theta rhythm

Summary

Summary: One of four types of brain waves, characterized by a frequency of 4-7 Hz, usually observed in the temporal lobes when the individual is awake, but relaxed and sleepy.

Top Publications

  1. ncbi EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis
    W Klimesch
    Department of Physiological Psychology, Institute of Psychology, University of Salzburg, Hellbrunnerstr 34, A 5020, Salzburg, Austria
    Brain Res Brain Res Rev 29:169-95. 1999
  2. ncbi Frequency of gamma oscillations routes flow of information in the hippocampus
    Laura Lee Colgin
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, MTFS, Olav Kyrres gate 9, Norwegian University of Science and Technology, NO 7489 Trondheim, Norway
    Nature 462:353-7. 2009
  3. ncbi Theta burst stimulation of the human motor cortex
    Ying Zu Huang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuron 45:201-6. 2005
  4. ncbi Prefrontal phase locking to hippocampal theta oscillations
    Athanassios G Siapas
    Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Neuron 46:141-51. 2005
  5. pmc Memory, navigation and theta rhythm in the hippocampal-entorhinal system
    Gyorgy Buzsaki
    NYU Neuroscience Institute and Center for Neural Sciences, New York University, New York, New York, USA
    Nat Neurosci 16:130-8. 2013
  6. pmc An oscillatory interference model of grid cell firing
    Neil Burgess
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, United Kingdom
    Hippocampus 17:801-12. 2007
  7. pmc Reduction of theta rhythm dissociates grid cell spatial periodicity from directional tuning
    Mark P Brandon
    Center for Memory and Brain, Department of Psychology, Graduate Program for Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Science 332:595-9. 2011
  8. ncbi Mechanisms of gamma oscillations in the hippocampus of the behaving rat
    Jozsef Csicsvari
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
    Neuron 37:311-22. 2003
  9. pmc Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythm
    Anton Sirota
    Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
    Neuron 60:683-97. 2008
  10. ncbi The spatial periodicity of grid cells is not sustained during reduced theta oscillations
    Julie Koenig
    Neurobiology Section and Center for Neural Circuits and Behavior, Division of Biological Sciences, University of California, San Diego, USA
    Science 332:592-5. 2011

Detail Information

Publications261 found, 100 shown here

  1. ncbi EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis
    W Klimesch
    Department of Physiological Psychology, Institute of Psychology, University of Salzburg, Hellbrunnerstr 34, A 5020, Salzburg, Austria
    Brain Res Brain Res Rev 29:169-95. 1999
    ....
  2. ncbi Frequency of gamma oscillations routes flow of information in the hippocampus
    Laura Lee Colgin
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, MTFS, Olav Kyrres gate 9, Norwegian University of Science and Technology, NO 7489 Trondheim, Norway
    Nature 462:353-7. 2009
    ..The two types of gamma occurred at different phases of the CA1 theta rhythm and mostly on different theta cycles...
  3. ncbi Theta burst stimulation of the human motor cortex
    Ying Zu Huang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuron 45:201-6. 2005
    ....
  4. ncbi Prefrontal phase locking to hippocampal theta oscillations
    Athanassios G Siapas
    Computation and Neural Systems Program, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Neuron 46:141-51. 2005
    ..portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hippocampal theta rhythm. In addition, we show that prefrontal neurons phase lock best to theta oscillations delayed by approximately 50 ..
  5. pmc Memory, navigation and theta rhythm in the hippocampal-entorhinal system
    Gyorgy Buzsaki
    NYU Neuroscience Institute and Center for Neural Sciences, New York University, New York, New York, USA
    Nat Neurosci 16:130-8. 2013
    ..We review experimental data in support of this hypothesis and discuss how specific firing patterns and oscillatory dynamics in the entorhinal cortex and hippocampus can support both navigation and memory...
  6. pmc An oscillatory interference model of grid cell firing
    Neil Burgess
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, United Kingdom
    Hippocampus 17:801-12. 2007
    ..Predictions of the interference model are given for the frequency composition of EEG power spectra and temporal autocorrelograms of grid cell firing as functions of the speed and direction of running and the novelty of the environment...
  7. pmc Reduction of theta rhythm dissociates grid cell spatial periodicity from directional tuning
    Mark P Brandon
    Center for Memory and Brain, Department of Psychology, Graduate Program for Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA
    Science 332:595-9. 2011
    ..cortex of freely moving rats exhibit firing at regular spatial locations and temporal modulation with theta rhythm oscillations (4 to 11 hertz)...
  8. ncbi Mechanisms of gamma oscillations in the hippocampus of the behaving rat
    Jozsef Csicsvari
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
    Neuron 37:311-22. 2003
    ..CA3 pyramidal neurons discharged CA3 and CA1 interneurons at latencies indicative of monosynaptic connections. Intrahippocampal gamma oscillation emerges in the CA3 recurrent system, which entrains the CA1 region via its interneurons...
  9. pmc Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythm
    Anton Sirota
    Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
    Neuron 60:683-97. 2008
    ..as well as localized gamma oscillations in all recorded neocortical areas were phase biased by the hippocampal theta rhythm. We hypothesize that temporal coordination of neocortical gamma oscillators by hippocampal theta is a mechanism ..
  10. ncbi The spatial periodicity of grid cells is not sustained during reduced theta oscillations
    Julie Koenig
    Neurobiology Section and Center for Neural Circuits and Behavior, Division of Biological Sciences, University of California, San Diego, USA
    Science 332:592-5. 2011
    ..Precisely timed neural activity within single cells or local networks is thus required for periodic spatial firing but not for single place fields...
  11. ncbi Grid cells without theta oscillations in the entorhinal cortex of bats
    Michael M Yartsev
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 479:103-7. 2011
    ..Our results provide a direct demonstration of grid cells in a non-rodent species. Furthermore, they strongly argue against a major class of computational models of grid cells...
  12. pmc Theta-gamma coupling increases during the learning of item-context associations
    Adriano B L Tort
    Edmond and Lilly Safra International Institute of Neuroscience of Natal, Federal University of Rio Grande do Norte, RN 59066, Natal, Brazil
    Proc Natl Acad Sci U S A 106:20942-7. 2009
    ..Furthermore, the strength of theta-gamma coupling was directly correlated with the increase in performance accuracy during learning sessions. These findings suggest a role for hippocampal theta-gamma coupling in memory recall...
  13. pmc High gamma power is phase-locked to theta oscillations in human neocortex
    R T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Science 313:1626-8. 2006
    ..The results indicate that transient coupling between low- and high-frequency brain rhythms coordinates activity in distributed cortical areas, providing a mechanism for effective communication during cognitive processing in humans...
  14. ncbi Theta oscillations in the hippocampus
    Gyorgy Buzsaki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey and Neurological Institute of New Jersey, Newark, NJ 07102, USA
    Neuron 33:325-40. 2002
    ..Nevertheless, numerous critical issues regarding both the generation of theta oscillations and their functional significance remain challenges for future research...
  15. pmc Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop
    Kenji Mizuseki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    Neuron 64:267-80. 2009
    ..We hypothesize that the temporal windows set by the theta cycles allow for local circuit interactions and thus a considerable degree of computational independence in subdivisions of the EC-hippocampal loop...
  16. pmc Dual phase and rate coding in hippocampal place cells: theoretical significance and relationship to entorhinal grid cells
    John O'Keefe
    Department of Anatomy and Developmental Biology, University College London
    Hippocampus 15:853-66. 2005
    ..the hypothesis that hippocampal pyramidal cells encode information by their phase of firing relative to the theta rhythm of the EEG...
  17. ncbi The theta/gamma discrete phase code occuring during the hippocampal phase precession may be a more general brain coding scheme
    John Lisman
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Hippocampus 15:913-22. 2005
    ....
  18. ncbi Grid cells in pre- and parasubiculum
    Charlotte N Boccara
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, MTFS, Norwegian University of Science and Technology, Trondheim, Norway
    Nat Neurosci 13:987-94. 2010
    ..The symmetry of the grid pattern and its relationship to the theta rhythm were weaker, especially in presubiculum...
  19. pmc Grid cells and theta as oscillatory interference: theory and predictions
    Neil Burgess
    Institute of Cognitive Neuroscience, University College London
    Hippocampus 18:1157-74. 2008
    ..New analyses concern the relationships between the variables in the model and the theta rhythm, running speed, and the intrinsic firing frequencies of grid cells...
  20. ncbi Hippocampus-independent phase precession in entorhinal grid cells
    Torkel Hafting
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, NO 7489 Trondheim, Norway
    Nature 453:1248-52. 2008
    ..is a change in spike timing in which the place cell fires at progressively earlier phases of the extracellular theta rhythm as the animal crosses the spatially restricted firing field of the neuron...
  21. ncbi Theta and gamma oscillations during encoding predict subsequent recall
    Per B Sederberg
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 23:10809-14. 2003
    ..These findings implicate theta and gamma oscillatory activity, across a widespread network of cortical regions, in the formation of new episodic memories...
  22. ncbi Human memory strength is predicted by theta-frequency phase-locking of single neurons
    Ueli Rutishauser
    Computation and Neural Systems and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Nature 464:903-7. 2010
    ..These findings provide a link between the known modulation of theta oscillations by many memory-modulating behaviours and circuit mechanisms of plasticity...
  23. ncbi Phase precession and variable spatial scaling in a periodic attractor map model of medial entorhinal grid cells with realistic after-spike dynamics
    Zaneta Navratilova
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Alberta, Canada
    Hippocampus 22:772-89. 2012
    ..The model also exhibits independent variation in grid spatial period and grid field size, which suggests possible experimental tests of the model...
  24. ncbi A proposed function for hippocampal theta rhythm: separate phases of encoding and retrieval enhance reversal of prior learning
    Michael E Hasselmo
    Department of Psychology, Program in Neuroscience and Center for BioDynamics, Boston University, Boston, MA 02215, USA
    Neural Comput 14:793-817. 2002
    The theta rhythm appears in the rat hippocampal electroencephalogram during exploration and shows phase locking to stimulus acquisition...
  25. ncbi Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3TH, UK
    Nature 421:844-8. 2003
    ..We conclude that the diversity of interneurons, innervating distinct domains of pyramidal cells, emerged to coordinate the activity of pyramidal cells in a temporally distinct and brain-state-dependent manner...
  26. ncbi Frontal theta EEG activity correlates negatively with the default mode network in resting state
    Rene Scheeringa
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands
    Int J Psychophysiol 67:242-51. 2008
    ..we selected the component that best matched the mid-frontal scalp topography associated with the frontal theta rhythm. We applied a time-frequency analysis on this component and used the time course of the frequency bin with the ..
  27. ncbi Medial temporal theta/alpha power enhancement precedes successful memory encoding: evidence based on intracranial EEG
    Juergen Fell
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    J Neurosci 31:5392-7. 2011
    ....
  28. pmc Independent rate and temporal coding in hippocampal pyramidal cells
    John Huxter
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 425:828-32. 2003
    ..code takes the form of a phase relationship to the concurrent cycle of the hippocampal electroencephalogram theta rhythm. These two codes could each represent a different variable...
  29. ncbi Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm
    Ryan M Yoder
    Department of Psychology, J P Scott Center for Neuroscience, Mind and Behavior, Bowling Green State University, Bowling Green, Ohio 43403, USA
    Hippocampus 15:381-92. 2005
    Hippocampal theta rhythm (HPCtheta) may be important for various phenomena, including attention and acquisition of sensory information...
  30. ncbi Human theta oscillations related to sensorimotor integration and spatial learning
    Jeremy B Caplan
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 23:4726-36. 2003
    ..These findings suggest that human cortical oscillations act to coordinate sensory and motor brain activity in various brain regions to facilitate exploratory learning and navigational planning...
  31. pmc Cosine directional tuning of theta cell burst frequencies: evidence for spatial coding by oscillatory interference
    Adam C Welday
    Psychology Department, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 31:16157-76. 2011
    ..b>Theta rhythm commonly modulates the spike trains of spatially tuned neurons such as place (O'Keefe and Dostrovsky, 1971), ..
  32. pmc Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety
    Avishek Adhikari
    Department of Biological Sciences, Columbia University, New York, NY 10032, USA
    Neuron 65:257-69. 2010
    ..They are consistent with the notion that such synchronization is a general mechanism by which the hippocampus communicates with downstream structures of behavioral relevance...
  33. pmc Conversion of a phase- to a rate-coded position signal by a three-stage model of theta cells, grid cells, and place cells
    Hugh T Blair
    Psychology Department, University of California, Los Angeles, California 90095 1563, USA
    Hippocampus 18:1239-55. 2008
    ..theta oscillations, and we propose that such ring attractors may reside in subcortical areas where hippocampal theta rhythm is known to originate...
  34. ncbi Progressive increase in grid scale from dorsal to ventral medial entorhinal cortex
    Vegard Heimly Brun
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, Trondheim, Norway
    Hippocampus 18:1200-12. 2008
    ....
  35. pmc Grid cell firing may arise from interference of theta frequency membrane potential oscillations in single neurons
    Michael E Hasselmo
    Center for Memory and Brain and Program in Neuroscience, Boston University, Boston, Massachusetts, USA
    Hippocampus 17:1252-71. 2007
    ..frequency associated with speed of movement, about the independence of single cell properties from network theta rhythm oscillations, and about the effect of variations in initial oscillatory phase on the pattern of grid cell ..
  36. ncbi Brain oscillations and memory
    Emrah Duzel
    UCL Institute of Cognitive Neuroscience, University College London, WC1N 3AR London, United Kingdom
    Curr Opin Neurobiol 20:143-9. 2010
    ..This correspondence between species opens new perspectives for a mechanistic investigation of human memory function...
  37. pmc Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons
    Peer Wulff
    Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Proc Natl Acad Sci U S A 106:3561-6. 2009
    ..Hippocampal local field potential and unit recordings in the CA1 area of freely behaving mice revealed that theta rhythm was strongly reduced in these mice...
  38. ncbi Frontal theta activity in humans increases with memory load in a working memory task
    Ole Jensen
    Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, FIN 02015 HUT, Finland
    Eur J Neurosci 15:1395-9. 2002
    ..Following the memory task the theta activity was reduced. These results suggest that theta oscillations generated in frontal brain regions play an active role in memory maintenance...
  39. pmc Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus
    Caroline Geisler
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA
    Proc Natl Acad Sci U S A 107:7957-62. 2010
    ....
  40. pmc Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task
    Matthew W Jones
    The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Biol 3:e402. 2005
    ....
  41. ncbi Frontal-midline theta from the perspective of hippocampal "theta"
    Damon J Mitchell
    Department of Psychology and Centre for Neuroscience, University of Otago, Dunedin, New Zealand
    Prog Neurobiol 86:156-85. 2008
    ..The hippocampal "theta rhythm" has been extensively studied in rats and its rhythmicity has recently been shown to be functionally ..
  42. ncbi Gating of human theta oscillations by a working memory task
    S Raghavachari
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 21:3175-83. 2001
    ..These results suggest that theta oscillations could have an important role in organizing multi-item working memory...
  43. ncbi Fronto-parietal EEG coherence in theta and upper alpha reflect central executive functions of working memory
    Paul Sauseng
    Department of Physiological Psychology, University of Salzburg, Hellbrunnerstr 34, A 5020 Salzburg, Austria
    Int J Psychophysiol 57:97-103. 2005
    ....
  44. ncbi Medial prefrontal cortex cells show dynamic modulation with the hippocampal theta rhythm dependent on behavior
    James M Hyman
    Center for Memory and Brain, Department of Psychology, Boston University, Boston, MA 02215, USA
    Hippocampus 15:739-49. 2005
    ..Within the hippocampus the theta rhythm plays an integral role in the timing of action potentials of hippocampal neurons responding to elements of any ..
  45. ncbi Pacemaker neurons for the theta rhythm and their synchronization in the septohippocampal reciprocal loop
    Xiao Jing Wang
    Volen Center for Complex Systems, MS 013, Brandeis University, 415 South Street, Waltham, Massachusetts 02254 9110, USA
    J Neurophysiol 87:889-900. 2002
    ..other hand, experimental data indicate that GABAergic cells in the medial septum play a pacemaker role for the theta rhythm. We have used biophysical modeling to address two major questions raised by the septal pacemaker hypothesis: ..
  46. pmc Grid cells and theta as oscillatory interference: electrophysiological data from freely moving rats
    A Jeewajee
    Institute of Cognitive Neuroscience, University College London UCL, London, United Kingdom
    Hippocampus 18:1175-85. 2008
    ..They also provide specific constraints on this model of grid cell firing and have more general implications for viewing neuronal processing in terms of interfering oscillatory processes...
  47. ncbi Frontal midline EEG dynamics during working memory
    Julie Onton
    Swartz Center for Computational Neuroscience, Institute for Neural Computation, University of California San Diego, La Jolla, CA 92093 0961, USA
    Neuroimage 27:341-56. 2005
    ..Possibly, the observed fmtheta process variability may index dynamic adjustments in medial frontal cortex to trial-specific behavioral context and task demands...
  48. pmc Medial temporal theta state before an event predicts episodic encoding success in humans
    Sebastian Guderian
    Center for Advanced Imaging and Department of Neurology, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Proc Natl Acad Sci U S A 106:5365-70. 2009
    ..These findings provide insight into state-related aspects of memory formation in humans, and open a perspective for improving memory through theta-related brain states...
  49. ncbi A short review of slow phase synchronization and memory: evidence for control processes in different memory systems?
    Wolfgang Klimesch
    Department of Physiological Psychology, University of Salzburg, Austria
    Brain Res 1235:31-44. 2008
    ..The hypothesis, suggested here is that theta and upper alpha reflect these processes which can be best studied when analyzing phase...
  50. ncbi EEG oscillations and recognition memory: theta correlates of memory retrieval and decision making
    Joshua Jacobs
    Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroimage 32:978-87. 2006
    ..We also studied how these oscillatory dynamics complemented event-related potentials. These findings are the first to demonstrate that distinct patterns of theta oscillations can simultaneously relate to different aspects of behavior...
  51. ncbi Coherent theta-band EEG activity predicts item-context binding during encoding
    Christopher Summerfield
    Psychology Department, Columbia University, New York, NY 10027, USA
    Neuroimage 24:692-703. 2005
    ..Theta-band coherence may be an important mechanism by which brain networks exchange information during learning...
  52. ncbi Sharp edge artifacts and spurious coupling in EEG frequency comodulation measures
    Mark A Kramer
    Department of Mathematics and Statistics and Center for BioDynamics, Boston University, Boston, MA 02215, USA
    J Neurosci Methods 170:352-7. 2008
    ..In this short communication, we describe how abrupt increases or decreases in voltage data may produce spurious coupling in these measures and suggest techniques to detect these effects...
  53. ncbi In vitro activation of the medial septum-diagonal band complex generates atropine-sensitive and atropine-resistant hippocampal theta rhythm: an investigation using a complete septohippocampal preparation
    Romain Goutagny
    Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Hippocampus 18:531-5. 2008
    ..Although the importance of the MS-DB in hippocampal theta rhythm generation is generally accepted, it remains to be determined whether the MS-DB alone can generate hippocampal ..
  54. ncbi Phase segregation of medial septal GABAergic neurons during hippocampal theta activity
    Zsolt Borhegyi
    Department of Cellular and Network Neurobiology, Institute of Experimental Medicine of the Hungarian Academy of Science, Budapest 1083, Hungary
    J Neurosci 24:8470-9. 2004
    ....
  55. pmc Theta-modulated place-by-direction cells in the hippocampal formation in the rat
    Francesca Cacucci
    Department of Anatomy and Developmental Biology, University College London, WC1N 3AR, London, United Kingdom
    J Neurosci 24:8265-77. 2004
    ..When recorded in different environments, TPD locational and directional fields can uncouple, with the locational field shifting unpredictably ("remapping"), whereas the directional preference remains similar across environments...
  56. pmc Early alterations in hippocampal circuitry and theta rhythm generation in a mouse model of prenatal infection: implications for schizophrenia
    Guillaume Ducharme
    Douglas Mental Health University Institute, McGill University, Department of Psychiatry, Montreal, Quebec, Canada
    PLoS ONE 7:e29754. 2012
    ..Furthermore, given the role of theta rhythm in memory, our results demonstrate how a risk factor for schizophrenia can affect network function early in ..
  57. ncbi Keeping memory for intentions: a cTBS investigation of the frontopolar cortex
    Alberto Costa
    Laboratorio di Neurologia Clinica e Comportamentale, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Roma 00179, Italy
    Cereb Cortex 21:2696-703. 2011
    ..Our findings corroborate the hypothesis that within the prefrontal cortex, the left BA10 is specifically involved in the mediation of processes related to the execution of delayed intentions...
  58. ncbi Glutamatergic neurons of the mouse medial septum and diagonal band of Broca synaptically drive hippocampal pyramidal cells: relevance for hippocampal theta rhythm
    Carey Y L Huh
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 30:15951-61. 2010
    ..Our findings suggest that the glutamatergic septohippocampal pathway may play an important role in hippocampal theta oscillations and relevant cognitive functions...
  59. pmc Induction by kainate of theta frequency rhythmic activity in the rat medial septum-diagonal band complex in vitro
    Helen L Garner
    School of Biomedical Sciences, The Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    J Physiol 564:83-102. 2005
    ..septohippocampal pathway, is thought to be critical for the generation and/or maintenance of the hippocampal theta rhythm in vivo...
  60. pmc Theta phase classification of interneurons in the hippocampal formation of freely moving rats
    András Czurkó
    Department of Anatomy, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 31:2938-47. 2011
    ..Second, theta-modulated interneurons were further separated into four groups by the phase of the ∼8 Hz theta rhythm at which firing was most rapid...
  61. ncbi Dynamic brain sources of visual evoked responses
    S Makeig
    Computational Neurobiology Laboratory and, The Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, San Diego, CA 92037, USA
    Science 295:690-4. 2002
    ..Scalp topographies of these components were consistent with their generation in compact cortical domains...
  62. pmc Spiking neurons in a hierarchical self-organizing map model can learn to develop spatial and temporal properties of entorhinal grid cells and hippocampal place cells
    Praveen K Pilly
    Center for Adaptive Systems, Center for Computational Neuroscience and Neural Technology, Boston University, Boston, MA, USA
    PLoS ONE 8:e60599. 2013
    ....
  63. ncbi Theta band oscillation and synchrony in the hippocampal formation and associated structures: the case for its role in sensorimotor integration
    B H Bland
    Behavioral Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Behav Brain Res 127:119-36. 2001
    ..An updated version of the sensorimotor integration model including anatomical details is presented and discussed...
  64. ncbi Theta-band phase locking of orbitofrontal neurons during reward expectancy
    Marijn van Wingerden
    Cognitive and Systems Neuroscience Group, Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1090 GE Amsterdam, The Netherlands
    J Neurosci 30:7078-87. 2010
    ..Theta-band phase locking may facilitate communication of outcome-related information between reward-related brain areas and offers a novel mechanism for coding value signals during reinforcement learning...
  65. ncbi Syntactic processing modulates the theta rhythm of the human EEG
    Marcel C M Bastiaansen
    Max Planck Institute for Psycholinguistics, P O Box 310, 6500 AH Nijmegen, The Netherlands
    Neuroimage 17:1479-92. 2002
    ..Possible interpretations of this effect are considered in closing...
  66. pmc Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalography
    Brian R Cornwell
    Mood and Anxiety Disorders Program, NIMH, 15K North Dr, MSC 2670, Bethesda, MD 20892, USA
    Am J Psychiatry 167:836-44. 2010
    ..The authors aimed to link spatial navigation deficits previously documented in depressed patients to abnormal hippocampal functioning using a virtual reality navigation task...
  67. pmc Alteration of theta timescale dynamics of hippocampal place cells by a cannabinoid is associated with memory impairment
    David Robbe
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    J Neurosci 29:12597-605. 2009
    ..We hypothesize that precise temporal coordination of hippocampal neurons is necessary for guiding behavior in spatial memory tasks...
  68. pmc Behavior-dependent coordination of multiple theta dipoles in the hippocampus
    Sean M Montgomery
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 29:1381-94. 2009
    ..Moreover, our data suggest that these different theta generators flexibly coordinate hippocampal regions and layers to support behavioral task performance...
  69. pmc Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivo
    Hao Zhang
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 30:13431-40. 2010
    ..These findings also suggest that phasic ACh is not required for theta initiation and may instead operate synergistically with theta oscillations to promote neural plasticity in the service of learning and memory...
  70. pmc Distinct representations and theta dynamics in dorsal and ventral hippocampus
    Sebastien Royer
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurosci 30:1777-87. 2010
    ..This change is paralleled with a reduction of theta rhythm and an increased representation of nonspatial information.
  71. ncbi Effects of theta burst stimulation protocols on phosphene threshold
    Michele Franca
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Clin Neurophysiol 117:1808-13. 2006
    ....
  72. pmc Ketamine disrupts θ modulation of γ in a computer model of hippocampus
    Samuel A Neymotin
    State University of New York Downstate New York University Poly Joint Biomedical Engineering Program, Brooklyn, New York 11201, USA
    J Neurosci 31:11733-43. 2011
    ..We suggest that this last prediction has implications for a possible novel treatment for cognitive deficits of schizophrenia by targeting OLM cells...
  73. pmc Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum
    Colin Lever
    Behavioural Neuroscience Lab, Institute of Psychological Sciences, University of Leeds, Leeds, United Kingdom
    Hippocampus 20:229-34. 2010
    ..A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases...
  74. ncbi Frontal midline theta rhythm is correlated with cardiac autonomic activities during the performance of an attention demanding meditation procedure
    Y Kubota
    Department of Neuropsychiatry, Faculty of Medicine, Kyoto University, Shogoin Kawaharacho, 606 8507, Kyoto, Japan
    Brain Res Cogn Brain Res 11:281-7. 2001
    Frontal midline theta rhythm (Fm theta), recognized as distinct theta activity on EEG in the frontal midline area, reflects mental concentration as well as meditative state or relief from anxiety...
  75. ncbi Theta EEG dynamics of the error-related negativity
    Logan T Trujillo
    Department of Psychology, University of Arizona, Tucson, AZ 85721 0068, USA
    Clin Neurophysiol 118:645-68. 2007
    ....
  76. ncbi Self-generated theta oscillations in the hippocampus
    Romain Goutagny
    Douglas Mental Health University Institute, McGill University, Department of Psychiatry, Quebec, Canada
    Nat Neurosci 12:1491-3. 2009
    Hippocampal theta rhythm is crucial for spatial memory and is thought to be generated by extrinsic inputs. In contrast, using a complete rat hippocampus in vitro, we found several intrinsic, atropine-resistant theta generators in CA1...
  77. ncbi Human theta oscillations exhibit task dependence during virtual maze navigation
    M J Kahana
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 399:781-4. 1999
    ..Theta oscillations occur more frequently in more complex mazes; they are also more frequent during recall trials than during learning trials...
  78. ncbi Coupling of theta oscillations between anterior and posterior midline cortex and with the hippocampus in freely behaving rats
    Calvin K Young
    Department of Psychology, University of Otago, Dunedin 9054, New Zealand
    Cereb Cortex 19:24-40. 2009
    ....
  79. ncbi What is the function of hippocampal theta rhythm?--Linking behavioral data to phasic properties of field potential and unit recording data
    Michael E Hasselmo
    Department of Psychology, Center for Memory and Brain, Program in Neuroscience, Boston University, Boston, MA 02215, USA
    Hippocampus 15:936-49. 2005
    The extensive physiological data on hippocampal theta rhythm provide an opportunity to evaluate hypotheses about the role of theta rhythm for hippocampal network function...
  80. pmc Prediction, sequences and the hippocampus
    John Lisman
    Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Philos Trans R Soc Lond B Biol Sci 364:1193-201. 2009
    ..The mechanism of sequence retrieval and the usefulness of this retrieval to guide behaviour are discussed...
  81. ncbi Cross-frequency phase synchronization: a brain mechanism of memory matching and attention
    Paul Sauseng
    Department of Psychology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, Austria
    Neuroimage 40:308-17. 2008
    ..We conclude that memory information is stored within a distributed theta network and it is matched with an incoming sensory trace at posterior brain areas...
  82. ncbi Theta synchronization and alpha desynchronization in a memory task
    W Klimesch
    Department of Physiological Psychology, University of Salzburg, Austria
    Psychophysiology 34:169-76. 1997
    ..In contrast to the theta band, remembered and not remembered words revealed a complex pattern of desynchronization in the lower and upper alpha band that was different during encoding and recognition...
  83. ncbi Mode shifting between storage and recall based on novelty detection in oscillating hippocampal circuits
    M Meeter
    Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands
    Hippocampus 14:722-41. 2004
    ..It is shown that this is compatible with the time scale on which memory processes take place. A number of strong predictions regarding memory function are derived from the model...
  84. ncbi The functional significance of theta and upper alpha oscillations
    Wolfgang Klimesch
    Department of Physiological Psychology, University of Salzburg, Austria
    Exp Psychol 52:99-108. 2005
    ..We suggest that theta reflects working memory functions whereas upper alpha may be important for the reactivation of long-term memory codes in short-term memory...
  85. pmc Theta-burst repetitive transcranial magnetic stimulation suppresses specific excitatory circuits in the human motor cortex
    V Di Lazzaro
    Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, Rome, Italy
    J Physiol 565:945-50. 2005
    ....
  86. ncbi Brain oscillations and human memory: EEG correlates in the upper alpha and theta band
    W Klimesch
    University of Salzburg, Department of Physiological Psychology, Institute of Psychology, Austria
    Neurosci Lett 238:9-12. 1997
    ..Even when the influence of episodic memory was removed by partial correlations, a reliable association between upper alpha desynchronization and semantic memory was observed...
  87. ncbi Event-related alpha and theta responses in a visuo-spatial working memory task
    Marcel C M Bastiaansen
    Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands
    Clin Neurophysiol 113:1882-93. 2002
    ..To explore the reactivity of the theta and alpha rhythms during visuo-spatial working memory...
  88. ncbi Hippocampal CA1 spiking during encoding and retrieval: relation to theta phase
    Joseph R Manns
    Center for Memory and Brain, Boston University, Boston, MA 02215, USA
    Neurobiol Learn Mem 87:9-20. 2007
    The hippocampal theta rhythm is a prominent oscillation in the field potential observed throughout the hippocampus as a rat investigates stimuli in the environment. A recent computational model [Hasselmo, M. E., Bodelon, C...
  89. ncbi Sleep-dependent theta oscillations in the human hippocampus and neocortex
    Jose L Cantero
    Laboratory of Neurophysiology, Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:10897-903. 2003
    ....
  90. pmc Gap junctions between interneurons are required for normal spatial coding in the hippocampus and short-term spatial memory
    Kevin Allen
    Department of Clinical Neurobiology, Heidelberg University and German Cancer Research Center, 69120 Heidelberg, Germany
    J Neurosci 31:6542-52. 2011
    ..Moreover, they suggest that the precise spatial selectivity of place cells is not essential for normal performance on spatial tasks assessing associative long-term memory...
  91. ncbi Hippocampo-cerebellar theta band phase synchrony in rabbits
    J Wikgren
    Department of Psychology, University of Jyvaskyla, Jyvaskyla, Finland
    Neuroscience 165:1538-45. 2010
    ..Future studies should examine cerebellar unit activity in relation to hippocampal theta oscillations in order to discover the detailed mechanisms of theta-paced neural activity...
  92. ncbi Behavioral correlates of human hippocampal delta and theta oscillations during navigation
    Andrew J Watrous
    Center for Neuroscience, University of California, Davis, 1544 Newton Court, Davis, CA 95618, USA
    J Neurophysiol 105:1747-55. 2011
    ..These results extend previous findings in nonhuman mammals and humans, expanding our knowledge of the role of human hippocampal low-frequency oscillations in navigation...
  93. ncbi Septal networks: relevance to theta rhythm, epilepsy and Alzheimer's disease
    Luis V Colom
    Department of Biological Sciences, Center of Biomedical Studies, University of Texas at Brownsville Texas Southmost College, Brownsville, TX 78520, USA
    J Neurochem 96:609-23. 2006
    ..Septal neurons not only provide the optimal levels of excitatory background to cortical structures, but they may also inhibit the occurrence of abnormal excitability states...
  94. ncbi Decreased rhythmic GABAergic septal activity and memory-associated theta oscillations after hippocampal amyloid-beta pathology in the rat
    Vincent Villette
    Inserm Centre de Psychiatrie et Neurosciences, Unité Mixte de Recherche 894, 75014 Paris, France
    J Neurosci 30:10991-1003. 2010
    ..in the firing of the identified rhythmic bursting GABAergic neurons responsible for the propagation of the theta rhythm to the hippocampus, but without loss of medial septal neurons...
  95. ncbi Theta oscillations reflect the dynamics of interference in episodic memory retrieval
    Tobias Staudigl
    Department of Experimental Psychology, Regensburg University, 93053 Regensburg, Germany
    J Neurosci 30:11356-62. 2010
    ..Thus, theta band activity can serve as a neural marker of the dynamics of interference in selective episodic retrieval...
  96. pmc Adolescent changes in homeostatic regulation of EEG activity in the delta and theta frequency bands during NREM sleep
    Ian G Campbell
    University of California Davis, Department of Psychiatry and Behavioral Sciences, Davis, CA 95618, USA
    Sleep 34:83-91. 2011
    ..We used longitudinal data to determine whether these homeostatic dynamics change across adolescence...
  97. pmc Computational study of hippocampal-septal theta rhythm changes due to β-amyloid-altered ionic channels
    Xin Zou
    Intelligent Systems Research Centre, University of Ulster Magee Campus, Derry, Northern Ireland, United Kingdom
    PLoS ONE 6:e21579. 2011
    ..channel can induce an increase in hippocampo-septal theta band power, while the other channels do not affect theta rhythm. We further deduce that this increased theta band power is due to enhanced synchrony of the pyramidal neurons...
  98. ncbi Phase locking of single neuron activity to theta oscillations during working memory in monkey extrastriate visual cortex
    Han Lee
    Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, D 72076 Tubingen, Germany
    Neuron 45:147-56. 2005
    ....
  99. pmc Cerebellar theta oscillations are synchronized during hippocampal theta-contingent trace conditioning
    Loren C Hoffmann
    Department of Psychology and Center for Neuroscience, Miami University, 90 North Patterson Avenue, Oxford, OH 45056, USA
    Proc Natl Acad Sci U S A 106:21371-6. 2009
    ....
  100. ncbi Phase-locked alpha and theta oscillations generate the P1-N1 complex and are related to memory performance
    Wolfgang Klimesch
    Department of Physiological Psychology, University of Salzburg, Institute of Psychology, Hellbrunnerstr 34, A 5020 Salzburg, Austria
    Brain Res Cogn Brain Res 19:302-16. 2004
    ..Our general conclusion is that the P1-N1 complex is generated primarily by evoked alpha and theta oscillations reflecting the synchronous activation of a working- and semantic memory system...
  101. ncbi h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy
    Béatrice Marcelin
    INSERM U751, Universite de la Mediterranee, 27, Bd Jean Moulin, 13005 Marseille, France
    Neurobiol Dis 33:436-47. 2009
    ..We suggest that the neuronal/circuitry changes associated with TLE, including altered I(h)-dependent inductive mechanisms, can disrupt hippocampal theta function...

Research Grants62

  1. CIRCUITRY CONTROLLING THE HIPPOCAMPAL THETA RHYTHM
    ROBERT VERTES; Fiscal Year: 2002
    ..nucleus (SUM) is a critical relay between the brainstem and septum hippocampus in the control of the theta rhythm. The proposed studies are divided into two parts; those done with and without collaborators...
  2. CRCNS: Path Intergration by the Grid Cell Network
    Kechen Zhang; Fiscal Year: 2013
    ..In rats, one particular kind of oscillation referred to as "theta rhythm" is very predominant in the hippocampus and entorhinal cortex, brain areas that play a critical role in ..
  3. Temporally precise control of theta oscillations
    Stefan Leutgeb; Fiscal Year: 2013
    ..It has been suggested that the hippocampal theta rhythm provides temporal control for neuronal firing patterns that support memory processes, but this can only be ..
  4. Signaling by cAMP within Postsynaptic Nanodomains
    Johannes W Hell; Fiscal Year: 2013
    ..2, or both are important for regulation of a form of LTP induced by a tetanus of 5 Hz (endogenous theta rhythm) for 180 s that requires stimulation of the ? AR and Cav1.2 activity...
  5. Synchronous Activity in Hybrid Neuronal Microcircuits
    John A White; Fiscal Year: 2013
    ..gap for a problem of great relevance in cognition and learning and memory: the cellular bases of the coherent theta rhythm in the hippocampus...
  6. Mechanisms of Entorhinal Cortex Function
    Michael E Hasselmo; Fiscal Year: 2013
    ..of firing will be analyzed for theta cycle skipping and theta phase precession relative to entorhinal theta rhythm oscillations, for the interaction of entorhinal rhythmic activity with hippocampal rhythmic activity in the ..
  7. Simulation of learning: models and biological validation
    Michel Baudry; Fiscal Year: 2012
    ..to incorporate cholinergic modulation of CA1 network function in order to better understand the links between theta rhythm synchronization of neuronal firing and LTP formation, as well as various types of metabotropic glutamate ..
  8. Pathophysiology of the septo-hippocampal glutamatergic system
    Luis V Colom; Fiscal Year: 2011
    ..and is crucial to the initiation and occurrence of rhythmical cortical activities such as the hippocampal theta rhythm which plays an important role in processing sensory information and memory...
  9. CRCNS: Phase resetting predicts synchronization in hybrid hippocampal circuits
    CARMEN CASTRO CANAVIER; Fiscal Year: 2010
    ..Specific Aim 2. Test the hypothesis that N:1 locking between the gamma and theta rhythm aligns the firing of local oriens-lacunosum moleculare (O-LM) interneurons with that of a gamma cycle, with a ..
  10. Memory encoding and retrieval: Ethanol modulation of theta reset
    BENNET S GIVENS; Fiscal Year: 2011
    ..The 5-92 Hz electrophysiological oscillation recorded in the mammalian brain called the theta rhythm has consistently been shown to coordinate the flow of memory-bound stimulus information into the hippocampus...
  11. Effects of Ethanol on Hippocampal Activity during Learning
    Myles J Ketchum; Fiscal Year: 2013
    ..Additionally, we will characterize shifts in the phase of neural unit activity within the hippocampal theta rhythm cycle...
  12. LONG-TERM DEPRESSION IN HIPPOCAMPAL INTERNEURONS
    JULIE KAUER; Fiscal Year: 1999
    ..example of a change in overall hippocampal excitability is the shift from desynchronized activity to theta rhythm observed in hippocampal EEG recordings...
  13. MECHANISMS OF DEVELOPMENTAL LEAD NEUROTOXICITY
    JANUSZ SUSZKIW; Fiscal Year: 1999
    ..septohippocampal pathway will be assessed by measuring changes in the atropine-sensitive, type 2 hippocampal theta rhythm. Patch clamp recordings from acutely isolated septal neurons will be employed to analyze the effect of in vivo ..
  14. CELLULAR PHARMACOLOGY AND PHYSIOLOGY OF SEPTAL NEURONS
    JOEL GALLAGHER; Fiscal Year: 1993
    ..our original hypothesis that the DLSN may serve as site for the induction, maintenance, and expression of theta rhythm. This study will test four hypotheses which suggest cellular mechanisms to explain the induction of theta ..
  15. CA CHANNELS IN THALAMIC & HIPPOCAMPAL RHYTHMIC ACTIVITY
    Matthew Anderson; Fiscal Year: 2004
    ..EEG recordings of the hippocampus have revealed that behavioral exploration is marked by theta rhythm, while slow wave sleep and awake immobility are marked by synchronous rhythmic bursts called sharp wave/ripple ..
  16. COGNITIVE AND REWARD MECHANISMS IN OPIATE ADDICTION
    Jose Criado; Fiscal Year: 2000
    ..heroin on PPT- and VTA-induced modulation of perforant path-to-dentate responses and their induction of dentate theta rhythm. To determine the roles of the PPT and VTA on heroin-induced changes in dentate activity, this study will ..
  17. BRAINSTEM MODULATION OF THE HIPPOCAMPUS
    ROBERT VERTES; Fiscal Year: 1993
    ..of cells within the pontine reticular formation (PRF) of the rat with activity highly correlated with the theta rhythm of the hippocampus...
  18. CRCNS - Neuromodulation of Hippocampal Synaptic Plasticity in Waking & REM Sleep
    Gina Poe; Fiscal Year: 2007
    ..Cells with place fields in an initially novel environment switch from firing near the theta rhythm peaks to firing near the theta troughs during REM, while maintaining their theta peak activity during waking ..
  19. NEURAL BASIS OF INTERNAL REPRESENTATION OF PLACE
    Bruce McNaughton; Fiscal Year: 2009
    ..critically on the generation of precise spike timing relationships relative to the local EEG oscillations (theta rhythm)...
  20. Cooperation among subcortical networks underlying memory
    Bernat Kocsis; Fiscal Year: 2005
    ..patterns but also to build dynamic associations between several limbic structures that are synchronized by the theta rhythm. Extrahippocampal theta activity has been recently described in a number of structures under urethane ..
  21. BRAIN MECHANISMS, TIMING AND TEMPORAL MEMORY
    WARREN MECK; Fiscal Year: 1992
    ..by choline uptake in the hippocampus and frontal cortex and patterns of electrical activity as measured by theta rhythm in these same areas will be examined as possible indices of the magnitude and direction of temporal memory ..
  22. NEURAL BASIS OF INTERNAL REPRESENTATION OF PLACE
    Bruce McNaughton; Fiscal Year: 2007
    ..through the "place field" of a given pyramidal ('place') cell, the cell begins firing late in the theta rhythm cycle and the firing phase shifts progressively earlier as the rat runs through the field (a phenomenon known ..
  23. Characterization of CA 1 hippocampal interneuron LTD
    Jeffrey Edwards; Fiscal Year: 2005
    ..response can result in run-away activity causing epilepsy, while increased activity eliminates the hippocampal theta rhythm, which is absent in Alzheimer's patients...
  24. Neuromodulation and Neuronal Dynamics
    John White; Fiscal Year: 2004
    ..mechanisms underlying two EEG rhythms that appear together during active exploration and learning: the 4-12 Hz theta rhythm and 30-80 Hz gamma rhythm...
  25. Dynamics and Control of Neuronal Pattern Formation
    Steven Schiff; Fiscal Year: 2007
    ..and 4) to apply insights gained from modeling to design and test rational control strategies for seizures and theta rhythm in In Vitro and In Vivo experiments...
  26. Dynamics and Control of Neuronal Pattern Formation
    Steven Schiff; Fiscal Year: 2007
    ..insights gained from the compartmental model to design and test rational control strategies for seizures and theta rhythm in In Vitro and In Vivo experiments...
  27. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2006
    ..will generate clear experimental predictions about the timing of spikes relative o behavior and relative to theta rhythm EEG based on hypotheses about the physiological interaction. [unreadable] 3...
  28. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
    ..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
  29. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2007
    ..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
  30. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
    ....
  31. MBRS SCORE Program at the Univ of Texas-Brownsville
    LUIS COLOM; Fiscal Year: 2007
    ..Furthermore, the success of this application will contribute to the development of internal collaborations and the necessary scientific environment to develop successful R01 applications in the near future. ..
  32. Hemispheric Lateralization of Emotional Memory Circuits in the Amygdala
    HUGH BLAIR; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Multiple Memory Systems in Action Selection
    JOSHUA BERKE; Fiscal Year: 2005
    ..abstract_text> ..
  34. Mechanisms of Basal Forebrain Neurodegeneration
    LUIS COLOM; Fiscal Year: 2004
    ..Data from this work may contribute to the development of specific therapies designed to decrease neuronal dysfunction and vulnerability in AD. Furthermore, this work will contribute to our understanding of basal forebrain physiology. ..
  35. MOP Receptor Effects on the Hippocampal CA1 Network
    ADAM MCQUISTON; Fiscal Year: 2008
    ..The results from these studies will provide important information regarding MOP receptor-induced changes in network activity and may possibly lead to the development of treatments for opioid addiction. ..
  36. CRCNS-Multiple olfactory gamma oscillations: roles in sensation and attention
    Leslie Kay; Fiscal Year: 2008
    ..We anticipate that understanding how olfactory deficits arise from changes in the limbic system associated with many of these disorders, will help us to understand the mechanisms that produce cognitive malfunctioning. ..
  37. Subcortical Estrogen Effect on The Hippocampus
    Csaba Leranth; Fiscal Year: 2005
    ..cholinergic and GABAergic septo-hippocampal neurons involved in mediating estrogenic effect to the hippocampus? and (d) Do SUM neurons mediate estrogenic effect to the hippocampus directly or indirectly, via the MSDB? ..
  38. Negative Effects of Bisphenol A on the Monkey CNS
    Csaba Leranth; Fiscal Year: 2008
    ..Therefore, we propose to reveal the effect of BPA on estrogen-induced spine synapse formation in the brain of non-human primates, which will provide more relevance to human health. [unreadable] [unreadable] [unreadable]..
  39. Genetics of EEG Patterns in ADHD
    Sandra K Loo; Fiscal Year: 2010
    ..We are thus able to collect EEG data at a very low cost in a well characterized sample of ADHD ASPs upon which linkage studies (and candidate gene association work) are readily available. ..
  40. Imaging Local Network Activity in Vivo
    Gyorgy Buzsaki; Fiscal Year: 2006
    ..The electric field-unit imaging methods developed and tested in the hippocampus can be applied for other cortical and subcortical structures. ..
  41. Estrogenic Effect on Hippocampal Theta Rhythm and Memory
    Csaba Leranth; Fiscal Year: 2004
    ....
  42. Genetic Underpinnings of EEG Patterns in ADHD
    Sandra Loo; Fiscal Year: 2006
    ..Given the applicant's prior training, proposed mentorship, and outstanding resources, a K23 Award will enable her to become an independent and productive researcher in the genetics and developmental neuropsychology of ADHD. ..
  43. AUTOMATIC ELICITATION OF COGNITIVE ERP COMPONENTS
    Judith Ford; Fiscal Year: 2001
    ..By combining ERP and fMRI methods we will characterize the spatio-tumoral dynamics of the neuroanatomic circuit(s) involved in normal and abnormal response monitoring. ..
  44. Developing New Skills for Mouse Neurogenetics Research
    WAYNE FRANKEL; Fiscal Year: 2004
    ..We request funds to support the travel and lodging of two Visiting Investigators and two Students at any given time, plus the supplies, animal care resources and faculty salary required to support these activities. ..
  45. Electrophysiological Action of GHB in Brain Reward Areas
    Vincenzo Crunelli; Fiscal Year: 2003
    ....
  46. 8th Sleep and Breathing Symposium
    Leszek Kubin; Fiscal Year: 2002
    ..abstract_text> ..
  47. Liability Markers for Deficit Schizophrenia?
    L Hong; Fiscal Year: 2004
    ..We plan to use the preliminary data collected from this grant support to guide our full-scale search for phenotypic markers specifically associated with the liability for deficit schizophrenia and subsequent molecular genetic studies. ..
  48. NRT & Bupropion Mechanisms of Efficacy in Smokers
    David G Gilbert; Fiscal Year: 2010
    ..Note,* To avoid final-session mood and arousal effects subjects will actually quit for 67 days, but biobehavioral measures will be collected on the 66 day of abstinence ..
  49. NEURAL SUBSTRATES OF ADAPTIVE JAW MOVEMENT
    Stephen Berry; Fiscal Year: 2004
    ..Characterization of the brainstem neurobehavioral control systems and their modulation by the forebrain will provide a necessary foundation for the application of this model system to health-related research. ..
  50. Kainate Receptors on Hippocampal Interneurons
    Matthew Frerking; Fiscal Year: 2007
    ..abstract_text> ..
  51. Intracranial Mapping of Sensory Gating in Humans
    Nashaat Boutros; Fiscal Year: 2006
    ..These data will shed more light on this crucial function and will help further our understanding of the mechanisms that lead to the development of psychotic disorders. ..
  52. Attentional Bias & Affect in Stress-Vulnerable Smokers
    David Gilbert; Fiscal Year: 2007
    ..An EEG stress response index (alpha asymmetry) will be used in a subgroup of subjects during each of the 3 proposed studies. ..
  53. EPISODIC HYPOXIA, HYPOTHALAMUS AND INSULIN RESISTANCE
    Leszek Kubin; Fiscal Year: 2007
    ..The proposed experiments will provide a comprehensive assessment of the relationship between IH and the central mechanisms of insulin resistance, and evaluate the potential for therapeutic interventions. [unreadable] [unreadable]..
  54. Brainstem-Diencephalic Modulation of the Hippocampus
    ROBERT VERTES; Fiscal Year: 2006
    ..that the nucleus pontis oralis (RPO) and the median raphe nucleus are directly involved in the synchronization (theta rhythm) and desynchronization of the hippocampal EEG, respectively, and that the suprammillary nucleus serves as a ..
  55. Third International Workshop on Seizure Prediction - Freiburg, Germany, 2007
    Hitten Zaveri; Fiscal Year: 2007
    ..Investigators whose participation will be supported will be invited speakers and junior and senior investigators including women and racial and ethnic minorities. [unreadable] [unreadable] [unreadable]..
  56. Electrophysiology: Integrating Modalities and Discipline
    Nashaat Boutros; Fiscal Year: 2008
    ..Both career awards and travel grants will be offered for young investigators to attend the conference. This is again designed to facilitate the interaction between established and new investigators. [unreadable] [unreadable]..
  57. Plasticity of motor cortical preferred directions
    Beata Jarosiewicz; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  58. PHASE RESETTING AND SENSORY INHIBITION IN THE CNS
    Nashaat Boutros; Fiscal Year: 2005
    ....
  59. Nicotine: Cognition-Affect Interactions
    David Gilbert; Fiscal Year: 2005
    ..The new knowledge derived from these studies will be useful in developing empirical model-based treatment strategies aimed at increasing smoking abstinence. ..
  60. GTReal Workshop: Real-Time Methods in Electrophysiology
    John White; Fiscal Year: 2006
    ..Real-time techniques also have the potential to revolutionize systems physiology and behavioral studies of sensory systems. [unreadable] [unreadable] [unreadable]..