optical tomography

Summary

Summary: Projection of near-IR light (INFRARED RAYS), in the 700-1000 nm region, across an object in parallel beams to an array of sensitive photodetectors. This is repeated at various angles and a mathematical reconstruction provides three dimensional MEDICAL IMAGING of tissues. Based on the relative transparency of tissues to this spectra, it has been used to monitor local oxygenation, brain and joints.

Top Publications

  1. ncbi Image analysis methods for diffuse optical tomography
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:33001. 2006
  2. pmc Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Neoplasia 10:1028-40. 2008
  3. pmc Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography
    Benjamin W Zeff
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:12169-74. 2007
  4. ncbi Noncontact fluorescence diffuse optical tomography of heterogeneous media
    L Herve
    CEA LETI, MINATEC, Grenoble F 38054, France
    Appl Opt 46:4896-906. 2007
  5. pmc Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis
    Quing Zhu
    Bioengineering Program, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Radiology 256:367-78. 2010
  6. ncbi Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints
    Zhen Yuan
    University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611 6131, USA
    J Biomed Opt 12:034001. 2007
  7. ncbi Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI
    Regine Choe
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104 6396, USA
    Med Phys 32:1128-39. 2005
  8. ncbi A soft deformable tissue-equivalent phantom for diffuse optical tomography
    Jeremy C Hebden
    Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK
    Phys Med Biol 51:5581-90. 2006
  9. ncbi Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging
    Abhijit J Chaudhari
    Signal and Image Processing Institute, Department of Electrical Engineering Systems, University of Southern California, Los Angeles, 90089, USA
    Phys Med Biol 50:5421-41. 2005
  10. ncbi Real-time diffuse optical tomography based on structured illumination
    Samuel Bélanger
    Ecole Polytechnique de Montreal, Département de génie électrique, Montreal, Quebec, Canada
    J Biomed Opt 15:016006. 2010

Detail Information

Publications245 found, 100 shown here

  1. ncbi Image analysis methods for diffuse optical tomography
    Brian W Pogue
    Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA
    J Biomed Opt 11:33001. 2006
    ..Each of these three major areas of image interpretation and analysis are reviewed in the context of medical imaging as well as how they are used to quantify the performance of diffuse optical imaging of tissue...
  2. pmc Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Neoplasia 10:1028-40. 2008
    The purposes of this study were 1) to investigate the feasibility of using optical tomography in the near-infrared (NIR) spectrum combined with ultrasound (US) localization (NIR/US) in monitoring tumor vascular changes and assessing tumor ..
  3. pmc Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography
    Benjamin W Zeff
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:12169-74. 2007
    ..We have developed a high-performance, high-density diffuse optical tomography (DOT) system that overcomes previous limitations and enables superior image quality...
  4. ncbi Noncontact fluorescence diffuse optical tomography of heterogeneous media
    L Herve
    CEA LETI, MINATEC, Grenoble F 38054, France
    Appl Opt 46:4896-906. 2007
    Fluorescence-enhanced diffuse optical tomography is expected to be useful to the collection of functional information from small animal models...
  5. pmc Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis
    Quing Zhu
    Bioengineering Program, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Radiology 256:367-78. 2010
    To investigate the potential role of optical tomography in the near-infrared (NIR) spectrum with ultrasonographic (US) localization as a means of differentiating early-stage cancers from benign lesions of the breast.
  6. ncbi Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints
    Zhen Yuan
    University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611 6131, USA
    J Biomed Opt 12:034001. 2007
    This work presents a pilot study to show the potential of an emerging imaging modality, near-infrared diffuse optical tomography (DOT), for the diagnosis of osteoarthritis (OA)...
  7. ncbi Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI
    Regine Choe
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104 6396, USA
    Med Phys 32:1128-39. 2005
    We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy...
  8. ncbi A soft deformable tissue-equivalent phantom for diffuse optical tomography
    Jeremy C Hebden
    Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK
    Phys Med Biol 51:5581-90. 2006
    A recipe is presented for the manufacture of highly compressible phantoms for diffuse optical tomography. The recipe is based on polyvinyl alcohol (PVA) slime, a viscoelastic fluid which readily deforms under moderate pressure...
  9. ncbi Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging
    Abhijit J Chaudhari
    Signal and Image Processing Institute, Department of Electrical Engineering Systems, University of Southern California, Los Angeles, 90089, USA
    Phys Med Biol 50:5421-41. 2005
    ..Co-registration of the reconstructed 3D bioluminescent image with magnetic resonance images indicated good anatomical localization of the tumour...
  10. ncbi Real-time diffuse optical tomography based on structured illumination
    Samuel Bélanger
    Ecole Polytechnique de Montreal, Département de génie électrique, Montreal, Quebec, Canada
    J Biomed Opt 15:016006. 2010
    ..The structured illumination method proposed in this work has significant cost advantages over camera systems, as only a single detector is required. This configuration also has the potential to increase frame rate...
  11. ncbi A self-normalized, full time-resolved method for fluorescence diffuse optical tomography
    Feng Gao
    College of Precision Instrument and Optoeletronics Engineering, Tianjin University, Tianjin 300072, China
    Opt Express 16:13104-21. 2008
    A full time-resolved scheme that has been previously applied in diffuse optical tomography is extended to time-domain fluorescence diffuse optical tomography regime, based on a finite-element-finite-time-difference photon diffusion ..
  12. ncbi Improved quantification of small objects in near-infrared diffuse optical tomography
    Subhadra Srinivasan
    Dartmouth College, Thayer School of Engineering, Hanover, NH 03755, USA
    J Biomed Opt 9:1161-71. 2004
    Diffuse optical tomography allows quantification of hemoglobin, oxygen saturation, and water in tissue, and the fidelity in this quantification is dependent on the accuracy of optical properties determined during image reconstruction...
  13. ncbi Spectrally resolved bioluminescence optical tomography
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Opt Lett 31:365-7. 2006
    Spectrally resolved bioluminescence optical tomography is an approach to recover images of luciferase activity within a volume using multiwavelength emission data from internal bioluminescence sources...
  14. ncbi Time-resolved diffuse optical tomography and its application to in vitro and in vivo imaging
    Huijuan Zhao
    Tianjin University, State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin 3000072, China
    J Biomed Opt 12:062107. 2007
    This work reviews our research during the past several years on time-resolved (TR) near-infrared diffuse optical tomography (DOT)...
  15. pmc A novel fluorescent imaging agent for diffuse optical tomography of the breast: first clinical experience in patients
    Stephanie van de Ven
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Imaging Biol 12:343-8. 2010
    This is the first clinical evaluation of a novel fluorescent imaging agent (Omocianine) for breast cancer detection with diffuse optical tomography (DOT).
  16. ncbi Differentiation of cysts from solid tumors in the breast with diffuse optical tomography
    Xuejun Gu
    Department of Physics and Astronomy, Clemson University, Clemson, SC 29634 0978, USA
    Acad Radiol 11:53-60. 2004
    Near-infrared diffuse optical tomography (DOT) is an emerging imaging technology that has the potential to offer enhanced contrast resolution over the existing technologies for detection and diagnosis of breast cancer...
  17. pmc Numerical modelling and image reconstruction in diffuse optical tomography
    Hamid Dehghani
    School of Computer Science, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Philos Trans A Math Phys Eng Sci 367:3073-93. 2009
    The development of diffuse optical tomography as a functional imaging modality has relied largely on the use of model-based image reconstruction...
  18. ncbi Recent advances in diffuse optical imaging
    A P Gibson
    Department of Medical Physics and Bioengineering, University College London, UK
    Phys Med Biol 50:R1-43. 2005
    ..We review recent work on in vivo applications including imaging the breast and brain, and examine future challenges...
  19. pmc Utilizing optical tomography with ultrasound localization to image heterogeneous hemoglobin distribution in large breast cancers
    Quing Zhu
    University of Connecticut, 371 Fairfield Road, U1157, Storrs, CT 06269, USA
    Neoplasia 7:263-70. 2005
    ..By combining ultrasound (US) and near-infrared (NIR) optical imaging, a reliable new technique has emerged for localizing and characterizing tumor angiogenesis within the breast...
  20. ncbi Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging
    Danny K Joseph
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA 02129, USA
    Appl Opt 45:8142-51. 2006
    ..Experimental results showing the application of this instrument for imaging human brain activation are also presented. The observed improvement in spatial resolution is confirmed by functional magnetic resonance imaging...
  21. ncbi Complete-angle projection diffuse optical tomography by use of early photons
    Gordon M Turner
    Laboratory for Bio optics and Molecular Imaging, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 30:409-11. 2005
    ..first, to our knowledge, experimental images of complex-shaped phantoms embedded in diffuse media by use of optical tomography. Imaging is based on a complete-angle projection tomographic technique that utilizes transmitted early ..
  22. ncbi Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system
    Changqing Li
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 6131, USA
    Med Phys 33:627-36. 2006
    We describe a compact diffuse optical tomography system specifically designed for breast imaging...
  23. pmc Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light
    Soren D Konecky
    Laser Microbeam and Medical Program LAMMP, Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road, Irvine, CA 92617, USA
    Opt Express 17:14780-90. 2009
    ..The method provides more accurate quantification of optical absorption and higher resolution than standard diffuse reflectance measurements...
  24. ncbi In vivo mice lung tumor follow-up with fluorescence diffuse optical tomography
    Anne Koenig
    Commissariat a l Energie Atomique, Lab d Electronique de Technologie de l Information, MINATEC, 17 rue des Martyrs, 38054 Grenoble, Cedex 9, France
    J Biomed Opt 13:011008. 2008
    ..As expected, the reconstructed fluorescence increases along with the tumor stage. These results validate the use of our system for biological studies of small animals...
  25. ncbi Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate, part II: experimental demonstration
    Zhen Jiang
    School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, OK 74078, USA
    Opt Express 16:17505-20. 2008
    We demonstrate trans-rectal optical tomography of the prostate using an endo-rectal near-infrared (NIR) applicator integrated with a transrectal ultrasound (TRUS) probe...
  26. ncbi Sagittal laser optical tomography for imaging of rheumatoid finger joints
    Andreas H Hielscher
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Phys Med Biol 49:1147-63. 2004
    ..We have used this system to obtain tomographic images of six proximal interphalangeal finger joints from two patients with rheumatoid arthritis. The optical images were compared to clinical symptoms and ultrasound images...
  27. ncbi Fast tomographic reconstruction strategy for diffuse optical tomography
    Yuhu Zhai
    National High Magnetic Field Laboratory, Tallahassee, FL 32310, USA
    Opt Express 17:5285-97. 2009
    Diffuse Optical Tomography (DOT) has been growing significantly in the past two decades as a promising tool for in-vivo and non-invasive imaging of tissues using near-infrared light...
  28. ncbi Quantitative diffuse optical tomography for small animals using an ultrafast gated image intensifier
    Sachin V Patwardhan
    Washington University School of Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Biomed Opt 13:011009. 2008
    ..an ultrafast gated image intensifier and a pulsed laser source, we have developed a small animal diffuse optical tomography system with multiple synthetic modulation frequencies up to >1 GHz...
  29. pmc Resting-state functional connectivity in the human brain revealed with diffuse optical tomography
    Brian R White
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Neuroimage 47:148-56. 2009
    ..Diffuse optical tomography (DOT) is an emerging functional neuroimaging technique with the advantages, relative to functional magnetic ..
  30. ncbi High-resolution ultrasound-modulated optical tomography in biological tissues
    Sava Sakadzic
    Optical Imaging Laboratory, Department of Biomedical Engineering, 3120 TAMU, Texas A and M University, College Station, Texas 77843 3120, USA
    Opt Lett 29:2770-2. 2004
    We present a novel implementation of high-resolution ultrasound-modulated optical tomography that, based on optical contrast, can image several millimeters deep into soft biological tissues...
  31. ncbi Optical tomography of breast cancer-monitoring response to primary medical therapy
    Louise C Enfield
    Department of Medical Physics and Bioengineering, Malet Place Engineering Building, University College London, Gower Street, London, WC1E 6BT, UK
    Target Oncol 4:219-33. 2009
    ..These findings demonstrate that optical techniques could play a role in the monitoring of changes in angiogenesis, apoptosis and hypoxia due to neoadjuvant chemotherapy...
  32. pmc Optical tomography with ultrasound localization for breast cancer diagnosis and treatment monitoring
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, 371 Fairfield Way, University of Connecticut, Storrs, CT 03269, USA
    Surg Oncol Clin N Am 16:307-21. 2007
    b>Optical tomography with ultrasound (US) localization uses coregistered ultrasound images to guide optical imaging reconstruction...
  33. ncbi Fast image reconstruction in fluorescence optical tomography using data compression
    Timothy J Rudge
    Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK
    Opt Lett 35:763-5. 2010
    We present a method for fast reconstruction in fluorescence optical tomography with very large data sets...
  34. ncbi In vivo continuous-wave optical breast imaging enhanced with Indocyanine Green
    Xavier Intes
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Med Phys 30:1039-47. 2003
    We investigate the uptake of a nontargeted contrast agent by breast tumors using a continuous wave diffuse optical tomography apparatus...
  35. ncbi Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media
    Elizabeth M C Hillman
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 29:1650-2. 2004
    Laminar optical tomography (LOT) is a new technique that combines the advantages of diffuse optical tomography image reconstruction and a microscopy-based setup to allow noncontact imaging with 100-200-microm resolution effective over ..
  36. pmc Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography
    Soren D Konecky
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
    Med Phys 35:446-55. 2008
    ..compare three-dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET)...
  37. ncbi Digital-signal-processor-based dynamic imaging system for optical tomography
    Joseph M Lasker
    Department of Biomedical Engineering, Columbia University, 351 Engineering Terrace MC8904, New York, NY 10027, USA
    Rev Sci Instrum 78:083706. 2007
    In this article, we introduce a dynamic optical tomography system that is, unlike currently available analog instrumentation, based on digital data acquisition and filtering techniques...
  38. ncbi Fluorescence diffuse optical tomography for free-space and multifluorophore studies
    Anne Koenig
    CEA LETI, MINATEC, Grenoble, France
    J Biomed Opt 15:016016. 2010
    We present two major advances in preclinical fluorescence-enhanced diffuse optical tomography (fDOT) system and assess its performance...
  39. ncbi Computational calibration method for optical tomography
    Tanja Tarvainen
    Department of Applied Physics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Appl Opt 44:1879-88. 2005
    We propose a computational calibration method for optical tomography. The model of the calibration scheme is based on the rotation symmetry of source and detector positions in the measurement setup...
  40. ncbi Choice of data types in time resolved fluorescence enhanced diffuse optical tomography
    Jason Riley
    Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Building 9, Bethesda, Maryland 20892, USA
    Med Phys 34:4890-900. 2007
    In this paper we examine possible data types for time resolved fluorescence enhanced diffuse optical tomography (FDOT)...
  41. pmc Three-dimensional fluorescence-enhanced optical tomography using a hand-held probe based imaging system
    Jiajia Ge
    Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, Florida 33174, USA
    Med Phys 35:3354-63. 2008
    ..Herein, a novel hand-held probe based optical imager is developed towards three-dimensional (3-D) optical tomography studies...
  42. ncbi Adaptation and focusing of optode configurations for fluorescence optical tomography by experimental design methods
    Manuel Freiberger
    Graz University of Technology, Institute of Medical Engineering, Graz, Austria
    J Biomed Opt 15:016024. 2010
    ..Examples for the attenuation of fluorophore signals from regions outside the focus are given...
  43. ncbi Hybrid Fourier-real space method for diffuse optical tomography
    Jorge Ripoll
    Institute for Electronic Structure and Laser, Foundation for Research and Technology Hellas, P O Box 1527, Heraklion 71110, Greece
    Opt Lett 35:688-90. 2010
    b>Optical tomography has recently witnessed a substantial increase in the size of the data sets used, mainly owing to the use of CCD cameras...
  44. ncbi Optimal linear inverse solution with multiple priors in diffuse optical tomography
    Ang Li
    Department of Physics Tufts University, Medford, Massachusetts 02155, USA
    Appl Opt 44:1948-56. 2005
    A general framework for incorporating single and multiple priors in diffuse optical tomography is described...
  45. ncbi A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part II. Three-dimensional reconstructions
    Nicolas Ducros
    CEA, LETI, MINATEC, 17 rue des Martyrs, F 38054 Grenoble, France
    Phys Med Biol 54:7107-19. 2009
    This paper addresses the inverse problem of time-resolved (fluorescence) diffuse optical tomography from temporal moments of the measurements. A methodology that enables one to provide fairly comparable reconstructions is presented...
  46. ncbi A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical material
    Nicolas Ducros
    CEA, LETI, MINATEC, 17 rue des Martyrs, F 38054 Grenoble, France
    Phys Med Biol 54:7089-105. 2009
    The problem of fluorescence diffuse optical tomography consists in localizing fluorescent markers from near-infrared light measurements...
  47. ncbi A haemodynamic response function model in spatio-temporal diffuse optical tomography
    Yiheng Zhang
    Department of Radiology, University of Michigan Hospital, 1500 E Medical Center Drive, CGC B2109, Ann Arbor, MI 48109, USA
    Phys Med Biol 50:4625-44. 2005
    Diffuse optical tomography (DOT) is a new and effective technique for functional brain imaging...
  48. ncbi Design and implementation of a multifrequency near-infrared diffuse optical tomography system
    Gultekin Gulsen
    University of California, Tu and Yuen Center for Functional Onco Imaging, Irvine, California 92697, USA
    J Biomed Opt 11:014020. 2006
    The design and implementation of a multifrequency and multispectral diffuse optical tomography system is described. Four wavelengths are utilized: 665, 785, 808, and 830 nm...
  49. ncbi A higher order diffusion model for three-dimensional photon migration and image reconstruction in optical tomography
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Phys Med Biol 54:65-88. 2009
    ..We conclude that the developed higher order diffusion model is able to accurately describe light propagation in biological tissues and to offer improved image reconstruction...
  50. ncbi Significance of tissue anisotropy in optical tomography of the infant brain
    Juha Heiskala
    BioMag Laboratory, Helsinki University Central Hospital, Helsinki, Finland
    Appl Opt 46:1633-40. 2007
    We study the effect of tissue anisotropy in optical tomography of neonates...
  51. ncbi Total light approach of time-domain fluorescence diffuse optical tomography
    Andhi Marjono
    Department of Mechanical Engineering and Intelligent Systems, University of Electro Communications, Chofu, Tokyo, Japan
    Opt Express 16:15268-85. 2008
    In this study, time-domain fluorescence diffuse optical tomography in biological tissue is numerically investigated using a total light approach...
  52. ncbi Linear and nonlinear reconstruction for optical tomography of phantoms with nonscattering regions
    Adam P Gibson
    Department of Medical Physics and Bioengineering, University College London, London WC1E 6JA, United Kingdom
    Appl Opt 44:3925-36. 2005
    ..This study supports the use of linear reconstruction for dynamic imaging but suggests that, in all cases, image quality is likely to improve if the clear regions are modeled correctly...
  53. ncbi Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography
    Phaneendra K Yalavarthy
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 34:2085-98. 2007
    Diffuse optical tomography (DOT) involves estimation of tissue optical properties using noninvasive boundary measurements...
  54. ncbi Gauss-Newton method for image reconstruction in diffuse optical tomography
    Martin Schweiger
    Department of Computer Science, University College London, Gower Street London WC1E 6BT, UK
    Phys Med Biol 50:2365-86. 2005
    ..for solving the inverse problem of parameter reconstruction from boundary data in frequency-domain diffuse optical tomography. To avoid the explicit formation and inversion of the Hessian which is often prohibitively expensive in ..
  55. pmc Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation
    Virna Cortez-Retamozo
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 118:4058-66. 2008
    ..Both fluorescence-mediated tomography and fiberoptic bronchoscopy techniques have the potential to be translated into the clinic...
  56. ncbi Depth sensitivity and image reconstruction analysis of dense imaging arrays for mapping brain function with diffuse optical tomography
    Hamid Dehghani
    School of Computer Science, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Appl Opt 48:D137-43. 2009
    The development of diffuse optical tomography (DOT) instrumentation for neuroimaging of humans is challenging due to the large size and the geometry of the head and the desire to distinguish signals at different depths...
  57. ncbi Tomographic fluorescence mapping of tumor targets
    Xavier Montet
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 65:6330-6. 2005
    ..FMT measurements can be done serially, with short imaging times and within the same live animal. The described method should be valuable for rapidly profiling biological phenomena in vivo...
  58. ncbi Image correction algorithm for functional three-dimensional diffuse optical tomography brain imaging
    Yong Xu
    Department of Pathology, SUNY Downstate Medical Center, New York 11203, USA
    Appl Opt 46:1693-704. 2007
    We outline a computationally efficient image correction algorithm, which we have applied to diffuse optical tomography (DOT) image time series derived from a magnetic resonance imaging (MRI)-based brain model...
  59. ncbi Fluorescence diffuse optical tomography with functional and anatomical a priori information: feasibility study
    Y Lin
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92617, USA
    Phys Med Biol 52:5569-85. 2007
    Fluorescence diffuse optical tomography (FT) is an emerging molecular imaging technique that can spatially resolve both fluorophore concentration and lifetime parameters...
  60. pmc Quantitative evaluation of high-density diffuse optical tomography: in vivo resolution and mapping performance
    Brian R White
    Washington University School of Medicine, Department of Radiology and Department of Physics, St Louis, Missouri 63110, USA
    J Biomed Opt 15:026006. 2010
    ..While recent technical developments such as high-density diffuse optical tomography (HD-DOT) have, in principle, been shown to have superior in silico image quality, the majority of optical ..
  61. ncbi Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography
    Ang Li
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 29:256-8. 2004
    ..We demonstrate this improvement with simulations and a dynamic blood phantom experiment...
  62. ncbi Time-domain optical mammography SoftScan: initial results
    Xavier Intes
    Art, Advanced Research Technologies, Saint Laurent Quebec, Canada
    Acad Radiol 12:934-47. 2005
    ..In this study, the authors report quantitative measurements of these components and the functional contrast between healthy and diseased tissue...
  63. ncbi Image reconstruction in optical tomography in the presence of coupling errors
    Martin Schweiger
    Centre for Medical Image Computing, University College London, London, UK
    Appl Opt 46:2743-56. 2007
    Image reconstruction in optical tomography is a nonlinear and generally ill- posed inverse problem. Noise in the measured surface data can give rise to substantial artifacts in the recovered volume images of optical coefficients...
  64. ncbi Principal component analysis of dynamic fluorescence diffuse optical tomography images
    Xin Liu
    Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China
    Opt Express 18:6300-14. 2010
    Challenges remain in resolving drug distributions within small animals utilizing fluorescence diffuse optical tomography (FDOT)...
  65. ncbi Time-resolved diffuse optical tomography with patterned-light illumination and detection
    Jin Chen
    Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Opt Lett 35:2121-3. 2010
    This investigation explores the feasibility of performing diffuse optical tomography based on time-domain wide-field illumination and detection strategies...
  66. ncbi Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies
    A Godavarty
    Photon Migration Laboratory, Texas A and M University, College Station, TX 77843 3573, USA
    J Biomed Opt 9:488-96. 2004
    ..Diagnostic 3-D fluorescence-enhanced optical tomography is demonstrated using 0...
  67. pmc In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography
    Jia Wang
    Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 37:3715-24. 2010
    ..A NIR tomography system that combines frequency domain (FD) and continuous wave (CW) measurements was used to image normal and malignant breast tissues...
  68. ncbi Transport- and diffusion-based optical tomography in small domains: a comparative study
    Kui Ren
    Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027, USA
    Appl Opt 46:6669-79. 2007
    We compare reconstructions based on the radiative transport and diffusion equations in optical tomography for media of small sizes...
  69. ncbi Focusing optics of a parallel beam CCD optical tomography apparatus for 3D radiation gel dosimetry
    Nikola Krstajic
    Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK
    Phys Med Biol 51:2055-75. 2006
    b>Optical tomography of gel dosimeters is a promising and cost-effective avenue for quality control of radiotherapy treatments such as intensity-modulated radiotherapy (IMRT)...
  70. ncbi Diffuse optical tomography guided quantitative fluorescence molecular tomography
    Yiyong Tan
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Appl Opt 47:2011-6. 2008
    We describe a method that combines fluorescence molecular tomography (FMT) with diffuse optical tomography (DOT), which allows us to study the impact of heterogeneous optical property distribution on FMT, an issue that has not been ..
  71. ncbi In vitro whole-organ imaging: 4D quantification of growing mouse limb buds
    Marit J Boot
    Medical Research Council Human Genetics Unit, Crewe Road South, Edinburgh EH4 2XU, UK
    Nat Methods 5:609-12. 2008
    ..We developed a four-dimensional (4D) imaging technique that can be used to quantitatively image tissue movements and dynamic GFP expression domains in a growing transgenic mouse limb by time-lapse optical projection tomography (OPT)...
  72. ncbi Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals
    Gultekin Gulsen
    Tu and Yuen Center for Functional Onco Imaging, 164 Irvine Hall, University of California, Irvine, California 92697, USA
    Technol Cancer Res Treat 5:351-63. 2006
    ..As a part of this effort, a multi-spectral frequency domain diffuse optical tomography system is integrated with an MRI system...
  73. ncbi 3D level set reconstruction of model and experimental data in Diffuse Optical Tomography
    M Schweiger
    Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK
    Opt Express 18:150-64. 2010
    ..In the case of diffuse optical tomography, level sets can be employed to simultaneously recover inclusions that differ in their absorption or ..
  74. ncbi Fully adaptive FEM based fluorescence optical tomography from time-dependent measurements with area illumination and detection
    Amit Joshi
    Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Med Phys 33:1299-310. 2006
    ..The results demonstrate the first clinically relevant noncontact fluorescence tomography with adaptive finite element methods...
  75. pmc Anatomical atlas-guided diffuse optical tomography of brain activation
    Anna Custo
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroimage 49:561-7. 2010
    We describe a neuroimaging protocol that utilizes an anatomical atlas of the human head to guide diffuse optical tomography of human brain activation...
  76. ncbi Visible and near-infrared laser radiation in a biological tissue. A forward model for medical imaging by optical tomography
    H Trabelsi
    Unité de Rayonnement Thermique, Departement de Physique, Faculte des Sciences de Tunis, 2092 El Manar, Tunisia
    Lasers Med Sci 25:41-53. 2010
    ..In medical imaging by laser techniques, this could be an optical tomography forward model...
  77. ncbi Quality-based registration and reconstruction of optical tomography volumes
    Wolfgang Wein
    Chair for Computer Aided Medical Procedures CAMP Technische Universität München, Germany
    Med Image Comput Comput Assist Interv 10:718-25. 2007
    ..The methods are applied on acquisitions of a mouse brain and mouse embryo to create outstanding three-dimensional reconstructions...
  78. pmc Estimation and statistical bounds for three-dimensional polar shapes in diffuse optical tomography
    Gregory Boverman
    Biomedical Engineering Department, Rensselaer Polytechnic Institute, 7046 Jonsson Engineering Center, Troy, NY 12180, USA
    IEEE Trans Med Imaging 27:752-65. 2008
    Voxel-based reconstructions in diffuse optical tomography (DOT) using a quadratic regularization functional tend to produce very smooth images due to the attenuation of high spatial frequencies...
  79. ncbi Quantitative bioluminescence tomography guided by diffuse optical tomography
    Qizhi Zhang
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Opt Express 16:1481-6. 2008
    ..incorporating prior spatial distribution of optical properties of heterogeneous media obtained from diffuse optical tomography (DOT)...
  80. pmc Implementation of a computationally efficient least-squares algorithm for highly under-determined three-dimensional diffuse optical tomography problems
    Phaneendra K Yalavarthy
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Med Phys 35:1682-97. 2008
    Three-dimensional (3D) diffuse optical tomography is known to be a nonlinear, ill-posed and sometimes under-determined problem, where regularization is added to the minimization to allow convergence to a unique solution...
  81. ncbi Optimal sparse solution for fluorescent diffuse optical tomography: theory and phantom experimental results
    Pouyan Mohajerani
    Department of Electrical and Computer Engineering, Georgia Institute of Technology, Georgia 30332, USA
    Appl Opt 46:1679-85. 2007
    ..a method to accurately localize small fluorescent objects within the tissue using fluorescent diffuse optical tomography (FDOT)...
  82. ncbi Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints
    Zhen Yuan
    University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611 6131, USA
    J Biomed Opt 13:044006. 2008
    We describe a multimodality imaging approach that combines x-ray tomosynthesis with near-infrared diffuse optical tomography (DOT) for high-resolution imaging of osteoarthritis in the finger joints...
  83. pmc Diffuse optical tomography of the breast: initial validation in benign cysts
    Stephanie van de Ven
    Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Imaging Biol 11:64-70. 2009
    The purpose of this study was to validate a newly developed diffuse optical tomography (DOT) system on benign cysts in the breast.
  84. ncbi Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging
    Stephanie M W Y van de Ven
    Department of Radiology, University Medical Center Utrecht, E 01 132, Heidelberglaan 100, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Eur Radiol 19:1108-13. 2009
    This paper presents an evaluation of a prototype diffuse optical tomography (DOT) system...
  85. ncbi Multiplicative optical tomography of cardiac electrical activity
    Marcel Wellner
    Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Phys Med Biol 51:4429-46. 2006
    ..Our approach is nonlinear and differs substantially from standard diffusive optical tomography. It does not require matrix inversion, data regularization or a priori information concerning the original ..
  86. pmc Diffuse optical tomography of pain and tactile stimulation: activation in cortical sensory and emotional systems
    L Becerra
    P A I N Group McLean Hospital, Massachusetts General Hospital, Harvard Medical School, USA
    Neuroimage 41:252-9. 2008
    Using diffuse optical tomography (DOT), we detected activation in the somatosensory cortex and frontal brain areas following tactile (brush) and noxious heat stimulation...
  87. pmc Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269 1157, USA
    Radiology 237:57-66. 2005
    To investigate prospectively the feasibility of using optical tomography with ultrasonographic (US) localization to differentiate malignant from benign breast masses and to compare optical tomography with color Doppler US.
  88. ncbi Diffuse optical tomography with spectral constraints and wavelength optimization
    Alper Corlu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Appl Opt 44:2082-93. 2005
    ..an algorithm that explicitly utilizes the wavelength dependence of tissue optical properties for diffuse optical tomography. We have previously shown that the method gives superior separation of absorption and scattering...
  89. ncbi Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions
    Paola Taroni
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2469-88. 2005
    ..The capacity to assess the density of breast based on the average scattering properties was also tested...
  90. ncbi Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography
    Alper Corlu
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Opt Lett 28:2339-41. 2003
    ..recovery of chromophore concentrations and scattering coefficients in multispectral continuous-wave diffuse optical tomography. These conditions depend strongly on measurement wavelengths...
  91. ncbi Scanning time-domain optical mammography: detection and characterization of breast tumors in vivo
    Herbert Rinneberg
    Division of Medical Physics and Metrological Information Technology, Physikalisch Technische Bundesanstalt, Abbestrasse 2 12, 10587 Berlin, Germany
    Technol Cancer Res Treat 4:483-96. 2005
    ..In addition developments on instrumentation and data analysis are covered and possible improvements of optical mammography are briefly discussed...
  92. ncbi Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information
    Gregory Boverman
    Department of Electrical and Computer Engineering, Northeastern University, 302 Stearns Hall, Boston, MA 02115, USA
    Phys Med Biol 50:3941-56. 2005
    Spectroscopic diffuse optical tomography (DOT) can directly image the concentrations of physiologically significant chromophores in the body...
  93. pmc Dynamic physiological modeling for functional diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 30:88-101. 2006
    Diffuse optical tomography (DOT) is a noninvasive imaging technology that is sensitive to local concentration changes in oxy- and deoxyhemoglobin...
  94. ncbi Parallel programming of gradient-based iterative image reconstruction schemes for optical tomography
    Andreas H Hielscher
    Departments of Biomedical Engineering and Radiology, Columbia University, 500 West 120th Street, MC 8904, New York, NY 10027, USA
    Comput Methods Programs Biomed 73:101-13. 2004
    b>Optical tomography (OT) is a fast developing novel imaging modality that uses near-infrared (NIR) light to obtain cross-sectional views of optical properties inside the human body...
  95. ncbi The effects of internal refractive index variation in near-infrared optical tomography: a finite element modelling approach
    Hamid Dehghani
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Phys Med Biol 48:2713-27. 2003
    ....
  96. ncbi Optical tomography of the neonatal brain
    Jeremy C Hebden
    Department of Medical Physics and Bioengineering, University College London, Gower Street, London, WC1E 6BT, UK
    Eur Radiol 17:2926-33. 2007
    ..b>Optical tomography has so far provided static three-dimensional maps of blood volume and oxygenation as well as dynamic images ..
  97. pmc Optical tomography with ultrasound localization: initial clinical results and technical challenges
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Technol Cancer Res Treat 4:235-44. 2005
    b>Optical tomography with ultrasound localization utilizes co-registered ultrasound lesion structure information to guide optical imaging reconstruction...
  98. ncbi Multispectral diffuse optical tomography with absorption and scattering spectral constraints
    Changqing Li
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 6131, USA
    Appl Opt 46:8229-36. 2007
    ..well as the volume fraction images of the scattering particles using continuous wave multispectral diffuse optical tomography with the absorption and scattering spectral prior constraints...
  99. ncbi Fast time-domain diffuse optical tomography using pseudorandom bit sequences
    Weirong Mo
    Division of Bioengineering, National University of Singapore, Singapore
    Opt Express 16:13643-50. 2008
    We report a novel time-domain diffuse optical tomography to determine the optical properties in a faster speed than the conventional ones. Instead of using the ultrashort pulse laser, a 2...
  100. ncbi Optical tomography with structured illumination
    Vladimir Lukic
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Opt Lett 34:983-5. 2009
    We consider the image reconstruction problem for optical tomography with structured illumination...
  101. ncbi Approximation errors and model reduction in optical tomography
    V Kolehmainen
    Dept of Phys, Univ Kuopio, Finland
    Conf Proc IEEE Eng Med Biol Soc 1:2659-62. 2006
    ..In this paper we apply the approximation error theory to ODT. We show that if the approximation errors are estimated and employed, it is possible to use mesh densities that would be unacceptable with a conventional measurement model...

Research Grants64

  1. Fluorescence enhanced optical tomography
    Eva M Sevick-Muraca; Fiscal Year: 2012
    ..In this renewal application, we seek to integrate innovations of frequency-domain photon migration (FDPM) optical tomography within the Siemen's Inveon system for multi-modality optical, PET, and CT small animal imaging...
  2. Time Resolved Breast Imaging Using a Combined MRI and Optical Tomography Approach
    STEFAN ALEXANDRU CARP; Fiscal Year: 2013
    ..Difference BOLD images will be cross-validated against corresponding HbR maps. The work will culminate with a clinical trial to assess the early therapy outcome predictive ability of the new biomarkers. ..
  3. Molecularly guided multimodal theranostics for breast cancer
    Amit Joshi; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: In this project we will develop a near infrared optical tomography scanner to exploit plasmonically enhanced fluorescent dyes for molecular imaging...
  4. RECOVERY OF OPTICAL ABSORPTION COEFFICIENT IN QUANTITATIVE PHOTOACOUSTIC IMAGING
    Lihong Wang; Fiscal Year: 2011
    ..focus on the following specific aims: (1) To quantify optical fluence for quantitative PAT using diffuse optical tomography (DOT);(2) To quantify optical fluence for quantitative PAT using transport optical tomography (TOT);(3) To ..
  5. Multi-Spectral Parallel-Plate Diffuse Optical Breast Tomography
    Arjun G Yodh; Fiscal Year: 2012
    ..is to assess and improve the breast tumor screening, diagnostic and monitoring capabilities of diffuse optical tomography (DOT) with near infrared (NIR) light...
  6. Application of multi-distance diffuse optical tomography to the study of human br
    Gabriele Gratton; Fiscal Year: 2013
    ..brain, based on the measurements of changes in how near-infrared light diffuses through the brain (Diffuse Optical Tomography, DOT)...
  7. Predicting Brain Recovery after Acute Hemorrhage and Resuscitation
    John J A Marota; Fiscal Year: 2010
    ..hypothesis of this proposal is that we can use information provided by magnetic resonance (MR) and diffuse optical tomography (DOT) to predict the status of brain tissue 24 hours after acute hemorrhage and resuscitation...
  8. MOLECULAR PROBES AND METHODS FOR FLUORESCENCE LIFETIME TOMOGRAPHY AND MICROSCOPY
    Samuel Achilefu; Fiscal Year: 2012
    ..Equally important is the development of a NIR fluorescence lifetime diffuse optical tomography (FLT-DOT) platform to combine quantitative optical property maps with simultane- ous reconstructions of ..
  9. Merging Diffuse Optical Tomography with EEG, MEG and MRI for Neurovascular Exams
    Solomon Gilbert Diamond; Fiscal Year: 2010
    ..Diffuse optical tomography (DOT) is an imaging extension of near-infrared spectroscopy (NIRS) that is used to measure cerebral blood ..
  10. X-ray/Fluorescence Molecular and Diffuse Optical Tomography of Glioma
    Frederic Leblond; Fiscal Year: 2012
    ..Fluorescence molecular tomography and diffuse optical tomography studies will be performed based on different optical markers potentially providing complementaryinformation...
  11. Depth-resolved Quantitative Multi-Modal Imaging for GI Cancer Detection
    Yu Chen; Fiscal Year: 2012
    ..high-resolution optical coherence tomography (OCT) and depth-resolved high-sensitivity fluorescence laminar optical tomography (FLOT) for simultaneous structural and molecular imaging...
  12. Near Infrared Diffused Light Imaging with Ultrasound Guidance: Predicting Neoadju
    Quing Zhu; Fiscal Year: 2013
    ..provided by applicant): We propose to validate the potential role of our novel near-infrared (NIR) diffuse optical tomography guided by ultrasound (NIR/US) imaging system in assessing patient pathological response to neoadjuvant ..
  13. OPTICAL IMAGING AND FUNCTIONAL CONNECTIVITY MAPPING FOR MICE
    Joseph P Culver; Fiscal Year: 2013
    ..Recently the RSFC methods have been extended to optical technology with functional connectivity diffuse optical tomography (fcDOT) demonstrated in humans...
  14. 3D Optical Imaging and Digital Xray of Breast Lesions
    David A Boas; Fiscal Year: 2013
    ..Diffuse optical tomography (or tomographic optical breast imaging) is a promising imaging modality that provides information on the ..
  15. Noninvasive Functional and Cellular Imaging of Epilepsy
    Huabei Jiang; Fiscal Year: 2013
    ..We hypothesize that diffuse optical tomography (DOT) provides a new functional and cellular neuroimaging modality for non-invasively tracking dynamical ..
  16. FREQUENCY DOMAIN OPTICAL IMAGING OF BREAST CANCER
    Keith D Paulsen; Fiscal Year: 2012
    ..Clinical results obtained to date indicate that (1) NIR optical tomography when unaided by other imaging information is not likely to achieve the performance required to improve ..
  17. Small Animal Tomography System for Green Fluorescent Protein Imaging
    Andreas H Hielscher; Fiscal Year: 2011
    ..The availability of an optical tomography system for in vivo GFP imaging would have a significant impact on this large area of research...
  18. Real-time Diffuse near-IR Optical Tomography with EEG Recordings
    Mark Farber; Fiscal Year: 2010
    ..Dynamic Near-infrared Optical Tomography (DYNOT) is a new non-invasive imaging technology that allows the researcher to explore hemodynamic changes ..
  19. Ultrahigh-resolution optical tomography of cocaine-induced neurovascular toxicity
    Yingtian Pan; Fiscal Year: 2012
    ....
  20. Neurocognitive Function and Cerebral Perfusion in Cardiac Surgery
    Daniel C Lee; Fiscal Year: 2011
    ..This project aims to utilize near- infrared optical tomography to monitor cerebral perfusion in intraoperative settings...
  21. Spectrally resolved tomographic small-animal fluorescence imager
    Craig Gardner; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This is a Fast-Track proposal to develop a multispectral optical tomography small-animal imaging system for use by the biomedical and pharmaceutical research communities...
  22. 2010 GRC on Lasers in Medicine and Biology; Gordon Research Conference
    Lihong Wang; Fiscal Year: 2010
    ..Problem driven session: endoscopy, (2) Microscopy, (3) Therapy, (4) Photoacoustic tomography, (5) Diffuse optical tomography, (6) Optical coherence tomography, (7) Contrast agents, (8) Frontier technologies, and (9) Problem driven ..
  23. RTE/FDPM for optical imaging of cancer in small animal models
    Todd Wareing; Fiscal Year: 2009
    ..Although small animal optical tomography systems have recently been introduced, current systems do not employ fluorescence or bioluminescence, which ..
  24. Computational Optical Tomography for Anti-stroke Therapy (R21/R33)
    Hanli Liu; Fiscal Year: 2009
    Recent development in diffuse optical tomography (DOT) and CCD technology may allow us to achieve high-quality, good-resolution, optical tomographic images, for which advanced 3-dimensional (3D) imaging reconstruction algorithms are ..
  25. MULTIMODAL DOT-PET MOLECULAR PROBES AND TANDEM SYSTEM
    Joseph P Culver; Fiscal Year: 2010
    ..While much progress is being made to improve standalone OI, including advances in diffuse optical tomography (DOT) methods, combining OI with well-established imaging modalities provides many po-tential advantages and ..
  26. Development of A Multi-Modality System for Onco-Imaging
    Gultekin Gulsen; Fiscal Year: 2010
    ..We have already developed a multi-frequency &multi- spectral optical tomography animal imaging system and integrated to an MRI system...
  27. Optical Fluorescence and X-Ray Computed Tomography Scanner for Small Animal In-Vi
    SETH D SHULMAN; Fiscal Year: 2012
    ..The optical parameters will be determined by (1) optical tomography in a reduced parameter space, (2) from known (oxy-)hemoglobin concentrations in different tissue types, or ..
  28. Optical Fluorescence and X-Ray Computed Tomography Scanner for Small Animal In-Vi
    SETH D SHULMAN; Fiscal Year: 2011
    ..The optical parameters will be determined by (1) optical tomography in a reduced parameter space, (2) from known (oxy-)hemoglobin concentrations in different tissue types, or ..
  29. In Vivo Optical Imaging Scanner for Small Animal Research
    STUART BERR; Fiscal Year: 2009
    ..animal optical imager with 3D reconstruction capabilities based on a computational technique called diffuse optical tomography. We propose to purchase the SPECTRUM, small animal fluorescence and bioluminescence optical scanner from ..
  30. An integrated x-ray/optical tomography system for preclinical radiation research
    John W Wong; Fiscal Year: 2013
    ..In addition to Gulmay, Caliper Life Sciences also participates as industrial consultant to capture commercialization opportunities for dissemination. ..
  31. Diffusive optical tomography (DOT) at the Biomedical Imaging Center
    Gabriele Gratton; Fiscal Year: 2010
    ..A list of major and minor users, and descriptions of the way in which they will use the new optical system, are provided with this application. ..
  32. High-resolution multi-color FLIM-FRET tomography of whole organism
    Leilei Peng; Fiscal Year: 2013
    ..tissue Fluorescence lifetime imaging (FLIM) method, named Lifetime Excitation-Emission Matrix Scanning Laser Optical Tomography (LEEM-SLOT) to: 1. Perform isotropic sub-cellular 3D imaging in deep tissue, 2...
  33. X-ray Luminescence Optical Tomography for Small Animal Imaging
    Changqing Li; Fiscal Year: 2012
    ..We propose a hybrid imaging modality, X-ray luminescence optical tomography (XLOT), to image X-ray excitable nanoparticles in turbid media with both high molecular contrast sensitivity ..
  34. "3D Camera Ring" - Novel Automated 360-degree Surface Profiling System for Small
    Gongjie Yin; Fiscal Year: 2011
    ..Advanced diffuse optical tomography (DOT) algorithms require good a priori knowledge of the boundary geometry of the diffuse medium being imaged ..
  35. Integrated Center for InVivo Microscopy
    GEORGE ALLAN JOHNSON; Fiscal Year: 2011
    ..microscopy;Core B - Functional pulmonary MR imaging with hyperpolarized gas;Core C - Combined x-ray and optical tomography with the Molecular Imaging Workbench;and Core D - Integration...
  36. RESOLUTION LIMITS FOR FLUORESCENCE TOMOGRAPHIC MOLECULAR IMAGING
    XIAOFENG STEVE ZHANG; Fiscal Year: 2012
    ..by applicant): We are proposing studies to determine the resolution limits for fluorescence diffuse optical tomography (FDOT) using over-sampled measurements...
  37. RESOLUTION LIMITS FOR FLUORESCENCE TOMOGRAPHIC MOLECULAR IMAGING
    XIAOFENG STEVE ZHANG; Fiscal Year: 2011
    ..by applicant): We are proposing studies to determine the resolution limits for fluorescence diffuse optical tomography (FDOT) using over-sampled measurements...
  38. IVIS Spectrum Imaging System
    JOSEPH ANDREW SPERNYAK; Fiscal Year: 2013
    ..unmixing capabilities, c) quantitative fluorescent imaging via trans- illumination techniques and d) 3D optical tomography for localization of emission signal and co- registration to magnetic resonance imaging data...
  39. OPTICAL TOMOGRAPHY FOR THE DIAGNOSIS OF JOINT DISEASES
    ANDREAS HIELSCHER; Fiscal Year: 2007
    ..erosion, and hypertrophy of the synovial membrane (synovitis)) that accompany RA can be distinguished by optical tomography (OT)...
  40. Modeling the photon propagation for optical molecular imaging
    Wenxiang Cong; Fiscal Year: 2009
    ..The model mismatch would have the most adverse effect on image quality in solving ill-posed optical tomography problems. Currently, there is no photon propagation model that is well-rounded for optical molecular imaging...
  41. High-resolution ultrasound-encoded optical tomography
    Lihong Wang; Fiscal Year: 2003
    ..The proposed technology--a quantum leap from the state of the art--is complementary to confocal microscopy and optical-coherence tomography and has the potential for broad application in biomedicine. ..
  42. 3D Imaging of electrical activity in myocardial tissue
    Arkady Pertsov; Fiscal Year: 2007
    ..D. Boas at the Harvard Medical School and the Massachusetts General Hospital NMR Center, an expert in optical tomography; Dr. L...
  43. Optical Tomography of Intrinsic Signals in Rat Cortex
    Bruce J Tromberg; Fiscal Year: 2013
    ..We will optimize our tomographic image reconstruction methods to work in the rat cortex using dynamic tissue simulating phantoms, and validate our approach using our established protocol for whisker stimulation in the adult rat. ..
  44. System Upgrade for Small-Animal MRI
    Joseph Ackerman; Fiscal Year: 2007
    ..Imaging Resource, which was established specifically to address the need for MRI, PET and, more recently, optical tomography and CT of small laboratory animal models...
  45. SUPERHEATED DROP DETECTORS FOR DOSIMETRY IN RADIOTHERAPY
    Ravinder Nath; Fiscal Year: 2005
    ..technique for rapid pressure cycling and high-speed image acquisition using 3D-echo planar imaging and optical tomography will be used to improve statistical accuracy and spatial resolution...
  46. Image Reconstruction Algorithms for Optical Tomography
    JOHN SCHOTLAND; Fiscal Year: 2009
    ..to solve the problem of developing computationally efficient image reconstruction algorithms for noncontact optical tomography (OT) with large data sets...
  47. TRAINING IN INNOVATIVE CANCER IMAGING TECHNOLOGIES
    Stanley Baum; Fiscal Year: 2000
    ..training in the theory and implementation of magnetic resonance (MR), ultrasound, computed tomography (CT), optical tomography (OT), positron emission tomography (PET), and single photon emission computed tomography (SPECT), the ..
  48. Optical Tomography for Diagnosis of NEC
    Randall Barbour; Fiscal Year: 2006
    This Phase I study explores the feasibility by which the technique of dynamic near-infrared optical tomography (DYNOT) can be employed as an accurate, noninvasive tool to assess tissue perfusion of small bowel in neonatal patients at risk ..
  49. DET/COMPUTATION FOR DIFFUSE OPTICAL TOMOGRAPHY OF BREAST
    Arjun Yodh; Fiscal Year: 2002
    ..two years of the original application, the applicants investigated the angular spectrum approach for diffuse optical tomography of the human breast in the parallel plate (compressed breast) geometry...
  50. Small Animal Tomography System for Green Fluorescent Protein Imaging
    ANDREAS HIELSCHER; Fiscal Year: 2007
    ..The availability of an optical tomography system for in vivo GFP imaging would have a significant impact on this large area of research...
  51. Complex differential spectral interferometry
    Daniel Kane; Fiscal Year: 2004
    ..The method, complex differential spectral interferometry (CDSI), is a frequency domain optical tomography method that is an improvement over both time domain optical coherence tomography (OCT) and spectral ..
  52. SPECTROSCOPY FOR ALZHEIMER'S DISEASE DIAGNOSIS
    Michael Feld; Fiscal Year: 2001
    ..Researchers developing cerebral oxygen monitors and studying brain optical tomography have shown that brain tissue is highly translucent to NIR wavelengths and that sufficient light can be ..
  53. Noninvasive imaging of tissue-engineered blood vessels
    Mark Haidekker; Fiscal Year: 2007
    ..The purpose of this project is to develop and refine methods based on transillumination optical tomography (OT) and optical coherence tomography (OCT) for thin tissue samples (vascular grafts are 300 - 500 Lim thick)..
  54. Accuracy of Diffuse Optical Tomography Using 3d camera
    STEVEN YI; Fiscal Year: 2006
    ..proposed herein is to investigate the feasibility of significantly enhancing the imaging capacity of diffuse optical tomography (DOT) technology by using a novel 3D image device to provide accurate three-dimensional (3D) geometric ..
  55. Optical Tomography in Resuscitation Management/Diagnosis
    HARRY GRABER; Fiscal Year: 2005
    This Phase I study explores the feasibility by which the technique of dynamic near-infrared optical tomography (DYNOT) can be employed as an accurate, noninvasive tool to assess tissue perfusion and vascular resistance to aid in the ..
  56. OPTICAL IMAGING OF BRAIN FUNCTION IN THE PRETERM INFANT
    Joseph Culver; Fiscal Year: 2009
    ..We have recently developed a new high-performance diffuse optical tomography (DOT) system that overcomes these challenges and provides significant improvements in resolution and signal ..
  57. Small animal fluorescence enhanced optical tomography
    Eva Sevick Muraca; Fiscal Year: 2006
    ..If successful, this project will provide the first validation of optical tomography in a preclinical model of metastatic cancer. [unreadable] [unreadable] [unreadable]
  58. FULL-FIELD MUELLER-MATRIX TOMOGRAPHY
    Lihong Wang; Fiscal Year: 2001
    ..b>Optical tomography in biological tissues is very challenging because light is strongly scattering in tissues...
  59. Tomographic NIR Fluorescence Enhanced Imaging
    Ranadhir Roy; Fiscal Year: 2005
    Over the past two years, the development of optical tomography using near-infrared excitable fluorescent contrast agents has progressed in a few laboratories using re-emitted fluorescence measurements at single point positions surrounding ..
  60. Full 360-degree Surface Imaging System for Small Animal
    Hui Li; Fiscal Year: 2004
    ..3D) surface imaging system for acquiring complete 3D surface profiles of a small animal undergoing in vivo optical tomography imaging procedures...
  61. NearIR Photon-counting Camera for Diffuse Optical Tomography
    James Christian; Fiscal Year: 2007
    ..Diffuse optical tomography (DOT) and diffuse correlation tomography (DCT), which images blood flow, promises to provide a method for ..
  62. Diffused Optical Tomography using Oxygen-sensitive Luminescent Contrast Agent for
    RAJAN GURJAR; Fiscal Year: 2007
    ..work, we will focus on detecting and imaging hypoxic breast cancer using near-infrared (NIR) based diffused optical tomography (DOT) technique...
  63. Training in Cancer Imaging with Novel Techniques
    Abass Alavi; Fiscal Year: 2007
    ..In addition to training in the theory and applications of MR, ultrasound, CT, optical tomography, PET, SPECT, and small animal imaging (PET, SPECT, MRI, and CT), the trainees will be exposed to a broad ..
  64. A Storage Area Network for Structural and Functional Image Analysis
    Bruce Fischl; Fiscal Year: 2009
    ..integration studies (to facilitate complex forward and inverse modeling used in EEG/MEG/fMRI and diffuse optical tomography), and d) algorithm development users (to allow large parameter spaces to be explored in parallel without ..