optical coherence tomography

Summary

Summary: An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.

Top Publications

  1. doi Enhanced depth imaging spectral-domain optical coherence tomography
    Richard F Spaide
    Vitreous Retina Macula Consultants of New York, LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 146:496-500. 2008
  2. ncbi An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    Anne E Fung
    Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
    Am J Ophthalmol 143:566-83. 2007
  3. doi A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes
    Ron Margolis
    Vitreous Retina Macula Consultants of New York, New York, New York 10022, USA
    Am J Ophthalmol 147:811-5. 2009
  4. ncbi Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography
    Johannes F de Boer
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
    Opt Lett 28:2067-9. 2003
  5. pmc Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography
    Vivek J Srinivasan
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Invest Ophthalmol Vis Sci 47:5522-8. 2006
  6. pmc Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography
    Maciej Wojtkowski
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 112:1734-46. 2005
  7. ncbi Early detection of retinal thickness changes in diabetes using Optical Coherence Tomography
    Delia Cabrera DeBuc
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 900 NW 17 Street, Miami, FL 33136, USA
    Med Sci Monit 16:MT15-21. 2010
  8. doi Foveal microstructure and visual acuity after retinal detachment repair: imaging analysis by Fourier-domain optical coherence tomography
    Taku Wakabayashi
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 116:519-28. 2009
  9. pmc Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies
    J N Ratchford
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurology 73:302-8. 2009
  10. pmc Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second
    Benjamin Potsaid
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Express 16:15149-69. 2008

Detail Information

Publications409 found, 100 shown here

  1. doi Enhanced depth imaging spectral-domain optical coherence tomography
    Richard F Spaide
    Vitreous Retina Macula Consultants of New York, LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 146:496-500. 2008
    To describe a method to obtain images of the choroid using conventional spectral-domain (SD) optical coherence tomography (OCT) and to evaluate choroidal thickness measurements using these images.
  2. ncbi An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (Lucentis) for neovascular age-related macular degeneration
    Anne E Fung
    Pacific Eye Associates, California Pacific Medical Center, San Francisco, California, USA
    Am J Ophthalmol 143:566-83. 2007
    To evaluate an optical coherence tomography (OCT)-guided, variable-dosing regimen with intravitreal ranibizumab for the treatment of patients with neovascular age-related macular degeneration (AMD).
  3. doi A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes
    Ron Margolis
    Vitreous Retina Macula Consultants of New York, New York, New York 10022, USA
    Am J Ophthalmol 147:811-5. 2009
    To measure macular choroidal thickness in normal eyes at different points using enhanced depth imaging (EDI) optical coherence tomography (OCT) and to evaluate the association of choroidal thickness and age.
  4. ncbi Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography
    Johannes F de Boer
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
    Opt Lett 28:2067-9. 2003
    A signal-to-noise ratio (SNR) analysis is presented for optical coherence tomography (OCT) signals in which time-domain performance is compared with that of the spectral domain...
  5. pmc Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography
    Vivek J Srinivasan
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Invest Ophthalmol Vis Sci 47:5522-8. 2006
    To demonstrate high-speed, ultrahigh-resolution optical coherence tomography (OCT) for noninvasive, in vivo, three-dimensional imaging of the retina in rat and mouse models.
  6. pmc Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography
    Maciej Wojtkowski
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 112:1734-46. 2005
    To demonstrate high-speed, ultrahigh-resolution, 3-dimensional optical coherence tomography (3D OCT) and new protocols for retinal imaging.
  7. ncbi Early detection of retinal thickness changes in diabetes using Optical Coherence Tomography
    Delia Cabrera DeBuc
    Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 900 NW 17 Street, Miami, FL 33136, USA
    Med Sci Monit 16:MT15-21. 2010
    ..In this study, the ability of intraretinal layer segmentation to locally detect early retinal changes in diabetic patients is assessed using optical coherence tomography (OCT).
  8. doi Foveal microstructure and visual acuity after retinal detachment repair: imaging analysis by Fourier-domain optical coherence tomography
    Taku Wakabayashi
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 116:519-28. 2009
    ..To evaluate foveal microstructural changes in eyes with anatomically successful repair of rhegmatogenous retinal detachments (RRDs)...
  9. pmc Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies
    J N Ratchford
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurology 73:302-8. 2009
    To evaluate the retinal nerve fiber layer (RNFL) thickness and macular volume in neuromyelitis optica (NMO) spectrum patients using optical coherence tomography (OCT).
  10. pmc Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second
    Benjamin Potsaid
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Opt Express 16:15149-69. 2008
    We demonstrate ultrahigh speed spectral / Fourier domain optical coherence tomography (OCT) using an ultrahigh speed CMOS line scan camera at rates of 70,000 - 312,500 axial scans per second...
  11. pmc Keratoconus diagnosis with optical coherence tomography pachymetry mapping
    Yan Li
    Center for Ophthalmic Optics and Lasers, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 99033, USA
    Ophthalmology 115:2159-66. 2008
    To detect abnormal corneal thinning in keratoconus using pachymetry maps measured by high-speed anterior segment optical coherence tomography (OCT).
  12. pmc Spectral domain optical coherence tomography in mouse models of retinal degeneration
    Gesine Huber
    Division of Ocular Neurodegeneration, Institute for Ophthalmic Research, Centre for Ophthalmology, Tuebingen, Germany
    Invest Ophthalmol Vis Sci 50:5888-95. 2009
    Spectral domain optical coherence tomography (SD-OCT) allows cross-sectional visualization of retinal structures in vivo...
  13. doi Enhanced depth imaging optical coherence tomography of the choroid in highly myopic eyes
    Takamitsu Fujiwara
    The Vitreous, Retina, Macula Consultants of New York and LuEsther T Mertz Retina Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 148:445-50. 2009
    To measure macular choroidal thickness (CT) in highly myopic eyes using enhanced depth imaging optical coherence tomography (OCT).
  14. ncbi An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008
    ..is composed largely of unmyelinated axons of retinal ganglion cells, and is accessible to study with optical coherence tomography (OCT), giving a measure of axonal loss...
  15. doi Optical coherence tomography in clinically isolated syndrome: no evidence of subclinical retinal axonal loss
    Olivier Outteryck
    Department of Neurology, Universite Lille Nord de France, Lille, France
    Arch Neurol 66:1373-7. 2009
    b>Optical coherence tomography has emerged as a new tool for quantifying axonal loss in multiple sclerosis (MS)...
  16. ncbi Speckle variance detection of microvasculature using swept-source optical coherence tomography
    Adrian Mariampillai
    Department of Medical Biophysics, University of Toronto, Toronto, M5G 2M9, Canada
    Opt Lett 33:1530-2. 2008
    We report on imaging of microcirculation by calculating the speckle variance of optical coherence tomography (OCT) structural images acquired using a Fourier domain mode-locked swept-wavelength laser...
  17. ncbi In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography
    Nader Nassif
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
    Opt Lett 29:480-2. 2004
    An ultrahigh-speed spectral domain optical coherence tomography (SD-OCT) system is presented that achieves acquisition rates of 29,300 depth profiles/s...
  18. pmc Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography
    M Dominik Fischer
    Division of Ocular Neurodegeneration, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
    PLoS ONE 4:e7507. 2009
    b>Optical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue sections in mouse models of retinal degeneration.
  19. doi Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy
    Yutaka Imamura
    Vitreous Retina Macula Consultants of New York, New York, NY 10022, USA
    Retina 29:1469-73. 2009
    ..The purpose of the study was to evaluate the choroidal thickness in patients with central serous chorioretinopathy, a disease attributed to increased choroidal vascular hyperpermeability...
  20. doi Relationship between retinal nerve fiber layer measurement and signal strength in optical coherence tomography
    Carol Yim Lui Cheung
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
    Ophthalmology 115:1347-51, 1351.e1-2. 2008
    To examine the relationship between signal strength and retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT).
  21. ncbi Detection of early diabetic change with optical coherence tomography in type 2 diabetes mellitus patients without retinopathy
    Masahiko Sugimoto
    Department of Ophthalmology, Mie University, School of Medicine, Tsu, Japan
    Ophthalmologica 219:379-85. 2005
    To detect early diabetic damage in type 2 diabetes mellitus patients with no diabetic retinopathy (NDR) using optical coherence tomography (OCT) and to evaluate OCT as a clinical test.
  22. doi Inner segment/outer segment junction assessed by spectral-domain optical coherence tomography in patients with idiopathic epiretinal membrane
    Maiko Inoue
    Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan
    Am J Ophthalmol 150:834-9. 2010
    ..of the photoreceptor inner/outer segment (IS/OS) junction before and after surgery by spectral-domain optical coherence tomography in patients undergoing idiopathic epiretinal membrane (ERM) surgery and to correlate these features ..
  23. doi Three-dimensional high-speed optical coherence tomography imaging of lamina cribrosa in glaucoma
    Ryo Inoue
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ophthalmology 116:214-22. 2009
    ..of the optic nerve head and lamina cribrosa in patients with glaucoma using spectral/Fourier-domain optical coherence tomography (SD-OCT) and to test for a correlation between lamina cribrosa thickness measured on SD-OCT images and ..
  24. pmc Spectral domain optical coherence tomography for glaucoma (an AOS thesis)
    Joel S Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Trans Am Ophthalmol Soc 106:426-58. 2008
    b>Optical coherence tomography (OCT) is a rapidly evolving, robust technology that has profoundly changed the practice of ophthalmology...
  25. ncbi Quantitative ex vivo and in vivo comparison of lumen dimensions measured by optical coherence tomography and intravascular ultrasound in human coronary arteries
    Nieves Gonzalo
    Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, Paises Bajos
    Rev Esp Cardiol 62:615-24. 2009
    ..obtained in human coronary arteries using intravascular ultrasound (IVUS) and those obtained using optical coherence tomography (OCT) is not well understood...
  26. pmc Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography
    Yimin Wang
    University of Southern California, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, Los Angeles, California 90033, USA
    J Biomed Opt 13:064003. 2008
    We present in vivo human total retinal blood flow measurements using Doppler Fourier domain optical coherence tomography (OCT)...
  27. doi Optical distortion correction in optical coherence tomography for quantitative ocular anterior segment by three-dimensional imaging
    Sergio Ortiz
    Instituto de Optica Daza de Valdes, Consejo Superior de Investigaciones Cientificas, 28006 Madrid, Spain
    Opt Express 18:2782-96. 2010
    A method for three-dimensional 3-D optical distortion (refraction) correction on anterior segment Optical Coherence Tomography (OCT) images has been developed...
  28. pmc Volumetric retinal imaging with ultrahigh-resolution spectral-domain optical coherence tomography and adaptive optics using two broadband light sources
    Barry Cense
    Indiana University, School of Optometry, 800 E Atwater Avenue, Bloomington, Indiana 47405, USA
    Opt Express 17:4095-111. 2009
    ..diodes (SLDs) and femtosecond lasers, have been successfully employed in adaptive optics optical coherence tomography (AO-OCT) systems for ultrahigh resolution retinal imaging...
  29. ncbi Spectral-domain optical coherence tomography with multiple B-scan averaging for enhanced imaging of retinal diseases
    Atsushi Sakamoto
    Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Ophthalmology 115:1071-1078.e7. 2008
    To determine whether multiple B-scan averaging improves the quality of spectral-domain optical coherence tomography (SD OCT) images of the retina.
  30. ncbi State-of-the-art retinal optical coherence tomography
    Wolfgang Drexler
    Biomedical Imaging Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, CF24 4LU, Wales, United Kingdom
    Prog Retin Eye Res 27:45-88. 2008
    ..as well as high-speed Fourier detection techniques, has enabled a significant improvement in ophthalmic optical coherence tomography (OCT) imaging performance...
  31. ncbi Advances in optical coherence tomography imaging for dermatology
    Mark C Pierce
    Wellman Center for Photomedicine Harvard Medical School, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
    J Invest Dermatol 123:458-63. 2004
    b>Optical coherence tomography (OCT) is a non-invasive imaging technique, which has previously demonstrated potential for use in dermatology...
  32. ncbi Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases
    Ursula Schmidt-Erfurth
    Department of Ophthalmology, General Hospital of Vienna, Medical University of Vienna, Waehringer Strasse 13, A 1090 Vienna, Austria
    Invest Ophthalmol Vis Sci 46:3393-402. 2005
    To demonstrate a new generation of three-dimensional (3-D) ultrahigh-resolution optical coherence tomography (UHR OCT) technology for visualization of macular diseases.
  33. ncbi In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography
    Marco Ruggeri
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 N W 10th Avenue, Miami, FL 33136, USA
    Invest Ophthalmol Vis Sci 48:1808-14. 2007
    To demonstrate the application of high-resolution spectral-domain optical coherence tomography (SD-OCT) for three-dimensional (3D) retinal imaging of small animals and quantitative retinal information extraction using 3D segmentation of ..
  34. pmc Intraoperative evaluation of breast tumor margins with optical coherence tomography
    Freddy T Nguyen
    Departments of Chemistry, College of Medicine, and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Illinois 61801, USA
    Cancer Res 69:8790-6. 2009
    ..b>Optical coherence tomography (OCT) is introduced as an intraoperative high-resolution imaging technique that assesses surgical ..
  35. pmc Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT
    Lelia A Paunescu
    New England Eye Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 45:1716-24. 2004
    The measurement reproducibility of the third generation of commercial optical coherence tomography, OCT-3 (StratusOCT, software ver. A2, Carl Zeiss Meditec Inc., Dublin, CA) was investigated...
  36. ncbi Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study
    Christopher K S Leung
    Department of Ophthalmology, Caritas Medical Centre, Hong Kong, China
    Ophthalmology 112:391-400. 2005
    To evaluate macular nerve fiber layer (NFL) thickness in glaucomatous damage by optical coherence tomography (OCT) and to compare its discriminating power for glaucoma and glaucoma suspects with that of total macular thickness and ..
  37. ncbi Quantifying axonal loss after optic neuritis with optical coherence tomography
    Fiona Costello
    Division of Neurology, Ottawa, Ontario Canada
    Ann Neurol 59:963-9. 2006
    ..To determine to what degree changes in retinal nerve fiber layer (RNFL) thickness after optic neuritis (ON) correlate with either visual recovery or impairment...
  38. pmc Comparison of anterior chamber depth measurements using the IOLMaster, scanning peripheral anterior chamber depth analyser, and anterior segment optical coherence tomography
    Raghavan Lavanya
    Glaucoma Department, Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751
    Br J Ophthalmol 91:1023-6. 2007
    ..IOLMaster, scanning peripheral anterior chamber depth analyser (SPAC), and Visante anterior segment optical coherence tomography (AS-OCT) METHODS: Prospective, cross sectional study of 497 phakic subjects over 50 years of age ..
  39. pmc Quantitative optical coherence tomography findings in various subtypes of neovascular age-related macular degeneration
    Sandra Liakopoulos
    Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 49:5048-54. 2008
    To compare the volume of various spaces visible on optical coherence tomography (OCT) images in different angiographic lesion subtypes of neovascular age-related macular degeneration (AMD).
  40. ncbi The repeatability of corneal and corneal epithelial thickness measurements using optical coherence tomography
    Sokpheaktra Sin
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Optom Vis Sci 83:360-5. 2006
    The purpose of this study is to examine within and between session repeatability of clinical optical coherence tomography (OCT) imaging for anterior segment morphometry.
  41. doi Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis
    Harsha L Rao
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, California 92093 0946, USA
    Ophthalmology 117:1692-9, 1699.e1. 2010
    ..To evaluate retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular thickness measurements for glaucoma detection using the RTVue spectral domain optical coherence tomograph...
  42. pmc In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: preliminary studies in 50 patients
    Petra Wilder-Smith
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 41:353-7. 2009
    In vivo, non-invasive optical coherence tomography (OCT) permits high-resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies.
  43. doi Comparison of retinal thickness in normal eyes using Stratus and Spectralis optical coherence tomography
    Sandeep Grover
    Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL 32209, USA
    Invest Ophthalmol Vis Sci 51:2644-7. 2010
    Spectral-domain optical coherence tomography (SD-OCT) is an advancement over time-domain OCT (TD-OCT) in the imaging of retinal disorders...
  44. doi Assessment of the scleral spur in anterior segment optical coherence tomography images
    Lisandro M Sakata
    Singapore Eye Research Institute, Singapore 168751
    Arch Ophthalmol 126:181-5. 2008
    To assess visibility of the scleral spur in anterior segment optical coherence tomography (AS-OCT) images.
  45. doi Optical coherence tomography assessment of the acute effects of stent implantation on the vessel wall: a systematic quantitative approach
    N Gonzalo
    Thoraxcenter, Erasmus MC, 3015 CE Rotterdam, The Netherlands
    Heart 95:1913-9. 2009
    To observe and characterise vessel injury after stenting using optical coherence tomography (OCT), to propose a systematic OCT classification for periprocedural vessel trauma, to evaluate its frequency in stable versus unstable patients ..
  46. pmc Optical coherence tomography evaluation of zotarolimus-eluting stents at 9-month follow-up: comparison with sirolimus-eluting stents
    J S Kim
    Division of Cardiology, Yonsei Cardiovascular Centre, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, 120 752 Seoul, Korea
    Heart 95:1907-12. 2009
    ..the vascular response at 9 months after zotarolimus-eluting stent (ZES; Endeavor) implantation using optical coherence tomography (OCT)...
  47. ncbi Optical coherence tomography use in evaluation of the vitreoretinal interface: a review
    Rukhsana G Mirza
    Department of Ophthalmology, Northwestern University, Chicago, Illinois 60611 2814, USA
    Surv Ophthalmol 52:397-421. 2007
    b>Optical coherence tomography (OCT) is a valuable tool for assessment of the vitreoretinal interface. This article reviews the normal process of age-related posterior vitreous detachment as viewed by OCT...
  48. doi Thickness measurements of donor posterior disks after descemet stripping endothelial keratoplasty with anterior segment optical coherence tomography
    Carla P Nieuwendaal
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cornea 28:298-303. 2009
    To evaluate donor posterior disk thickness measured with anterior segment optical coherence tomography after Descemet stripping endothelial keratoplasty.
  49. pmc The characteristic features of optical coherence tomography in posterior uveitis
    M J Gallagher
    Massachusetts Eye Research and Surgery Institute, 5 Cambridge Center, 8th Floor, Cambridge, MA 02142, USA
    Br J Ophthalmol 91:1680-5. 2007
    ..To describe the different retinal morphological characteristics that can present on optical coherence topography (OCT) in a spectrum of uveitic diseases...
  50. pmc Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography
    Annie Chan
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass 02111 1533, USA
    Arch Ophthalmol 124:193-8. 2006
    To report normal macular thickness measurements in healthy eyes using the latest commercially available optical coherence tomography (OCT) mapping software, version 3.0, from the Stratus OCT (OCT3).
  51. doi Corneal deturgescence after Descemet stripping automated endothelial keratoplasty evaluated by Visante anterior segment optical coherence tomography
    Mario A Di Pascuale
    University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Ophthalmol 148:32-7.e1. 2009
    To evaluate postoperative corneal deturgescence after Descemet stripping endothelial keratoplasty (DSAEK) using the Visante anterior segment optical coherence tomography (OCT) system (Carl Zeiss Meditec Inc, Dublin, California, USA).
  52. doi Optical coherence tomography patterns of stent restenosis
    Nieves Gonzalo
    Thoraxcenter, Erasmus MC, Rotterdam 3015 CE, The Netherlands
    Am Heart J 158:284-93. 2009
    Stent restenosis is an infrequent but poorly understood clinical problem in the drug-eluting stent era. The aim of the study was to evaluate the morphologic characteristics of stent restenosis by optical coherence tomography (OCT).
  53. pmc Pachymetric mapping with Fourier-domain optical coherence tomography
    Yan Li
    Center for Ophthalmic Optics and Lasers, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Cataract Refract Surg 36:826-31. 2010
    To evaluate the repeatability of Fourier-domain optical coherence tomography (OCT) pachymetric mapping and compare central corneal thickness (CCT) measurements by OCT, ultrasound pachymetry, and scanning-slit tomography.
  54. doi Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study
    Won Kyung Song
    Department of Ophthalmology, Institute of Vision Research, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
    Invest Ophthalmol Vis Sci 51:3913-8. 2010
    To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT).
  55. doi High-resolution optical coherence tomography findings in optic pit maculopathy
    Yutaka Imamura
    LuEsther T Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York, USA
    Retina 30:1104-12. 2010
    The purpose of this study was to characterize retinal manifestations of optic pit maculopathy using high-resolution optical coherence tomography.
  56. doi Assessment of central corneal thickness in normal, keratoconus, and post-laser in situ keratomileusis eyes using Scheimpflug imaging, spectral domain optical coherence tomography, and ultrasound pachymetry
    Dilraj S Grewal
    Grewal Eye Institute, Chandigarh, India
    J Cataract Refract Surg 36:954-64. 2010
    ..To compare the central corneal thickness (CCT) in normal eyes, eyes with keratoconus, and eyes after laser in situ keratomileusis (LASIK) using 3 methods...
  57. pmc Refractive index measurement of the isolated crystalline lens using optical coherence tomography
    Stephen R Uhlhorn
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL, USA
    Vision Res 48:2732-8. 2008
    An optical coherence tomography system has been developed that was designed specifically for imaging the isolated crystalline lens. Cross-sectional OCT images were recorded on 40 lenses from 32 human donors with an age range of 6-82 years...
  58. ncbi Improved spectral optical coherence tomography using optical frequency comb
    Tomasz Bajraszewski
    Institute of Physics, Nicolaus Copernicus University, ul Grudziadzka 5 7, 87 100 Torun, Poland
    Opt Express 16:4163-76. 2008
    ..Spectral Optical Coherence Tomography using a method based on an optical frequency comb is demonstrated...
  59. doi Use of anterior segment optical coherence tomography to study corneal changes after collagen cross-linking
    Muriel Doors
    Department of Ophthalmology, University Medical Center Maastricht, Maastricht, The Netherlands
    Am J Ophthalmol 148:844-51.e2. 2009
    To investigate the stromal demarcation line after corneal cross-linking using anterior segment optical coherence tomography (AS-OCT) and its influence on the short-term results of cross-linking in patients with progressive keratoconus.
  60. pmc Macular segmentation with optical coherence tomography
    Hiroshi Ishikawa
    UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, PA 15213, USA
    Invest Ophthalmol Vis Sci 46:2012-7. 2005
    ..a software algorithm to perform automated segmentation of retinal layer structures on linear macular optical coherence tomography (StratusOCT; Carl Zeiss Meditec, Inc...
  61. pmc Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements
    Alberto O Gonzalez-Garcia
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California, San Diego, La Jolla, California, USA
    Am J Ophthalmol 147:1067-74, 1074.e1. 2009
    To evaluate RTVue spectral-domain optical coherence tomography (OCT) (Optovue Inc, Fremont, California, USA) reproducibility and to assess agreement with Stratus time-domain OCT (Carl Zeiss Meditec, Dublin, California, USA) measurements.
  62. ncbi Assessment of coronary arterial plaque by optical coherence tomography
    Teruyoshi Kume
    Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan
    Am J Cardiol 97:1172-5. 2006
    The purpose of this study was to analyze the ability of optical coherence tomography (OCT) to identify coronary arterial plaque diagnosed by histologic examination...
  63. doi Optical coherence tomography: high resolution intravascular imaging to evaluate vascular healing after coronary stenting
    Giulio Guagliumi
    Cardiovascular Department, Ospedali Riuniti di Bergamo, Bergamo, Italy
    Catheter Cardiovasc Interv 72:237-47. 2008
    ..b>Optical coherence tomography (OCT) enables real-time, full tomographic, in-vivo visualization of coronary vessel microstructure...
  64. pmc Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions
    Robert J Zawadzki
    Department of Ophthalmology and Vision Science, Vision Science and Advanced Retinal Imaging Laboratory, University of California Davis, Sacramento 95817, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1373-83. 2007
    Adaptive optics-optical coherence tomography (AO-OCT) permits improved imaging of microscopic retinal structures by combining the high lateral resolution of AO with the high axial resolution of OCT, resulting in the narrowest three-..
  65. ncbi Measurement of the thickness of the fibrous cap by optical coherence tomography
    Teruyoshi Kume
    Department of Cardiology, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Am Heart J 152:755.e1-4. 2006
    ..The purpose of this study was to investigate the feasibility of using optical coherence tomography (OCT) to measure the thickness of the fibrous cap within lipid-rich plaque.
  66. doi Reproducibility of retinal thickness measurements on normal and pathologic eyes by different optical coherence tomography instruments
    Andrea Giani
    Retina Service, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Am J Ophthalmol 150:815-24. 2010
    To compare retinal thickness measurements produced by different time-domain and spectral-domain optical coherence tomography (TD-OCT and SD-OCT) devices when imaging normal and pathologic eyes.
  67. pmc Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography
    Vivek J Srinivasan
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Invest Ophthalmol Vis Sci 49:1571-9. 2008
    ..To visualize, quantitatively assess, and interpret outer retinal morphology by using high-speed, ultrahigh-resolution (UHR) OCT...
  68. ncbi Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging
    Teresa C Chen
    Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
    Arch Ophthalmol 123:1715-20. 2005
    To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution.
  69. pmc Mapping of macular substructures with optical coherence tomography for glaucoma diagnosis
    Ou Tan
    Doheny Eye Institute, University of Southern California, Los Angeles, California 90033, USA
    Ophthalmology 115:949-56. 2008
    To use optical coherence tomography (OCT) to identify the specific retinal layers and macular regions damaged in glaucoma.
  70. pmc Clinical and research applications of anterior segment optical coherence tomography - a review
    Jose Luiz Branco Ramos
    Center for Ophthalmic Optics and Lasers, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA
    Clin Experiment Ophthalmol 37:81-9. 2009
    b>Optical coherence tomography (OCT) is being employed more and more often to image pathologies and surgical anatomy within the anterior segment, specifically in anterior chamber biometry, corneal pachymetric mapping, angle evaluation and ..
  71. doi Spectral-domain optical coherence tomography: a comparison of modern high-resolution retinal imaging systems
    Daniel F Kiernan
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA
    Am J Ophthalmol 149:18-31. 2010
    To provide a review of commercially available spectral-domain optical coherence tomography (SD OCT) systems in clinical ophthalmology.
  72. pmc Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema
    David J Browning
    Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
    Ophthalmology 114:525-36. 2007
    To compare optical coherence tomography (OCT)-measured retinal thickness and visual acuity in eyes with diabetic macular edema (DME) both before and after macular laser photocoagulation.
  73. doi Macular thickness measurements in healthy eyes using six different optical coherence tomography instruments
    Ute E K Wolf-Schnurrbusch
    Universitätsklinik für Augenheilkunde, Bern Photographic Reading Center, Inselspital, University of Bern, Bern, Switzerland
    Invest Ophthalmol Vis Sci 50:3432-7. 2009
    ..To compare central retinal thickness (CRT) measurements in healthy eyes by different commercially available OCT instruments and to compare the intersession reproducibility of such measurements...
  74. pmc Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography
    Ou Tan
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Ophthalmology 116:2305-14.e1-2. 2009
    To map ganglion cell complex (GCC) thickness with high-speed Fourier-domain optical coherence tomography (FD-OCT) and compute novel macular parameters for glaucoma diagnosis.
  75. doi Three-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography
    Hideki Koizumi
    Vitreous Retina Macula Consultants of New York, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA
    Am J Ophthalmol 145:509-517. 2008
    ..To delineate the 3-dimensional (3-D) relationship in vitreomacular traction (VMT) and idiopathic epiretinal membrane (ERM)...
  76. doi Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study
    Christopher Kai Shun Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Ophthalmology 116:1257-63, 1263.e1-2. 2009
    ..glaucoma detection, and strength of the structure-function association obtained with a spectral-domain optical coherence tomography (OCT) device (Cirrus HD-OCT; Carl Zeiss Meditec, Inc...
  77. pmc Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging
    Suhail Alam
    Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, California 95817, USA
    Ophthalmology 113:1425-31. 2006
    To introduce and examine the utility of a retinal imaging technique using high-speed optical coherence tomography (OCT) for creating a more complete retinal structural map to aid in the evaluation of patients with macular pathology.
  78. ncbi Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography
    Mark C Pierce
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Burns 30:511-7. 2004
    ..Polarization-sensitive optical coherence tomography (PS-OCT) imaging was used to quantify collagen birefringence in normal human skin, and in skin excised ..
  79. doi Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis
    Axel Petzold
    UCL Institute of Neurology National Hospital for Neurology and Neurosurgery, Department of Neuroimmunology, Queen Square, London, UK
    Lancet Neurol 9:921-32. 2010
    b>Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL)...
  80. pmc Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components
    B Hyle Park
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Opt Lett 29:2512-4. 2004
    We present an analysis for polarization-sensitive optical coherence tomography that facilitates the unrestricted use of fiber and fiber-optic components throughout an interferometer and yields sample birefringence, diattenuation, and ..
  81. ncbi Optical coherence tomography for ultrahigh resolution in vivo imaging
    James G Fujimoto
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 21:1361-7. 2003
    b>Optical coherence tomography (OCT) is an emerging biomedical optical imaging technique that performs high-resolution, cross-sectional tomographic imaging of microstructure in biological systems...
  82. doi Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography
    Yasushi Ikuno
    Department of Ophthalmology, Osaka University Medical School, Osaka Japan
    Invest Ophthalmol Vis Sci 50:3876-80. 2009
    ..Morphologic changes in the retina and choroid are closely related with high myopia-related diseases. This study was conducted to evaluate the morphologic characteristics of normal highly myopic eyes...
  83. pmc Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography
    Varsha Manjunath
    New England Eye Center, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
    Am J Ophthalmol 150:325-329.e1. 2010
    To examine choroidal thickness and area in healthy eyes using spectral-domain optical coherence tomography (SD-OCT).
  84. pmc Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique
    Jeff Fingler
    California Institute of Technology, Pasadena, California 91125, USA
    Opt Express 17:22190-200. 2009
    Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina...
  85. ncbi Bidirectional Doppler Fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels
    René M Werkmeister
    Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria
    Opt Lett 33:2967-9. 2008
    We describe a bidirectional color Doppler Fourier-domain optical coherence tomography system capable of measuring absolute velocities of moving scatterers by illuminating the sample with two linearly and orthogonally polarized beams, ..
  86. ncbi Reproducibility of quantitative optical coherence tomography for stent analysis
    Nieves Gonzalo
    Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    EuroIntervention 5:224-32. 2009
    To assess the inter- and intra- observer reproducibility for strut count, strut apposition and strut tissue coverage measurements with optical coherence tomography (OCT).
  87. doi Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: evidence in optical coherence tomography
    Yan Lu
    Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China
    Neurosci Lett 480:69-72. 2010
    ..The aim of the current study was to determine the thickness changes of retina nerve fibers with optical coherence tomography (OCT) in AD patients...
  88. ncbi A longitudinal study of LASIK flap and stromal thickness with high-speed optical coherence tomography
    Yan Li
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Ophthalmology 114:1124-32. 2007
    To assess corneal anatomic changes after LASIK with a high-speed corneal and anterior segment optical coherence tomography (CAS-OCT) system.
  89. doi Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis
    Bryn M Burkholder
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Arch Neurol 66:1366-72. 2009
    ..Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons)...
  90. doi Optical coherence tomography assessment of in vivo vascular response after implantation of overlapping bare-metal and drug-eluting stents
    Giulio Guagliumi
    Division of Cardiology, Cardiovascular Department, Ospedali Riuniti di Bergamo, Bergamo, Italy
    JACC Cardiovasc Interv 3:531-9. 2010
    We designed a randomized trial exploiting optical coherence tomography (OCT) to assess coverage and apposition of overlapping bare-metal stents (BMS) and drug-eluting stents (DES) in human coronary arteries.
  91. ncbi Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography
    Daisuke Matsumoto
    Department of Internal Medicine, Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    Eur Heart J 28:961-7. 2007
    ..However, optical coherence tomography (OCT) with excellent resolution may be able to detect thinner neointima.
  92. doi Generalized Jones matrix optical coherence tomography: performance and local birefringence imaging
    Shuichi Makita
    Computational Optics Group in University of Tsukuba, Tsukuba, Ibaraki, Japan
    Opt Express 18:854-76. 2010
    ..including local birefringence imaging of biological tissues is described by generalized Jones-matrix optical coherence tomography. The polarization properties of a local tissue can be obtained from two Jones matrices that are ..
  93. ncbi Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography
    Ziqiang Wu
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California 90033, USA
    Ophthalmology 114:1505-12. 2007
    To identify factors associated with variability in retinal nerve fiber layer (RNFL) thickness measurements obtained by optical coherence tomography (OCT).
  94. doi Time domain and spectral domain optical coherence tomography in multiple sclerosis: a comparative cross-sectional study
    Markus Bock
    NeuroCure Clinical Research Center, Charite Universitatsmedizin Berlin, Berlin, Germany, Cecilie Vogt Clinic, Charite Universitatsmedizin Berlin, Berlin, Germany
    Mult Scler 16:893-6. 2010
    Conventional time domain optical coherence tomography has been established for the in vivo assessment of retinal axonal loss in multiple sclerosis...
  95. ncbi Optical coherence tomography and disease subtype in multiple sclerosis
    M Pulicken
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Neurology 69:2085-92. 2007
    ..To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON)...
  96. doi Utility of bleb imaging with anterior segment optical coherence tomography in clinical decision-making after trabeculectomy
    Mandeep Singh
    Department of Ophthalmology, National University Hospital, Singapore 119074
    J Glaucoma 18:492-5. 2009
    To determine if imaging of blebs with anterior segment optical coherence tomography (ASOCT) affects clinical decision-making with regard to laser suture lysis (LSL) after trabeculectomy.
  97. pmc Automated segmentation of neural canal opening and optic cup in 3D spectral optical coherence tomography volumes of the optic nerve head
    Zhihong Hu
    Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa 52242, USA
    Invest Ophthalmol Vis Sci 51:5708-17. 2010
    ..at the level of the retinal pigment epithelium (RPE)/Bruch's membrane (BM) complex in spectral-domain optical coherence tomography (SD-OCT) volumes...
  98. doi Accuracy of RTVue optical coherence tomography, Pentacam, and ultrasonic pachymetry for the measurement of central corneal thickness
    Sang Min Nam
    Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea
    Ophthalmology 117:2096-103. 2010
    ..in measuring central corneal thickness (CCT) using the following technologies: RTVue Fourier-domain optical coherence tomography (Optovue, Inc., Fremont, CA), Pentacam (Oculus, Inc...
  99. pmc Optical coherence tomography: a window into the mechanisms of multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Nat Clin Pract Neurol 4:664-75. 2008
    ..b>Optical coherence tomography (OCT) can provide high-resolution reconstructions of retinal anatomy in a rapid and reproducible ..
  100. pmc High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography
    Vivek J Srinivasan
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 113:2054.e1-14. 2006
    To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies.
  101. pmc Assessment of artifacts and reproducibility across spectral- and time-domain optical coherence tomography devices
    Joseph Ho
    New England Eye Center, Tufts Medical Center, Boston, MA 02111, USA
    Ophthalmology 116:1960-70. 2009
    To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier ..

Research Grants75

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..The evaluations may include the following examinations and tests: -Eye examination with dilation, optical coherence tomography and photography: The examination measures visual acuity, thickness of your retina (the back of the eye) ..
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..The evaluations may include the following examinations and tests: -Eye examination with dilation, optical coherence tomography and photography: The examination measures visual acuity, thickness of your retina (the back of the eye) ..
  3. Prolonged Inhibition of Pathologic Neovascularization by Catalytic Antioxidants
    JAMES FRANCIS MCGINNIS; Fiscal Year: 2013
    ..Fundoscopy, electroretinography and optical coherence tomography will be used for longitudinal studies on the same animal to evaluate neovascularization, retinal ..
  4. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..b>Optical Coherence Tomography (OCT) is an imaging modality that utilizes light to produce high-resolution images of living tissues ..
  5. Role of the kallikrein-kinin system in diabetic retinopathy
    Edward P Feener; Fiscal Year: 2012
    ..we showed that in the presence of diabetes, CA-I caused intraretinal thickening, measured by 3D optical coherence tomography (OCT), at this time point...
  6. Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT
    Jun Zhang; Fiscal Year: 2013
    ..proposes development and testing of an innovative high speed long range endoscopic Fourier domain optical coherence tomography (FDOCT) system capable of non-invasive real time acquisition of quantitative anatomic information such ..
  7. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..Optical fibers embedded within the scaffold will deliver laser light for optical coherence tomography and to excite the fluorescent probes...
  8. Real-Time Optical Diagnosis of Inflammatory Bowel Disease using SFDI
    Sylvain Gioux; Fiscal Year: 2013
    ..Although other optical techniques such as optical coherence tomography (OCT), scattering spectroscopy, and absorption spectroscopy have already been applied to the ..
  9. EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSIS
    Devendra K Agrawal; Fiscal Year: 2013
    ..Epicardial fat thickness will be measured by cardiac CT. Angiogram and Optical Coherence Tomography will be done to assess cardiac function and quantify in-segment minimal luminal diameter and intimal ..
  10. Multimodal Retinal Functional Imaging for Diabetic Retinopathy
    Hao F Zhang; Fiscal Year: 2013
    ..by developing multimodal technologies based on functional photoacoustic ophthalmoscopy (PAOM), optical coherence tomography (OCT)/optical Doppler tomography (ODT)...
  11. Role in Myopia Development of Retinal Pigment Epithelium - A New Therapeutic Targ
    Yan Zhang; Fiscal Year: 2013
    ..will use advanced technologies, including high frequency A-scan ultrasonography, spectral domain optical coherence tomography (SD-OCT) and electroretinography (ERG)...
  12. Optic Nerve Aging and Glaucoma
    Thasarat Vajaranant; Fiscal Year: 2013
    ..aimed at comparing measures of optic nerve aging, as indexed by thinning of the retinal nerve fiber by optical coherence tomography and decreased light sensitivity by visual field testing in women who underwent early oophorectomy and ..
  13. OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHY
    James G Fujimoto; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Optical coherence tomography (OCT) is an emerging imaging technology which performs high resolution, cross-sectional and three-dimensional (3D) imaging of tissue morphology in situ and in real time...
  14. QUANTITATIVE ANALYSIS OF AGING RETINA
    Christine A Curcio; Fiscal Year: 2012
    ..We propose translational research directed toward informing the clinical use of spectral domain optical coherence tomography (SD-OCT), which provides cross-sectional views of all chorioretinal layers, and fundus reflectance and ..
  15. Gene therapy in the cornea
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2012
    ..AAV therapy approaches, established protocols and techniques, including slit-lamp, stereomicroscope and optical coherence tomography, immunohistochemistry, immunoblotting, quantitative PCR, southern blot, transmission electron and ..
  16. African and European Descent, Ocular Blood Flow and Glaucoma Progression
    Alon Harris; Fiscal Year: 2013
    ..medical history, visual field testing (using standard automated perimetry), Fourier domain Doppler optical coherence tomography (FD-OCT) with total retinal blood flow assessment, Stratus optical coherence tomography (OCT) ..
  17. Chinese American Eye Study
    Rohit Varma; Fiscal Year: 2013
    ..pressure, hemoglobin A1c, blood glucose, and serum C-reactive protein;additional tests will include optical coherence tomography of the anterior chamber angle, ultrasonic measurement of the anterior chamber depth and lens thickness, ..
  18. Imaging retinal astrocytes, ganglion cells and axonal transport in vivo
    Brad Fortune; Fiscal Year: 2012
    ..measures of retinal function (electroretinography, ERG) and retinal structure (spectral domain optical coherence tomography, SDOCT), so as to assess potential for use in primate experimental models...
  19. Partnership for Primary Care Imaging
    Stephen A Boppart; Fiscal Year: 2013
    ..This Partnership will develop a new Primary Care Imaging system integrating optical coherence tomography (OCT) imaging with these instruments in a handheld scanner and portable system to advance the ..
  20. Dual Modality System for Imaging Colon Cancer in Mice
    Jennifer Kehlet Barton; Fiscal Year: 2013
    ..Our current endoscopes contain optical coherence tomography and laser induced fluorescence to enable non-destructive, high resolution and high sensitivity imaging ..
  21. Integrated imaging of the form and function of the beating embryonic heart
    ANDREW MARTIN ROLLINS; Fiscal Year: 2013
    ..In the previous funding period, we developed and demonstrated 4-D optical coherence tomography (OCT) technology as a powerful tool to image contraction dynamics and hemodynamics in the early looping ..
  22. VITAMIN D AND IMMUNOMODULATION IN CORONARY ARTERY DISEASE
    Devendra K Agrawal; Fiscal Year: 2013
    ..be followed over a period of six months following coronary intervention with left ventriculogram and optical coherence tomography to assess cardiac function and quantify in-segment minimal luminal diameter, diameter stenosis, late ..
  23. Aspheric SDOCT Imaging System for Dry Eye and Cornea Diagnostics
    ERIC L BUCKLAND; Fiscal Year: 2012
    ..Yet with the prevalence of these outer anterior disease states, the capabilities of spectral domain optical coherence tomography have yet to define a role...
  24. Office based real-time high speed 3D-OCT system for diagnosis of early laryngeal
    TIRUNELVELI RAMALINGAM; Fiscal Year: 2013
    ..and diagnosis of early laryngeal cancer using light based fiber optic imaging technology known as optical Coherence tomography (OCT), which produces a cross- sectional images at near histopathological resolution(Fujimoto et...
  25. Multicenter Cartilage Repair Preclinical Trial in Horses
    Constance R Chu; Fiscal Year: 2010
    ..be assessed with arthroscopy, as well as novel nondestructive imaging technologies such as arthroscopic optical coherence tomography (OCT) and high resolution quantitative MRI at 3T and 7T...
  26. Inhibition of Reflux-Induced Esophageal Adenocarcinoma by Proanthocyanidins
    Laura A Kresty; Fiscal Year: 2013
    ..Aim 3 will evaluate the use of a novel imaging technology, parallel frequency-domain optical coherence tomography (FDOCT), to detect early changes in nuclear morphology or sub-cellular structures linked with the ..
  27. Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
    Scott E Fraser; Fiscal Year: 2010
    ..b>Optical coherence tomography (OCT) and its faster variation called spectral domain OCT (SDOCT) are interferometric imaging ..
  28. STUDIES IN GLAUCOMATOUS OPTIC NERVE DAMAGE
    John C Morrison; Fiscal Year: 2013
    ..These will be guided by assessment of retina and ONH perfusion with Doppler-Optical Coherence Tomography, adapted for rat eyes by Dr. Ruikang Wang at the University of Washington...
  29. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2011
    ..b>Optical coherence tomography (OCT) has become an emerging imaging modality with high depth resolution...
  30. Parallel en-face optical coherence microscopy with adaptive focus
    Guoqiang Li; Fiscal Year: 2012
    ..b>Optical coherence tomography (OCT) has become an emerging imaging modality with high depth resolution...
  31. Ossicle vibration measurements in conductive hearing loss
    Steven L Jacques; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The proposal develops a hand-held otoscope that uses optical coherence tomography (OCT) to image the tympanic membrane and ossicles behind an intact tympanic membrane...
  32. Wavefront Corrected Multimodal Optical Coherence and Two-Photon Microscopy for Ra
    Yuankai Kenny Tao; Fiscal Year: 2012
    ..b>Optical coherence tomography (OCT) is a method of utilizing low-coherence interferometry to detect the scattering properties of ..
  33. High Performance Multimodal Adaptive Optics Retinal Imaging
    R Daniel Ferguson; Fiscal Year: 2011
    ..that combines AO- corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical prototype platform...
  34. Detection of Glaucoma Progression with Macular OCT Imaging
    Kouros Nouri-Mahdavi; Fiscal Year: 2013
    ..for an academic glaucoma specialist with a serious interest in the role of imaging in glaucoma using optical coherence tomography (OCT)...
  35. Quantitative optical imaging of cilia-driven fluid flow
    MICHAEL ANDREW CHOMA; Fiscal Year: 2013
    ..Therefore, new mechanisms of disease need to be discovered. Optical imaging (e.g. optical coherence tomography [OCT]) will enable these discoveries since traditional imaging (e.g...
  36. Magnetomotive optical coherence tomography for molecular imaging of the eye
    Jianhua Wang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Spectral-domain magnetomotive optical coherence tomography for in vivo molecular imaging of the eye Molecular in vivo imaging allows for diagnostic analysis, target screening, and therapeutic ..
  37. RETINAL GANGLION CELL PLASTICITY IN GLAUCOMA
    Vittorio Porciatti; Fiscal Year: 2013
    ..We will also use state-of-the-art optical coherence tomography (OCT) to serially monitor thickness of inner retinal layers, as well as retinal immunohistochemistry at ..
  38. Prasugrel for prevention of early saphenous vein graft thrombosis
    Emmanouil Brilakis; Fiscal Year: 2013
    ..hospitalization will result in lower prevalence of thrombus formation in a target SVG, as assessed by optical coherence tomography performed 12 months post surgery compared to placebo, with similar incidence of major bleeding...
  39. Effect of Hyperglycemia on Embryonic Heart Development
    Devon Scott; Fiscal Year: 2012
    ..b>Optical coherence tomography measurements demonstrated a change in the structure of the outflow tracts in response to hyperglycemia, ..
  40. Photoreceptor Integrity Software
    Timothy J Holmes; Fiscal Year: 2012
    ..involves the study and development of algorithms and software that produce images and measurements from optical coherence tomography in and near the photoreceptor layer - starting most notably with the PIL that is traditionally thought ..
  41. 3-D optical imaging of the in vivo organ of Corti motion at a sub-nanometer scale
    Alfred L Nuttall; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Low optical coherence tomography (OCT) has been used to image biological tissue and is the theoretical basis of microscopes that are commercially available to image the lens and cellular structures of ..
  42. Noninvasive Visualization and Analysis of Organ Systems using OCT and Digital Fun
    Steven J Pittler; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): We propose the acquisition of Bioptigen, Inc. 840 nm SDOCT Optical Coherence Tomography (OCT) bundled with Phoenix Research Laboratories, Inc...
  43. Zebrafish Model of Human Corneal Development and Disease
    Martin Heur; Fiscal Year: 2013
    ..The central corneal thickness will be measured using optical coherence tomography (OCT) and corneal endothelial cell density will be determined using specular microscopy...
  44. Detection of plaque based macrophages with light
    MARC DAVID FELDMAN; Fiscal Year: 2013
    ..b>Optical Coherence Tomography (OCT) has already been demonstrated to accurately image thin fibrous caps and large lipid cores...
  45. Volumetric imaging of blood perfusion and tissue morphology in the cochlea
    Ruikang Wang; Fiscal Year: 2013
    ..instrument is based on a novel optical imaging modality, 3D optical microangiography (OMAG) and optical coherence tomography (OCT) that we have recently developed...
  46. High-resolution imaging of the normal and diseased retina
    Jason Porter; Fiscal Year: 2013
    ..automated perimetry and electroretinography) and retinal nerve fiber layer (RNFL) thickness (using optical coherence tomography) at corresponding time-points to test the hypothesis that laminar pore changes precede axonal and ..
  47. Advanced Imaging for Glaucoma
    David Huang; Fiscal Year: 2012
    ..net) is to improve early detection and long-term monitoring of glaucoma by advancing the technology of optical coherence tomography (OCT), which is uniquely capable of imaging eye structures affected by glaucoma with micrometer ..
  48. Measures of Human Receptor and Post Receptor Activity
    Donald C Hood; Fiscal Year: 2013
    ..on a new noninvasive technique for measuring the structure (anatomy) of the retina, frequency domain optical coherence tomography (fdOCT)...
  49. Regulation of vascular leakage in age related macular degeneration
    MEREDITH GREGORY-KSANDER; Fiscal Year: 2013
    ..Spectral domain optical coherence tomography (SD-OCT) and Isolectin-B staining demonstrated no difference in the size of the neovascular lesion ..
  50. RECOVERY OF OPTICAL ABSORPTION COEFFICIENT IN QUANTITATIVE PHOTOACOUSTIC IMAGING
    Lihong Wang; Fiscal Year: 2011
    ..PAI is also free of speckle artifacts, which exist in optical coherence tomography and ultrasonography...
  51. Therapeutic Effects of Cataract Removal in Alzheimer's Disease
    GROVER CLEVELAND GILMORE; Fiscal Year: 2013
    ..2. To assess the thickness of the retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in large samples of AD patients classified with mild or moderate dementia to determine if the ..
  52. AGE-RELATED CHANGES IN RENAL MORPHOLOGY AND FUNCTION IN CHRONIC KIDNEY DISEASE
    Yu Chen; Fiscal Year: 2013
    ..We hypothesize that a multi-modal optical imaging platform combining optical coherence tomography (OCT) and fluorescence confocal microscopy (FCM) can: 1) provide quantitative measurements of ..
  53. Novel Determination of Microbicide PK in Women's Reproductive Health
    DAVID FRANK KATZ; Fiscal Year: 2013
    ..thickness distribution throughout the vagina - using customized, co-registered spectral domain optical coherence tomography, SD-OCT...
  54. TRABECULAR MESHWORK PROTEINS IN GLAUCOMA
    Sanjoy K Bhattacharya; Fiscal Year: 2013
    ..control DBA/2J-Gpnmb+/SjJ mice using newly developed reagent-based spectral (SD) and magnetomotive (MM) optical coherence tomography (OCT)...
  55. Ophthalmic Imaging Using Adaptive Optics and OCT
    John S Werner; Fiscal Year: 2012
    ..to instrumentation that combines adaptive optics (AO), providing high lateral resolution, with optical coherence tomography (OCT), providing high axial resolution...
  56. MECHANICS OF EARLY BRAIN AND EYE DEVELOPMENT
    Larry A Taber; Fiscal Year: 2013
    ..The experiments, to be conducted on chick and mouse embryos, will employ high-resolution optical coherence tomography (OCT) and fluorescence imaging to measure changes in global and local geometry (e.g...
  57. Ear Canal Optical Coherence Tomography System
    PAUL SHNITSER; Fiscal Year: 2013
    ..As a result, less hearing loss effects will occur among American workers, which will have a significant impact on their quality of life. ..
  58. IOP-Related Force and Failure in the Optic Nerve Head
    Claude F Burgoyne; Fiscal Year: 2013
    ..and susceptibility of individual eyes can be predicted from the results of in viv spectral domain optical coherence tomography (SDOCT) ONH compliance testing, post-mortem 3D reconstruction of the ONH connective tissues and stress/..
  59. Development of visual and neurologic outcome measures in pediatric MS
    AMY TARA WALDMAN; Fiscal Year: 2013
    ..measured by structural non-invasive imaging of the retinal nerve fiber layer [RNFL] and macula using optical coherence tomography [OCT])...
  60. Nanoparticles as OCT Contrast Agents
    Gadi Wollstein; Fiscal Year: 2010
    b>Optical coherence tomography (OCT) provides real-time, objective, in-vivo, high resolution optical cross- sections of the retina and optic nerve...
  61. Oral Cancer Detection Methods in a Community Setting
    Taru Kinnunen; Fiscal Year: 2010
    ..brush biopsy, chemiluminescence with application of tolonium chloride, tissue fluorescence, and optical coherence tomography. Subjects with positive signs for oral precancer or cancer will be followed up via biopsy;histological ..
  62. Linking Biological, Optical, and Mechanical Properties in the Airway Mucosa
    STEVEN CARL GEORGE; Fiscal Year: 2012
    ..non-traditional minimally-invasive optical techniques (multiphoton laser scanning microscopy and optical coherence tomography) to assess bulk and microscopic changes in the matrix, and an in vivo model of tracheal epithelial ..
  63. Combined raman spectroscopy-optical tomagraphy for complete diagnosis of skin can
    Anita Mahadevan Jansen; Fiscal Year: 2009
    ..In this proposal we present a method that combines Optical Coherence Tomography (OCT), an imaging technique that visualizes tissue microstructure, with Raman spectroscopy, a ..
  64. Miniature, rapid, and 3-dimensional OCT scanner for dental imaging
    GUANGHAI JIN; Fiscal Year: 2009
    Agiltron proposes an innovative dental OCT (optical coherence tomography) miniature probe with a unique and high speed 2D MEMS scanner...
  65. Functional brain imaging by laser-induced PAT
    Lihong Wang; Fiscal Year: 2007
    ..The proposed technology does not depend on ballistic/quasi-ballistic or backscattered light as optical coherence tomography (OCT) does...
  66. Northeastern Ohio Animal Imaging Resource Center- NOAIRC
    Jeffrey Duerk; Fiscal Year: 2006
    ..g., quantum dots). We will also create small animal optical coherence tomography with color Doppler and microscopic OCT to promote in vivo spectroscopic methods and high spatial and ..
  67. Optical Coherence Tomography Based Freeze Drying Microscopy
    Mircea Mujat; Fiscal Year: 2010
    ..During the Phase I program PSI will demonstrate the application of Optical Coherence Tomography (OCT) for imaging the 3D structure of product formulations freeze dried in standard product vials...
  68. Noninvasive Diagnosis of Early Bladder Cancers with Optical Coherence Tomography
    Yingtian Pan; Fiscal Year: 2007
    This research proposes to apply our newly developed cystoscopic optical coherence tomography (COCT) to substantially enhance the image resolution and sensitivity/specificity of current endoscopic procedures in the diagnosis and staging of ..
  69. Amniotic Membrane Patch Graft to Cover Glaucoma Drainage Tube
    HOSAM EL SHEHA; Fiscal Year: 2009
    ..that AG- G can be used to cover the GDD tube during the primary implantation, and that anterior segment optical coherence tomography (OCT) can be used to monitor host cell interaction with the transplanted AG-G...
  70. Harmonically detected swept source OCT
    Kristen A Peterson; Fiscal Year: 2011
    ..The approach uses a patent pending harmonic detection method combined with swept source optical coherence tomography for subsurface imaging of the interior walls of arteries...
  71. Combined OCT/FLIM Biochemical and Anatomical Imaging for Early Cancer Diagnosis
    Javier Jo; Fiscal Year: 2009
    ..morphological and biochemical information by combining two well developed optical imaging techniques, optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIM)...
  72. NonInvasive Optical Imaging of Vocal Cord Microstructure
    Brian Wong; Fiscal Year: 2004
    ..a non-contact imaging device to provide high-resolution cross-sectional images of the TVC using Optical Coherence Tomography (OCT)...
  73. Autoregulation and Systemic Blood Pressure: A New View of Normal Tension Glaucoma
    Mary Charlson; Fiscal Year: 2009
    ..over the course of 48 hours and will have scanning laser tomography (Heidelberg retinal tomography), optical coherence tomography, and stereo photographs of the optic disc...
  74. Harmonically detected swept source OCT
    Kristen Peterson; Fiscal Year: 2007
    ..The approach uses a novel harmonic detection method combined with swept source optical coherence tomography, for subsurface imaging of the interior walls of arteries...
  75. Functional Optical Coherence Tomography for Imaging of Cortical Hemodynamics
    VIVEK JAY SRINIVASAN; Fiscal Year: 2010
    b>Optical coherence tomography (OCT) is an optical imaging modality that can perform micron scale, tomographic cross-sectional imaging of microstructure in biological tissues in situ and in real time...