mass screening

Summary

Summary: Organized periodic procedures performed on large groups of people for the purpose of detecting disease.

Top Publications

  1. ncbi Effect of screening and adjuvant therapy on mortality from breast cancer
    Donald A Berry
    Department of Biostatistics and Applied Mathematics, M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 353:1784-92. 2005
  2. doi Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
    Bernard Levin
    The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Gastroenterology 134:1570-95. 2008
  3. ncbi The Patient Health Questionnaire-2: validity of a two-item depression screener
    Kurt Kroenke
    Regenstrief Institute for Health Care and Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
    Med Care 41:1284-92. 2003
  4. doi Cancer screening in the United States, 2010: a review of current American Cancer Society guidelines and issues in cancer screening
    Robert A Smith
    Cancer Control Science Department, American Cancer Society, Atlanta, GA 30303, USA
    CA Cancer J Clin 60:99-119. 2010
  5. ncbi Against which human papillomavirus types shall we vaccinate and screen? The international perspective
    Nubia Munoz
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 111:278-85. 2004
  6. ncbi Screening for serious mental illness in the general population
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Suite 215, Boston, MA 02115, USA
    Arch Gen Psychiatry 60:184-9. 2003
  7. pmc Effectiveness of yearly, register based screening for chlamydia in the Netherlands: controlled trial with randomised stepped wedge implementation
    Ingrid V F van den Broek
    Unit of Epidemiology and Surveillance, RIVM Centre for Infectious Disease Control Netherlands, PO Box 1, 3720 BA Bilthoven, Netherlands
    BMJ 345:e4316. 2012
  8. pmc Effectiveness of cervical screening with age: population based case-control study of prospectively recorded data
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
    BMJ 339:b2968. 2009
  9. ncbi Overview of the European and North American studies on HPV testing in primary cervical cancer screening
    Jack Cuzick
    Cancer Research UK, Wolfson Institute of Preventive Medicine, London
    Int J Cancer 119:1095-101. 2006
  10. doi Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial
    Dorien C Rijkaart
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Oncol 13:78-88. 2012

Detail Information

Publications377 found, 100 shown here

  1. ncbi Effect of screening and adjuvant therapy on mortality from breast cancer
    Donald A Berry
    Department of Biostatistics and Applied Mathematics, M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 353:1784-92. 2005
    ..We used modeling techniques to assess the relative and absolute contributions of screening mammography and adjuvant treatment to the reduction in breast-cancer mortality in the United States from 1975 to 2000...
  2. doi Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
    Bernard Levin
    The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Gastroenterology 134:1570-95. 2008
    ..It is the strong opinion of these 3 organizations that colon cancer prevention should be the primary goal of screening...
  3. ncbi The Patient Health Questionnaire-2: validity of a two-item depression screener
    Kurt Kroenke
    Regenstrief Institute for Health Care and Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
    Med Care 41:1284-92. 2003
    ..Because even briefer measures might be desirable for use in busy clinical settings or as part of comprehensive health questionnaires, we evaluated a 2-item version of the PHQ depression module, the PHQ-2...
  4. doi Cancer screening in the United States, 2010: a review of current American Cancer Society guidelines and issues in cancer screening
    Robert A Smith
    Cancer Control Science Department, American Cancer Society, Atlanta, GA 30303, USA
    CA Cancer J Clin 60:99-119. 2010
    ....
  5. ncbi Against which human papillomavirus types shall we vaccinate and screen? The international perspective
    Nubia Munoz
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 111:278-85. 2004
    ..The impact of modifying the number of types in the screening cocktail tests would be small and probably irrelevant for screening programs...
  6. ncbi Screening for serious mental illness in the general population
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Suite 215, Boston, MA 02115, USA
    Arch Gen Psychiatry 60:184-9. 2003
    ..Public Law 102-321 established a block grant for adults with "serious mental illness" (SMI) and required the Substance Abuse and Mental Health Services Administration (SAMHSA) to develop a method to estimate the prevalence of SMI...
  7. pmc Effectiveness of yearly, register based screening for chlamydia in the Netherlands: controlled trial with randomised stepped wedge implementation
    Ingrid V F van den Broek
    Unit of Epidemiology and Surveillance, RIVM Centre for Infectious Disease Control Netherlands, PO Box 1, 3720 BA Bilthoven, Netherlands
    BMJ 345:e4316. 2012
    ..To evaluate the effectiveness of register based, yearly chlamydia screening...
  8. pmc Effectiveness of cervical screening with age: population based case-control study of prospectively recorded data
    Peter Sasieni
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Bart s and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ
    BMJ 339:b2968. 2009
    ..To study the effect of cervical screening on incidence of cervical cancer as a function of age with particular focus on women screened under the age of 25...
  9. ncbi Overview of the European and North American studies on HPV testing in primary cervical cancer screening
    Jack Cuzick
    Cancer Research UK, Wolfson Institute of Preventive Medicine, London
    Int J Cancer 119:1095-101. 2006
    ..These results support the use of HPV testing as the sole primary screening test, with cytology reserved for women who test HPV positive. Large demonstration projects are needed to fully evaluate this strategy...
  10. doi Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial
    Dorien C Rijkaart
    Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Oncol 13:78-88. 2012
    ..The aim of this study was to assess whether HPV DNA testing in the first screen decreases detection of cervical intraepithelial neoplasia (CIN) grade 3 or worse, CIN grade 2 or worse, and cervical cancer in the second screening...
  11. pmc Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies
    Haileyesus Getahun
    World Health Organization, Geneva, Switzerland
    PLoS Med 8:e1000391. 2011
    ..We conducted an individual participant data meta-analysis of primary studies, aiming to identify a sensitive TB screening rule...
  12. ncbi Risk-based selection from the general population in a screening trial: selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON)
    Carola A Van Iersel
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Int J Cancer 120:868-74. 2007
    ..When pooling with Danish trial data (n = +/-4,000) NELSON is the only trial without screening in controls that is expected to have 80% power to show a lung cancer mortality reduction of at least 25% 10 years after randomisation...
  13. doi HPV screening for cervical cancer in rural India
    Rengaswamy Sankaranarayanan
    International Agency for Research on Cancer, Lyon, France
    N Engl J Med 360:1385-94. 2009
    ....
  14. doi Epidemiology and prevention of human papillomavirus and cervical cancer in sub-Saharan Africa: a comprehensive review
    Karly S Louie
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Trop Med Int Health 14:1287-302. 2009
    ..To identify the gaps of knowledge and highlight the challenges and opportunities for controlling cervical cancer in sub-Saharan Africa (SSA)...
  15. pmc Screening for breast cancer: an update for the U.S. Preventive Services Task Force
    Heidi D Nelson
    Oregon Health and Science University, Veterans Affairs Medical Center, Portland, OR 97239 3098, USA
    Ann Intern Med 151:727-37, W237-42. 2009
    ..This systematic review is an update of evidence since the 2002 U.S. Preventive Services Task Force recommendation on breast cancer screening...
  16. ncbi Expanding access to voluntary HIV counselling and testing in sub-Saharan Africa: alternative approaches for improving uptake, 2001-2007
    Joseph K B Matovu
    Rakai Health Sciences Program Uganda Virus Research Institute, Entebbe, Uganda
    Trop Med Int Health 12:1315-22. 2007
    ..We recommend that these alternative models be implemented in more settings and on a much larger scale in sub-Saharan Africa, where VCT uptake rates remain low...
  17. pmc Examining the promise of HIV elimination by 'test and treat' in hyperendemic settings
    Peter J Dodd
    Imperial College London, London, UK
    AIDS 24:729-35. 2010
    ....
  18. pmc Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up
    Gerald L Andriole
    Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Natl Cancer Inst 104:125-32. 2012
    ..Mortality after 7-10 years of follow-up has been reported previously. We report extended follow-up to 13 years after the trial...
  19. doi Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial
    Guglielmo Ronco
    Centre for Cancer Prevention, Turin, Italy
    Lancet Oncol 11:249-57. 2010
    ..We assessed the efficacy of cervical-cancer screening policies that are based on HPV testing...
  20. doi Depression screening and patient outcomes in cardiovascular care: a systematic review
    Brett D Thombs
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    JAMA 300:2161-71. 2008
    ..Several practice guidelines recommend that depression be evaluated and treated in patients with cardiovascular disease, but the potential benefits of this are unclear...
  21. doi Screening for colorectal cancer: randomised trial comparing guaiac-based and immunochemical faecal occult blood testing and flexible sigmoidoscopy
    L Hol
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre Rotterdam, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Gut 59:62-8. 2010
    ..We conducted a randomised trial comparing participation and detection rates (DR) per screenee of guaiac-based faecal occult blood test (gFOBT), immunochemical FOBT (FIT), and flexible sigmoidoscopy (FS) for CRC screening...
  22. doi Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (hemoccult): an update
    Paul Hewitson
    Department of Primary Health Care, University of Oxford, Oxford, United Kingdom
    Am J Gastroenterol 103:1541-9. 2008
    ....
  23. pmc Incidence of diabetic retinopathy in people with type 2 diabetes mellitus attending the Diabetic Retinopathy Screening Service for Wales: retrospective analysis
    R L Thomas
    Diabetes Research Unit, Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff CF14 4XW, UK
    BMJ 344:e874. 2012
    ..To determine the incidence of any and referable diabetic retinopathy in people with type 2 diabetes mellitus attending an annual screening service for retinopathy and whose first screening episode indicated no evidence of retinopathy...
  24. doi Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on
    Judith H Lichtman
    Circulation 118:1768-75. 2008
    ..This multispecialty consensus document reviews the evidence linking depression with CHD and provides recommendations for healthcare providers for the assessment, referral, and treatment of depression...
  25. pmc American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer
    Debbie Saslow
    Cancer Control Science Department, American Cancer Society, Atlanta, GA 30303, USA
    CA Cancer J Clin 62:147-72. 2012
    ....
  26. doi Screening and prostate-cancer mortality in a randomized European study
    Fritz H Schroder
    Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands
    N Engl J Med 360:1320-8. 2009
    ..The European Randomized Study of Screening for Prostate Cancer was initiated in the early 1990s to evaluate the effect of screening with prostate-specific-antigen (PSA) testing on death rates from prostate cancer...
  27. ncbi Human papillomavirus and Papanicolaou tests to screen for cervical cancer
    Pontus Naucler
    Department of Medical Microbiology, Malmo University Hospital, Lund University, Malmo, Sweden
    N Engl J Med 357:1589-97. 2007
    ....
  28. pmc Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective study
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS Med 8:e1001067. 2011
    ..However, its utility for routine TB screening and detection of rifampicin resistance among HIV-infected patients with advanced immunodeficiency enrolling in antiretroviral therapy (ART) services is unknown...
  29. pmc Screening and case-finding instruments for depression: a meta-analysis
    Simon Gilbody
    Department of Health Sciences and Hull York Medical School, University of York, United Kingdom
    CMAJ 178:997-1003. 2008
    ..We sought to establish the effectiveness of screening in improving the recognition of depression, the management of depression and the outcomes of patients with depression...
  30. ncbi ESPEN guidelines for nutrition screening 2002
    J Kondrup
    Rigshospitalet University Hospital, Copenhagen, Denmark
    Clin Nutr 22:415-21. 2003
    ..In order to reach this goal the Education and Clinical Practice Committee invites and welcomes all criticism and suggestions (button for mail to ECPC chairman)...
  31. doi The prevalence of celiac disease in Europe: results of a centralized, international mass screening project
    Kirsi Mustalahti
    Paediatric Research Centre, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Ann Med 42:587-95. 2010
    ....
  32. doi Overview of human papillomavirus-based and other novel options for cervical cancer screening in developed and developing countries
    Jack Cuzick
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, United Kingdom
    Vaccine 26:K29-41. 2008
    ..These psychosocial aspects and the need for more information and educational programmes about HPV are also discussed in this article...
  33. doi Overdiagnosis in cancer
    H Gilbert Welch
    Department of Veterans Affairs Medical Center, White River Junction, VT 05009, USA
    J Natl Cancer Inst 102:605-13. 2010
    ..Equally important, researchers need to work to develop better estimates of the magnitude of overdiagnosis and develop clinical strategies to help minimize it...
  34. doi Prevalence of Chlamydia trachomatis: results from the first national population-based survey in France
    V Goulet
    Institut de Veille Sanitaire, 12 Rue du Val d Osne, Saint Maurice 94410, France
    Sex Transm Infect 86:263-70. 2010
    ..Few studies have estimated Chlamydia trachomatis (CT) prevalence in the general population, most prevalence studies being based on people already attending healthcare settings...
  35. doi Asia Pacific consensus recommendations for colorectal cancer screening
    J J Y Sung
    The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Gut 57:1166-76. 2008
    ..There is no consensus on whether nurses should be trained to perform endoscopic procedures for screening of colorectal neoplasia...
  36. pmc Mortality results from a randomized prostate-cancer screening trial
    Gerald L Andriole
    Washington University School of Medicine, St Louis, USA
    N Engl J Med 360:1310-9. 2009
    ..This is the first report from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial on prostate-cancer mortality...
  37. pmc Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial
    Simon J Griffin
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Lancet 378:156-67. 2011
    ..Intensive treatment of multiple cardiovascular risk factors can halve mortality among people with established type 2 diabetes. We investigated the effect of early multifactorial treatment after diagnosis by screening...
  38. ncbi Behavioral counseling interventions in primary care to reduce risky/harmful alcohol use by adults: a summary of the evidence for the U.S. Preventive Services Task Force
    Evelyn P Whitlock
    Oregon Evidence Based Practice Center, Kaiser Permanente Center for Health Research, and Oregon Health and Science University, Portland, Oregon 97227 1110, USA
    Ann Intern Med 140:557-68. 2004
    ..Primary health care visits offer opportunities to identify and intervene with risky or harmful drinkers to reduce alcohol consumption...
  39. doi Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology
    Bernard Levin
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 58:130-60. 2008
    ..It is the strong opinion of these 3 organizations that colon cancer prevention should be the primary goal of screening...
  40. pmc Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis
    Albert E Chudley
    Children s Hospital, Health Sciences Centre, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Man
    CMAJ 172:S1-S21. 2005
    ..These are the first Canadian guidelines for the diagnosis of FAS and its related disabilities, developed by broad-based consultation among experts in diagnosis...
  41. pmc Overdiagnosis in screening mammography in Denmark: population based cohort study
    Sisse Helle Njor
    Department of Public Health, University of Copenhagen, Østre Farimagsgade 5, DK 1014 Copenhagen K, Denmark
    BMJ 346:f1064. 2013
    ..To use data from two longstanding, population based screening programmes to study overdiagnosis in screening mammography...
  42. doi Approaches to tuberculosis screening and diagnosis in people with HIV in resource-limited settings
    Michael J A Reid
    Department of Social Medicine, Montefiore Medical Center, Bronx, NY 10467, USA
    Lancet Infect Dis 9:173-84. 2009
    ..However, until simpler, cheaper, and more sensitive diagnostics for tuberculosis are available in peripheral healthcare settings, a strategy must be developed that uses current evidence to combine available screening tools...
  43. ncbi AUDIT-C as a brief screen for alcohol misuse in primary care
    Katharine A Bradley
    Health Services Research and Development, VA Puget Sound Health Care System, Seattle, WA 98101, USA
    Alcohol Clin Exp Res 31:1208-17. 2007
    ..However, the AUDIT-C's validity and optimal screening threshold(s) in other clinical populations are unknown...
  44. ncbi Screening for dementia in primary care: a summary of the evidence for the U.S. Preventive Services Task Force
    Malaz Boustani
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Ann Intern Med 138:927-37. 2003
    ..Dementia is a large and growing problem but is often not diagnosed in its earlier stages. Screening and earlier treatment could reduce the burden of suffering of this syndrome...
  45. pmc Economic evaluation of human papillomavirus vaccination in the United Kingdom
    Mark Jit
    Modelling and Economics Unit, Centre for Infections, Health Protection Agency, London NW9 6BT
    BMJ 337:a769. 2008
    ..To assess the cost effectiveness of routine vaccination of 12 year old schoolgirls against human papillomavirus infection in the United Kingdom...
  46. doi Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model
    Reuben M Granich
    Department of HIV AIDS, WHO, Geneva, Switzerland
    Lancet 373:48-57. 2009
    ..We investigated a theoretical strategy of universal voluntary HIV testing and immediate treatment with ART, and examined the conditions under which the HIV epidemic could be driven towards elimination...
  47. ncbi Breast density as a predictor of mammographic detection: comparison of interval- and screen-detected cancers
    M T Mandelson
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    J Natl Cancer Inst 92:1081-7. 2000
    ..Cancers diagnosed after a negative mammogram are known as interval cancers. This study investigated whether mammographic breast density is related to the risk of interval cancer...
  48. doi American Cancer Society guideline for the early detection of prostate cancer: update 2010
    Andrew M D Wolf
    University of Virginia School of Medicine, Charlottesville, VA, USA
    CA Cancer J Clin 60:70-98. 2010
    ..Patient decision aids are helpful in preparing men to make a decision whether to be tested...
  49. pmc Community screening and treatment of asymptomatic carriers of Plasmodium falciparum with artemether-lumefantrine to reduce malaria disease burden: a modelling and simulation analysis
    Steven E Kern
    Department of Pharmaceutics, University of Utah, Salt Lake City, Utah, USA
    Malar J 10:210. 2011
    ..Identification and treatment of asymptomatic carriers within a region may reduce the parasite reservoir and influence malaria transmission in that area...
  50. ncbi Longitudinal measurement of clinical mammographic breast density to improve estimation of breast cancer risk
    Karla Kerlikowske
    Department of Epidemiology and Biostatistics, Department of Veterans Affairs, University of California, San Francisco, CA, USA
    J Natl Cancer Inst 99:386-95. 2007
    ..Whether a change over time in clinically measured mammographic breast density influences breast cancer risk is unknown...
  51. ncbi The effect of fecal occult-blood screening on the incidence of colorectal cancer
    J S Mandel
    Exponent, Menlo Park, Calif 94025, USA
    N Engl J Med 343:1603-7. 2000
    ..However, the effect of screening on the incidence of colorectal cancer remains uncertain, despite the diagnosis and removal of precancerous lesions in many persons who undergo screening...
  52. ncbi Cost-effectiveness of screening for HIV in the era of highly active antiretroviral therapy
    Gillian D Sanders
    Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    N Engl J Med 352:570-85. 2005
    ..The costs, benefits, and cost-effectiveness of screening for human immunodeficiency virus (HIV) in health care settings during the era of highly active antiretroviral therapy (HAART) have not been determined...
  53. doi Opt-out HIV testing during antenatal care: experiences of pregnant women in rural Uganda
    Elin C Larsson
    Division of Global Health IHCAR, Department of Public Health Sciences, Karolinska Institutet, Nobelsv 9, 171 77, Stockholm, Sweden
    Health Policy Plan 27:69-75. 2012
    ..Moreover, to achieve the desired outcomes of the PMTCT programme, monitoring and evaluation should be built into the programme...
  54. pmc Incentivized recruitment of a population sample to a mobile HIV testing service increases the yield of newly diagnosed cases, including those in need of antiretroviral therapy
    K Kranzer
    Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK
    HIV Med 13:132-7. 2012
    ....
  55. pmc Missed opportunities for HIV testing and late-stage diagnosis among HIV-infected patients in Uganda
    Rhoda K Wanyenze
    Department of Disease Control and Environmental Health, Makerere University School of Public Health, Kampala, Uganda
    PLoS ONE 6:e21794. 2011
    ..We provided HIV testing to patients at Mulago hospital in Uganda, and performed CD4 tests to assess disease stage at diagnosis...
  56. pmc Integrating HIV screening into routine health care in resource-limited settings
    Ingrid V Bassett
    Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 50:S77-84. 2010
    ..We review the benefits of knowledge of HIV serostatus and evidence from multiple countries surrounding the successes and pitfalls of provider-initiated testing in health care and home-based settings...
  57. ncbi Early Lung Cancer Action Project: overall design and findings from baseline screening
    C I Henschke
    Weill Medical College of Cornell University and New York Presbyterian Hospital, NY 10021, USA
    Lancet 354:99-105. 1999
    ..The Early Lung Cancer Action Project (ELCAP) is designed to evaluate baseline and annual repeat screening by low-radiation-dose computed tomography (low-dose CT) in people at high risk of lung cancer. We report the baseline experience...
  58. pmc Entry screening to delay local transmission of 2009 pandemic influenza A (H1N1)
    Benjamin J Cowling
    School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    BMC Infect Dis 10:82. 2010
    ..After the WHO issued the global alert for 2009 pandemic influenza A (H1N1), many national health agencies began to screen travelers on entry in airports, ports and border crossings to try to delay local transmission...
  59. doi Age-specific evaluation of primary human papillomavirus screening vs conventional cytology in a randomized setting
    Maarit Leinonen
    Mass Screening Registry, Finnish Cancer Registry, Pieni Roobertinkatu 9, FI 00130 Helsinki, Finland
    J Natl Cancer Inst 101:1612-23. 2009
    ..We compared the age-specific performance of primary HPV DNA screening with that of conventional cytology screening in the setting of an organized population-based cervical cancer screening program in Finland...
  60. doi Transmission dynamics of Chlamydia trachomatis affect the impact of screening programmes
    Christian L Althaus
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
    Epidemics 2:123-31. 2010
    ..However, due to the slower turnover of the infection, a substantial reduction in prevalence can only be achieved after screening for several years or decades...
  61. doi Randomized controlled trial of proactive web-based alcohol screening and brief intervention for university students
    Kypros Kypri
    School of Medicine and Public Health, David Maddison Clinical Sciences Bldg, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Arch Intern Med 169:1508-14. 2009
    ..We tested the efficacy of a proactive Web-based alcohol screening and brief intervention program...
  62. doi Routine opt-out rapid HIV screening and detection of HIV infection in emergency department patients
    Jason S Haukoos
    Department of Emergency Medicine, Denver Health Medical Center, Denver, Colorado, USA
    JAMA 304:284-92. 2010
    ..1% or greater. The utility of this approach in EDs remains unknown...
  63. ncbi Screening for depression in adults: a summary of the evidence for the U.S. Preventive Services Task Force
    Michael P Pignone
    University of North Carolina Hospitals, Chapel Hill, USA
    Ann Intern Med 136:765-76. 2002
    ..To clarify whether screening adults for depression in primary care settings improves recognition, treatment, and clinical outcomes...
  64. doi Self-collection of vaginal specimens for human papillomavirus testing in cervical cancer prevention (MARCH): a community-based randomised controlled trial
    Eduardo Lazcano-Ponce
    Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Lancet 378:1868-73. 2011
    ..We aimed to establish the relative sensitivity and positive predictive value for HPV screening of vaginal samples self-collected at home as compared with clinic-based cervical cytology...
  65. pmc A decision aid to support informed choices about bowel cancer screening among adults with low education: randomised controlled trial
    Sian K Smith
    Screening and Test Evaluation Program, Centre for Medical Psychology and Evidence Based Decision Making, Sydney School of Public Health, University of Sydney, NSW 2006, Australia
    BMJ 341:c5370. 2010
    ..To determine whether a decision aid designed for adults with low education and literacy can support informed choice and involvement in decisions about screening for bowel cancer...
  66. pmc Screening for depression in primary care with two verbally asked questions: cross sectional study
    Bruce Arroll
    Department of General Practice and Primary Health Care, Faculty of Medical and Health Sciences, University of Auckland, PB 92019, Auckland, New Zealand
    BMJ 327:1144-6. 2003
    ..To determine the diagnostic accuracy of two verbally asked questions for screening for depression...
  67. doi Modest public health impact of nontargeted human immunodeficiency virus screening in 29 emergency departments
    Kayigan Wilson d'Almeida
    Institut national de la santé et de la recherche médicale Inserm U1018, Centre de Recherche en Epidémiologie et Santé des Populations, Villejuif, France
    Arch Intern Med 172:12-20. 2012
    ..We assessed the public health impact of nontargeted HIV-rapid test (RT) screening among ED patients in the metropolitan area of Paris (11.7 million inhabitants), where half of France's new HIV cases are diagnosed annually...
  68. pmc Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): a diagnostic meta-analysis
    Simon Gilbody
    Department of Health Sciences, University of York, York, YO10 5DD, UK
    J Gen Intern Med 22:1596-602. 2007
    ..To summarize the psychometric properties of the PHQ2 and PHQ9 as screening instruments for depression...
  69. ncbi Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence
    Sidney Winawer
    Gastroenterology 124:544-60. 2003
    ..Improvement depends on changes in patients' attitudes, physicians' behaviors, insurance coverage, and the surveillance and reminder systems necessary to support screening programs...
  70. doi Comparing participation rates between immunochemical and guaiac faecal occult blood tests: a systematic review and meta-analysis
    Gemma Vart
    Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK
    Prev Med 55:87-92. 2012
    ..The aim of this study was to review studies comparing guaiac faecal occult blood tests and faecal immunochemical tests, in terms of participation rates...
  71. pmc Screening for prostate cancer: systematic review and meta-analysis of randomised controlled trials
    Mia Djulbegovic
    Department of Urology and Prostate Disease Center, University of Florida, College of Medicine, PO Box 100247, Gainesville, Florida 32610 0247, USA
    BMJ 341:c4543. 2010
    ..To examine the evidence on the benefits and harms of screening for prostate cancer...
  72. pmc Intensive tuberculosis screening for HIV-infected patients starting antiretroviral therapy in Durban, South Africa
    Ingrid V Bassett
    Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Infect Dis 51:823-9. 2010
    ..Our objective was to assess the yield and cost of a more intensive tuberculosis screening in HIV-infected patients starting antiretroviral therapy (ART) in Durban, South Africa...
  73. pmc Comparison of breast and bowel cancer screening uptake patterns in a common cohort of South Asian women in England
    Charlotte L Price
    Warwick Medical School, University of Warwick, Coventry, UK
    BMC Health Serv Res 10:103. 2010
    ..This paper compares breast and bowel cancer screening uptake for a cohort of South Asian women invited to undertake both, and similarly investigates these women's breast cancer screening behaviour over a period of fifteen years...
  74. doi A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China
    You Lin Qiao
    Cancer Institute, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, China
    Lancet Oncol 9:929-36. 2008
    ..5 h, to screen women in developing regions for cervical intraepithelial neoplasia (CIN). We did a cross-sectional study to assess the clinical accuracy of careHPV as a rapid screening test in two county hospitals in rural China...
  75. ncbi Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends
    Ruth Etzioni
    Program in Biostatistics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 94:981-90. 2002
    ..Overdiagnosis was defined as the detection of prostate cancer through PSA testing that otherwise would not have been diagnosed within the patient's lifetime...
  76. pmc Modelling the effectiveness of chlamydia screening in England
    K M E Turner
    Health Protection Agency, Centre for Infections, 61 Colindale Ave, Colindale, London NW9 5EQ, UK
    Sex Transm Infect 82:496-502. 2006
    ..Mathematical models can incorporate these non-linear effects and estimate the likely impact of different screening programmes and identify areas where more data are needed...
  77. ncbi Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings
    Bernard M Branson
    Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention proposed, Atlanta, GA 30333, USA
    MMWR Recomm Rep 55:1-17; quiz CE1-4. 2006
    ..Repeat screening in the third trimester is recommended in certain jurisdictions with elevated rates of HIV infection among pregnant women...
  78. ncbi Contextual analysis of breast and cervical cancer screening and factors associated with health care access among United States women, 2002
    Steven S Coughlin
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Soc Sci Med 66:260-75. 2008
    ..A significant interaction was also observed between the percentage of county female population who were Hispanic and the percentage who were non-Hispanic Black...
  79. ncbi Randomized controlled trial of screening for hepatocellular carcinoma
    Bo Heng Zhang
    Liver Cancer Institute of Fudan University, Zhongshan Hospital, 180 Feng Lin Road, Shanghai 200032, China
    J Cancer Res Clin Oncol 130:417-22. 2004
    ..The aim of this study was to assess the effect of screening on HCC mortality in people at increased risk...
  80. pmc Opt-out provider-initiated HIV testing and counselling in primary care outpatient clinics in Zambia
    Stephanie M Topp
    Centre for Infectious Disease Research in Zambia, Lusaka, Zambia
    Bull World Health Organ 89:328-335A. 2011
    ....
  81. ncbi Routine HIV screening in the emergency department using the new US Centers for Disease Control and Prevention Guidelines: results from a high-prevalence area
    Jeremy Brown
    Department of Emergency Medicine, The George Washington University Medical Center, Medical Faculty Associates, 2150 Pennsylvania Avenue NW, Washington, DC 20037, USA
    J Acquir Immune Defic Syndr 46:395-401. 2007
    ..We established a screening program implementing these recommendations at an urban university hospital ED in Washington, DC. We report the results of this program...
  82. doi Screening for and early detection of chronic obstructive pulmonary disease
    Joan B Soriano
    CIMERA International Center for Advanced Respiratory Medicine, Recinte Hospital Joan March, Bunyola, Spain
    Lancet 374:721-32. 2009
    ..All in all, spirometry is recognised as the essential test for diagnosis and monitoring of COPD...
  83. ncbi Long-term prediction of prostate cancer up to 25 years before diagnosis of prostate cancer using prostate kallikreins measured at age 44 to 50 years
    Hans Lilja
    Department of Laboratory Medicine, Lund University, University Hospital UMAS, Malmo, Sweden
    J Clin Oncol 25:431-6. 2007
    ..We examined whether prostate-specific antigen (PSA) forms and human kallikrein 2 (hK2) measured at age 44 to 50 years predict long-term risk of incident prostate cancer...
  84. pmc Mortality results from the Göteborg randomised population-based prostate-cancer screening trial
    Jonas Hugosson
    Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Göteborg, Sweden
    Lancet Oncol 11:725-32. 2010
    ..One strategy to decrease the risk of death from this disease is screening with prostate-specific antigen (PSA); however, the extent of benefit and harm with such screening is under continuous debate...
  85. pmc Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study
    Joakim Dillner
    Lund University, Medical Microbiology, University Hospital MAS, 205 02 Malmo, Sweden
    BMJ 337:a1754. 2008
    ..To obtain large scale and generalisable data on the long term predictive value of cytology and human papillomavirus (HPV) testing for development of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+)...
  86. doi Inequalities in participation in an organized national colorectal cancer screening programme: results from the first 2.6 million invitations in England
    Christian von Wagner
    Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, London, Greater London, UK
    Int J Epidemiol 40:712-8. 2011
    ..Design Cross-sectional analysis of colorectal cancer screening uptake data...
  87. ncbi Screening for colorectal cancer: a targeted, updated systematic review for the U.S. Preventive Services Task Force
    Evelyn P Whitlock
    Kaiser Permanente Center for Health Research, Portland, Oregon, USA
    Ann Intern Med 149:638-58. 2008
    ....
  88. ncbi Development and evaluation of a new chest radiograph reading and recording system for epidemiological surveys of tuberculosis and lung disease
    S den Boon
    Department of Paediatrics and Child Health, Faculty of Health Sciences, Desmond Tutu TB Centre, Stellenbosch University, Cape Town, South Africa
    Int J Tuberc Lung Dis 9:1088-96. 2005
    ..The development and evaluation of a new chest radiograph reading and recording system (CRRS) for community surveys of tuberculosis (TB) and lung disease...
  89. pmc Routine HIV testing in Botswana: a population-based study on attitudes, practices, and human rights concerns
    Sheri D Weiser
    Physicians for Human Rights, Cambridge, Massachusetts, United States of America
    PLoS Med 3:e261. 2006
    ..The Botswana government recently implemented a policy of routine or "opt-out" HIV testing in response to the high prevalence of HIV infection, estimated at 37% of adults...
  90. pmc Sociodemographic gradients in breast and cervical cancer screening in Korea: the Korean National Cancer Screening Survey (KNCSS) 2005-2009
    Mi Jin Park
    National Cancer Control Institute, National Cancer Center, 111 Jungbalsan ro, Ilsandong gu, Goyang si, Gyeonggi do 410 769, Korea
    BMC Cancer 11:257. 2011
    ..1%) and the third highest was cervical cancer (76.1%). Despite overall increases in the screening rate, disparities in breast and cervical cancer screening, based on sociodemographic characteristics, still exist...
  91. pmc Examining the role of perceived susceptibility on colorectal cancer screening intention and behavior
    Amy McQueen
    Division of Health Behavior Research, Washington University, School of Medicine, Campus Box 8504, 4444 Forest Park Ave, St Louis, MO, 63108, USA
    Ann Behav Med 40:205-17. 2010
    ..The role of perceived susceptibility was not limited to direct effects but involved mediating and moderating pathways of influence...
  92. doi HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial
    Henry C Kitchener
    School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK
    Lancet Oncol 10:672-82. 2009
    ....
  93. doi Acceptability of the internet-based Chlamydia screening implementation in the Netherlands and insights into nonresponse
    Katie E Greenland
    Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Sex Transm Dis 38:467-74. 2011
    ....
  94. doi Mass screening for prostate cancer in Korea: a population based study
    Cheryn Song
    Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
    J Urol 180:1949-52; discussion 1952-3. 2008
    We investigated the detection rate of prostate cancer in Korean men through a population based mass screening test.
  95. ncbi Evaluation of the Drug Use Disorders Identification Test (DUDIT) in criminal justice and detoxification settings and in a Swedish population sample
    Anne H Berman
    Center for Health Equity Studies, Stockholm University Karolinska Institutet, Department of Psychology, Stockholm University, Stockholm, Sweden
    Eur Addict Res 11:22-31. 2005
    ..1% scored positive on the DUDIT; T-score values are suggested. The DUDIT screens effectively for drug-related problems in clinically selected groups and may prove useful in the context of public health surveys...
  96. ncbi The advanced adenoma as the primary target of screening
    Sidney J Winawer
    Department of Medicine, Memorial Sloan Kettering Cancer Center, and Weill Medical College of Cornell University, New York, New York 10021, USA
    Gastrointest Endosc Clin N Am 12:1-9, v. 2002
    ....
  97. doi Tuberculosis among foreign-born persons in the United States
    Kevin P Cain
    Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E 10, Atlanta, GA 30333, USA
    JAMA 300:405-12. 2008
    ..Foreign-born persons accounted for 57% of all tuberculosis (TB) cases in the United States in 2006. Current TB control strategies have not sufficiently addressed the high levels of TB disease and latent TB infection in this population...
  98. pmc Rationale, design, and results of the first screening round of a comprehensive, register-based, Chlamydia screening implementation programme in the Netherlands
    Jan E A M van Bergen
    STI AIDS Netherlands, Amsterdam, The Netherlands
    BMC Infect Dis 10:293. 2010
    ..Here, we describe the rationale, design, and implementation of a Chlamydia screening demonstration programme...

Research Grants87

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Also, there will be a measurement of pressure in the eye and thickness of the cornea. To study patients'DNA, the researchers will obtain a bloo..
  3. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  4. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  5. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  6. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  7. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..Ourmissionalsoincludesmonitorinbgloodsafety amongtransfusion-dependtehnatlassemipaatientsa,ndprovidingoutreachand educationservicestoallat-riskpopulationtshroughoutht estate. ..
  8. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..The Panel recommended that studies should be conducted to further characterize the in vitro test methods and that testing strategies should be designed in coordination with ICCVAM. ..
  9. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..The Panel recommended that studies should be conducted to further characterize the in vitro test methods and that testing strategies should be designed in coordination with ICCVAM. ..
  10. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..In addition to human plasma and human plasma proteins such as fibrinogen, the developed technology will also be applicable to recombinant therapeutics, monoclonal antibodies, transgenics and vaccines. ..
  11. Vaccine Development for Falciparum Malaria in Pregnant Women and Their Offspring
    Ian C Michelow; Fiscal Year: 2013
    ..Candidate vaccine proteins will be screened, confirmed and selected for clinical trials using pioneering molecular tools and blood samples from pregnant African women and their infants. ..
  12. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ....
  13. Identification of Genetic and Epigenetic Alterations in Spondyloarthritis
    Tibor T Glant; Fiscal Year: 2013
    ....
  14. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..The results may lead to new drugs and interventions to improve eating behavior, and help establish unbiased indicators of obesity risk and prognosis for use in research and clinical settings. ..
  15. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..Findings from this study will suggest mechanisms to explain the prior observed associations between sleep duration and CVD risk factors. ..
  16. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ....
  17. Infant Screening and Diagnosis of Duchenne Muscular Dys*
    Paul Fernhoff; Fiscal Year: 2007
    ..These data points will be tracked throughout the project. ..
  18. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact. ..
  19. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact. ..
  20. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..abstract_text> ..
  21. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans. ..
  22. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..abstract_text> ..
  23. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..The chemical probes designed, synthesized and validated in this proposal will have applications in the discovery of molecular targets to treat diseases such as cancer and in the development of safe stem cell based therapeutics. ..
  24. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..The results of this study will aid in the development of evidence-based guidelines for the treatment of Alaska Native infants diagnosed with CPT1A deficiency by newborn screening. ..
  25. Neurobehavioral Correlates of Familial/genetic obesity risk in adolescents
    Susan Carnell; Fiscal Year: 2013
    ..abstract_text> ..
  26. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..The results of this study may lead to new treatments to combat this severe and often fatal lung infection. ..
  27. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    ..Additionally, insight will be gained into the regulation of T cell function in both health and disease with relevance to an array of immune and neoplastic diseases. ..
  28. Behavioral Activation Therapy for Rural Veterans with Diabetes and Depression
    Aanand Dinkar Naik; Fiscal Year: 2013
    ..As therapists are all advanced psychology graduate students, it is unclear whether individuals without such previous training can implement the intervention. This may hamper implementation efforts. ..
  29. Functional Genomics of the Mitochondrial Proteome
    Dennis R Winge; Fiscal Year: 2011
    ..The function of up to 30% of the mitochondrial proteome is unknown. This proposal will elucidate the function of these un-annotated mitochondrial proteins, providing new insights into the role of mitochondria in human disease. ..
  30. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2009
    ..NICEATM and ICCVAM will also evaluate non-animal methods and approaches for determining the skin irritation potential of antimicrobial cleaning products...
  31. Hepcidin-based screening for infantile iron deficiency
    Mark D Fleming; Fiscal Year: 2010
    ....
  32. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..The proposed experiments will provide essential mechanistic insight into the previously observed radio-protective and -mitigative effects of CBLB502. ..
  33. Improving TB Diagnosis in Children with and without HIV in Kenya
    Rinn Song; Fiscal Year: 2013
    ....
  34. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..However, larger well designed clinical studies are needed to corroborate initial results. ..
  35. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..Functional characterization of such a pathway has implications for identifying early markers of disease progression in human myeloid malignancy and rational targets for molecular therapeutic approaches to diseases such as CML and MDS. ..
  36. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..The proposed systems to screen a library of compounds to rescue TS phenotypes will provide a platform to find novel lead compounds that would be clinically useful for the treatment of not only TS but also other cardiac arrhythmias. ..
  37. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..abstract_text> ..
  38. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    ....
  39. Phage Display for Improved Peptide-based Tumor Targeting and Imaging Agents
    Susan L Deutscher; Fiscal Year: 2013
    ..This work is significant and relevant to the VA mission because the peptides discovered here may translate into novel prostate, breast, and ovarian cancer diagnostics and therapeutics for our veterans. ..
  40. Regulation of Cell Signaling by Human Biliverdin Reductase
    Mahin D Maines; Fiscal Year: 2013
    ..In addition, the enzyme activity is necessary for protection against the fatal "green jaundice". Our work has revealed a novel approach for development of therapeutic interventions in a range of human diseases. ..
  41. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..An understanding of this pathway should ultimately enable better management of diabetic veterans and conceivably lead to the design a single therapy, which can simultaneously target both osteoporosis and type 2 diabetes. ..
  42. Identification and Analysis of Flavivirus Protease and RNA Helicase Inhibitors
    Radhakrishnan Padmanabhan; Fiscal Year: 2009
    ....
  43. Viral and Host Determinants of New World Alphaviral Entry
    ASIM AMINSHARIF AHMED; Fiscal Year: 2013
    ..Children's Hospital Boston is committed to this career development plan and has assured the candidate will be able to devote at least 85% full-time effort to the activities described in this proposal. ..
  44. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..The long-term objectives of this research are to elucidate the molecular mechanism of regulation of CYP7A1 and bile acid metabolism, and pathogenesis and treatment of metabolic diseases such as fatty liver disease, diabetes and obesity. ..
  45. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    ..We will test the new machine on mouse oocytes, mouse and rat embryos, and zebrafish embryos. ..
  46. Tissue-specific delivery of probes by control of membrane trafficking of endoprot
    Blake Peterson; Fiscal Year: 2010
    ....
  47. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ....
  48. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..This project will identify potential therapeutic targets and molecules that will provide the basis for future therapies of these chronic lung diseases that, together, comprise a major health problem world-wide. ..
  49. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..My project proposes to better understand the role of iron mobilization from lysosomes to mitochondria in ischemia/reperfusion injury and to develop novel therapies to mitigate or eliminate damage from this condition. ..
  50. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..In this project we intend to develop a new drug (and back-up) for effective treatment of ~100,000 cases of systemic amyloidosis in the USA, for which today there is no real treatment whatsoever. ..
  51. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..Therefore, our study will help delivering a novel pharmaceutical target, and suitable lead compounds for the treatment of lung inflammation, such as ALI and ARDS. ..
  52. C5a as an Anti-HIV Microbicidal Candidate
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..In addition, protective results would provide proof-of-concept of the usefulness of topically applied microbicides, such as C5A, to prevent genital HIV transmission. ..
  53. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ....
  54. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ....
  55. Molecular Mechanisms of Disease Progression in Myeloid Malignancy
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..Targeting these mechanisms may lead to cure in CML by abolishing the CSC/LSC, and suggest therapeutic approaches to other forms of cancer with dysregulation of Fas and bcatenin. ..
  56. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..These results are expected to reveal deeper insight into interactive roles of inflammatory mediators in marrow regeneration and have relevance for combinatorial targeting to direct clinical outcome in transfusion biology. ..
  57. Novel Reagents and Methods for Rapid and High Throughput Detection of Aflatoxin C
    ALAN AI PING WEI; Fiscal Year: 2013
    ..Our research aims to bridge this gap by developing rapid, high throughput and automated technologies for aflatoxin detection. ..
  58. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..This proposal will help to train a pool of talented young scientists to pursue mouse model research and accelerate development of therapies for inflammatory diseases. ..
  59. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Interleukin-17 can cause lung inflammation and asthma. This project is to indentify drugs that can inhibit IL-17 and lung inflammation. ..
  60. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..Patients with learning disorders and those suffering from complications due to neurodegenerative diseases will greatly benefit as PWZ-029 moves another step closer to the clinic. ..
  61. Regulation of NFkappaB activity by the Estrogen Receptor
    Kendall W Nettles; Fiscal Year: 2012
    ..We propose to use these synthetic compounds to understand the molecular details of this important anti-inflammatory pathway. ..
  62. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ....
  63. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..The goal of this project is to use chemical screening to identify novel drugs to treat one type of CMT and test them in mouse models of the disease. ..
  64. Combined raman spectroscopy-optical tomagraphy for complete diagnosis of skin can
    Anita Mahadevan Jansen; Fiscal Year: 2009
    ..With the success of this technique, RSOCT can be applied to other organ sites such as the breast, prostate and ovary as well as other diseases thus impacting a broader field in medicine. ..
  65. Development and Validation of a Panel of Breast Cancer for the Early Diagnosis of
    FELIX RODOLFO FERNANDEZ MADRID; Fiscal Year: 2010
    ..We propose that this test used in conjunction with mammography has the potential to complement and increase the accuracy of the screening process. ..
  66. Novel Informatics for Highly Reliable Multi-Locus Allele Calling for Embryo Scree
    Matthew Rabinowitz; Fiscal Year: 2009
    ..GSN's PS technology of will bring the domain of PGD into the realm of reliable diagnostics which can be regulated and used as part of the standard of care during in-vitro fertilization. ..
  67. Determinants of Participation in an Anal Cancer Prevention Trial
    Joel Palefsky; Fiscal Year: 2010
    ....
  68. Easy-to-Use, Low-Cost, Handheld Retinal Camera for Screening for Diabetic Retinop
    RANDAL CHINNOCK; Fiscal Year: 2009
    ....
  69. A Microfluidic Biochip for Rapid Screening of Pesticide Residue
    Xiaoli Su; Fiscal Year: 2010
    ....
  70. National Lung Study Trial
    Douglas Reding; Fiscal Year: 2009
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact. ..
  71. National Lung Screening Trial (NLST)
    Cheryl Robinson; Fiscal Year: 2009
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact. ..
  72. Colorectal Cancer Screening in Southwestern Hispanics and Native Americans
    Robert Rhyne; Fiscal Year: 2009
    ..abstract_text> ..
  73. High throughput screening assays to identify small molecules that target the ClpX
    Carolyn K Suzuki; Fiscal Year: 2010
    ..In addition, activators of ClpXP and/or Lon may also be exploited in the treatment of neurodegenerative disorders linked to mitochondrial protein aggregation. ..
  74. Pilot study of Newborn screening for hemoglobinopathies in South Gujarat India
    Lakshmanan Krishnamurti; Fiscal Year: 2009
    ....
  75. Screening for Jervell and Lange-Nielsen Syndrome
    Ruey Kang R Chang; Fiscal Year: 2010
    ..While mass screening of the general population for JLNS is not practical, the prevalence of JLNS in older children with congenital ..
  76. Spatial, Temporal, Social Disparities in Breast Cancer
    Mario Schootman; Fiscal Year: 2010
    ....
  77. Development of Behavioral and Social Interventions that Reduce Stigma and Improve
    Crystal M Fuller; Fiscal Year: 2010
    ....
  78. Regional Cystic fibrosis DNA Mutation Analysis
    JANE P GETCHELL; Fiscal Year: 2010
    ..1 ..
  79. High Content Screening for Muscular Dystrophy
    Herman Vandenburgh; Fiscal Year: 2007
    ..While not a cure for the disease, these new drug therapies are aimed at enhancing quality and longevity of life of the DMD patient. [unreadable] [unreadable] [unreadable] [unreadable]..
  80. Development of a disposable shippable chip for high throughput ion channel screen
    JASON POULOS; Fiscal Year: 2009
    ..We propose here to develop inexpensive membrane array chips and use them for large scale production, demonstrating the feasibility of this technology for ion channel screening. ..
  81. Cost-effectiveness of genetic screening for colon cancer
    Sandeep Vijan; Fiscal Year: 2006
    ..Outcome measures: The risks of developing or dying from CRC, the costs of screening, and the incremental cost-effectiveness of various screening regimens. ..
  82. Quantifying Risk to Target Screening Colonoscopy
    Thomas Imperiale; Fiscal Year: 2009
    ..The knowledge generated by this research will help maximize prevention and minimize the morbidity and cost of CRC screening. ..
  83. Past Experiences and Current Mammography Behaviors
    Eileen Thomas; Fiscal Year: 2005
    ..abstract_text> ..
  84. Role of Physicians and Their Groups in Cancer Screening
    George Wright; Fiscal Year: 2005
    ..Since the proposed methodology is new, a small grant is proposed to develop and validate the approach and to generate initial substantive results. ..