near infrared spectroscopy

Summary

Summary: A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.

Top Publications

  1. ncbi Social perception in infancy: a near infrared spectroscopy study
    Sarah Lloyd-Fox
    Centre for Brain and Cognitive Development, Birkbeck, University of London, London, United Kingdom
    Child Dev 80:986-99. 2009
  2. ncbi Illuminating the developing brain: the past, present and future of functional near infrared spectroscopy
    S Lloyd-Fox
    Centre for Brain and Cognitive Development, Birkbeck, University of London, Malet Street, Birkbeck WC1E 7HX, United Kingdom
    Neurosci Biobehav Rev 34:269-84. 2010
  3. ncbi Multichannel near-infrared spectroscopy in depression and schizophrenia: cognitive brain activation study
    Tomohiro Suto
    Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Gunma, Japan
    Biol Psychiatry 55:501-11. 2004
  4. ncbi Correlates of alpha rhythm in functional magnetic resonance imaging and near infrared spectroscopy
    Matthias Moosmann
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    Neuroimage 20:145-58. 2003
  5. pmc Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy
    B J Tromberg
    Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine 92612 1475, USA
    Neoplasia 2:26-40. 2000
  6. ncbi Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model
    Y Hoshi
    Biophysics Group, Research Institute for Electronic Science, Hokkaido University, Sapporo 060 0812, Japan
    J Appl Physiol (1985) 90:1657-62. 2001
  7. ncbi Beyond the visible--imaging the human brain with light
    Hellmuth Obrig
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    J Cereb Blood Flow Metab 23:1-18. 2003
  8. ncbi Principles, techniques, and limitations of near infrared spectroscopy
    Marco Ferrari
    Department of Biomedical Sciences and Technologies, University of L Aquila, Italy
    Can J Appl Physiol 29:463-87. 2004
  9. ncbi Performance of near-infrared spectroscopy in measuring local O(2) consumption and blood flow in skeletal muscle
    M C van Beekvelt
    Department of Physiology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands
    J Appl Physiol (1985) 90:511-9. 2001
  10. ncbi Monte Carlo prediction of near-infrared light propagation in realistic adult and neonatal head models
    Yuich Fukui
    Department of Electronics and Electrical Engineering, Keio University, 3 141, Hyoshi, Kohoku Ku, Yokohama 223 8522, Japan
    Appl Opt 42:2881-7. 2003

Detail Information

Publications301 found, 100 shown here

  1. ncbi Social perception in infancy: a near infrared spectroscopy study
    Sarah Lloyd-Fox
    Centre for Brain and Cognitive Development, Birkbeck, University of London, London, United Kingdom
    Child Dev 80:986-99. 2009
    ..This study used near infrared spectroscopy to investigate functional activation in the social brain network of 36 five-month-old infants...
  2. ncbi Illuminating the developing brain: the past, present and future of functional near infrared spectroscopy
    S Lloyd-Fox
    Centre for Brain and Cognitive Development, Birkbeck, University of London, Malet Street, Birkbeck WC1E 7HX, United Kingdom
    Neurosci Biobehav Rev 34:269-84. 2010
    A decade has passed since near infrared spectroscopy (NIRS) was first applied to functional brain imaging in infants...
  3. ncbi Multichannel near-infrared spectroscopy in depression and schizophrenia: cognitive brain activation study
    Tomohiro Suto
    Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Gunma, Japan
    Biol Psychiatry 55:501-11. 2004
    ..Recent developments in near-infrared spectroscopy (NIRS) have enabled the noninvasive clarification of brain functions in psychiatric disorders with measurement of hemoglobin concentrations as cerebral blood volume...
  4. ncbi Correlates of alpha rhythm in functional magnetic resonance imaging and near infrared spectroscopy
    Matthias Moosmann
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    Neuroimage 20:145-58. 2003
    We used simultaneous electroencephalogram-functional magnetic resonance imaging (EEG-fMRI) and EEG-near infrared spectroscopy (NIRS) to investigate whether changes of the posterior EEG alpha rhythm are correlated with changes in local ..
  5. pmc Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy
    B J Tromberg
    Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine 92612 1475, USA
    Neoplasia 2:26-40. 2000
    ..Measurements provide quantitative optical property values that reflect changes in tissue perfusion, oxygen consumption, and cell/matrix development...
  6. ncbi Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model
    Y Hoshi
    Biophysics Group, Research Institute for Electronic Science, Hokkaido University, Sapporo 060 0812, Japan
    J Appl Physiol (1985) 90:1657-62. 2001
    ....
  7. ncbi Beyond the visible--imaging the human brain with light
    Hellmuth Obrig
    Department of Neurology, Charite, Humboldt University, Berlin, Germany
    J Cereb Blood Flow Metab 23:1-18. 2003
    ..The authors conclude that NIRS imaging has two major advantages: it can address issues concerning neurovascular coupling in the human adult and can extend functional imaging approaches to the investigation of the diseased brain...
  8. ncbi Principles, techniques, and limitations of near infrared spectroscopy
    Marco Ferrari
    Department of Biomedical Sciences and Technologies, University of L Aquila, Italy
    Can J Appl Physiol 29:463-87. 2004
    ..The possibility of measuring the cortical activation in response to different stimuli, and the changes in the cortical cytochrome oxidase redox state upon O2 delivery changes, will also be mentioned...
  9. ncbi Performance of near-infrared spectroscopy in measuring local O(2) consumption and blood flow in skeletal muscle
    M C van Beekvelt
    Department of Physiology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands
    J Appl Physiol (1985) 90:511-9. 2001
    ....
  10. ncbi Monte Carlo prediction of near-infrared light propagation in realistic adult and neonatal head models
    Yuich Fukui
    Department of Electronics and Electrical Engineering, Keio University, 3 141, Hyoshi, Kohoku Ku, Yokohama 223 8522, Japan
    Appl Opt 42:2881-7. 2003
    ..The intensely sensitive region in the neonatal brain is confined to the gray matter; however, the spatial sensitivity profile penetrates into the deeper region of the white matter...
  11. ncbi A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies
    Yves Roggo
    F Hoffmann La Roche Ltd, Basel, Switzerland
    J Pharm Biomed Anal 44:683-700. 2007
    ..The following topics are covered: qualitative analyses, quantitative methods and on-line applications. Theoretical and practical aspects are described with pharmaceutical examples of NIRS applications...
  12. ncbi A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation
    Gary Strangman
    Neural Systems Group, NMR Center, Massachusetts General Hospital Harvard Medical School, Harvard MIT Division of Health Sciences and Technology, Charlestown 02129, USA
    Neuroimage 17:719-31. 2002
    ..This may reflect, at least in part, the superior contrast-to-noise ratio for oxyhemoglobin relative to deoxyhemoglobin (from optical measurements), rather than physiology related to BOLD signal interpretation...
  13. ncbi Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands
    A Becker
    , 14050 Berlin, Germany
    Nat Biotechnol 19:327-31. 2001
    ..This imaging approach, combining the specificity of ligand/receptor interaction with near-infrared fluorescence detection, may be applied in various other fields of cancer diagnosis...
  14. ncbi Reproducibility of the blood flow index as noninvasive, bedside estimation of cerebral blood flow
    Bendicht P Wagner
    Pediatric Intensive Care, Department of Pediatrics, Inselspital, University of Berne, 3010, Berne, Switzerland
    Intensive Care Med 29:196-200. 2003
    ..To investigate the feasibility and reproducibility of the blood flow index (BFI) method for measuring cerebral blood flow...
  15. ncbi Comparison of calibrations for the determination of soluble solids content and pH of rice vinegars using visible and short-wave near infrared spectroscopy
    Fei Liu
    College of Biosystems Engineering and Food Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, China
    Anal Chim Acta 610:196-204. 2008
    ..008 and -1.7 x 10(-3) for pH, respectively. The overall results indicated that Vis/SWNIR spectroscopy combined with LS-SVM could be applied as a high precision and fast way for the determination of SSC and pH values of rice vinegars...
  16. ncbi Monitoring tissue oxygen availability with near infrared spectroscopy (NIRS) in health and disease
    R Boushel
    Sports Medicine Research Unit, Bispebjerg University Hospital, Copenhagen Muscle Research Center, Denmark
    Scand J Med Sci Sports 11:213-22. 2001
    b>Near infrared spectroscopy (NIRS) is becoming a widely used research instrument to measure tissue oxygen (O2) status non-invasively...
  17. ncbi Event-related functional near-infrared spectroscopy (fNIRS): are the measurements reliable?
    M M Plichta
    Department of Psychiatry and Psychotherapy, Laboratory for Psychophysiology and Functional Imaging, University Hospital Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Neuroimage 31:116-24. 2006
    ..Furthermore, the reliability assessed by single measurement ICCs improved if regarded at a cluster level...
  18. ncbi Near-infrared spectroscopic quantification of changes in the concentration of oxidized cytochrome c oxidase in the healthy human brain during hypoxemia
    Martin M Tisdall
    The National Hospital for Neurology and Neurosurgery, Department of Neuroanaesthesia and Neurocritical Care, Queen Square, London WC1N 3BG, United Kingdom
    J Biomed Opt 12:024002. 2007
    ..This is the first description of cerebral Delta[oxCCO] during hypoxemia in healthy adults. Studies are ongoing to investigate the clinical relevance of this signal in patients with traumatic brain injury...
  19. ncbi Cerebral oxygenation and electrical activity after birth asphyxia: their relation to outcome
    Mona C Toet
    Department of Neonatology, University Medical Center Utrecht Wilhelmina Children s Hospital, Utrecht, The Netherlands
    Pediatrics 117:333-9. 2006
    ....
  20. ncbi Relation between asymmetry of prefrontal cortex activities and the autonomic nervous system during a mental arithmetic task: near infrared spectroscopy study
    Masahiro Tanida
    Bioengineering Research Laboratories, Shiseido Life Science Research Center, 2 2 1 Hayabuchi, Tsuzuki ku, Yokohama 224 8558, Japan
    Neurosci Lett 369:69-74. 2004
    ..Employing near infrared spectroscopy, we compared cerebral blood oxygenation changes in the right and left prefrontal cortices during a ..
  21. ncbi Design and implementation of dynamic near-infrared optical tomographic imaging instrumentation for simultaneous dual-breast measurements
    Christoph H Schmitz
    NIRx Technologies, LLC, New York 11545, USA
    Appl Opt 44:2140-53. 2005
    ..We present exemplary clinical results comparing the measured physiologic response of a healthy individual and of a subject with breast cancer to a Valsalva maneuver...
  22. ncbi Near-infrared spectroscopy measurement of oxygen extraction fraction and cerebral metabolic rate of oxygen in newborn piglets
    Derek W Brown
    Imaging Division, Lawson Health Research Institute, London, Ontario, Canada
    Pediatr Res 54:861-7. 2003
    ..The proficiency of NIRS in the measurement of OEF and CMRO2 was demonstrated through the observation of transient increases in OEF, which served to maintain CMRO2 during indomethacin-induced reductions in CBF...
  23. pmc Functional near infrared spectroscopy (NIRS) signal improvement based on negative correlation between oxygenated and deoxygenated hemoglobin dynamics
    Xu Cui
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA
    Neuroimage 49:3039-46. 2010
    b>Near infrared spectroscopy (NIRS) is a promising technology for functional brain imaging which measures hemodynamic signals from the cortex, similar to functional magnetic resonance imaging (fMRI), but does not require the participant to ..
  24. pmc Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy
    Albert Cerussi
    Laser Medical and Microbeam Program, Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
    Proc Natl Acad Sci U S A 104:4014-9. 2007
    ..44) vs. nonresponders (1.82 +/- 0.49). These results highlight DOS sensitivity to tumor cellular metabolism and biochemical composition and demonstrate its potential for predicting and monitoring an individual's response to treatment...
  25. pmc Brain cortical mapping by simultaneous recording of functional near infrared spectroscopy and electroencephalograms from the whole brain during right median nerve stimulation
    Mikinobu Takeuchi
    System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
    Brain Topogr 22:197-214. 2009
    ..hemodynamic responses and neural activities in the somatosensory cortices, hemodynamic responses by near infrared spectroscopy (NIRS) and electroencephalograms (EEGs) were recorded simultaneously while subjects received electrical ..
  26. ncbi Near infrared spectroscopy and aquaphotomics: Novel approach for rapid in vivo diagnosis of virus infected soybean
    Balasuriya Jinendra
    Department of Environmental Information and Bio production Engineering, Kobe University, 1 1 Rokko dai, CHO, 657 8501, Japan
    Biochem Biophys Res Commun 397:685-90. 2010
    b>Near infrared spectroscopy with aquaphotomics as a novel approach was assessed for the diagnosis of soybean plants (Glycine max) infected with soybean mosaic virus (SMV) at latent symptomless stage of the disease...
  27. ncbi Wavelet analysis of cerebral oxygenation signal measured by near infrared spectroscopy in subjects with cerebral infarction
    Zengyong Li
    School of Mechanical Engineering, Shandong University, Jinan, PR China
    Microvasc Res 80:142-7. 2010
    ..oxygenation oscillations in subjects with cerebral infarction (CI) based on the wavelet transform of near infrared spectroscopy (NIRS) signals...
  28. ncbi Quality control and assurance in functional near infrared spectroscopy (fNIRS) experimentation
    F Orihuela-Espina
    Division of Surgery, Oncology, Reproductive Biology and Anaesthetics SORA, Imperial College, London, UK
    Phys Med Biol 55:3701-24. 2010
    Functional near infrared spectroscopy (fNIRS) is a rapidly developing neuroimaging modality for exploring cortical brain behaviour...
  29. ncbi [Changes in cerebral near infrared spectroscopy parameters during manual acupuncture needle stimulation]
    G Litscher
    Biomedizintechnische Forschung, Universitätsklinik für Anästhesiologie und Intensivmedizin Graz, Austria
    Biomed Tech (Berl) 47:76-9. 2002
    ..The results demonstrate that near-infrared spectroscopy may be a noninvasive method of measuring regional changes in cerebral haemodynamics resulting from peripheral acupuncture stimulation...
  30. ncbi [Cerebral near infrared spectroscopy and acupuncture--results of a pilot study]
    G Litscher
    Universitätsklinik für Anästhesiologie und Intensivmedizin Graz
    Biomed Tech (Berl) 45:215-8. 2000
    ..However, needling and laser puncture at placebo points does not produce the same effect on cerebral oxygenation. This fact provides further proof of specific quantifiable effects of acupuncture on the brain...
  31. ncbi Near infrared spectroscopy for bioprocess monitoring and control: current status and future trends
    Matthew Scarff
    Strathclyde Fermentation Centre, University of Strathclyde, 204 George Street, Glasgow G1 1XW, UK
    Crit Rev Biotechnol 26:17-39. 2006
    The development of Near Infrared Spectroscopy has paralleled that of the PC, and the application of NIR in many industries has undergone explosive growth in recent years...
  32. ncbi Near infrared spectroscopy monitoring during carotid endarterectomy: which threshold value is critical?
    T Mille
    Operative Unit of Clinical Neurophysiology, Neurosurgery Division, Department of Surgery, IRCCS Policlinico S Matteo, Pavia, Italy
    Eur J Vasc Endovasc Surg 27:646-50. 2004
    ..Retrospectively to verify which decreasing percentage in regional oxygen saturation (rSO(2)) identified patients with good collateralisation during carotid artery cross clamp...
  33. ncbi Neural activation to upright and inverted faces in infants measured by near infrared spectroscopy
    Yumiko Otsuka
    Department of Psychology, Chuo University, Tokyo, Japan
    Neuroimage 34:399-406. 2007
    The present study examined infants' brain activity in response to upright and inverted faces using near infrared spectroscopy (NIRS), which can non-invasively record hemodynamic changes of the brain...
  34. ncbi Motion artifact removal for functional near infrared spectroscopy: a comparison of methods
    F C Robertson
    Medical Research Council University of Cape Town Medical Imaging Research Unit, Department of Human Biology, University of Cape Town, Observatory 7935, South Africa
    IEEE Trans Biomed Eng 57:1377-87. 2010
    b>Near infrared spectroscopy (NIRS) is rapidly gaining popularity for functional brain imaging. It is well suited to studies of patients or children; however, in these populations particularly, motion artifacts can present a problem...
  35. ncbi Mapping of optical pathlength of human adult head at multi-wavelengths in near infrared spectroscopy
    Akihisa Katagiri
    Division of Neurological Surgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Adv Exp Med Biol 662:205-12. 2010
    ..The current study suggests the importance of considering PL differences in interpreting functional data obtained by CW-NIRS...
  36. ncbi Cerebral blood oxygenation changes induced by auditory stimulation in newborn infants measured by near infrared spectroscopy
    K Sakatani
    Department of Neurosurgery, China Japan Friendship Hospital, Hepingli, Beijing, People s Republic of China
    Early Hum Dev 55:229-36. 1999
    Recent neuronal activation studies on newborns using functional MRI or near infrared spectroscopy (NIRS) have suggested that the increase in O2 consumption accompanying neuronal activation exceeds the increase in O2 delivery in the visual ..
  37. ncbi Bulk optical properties of healthy female breast tissue
    T Durduran
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
    Phys Med Biol 47:2847-61. 2002
    ..The new information on healthy breast tissue provides insight about the potential contrasts available for diffuse optical tomography of breast tumours...
  38. ncbi The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics
    D A Boas
    NMR Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neuroimage 13:76-90. 2001
    b>Near infrared spectroscopy (NIRS) can detect changes in the concentrations of oxy-hemoglobin ([HbO]) and deoxy-hemoglobin ([Hb]) in tissue based upon differential absorption at multiple wavelengths...
  39. ncbi Functional near infrared spectroscopy (fNIRS): an emerging neuroimaging technology with important applications for the study of brain disorders
    Farzin Irani
    Department of Psychology, Drexel University, Philadelphia, PA 19104, USA
    Clin Neuropsychol 21:9-37. 2007
    ....
  40. ncbi Spectroscopy enhances the information content of optical mammography
    A E Cerussi
    University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Rd, Irvine, California 92612, USA
    J Biomed Opt 7:60-71. 2002
    ..Multi-spectral measurements, compared to measurements restricted to one or two wavelengths, provide additional information that may be useful in managing breast disease...
  41. ncbi Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise
    Andrew W Subudhi
    Department of Biology, University of Colorado Altitude Research Center, Denver Health Science Center and Colorado Springs Campuses, Colorado 80918, USA
    J Appl Physiol (1985) 103:177-83. 2007
    ..On the basis of these findings, it is unlikely that changes in cerebral oxygenation limit incremental exercise performance in normoxia, yet it is possible that such changes play a more pivotal role in hypoxia...
  42. ncbi Infant's brain responses to live and televised action
    Sotaro Shimada
    Department of General System Studies, The University of Tokyo, 3 4 1, Komaba, Meguro ku, Tokyo, 153 8902, Japan
    Neuroimage 32:930-9. 2006
    ..Our results are the first to demonstrate activation in motor areas during action observation in human infants. We suggest that human brain responds differently to the real world and the virtual world...
  43. ncbi Prefrontal activation due to Stroop interference increases during development--an event-related fNIRS study
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
    Neuroimage 23:1317-25. 2004
    ..In conclusion, our results indicate that neuromaturational processes regarding resolution of Stroop interference may depend on increased ability to recruit frontal neural resources...
  44. ncbi Muscle perfusion and oxygen consumption by near-infrared spectroscopy in septic-shock and non-septic-shock patients
    Massimo Girardis
    Servizio di Anestesia e Rianimazione 1, Policlinico di Modena, L go del Pozzo 71, 41100, Modena, Italy
    Intensive Care Med 29:1173-6. 2003
    ..To measure muscle blood flow (Qtis) and oxygen consumption (VO(2)tis) in septic and non-septic critically ill patients by near-infrared spectroscopy (NIRS)...
  45. ncbi Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study
    Britton Chance
    University of Pennsylvania, Department of Biochemistry, Philadelphia, 19104 6059, USA
    Acad Radiol 12:925-33. 2005
    ....
  46. ncbi Auditory-evoked cerebral oxygenation changes in hypoxic-ischemic encephalopathy of newborn infants monitored by near infrared spectroscopy
    Saying Chen
    Department of Pediatrics, China Japan Friendship Hospital, Hepingli, Beijing, China
    Early Hum Dev 67:113-21. 2002
    ..In the present study, using near infrared spectroscopy (NIRS), we evaluated the evoked cerebral blood oxygenation (CBO) changes in hypoxic-ischemic ..
  47. ncbi In vivo molecular target assessment of matrix metalloproteinase inhibition
    C Bremer
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Med 7:743-8. 2001
    ..The developed probes, together with novel near-infrared fluorescence imaging technology will enable the detailed analysis of a number of proteinases critical for advancing the therapeutic use of clinical proteinase inhibitors...
  48. pmc Shining new light on the brain's "bilingual signature": a functional Near Infrared Spectroscopy investigation of semantic processing
    Ioulia Kovelman
    Massachusetts Institute of Technology, MA, USA
    Neuroimage 39:1457-71. 2008
    ..and is this affected by the language context? Using an innovative brain imaging technology, functional Near Infrared Spectroscopy (fNIRS), we investigated how adult bilinguals process semantic information, both in speech and in print, ..
  49. ncbi Thenar oxygen saturation measured by near infrared spectroscopy as a noninvasive predictor of low central venous oxygen saturation in septic patients
    Jaume Mesquida
    Critical Care Center, Hospital de Sabadell, Corporacio Parc Tauli, Institut Universitari Parc Tauli, CIBER Enfermedades Respiratorias, Universitat Autonoma de Barcelona, Parc Tauli s n, 08208 Sabadell, Spain
    Intensive Care Med 35:1106-9. 2009
    ..To validate thenar oxygen saturation (StO(2)) measured by near-infrared spectroscopy (NIRS) as a noninvasive estimation of central venous saturation (ScvO(2)) in septic patients...
  50. ncbi Determination of effective wavelengths for discrimination of fruit vinegars using near infrared spectroscopy and multivariate analysis
    Fei Liu
    College of Biosystems Engineering and Food Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310029, China
    Anal Chim Acta 615:10-7. 2008
    ..NIR spectroscopy combined with LS-SVM models had the capability to discriminate the varieties of fruit vinegars with high accuracy...
  51. ncbi Noninvasive monitoring of cerebral blood flow by a dye bolus method: separation of brain from skin and skull signals
    Matthias Kohl-Bareis
    Humboldt University, Charite Hospital, Department of Neurology, Schumannstrasse 20 21, 10117 Berlin, Germany
    J Biomed Opt 7:464-70. 2002
    ..Here we study optical absorption changes induced by a bolus of the dye indocyanine-green with near infrared spectroscopy in healthy volunteers. The aim is to assess the latency and shape of the change in absorption...
  52. ncbi Near Infrared Spectroscopy in healthy preterm and term newborns: correlation with gestational age and standard monitoring parameters
    Lucia Gabriella Tina
    Department of Maternal, Fetal and Neonatal Medicine, G Garibaldi Hospital, Catania, Italy
    Curr Neurovasc Res 6:148-54. 2009
    b>Near Infrared Spectroscopy (NIRS) is an emerging technique for brain oxygenation monitoring in newborns complicated by acute and chronic hypoxia...
  53. ncbi Muscle oxygenation and glycolysis in females with trapezius myalgia during stress and repetitive work using microdialysis and NIRS
    Gisela Sjøgaard
    Institute of Sport Sciences and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark
    Eur J Appl Physiol 108:657-69. 2010
    ..Higher relative muscle load during PEG and STR, insufficient muscle blood flow and oxygenation may account for the higher lactate, pyruvate and pain responses among MYA versus CON...
  54. ncbi Prefrontal brain activation during stop-signal response inhibition: an event-related functional near-infrared spectroscopy study
    Maren Boecker
    Department of Medical Psychology and Medical Sociology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Behav Brain Res 176:259-66. 2007
    ..The findings indicate that NIRS is suitable for the functional identification of prefrontal activation during the inhibition of initiated responses and provide further support for the contribution of the PFC to response inhibition...
  55. ncbi Non-invasive neuroimaging using near-infrared light
    Gary Strangman
    Neural Systems Group, Massachusetts General Hospital, Harvard Medical School and Harvard MIT Division of Health Sciences and Technology, Charlestown, MA 02129, USA
    Biol Psychiatry 52:679-93. 2002
    ..We find that, while diffuse optics can provide substantial advantages to the psychiatric researcher relative to the alternative brain imaging methods, the method remains substantially underutilized in this field...
  56. ncbi Application of a hybrid variable selection method for determination of carbohydrate content in soy milk powder using visible and near infrared spectroscopy
    Xiaojing Chen
    College of Physics and Electronic Information and Department of Chemistry, Wenzhou University, China
    J Agric Food Chem 57:334-40. 2009
    ..The results indicated that Vis-NIR spectroscopy could efficiently determine the carbohydrate content in soy milk powder. The WPT-OB-SA selection method eliminated redundant variables and improved the prediction ability...
  57. ncbi Near infrared spectroscopy in large animals: optical pathlength and influence of hair covering and epidermal pigmentation
    J Pringle
    Service of Physiology, Faculty of Veterinary Medicine, Bât 42, Bât 42, B 4000, Belgium
    Vet J 158:48-52. 1999
    ..05). These results show that NIRS is possible through lighter pigmented hair and epidermal tissues, and provide DPFs of horse feet and muscle and the sheep head that enables quantitative NIRS in these species..
  58. ncbi Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument
    D M Hueber
    University of Pennsylvania, School of Medicine in Philadelphia, USA
    Phys Med Biol 46:41-62. 2001
    ..The origin of this 'effective' background absorption may be real, an artefact caused by the application of a simplified model to a complex sample, or a combination of factors...
  59. pmc Methodology development for three-dimensional MR-guided near infrared spectroscopy of breast tumors
    Colin M Carpenter
    Thayer School of Engineering, Dartmouth College Hanover, NH 03755, USA
    Opt Express 16:17903-14. 2008
    Combined Magnetic Resonance (MR) and Near Infrared Spectroscopy (NIRS) has been proposed as a unique method to quantify hemodynamics, water content, and cellular size and packing density of breast tumors, as these tissue constituents can ..
  60. ncbi Near-infrared spectroscopy: does it function in functional activation studies of the adult brain?
    H Obrig
    Department of Neurology, Charite, Humboldt Universitat zu Berlin, 10098, Berlin, Germany
    Int J Psychophysiol 35:125-42. 2000
    ..Some of the work described here has been published elsewhere...
  61. ncbi Measurement of oxygen saturation in venous blood by dynamic near infrared spectroscopy
    M Nitzan
    Department of Physics Electro Optics, Jerusalem College of Technology, Israel
    J Biomed Opt 5:155-62. 2000
    ..These SvO2 values are reasonable for the finger and the hand where arterio-venous anastomoses exist. The method enables the measurement of SvO2 in the limbs, a parameter which is related to tissue blood flow and oxygen consumption...
  62. ncbi Changes in cerebral hemoglobin concentration and oxygen saturation immediately after birth in the human neonate using full-spectrum near infrared spectroscopy
    K Isobe
    Kagawa Medical University, Department of Pediatrics and Maternal and Children s Center, Kitagun, Japan
    J Biomed Opt 5:283-6. 2000
    Using full-spectrum near infrared spectroscopy (fsNIRS), we measured changes in oxy- and deoxyhemoglobin (HbO2 and Hb), total hemoglobin (T-Hb) concentration, and hemoglobin oxygen saturation (SbO2) in the brain tissue of seven neonates ..
  63. ncbi In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction
    Subhadra Srinivasan
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Acad Radiol 13:195-202. 2006
    ....
  64. ncbi In-situ near infrared spectroscopy to monitor key analytes in mammalian cell cultivation
    S Alison Arnold
    Strathclyde Fermentation Centre, Department of Bioscience and Biotechnology, University of Strathclyde, 204 George Street, Glasgow G1 1XW, United Kingdom
    Biotechnol Bioeng 84:13-9. 2003
    The use of in-situ near infrared spectroscopy (NIRS) as a tool for monitoring four key analytes in a CHO-K1 animal cell culture was investigated...
  65. ncbi Challenging near infrared spectroscopy discriminating ability for counterfeit pharmaceuticals detection
    I Storme-Paris
    Groupe de Chimie Analytique de Paris Sud, EA 4041, IFR 141, School of Pharmacy, Univ Paris Sud, 5 Rue Jean Baptiste Clement, 92296 Chatenay Malabry, France
    Anal Chim Acta 658:163-74. 2010
    ..To test the discriminating ability of Near InfraRed Spectroscopy (NIRS), worse cases scenarios were first considered for the discrimination of various pharmaceutical ..
  66. ncbi In situ near infrared spectroscopy for analyte-specific monitoring of glucose and ammonium in streptomyces coelicolor fermentations
    Nanna Petersen
    Dept of Chemical and Biochemical Engineering, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Biotechnol Prog 26:263-71. 2010
    ..For improved predictions of ammonium in situ, it is suggested to focus efforts on enhancing the signal in that particular region...
  67. ncbi Near infrared spectroscopy study of the central nervous activity during artificial changes in bladder sensation in men
    Shinya Matsumoto
    Department of Urology, The University of Tokyo Hospital, Bunkyo ku, Tokyo, Japan
    Int J Urol 16:760-4. 2009
    To investigate the regional specificity of multi-channel near infrared spectroscopy (NIRS) on the detection of urination-related cortical activation in healthy men.
  68. ncbi Measurement of cerebral oxygenation in neonates after vaginal delivery and cesarean section using full-spectrum near infrared spectroscopy
    Kenichi Isobe
    Department of Pediatrics Kagawa Medical University, 1750 1 Mikicho, Kitagun, Kagawa 761 0793, Japan
    Comp Biochem Physiol A Mol Integr Physiol 132:133-8. 2002
    ..in cerebral oxygenation, cerebral hemoglobin oxygen saturation was measured using full-spectrum near infrared spectroscopy in 26 healthy term newborn infants immediately after birth...
  69. ncbi Mitochondrial function and oxygen supply in normal and in chronically ischemic muscle: a combined 31P magnetic resonance spectroscopy and near infrared spectroscopy study in vivo
    G J Kemp
    Department of Musculoskeletal Science, University of Liverpool, UK
    J Vasc Surg 34:1103-10. 2001
    ..We used (31)P magnetic resonance spectroscopy (MRS) and near-infrared spectroscopy (NIRS) as a means of quantifying abnormalities in calf muscle oxygenation and adenosine triphosphate (ATP) turnover in peripheral vascular disease (PVD)...
  70. ncbi Steady state redox levels in cytochrome oxidase: relevance for in vivo near infrared spectroscopy (NIRS)
    Chris E Cooper
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester Essex, CO4 3SQ, UK
    Adv Exp Med Biol 645:123-8. 2009
    ..However, it titrated with an apparent redox potential of +230 mV, far from its equilibrium value (+400 mV). The implications of these results for the interpretation of non invasive measurements of mitochondrial function are discussed...
  71. ncbi Oxidation and reduction of cytochrome oxidase in the neonatal brain observed by in vivo near-infrared spectroscopy
    V Quaresima
    Dip Scienze e Tecnologie Biomediche, Universita di L Aquila, Italy
    Biochim Biophys Acta 1366:291-300. 1998
    ....
  72. ncbi Measurement of CMRO2 in neonates undergoing intensive care using near infrared spectroscopy
    Clare E Elwell
    Adv Exp Med Biol 566:263-8. 2005
    ..b>Near infrared spectroscopy (NIRS) is a continuous, non-invasive and portable technique which can be used to measure cerebral blood ..
  73. ncbi Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head
    P G Al-Rawi
    University Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, UK
    Stroke 32:2492-500. 2001
    ..5% and 0%, respectively, and specificity was 100% and 0%, respectively. CONCLUSIONS: The NIRO 300 reflects changes in cerebral tissue oxygenation when TOI is calculated, with a high degree of sensitivity and specificity...
  74. ncbi Combining near infrared spectroscopy and functional MRI during continuous performance test in healthy subjects
    Michele Butti
    Dept of Biomed Eng, Polytech Univ of Milan, Italy
    Conf Proc IEEE Eng Med Biol Soc 1:1944-7. 2006
    ..In this work two imaging techniques are used, the functional magnetic resonance (fMRI) and the near infrared spectroscopy (NIRS), in order to assess cerebral performance during the execution of a well known sustained attention ..
  75. ncbi Changes of cerebral blood oxygenation and optical pathlength during activation and deactivation in the prefrontal cortex measured by time-resolved near infrared spectroscopy
    Kaoru Sakatani
    Department of Neurological Surgery, Nihon University School of Medicine, Japan
    Life Sci 78:2734-41. 2006
    ..simulation in the right and left prefrontal cortex (PFC), employing a newly developed time-resolved near infrared spectroscopy, which allows quantitative measurements of the evoked-CBO changes by determining the MOP with a sampling ..
  76. ncbi Analysis of berberine and total alkaloid content in cortex phellodendri by near infrared spectroscopy (NIRS) compared with high-performance liquid chromatography coupled with ultra-visible spectrometric detection
    Chi On Chan
    State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, PR China
    Anal Chim Acta 592:121-31. 2007
    This paper developed a rapid method using near infrared spectroscopy (NIRS) to differentiate two species of cortex phellodendri (CP), cortex phellodendri chinensis (PCS) and cortex phellodendri amurensis (PAR), and to predict ..
  77. ncbi Near infrared spectroscopy (NIRS) should not be standard of care for postoperative management
    Jennifer C Hirsch
    Department of Surgery, Section of Cardiac Surgery, Division of Pediatric Cardiovascular Surgery, University of Michigan Medical School, Ann Arbor, MI 48109 5864, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 13:51-4. 2010
    Neurologic dysfunction is a problem in patients with congenital heart disease. Near infrared spectroscopy (NIRS) may provide a real-time window into cerebral oxygenation...
  78. ncbi Concordance of near infrared spectroscopy with pressure flow studies in men with lower urinary tract symptoms
    Doreen E Chung
    Department of Urology, Weill Cornell Medical College, New York Presbyterian Hospital, Cornell University, New York, NY, USA
    J Urol 184:2434-9. 2010
    b>Near infrared spectroscopy is a technology with the potential to diagnose bladder outlet obstruction noninvasively...
  79. ncbi Use of visible and near infrared spectroscopy and least squares-support vector machine to determine soluble solids content and pH of cola beverage
    Fei Liu
    College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310029, China
    J Agric Food Chem 55:8883-8. 2007
    ..The results indicated that VIS/NIR spectroscopy combined with LS-SVM could be applied as a rapid and alternative way for the fast determination of SSC and pH of cola beverage...
  80. ncbi Absolute quantification of oxygenated hemoglobin within the visual cortex with functional near infrared spectroscopy (fNIRS)
    Michelle A McIntosh
    Department of Vision Sciences, Glasgow Caledonian University, Glasgow, United Kingdom
    Invest Ophthalmol Vis Sci 51:4856-60. 2010
    ..To examine absolute changes in oxygenated (HbO) and deoxygenated (Hb) hemoglobin concentrations over the visual cortex in response to visual stimulation. Before this study, only relative changes have been reported at the visual cortex...
  81. ncbi Development of a handheld near-infrared imager for dynamic characterization of in vivo biological tissue systems
    Ronald X Xu
    Department of Biomedical Engineering, The Ohio State University, and Division of Surgical Oncology, Arthur G James Cancer Hospital and Richard J Solove Research Institute and Comprehensive Cancer Center, Columbus 43210, USA
    Appl Opt 46:7442-51. 2007
    ....
  82. ncbi Near infrared spectroscopy (NIRS) in children
    Sujata Chakravarti
    Division of Pediatric Cardiology, Mount Sinai Medical Center, New York, NY 10029, USA
    Semin Cardiothorac Vasc Anesth 12:70-9. 2008
    b>Near infrared spectroscopy (NIRS) is a noninvasive method for the in vivo monitoring of tissue oxygenation...
  83. ncbi Pathophysiology of migraine attack with prolonged aura revealed by transcranial Doppler and near infrared spectroscopy
    S Viola
    Department of Neurology, S Pio Hospital, via C De Lellis, 66054, Vasto CH, Italy
    Neurol Sci 31:S165-6. 2010
    ..We studied cortical cerebral microcirculation by an innovative near infrared spectroscopy system (NIRS) and cerebral macrocirculation by transcranial Doppler (TCD) in eight subjects (3 M and 5 F,..
  84. ncbi Near infrared spectroscopy in children at high risk of low perfusion
    Alexander J C Mittnacht
    Department of Anesthesiology, Mount Sinai Medical Center, New York 10029, USA
    Curr Opin Anaesthesiol 23:342-7. 2010
    ..This review summarizes recent developments and available data on the use of near infrared spectroscopy (NIRS) in children at risk for low perfusion.
  85. pmc Carbogen-induced changes in rat mammary tumour oxygenation reported by near infrared spectroscopy
    E L Hull
    Department of Physics and Astronomy, University of Rochester, NY 14627, USA
    Br J Cancer 79:1709-16. 1999
    ..Near infrared diffuse reflectance spectroscopy provides a rapid, non-invasive means of monitoring spatially averaged changes in tumour haemoglobin oxygen saturation induced by oxygen modifiers...
  86. ncbi A study of muscle tissue oxygenation and peripheral microcirculatory dysfunction in cirrhosis using near infrared spectroscopy
    Sam J Thomson
    Department of Gastroenterology and Hepatology, St George s Hospital, London, UK
    Liver Int 30:463-71. 2010
    ..b>Near infrared spectroscopy (NIRS) has been used to assess muscle tissue oxygenation (StO(2)) in haemorrhagic and septic shock...
  87. ncbi Evaluation of placental function using near infrared spectroscopy during fetal growth restriction
    Junichi Hasegawa
    Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan
    J Perinat Med 38:29-32. 2010
    To investigate whether a near infrared spectroscopy (NIRS) system is useful for evaluation of the placental function in cases of fetal growth restriction (FGR).
  88. ncbi A nonfluorescent, broad-range quencher dye for Förster resonance energy transfer assays
    Xinzhan Peng
    LI COR Biosciences, Lincoln, NE 68504, USA
    Anal Biochem 388:220-8. 2009
    ..g., IRDye 700DX, IRDye 680, IRDye 800CW) and the visible fluorophores (e.g., fluorescein, Cy3, Cy5), it should find broad applicability in FRET assays using a wide variety of fluorescent dyes...
  89. ncbi Cerebro-splanchnic oxygenation ratio (CSOR) using near infrared spectroscopy may be able to predict splanchnic ischaemia in neonates
    P M Fortune
    Neonatal Intensive Care Unit, Great Ormond Street Hospital for Children NHS Trust, London WC1 N 3JH, England
    Intensive Care Med 27:1401-7. 2001
    OBJECTIVE: To investigate whether near infrared spectroscopy (NIRS) can detect differences in oxyhaemoglobin signal when applied to the abdomens of neonates with surgically proven splanchnic ischaemia...
  90. ncbi Reproducibility of cerebral near infrared spectroscopy in neonates
    Jan Menke
    Radiodiagnostik, Gebäude 49, Universitäts Kliniken Homburg, D 66424 Homburg, Germany
    Biol Neonate 83:6-11. 2003
    b>Near infrared spectroscopy (NIRS) allows to study cerebral hemodynamics and oxygenation in neonates, which may be useful for early detection of cerebral hypoxemia. So far this method is not reliable enough to be used clinically...
  91. ncbi Characteristic prefrontal blood volume patterns when imaging body type, high-calorie food, and mother-child attachment in childhood anorexia nervosa: A near infrared spectroscopy study
    Shinichiro Nagamitsu
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan
    Brain Dev 32:162-7. 2010
    ..The prefrontal activations during each task, in terms of blood volume changes, were measured by near infrared spectroscopy. Twelve females with childhood AN (mean age, 14...
  92. ncbi Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate
    Woo Kyung Moon
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Bioconjug Chem 14:539-45. 2003
    ..These results indicate that folate-modified NIR fluorochrome conjugate can be used for improved detection of FR-positive tumors...
  93. ncbi Noninvasive monitoring of cerebral oxygenation during vasomotor reactivity tests by a new near-infrared spectroscopy device
    Christoph Terborg
    Department of Neurology, Computer Science and Documentation, University of Jena, Germany
    Cerebrovasc Dis 16:36-41. 2003
    ..Spatially resolved spectroscopy is a recently developed technique for noninvasive monitoring of cerebral tissue oxygenation using the photon diffusion theory...
  94. ncbi Reproducibility of parameters of postocclusive reactive hyperemia measured by near infrared spectroscopy and transcutaneous oximetry
    R Kragelj
    Faculty of Electrical Engineering, University of Ljubljana, Trzaska, Slovenia
    Ann Biomed Eng 28:168-73. 2000
    The purpose of this study was to investigate postocclusive hyperemic response using near infrared spectroscopy (NIRS) and transcutaneous oximetry (TcpO2)...
  95. ncbi Functional near-infrared optical imaging: utility and limitations in human brain mapping
    Yoko Hoshi
    Department of Integrated Neuroscience, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Psychophysiology 40:511-20. 2003
    ....
  96. ncbi Muscle oxygen consumption at onset of exercise by near infrared spectroscopy in humans
    Takafumi Hamaoka
    Department of Preventive Medicine and Public Health, Tokyo Medical University, Japan
    Adv Exp Med Biol 530:475-83. 2003
    In this study, we tried to continuously measure muscle oxygen consumption (m-VO2) by near infrared spectroscopy (NIRS) without arterial occlusions...
  97. ncbi Rapid characterization of biomass using near infrared spectroscopy coupled with multivariate data analysis: Part 1. Yellow-poplar (Liriodendron tulipifera L.)
    Kofi Nkansah
    Division of Forestry and Natural Resources, West Virginia University, Morgantown, WV 26506 6125, USA
    Bioresour Technol 101:4570-6. 2010
    ..The selective spectra region, 1300-1800 nm, included the first and second overtone of the NIR spectrum (1300-1800 nm). Measured and predicted physical and chemical properties of yellow-poplar yielded moderate to high correlation (R2)...
  98. ncbi Near infrared spectroscopy for controlling the quality of distal leg perfusion in remote access cardiopulmonary bypass
    Thomas Schachner
    Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria
    Eur J Cardiothorac Surg 34:1253-4. 2008
    ..b>Near infrared spectroscopy (NIRS) is an established non-invasive method for measuring tissue oxygen saturation...
  99. ncbi Intracerebral hemodynamics probed by near infrared spectroscopy in the transition between wakefulness and sleep
    A J Spielman
    Sleep Disorders Center, Department of Psychology, The City College of the City University of New York, 138th Street and Convent Avenue, New York, NY 10031, USA
    Brain Res 866:313-25. 2000
    ..The current study used the Near Infrared Spectroscopy (NIRS) technique to describe the intracerebral hemodynamics at the frontal pole in the circumscribed ..
  100. ncbi Assessment of cerebral oxygenation during prolonged simulated driving using near infrared spectroscopy: its implications for fatigue development
    Zengyong Li
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, SAR, People s Republic of China
    Eur J Appl Physiol 107:281-7. 2009
    ..Cerebral oxygenation signal was monitored from the left frontal lobe using near infrared spectroscopy throughout the entire experiment...
  101. ncbi Cerebral blood volume changes in patients with eating disorders during word fluency: a preliminary study using multi-channel near infrared spectroscopy
    T Uehara
    Department of Psychiatry and Human Behavior, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371 8511, Japan
    Eat Weight Disord 12:183-90. 2007
    ..This study investigated the characteristics of cerebral oxygenation changes in eating disorders patients (ED) and normal controls during the cognitive tasks, using a highly time-resolved, and non-invasive instrument...

Research Grants66

  1. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..If successful, the health benefit will be large, as it is estimated that treating NEC alone (not including treating its later complications) adds $650 million to the annual health bill. ..
  2. Cerebral metabolism, EEG, and sleep cycling in critically ill neonates
    Renée A Shellhaas; Fiscal Year: 2013
    ..abstract_text> ..
  3. Quantitative Assessment of Oxidative Metabolism in Brown Fat
    Otto Muzik; Fiscal Year: 2011
    ..Moreover, these studies will provide important physiological information about fat metabolism that will likely translate into novel pharmacological approaches for the treatment of obesity. ..
  4. Development of an instrument to track oxygen from blood to mitochondria in vivo
    Kenneth A Schenkman; Fiscal Year: 2013
    ..Evidenced by the explosion of new pulse oximetry and near infrared spectroscopy (NIRS) devices on the market, optical spectroscopy is attractive for noninvasive tissue monitoring in ..
  5. Brain Activation in Humans
    Andrew J Butler; Fiscal Year: 2012
    ..The expecting findings will advance the scientific knowledge of brain connectivity during the resting state using FNIRS for the first time. ..
  6. Attenuated Functional Capacity in Combined Heart Failure &Type 2 Diabetes: ...
    CATHERINE RENEE MIKUS; Fiscal Year: 2013
    ..provide the applicant with the opportunity to learn new laboratory skills including Doppler ultrasound, near infrared spectroscopy, and measures of plasma nitrite flux while refining those needed for the conduct of clinical exercise ..
  7. Effect of Extended-Release Niacin on Saphenous Vein Graft Atherosclerosis
    Emmanouil Brilakis; Fiscal Year: 2013
    ....
  8. Time Resolved Breast Imaging Using a Combined MRI and Optical Tomography Approach
    STEFAN ALEXANDRU CARP; Fiscal Year: 2013
    ..A potential answer may be offered by near infrared spectroscopy and tomography (NIRS-DOT)...
  9. A Multimodality Approach to Estimating Newborn Brain Oxygen Metabolism (CMRO2)
    PATRICIA ELLEN GRANT; Fiscal Year: 2010
    ..We propose to combine Frequency Domain Near Infrared Spectroscopy (FD-NIRS) and the Magnetic Resonance (MR) technique of Arterial Spin Labeling (ASL) to estimate newborn ..
  10. Prasugrel for prevention of early saphenous vein graft thrombosis
    Emmanouil Brilakis; Fiscal Year: 2013
    ....
  11. Integrated EEG/NIR Sensor System for Infants
    Catherine Poulsen; Fiscal Year: 2013
    ..Finally, commercial user guides for hardware, acquisition software, and analysis software will be prepared to accompany the dEEG/NIRS acquisition and analysis product. ..
  12. Noninvasive, Optoacoustic Monitoring of Cerebral Circulation in Preterm Neonates
    GRAHAM RANDALL; Fiscal Year: 2013
    ..Specific Aim 3. Preliminarily establish in vivo in neonates the range of SSSSO2 to be expected in infants of varying body weight (10-12 LBW neonates and 10-12 VLBW neonates). ..
  13. Design Optimization of Combined Magnetoencephalography and Susceptometry
    Solomon Gilbert Diamond; Fiscal Year: 2013
    ..1 ..
  14. REVIVE - Resveratrol to enhance vitality and vigor in elders
    Stephen D Anton; Fiscal Year: 2013
    ..at a dose of 1000 mg/day, significantly enhanced resting muscle oxidative metabolism (measured using near infrared spectroscopy), as well as cognitive and physical function, in older adults (age >65 years)...
  15. Neuroprotection with serpins during cardiac surgery
    Richard A Jonas; Fiscal Year: 2010
    ..Adequacy of cerebral oxygen delivery will be monitored by near infrared spectroscopy. Several dosage levels of aprotinin will be employed to determine optimal dose...
  16. Cerebral Autoregulation Monitoring to Reduce Brain Injury from Cardiac Surgery
    OLA ARVID SELNES; Fiscal Year: 2013
    ..the middle cerebral artery measured with transcranial Doppler and with cerebral oximetry measured with near infrared spectroscopy. The primary end-point of the study will be a comprehensive composite outcome of clinical stroke, ..
  17. Merging Diffuse Optical Tomography with EEG, MEG and MRI for Neurovascular Exams
    Solomon Gilbert Diamond; Fiscal Year: 2010
    ..Research on the neurovascular relationship will ultimately have long-term benefits to understanding the aging brain and diagnosing neurological diseases. ..
  18. Mechanisms and Meanings of Impaired Microvascular Responses in Human Sepsis
    Kevin C Doerschug; Fiscal Year: 2013
    ..We will use Near Infrared Spectroscopy (NIRS) to measure microvascular responses to ischemia, and strengthen our findings with sublingual ..
  19. Biological and neural mechanisms of falls
    Joe Verghese; Fiscal Year: 2013
    ..3). Establish the contribution of the prefrontal cortex to falls using an innovative functional near infrared spectroscopy (fNIRS), that enables imaging during walking...
  20. Monitoring Brain Health in Neonatal Congenital Heart Disease with Bedside CMR02
    PATRICIA ELLEN GRANT; Fiscal Year: 2013
    ..monitoring for acute hypoxic ischemic brain injury is performed with bedside continuous wave near infrared spectroscopy (CWNIRS) measures of frontal brain relative tissue oxygen saturation (rStO2)...
  21. Neurodevelopmental Outcome after Cardiac Intensive Care
    DAVID LLOYD WESSEL; Fiscal Year: 2013
    ..The broad objective of this concept proposal is to demonstrate that near infrared spectroscopy (NIRS) cerebral tissue oxygenation index (TOI) will identify significant cerebral ischemia and provide ..
  22. Goal-directed Resuscitative Interventions during Pediatric Inter-facility Transpo
    MICHAEL HUGH STROUD; Fiscal Year: 2011
    ..This study has the potential to change the current practice of pediatric inter-facility transport, and improve clinical outcomes of pediatric SIRS. ..
  23. Optical monitoring of cerebral oxygenation in infants
    Maria Angela Franceschini; Fiscal Year: 2012
    ....
  24. Near-Infrared Spectroscopy for Pediatric Acute Scrotum and Testicular Torsion
    Linda A Baker; Fiscal Year: 2013
    ....
  25. Optimal neural and behavioral markers for learning to learn during infancy
    Rachel Wu; Fiscal Year: 2013
    ..This work will contribute to a foundational understanding of the dynamics of selective attention and learning in typical development, which in turn would inform populations with learning difficulties. ..
  26. The Development and Neural Bases of Emotion Processing
    CHARLES ALEXANDER NELSON; Fiscal Year: 2013
    ..autonomic activity (skin conductance and pupil diameter) will be recorded in conjunction with functional Near Infrared Spectroscopy (fNIRS)...
  27. Cerebrovascular Dysfunction in Newborns with HIE during Hypothermia and Rewarming
    Lina F Chalak; Fiscal Year: 2013
    ..To achieve this goal, state-of-the-art noninvasive near infrared spectroscopy (NIRS) and transcranial Doppler will be used to measure cerebral autoregulation and cerebral tissue ..
  28. Brain Imaging plus Urodynamics to Investigate the Brain's Control of the Bladder
    Werner Schaefer; Fiscal Year: 2012
    ..It also could facilitate development of more effective behavioral interventions for both UUI and OAB. ..
  29. Quantitation of Insult and Injury to the Preterm Brain
    ADRE JACQUES DU PLESSIS; Fiscal Year: 2011
    ..function analysis of continuously measured changes in blood pressure and cerebral perfusion (using near infrared spectroscopy;NIRS) will identify significant periods of pressure-passive cerebral perfusion preceding germinal matrix-..
  30. Objective Pain Measures in Awake Sedated, Anesthetized Individuals with NIRS
    David Borsook; Fiscal Year: 2013
    ..Over the past few years we have developed the use of Near Infrared Spectroscopy (NIRS) to provide an objective measure of pain sensation...
  31. Evaluation of cartilage tissue engineering strategies by IR imaging
    Nancy Pleshko; Fiscal Year: 2012
    ..In contrast, near infrared spectroscopy (NIRS), a technique also based on molecular vibrations, utilizes higher frequency radiation that can ..
  32. Realtime Near Infrared Spectroscopy of the Frontal Lobe for Neurofeedback
    BLAISE DEBONNEVAL FREDERICK; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): This R21 proposal will develop and validate a real-time near infrared spectroscopy (NIRS) imaging system that will allow subjects to monitor their own frontal brain activity, as it happens, in order ..
  33. Predictors of recovery from intracerebral hemorrhage in children
    LORI CHAFFIN JORDAN; Fiscal Year: 2012
    ..COx is measured non-invasively by near infrared spectroscopy (NIRS) and arterial blood pressure...
  34. Neuroimaging of the Development of Neural Mechanisms Social Cognition
    Kevin A Pelphrey; Fiscal Year: 2010
    ..A successful demonstration of the usefulness of fNIRS would open new lines of research into how children's brains develop to function in a social world. ..
  35. Augmented Physiologic Monitoring to Predict Brain Injury in Infants with CHD
    DANIEL JACQUES LICHT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Novel non-invasive optical instrumentation including near infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS) increase our ability to measure cerebral hemodynamics and oxygenation ..
  36. Central Control of Mobility in Aging
    Roee Holtzer; Fiscal Year: 2013
    ..Functional Near Infrared Spectroscopy (FNIRS) will be used in each study visit to identify in motion PFC functional correlates of mobility (..
  37. Vibrational Photoacoustic Microscopy for Bond-selective Tissue Analysis
    Ji Xin Cheng; Fiscal Year: 2011
    ..Successful development of an intravascular vibrational photoacoustic probe holds the potential of detecting vulnerable plaques in a label free manner. ..
  38. Multi-modal Neuroimaging Training Program
    Peter J Gianaros; Fiscal Year: 2013
    ..This will speed up the synergistic application of multiple imaging modalities to basic and clinical neuroscience research in animals and humans. ..
  39. Multi-modal Neuroimaging Training Program
    Peter J Gianaros; Fiscal Year: 2013
    ..This will speed up the synergistic application of multiple imaging modalities to basic and clinical neuroscience research in animals and humans. ..
  40. Computational Optical Tomography for Anti-stroke Therapy (R21/R33)
    Hanli Liu; Fiscal Year: 2009
    ..for 3D tomographic imaging of vascular oxygenation obtained by combining DOT, CGD measurements, and the near infrared spectroscopy (NIRS)...
  41. Experimentally Testing the Effect of Parent-Adolescent Conflict on HIV Risk
    Sarah Ann Thomas; Fiscal Year: 2013
    ....
  42. Self-regulatory Control and Eating: A Neuroimaging Study of Bulimia Nervosa
    Laura A Berner; Fiscal Year: 2013
    ....
  43. Computational method to improve signal detection in NIRS instruments
    Andrei V Medvedev; Fiscal Year: 2011
    ..With increased sensitivity and selectivity, the NIRS technology will find numerous applications in the basic research as well as clinical studies of many types of pathology in a bedside setting. ..
  44. Computational method to improve signal detection in NIRS instruments
    Andrei V Medvedev; Fiscal Year: 2012
    ..With increased sensitivity and selectivity, the NIRS technology will find numerous applications in the basic research as well as clinical studies of many types of pathology in a bedside setting. ..
  45. CEREBROVASCULAR RESERVE BY XE/CT VERSUS TCD AND OXIMETRY
    Ronda Pindzola; Fiscal Year: 2003
    ..The purpose of this study is to define the relationship between Xe/CT CBF and TCD and near infrared spectroscopy (NIRS) measurements in order to best identify the patients with compromised cerebrovascular reserves...
  46. High resolution functional MRI of columnar structures
    Ravi Menon; Fiscal Year: 2007
    ..The concentrations of oxyhemoglobin [HbO] and deoxyhemoglobin [Hbr] will also be measured using NIR spectroscopy (NIRS). Blood flow will be measured using a commercial fiber optic laser Doppler flow system (Oxyflow, Oxford Optronix). ..
  47. Vibrational Photoacoustic Microscopy for Bond-selective Tissue Analysis
    Ji Xin Cheng; Fiscal Year: 2013
    ..Furthermore, our endoscopy development is expected to push the VPA method towards intravital imaging of plaques. ..
  48. CLINICAL TRIAL OF HEMATOCRIT STRATEGY IN HEART SURGERY
    Jane Newburger; Fiscal Year: 2004
    ..as a measure of cerebral cellular injury; 2) cerebral hemodynamics and oxygenation, determined by near infrared spectroscopy (NIRS); 3) intrinsic cerebral vasoregulation, measured by NIRS and transcranial Doppler; and 4) at age 1 ..
  49. Integrated EEG/NIR Sensor System for Infants
    Catherine Poulsen; Fiscal Year: 2009
    ..Such early identification is vital to the development of early interventions that may mitigate or even preclude the emergence of the disorder. ..
  50. Neural correlates of lexical processing in child L2 learners
    Arturo E Hernandez; Fiscal Year: 2010
    ..To achieve this, the proposed project will use Near Infrared Spectroscopy (NIRS), which measures neural activity indirectly via changes in deoxyhemoglobin and hemoglobin which is ..
  51. Multimodal Neuroimaging of Cigarette Smoking
    Yunjie Tong; Fiscal Year: 2013
    ..The proposed mentored training plan will assist the applicant to become an independent investigator developing and applying new imaging techniques and analytical tools to study substance abuse. ..
  52. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 2003
    ..blood flow velocity in-utero and after birth; 2) altered cerebral oxygen availability as measured by near infrared spectroscopy (NIRS) after birth; and 3) elevated serum concentrations of IL-1beta, IL-6, and TNF-alpha which can be ..
  53. Development of near-infrared spectroscopy to study drug addiction
    BLAISE DEBONNEVAL FREDERICK; Fiscal Year: 2013
    ..Aims Proposed: * Specific Aim 1. To establish the similarities in blood flow changes detected by fMRI and NIRS. * Specific Aim II: To determine whether we can use NIRS to monitor neuronal activity in real-time in freely moving animals. ..
  54. Training in Drug Abuse and Brain Imaging
    Scott E Lukas; Fiscal Year: 2013
    ..Sophisticated MRI, PET, EEG and Near Infrared Spectroscopy (NIRS) techniques can be used to explore the neurobiological bases of drug abuse and dependence...
  55. NIRS Optical Topography System - Hitachi ETG-4000
    Allan Reiss; Fiscal Year: 2007
    ..Instrumentation Grant Program (S10) is to bring to the research community at Stanford University a near infrared spectroscopy (NIRS) system to perform cutting-edge cognitive and clinical neuroscience research...
  56. MATERNAL ANESTHESIA AND FETAL CEREBRAL OXYGENATION
    James Reynolds; Fiscal Year: 2003
    ..To that end, we are developing a means (near infrared spectroscopy; NIRS) of continually measuring in utero fetal cerebral oxygenation in pregnant sheep...
  57. Optical Imaging in Infants
    TERESA G WILCOX; Fiscal Year: 2013
    ..abstract_text> ..
  58. NIRFAST
    Brian W Pogue; Fiscal Year: 2012
    ..The project will develop this, and allow multicenter collaboration on a study to show that it can be integrated into existing Magnetic resonance imaging systems. ..
  59. ESTROGEN/SYMPATHETIC VASOCONSTRICTION IN SKELETAL MUSCLE
    Gail Thomas; Fiscal Year: 2003
    ..In anesthetized female rats, she will measure hindlimb blood flow and muscle oxygenation with near infrared spectroscopy to determine if functional sympatholysis is attenuated in states of estrogen-deficiency such as sexual ..
  60. fNIRS System to Further Research on Neurodevelopmental Disorders
    Kevin A Pelphrey; Fiscal Year: 2010
    ..This proposal seeks support to acquire a state-of-the-art Hitachi Medical Systems ETG-4000 functional near infrared spectroscopy (fNIRS) multi-channel optical topography system for the study of the brain systems underpinning various ..
  61. Functional near-infrared imaging using the phase of hemodynamic oscillations
    Angelo Sassaroli; Fiscal Year: 2012
    ..This project can lead to a novel approach to functional brain studies, and explores signals that are not accessible with functional magnetic resonance imaging, involving both paramagnetic and diamagnetic hemoglobin species. ..
  62. ABSOLUTE NEAR-INFRARED BRAIN OXIMETER
    Antonios Michalos; Fiscal Year: 2000
    ..and, (c.) by the surgeon for monitoring brain oxygenation during open-heart surgery. ..
  63. PHYSIOLOGIC BASIS OF MUSCLE FUNCTIONAL MRI
    RONALD MEYER; Fiscal Year: 2005
    ..with transient changes in vessel blood flow (MRI and Doppler ultrasound) and hemoglobin saturation (near infrared spectroscopy, NIRS) in healthy subjects...
  64. CEREBROVASCULAR HEMODYNAMICS IN PRETERM BRAIN INJURY
    TIMOTHY WATKINS; Fiscal Year: 2001
    ..Oscillations of cerebral blood flow will be detected and quantified by near Infrared spectroscopy. Specific Aim number 1: Arterial baroreflex...
  65. Combined Breast Tomosynthesis and Near Infrared Spectroscopy for Cancer Detection
    Kelly Michaelsen; Fiscal Year: 2013
    ....
  66. CHARACTERISTICS OF PERFUSION RELATED CORTICAL SIGNALS
    Arthur Toga; Fiscal Year: 2007
    ..proposal is to investigate perfusion related signals measured using Optical Intrinsic Signals (OIS), Near Infrared Spectroscopy (NIRS), functional Magnetic Resonance Imaging (fMRI) and Electroencephalography (EEG) during a variety ..