false positive reactions

Summary

Summary: Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)

Top Publications

  1. ncbi Assessing the probability that a positive report is false: an approach for molecular epidemiology studies
    Sholom Wacholder
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 96:434-42. 2004
  2. pmc Assessment of the prozone effect in malaria rapid diagnostic tests
    Philippe Gillet
    Department of Clinical Sciences, Institute of Tropical Medicine ITM, Nationalestraat 155, B 2000 Antwerp, Belgium
    Malar J 8:271. 2009
  3. pmc Test characteristics of two rapid antigen detection tests (SD FK50 and SD FK60) for the diagnosis of malaria in returned travellers
    Mirna Van der Palen
    Faculty of Health, Medicine and Life Sciences FHML, Maastricht, The Netherlands
    Malar J 8:90. 2009
  4. ncbi Automated detection of pulmonary nodules in helical CT images based on an improved template-matching technique
    Y Lee
    Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, Niigata University, Japan
    IEEE Trans Med Imaging 20:595-604. 2001
  5. ncbi Digital breast tomosynthesis: observer performance study
    David Gur
    Radiology Imaging Research, Department of Radiology, University of Pittsburgh, 3362 Fifth Ave, Rm 223 FARP Bldg, Pittsburgh, PA 15213, USA
    AJR Am J Roentgenol 193:586-91. 2009
  6. ncbi Histological examination of false positive tissue resection using 5-aminolevulinic acid-induced fluorescence guidance
    Satoshi Utsuki
    Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan
    Neurol Med Chir (Tokyo) 47:210-3; discussion 213-4. 2007
  7. pmc Plasmodium falciparum histidine-rich protein 2-based immunocapture diagnostic assay for malaria: cross-reactivity with rheumatoid factors
    J Iqbal
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait
    J Clin Microbiol 38:1184-6. 2000
  8. ncbi Prospective evaluation of a rapid diagnostic test Typhidot for typhoid fever
    Mary V Jesudason
    Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India
    Indian J Med Res 123:513-6. 2006
  9. ncbi Systematic review: the long-term effects of false-positive mammograms
    Noel T Brewer
    Department of Health Behavior and Health Education, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Ann Intern Med 146:502-10. 2007
  10. pmc Influence of computer-aided detection on performance of screening mammography
    Joshua J Fenton
    University of California, Davis, Sacramento, USA
    N Engl J Med 356:1399-409. 2007

Detail Information

Publications299 found, 100 shown here

  1. ncbi Assessing the probability that a positive report is false: an approach for molecular epidemiology studies
    Sholom Wacholder
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 96:434-42. 2004
    ..An FPRP-based criterion for deciding whether to call a finding noteworthy formalizes the process already used informally by investigators--that is, tempering enthusiasm for remarkable study findings with considerations of plausibility...
  2. pmc Assessment of the prozone effect in malaria rapid diagnostic tests
    Philippe Gillet
    Department of Clinical Sciences, Institute of Tropical Medicine ITM, Nationalestraat 155, B 2000 Antwerp, Belgium
    Malar J 8:271. 2009
    ..In this study, a panel of malaria RDTs was challenged with clinical samples with P. falciparum hyperparasitaemia (> 5% infected red blood cells)...
  3. pmc Test characteristics of two rapid antigen detection tests (SD FK50 and SD FK60) for the diagnosis of malaria in returned travellers
    Mirna Van der Palen
    Faculty of Health, Medicine and Life Sciences FHML, Maastricht, The Netherlands
    Malar J 8:90. 2009
    ..Two malaria rapid diagnostic tests were evaluated in a travel clinic setting: the SD FK50 Malaria Ag Plasmodium falciparum test (a two-band test) and the SD FK60 Malaria Ag P. falciparum/Pan test (a three-band test)...
  4. ncbi Automated detection of pulmonary nodules in helical CT images based on an improved template-matching technique
    Y Lee
    Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, Niigata University, Japan
    IEEE Trans Med Imaging 20:595-604. 2001
    ..1/sectional image. Our present results show that our scheme can be regarded as a technique for CAD systems to detect nodules in helical CT pulmonary images...
  5. ncbi Digital breast tomosynthesis: observer performance study
    David Gur
    Radiology Imaging Research, Department of Radiology, University of Pittsburgh, 3362 Fifth Ave, Rm 223 FARP Bldg, Pittsburgh, PA 15213, USA
    AJR Am J Roentgenol 193:586-91. 2009
    ..The purpose of this study was to compare in a retrospective observer study the diagnostic performance of full-field digital mammography (FFDM) with that of digital breast tomosynthesis...
  6. ncbi Histological examination of false positive tissue resection using 5-aminolevulinic acid-induced fluorescence guidance
    Satoshi Utsuki
    Department of Neurosurgery, Kitasato University School of Medicine, Kanagawa, Japan
    Neurol Med Chir (Tokyo) 47:210-3; discussion 213-4. 2007
    ..In contrast, all weak positive areas of recurrent malignant gliomas must be resected. Weak positive areas of the peritumoral edema surrounding metastatic brain tumors should be removed carefully as false positive results are common...
  7. pmc Plasmodium falciparum histidine-rich protein 2-based immunocapture diagnostic assay for malaria: cross-reactivity with rheumatoid factors
    J Iqbal
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait
    J Clin Microbiol 38:1184-6. 2000
    ..Our study shows that the PfHRP-2-based ICT assay gave a false-positive reaction in 26% of the patients who had rheumatoid factors, but were negative for malaria by microscopy...
  8. ncbi Prospective evaluation of a rapid diagnostic test Typhidot for typhoid fever
    Mary V Jesudason
    Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India
    Indian J Med Res 123:513-6. 2006
    ..A simple, reliable and affordable rapid diagnostic test has been a long felt need of the clinicians. We therefore prospectively evaluated the sensitivity and specificity of Typhidot test...
  9. ncbi Systematic review: the long-term effects of false-positive mammograms
    Noel T Brewer
    Department of Health Behavior and Health Education, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Ann Intern Med 146:502-10. 2007
    ..Although abnormal screening mammograms deleteriously affect the psychological well-being of women during the time immediately surrounding the tests, their long-term effects are poorly understood...
  10. pmc Influence of computer-aided detection on performance of screening mammography
    Joshua J Fenton
    University of California, Davis, Sacramento, USA
    N Engl J Med 356:1399-409. 2007
    ..Since the Food and Drug Administration approved the technology in 1998, it has been disseminated into practice, but its effect on the accuracy of interpretation is unclear...
  11. pmc Genomic dissection of population substructure of Han Chinese and its implication in association studies
    Shuhua Xu
    Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    Am J Hum Genet 85:762-74. 2009
    ..These signals indicating significant differences among Han Chinese subpopulations should be carefully explained in case they are also detected in association studies, especially when sample sources are diverse...
  12. pmc Malaria rapid diagnostic tests: Plasmodium falciparum infections with high parasite densities may generate false positive Plasmodium vivax pLDH lines
    Jessica Maltha
    Faculty of Health, Medicine and Life Sciences FHML, Maastricht, The Netherlands
    Malar J 9:198. 2010
    ..Previous observations of false positive Pv-pLDH test lines in P. falciparum samples incited to the present study, which assessed P. vivax-specific RDTs for the occurrence of false positive Pv-pLDH lines in P. falciparum samples...
  13. pmc HIV incidence in rural South Africa: comparison of estimates from longitudinal surveillance and cross-sectional cBED assay testing
    Till Barnighausen
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Durban, South Africa
    PLoS ONE 3:e3640. 2008
    ....
  14. ncbi Fully automatic segmentation of multiple sclerosis lesions in brain MR FLAIR images using adaptive mixtures method and Markov random field model
    Rasoul Khayati
    Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran
    Comput Biol Med 38:379-90. 2008
    ..The results showed a better performance for the proposed approach, compared to those of previous works...
  15. ncbi Comparative assessment of large-scale data sets of protein-protein interactions
    Christian von Mering
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Nature 417:399-403. 2002
    ..To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions...
  16. ncbi Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    Kirk E Lohmueller
    Whitehead Massachuetts Institute of Technology Center for Genome Research, Cambridge, Massachusetts 02139, USA
    Nat Genet 33:177-82. 2003
    ..We conclude that there are probably many common variants in the human genome with modest but real effects on common disease risk, and that studies using large samples will convincingly identify such variants...
  17. ncbi fdrtool: a versatile R package for estimating local and tail area-based false discovery rates
    Korbinian Strimmer
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Hartelstr 16 18, 04107 Leipzig, Germany
    Bioinformatics 24:1461-2. 2008
    ..Consequently, 'fdrtool' implements a flexible FDR estimation scheme that is unified across different test statistics and variants of FDR...
  18. ncbi Open mass spectrometry search algorithm
    Lewis Y Geer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    J Proteome Res 3:958-64. 2004
    ..At default thresholds, OMSSA matches more spectra from a standard protein cocktail than a comparable algorithm. OMSSA is designed to be faster than published algorithms in searching large MS/MS datasets...
  19. ncbi Mycobacterium fortuitum infection interference with Mycobacterium bovis diagnostics: natural infection cases and a pilot experimental infection
    Anita L Michel
    Tuberculosis Laboratory, Bacteriology Section, Agricultural Research Council Onderstepoort Veterinary Institute, Onderstepoort, South Africa
    J Vet Diagn Invest 20:501-3. 2008
    ..The implications of occasional cross-reactive responses in natural cases of infection with environmental mycobacteria in the diagnosis of bovine tuberculosis in African buffalo and cattle in South Africa are discussed...
  20. ncbi An estimate of overdiagnosis 15 years after the start of mammographic screening in Florence
    Donella Puliti
    Clinical and Descriptive Epidemiology Unit, ISPO Cancer Prevention and Research Institute, via San Salvi 12, 50135 Florence, Italy
    Eur J Cancer 45:3166-71. 2009
    ..The aim of this study is to evaluate the degree of overdiagnosis of breast cancer 15 years after the introduction of service screening in Florence (Italy)...
  21. ncbi Cataract and glaucoma case detection for Vision 2020 programs in Africa: an evaluation of 6 possible screening tests
    Colin Cook
    Department of Ophthalmology, Groote Schuur Hospital, Observatory, Cape Town, South Africa
    J Glaucoma 18:557-62. 2009
    ..To determine if there is a screening test or a combination of screening tests that may be suitable for cataract and glaucoma case detection in Vision 2020 programs in Africa...
  22. pmc Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks
    David A Nix
    Huntsman Cancer Institute, Department of Research Informatics, University of Utah, Salt Lake City, Utah, 84105, USA
    BMC Bioinformatics 9:523. 2008
    ....
  23. pmc Overdiagnosis in organised mammography screening in Denmark. A comparative study
    Karsten J Jørgensen
    The Nordic Cochrane Centre, Rigshospitalet, Dept 3343, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    BMC Womens Health 9:36. 2009
    ..We quantified overdiagnosis in the Danish mammography screening programme, which is uniquely suited for this purpose, as only 20% of the Danish population has been offered organised mammography screening over a long time-period...
  24. ncbi Eigendetection of masses considering false positive reduction and breast density information
    Jordi Freixenet
    Institute of Informatics and Applications IdiBGi, University of Girona, Campus Montilivi, Ed P IV 17071, Girona, Spain
    Med Phys 35:1840-53. 2008
    ....
  25. pmc False-positive rifampicin resistance on Xpert® MTB/RIF: case report and clinical implications
    A van Rie
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Int J Tuberc Lung Dis 16:206-8. 2012
    ..When decentralising Xpert, test performance characteristics need to be understood by health care workers and methods of confirmation of RMP resistance need to be accessible...
  26. ncbi A system to detect the onset of epileptic seizures in scalp EEG
    M E Saab
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Que, Canada H3A 2B4
    Clin Neurophysiol 116:427-42. 2005
    ..The system is based on determining the seizure probability of a section of EEG. Operation features a user-tuneable threshold to exploit the trade-off between sensitivity and detection delay and an acceptable false detection rate...
  27. ncbi Risk of breast cancer after false-positive test results in screening mammography
    My von Euler-Chelpin
    Department of Public Health, University of Copenhagen, Copenhagen K, Denmark
    J Natl Cancer Inst 104:682-9. 2012
    ..Normally, women with false-positive screening tests for breast cancer are referred back to routine screening. However, the long-term outcome for women with false-positive tests is unknown...
  28. pmc Computer-aided diagnosis of pulmonary nodules on CT scans: segmentation and classification using 3D active contours
    Ted W Way
    Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Med Phys 33:2323-37. 2006
    ..The lung nodule volumes segmented by the 3D AC model for best classification were generally larger than those outlined by the LIDC radiologists using visual judgment of nodule boundaries...
  29. pmc False-positive Plasmodium falciparum histidine-rich protein 2 immunocapture assay results for acute schistosomiasis caused by Schistosoma mekongi
    Eyal Leshem
    Center for Geographic Medicine and Tropical Diseases, Tel Hashomer, Israel
    J Clin Microbiol 49:2331-2. 2011
    ..PfHRP2 assays were negative in travelers infected with Schistosoma mansoni or Schistosoma haematobium (n = 13). Malaria was ruled out and rheumatoid factor was negative in all patients...
  30. pmc Effect of protocol-related variables and women's characteristics on the cumulative false-positive risk in breast cancer screening
    R Roman
    Department of Epidemiology and Evaluation, Institut Municipal d Investigació Mèdica Parc de Salut Mar Barcelona, Barcelona, Spain
    Ann Oncol 23:104-11. 2012
    ..Reducing the false-positive risk in breast cancer screening is important. We examined how the screening-protocol and women's characteristics affect the cumulative false-positive risk...
  31. pmc Factors affecting reproducibility between genome-scale siRNA-based screens
    Nicholas J Barrows
    Department of Molecular Genetics and Microbiology, Duke NUS Graduate Medical School, Durham, NC, USA
    J Biomol Screen 15:735-47. 2010
    ....
  32. ncbi Psychological consequences of false-positive screening mammograms in the UK
    Mary Bond
    PenTAG, University of Exeter, Peninsula Medical School, Exeter, Devon, UK
    Evid Based Med 18:54-61. 2013
    ..To identify the psychological effects of false-positive screening mammograms in the UK...
  33. pmc Indoor collections of the Anopheles funestus group (Diptera: Culicidae) in sprayed houses in northern KwaZulu-Natal, South Africa
    Joel C Mouatcho
    Vector Control Reference Unit, National Institute for Communicable Diseases, NHLS, Private Bag X4, Sandringham, Johannesburg 2131, South Africa
    Malar J 6:30. 2007
    ..Subsequent monitoring and surveillance of mosquito populations were conducted as part of the malaria vector control programme...
  34. ncbi Web-based grading of compressed stereoscopic digital photography versus standard slide film photography for the diagnosis of diabetic retinopathy
    Christopher J Rudnisky
    Department of Ophthalmology, University of Alberta, Edmonton, Canada
    Ophthalmology 114:1748-54. 2007
    ....
  35. ncbi Effects of false-positive results in a breast screening program on anxiety, depression and health-related quality of life
    Bjorg Hafslund
    Institute of Radiography, Faculty of Health and Social Sciences, Bergen University College, Norway
    Cancer Nurs 35:E26-34. 2012
    ..No long-term effects have been fully demonstrated, and the findings for anxiety and depression are contradictory. Few studies have addressed changes in health-related quality of life (HRQOL)...
  36. ncbi Expanded newborn screening for biochemical disorders: the effect of a false-positive result
    Elizabeth A Gurian
    Department of Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Pediatrics 117:1915-21. 2006
    ..False-positive identifications may increase as disorders are added to screening panels. Concerns arise regarding the potential impact on parental stress, family relationships, and perceptions of the child's health...
  37. pmc Anniversary paper: History and status of CAD and quantitative image analysis: the role of Medical Physics and AAPM
    Maryellen L Giger
    Department of Radiology, University of Chicago, Chicago, Illinois 60637, USA
    Med Phys 35:5799-820. 2008
    ..A historical review of CAD and a discussion of challenges for the future are presented here, along with the extension to quantitative image analysis...
  38. ncbi False-positive and false-negative cases of fine-needle aspiration cytology for palpable breast lesions
    Takashi Ishikawa
    Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, Yokohama, 232 0024, Japan
    Breast Cancer 14:388-92. 2007
    ..Fine-needle aspiration cytology (FNA) is less traumatic and technically easy to apply to small breast tumors...
  39. ncbi Comparison of radiologist and CAD performance in the detection of CT-confirmed subtle pulmonary nodules on digital chest radiographs
    Thorsten Alexander Bley
    Department of Diagnostic Radiology, University Hospital Freiburg, Freiburg, Germany
    Invest Radiol 43:343-8. 2008
    ..Detection of subtle pulmonary nodules on digital radiography is a challenging task for radiologists. The aim of this study was to evaluate the performance of a newly approved computer aided detection (CAD) system...
  40. ncbi Parental tolerance of false-positive newborn screening results
    Lisa A Prosser
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, Sixth Floor, Boston, MA 02215, USA
    Arch Pediatr Adolesc Med 162:870-6. 2008
    ..To measure parental tolerance for a false-positive newborn screening result by assessing perceived quality of life for screening results and health states associated with expanded newborn screening programs for metabolic disorders...
  41. pmc Overdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trends
    Karsten Juhl Jørgensen
    The Nordic Cochrane Centre, Rigshospitalet, Dept 3343, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    BMJ 339:b2587. 2009
    ..To estimate the extent of overdiagnosis (the detection of cancers that will not cause death or symptoms) in publicly organised screening programmes...
  42. ncbi Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay
    Marcus Ang
    Singapore National Eye Centre, Singapore
    Ophthalmology 116:1391-6. 2009
    ..To determine the role of the QuantiFERON-TB Gold In-Tube (QFT) (Cellestis Inc., Carnegie, Australia) assay in the diagnosis of tuberculosis (TB) uveitis...
  43. ncbi Automated neonatal seizure detection mimicking a human observer reading EEG
    W Deburchgraeve
    Department of Electrical Engineering ESAT, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, 3001 Leuven Heverlee, Belgium
    Clin Neurophysiol 119:2447-54. 2008
    ..The description and evaluation of a novel patient-independent seizure detection for the EEG of the newborn term infant...
  44. ncbi Seizure detection algorithm for neonates based on wave-sequence analysis
    Michael A Navakatikyan
    BrainZ Instruments Ltd, 25 Carbine Road, Mt Wellington, P O Box 51078 Pakuranga, Auckland 1730, New Zealand
    Clin Neurophysiol 117:1190-203. 2006
    ..The description and evaluation of the performance of a new real-time seizure detection algorithm in the newborn infant...
  45. ncbi Lung nodule detection on thoracic computed tomography images: preliminary evaluation of a computer-aided diagnosis system
    Metin N Gurcan
    Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 0904, USA
    Med Phys 29:2552-8. 2002
    ..These preliminary results demonstrate the feasibility of our approach to lung nodule detection and FP reduction on CT images...
  46. ncbi The cumulative risk of a false-positive recall in the Norwegian Breast Cancer Screening Program
    Solveig Hofvind
    The Cancer Registry of Norway, Montebello, Oslo
    Cancer 101:1501-7. 2004
    ..A secondary objective was to estimate the cumulative risk of undergoing fine-needle aspiration cytology, core needle biopsy, and open biopsy with benign morphology in the same group of women...
  47. ncbi Mammography in 53,803 women from the New Hampshire mammography network
    S P Poplack
    Departments of Radiology, Dartmouth Hitchcock Medical Center, 1 Medical Center Dr, HB 7999, Lebanon, NH 03756, USA
    Radiology 217:832-40. 2000
    ..To describe measures of mammography performance in a geographically defined population and evaluate the interpreter's use of the Breast Imaging Reporting and Data System (BI-RADS)...
  48. ncbi Performance evaluation of three automated human immunodeficiency virus antigen-antibody combination immunoassays
    Jung Ah Kwon
    Department of Laboratory Medicine, College of Medicine, Korea University, Seoul, Republic of Korea
    J Virol Methods 133:20-6. 2006
    ..0% to 99.6%. The Architect HIV Ag/Ab Combo exhibited the best performance for specificity and detection of p24 antigen leading to closure of seroconversion window and demonstrating its utility for early diagnosis of HIV infection...
  49. pmc False positive and false negative FDG-PET scans in various thoracic diseases
    Jung Min Chang
    Department of Radiology, Seoul National University Hospital, Seoul, Korea
    Korean J Radiol 7:57-69. 2006
    ..In this review, we illustrate false positive and negative findings of PET scan in a variety of diseases...
  50. pmc Regional differences in Finland in the prevalence of rheumatoid factor in the presence and absence of arthritis
    T Korpilähde
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Ann Rheum Dis 62:353-5. 2003
    ..To look for possible regional differences in the prevalence of rheumatoid factor (RF) in the presence and absence of arthritis...
  51. ncbi Effective prediction of preeclampsia by a combined ratio of angiogenesis-related factors
    Ji Hyae Lim
    Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women s Healthcare Center, Seoul, Korea
    Obstet Gynecol 111:1403-9. 2008
    ....
  52. ncbi Endoscopic detection of transitional cell carcinoma with 5-aminolevulinic acid: results of 1012 fluorescence endoscopies
    D Zaak
    Department of Urology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany
    Urology 57:690-4. 2001
    ..7% of these additionally detected neoplastic foci had poorly differentiated histologic features. CONCLUSIONS: AFE has proved to be a clinically feasible procedure with an outstanding detection rate for flat, urothelial, high-risk lesions...
  53. ncbi Role of conventional angiography in evaluation of patients with carotid artery stenosis demonstrated by Doppler ultrasound in general practice
    A I Qureshi
    Department of Neurosurgery and Toshiba Stroke Research Center, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, USA
    Stroke 32:2287-91. 2001
    ..We performed a 12-month prospective study to evaluate the accuracy of Doppler ultrasound in identifying patients for carotid intervention in general practice settings...
  54. pmc PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls
    Joel Rozowsky
    Molecular Biophysics and Biochemistry Dept, Yale University, PO Box 208114, New Haven, Connecticut 06520 8114, USA
    Nat Biotechnol 27:66-75. 2009
    ..Our scoring procedure enables us to optimize experimental design by estimating the depth of sequencing required for a desired level of coverage and demonstrating that more than two replicates provides only a marginal gain in information...
  55. pmc False-positive results in cancer epidemiology: a plea for epistemological modesty
    Paolo Boffetta
    Lifestyle, Environment and Cancer Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
    J Natl Cancer Inst 100:988-95. 2008
    ....
  56. pmc International variation in screening mammography interpretations in community-based programs
    Joann G Elmore
    Department of Medicine, University of Washington, Seattle, USA
    J Natl Cancer Inst 95:1384-93. 2003
    ..To evaluate international variability in mammography interpretation, we analyzed published reports from community-based screening programs from around the world...
  57. ncbi A random variance model for detection of differential gene expression in small microarray experiments
    George W Wright
    National Cancer Institute Biometric Research Branch, National Institutes of Health, 6130 Executive Blvd, MSC 7434, Bethesda, MD 20892 7434, USA
    Bioinformatics 19:2448-55. 2003
    ..This makes accurate estimation of variability difficult, since variance estimates made on a gene by gene basis will have few degrees of freedom, and the assumption that all genes share equal variance is unlikely to be true...
  58. ncbi "False-positive" cardiac catheterization laboratory activation among patients with suspected ST-segment elevation myocardial infarction
    David M Larson
    Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota 55407, USA
    JAMA 298:2754-60. 2007
    ..There are limited data on the frequency of "false-positive" catheterization laboratory activation in patients undergoing percutaneous coronary intervention for suspected STEMI...
  59. ncbi Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome
    Junmin Peng
    Department of Cell Biology, and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Proteome Res 2:43-50. 2003
    ..New criteria are proposed to decrease false-positives to less than 1% and to greatly reduce the need for manual interpretation while permitting more proteins to be identified...
  60. ncbi Total tau protein in cerebrospinal fluid and diffusion-weighted MRI as an early diagnostic marker for Creutzfeldt-Jakob disease
    Katsuya Satoh
    First Department of Internal Medicine, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan
    Dement Geriatr Cogn Disord 24:207-12. 2007
    ..Diffusion-weighted magnetic resonance imaging (DWI) and the detection of total tau (t-tau) protein in CSF may be more sensitive diagnostic criteria...
  61. ncbi Identifying combinations of cancer markers for further study as triggers of early intervention
    S G Baker
    Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, EPN 344, 6130 Executive Blvd MSC 7354, Bethesda, Maryland 20892 7354, USA
    Biometrics 56:1082-7. 2000
    ..In a separate validation sample, the ROC curve for last total PSA intersected the target region in 77% of bootstrap replications, indicating some promise for further study. We also discussed sample size calculations...
  62. pmc Investigation of false positive results with an oral fluid rapid HIV-1/2 antibody test
    Krishna Jafa
    Division of HIV AIDS Prevention, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 2:e185. 2007
    ..From August 2004-June 2005, we investigated a sudden increase in false-positive results occurring in a performance study of OraQuick oral-fluid rapid HIV tests in Minnesota...
  63. pmc Effects of mammography screening under different screening schedules: model estimates of potential benefits and harms
    Jeanne S Mandelblatt
    Georgetown University Medical Center and Lombardi Comprehensive Cancer Center, Washington, DC, USA
    Ann Intern Med 151:738-47. 2009
    ..Despite trials of mammography and widespread use, optimal screening policy is controversial...
  64. pmc Paracheck-Pf accuracy and recently treated Plasmodium falciparum infections: is there a risk of over-diagnosis?
    Todd D Swarthout
    Medecins Sans Frontieres, London, UK
    Malar J 6:58. 2007
    ..An assessment of the accuracy of Paracheck Pf, a malaria rapid diagnostic test (RDT) detecting histidine rich protein 2 was undertaken amongst children aged 6-59 months in eastern Democratic Republic of Congo...
  65. pmc A Bayesian measure of the probability of false discovery in genetic epidemiology studies
    Jon Wakefield
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 81:208-27. 2007
    ..Finally, we use BFDP to assess the association between 131 single-nucleotide polymorphisms and lung cancer in a case-control study...
  66. pmc Using computer-aided detection in mammography as a decision support
    Maurice Samulski
    Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6500 HB, Nijmegen, The Netherlands
    Eur Radiol 20:2323-30. 2010
    ..To evaluate an interactive computer-aided detection (CAD) system for reading mammograms to improve decision making...
  67. pmc Association of schistosomiasis with false-positive HIV test results in an African adolescent population
    Dean B Everett
    London School of Hygiene and Tropical Medicine, London, UK
    J Clin Microbiol 48:1570-7. 2010
    ..In Africa, endemic infections may affect the specificities of immunoassays for HIV infection. Caution should be used when the results of 4th-generation HIV test results are interpreted for African adolescent populations...
  68. pmc Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda
    S C Kagulire
    Rakai Health Sciences Program, Kalisizo, Uganda
    Int J STD AIDS 22:308-9. 2011
    ..Properly trained staff, good quality control programmes and validation of RDTs with laboratories having confirmatory testing capacity may be warranted to assure accuracy in each setting...
  69. ncbi False-positive tuberculin skin tests: what is the absolute effect of BCG and non-tuberculous mycobacteria?
    M Farhat
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University, Montreal, Quebec, Canada
    Int J Tuberc Lung Dis 10:1192-204. 2006
    ..However, TST specificity is reduced by bacille Calmette-Guérin (BCG) vaccination and exposure to non-tuberculous mycobacteria (NTM)...
  70. ncbi Lung cancers missed on chest radiographs: results obtained with a commercial computer-aided detection program
    Feng Li
    Kurt Rossmann Laboratories for Radiologic Image Research, Department of Radiology, MC 2026, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Radiology 246:273-80. 2008
    ....
  71. ncbi Interpretation of the tuberculin skin test in Mycobacterium bovis BCG-vaccinated Singaporean schoolchildren
    C B Chee
    Tuberculosis Control Unit, Department of Respiratory Medicine, and Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore
    Am J Respir Crit Care Med 164:958-61. 2001
    ..We have extrapolated these findings to the screening of contacts, and utilized these cutoff points to guide the treatment of latent TB infection in this high-risk group...
  72. ncbi Detection of genetically modified organisms in foods
    Farid E Ahmed
    Dept of Radiation Oncology, Leo W Jenkins Cancer Center, The Brody School of Medicine, LSB 014, East Carolina University, Greenville, NC 27858, USA
    Trends Biotechnol 20:215-23. 2002
    ....
  73. ncbi Comparison of two LED fluorescence microscopy build-on modules for acid-fast smear microscopy
    D Affolabi
    Laboratoire de Référence des Mycobactéries, Cotonou, Benin
    Int J Tuberc Lung Dis 14:160-4. 2010
    ..National Reference Laboratory, Benin...
  74. ncbi Bead-based multiplexed immunoassays to identify new biomarkers in maternal serum to improve first trimester Down syndrome screening
    M P H Koster
    Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment RIVM, 3720 BA Bilthoven, The Netherlands
    Prenat Diagn 29:857-62. 2009
    ..To identify new discriminative biomarkers for Down syndrome (DS) pregnancies using a bead-based multiplexed immunoassay, and to use the newly identified biomarkers to construct a prediction model for non-invasive DS screening...
  75. ncbi False positive reactions for IgA and IgG anti-tissue transglutaminase antibodies in liver cirrhosis are common and method-dependent
    Danilo Villalta
    Immunologia Clinica e Virologia, Azienda Ospedaliera, S Maria degli Angeli, Via Montereale 24, 33170 Pordenone, Italy
    Clin Chim Acta 356:102-9. 2005
    ..In order to establish whether this was attributable to methodological differences, anti-tTG antibodies were assayed in a large number of patients suffering from liver cirrhosis (LC)...
  76. ncbi Estimating the cumulative risk of a false-positive under a regimen involving various types of cancer screening tests
    Stuart G Baker
    Division of Cancer Prevention, National Cancer Institute, 6130 Executive Blvd MSC 7354, Bethesda, MD 20892 7354, USA
    J Med Screen 15:18-22. 2008
    ..Previous methods for estimating cumulative risk of FPs with a single type of test are not directly applicable, so a new approach was developed...
  77. ncbi Clinical utility and characteristics of nine anti-HCV antibody screening reagents used in Japan
    Mifumi Kita
    Department of Clinical Laboratory, Otemae Hospital, Osaka, Japan
    Clin Lab 55:9-22. 2009
    ..Each anti-HCV antibody screening reagent in use has unique features, and it is suggested that caution be used when diagnosing HCV infection on the basis of the results of a single antibody test...
  78. pmc Risk factors associated with false positive HIV test results in a low-risk urban obstetric population
    Tamara T Chao
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    J Pregnancy 2012:841979. 2012
    ..To examine risk factors for false positive HIV enzyme immunoassay (EIA) testing at delivery...
  79. ncbi A review of the psychosocial effects of false-positive results on parents and current communication practices in newborn screening
    J Hewlett
    Division of Genetics, Children s Hospital Boston, Massachusetts, USA
    J Inherit Metab Dis 29:677-82. 2006
    ..Communication strategies with sample materials are proposed...
  80. ncbi Prospective study of breast tomosynthesis as a triage to assessment in screening
    Daniela Bernardi
    UO Senologia Clinica e Screening Mammografico, Dipartimento di Radiodiagnostica, APSS, Via Degasperi, 79, 38100 Trento, Italy
    Breast Cancer Res Treat 133:267-71. 2012
    ..Future studies of 3D mammography should further assess its role as a recall-reducing strategy in screening practice and should include formal cost-analysis...
  81. ncbi Radioiodine therapy for thyroid cancer depicted uterine leiomyoma
    Kenji Hirata
    Department of Nuclear Medicine, Graduate School of Medicine, Sapporo, Japan
    Clin Nucl Med 34:180-1. 2009
    ..We suggest that uterine leiomyoma might be added to the pitfall list, although the mechanism of I-131 uptake remains unclear...
  82. ncbi Very low hepatitis C antibody levels predict false-positive results and avoid supplemental testing
    Ana M Contreras
    Health Research Council in Jalisco State, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico
    Transfusion 48:2540-8. 2008
    ....
  83. ncbi Focal F-18 fluoro-deoxy-glucose accumulation in the lung parenchyma in the absence of CT abnormality in PET/CT
    Dimitrios Karantanis
    Division of Nuclear Medicine, Department of Radiology, Mayo Clinic, Rochester, MN, USA
    J Comput Assist Tomogr 31:800-5. 2007
    ..To demonstrate 3 cases of artifactual focal F-18 fluoro-deoxy-glucose accumulation in the lung parenchyma in the absence of any computed tomographic (CT) abnormality...
  84. ncbi False-positive I-131 accumulation in a hepatic hydatid cyst
    Ozgur Omur
    Department of Nuclear Medicine, Ege University Medical Faculty, Bornova Izmir, Turkey
    Clin Nucl Med 32:930-2. 2007
    ..Hepatic cystic mass was removed, and postoperative histologic evaluation confirmed hydatid disease. Some cystic lesions of the kidney and liver have been previously reported as causes of false-positive radioiodine accumulation...
  85. ncbi False positives in imaging genetics
    Andreas Meyer-Lindenberg
    Unit for Systems Neuroscience in Psychiatry, National Institute for Mental Health, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892 1365, USA
    Neuroimage 40:655-61. 2008
    ..In fact, our observations indicate that these statistical thresholds are conservative...
  86. pmc Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine
    Chenghai Xue
    Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China
    BMC Bioinformatics 6:310. 2005
    ..Being able to classify real vs. pseudo pre-miRNAs is important both for understanding of the nature of miRNAs and for developing ab initio prediction methods that can discovery new miRNAs without known homology...
  87. ncbi Effect of false-positives and women's characteristics on long-term adherence to breast cancer screening
    R Roman
    Department of Epidemiology and Evaluation, Institut Municipal d Investigació Mèdica Parc de Salut Mar, Mar Teaching Hospital, 25 29 Passeig Maritim, 08003 Barcelona, Spain
    Breast Cancer Res Treat 130:543-52. 2011
    ..These findings may be useful in providing women with accurate information and in improving the effectiveness of screening programs...
  88. ncbi Reduction of the false-positive rate in newborn screening by implementation of MS/MS-based second-tier tests: the Mayo Clinic experience (2004-2007)
    D Matern
    Biochemical Genetics Laboratory, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Inherit Metab Dis 30:585-92. 2007
    ..09%, a positive predictive value of 41%, and a positive detection rate of 1 affected case in 1672 babies screened...
  89. ncbi Consensus review of discordant findings maximizes cancer detection rate in double-reader screening mammography: Irish National Breast Screening Program experience
    Colette M Shaw
    BreastCheck and Mater Misericordiae University Hospital, Dublin 7, Ireland
    Radiology 250:354-62. 2009
    ..To assesses consensus review of discordant screening mammography findings in terms of its sensitivity, safety, and effect on overall performance in the first 6 years of operation of the Irish National Breast Screening Program (NBSP)...
  90. ncbi Kernel methods for predicting protein-protein interactions
    Asa Ben-Hur
    Department of Genome Sciences, University of Washington Seattle, WA, USA
    Bioinformatics 21:i38-46. 2005
    ....
  91. ncbi Influence of urinary tract instrumentation and inflammation on the performance of urine markers for the detection of bladder cancer
    Tilman Todenhöfer
    Department of Urology, University Hospital, Tuebingen, Germany
    Urology 79:620-4. 2012
    ..The specificity of urine markers for urothelial cancer is subject to exogenous factors. There is evidence that nuclear matrix protein 22 (NMP22) is influenced by urinary tract infection and instrumented urinary sampling (IUS)...
  92. ncbi The value of FDG-PET/CT in assessing single pulmonary nodules in patients at high risk of lung cancer
    Olga Kagna
    Department of Nuclear Medicine, Ramban Health Care Campus, Technion, Israel Institute of Technology, Haifa, Israel
    Eur J Nucl Med Mol Imaging 36:997-1004. 2009
    ..To evaluate whether PET/low-dose CT (ldCT) using (18)F-fluorodeoxyglucose (FDG) improves characterization of indeterminate single pulmonary nodules (SPNs) in patients at high risk of lung cancer...
  93. ncbi Clinical issues and frequent questions about biotinidase deficiency
    Barry Wolf
    Department of Medical Genetics, Henry Ford Hospital, 3031 West Grand Blvd, Suite 700, Detroit, MI 48202, USA
    Mol Genet Metab 100:6-13. 2010
    ..In this paper, many of these issues are addressed using evidence-based medicine and anecdotal experiences. If adequate answers are not known, the answers to these queries will require future investigations...
  94. ncbi Review of false-positive cultures for Mycobacterium tuberculosis and recommendations for avoiding unnecessary treatment
    W J Burman
    Department of Public Health, Denver Health and Hospital Authority, CO, USA
    Clin Infect Dis 31:1390-5. 2000
    ..Laboratories and tuberculosis control programs should develop procedures to identify patients having only 1 positive culture. Such patients should be further evaluated for the possibility of a false-positive culture...
  95. ncbi Mastopathic-type fibroadenoma and ductal adenoma of the breast with false-positive fluorodeoxyglucose positron emission tomography
    Rin Yamaguchi
    Department of Pathology, Kurume University Medical Center, Kurume, Japan
    Jpn J Radiol 27:280-4. 2009
    ..5 on PET. It was diagnosed as fibroadenoma of mastopathic type histopathologically by excisional biopsy. The readers should be aware that these benign tumors may cause false-positive results on PET...
  96. pmc Computerized detection of lung nodules in thin-section CT images by use of selective enhancement filters and an automated rule-based classifier
    Qiang Li
    Department of Radiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Acad Radiol 15:165-75. 2008
    ..We have been developing a computer-aided diagnostic (CAD) scheme for lung nodule detection in order to assist radiologists in the detection of lung cancer in thin-section computed tomography (CT) images...
  97. pmc Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya
    Colin Ohrt
    Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    Malar J 6:79. 2007
    ..The primary objective was to ensure valid clinical trial and diagnostic test evaluations. Key secondary objectives were technology transfer to host countries, establishment of partnerships, and training of clinical microscopists...
  98. pmc Evaluation of the Palutop+4 malaria rapid diagnostic test in a non-endemic setting
    David P J van Dijk
    Faculty of Health, Medicine and Life Sciences FHML, Maastricht, The Netherlands
    Malar J 8:293. 2009
    ....
  99. ncbi Observations on false positive reactions in the rapid NOW Filariasis card test
    Paul E Simonsen
    Danish Bilharziasis Laboratory, Charlottenlund, Denmark
    Trop Med Int Health 9:1200-2. 2004
    ..Concern has been raised that a high proportion of infection negative individuals develop false positive reactions in these tests when the test cards are left for a prolonged period before being examined...
  100. ncbi Influenza vaccination and false positive HIV results
    Christian P Erickson
    N Engl J Med 354:1422-3. 2006
  101. ncbi Rapid versus standard testing for prenatal HIV screening in a predominantly Hispanic population
    C S Tung
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77018, USA
    J Perinatol 30:30-2. 2010
    ..This study aimed to examine the false positive rate of the OraQuick rapid human immunodeficiency virus (HIV) test compared with the ELISA test in pregnant patients of low socioeconomic status...

Research Grants78

  1. CHEMOTHERAPY DECISIONS AND OUTCOMES FOR THE ELDERLY
    Jeanne Mandelblatt; Fiscal Year: 2005
    ..Interventions derived from this project, hold the promise of improving the quality of care for the fastest growing segment of the breast cancer population. ..
  2. 3D Massive Training ANN for CAD for Colon Cancer in CT Colonography
    Kenji Suzuki; Fiscal Year: 2010
    ....
  3. HORMONE REPLACEMENT THERAPY AND BREAST CANCER
    Patricia Carney; Fiscal Year: 2004
    ..abstract_text> ..
  4. PREVALENCE EFFECT IN IMAGING SYSTEMS EVALUATIONS
    David Gur; Fiscal Year: 2001
    ..abstract_text> ..
  5. A first-responder EEG device for seizure management in a nerve gas attack
    Scott Wilson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. ROC Analysis of Imaging System Evaluations
    David Gur; Fiscal Year: 2009
    ..We will develop closed-form solutions for the ANOVA procedure conducted on all possible bootstrap values. ..
  7. Multimodality CAD system with image references for breast mass characterization
    Berkman Sahiner; Fiscal Year: 2007
    ..Any reduction in this number without a decrease in breast cancer detection sensitivity will decrease health care costs, as well as contribute to the well-being of the patient by reducing anxiety and morbidity. ..
  8. Perception and Inter-Observer Variability in Mammography
    Claudia Mello Thoms; Fiscal Year: 2005
    ..In addition, the changes in sampling strategy will correspond to actual possible strategies for the human observers themselves. ..
  9. Statistical Methods for Identifying Genes Associated with Diabetes Development
    Yinglei Lai; Fiscal Year: 2007
    ..R-package based computer programs will be developed, tested, documented, and freely distributed to the scientific community. [unreadable] [unreadable] [unreadable]..
  10. Assessment of Variance Structure in ROC Studies
    David Gur; Fiscal Year: 2006
    ..e., those that are the less demanding of the expensive resources of gathering patient cases and expanding radiologists reading time. ..
  11. ROC Analysis of Imaging System Evaluations
    David Gur; Fiscal Year: 2002
    ..abstract_text> ..
  12. The Laboratory Effect in Breast Cancer Detection Studies
    David Gur; Fiscal Year: 2007
    ..The comparison we are attempting to do is at the very core of our ability (or not) to generalize laboratory observer performance data to the general clinical environment in a valid manner. ..
  13. Integrated Top-Down/Bottom-Up Comprehensive Proteomics
    Satya Saxena; Fiscal Year: 2007
    ..Research efforts in the R43 phase will address early implementation, optimization, and demonstration of the proposed proteome technology using yeast cell lysates. ..
  14. Comparing Performance Under FROC Paradigm - A Non Parametirc Approach
    David Gur; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Network Topology in Cell Signaling
    Norbert Perrimon; Fiscal Year: 2008
    ..Altogether, these studies will greatly advance our knowledge of signaling networks and their organization during signal transduction. [unreadable] [unreadable] [unreadable]..
  16. UNDERSTANDING VARIABILITY IN COMMUNITY MAMMOGRAPHY
    Joann Elmore; Fiscal Year: 2008
    ..This work builds on our previous model development and is a natural extension in a timely and important clinical area. [unreadable] [unreadable]..
  17. fMRI ABILITY TO MAP COLUMNAR STRUCTURES IN HUMANS
    Essa Yacoub; Fiscal Year: 2008
    ..Finally, the existence of orientation columns in humans, which has never been shown, can be addressed using fMRI techniques developed in this work. [unreadable] [unreadable]..
  18. Computer-Aided Detection of Pulmonary Embolism on CT Pulmonary Angiography
    Chuan Zhou; Fiscal Year: 2007
    ..CAD will potentially reduce missed PEs and improve the chance of timely treatment of patients, thus reducing the mortality rate and speed up recovery from this condition. [unreadable] [unreadable]..
  19. COORDINATING CENTER FOR AMD PREVENTION TRIAL
    Maureen Maguire; Fiscal Year: 2006
    ..Design and implement a full program of quality assurance activities; . Design and implement studies of quality of life assessment; . Assist with the preparation of scientific reports. ..
  20. Benefits and Burdens of Screening Oldest-old Women: the Case of Mammography
    MARA SCHONBERG; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  21. Software For The Analysis Of Hormone Pulsatility
    Michael Johnson; Fiscal Year: 2008
    ..We also envision potential applications in other non-endocrine research fields. ..
  22. Cysteine, Related Gene Variants and Breast Cancer Risk
    Walter C Willett; Fiscal Year: 2010
    ....
  23. FUNCTIONAL MRI IN HUMANS AT 7 TESLA
    Essa Yacoub; Fiscal Year: 2010
    ..4 Tesla for the first time in humans. Furthermore, we will systematically compare the advantages of higher field systems with lower field systems (3 T) for general applications. ..
  24. Preventing the Incidentalome
    Isaac S Kohane; Fiscal Year: 2010
    ..Evidence supporting this hypothesis will both serve as an important caution in the use of genetic testing and will also demonstrate the value of population studies to find the broader clinical significance of genetic mutations. ..
  25. Affect Labeling Expressive Writing and Emotion Regulation
    Matthew Dylan Lieberman; Fiscal Year: 2010
    ....
  26. A genome-wide association study to detect genetic variation for schizophrenia
    Edwin van den Oord; Fiscal Year: 2010
    ..We attempt to contribute to the rigorous evaluation of the common disease/common genetic variant model for schizophrenia, which is key to further understand its pathophysiology and develop effective treatments. ..
  27. Analysis and Statistical Validation of Proteomic Datasets
    Alexey Nesvizhskii; Fiscal Year: 2009
    ....
  28. CHARACTERIZATION OF PRODROMAL SCHIZOPHRENIA
    Barbara Cornblatt; Fiscal Year: 2009
    ..This design is expected to provide the prospective evidence base essential to develop effective, stage-specific interventions targeting a broad spectrum of outcomes. Prevention of psychosis remains a very long-term goal. ..
  29. COMPUTERIZED RADIOGRAPHIC ANALYSIS OF BONE STRUCTURE
    Maryellen Giger; Fiscal Year: 2009
    ..We expect that with this grant renewal, we will be able to complete the research with a focus on translation of the results into the clinical arena. ..
  30. The Feasibility of Earlier Detection of Ovarian Cancer Using Symptom Reports
    Marin Andersen; Fiscal Year: 2009
    ..Outcomes of such an approach for women with and without the identified pattern of symptoms will be examined. ..
  31. Host factors involved in bacterial pathogenesis
    Norbert Perrimon; Fiscal Year: 2009
    ..tuberculosis and its human host. ..
  32. Spatio-Temporal Epidemiology: Methods and Applications
    Jonathan Wakefield; Fiscal Year: 2008
    ..S. cancer incidence and mortality data, and Washington State small-area cancer incidence data. Developed methods will be made available to researchers via implementation within freely-available software. ..
  33. Gene Polymorphism & Treatment-Symptoms in Lung Cancer
    Cielito Reyes Gibby; Fiscal Year: 2008
    ..abstract_text> ..
  34. Epigenetic Effects of Resveratrol
    Edward Sauter; Fiscal Year: 2008
    ..As more and more Americans turn to nutraceuticals for a healthier lifestyle, studies like these are increasingly important in the fight against cancer. [unreadable] [unreadable] [unreadable]..
  35. Viral Immunity in Drosophila
    Norbert Perrimon; Fiscal Year: 2007
    ..Because our insect virus system is sensitive to drugs that are used against human viruses, our studies may lead to the identification of novel antiviral compounds that may prove effective in mammalian cells. ..
  36. Neurodevelopment and HIV/AIDS
    Annelies Van Rie; Fiscal Year: 2005
    ....
  37. Mammography Screening Decisions in the Elderly
    MARA SCHONBERG; Fiscal Year: 2005
    ..This is the first study to explore very elderly women's approach to decisions about screening mammography. ..
  38. HIV-Infected IDU Living with HCV Coinfection
    Karolynn Siegel; Fiscal Year: 2005
    ..abstract_text> ..
  39. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    Paul Stein; Fiscal Year: 2003
    ..4) The team of investigators is strong, and has collaborated previously in successful research in PE. ..
  40. Treatment Models for Primary and Chronic HIV Infection
    Rochelle Walensky; Fiscal Year: 2005
    ..Rochelle Walensky with a firm basis for career development as an independent, patient-oriented clinical researcher at the interface of these critical areas. ..
  41. COMPUTER AIDED DIAGNOSIS IN BREAST IMAGING
    Maryellen Giger; Fiscal Year: 2005
    ..We believe that with the combined information from multimodality imaging and clinical information, overall patient outcome will improve. ..
  42. Statistical Design & Analysis of Microarray Experiments
    Sandrine Dudoit; Fiscal Year: 2004
    ..To facilitate use and integration with biological information resources a web-browser interface will be provided. ..
  43. OBSERVER PERFORMANCE STUDIES-READER SELECTION & TRAINING
    David Gur; Fiscal Year: 2002
    ..While they proposed to continue to investigate several aspects in this regard, the current proposal would focus on the possible effects of observer (reader) selection and training on study design and results. ..
  44. Early Detection of Lung Cancer via Bi Plane Correlation
    Ehsan Samei; Fiscal Year: 2002
    ..The findings will be used to demonstrate the capability of the approach for improving the detection of lung nodules, and thus the prognosis of lung cancer. ..
  45. Symptom Interpretation & Oral Health among Harlem Adults
    Karolynn Siegel; Fiscal Year: 2005
    ..In depth face-to-face, focused interviews will be conducted with 120 adults. As in several of the principal Investigator's previous federally funded investigations, qualitative research methods will be employed. ..
  46. Treatment and Outcome of AIDS-related Lymphoma
    Catherine Diamond; Fiscal Year: 2006
    ..Lastly, we will determine how the use of HAART influences the IPI and develop a prognostic model that incorporates HIV-related factors, tumor characteristics, HAART, and chemotherapy. ..
  47. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  48. ENOS & THE RADICAL MECHANISM OF ANTITUMOR ANTHRACYCLINES
    Balaraman Kalyanaraman; Fiscal Year: 2006
    ..Understanding the relationship between DOX-induced apoptosis and ROS formation may help discover novel antioxidant/antiapoptotic therapy in oxidant-induced disease processes. ..
  49. Identification of Differentially Expressed Proteomes in Human Astrocytomas
    BRIAN BALGLEY; Fiscal Year: 2006
    ..g. grade II to grade III. [unreadable] [unreadable] [unreadable]..
  50. Psychiatric Genetics and Family Studies: Robust Methods
    Susan E Hodge; Fiscal Year: 2010
    ..Relevance: This work will contribute to public health by developing improved methods for identifying genes and understanding the genetics of common, complex diseases, including, but not limited to, psychiatric diseases. ..
  51. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2005
    ..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
  52. Interactive CAD for Mammography
    Bin Zheng; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  53. PERCEPTUAL MODEL FOR WORKSTATION DISPLAY OPTIMIZATION
    Dev Chakraborty; Fiscal Year: 2002
    ..Also to be generated are iso-contour plots of the effects of common workstation variables on image quality in both tasks. This will allow digital mammography workstations to be more intelligently used. ..
  54. Design and analysis of adaptive multistage genetic association studies
    Edwin van den Oord; Fiscal Year: 2010
    ..The goal of this project is to develop a flexible framework for designing these studies in a cost-effective way and optimize subsequent replication efforts. ..
  55. Peroxide, NO and Iron Signaling in Endothelial Damage
    Balaraman Kalyanaraman; Fiscal Year: 2007
    ..Novelty: This proposal presents a new insight on peroxide-induced iron signaling in endothelial apoptosis and on the role of NO and antioxidants in mitigating these effects. ..
  56. Development of a Wearable Seizure Warning Device
    GEORGIY MINASYAN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  57. TAMOXIFEN & BREAST CANCER--ACCEPTANCE/COST EFFECTIVENESS
    Joy Melnikow; Fiscal Year: 2002
    ..abstract_text> ..
  58. Surveillance Strategies Following Treatment for CIN
    Joy Melnikow; Fiscal Year: 2007
    ..Alternative strategies for post-treatment surveillance will be evaluated. [unreadable] [unreadable] [unreadable]..
  59. Resource and QOL Consequences of Lung Cancer Screening
    Margaret Byrne; Fiscal Year: 2007
    ..abstract_text> ..
  60. GENETICS OF AD PARTIAL EPILEPSY WITH AUDITORY FEATURES
    Ruth Ottman; Fiscal Year: 2007
    ..abstract_text> ..
  61. Bicarbonate Enhances Peroxidation of SOD/ALS Mutants
    Balaraman Kalyanaraman; Fiscal Year: 2008
    ....
  62. STATISTICAL METHODS FOR COMMUNITY INTERVENTION TRIALS
    Ziding Feng; Fiscal Year: 2003
    ..The bias and efficiency of this method compared to competing procedures will be examined analytically and via simulation. ..
  63. Polymyxin-resistant Pseudomonas in CF Lung Infection
    Samuel M Moskowitz; Fiscal Year: 2010
    ..An interdisciplinary study of polymyxin resistant Pseudomonas from patients with cystic fibrosis is proposed to pinpoint the bacterial genes responsible for this resistance, so that management strategies may be devised to overcome it. ..
  64. Eicosanoids and the Outflow Pathways of the Eye
    Robert Weinreb; Fiscal Year: 2008
    ..The results of these studies have important implications for the discovery of new treatments for glaucoma and other vision-threatening eye diseases. ..
  65. ACC in Neuroticism and Social Cognition
    MATTHEW LIEBERMAN; Fiscal Year: 2003
    ..abstract_text> ..
  66. Treating PTSD in Children Exposed to Domestic Violence
    Judith Cohen; Fiscal Year: 2008
    ..abstract_text> ..
  67. Neural Mechanisms Underlying Stress Reactivity
    MATTHEW LIEBERMAN; Fiscal Year: 2006
    ..Supportive evidence will flesh out the neural mechanisms through which individual differences affect biological responses to stress and elucidate the risk factors for stress- related mental and physical health problems. ..
  68. Quantitative Cross-Species Approaches to Gene Regulation
    LEE NEWBERG; Fiscal Year: 2007
    ..A K25 award will enable Newberg to become a high-quality independent investigator and will move us towards a greater understanding of cellular function. ..
  69. GENETIC EPIDEMIOLOGY OF FAMILIAL EPILEPSY
    Ruth Ottman; Fiscal Year: 2001
    ..g., generalized epilepsy, localization-related epilepsy). ..
  70. UNDERSTANDING VARIABILITY IN COMMUNITY MAMMOGRAPHY
    Joann Elmore; Fiscal Year: 2002
    ..Gaining a better understanding of how individual radiologists and their practice environment account for variation will help identify ways to improve mammography. ..
  71. Phonetic and prosodic effects in perceptual assimilation
    JAMES HARNSBERGER; Fiscal Year: 2005
    ....
  72. GENETIC EPIDEMIOLOGY OF SEIZURE DISORDERS IN ROCHESTER
    Ruth Ottman; Fiscal Year: 2006
    ..abstract_text> ..
  73. Pharmacologic Treat. of PTSD in Sexually Abused Children
    Judith Cohen; Fiscal Year: 2005
    ....