical target volume (CTV) definition on the total accuracy in radiotherapy theoretical aspects and practical experiences
    Elisabeth Weiss
    Department of Radiation Therapy, University of Gottingen, Germany
    Strahlenther Onkol 179:21-30. 2003
    ..To evaluate the impact of interobserver variability in the contouring of gross tumor volumes (GTVs) and clinical target volumes (CTVs) on the global geometric accuracy in radiation therapy...
  18. ncbi Reliability of photogrammetry in the evaluation of the postural aspects of individuals with structural scoliosis
    Karen Ruggeri Saad
    School of Medicine, Vale do São Francisco Federal University, Av José de Sá Maniçoba, Petrolina PE 56304 917, Brazil
    J Bodyw Mov Ther 16:210-6. 2012
    ..The purpose of this study was to investigate the reliability of photogrammetry in the measurement of the postural deviations in individuals with idiopathic scoliosis...
  19. pmc Inter-examiner reproducibility of tests for lumbar motor control
    Flemming Enoch
    Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    BMC Musculoskelet Disord 12:114. 2011
    ..This has not been considered before. The aim was to analyse the reproducibility of five different quantitative tests for LMC commonly used in daily clinical practice...
  20. pmc Comparison between cardiovascular magnetic resonance and transthoracic Doppler echocardiography for the estimation of effective orifice area in aortic stenosis
    Julio Garcia
    Quebec Heart and Lung Institute, Laval University, Quebec, Canada
    J Cardiovasc Magn Reson 13:25. 2011
    ..Cardiovascular magnetic resonance (CMR) has emerged as an alternative method for non-invasive estimation of valve EOA. The objective of this study was to assess the concordance between TTE and CMR for the estimation of valve EOA...
  21. ncbi Reproducibility of quantitative optical coherence tomography for stent analysis
    Nieves Gonzalo
    Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    EuroIntervention 5:224-32. 2009
    ..To assess the inter- and intra- observer reproducibility for strut count, strut apposition and strut tissue coverage measurements with optical coherence tomography (OCT)...
  22. ncbi The limits of agreement and the intraclass correlation coefficient may be inconsistent in the interpretation of agreement
    Cristina Costa-Santos
    Biostatistics and Medical Informatics Department, Faculty of Medicine, University of Porto, Porto, Portugal
    J Clin Epidemiol 64:264-9. 2011
    ..To compare the interpretation of agreement in the prediction of neonatal outcome variables, using the limits of agreement (LA) and the intraclass correlation coefficient (ICC)...
  23. pmc Lymphovascular invasion in colorectal cancer: an interobserver variability study
    Elizabeth I Harris
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Surg Pathol 32:1816-21. 2008
    ..This study was undertaken to examine such interobserver variability, and we hypothesized that the use of immunohistochemical markers for vascular and lymphatic channels could improve interobserver agreement...
  24. pmc Inter-rater reliability of manual muscle strength testing in ICU survivors and simulated patients
    Eddy Fan
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA
    Intensive Care Med 36:1038-43. 2010
    ..The goal of the paper is to determine inter-rater reliability of trained examiners performing standardized strength assessments using manual muscle testing (MMT)...
  25. ncbi Magnetic resonance imaging and magnetic resonance arthrography of the shoulder: dependence on the level of training of the performing radiologist for diagnostic accuracy
    John S Theodoropoulos
    Division of Orthopaedics, Mount Sinai Hospital and the University Health Network, University of Toronto, Room 476c, 600 University Avenue, Toronto, ON, M5G 1X5, Canada
    Skeletal Radiol 39:661-7. 2010
    ..The purpose of this study was to evaluate the diagnostic performance of MR imaging examinations of the shoulder with regard to the training level of the performing radiologist...
  26. ncbi Phantom study on radiotherapy planning using PET/CT--delineation of GTV by evaluating SUV
    Fumiaki Uto
    Department of Radiology, Takai Hospital, Nara 632 0006, Japan
    J Radiat Res 51:157-64. 2010
    ..An SUV of 40-50% of the maximum is suggested to be appropriate for GTV contouring of sphere tumors with homogenously distributed (18)F-FDG...
  27. ncbi Evaluation of a new carotid intima-media thickness measurement by B-mode ultrasonography using an innovative measurement software, intimascope
    Toshihiko Yanase
    Department of Medicine and Bioregulatory Science, Third Department of Internal Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Am J Hypertens 19:1206-12. 2006
    ..Carotid aver-IMT measurement using the new Intimascope software may provide a more precise and reproducible index of atherosclerosis than does conventional IMT measurement...
  28. ncbi Duodenal intraepithelial lymphocyte-count revisited
    B Veress
    Dept of Pathology, University Hospital MAS, Malmo, Sweden
    Scand J Gastroenterol 39:138-44. 2004
    ..The number of intraepithelial lymphocytes in the duodenum was determined 30 years ago, the suggested normal upper limit being 40 lymphocytes per 100 epithelial cells...
  29. ncbi Digital breast tomosynthesis: observer performance study
    David Gur
    Radiology Imaging Research, Department of Radiology, University of Pittsburgh, 3362 Fifth Ave, Rm 223 FARP Bldg, Pittsburgh, PA 15213, USA
    AJR Am J Roentgenol 193:586-91. 2009
    ..The purpose of this study was to compare in a retrospective observer study the diagnostic performance of full-field digital mammography (FFDM) with that of digital breast tomosynthesis...
  30. ncbi Prostate cancer: body-array versus endorectal coil MR imaging at 3 T--comparison of image quality, localization, and staging performance
    Stijn W T P J Heijmink
    Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, NL 6500 HB, Nijmegen, The Netherlands
    Radiology 244:184-95. 2007
    ....
  31. ncbi Accuracy of PET for diagnosis of solid pulmonary lesions with 18F-FDG uptake below the standardized uptake value of 2.5
    Yaichiro Hashimoto
    Division of Nuclear Medicine, Department of Radiology, School of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    J Nucl Med 47:426-31. 2006
    ..5. However, the frequency of malignancies with an SUV of <2.5 is significant, and pulmonary nodules with low 18F-FDG uptake often present diagnostic challenges...
  32. ncbi Reliability of malaria microscopy in epidemiological studies: results of quality control
    A H Kilian
    Basic Health Services Project, Gesellschaft für Technische Zusammenarbeit mbH GTZ, Fort Portal, Uganda
    Trop Med Int Health 5:3-8. 2000
    ..Care must be taken, however, when individual parasite density is related to other explanatory variables, due to the high degree of variability in the parasite enumeration...
  33. ncbi Computer recognition of regional lung disease patterns
    R Uppaluri
    Department of Electrical and Computer Engineering and Radiology, Divison of Pulmonary, Department of Internal Medicine, The University of Iowa, Iowa City, Iowa, USA
    Am J Respir Crit Care Med 160:648-54. 1999
    ..62. For regional tissue characterization, the AMFM is 100% reproducible and performs as well as experienced human observers who have been told the patient diagnosis...
  34. ncbi Clinical validation of atlas-based auto-segmentation of multiple target volumes and normal tissue (swallowing/mastication) structures in the head and neck
    David N Teguh
    Department of Radiation Oncology, Erasmus Medical Center, Rotterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 81:950-7. 2011
    ..To validate and clinically evaluate autocontouring using atlas-based autosegmentation (ABAS) of computed tomography images...
  35. ncbi Reliability and sensitivity to change of the OMERACT rheumatoid arthritis magnetic resonance imaging score in a multireader, longitudinal setting
    Espen A Haavardsholm
    Department of Rhumatology, Diakonhjemmet Hospital, Oslo, Norway
    Arthritis Rheum 52:3860-7. 2005
    ....
  36. ncbi Lung cancer: interobserver agreement on interpretation of pulmonary findings at low-dose CT screening
    David S Gierada
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63105, USA
    Radiology 246:265-72. 2008
    ..To evaluate agreement among radiologists on the interpretation of pulmonary findings at low-dose computed tomographic (CT) screening examinations for lung cancer...
  37. ncbi Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability
    Tandy J Miller
    Yale University, New Haven, CT, USA
    Schizophr Bull 29:703-15. 2003
    ..It also presents data suggesting that excellent interrater reliability can be established for diagnosis in a day-and-a-half-long training workshop...
  38. ncbi Sexing skulls using discriminant function analysis of visually assessed traits
    Phillip L Walker
    Department of Anthropology, University of California, Santa Barbara, California 93106, USA
    Am J Phys Anthropol 136:39-50. 2008
    ..Because of such population differences, discriminant functions like those presented in this paper should be used with caution on populations other than those for which they were developed...
  39. ncbi Anaesthetists' Non-Technical Skills (ANTS): evaluation of a behavioural marker system
    G Fletcher
    Department of Psychology, University of Aberdeen, King s College, UK
    Br J Anaesth 90:580-8. 2003
    ..A prototype behavioural marker system was developed using human factors research techniques. The aim of this study was to conduct an experimental evaluation to establish its basic psychometric properties and usability...
  40. ncbi Are proxy assessments of health status after stroke with the EuroQol questionnaire feasible, accurate, and unbiased?
    P J Dorman
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK
    Stroke 28:1883-7. 1997
    ..A proxy, such as a family member or caregiver, may be able to give an estimate of the patients' health status. We therefore examined the agreement between the HRQoL as assessed by a series of patients and that assessed by their proxies...
  41. ncbi Inter-observer variation in the assessment of clinical signs in sick Tanzanian children
    E Kahigwa
    Ifakara Health Research and Development Centre, P O Box 53, Ifakara, Tanzania
    Trans R Soc Trop Med Hyg 96:162-6. 2002
    ..The difficulties surrounding the diagnosis of impaired consciousness in young children should increase vigilance in the diagnosis and management of neurological complications of illnesses in infancy...
  42. ncbi Error rates in buccal-dental microwear quantification using scanning electron microscopy
    J Galbany
    Secc Antropologia, Department Biologia Animal, Universitat de Barcelona, Barcelona, Spain
    Scanning 27:23-9. 2005
    ..The substitution of semiautomatic with fully automated procedures will completely avoid interobserver error rate differences...
  43. ncbi Reader agreement studies
    Philip E Crewson
    Health Services Research and Development Service 124, Department of Veterans Affairs, 810 Vermont Ave, NW, Washington, DC 20420, USA
    AJR Am J Roentgenol 184:1391-7. 2005
  44. ncbi Analysis and comparison of the psychometric properties of three balance measures for stroke patients
    Hui Fen Mao
    School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Stroke 33:1022-7. 2002
    ....
  45. ncbi The need for treatment and satisfaction with dental appearance among young Finnish adults with and without a history of orthodontic treatment
    H Kerosuo
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    J Orofac Orthop 61:330-40. 2000
    ..The high treatment rate in relation to unnoticed treatment need calls for reevaluation of priorities in patient selection...
  46. ncbi Agreement and repeatability of central thickness measurement in normal corneas using ultrasound pachymetry and the OCULUS Pentacam
    Clare O'Donnell
    Faculty of Life Sciences, The University of Manchester, UK
    Cornea 24:920-4. 2005
    ..To compare the accuracy and repeatability of the OCULUS Pentacam (a new Scheimpflug-based imaging system) with ultrasound pachymetry in the measurement of central corneal thickness (CCT)...
  47. ncbi Accuracy and repeatability of cone-beam computed tomography (CBCT) measurements used in the determination of facial indices in the laboratory setup
    Bernard A M M L Moerenhout
    Division of Maxillo Facial Surgery, Department of Surgery, General Hospital St Jan, Bruges, Belgium
    J Craniomaxillofac Surg 37:18-23. 2009
    ..V., Mechelen, Belgium)...
  48. ncbi Evaluation of intraexaminer and interexaminer agreement on classifying lower third molars according to the systems of Pell and Gregory and of Winter
    Nieves Almendros-Marqués
    Oral and Maxillofacial Surgery, Barcelona University Dental School, Barcelona, Spain
    J Oral Maxillofac Surg 66:893-9. 2008
    ....
  49. pmc Observer reliability of three-dimensional cephalometric landmark identification on cone-beam computerized tomography
    Ana Emilia F de Oliveira
    Department of Dentistry I, Universidade Federal do Maranhao, Maranhao, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:256-65. 2009
    ..To evaluate reliability in 3-dimensional (3D) landmark identification using cone-beam computerized tomography (CBCT)...
  50. ncbi The accuracy and reliability of measurements made on computer-based digital models
    Meredith L Quimby
    Section of Orthodontics, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, USA
    Angle Orthod 74:298-303. 2004
    ..Efficacy and effectiveness were similar to those of plaster models. Therefore, computer-based models appear to be a clinically acceptable alternative to conventional plaster models...
  51. ncbi A comparison between 2D and 3D cephalometry on CBCT scans of human skulls
    O J C van Vlijmen
    3 D Facial Imaging Research Group Nijmegen Bruges, The Netherlands
    Int J Oral Maxillofac Surg 39:156-60. 2010
    ..The authors recommend that 3D tracings for longitudinal research are not used in cases were there are only 2D records from the past...
  52. pmc The prognostic impact of TGF-β1, fascin, NF-κB and PKC-ζ expression in soft tissue sarcomas
    Andrej Valkov
    Department of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
    PLoS ONE 6:e17507. 2011
    ..We aimed to investigate the prognostic impact of TGF-β1, NF-κB p105, PKC-ζ, Par-6α, E-cadherin and vimentin in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STSs)...
  53. ncbi Orthodontic treatment need in French schoolchildren: an epidemiological study using the Index of Orthodontic Treatment Need
    Mourad Souames
    Department of Epidémiologie Prévention Economie de la santé Paris University 7, France
    Eur J Orthod 28:605-9. 2006
    ..The dental health component (DHC) of the IOTN was found to be reliable and simple to use. The malocclusion status of French schoolchildren was lower than that recorded in epidemiological studies of European children...
  54. ncbi Inter-observer variability in APACHE II scoring: effect of strict guidelines and training
    K H Polderman
    Surgical Intensive Care Unit, University Hospital Vrije Universiteit, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Intensive Care Med 27:1365-9. 2001
    ..To assess the effect of strict guidelines and a rigorous training program on variability in scoring the revised Acute Physiology and Chronic Health Evaluation (APACHE II)...
  55. pmc Radiographic evaluation of the hip has limited reliability
    John C Clohisy
    Department of Orthopaedic Surgery, Washington University School of Medicine, One Barnes Hospital Plaza, Suite 11300 West Pavilion, Campus Box 8233, St Louis, MO 63110, USA
    Clin Orthop Relat Res 467:666-75. 2009
    ..Accordingly, a more clear set of definitions and measurements must be developed to allow for more reliable diagnosis of early hip disease...
  56. ncbi Tilt and rotation correction of acetabular version on pelvic radiographs
    M Tannast
    Department of Orthopaedic Surgery, Inselspital, University of Bern, Bern, Switzerland
    Clin Orthop Relat Res 438:182-90. 2005
    ..The computer-assisted method allows standardized evaluation of anatomic morphologic differences of femoral coverage (dysplasia, retroversion), making their clinical relevance for development of early osteoarthritis more valuable...
  57. ncbi Assessment of young children using the Achenbach System of Empirically Based Assessment (ASEBA)
    Leslie A Rescorla
    Department of Psychology, Bryn Mawr College, Bryn Mawr, PA 19010 2988, USA
    Ment Retard Dev Disabil Res Rev 11:226-37. 2005
    ..Clinical and research applications of ASEBA preschool forms are summarized in the paper, and strengths and limitations are discussed...
  58. ncbi Accuracy and concordance of nurses in emergency department triage
    Katarina Göransson
    Department of Health Sciences, Orebro University, Sweden
    Scand J Caring Sci 19:432-8. 2005
    ..46 (unweighted) and kappa = 0.71 (weighted). The fact that the kappa-values are only moderate to good and the low concordance between the RNs call for further studies, especially from a patient safety perspective...
  59. ncbi Can ultrasonography improve on radiographic assessment in osteoarthritis of the hands? A comparison between radiographic and ultrasonographic detected pathology
    H I Keen
    Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK
    Ann Rheum Dis 67:1116-20. 2008
    ..This study aimed to compare the detection of osteophytosis and joint space narrowing (JSN) by US and conventional radiography (CR) in OA of the hand...
  60. ncbi An admissions OSCE: the multiple mini-interview
    Kevin W Eva
    Department of Clinical Epidemiology and Biostatistics, Programme for Educational Research and Development, McMaster University, Hamilton, Ontario, Canada
    Med Educ 38:314-26. 2004
    ....
  61. ncbi (18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT
    Gerard G Hanna
    Centre for Cancer Research and Cell Biology, Queen s University of Belfast, Belfast, Northern Ireland, United Kingdom
    Int J Radiat Oncol Biol Phys 77:24-30. 2010
    ..In previously PET-CT staged patients with NSCLC, we assessed the effect of using an additional planning PET-CT scan for gross tumor volume (GTV) definition...
  62. ncbi How to perform an accurate assessment of cardiac function in mice using high-resolution magnetic resonance imaging
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
    J Cardiovasc Magn Reson 8:693-701. 2006
    ..Here, we describe a protocol that allows for a quick and reproducible approach of obtaining the relevant cardiac views for cine-MRI, and we explain how an accurate experimental image analysis can be performed...
  63. ncbi Radiation dose reduction with chest computed tomography using adaptive statistical iterative reconstruction technique: initial experience
    Priyanka Prakash
    Division of Thoracic Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Comput Assist Tomogr 34:40-5. 2010
    ..To assess radiation dose reduction and image quality for weight-based chest computed tomographic (CT) examination results reconstructed using adaptive statistical iterative reconstruction (ASIR) technique...
  64. ncbi Evaluation of automatic atlas-based lymph node segmentation for head-and-neck cancer
    Liza J Stapleford
    Department of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA
    Int J Radiat Oncol Biol Phys 77:959-66. 2010
    ..To evaluate if automatic atlas-based lymph node segmentation (LNS) improves efficiency and decreases inter-observer variability while maintaining accuracy...
  65. ncbi Measuring the similarity of target volume delineations independent of the number of observers
    Erik Kouwenhoven
    Department of Medical Physics, Medical Center Haaglanden, 2501 CK The Hague, The Netherlands
    Phys Med Biol 54:2863-73. 2009
    ..The use of the third generalization for the CI which is based upon the volume common to all delineations shows a clear dependence upon the number of delineations and is discouraged...
  66. ncbi The Strengths and Difficulties Questionnaire in the Nordic countries
    Carsten Obel
    Perinatal Epidemiological Research Unit, Dept Gynaecology and Obstetrics, Aarhus University Hospital, Skejby, 8200, Aarhus N, Denmark
    Eur Child Adolesc Psychiatry 13:II32-9. 2004
    ..The largest studies have been performed in Norway and Denmark, and in these countries the diagnostic interview DAWBA has also been used in conjunction with the SDQ...
  67. ncbi Inter-observer and intra-observer reliability for lung cancer target volume delineation in the 4D-CT era
    Alexander V Louie
    Department of Radiation Oncology, London Regional Cancer Program, London, Ont, Canada
    Radiother Oncol 95:166-71. 2010
    ..To investigate inter-observer and intra-observer target volume delineation (TVD) error in 4D-CT imaging of thoracic tumours...
  68. pmc Chest radiograph reading and recording system: evaluation for tuberculosis screening in patients with advanced HIV
    R Dawson
    University of Cape Town Lung Institute, Division of Pulmonology and E16 Respiratory Clinic, Groote Schuur Hospital, Cape Town, South Africa
    Int J Tuberc Lung Dis 14:52-8. 2010
    ..An antiretroviral treatment (ART) service in Gugulethu township, Cape Town, South Africa...
  69. ncbi Variability among breast radiation oncologists in delineation of the postsurgical lumpectomy cavity
    Daniel M Landis
    Joint Center for Radiation Therapy Residency Training Program, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 67:1299-308. 2007
    ..We examined the interobserver variability in delineation of the lumpectomy cavity among four academic radiation oncologists who specialize in the treatment of breast cancer...
  70. ncbi Are diagnostic criteria for general joint hypermobility and benign joint hypermobility syndrome based on reproducible and valid tests? A review of the literature
    Lars Remvig
    Clinic of Orthopaedic Medicine and Rehabilitation, Rigshospitalet, Copenhagen University, Denmark
    J Rheumatol 34:798-803. 2007
    ..In this review we focus on current knowledge of the reliability of tests and diagnostic criteria for generalized joint hypermobility (GJH) and benign joint hypermobility syndrome (BJHS)...
  71. ncbi How precise can bony landmarks be determined on a CT scan of the knee?
    J Victor
    AZ St Lucas, Brugge, Belgium
    Knee 16:358-65. 2009
    ..In the tibia, the best result is obtained for the tibial transverse axis...
  72. ncbi EQ-5D in patients with dementia: an investigation of inter-rater agreement
    W Coucill
    Health Economics Facility, University of Birmingham, England, UK
    Med Care 39:760-71. 2001
    ..There are difficulties in obtaining health-related quality of life (HRQL) data from patients with dementia due to variation in their cognitive ability, degree of insight and capacity to make judgments. The use of proxies is one solution...
  73. ncbi Direct T2 quantification of myocardial edema in acute ischemic injury
    David Verhaert
    The Ohio State University, Columbus, Ohio 43210, USA
    JACC Cardiovasc Imaging 4:269-78. 2011
    ..To evaluate the utility of rapid, quantitative T2 mapping compared with conventional T2-weighted imaging in patients presenting with various forms of acute myocardial infarction...
  74. ncbi Bright-blood T2-weighted MRI has higher diagnostic accuracy than dark-blood short tau inversion recovery MRI for detection of acute myocardial infarction and for assessment of the ischemic area at risk and myocardial salvage
    Alexander R Payne
    West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, Scotland, United Kingdom
    Circ Cardiovasc Imaging 4:210-9. 2011
    ..We compared the diagnostic accuracy of a new bright-blood T2-weighted with a standard black blood T2-weighted MRI in patients with acute MI...
  75. pmc Psychometric properties of the parent and teacher versions of the strengths and difficulties questionnaire for 4- to 12-year-olds: a review
    Lisanne L Stone
    Behavioural Science Institute, Radboud University Nijmegen, P O Box 9104, 6500 HE Nijmegen, The Netherlands
    Clin Child Fam Psychol Rev 13:254-74. 2010
    ..Longitudinal research studies should investigate predictive validity. For both practice and research, we emphasize the use of a multi-informant approach...
  76. ncbi Speckle-tracking echocardiography correctly identifies segmental left ventricular dysfunction induced by scarring in a rat model of myocardial infarction
    Zoran B Popovic
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 292:H2809-16. 2007
    ..0001) than on percent fibrosis (P<0.002). STE correctly identifies segmental LV dysfunction induced by scarring that follows myocardial infarction in rats...
  77. ncbi A randomised controlled trial of the efficacy of supervised toothbrushing in high-caries-risk children
    M M T Curnow
    Tayside NHS Primary Care Trust, Dental Department, Drumhar Health Centre, Perth, Scotland, UK
    Caries Res 36:294-300. 2002
    ..In conclusion, high-caries-risk children have been shown to have significantly less caries after participating in a supervised toothbrushing programme with a fluoridated toothpaste...
  78. pmc Variability in interpretation of chest radiographs among Russian clinicians and implications for screening programmes: observational study
    Y Balabanova
    Health Protection Agency National Mycobacterium Reference Unit, Department of Microbiology and Infection, Guy s, King s, and St Thomas Medical School, London
    BMJ 331:379-82. 2005
    ..To determine variability in interpretation of chest radiographs among tuberculosis specialists, radiologists, and respiratory specialists...
  79. ncbi Comparison of two-dimensional speckle and tissue velocity based strain and validation with harmonic phase magnetic resonance imaging
    Goo Yeong Cho
    Department of Medicine, University of Queensland, Brisbane, Australia
    Am J Cardiol 97:1661-6. 2006
    ..Nonetheless, epsilon2-D provides a reliable tool to quantify regional function, with radial measurements being more accurate and feasible than with TVI. Unlike epsilonTVI, epsilon2-D provides circumferential measurements...
  80. ncbi Accuracy of echocardiographic estimates of left ventricular mass in mice
    K A Collins
    Noninvasive Cardiac Imaging Laboratory, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Heart Circ Physiol 280:H1954-62. 2001
    ....
  81. pmc Reproducibility of MRI measurements of right ventricular size and function in patients with normal and dilated ventricles
    Christiaan F Mooij
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    J Magn Reson Imaging 28:67-73. 2008
    ..To determine the inter- and intraobserver reproducibility of cardiac magnetic resonance (CMR)-derived measurements of right ventricular (RV) mass, volume, and function in patients with normal and dilated ventricles...
  82. ncbi Proliferating cell nuclear antigen and Ki67 immunoreactivity in ameloblastomas
    Shabnum Meer
    University of the Witwatersrand, Division of Oral Pathology, Department of Anatomical Pathology, South Africa
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:213-21. 2003
    ....
  83. ncbi T2 relaxation time of cartilage at MR imaging: comparison with severity of knee osteoarthritis
    Timothy C Dunn
    Department of Radiology, University of California at San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94107 1739, USA
    Radiology 232:592-8. 2004
    ....
  84. ncbi Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
    E W Ely
    Department of Internal Medicine, Divisions of General Internal Medicine and Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 29:1370-9. 2001
    ..To develop and validate an instrument for use in the intensive care unit to accurately diagnose delirium in critically ill patients who are often nonverbal because of mechanical ventilation...
  85. ncbi Sonographic features of benign thyroid nodules: interobserver reliability and overlap with malignancy
    Jeffrey R Wienke
    Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Ultrasound Med 22:1027-31. 2003
    ..To prospectively determine the sonographic findings of nodular hyperplasia of the thyroid, to compare these with reported findings associated with malignancy, and to assess interobserver reliability...
  86. ncbi Consistency and precision of landmark identification in three-dimensional cone beam computed tomography scans
    Will Schlicher
    Division of Orthodontics, Department of Orofacial Sciences, School of Dentistry, University of California at San Francisco, San Francisco, CA 94143 0438, USA
    Eur J Orthod 34:263-75. 2012
    ..The most inconsistent landmark was porion-right (2.72 mm) and the most imprecise landmark was orbitale-right (1.81 mm). Due to the lack of even distribution of the errors, careful use of these landmarks for analysis purposes is needed...
  87. ncbi Intraobserver and interobserver agreement of the interpretation of pediatric chest radiographs
    Jeremiah Johnson
    Department of Emergency Medicine, Brooke Army Medical Center, 3851 Roger Brooke Dr, Fort Sam Houston San Antonio, TX, 78234, USA
    Emerg Radiol 17:285-90. 2010
    ..37 (0.25-0.51). Practicing emergency clinicians demonstrate considerable intraobserver and interobserver variability in the interpretation of pneumonia on pediatric chest radiographs...
  88. ncbi Prostate cancer: apparent diffusion coefficient map with T2-weighted images for detection--a multireader study
    Hyun Kyung Lim
    Department of Radiology, Asan Medical Center, University of Ulsan, 388 1 Poongnap dong, Songpa Gu, Seoul, 138 736, South Korea
    Radiology 250:145-51. 2009
    ....
  89. ncbi Interobserver agreement for sonograms of breast lesions obtained by an automated breast volume scanner
    Jing Zhang
    Department of Diagnostic Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China
    Eur J Radiol 81:2179-83. 2012
    ....
  90. pmc Variability of semiautomated lung nodule volumetry on ultralow-dose CT: comparison with nodule volumetry on standard-dose CT
    Patrick A Hein
    Department of Radiology, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117, Berlin, Germany
    J Digit Imaging 23:8-17. 2010
    ..Thus, the evaluated segmentation software provides nodule volumetry that appears to be independent of the dose level with which the CT source dataset is acquired...
  91. ncbi Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke
    J H Pexman
    Department of Clinical Neurosciences, Foothills Hospital, Calgary, Alberta, Canada
    AJNR Am J Neuroradiol 22:1534-42. 2001
    ..CONCLUSION: ASPECTS is a systematic, robust, and practical method that can be applied to different axial baselines. Clinician agreement is superior to that of the 1/3 MCA rule...
  92. ncbi The contribution of integrated PET/CT to the evolving definition of treatment volumes in radiation treatment planning in lung cancer
    Hani Ashamalla
    Department of Radiation Oncology, New York Methodist Hospital, Weill Medical College of Cornell University, Brooklyn, NY 11215, USA
    Int J Radiat Oncol Biol Phys 63:1016-23. 2005
    ....
  93. pmc Intraobserver and interobserver reproducibility in the evaluation of ultrasonic pachymetry measurements of central corneal thickness
    S Miglior
    Department of Ophthalmology, University of Milan Bicocca, Department of Neurosciences and Biomedical Technologies, Via Cadore 48, 20052 Monza, Milan, Italy
    Br J Ophthalmol 88:174-7. 2004
    ..To assess reproducibility of central corneal thickness (CCT) measurement by means of ultrasonic pachymetry...
  94. ncbi The Irvine-Minnesota inventory to measure built environments: reliability tests
    Marlon G Boarnet
    Department of Planning, Policy, and Design, University of California Irvine, Irvine, California, USA
    Am J Prev Med 30:153-159. 2006
    ..This paper presents results of reliability tests of the Irvine-Minnesota Inventory, an extensive audit tool aimed at measuring a broad range of built environment features that may be linked to active living...
  95. ncbi Interobserver variability in the CT assessment of honeycombing in the lungs
    Takeyuki Watadani
    Dept of Diagnostic Radiology, Saitama International Medical Ctr, Saitama Medical Univ, Hidaka, Saitama 3501298, Japan
    Radiology 266:936-44. 2013
    ..To quantify observer agreement and analyze causes of disagreement in identifying honeycombing at chest computed tomography (CT)...
  96. ncbi Fully automatic segmentation of white matter hyperintensities in MR images of the elderly
    F Admiraal-Behloul
    Department of Radiology, C2S, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Neuroimage 28:607-17. 2005
    ....
  97. ncbi Impact of papillary muscles in ventricular volume and ejection fraction assessment by cardiovascular magnetic resonance
    Burkhard Sievers
    Department of Cardiology and Angiology, University of Bochum, Hölkeskampring 40, D 44625 Herne, Germany
    J Cardiovasc Magn Reson 6:9-16. 2004
    ..Not subtracting the volumes of these structures enables faster determination of right and left ventricular volumes and ejection fractions without loss of the accuracy associated with the standard short-axis technique...
  98. ncbi Real-time 3-dimensional echocardiographic quantification of left ventricular volumes: multicenter study for validation with magnetic resonance imaging and investigation of sources of error
    Victor Mor-Avi
    University of Chicago Medical Center, Chicago, Illinois 60637, USA
    JACC Cardiovasc Imaging 1:413-23. 2008
    ....
  99. ncbi Improved aortic pulse wave velocity assessment from multislice two-directional in-plane velocity-encoded magnetic resonance imaging
    Jos J M Westenberg
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    J Magn Reson Imaging 32:1086-94. 2010
    ..To evaluate the accuracy and reproducibility of aortic pulse wave velocity (PWV) assessment by in-plane velocity-encoded magnetic resonance imaging (MRI)...
  100. ncbi Intra- and inter-observer reliability in anthropometric measurements in children
    S Stomfai
    Department of Paediatrics, Medical Faculty, University of Pecs, Hungary
    Int J Obes (Lond) 35:S45-51. 2011
    ..Therefore, it is important to confirm that body composition indices, which are subject to intra- and inter-individual variation, are measured using a standardised protocol that maximises their reliability and reduces error in analyses...
  101. ncbi Interobserver variability associated with the MIB-1 labeling index: high levels suggest limited prognostic usefulness for patients with primary brain tumors
    D M Grzybicki
    Department of Pathology and Laboratory Medicine, Allegheny General Hospital and MCP Hahnemann University, Pittsburgh, Pennsylvania 15212, USA
    Cancer 92:2720-6. 2001
    ..However, interobserver variability associated previously with MIB-1 LI calculation has not been reported despite the fact that the degree of interobserver variability impacts the clinical usefulness of such cut-off values...

Research Grants63

  1. Detection of Liver Fibrosis Using IVIM Diffusion and DCE MRI in HCV
    Bachir Taouli; Fiscal Year: 2013
    ..These techniques combined could reach high diagnostic performance for detection of liver fibrosis;and could decrease the number of necessary liver biopsies, which have risks and sample only a small portion of the liver. ..
  2. FOUR-DIMENSIONAL MRI FOR IMAGE-GUIDED RADIATION THERAPY FOR PANCREATIC CANCER
    Yanle Hu; Fiscal Year: 2013
    ..With reduced uncertainty in tumor location, shape and motion, we will be able to provide more conformal treatments, reducing radiation dose to normal tissues and thus the GI toxicity rate. ..
  3. Computer-Aided Detection of Pulmonary Embolism on CT Pulmonary Angiography
    Chuan Zhou; Fiscal Year: 2012
    ..CAD will potentially reduce missed PEs and improve the chance of timely treatment of patients, thus reducing the mortality rate and speed up recovery from this condition. ..
  4. Quantification of Regional Lung Disease by Computed Tomography
    Cuneyt Yilmaz; Fiscal Year: 2010
    ..End of Abstract) ..
  5. Accuracy of Breast Pathology and the Impact of Double Reading
    DONALD LEE WEAVER; Fiscal Year: 2013
    ..We will then evaluate methods for improving health care delivery using double reading. Finally, we will use a systematic method to make projections from our data to clinical implications of inaccurate diagnoses. ..
  6. Integrating Quantitative Histological Image and Vascular Density Patterns for Pro
    Anant Madabhushi; Fiscal Year: 2010
    ..Data accrual will be done at UPENN while algorithmic development for computerized image analysis and classification will be carried out at RU. ..
  7. Automating MRI Delta T1 Methods for the Routine Assessment of Brain Tumor Burden
    KATHLEEN MARIE SCHMAINDA; Fiscal Year: 2012
    ..This in turn can result in the performance of more efficient and cost-effective clinical trials, as well as improved care of patients on an individualized basis. ..
  8. Image Mining for Comparative Analysis of Expression Patterns in Tissue Microarray
    Joel H Saltz; Fiscal Year: 2013
    ....
  9. Fractional flow reserve measurement based on coronary angiographic images
    SABEE Y MOLLOI; Fiscal Year: 2010
    ..This quantification technique could be used to measure fractional flow reserve in patients undergoing standard coronary arteriography. ..
  10. Application of QDs-based nanotyping technology in the evaluation of chemotherapy
    Y Andrew Wang; Fiscal Year: 2010
    ..Moreover, IHC remains semi-quantitative and subjective, resulting in considerable inter-observer variation in results...
  11. Computerized Detection of Polyps in CT Colonography
    Hiroyuki Yoshida; Fiscal Year: 2009
    ..abstract_text> ..
  12. Intelligent and Automatic Image Segmentation Software for High ThroughputAnalysi
    Karyn Esser; Fiscal Year: 2013
    ....
  13. Novel Nanoscale Single-Cell Analysis of Exfoliative Cytology
    Yang Liu; Fiscal Year: 2013
    ..light microscope limis the detection of mostly micron-scale features of cancer cells, which result in intra-observer variation, missed early-stage cancers (false negatives), and indeterminate cases that often result in unnecessary ..
  14. QUANTITATIVE CORONARY ANGIOGRAPHY BY DUAL ENERGY DSA
    Sabee Molloi; Fiscal Year: 1993
    ..Furthermore, the basic data set from these quantitative techniques can potentially be utilized to derive more physiologically significant parameters such as absolute blood flow or coronary blood flow reserve...
  15. Computer-Aided Detection of Pulmonary Embolism on CT Pulmonary Angiography
    Chuan Zhou; Fiscal Year: 2007
    ..CAD will potentially reduce missed PEs and improve the chance of timely treatment of patients, thus reducing the mortality rate and speed up recovery from this condition. [unreadable] [unreadable]..
  16. THREE DIMENSIONAL CT COLONOGRAPHY
    Christopher Beaulieu; Fiscal Year: 2007
    ..abstract_text> ..
  17. STROKE OUTCOME AND NEUROIMAGING OF INTRACRANIAL STENOSIS
    Edward Feldmann; Fiscal Year: 2003
    ..SONIA will use these techniques to develop TCD or MRA cutpoints that minimize the clinical consequences of test errors that occur in the noninvasive evaluation of patients with suspected intracranial atherosclerosis. ..
  18. ULTRASOUND DETECTION AND STAGING OF PROSTATIC CANCER
    Joseph Smith; Fiscal Year: 1992
    ..A statistical and coordinating center has been established to record and analyze the results. Serum will be stored in a central bank and prostate specific antigen performed all on patients at a core laboratory...
  19. Pulmonary Lobar Analysis by 3D Surface Detection
    Juerg Tschirren; Fiscal Year: 2007
    ..The proposed methods are urgently needed to take advantage of emerging therapies for the early treatment of lung disease. [unreadable] [unreadable] [unreadable]..
  20. Quantification of Regional coronary Blood Flow
    Sabee Molloi; Fiscal Year: 2003
    ..This quantification technique could be used to measure regional myocardial perfusion in patients undergoing standard coronary arteriography. ..
  21. Perception and Inter-Observer Variability in Mammography
    Claudia Mello Thoms; Fiscal Year: 2005
    ..In addition, the changes in sampling strategy will correspond to actual possible strategies for the human observers themselves. ..
  22. COMPUTER AIDED DIAGNOSIS IN BREAST IMAGING
    Maryellen Giger; Fiscal Year: 2005
    ..We believe that with the combined information from multimodality imaging and clinical information, overall patient outcome will improve. ..
  23. AUTOMATED QUANTITATION OF 3D ECHOCARDIOGRAMS
    Richard Johnson; Fiscal Year: 2003
    ..This technology can be included in ultrasound systems or provided in workstations. The core technology can be applied to other organs and other imaging modalities. ..
  24. Vessel Segmentation/Registration from Ultrasound Images
    Sayan Pathak; Fiscal Year: 2003
    ..The goal of the Phase I study is to establish feasibility of the proposed methods by demonstrating an improvement in the repeatability and accuracy of measurements and reduction in delineation time. ..
  25. Reducing Benign Breast Biopsies with Computer Modeling
    Jay Baker; Fiscal Year: 2006
    ..Assuming performance approaching that of the preliminary model, a decision aid based on this model will be ready for prospective clinical trials at the conclusion of this project. ..
  26. Content based mammogram retrieval as a diagnostic aid
    MILES WERNICK; Fiscal Year: 2003
    ..abstract_text> ..
  27. PERCEPTUAL MODEL FOR WORKSTATION DISPLAY OPTIMIZATION
    Dev Chakraborty; Fiscal Year: 2003
    ..Also to be generated are iso-contour plots of the effects of common workstation variables on image quality in both tasks. This will allow digital mammography workstations to be more intelligently used. ..
  28. PERCEPTUAL MODEL FOR WORKSTATION DISPLAY OPTIMIZATION
    Dev Chakraborty; Fiscal Year: 2002
    ..Also to be generated are iso-contour plots of the effects of common workstation variables on image quality in both tasks. This will allow digital mammography workstations to be more intelligently used. ..
  29. Conference--Medical Image Perception
    Elizabeth Krupinski; Fiscal Year: 2003
    ..This grant will be used to provide financial support for about 12 graduate students and residents, as well as logistic support for publicity and program printing. ..
  30. The Cardiac Atlas Project: Establishment of a Cardiac MRI Database.
    ALISTAIR ANDREW YOUNG; Fiscal Year: 2010
    ..By pooling data from many studies into a single resource, researchers will be able to perform standardized comparisons across many patient groups, in order to better predict and evaluate the effects of disease and treatment. ..
  31. Optimized Compression for Telepathology Virtual Slides
    Elizabeth Krupinski; Fiscal Year: 2009
    ....
  32. MIPS XII Conference
    Elizabeth Krupinski; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. OPTIMIZING SOFTCOPY DISPLAYS FOR DIGITAL MAMMOGRAPHY
    Elizabeth Krupinski; Fiscal Year: 2002
    ..The JND metrix model will then be used to systematically explore and optimize CRT design tradeoffs for current and future digital-mammography display systems. ..
  34. Medical Image Perception Society Confrence XI
    Elizabeth Krupinski; Fiscal Year: 2005
    ..abstract_text> ..
  35. OPTIMIZING SOFTCOPY DISPLAYS FOR DIGITAL MAMMOGRAPHY
    Elizabeth Krupinski; Fiscal Year: 2003
    ..The JND metrix model will then be used to systematically explore and optimize CRT design tradeoffs for current and future digital-mammography display systems. ..
  36. The ODIE Toolkit - Software for Information Extraction and Biomedical Ontology De
    Rebecca S Crowley; Fiscal Year: 2010
    ..Additionally, the project would contribute to the software for developing other applications by helping researchers build more comprehensive ontologies. The results of this work may benefit both medical research and patient care. ..
  37. Capacity to Appoint a Proxy for Research Consent
    Scott Kim; Fiscal Year: 2009
    ..abstract_text> ..
  38. Enteric flora modulates the development of colitis
    Albert Jergens; Fiscal Year: 2008
    ..g., graduate students and postdoctoral fellow). There are ample opportunities to attend seminars, journal clubs and work-in-progress research meetings during which the applicant can become engaged in scientific discussions. ..
  39. PROGNOSIS OF CHILDREN WITH A FIRST UNPROVOKED SEIZURE
    Shlomo Shinnar; Fiscal Year: 2002
    ....
  40. Family Involvement /Resident Psychosocial Status in LTC
    JOSEPH GAUGLER; Fiscal Year: 2002
    ..abstract_text> ..
  41. EARLY VOCAL DEVELOPMENT IN YOUNG CHILDREN WITH COCHLEAR
    DAVID ERTMER; Fiscal Year: 2002
    ..18). ..
  42. An Automated System for Breast Cancer Biomarker Analysis
    John J Heine; Fiscal Year: 2010
    ..This work will produce a calibrated automated density assessment package that may be easily implemented across institutions without modifications for use in the FFDM systems that is tailored for tissue-related risk research. ..
  43. PHARYNGEAL AIRWAY FUNCTION
    SAMUEL KUNA; Fiscal Year: 2003
    ....
  44. Manipulating the Proteome
    Joshua Labaer; Fiscal Year: 2001
    ..The focus of this Center is to develop a toolkit of technologies that will enable the genome-scale study of protein function. ..
  45. b-catenin's role in establishing the gut stem cell niche
    Melissa Wong; Fiscal Year: 2009
    ..These proposed studies will directly examine the role of Wnt/beta-catenin signaling on maintenance of the stem cell niche and will shed insight into the regulatory control of intestinal stem cells. ..
  46. Caregiver Outcomes Post NH Placement of a Family Member
    JOSEPH GAUGLER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  47. Speech Production in Phonological Impairment
    Benjamin Munson; Fiscal Year: 2005
    ....
  48. Multiple Factors Affecting Placebo Response in PD
    Christopher Goetz; Fiscal Year: 2004
    ..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
  49. MMP-2 and MMP-9: Colorectal Cancer Diagnosis
    Mary Murnane; Fiscal Year: 2005
    ....
  50. A Novel Method for Determining Image Similarity
    Robert Nishikawa; Fiscal Year: 2006
    ..A reduction in the number of "unnecessary" biopsies will reduce cost, and physical and mental trauma to patients. [unreadable] [unreadable]..
  51. High-Performance Computer Cluster for Image Analysis
    Robert Nishikawa; Fiscal Year: 2007
    ....
  52. YFLEX: Saccharomyces cerevisiae ORF Clone Resource
    Joshua Labaer; Fiscal Year: 2004
    ..abstract_text> ..
  53. Molecular Dissection of Benign Prostatic Hyperplasia
    Mark Rubin; Fiscal Year: 2004
    ..b) Validation of tissue markers using MTOPS samples. Aim 4: Validation of candidate serum biomarkers of symptomatic BPH. a) Serum Microarray Validation using Michigan samples. b) Validation of serum markers using MTOPS samples. ..
  54. In search of the intestinal stem cell
    Melissa Wong; Fiscal Year: 2004
    ..These studies will determine if a signaling cascade is responsible for defining "stemness" or if a yet to be defined master regulator molecule directs synergy of the multiple pathways. ..
  55. Epidemiology of Carotid Intima-Medial Thickness (IMT) in Atherosclerosis
    Joseph Polak; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  56. Disability in Valued Life Activities in Persons with Rheumatoid Arthritis
    Patricia Katz; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  57. Multimodality CAD system with image references for breast mass characterization
    Berkman Sahiner; Fiscal Year: 2007
    ..Any reduction in this number without a decrease in breast cancer detection sensitivity will decrease health care costs, as well as contribute to the well-being of the patient by reducing anxiety and morbidity. ..
  58. Clinical Features in Nursing Home Residents with Suspected UTI
    Manisha Juthani Mehta; Fiscal Year: 2008
    ..This study will create an evidence-based definition of UTI. Future studies will identify residents with UTI in whom antibiotic therapy improves clinical outcome. [unreadable] [unreadable] [unreadable]..
  59. MRI Detection, Lateralization, and Quantification of Mesial Temporal Lobe Epileps
    Rotem Elgavish; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Low-cost, portable, computer assisted imaging for diabe*
    Michael Abramoff; Fiscal Year: 2008
    ..Our overall aim is to validate and optimize a low-cost, high quality, patient friendly imaging system for the early diagnosis of diabetic retinopathy. ..
  61. Computer mediated speech assessment in aphasia and AOS
    Katarina Haley; Fiscal Year: 2006
    ..These will include clinicians' and everyday listeners' ratings of speech severity, estimation of speaking rate, and frequency of errors identified on broad phonetic transcription. ..
  62. IRT and Psychological Disturbance in Young Offenders
    Gina Vincent; Fiscal Year: 2005
    ..Indirectly, findings will work toward advancing our misunderstanding of the nature and development of child psychopathology in general. ..
  63. Development of Improved Earphone for Hearing Testing
    Robert Margolis; Fiscal Year: 2008
    ..In this project an earphone is being developed that can be used in both automated and manual testing and will significantly increase the efficiency, accuracy, and accessibility. [unreadable] [unreadable] [unreadable]..