stroke volume

Summary

Summary: The amount of BLOOD pumped out of the HEART per beat not to be confused with cardiac output (volume/time).

Top Publications

  1. ncbi Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiograph
    Roberto M Lang
    University of Chicago Hospitals, Chicago, IL, USA
    J Am Soc Echocardiogr 18:1440-63. 2005
  2. ncbi Recommendations for chamber quantification
    Roberto M Lang
    Med Klinik 2, Erlangen University, Ulmenweg 18, 91054 Erlangen, Germany
    Eur J Echocardiogr 7:79-108. 2006
  3. ncbi Trends in prevalence and outcome of heart failure with preserved ejection fraction
    Theophilus E Owan
    Cardiorenal Research Laboratory, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    N Engl J Med 355:251-9. 2006
  4. ncbi How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
    Walter J Paulus
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
    Eur Heart J 28:2539-50. 2007
  5. ncbi Outcome of heart failure with preserved ejection fraction in a population-based study
    R Sacha Bhatia
    Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, and the Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada
    N Engl J Med 355:260-9. 2006
  6. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
  7. ncbi The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
  8. ncbi Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
    Birgit Assmus
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 106:3009-17. 2002
  9. ncbi Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
    Salim Yusuf
    McMaster Clinic, Room 252, Hamilton General Hospital, 237 Barton Street East, ON, L8L 2X2, Hamilton, Canada
    Lancet 362:777-81. 2003
  10. ncbi Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur Heart J 28:1250-7. 2007

Detail Information

Publications307 found, 100 shown here

  1. ncbi Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiograph
    Roberto M Lang
    University of Chicago Hospitals, Chicago, IL, USA
    J Am Soc Echocardiogr 18:1440-63. 2005
  2. ncbi Recommendations for chamber quantification
    Roberto M Lang
    Med Klinik 2, Erlangen University, Ulmenweg 18, 91054 Erlangen, Germany
    Eur J Echocardiogr 7:79-108. 2006
    ..This document reviews the technical aspects on how to perform quantitative chamber measurements of morphology and function, which is a component of every complete echocardiographic examination...
  3. ncbi Trends in prevalence and outcome of heart failure with preserved ejection fraction
    Theophilus E Owan
    Cardiorenal Research Laboratory, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    N Engl J Med 355:251-9. 2006
    ..We performed a study to define secular trends in the prevalence of heart failure with preserved ejection fraction among patients at a single institution over a 15-year period...
  4. ncbi How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
    Walter J Paulus
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
    Eur Heart J 28:2539-50. 2007
    ..The updated strategies for the diagnosis and exclusion of HFNEF are useful not only for individual patient management but also for patient recruitment in future clinical trials exploring therapies for HFNEF...
  5. ncbi Outcome of heart failure with preserved ejection fraction in a population-based study
    R Sacha Bhatia
    Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, and the Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada
    N Engl J Med 355:260-9. 2006
    ....
  6. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  7. ncbi The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
    ..We evaluated its effects on morbidity and mortality...
  8. ncbi Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
    Birgit Assmus
    Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany
    Circulation 106:3009-17. 2002
    ..The safety and feasibility of autologous progenitor cell transplantation in patients with ischemic heart disease is unknown...
  9. ncbi Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
    Salim Yusuf
    McMaster Clinic, Room 252, Hamilton General Hospital, 237 Barton Street East, ON, L8L 2X2, Hamilton, Canada
    Lancet 362:777-81. 2003
    ..We investigated the effect of addition of an angiotensin-receptor blocker to current treatments...
  10. ncbi Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur Heart J 28:1250-7. 2007
    ..This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH)...
  11. ncbi Cardiac-resynchronization therapy for the prevention of heart-failure events
    Arthur J Moss
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    N Engl J Med 361:1329-38. 2009
    ....
  12. pmc Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]
    Rupert Pearse
    Adult Intensive Care Unit, St George s Hospital, Blackshaw Road, London SW17 0QT, UK
    Crit Care 9:R687-93. 2005
    ..The aim of this study was to evaluate the effect of post-operative GDT on the incidence of complications and duration of hospital stay in patients undergoing general surgery...
  13. ncbi Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden
    Teresa S M Tsang
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Cardiol 90:1284-9. 2002
    ..In patients without a history of atrial arrhythmias or valvular heart disease, LA volume expressed the severity of diastolic dysfunction and provided an index of cardiovascular risk and disease burden...
  14. ncbi Irbesartan in patients with heart failure and preserved ejection fraction
    Barry M Massie
    University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco 94121, USA
    N Engl J Med 359:2456-67. 2008
    ..Therefore, we studied the effects of irbesartan in patients with this syndrome...
  15. pmc Percent emphysema, airflow obstruction, and impaired left ventricular filling
    R Graham Barr
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    N Engl J Med 362:217-27. 2010
    ..pulmonale with elevated pulmonary vascular resistance and secondary reductions in left ventricular filling, stroke volume, and cardiac output...
  16. ncbi Effect of posterolateral scar tissue on clinical and echocardiographic improvement after cardiac resynchronization therapy
    Gabe B Bleeker
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Circulation 113:969-76. 2006
    ..In the present study, the relationship between transmural posterolateral scar tissue and response to CRT was evaluated...
  17. ncbi Prediction of all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring
    Tony Stanton
    School of Medicine, University of Queensland, Brisbane, Australia
    Circ Cardiovasc Imaging 2:356-64. 2009
    ..The aim of this study was to compare global longitudinal speckle strain (GLS), an automated technique for measurement of long-axis function, with EF and WMSI for the prediction of mortality...
  18. ncbi Prognostic value of routine cardiac magnetic resonance assessment of left ventricular ejection fraction and myocardial damage: an international, multicenter study
    Igor Klem
    Duke University Medical Center, Durham, NC, USA
    Circ Cardiovasc Imaging 4:610-9. 2011
    ..We performed an international, multicenter study to assess the prognostic importance of routine CMR in patients with known or suspected heart disease...
  19. ncbi Sildenafil treatment in COPD does not affect stroke volume or exercise capacity
    H Rietema
    Dept of Pulmonary Diseases and Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur Respir J 31:759-64. 2008
    In chronic obstructive pulmonary disease (COPD) patients, stroke volume response to exercise is impaired...
  20. ncbi Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus
    Luuk J Rijzewijk
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 52:1793-9. 2008
    ....
  21. ncbi The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy
    James C C Moon
    Centre for Advanced Magnetic Resonance in Cardiology CAMRIC, London, United Kingdom
    J Am Coll Cardiol 43:2260-4. 2004
    ..We sought to identify the histologic basis of myocardial late gadolinium enhancement cardiovascular magnetic resonance (CMR) in hypertrophic cardiomyopathy (HCM)...
  22. ncbi Systolic and diastolic heart failure in the community
    Francesca Bursi
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    JAMA 296:2209-16. 2006
    ..Further, diastolic function is seldom systematically assessed based on standardized techniques...
  23. ncbi Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery
    H G Wakeling
    Department of Anaesthesia, Worthing Hospital, Lyndhurst Road, Worthing BN11 2DH, UK
    Br J Anaesth 95:634-42. 2005
    ..We assessed whether using intraoperative oesophageal Doppler guided fluid management to minimize hypovolaemia would reduce postoperative hospital stay and the time before return of gut function after colorectal surgery...
  24. ncbi Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction
    Stefan H Hohnloser
    Department of Medicine, Division of Cardiology, J W Goethe University, Frankfurt, Germany
    N Engl J Med 351:2481-8. 2004
    ..Whether benefit occurs in patients early after myocardial infarction is unknown...
  25. ncbi Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects
    Anand Kumar
    Division of Cardiovascular Disease and Critical Care Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Crit Care Med 32:691-9. 2004
    ....
  26. ncbi Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle
    Michael R Zile
    Cardiology Division, Department of Medicine, Gazes Cardiac Research Institute, Medical University of South Carolina, Charleston 29425, USA
    N Engl J Med 350:1953-9. 2004
    ..It has traditionally been thought that the pathophysiological cause of heart failure in these patients is an abnormality in the diastolic properties of the left ventricle; however, this hypothesis remains largely unproven...
  27. ncbi Prevalence of left-ventricular systolic dysfunction and heart failure in the Echocardiographic Heart of England Screening study: a population based study
    M Davies
    Department of Cardiology, Selly Oak Hospital, Raddlebarn Road, Selly Oak, West Midlands, UK
    Lancet 358:439-44. 2001
    ..Our results suggest that assessment of left-ventricular function in patients with suspected heart failure could lead to more effective diagnosis and treatment of this disorder...
  28. ncbi Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    Lazaros A Nikolaidis
    Cardiovascular Research Institute, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Circulation 109:962-5. 2004
    ..Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with both insulinotropic and insulinomimetic properties that stimulate glucose uptake without the requirements for concomitant glucose infusion...
  29. ncbi Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study
    Finlay A McAlister
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Circulation 109:1004-9. 2004
    ..The prevalence, prognostic import, and impact of renal insufficiency on the benefits of ACE inhibitors and beta-blockers in community-dwelling patients with heart failure are uncertain...
  30. pmc Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction
    Ellen O Weinberg
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Mass 02139, USA
    Circulation 106:2961-6. 2002
    ..We identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes and hypothesized that ST2 participates in the acute myocardial response to stress and injury...
  31. pmc Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator implantation
    Igor Klem
    Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, NC 27710, USA
    J Am Coll Cardiol 60:408-20. 2012
    ..We tested whether an assessment of myocardial scarring by cardiac magnetic resonance imaging (MRI) would improve risk stratification in patients evaluated for implantable cardioverter-defibrillator (ICD) implantation...
  32. ncbi Reference right ventricular systolic and diastolic function normalized to age, gender and body surface area from steady-state free precession cardiovascular magnetic resonance
    Alicia M Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Heart J 27:2879-88. 2006
    ..We used these techniques to establish the reference values for right ventricular (RV) volumes and function...
  33. ncbi Renal function as a predictor of outcome in a broad spectrum of patients with heart failure
    Hans L Hillege
    Medical Center Groningen, University of Groningen, The Netherlands
    Circulation 113:671-8. 2006
    ..The aim of this analysis was to evaluate the prognostic importance of renal function in a broader spectrum of patients with CHF...
  34. pmc Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study
    Jan Benes
    Department of Anesthesiology and Intensive Care, Charles University Teaching Hospital, Alej Svobody 80, Plzen 304 60, Czech Republic
    Crit Care 14:R118. 2010
    b>Stroke volume variation (SVV) is a good and easily obtainable predictor of fluid responsiveness, which can be used to guide fluid therapy in mechanically ventilated patients...
  35. ncbi Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 117:43-51. 2008
    ..The contribution to diastolic stiffness of fibrosis, AGEs, and cardiomyocyte resting tension was assessed in diabetic heart failure patients with normal or reduced LVEF...
  36. ncbi Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure
    Martin G St John Sutton
    Division of Cardiology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Circulation 107:1985-90. 2003
    ..The purpose of the present study was to determine whether improvements in left ventricular (LV) size and function were associated with CRT...
  37. pmc Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system
    Slava Epelman
    Department of Internal Medicine, Heart and Vascular Institute, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 52:750-4. 2008
    ..We sought to determine whether circulating soluble angiotensin-converting enzyme 2 (sACE2) is increased in the plasma of patients with heart failure (HF)...
  38. ncbi Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction
    Umesh C Sharma
    Experimental and Molecular Cardiology Laboratory, Department of Cardiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht, The Netherlands
    Circulation 110:3121-8. 2004
    ..However, it is unclear whether such mechanisms are already activated when hypertrophied hearts still appear well-compensated and whether such early mechanisms contribute to the development of HF...
  39. ncbi Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure
    S Ghio
    Dipartimento di Cardiologia, IRCCS Policlinico S Matteo, Pavia, Italy
    J Am Coll Cardiol 37:183-8. 2001
    ..We sought a better understanding of the coupling between right ventricular ejection fraction (RVEF) and pulmonary artery pressure (PAP), as it might improve the accuracy of the prognostic stratification of patients with heart failure...
  40. ncbi Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index: prospective cohort study
    E Wu
    Feinberg Cardiovascular Research Institute, Division of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, 201 East Huron, Galter 10 240, Chicago, IL 60611 2908, USA
    Heart 94:730-6. 2008
    ..We sought to assess the relative impact of infarct size, EF and ESVI on clinical outcomes and left ventricular (LV) remodelling...
  41. ncbi Novel speckle-tracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy
    Matthew S Suffoletto
    The Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    Circulation 113:960-8. 2006
    ..Mechanical dyssynchrony is a potential means to predict response to cardiac resynchronization therapy (CRT). We hypothesized that novel echocardiographic image speckle tracking can quantify dyssynchrony and predict response to CRT...
  42. pmc Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy
    Kenneth C Bilchick
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    JACC Cardiovasc Imaging 1:561-8. 2008
    ....
  43. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
    ....
  44. ncbi Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure
    Gust H Bardy
    Seattle Institute for Cardiac Research, Seattle, WA 98103, USA
    N Engl J Med 352:225-37. 2005
    ..Treatment with amiodarone or an implantable cardioverter-defibrillator (ICD) has been proposed to improve the prognosis in such patients...
  45. ncbi Cardiovascular magnetic resonance in cardiac amyloidosis
    Alicia Maria Maceira
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK
    Circulation 111:186-93. 2005
    ..Cardiac amyloidosis can be diagnostically challenging. Cardiovascular magnetic resonance (CMR) can assess abnormal myocardial interstitium...
  46. ncbi Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence
    Frederic Michard
    Medical ICU, CHU de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, Universite Paris XI, France
    Chest 121:2000-8. 2002
    ..To identify and critically review the published peer-reviewed, English-language studies investigating predictive factors of fluid responsiveness in ICU patients...
  47. ncbi Doppler myocardial imaging to evaluate the effectiveness of pacing sites in patients receiving biventricular pacing
    Gerardo Ansalone
    Department of Heart Diseases, San Filippo Neri Hospital, Rome, Italy
    J Am Coll Cardiol 39:489-99. 2002
    ..The goal of this study was to compare the efficacy of biventricular pacing (BIV) at the most delayed wall of the left ventricle (LV) and at other LV walls...
  48. ncbi Functional recovery after acute myocardial infarction: comparison between angiography, electrocardiography, and cardiovascular magnetic resonance measures of microvascular injury
    Robin Nijveldt
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 52:181-9. 2008
    ....
  49. ncbi Impact of systolic time intervals on the relationship between arterial stiffness and left ventricular hypertrophy
    Ho Ming Su
    Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan
    Atherosclerosis 223:171-6. 2012
    ....
  50. ncbi The hibernating myocardium: current concepts, diagnostic dilemmas, and clinical challenges in the post-STICH era
    Benoy Nalin Shah
    Department of Cardiology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Eur Heart J 34:1323-36. 2013
    ..Finally, we have suggested a possible methodology for an 'ideal trial' designed to evaluate the role of revascularization in such patients and also explored how viability testing should be used in clinical practice in the post-STICH era...
  51. ncbi Noninvasive single-beat determination of left ventricular end-systolic elastance in humans
    C H Chen
    Division of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan, Taiwan
    J Am Coll Cardiol 38:2028-34. 2001
    ..a modified single-beat method employing systolic (P(s)) and diastolic (P(d)) arm-cuff pressures, echo-Doppler stroke volume (SV), echo-derived ejection fraction (EF) and an estimated normalized ventricular elastance at arterial end-..
  52. ncbi Short- and long-term outcomes of intracoronary and endogenously mobilized bone marrow stem cells in the treatment of ST-segment elevation myocardial infarction: a meta-analysis of randomized control trials
    Hendrik Zimmet
    Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, 99 Commercial Rd, Melbourne, VIC 3004, Australia
    Eur J Heart Fail 14:91-105. 2012
    ..Studies have provided conflicting results. We therefore performed a meta-analysis of these treatments, examining short- and long-term efficacy and safety...
  53. pmc Comprehensive cardiovascular magnetic resonance of myocardial mechanics in mice using three-dimensional cine DENSE
    Xiaodong Zhong
    MR R and D Collaborations, Siemens Healthcare, Atlanta, USA
    J Cardiovasc Magn Reson 13:83. 2011
    ..Quantitative noninvasive imaging of myocardial mechanics in mice enables studies of the roles of individual genes in cardiac function. We sought to develop comprehensive three-dimensional methods for imaging myocardial mechanics in mice...
  54. pmc Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community
    Jennifer E Ho
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702, USA
    J Am Coll Cardiol 60:1249-56. 2012
    ..The aim of this study was to examine the relation of galectin-3 (Gal-3), a marker of cardiac fibrosis, with incident heart failure (HF) in the community...
  55. ncbi The limit of plausibility for predictors of response: application to biventricular pacing
    Sukhjinder S Nijjer
    Department of Cardiology, Hammersmith Hospital, London, UK
    JACC Cardiovasc Imaging 5:1046-65. 2012
    ..We then apply this to echocardiographic measurements of mechanical dyssynchrony and response...
  56. ncbi Alterations of left ventricular myocardial characteristics associated with obesity
    Chiew Y Wong
    University of Queensland, Brisbane, Australia
    Circulation 110:3081-7. 2004
    ..We sought whether body mass index (BMI) and insulin levels were associated with subclinical myocardial disturbances...
  57. pmc Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: a Doppler Tissue and Speckle Tracking echocardiography study
    Sebastian Schattke
    Universitatsmedizin Berlin, Medical Clinic for Cardiology and Angiology, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Cardiovasc Ultrasound 8:3. 2010
    ..The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV) systolic dysfunction in patients with systemic sclerosis (SSc) without pulmonary hypertension...
  58. ncbi Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction
    Ketil Lunde
    Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    N Engl J Med 355:1199-209. 2006
    ..We designed a randomized, controlled trial to further investigate the effects of this treatment...
  59. ncbi Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    N Engl J Med 346:877-83. 2002
    ..This randomized trial was designed to evaluate the effect of an implantable defibrillator on survival in such patients...
  60. ncbi Agreement between methods of measurement with multiple observations per individual
    J Martin Bland
    Department of Health Sciences, University of York, York, UK
    J Biopharm Stat 17:571-82. 2007
    ..In this paper we describe methods for analysing such clustered observations, both when the underlying quantity is assumed to be changing and when it is not...
  61. ncbi Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis
    Kan N Hor
    Department of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    JACC Cardiovasc Imaging 3:144-51. 2010
    ....
  62. ncbi Using extracorporeal life support to resuscitate adult postcardiotomy cardiogenic shock: treatment strategies and predictors of short-term and midterm survival
    Meng Yu Wu
    Department of Cardiovascular Surgery, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
    Resuscitation 81:1111-6. 2010
    ..Postcardiotomy extracorporeal life support (ECLS) is a resource-demanding therapy with varied results among institutions. An organized protocol was necessary to improve the effectiveness of this therapy...
  63. ncbi Prediction of fluid responsiveness in septic shock patients: comparing stroke volume variation by FloTrac/Vigileo and automated pulse pressure variation
    Bodin Khwannimit
    Division of Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Eur J Anaesthesiol 29:64-9. 2012
    The aim of this study was to assess and compare the ability of the automatically and continuously measured stroke volume variation (SVV) obtained by FloTrac/Vigileo, and pulse pressure variation (PPV) measured by an IntelliVue MP monitor,..
  64. ncbi Comparison of myocardial infarct size assessed with contrast-enhanced magnetic resonance imaging and left ventricular function and volumes to predict mortality in patients with healed myocardial infarction
    Stijntje D Roes
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 100:930-6. 2007
    ..In conclusion, infarct size on contrast-enhanced MRI may be superior to LVEF and LV volumes for predicting long-term mortality in patients with healed myocardial infarction...
  65. ncbi Effect of perindopril on the onset and progression of left ventricular dysfunction in Duchenne muscular dystrophy
    Denis Duboc
    French Working Group of Heart Involvement in Myopathies Investigators, Paris, France
    J Am Coll Cardiol 45:855-7. 2005
    ..The aim of this research was to examine the effects of perindopril on cardiac function in patients with Duchenne muscular dystrophy (DMD)...
  66. ncbi Left ventricular volume measurement with echocardiography: a comparison of left ventricular opacification, three-dimensional echocardiography, or both with magnetic resonance imaging
    Carly Jenkins
    Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Eur Heart J 30:98-106. 2009
    ..We sought to examine the accuracy of non-contrast (NC) and CE-2DE and 3DE for calculation of LV volumes and ejection fraction (EF), relative to cardiac magnetic resonance imaging (MRI)...
  67. ncbi Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction
    Mario Kasner
    Department of Cardiology and Pneumology, Campus Benjamin Franklin, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Am Coll Cardiol 57:977-85. 2011
    ..We attempted to correlate echocardiographic analysis of diastolic function with changes of myocardial collagen in middle-aged patients with heart failure (HF) despite normal ejection fraction (EF)...
  68. ncbi Comparison of a non-invasive arterial pulse contour technique and echo Doppler aorta velocity-time integral on stroke volume changes in optimization of cardiac resynchronization therapy
    Irene E van Geldorp
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Europace 13:87-95. 2011
    ..the accuracy and feasibility of a non-invasive arterial pulse contour technique for continuous measurement of stroke volume (SV) in optimization of atrioventricular (AV) delay in cardiac resynchronization therapy (CRT), by comparing ..
  69. ncbi Accuracy of stroke volume variation in predicting fluid responsiveness: a systematic review and meta-analysis
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Central Hospital, 351 Mingyue Road, Jinhua, 321000, Zhejiang, People s Republic of China
    J Anesth 25:904-16. 2011
    b>Stroke volume variation (SVV) appears to be a good predictor of fluid responsiveness in critically ill patients. However, a wide range of its predictive values has been reported in recent years...
  70. pmc Myocardial tagging by cardiovascular magnetic resonance: evolution of techniques--pulse sequences, analysis algorithms, and applications
    El Sayed H Ibrahim
    Department of Radiology, University of Florida, Jacksonville, USA
    J Cardiovasc Magn Reson 13:36. 2011
    ..Finally, the current article includes a plethora of ideas and techniques with over 300 references that motivate the reader to think about the future of CMR tagging...
  71. ncbi Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction
    Francisco Fernandez-Aviles
    Instituto de Ciencias del Corazón ICICOR, Hospital Clínico Universitario C O Ramón y Cajal 3, E 47005 Valladolid, Spain
    Circ Res 95:742-8. 2004
    ..Large-scale randomized trials are needed now to assess the clinical efficacy of this treatment...
  72. ncbi Evaluation of the clinical relevance of baseline left ventricular ejection fraction as a predictor of recovery or persistence of severe dysfunction in women in the United States with peripartum cardiomyopathy
    Sorel Goland
    Division of Cardiovascular Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Card Fail 17:426-30. 2011
    ..Baseline left ventricular ejection fraction (LVEF) has been shown to be associated with likelihood of recovery in patients with peripartum cardiomyopathy (PPCM). The clinical relevance of this association for individual patients is unclear...
  73. ncbi Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St, Suite 650, Philadelphia, PA 19107, USA
    Chest 134:172-8. 2008
    ..Central venous pressure (CVP) is used almost universally to guide fluid therapy in hospitalized patients. Both historical and recent data suggest that this approach may be flawed...
  74. ncbi Clinically significant change in stroke volume in pulmonary hypertension
    Serge A van Wolferen
    VU University Medical Center, Department of Pulmonary Disease, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Chest 139:1003-9. 2011
    b>Stroke volume is probably the best hemodynamic parameter because it reflects therapeutic changes and contains prognostic information in pulmonary hypertension (PH)...
  75. ncbi Ischaemic postconditioning revisited: lack of effects on infarct size following primary percutaneous coronary intervention
    Xavier Freixa
    Interventional Cardiology Section, Cardiology Department, Thorax Institute, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona 08036, Catalonia, Spain
    Eur Heart J 33:103-12. 2012
    ..Previous studies have shown that p-cond during primary percutaneous coronary intervention (PCI) confers protection against ischaemia-reperfusion injury and thus might reduce myocardial infarct size...
  76. ncbi Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy
    Johanna A Miettinen
    University of Oulu, Department of Internal Medicine P O Box 5000 Kajaanintie 50, FIN 90014 University of Oulu, Oulu, Finland
    Heart 96:362-7. 2010
    ....
  77. ncbi Speckle-tracking radial strain reveals left ventricular dyssynchrony in patients with permanent right ventricular pacing
    Laurens F Tops
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 50:1180-8. 2007
    ..Speckle-tracking strain analysis was used to assess the effects of permanent right ventricular (RV) pacing on the heterogeneity in timing of regional wall strain and left ventricular (LV) dyssynchrony...
  78. ncbi Assessment of subendocardial vs. subepicardial left ventricular rotation and twist using two-dimensional speckle tracking echocardiography: comparison with tagged cardiac magnetic resonance
    Céline Goffinet
    Division of Cardiology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Eur Heart J 30:608-17. 2009
    ....
  79. pmc Antidepressant use, depression, and survival in patients with heart failure
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, 2400 N Pratt St, Box 3356, Durham, NC 27705, USA
    Arch Intern Med 168:2232-7. 2008
    ..Because depression has also been shown to be associated with increased mortality in these patients, it remains unclear if this association is attributable to the use of antidepressants or to depression...
  80. ncbi The pathophysiology of the aqueduct stroke volume in normal pressure hydrocephalus: can co-morbidity with other forms of dementia be excluded?
    Grant A Bateman
    Department of Medical Imaging, John Hunter Hospital, Locked Bag 1, Newcastle Region Mail Centre, Newcastle, 2310, Australia
    Neuroradiology 47:741-8. 2005
    ..study seeks to (1) understand the physiological factors behind, and (2) define the ability of, the aqueduct stroke volume to exclude dementia co-morbidity...
  81. ncbi Assessment of global right ventricular function on 64-MDCT compared with MRI
    Cedric Plumhans
    Department of Diagnostic Radiology, RWTH Aachen University Hospital, D 52057 Aachen, Germany
    AJR Am J Roentgenol 190:1358-61. 2008
    ..The aim of this study was to compare ECG-gated 64-MDCT with MRI for the assessment of global right ventricular (RV) function from coronary CT angiography data...
  82. pmc Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction
    Mark A Tanner
    Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, UK
    J Cardiovasc Magn Reson 10:12. 2008
    ..Combined chelation therapy with deferiprone and deferoxamine is effective for moderate myocardial siderosis, but has not been prospectively examined in severe myocardial siderosis...
  83. ncbi Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction
    Nazha Hamdani
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Eur Heart J 30:1863-72. 2009
    ....
  84. pmc Three-dimensional echocardiography using single-heartbeat modality decreases variability in measuring left ventricular volumes and function in comparison to four-beat technique in atrial fibrillation
    Kambiz Shahgaldi
    Department of Cardiology, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Cardiovasc Ultrasound 8:45. 2010
    ....
  85. ncbi Cardiac resynchronization in chronic heart failure
    William T Abraham
    Division of Cardiovascular Medicine, University of Kentucky College of Medicine, Lexington 40536 0284, USA
    N Engl J Med 346:1845-53. 2002
    ..We conducted a double-blind trial to evaluate this therapeutic approach...
  86. pmc Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload
    John Paul Carpenter
    Cardiovascular MR Unit, Royal Brompton Hospital, London, London, UK
    J Cardiovasc Magn Reson 12:24. 2010
    ..We aimed to define reference ranges for right ventricular (RV) volumes, ejection fraction (EF) in thalassemia major patients (TM) without myocardial iron overload...
  87. ncbi A critical comparison of echocardiographic measurements used for optimizing cardiac resynchronization therapy: stroke distance is best
    Dewi E Thomas
    Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Eur J Heart Fail 11:779-88. 2009
    ..We also assessed the utility of 'stroke distance' [left ventricular outflow tract velocity-time integral (LVOT VTI)] in performing this function...
  88. pmc Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging
    Zaheer R Yousef
    Department of Cardiology, Good Hope Hospital, Sutton Coldfield, West Midlands, UK
    BMC Cardiovasc Disord 9:37. 2009
    ..It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction...
  89. ncbi Myocardial fibrosis identified by cardiac magnetic resonance late gadolinium enhancement is associated with adverse ventricular mechanics and ventricular tachycardia late after Fontan operation
    Rahul H Rathod
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 55:1721-8. 2010
    ..The purpose of this study was to evaluate the relationship between myocardial fibrosis identified by cardiac magnetic resonance (CMR) and ventricular performance and arrhythmias in patients late after the Fontan operation...
  90. ncbi Improved ejection fraction after exercise training in obesity is accompanied by reduced cardiac lipid content
    Vera B Schrauwen-Hinderling
    Department of Radiology, Maastricht University Medical Center, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 95:1932-8. 2010
    ..In skeletal muscle, physical activity paradoxically increases fat accumulation, despite improvement in insulin sensitivity. Whether cardiac muscle responds similarly remains unknown...
  91. ncbi Cell-based therapy for myocardial repair in patients with acute myocardial infarction: rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction (SWISS-AMI)
    Daniel Sürder
    Department of Cardiology, University Hospital Zurich, Zurich, Switzerland
    Am Heart J 160:58-64. 2010
    ..Furthermore, reliable clinical predictors are lacking for identifying patients who are thought to have most benefit from cellular therapy...
  92. ncbi Oxygen transport characterization of a human model of progressive hemorrhage
    Kevin R Ward
    Virginia Commonwealth University Reanimation Engineering Shock Center VCURES, 1201 East Marshall Street, P O Box 980401, Richmond, VA 23298, United States
    Resuscitation 81:987-93. 2010
    ..We examined changes in oxygen transport produced by central volume redistribution in humans using lower body negative pressure (LBNP) as a potential mimetic of hemorrhage...
  93. ncbi Recommendations of the European Association of Echocardiography: how to use echo-Doppler in clinical trials: different modalities for different purposes
    Maurizio Galderisi
    Echocardiography Laboratory, Cardioangiology with CCU, Department of Clinical and Experimental Medicine, Federico II University Hospital of Naples, Block 1, Via S Pansini 5, 80131 Naples, Italy
    Eur J Echocardiogr 12:339-53. 2011
    ..Quality assurance must be guaranteed by adequate training of peripheral site operators to obtain optimal echo-Doppler data and by using a core laboratory for accurate and reproducible data analysis...
  94. pmc Prediction of global left ventricular functional recovery in patients with heart failure undergoing surgical revascularisation, based on late gadolinium enhancement cardiovascular magnetic resonance
    Tammy J Pegg
    University of Oxford Centre for Clinical Magnetic Resonance Research, UK
    J Cardiovasc Magn Reson 12:56. 2010
    ..Finally, we examined which segmental transmural threshold of scarring best predicted global LV recovery...
  95. pmc Dyssynchrony by speckle-tracking echocardiography and response to cardiac resynchronization therapy: results of the Speckle Tracking and Resynchronization (STAR) study
    Hidekazu Tanaka
    University of Pittsburgh, Scaife Hall 564, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Eur Heart J 31:1690-700. 2010
    ..The Speckle Tracking and Resynchronization (STAR) study used a prospective multi-centre design to test the hypothesis that speckle-tracking echocardiography can predict response to cardiac resynchronization therapy (CRT)...
  96. ncbi Treatment of heart failure with normal ejection fraction: an inconvenient truth!
    Walter J Paulus
    Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:526-37. 2010
    ..Nonadherence to guidelines also led to underpowered HFNEF trials with a low incidence of outcome events such as death or HF hospitalizations. Future HFNEF trials should therefore adhere to diagnostic guidelines for HFNEF...
  97. ncbi Decreasing cardiac chamber sizes and associated heart dysfunction in COPD: role of hyperinflation
    Henrik Watz
    Pulmonary Research Institute, Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, D 22927 Grosshansdorf, Germany
    Chest 138:32-8. 2010
    ..We studied the relationship of lung function with heart size and heart dysfunction and associated consequences for 6-min walk distance (6MWD) in patients with COPD of different severitites...
  98. ncbi Prognostic utility of B-type natriuretic peptide assessment in stable low-risk outpatients with nonischemic cardiomyopathy after decompensated heart failure
    Mototsugu Nishii
    Department of Cardio angiology, Kitasato University School of Medicine, Sagamihara, Japan
    J Am Coll Cardiol 51:2329-35. 2008
    ..We investigated the clinical utility of B-type natriuretic peptide (BNP) assay in stable outpatients with nonischemic dilated cardiomyopathy (NICM) after decompensated heart failure (HF)...
  99. ncbi Cardiac improvement during mechanical circulatory support: a prospective multicenter study of the LVAD Working Group
    Simon Maybaum
    Albert Einstein College of Medicine, Center for Advanced Cardiac Therapy, 3400 Bainbridge Ave, 7th Floor, Bronx, NY 10467 2490, USA
    Circulation 115:2497-505. 2007
    ..The LVAD Working Group Recovery Study was a prospective multicenter trial to assess the incidence of myocardial recovery in patients bridged to cardiac transplantation...
  100. ncbi Quality of care of nursing home residents hospitalized with heart failure
    Ali Ahmed
    Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Alabama, Birmingham, AL, USA
    J Am Geriatr Soc 50:1831-6. 2002
    ..To determine whether the quality of heart failure (HF) care of hospitalized nursing home (NH) residents is different from that of patients admitted from other locations...
  101. ncbi Arterial stiffness and arterial wave reflections are associated with systolic and diastolic function in patients with normal ejection fraction
    Thomas Weber
    Cardiology Department, Klinikum Wels Grieskirchen, Wels, Austria
    Am J Hypertens 21:1194-202. 2008
    ..We investigated, whether impaired arterial function is associated with impaired systolic and diastolic function and symptomatic status...

Research Grants65

  1. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..NSP is expressed by neurons, monocytes, and multiple organs, and is reported to reduce stroke volume in rodent models and in recent work from our lab, reduced transplant vasculopathy (Fig 1, Research Proposal)...
  2. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..function of larger vessels, and in particular the aorta, modulates hemodynamics by accommodating a portion of stroke volume during systole, reducing systolic pressure and maintaining systemic perfusion during diastole...
  3. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..associations of airflow obstruction and emphysema on CT scan with reduced LV end-diastolic volume, LV stroke volume and cardiac output but not LV-EF on magnetic resonance imaging, particularly among smokers...
  4. Mechanisms of Meditation in Hypertension in Blacks
    Robert Schneider; Fiscal Year: 2010
    ..plasma catecholamine reactivity to lab stressors;hemodynamic responses, comprising heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance;arterial compliance, and cardiac autonomic nervous system ..
  5. Frequency-dependent modulation of cardiac myofilament function in health/disease
    PAULUS ML JANSSEN; Fiscal Year: 2013
    ..rate goes up significantly, and the specific force generated by the myocardium increases as well, boosting stroke volume. The latter phenomenon is known as the force-frequency relationship (FFR)...
  6. Titin-based adaptations of cardiac function
    Henk L Granzier; Fiscal Year: 2013
    ..e., the increase in contractility with length. Although the FSM is critical for adjusting stroke volume to match venous return, the mechanism(s) underlying the FSM have remained elusive...
  7. Exercise adaptations in mitochondrial myopathy: therapeutic implications
    Ronald G Haller; Fiscal Year: 2012
    ..and cardiovascular function will be assessed by monitoring peak work, oxygen utilization, cardiac output and stroke volume in cycle exercise, and by monitors of quality of life...
  8. COOPERATIVE THIN FILAMENT ACTIVATION IN STRIATED MUSCLE
    Michael Regnier; Fiscal Year: 2012
    ..may allow for greater cellular level of controlling force in cardiac muscle, which is required to match stroke volume with venous return on a beat-to-beat basis, i.e. the Frank-Starling Law of the Heart...
  9. Rescue of Beta-Adrenergic Cardiomyopathy by Inhibition of Adenylyl Cyclase
    Dorothy E Vatner; Fiscal Year: 2012
    ..by inhibition of AC5 permits enhanced exercise performance which is due to (1) improved cardiac output and stroke volume, (2) improved coronary reserve, and (3) enhanced nitric oxide (NO) signaling...
  10. LENGTH REGULATION OF CARDIAC CONTRACTION
    Donald Martyn; Fiscal Year: 2010
    ..provided by applicant): Normal heart function is dependent on the Frank-Starling mechanism of matching stroke volume to venous return to adjust cardiac output with changes in metabolic demand...
  11. BAROREFLEX AND POSTERIOR HYPOTHALAMIC NEUROPEPTIDE-Y
    John Martin; Fiscal Year: 1991
    ..measured in order to determine the effect of sympathetic and/or parasympathetic activity on cardiac output, stroke volume and total peripheral resistance...
  12. Portable pneumatic driver for counterpulsation therapy
    Paul A Spence; Fiscal Year: 2010
    ..The CPD is a 32-ml stroke volume polyurethane-lined blood chamber designed to fit comfortably in a subcutaneous pocket on the right anterior ..
  13. Improved arrhythmia imaging with MR compatible 12-lead ECG
    EHUD JERUHAM SCHMIDT; Fiscal Year: 2013
    ..The separated MHD signals (VMHD) will be used for a non- invasive estimation of systolic beat-to-beat cardiac stroke volume (SV...
  14. Counterpulsation Device with Integrated ECG Sensing
    Robert D Dowling; Fiscal Year: 2010
    ..The CPD is a 32-ml stroke volume polyurethane-lined blood chamber designed to fit comfortably in a subcutaneous pocket on the right anterior ..
  15. Development of a Pediatric Ventricular Assist Device
    WEISS WILLIAM J; Fiscal Year: 2009
    ..Two pediatric pump sizes will be developed;a 10 ml stroke volume pump for infants, and a 25 ml stroke volume pump for children. The adult pump has a 65 ml stroke volume...
  16. Influences of Lymph Flow on the Lymphatic Pump
    DAVID CARL ZAWIEJA; Fiscal Year: 2010
    ..rate of pressure change, diameter, rate of diameter change, contraction frequency, ejection fraction, stroke volume, flow, can be determined to analyze lymphatic contractile function...
  17. Neural bases of empathy and prosody
    Argye E Hillis; Fiscal Year: 2013
    ..The effects of age, brain volume, stroke volume, and metabolic factors, as well as location of dysfunctional tissue on the degree of impairment will be ..
  18. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2004
    ..On day two, subjects undergo testing that includes hemodynamics (BP, heart rate, stroke volume, cardiac output, calculated vascular resistance, arterial compliance) and indices of oxidative stress (plasma ..
  19. Pre-clinical Testing of a VAD for Uni- and Bi-ventricular Support in Infants
    William J Weiss; Fiscal Year: 2013
    ..The Penn State Infant VAD is a pulsatile pneumatically-actuated pump with a 12-14 ml stroke volume. The device has demonstrated low thrombogenicity in pilot animal studies, in part due to the custom Bjork-..
  20. Xanthine oxidase inhibitor for congestive heart failure
    Alex Nivorozhkin; Fiscal Year: 2002
    ..Cardiac contractility will be assessed using left ventricular pressure-volume analysis, dP/dT, stroke volume, and ejection fraction...
  21. A counterpulsation device to promote myocardial recovery
    Paul Spence; Fiscal Year: 2006
    ..The 30-ml CPD provides a better fit and more comfortable implantation in the shoulder area, but its stroke volume is reduced by 25%, and this change requires verification that it can provide sufficient hemodynamic support...
  22. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2005
    ..And, after pMCAo, they show decreases in brain stroke volume and in lipid peroxidation. Also, Tg mice neurons are resistant to H2O2 and glutamate toxicity...
  23. Pathophysiology of Heart Failure with a Normal Ejection Fraction in the Elderly
    Mathew S Maurer; Fiscal Year: 2010
    ..In the setting of a normal ejection fraction with end diastolic volume increased, stroke volume must increase, indicating a high output state. High output states involve peripheral (i.e...
  24. CARDIOVASCULAR EFFECTS OF COCAINE
    MARK KNUEPFER; Fiscal Year: 2001
    ..Using measurements of several cardiovascular variables (e.g. cardiac output, systemic vascular resistance, stroke volume, and heart rate), we have identified variability in response characteristics that is related to variability in ..
  25. ORTHOSTATIC HYPOTENSION IN OLDER PERSONS
    JEANNE WEI; Fiscal Year: 1992
    ..Due to myocardial dysfunction, the person is unable to raise the pressure by increasing stroke volume. The individual is also unable to maintain cardiac output by cardioacceleration, and hypotension ensues...
  26. Development of a Counterpulsation Therapy Device
    Paul Spence; Fiscal Year: 2009
    ..The CPD is 32-ml stroke volume, valveless pneumatically-driven blood sac with a single inflow/outflow cannula...
  27. COMPUTATIONAL METHODS IN CARDIAC FLUID DYNAMICS
    CHARLES PESKIN; Fiscal Year: 1990
    ..in which the cardiac simulator will be used to optimize valve performance with respect to pressure drop, net stroke volume, and thrombogenesis...
  28. CARDIAC RESPONSE TO ESTROGEN & HYPERTENSION
    MARK MORTON; Fiscal Year: 1991
    ..include: measurement of high fidelity left ventricular pressure, minor axis dimension, wall thickness, and stroke volume by electromagnetic flow sensor...
  29. Skin Cooling to Improve Orthostatic Tolerance
    CRAIG CRANDALL; Fiscal Year: 2005
    ..e. stroke volume, blood pressure, sympathetic nerve activity, etc.) without causing shivering or altering motor function...
  30. Development of an Infant VAD System for Long Term Uni- and Bi-ventricular Support
    William J Weiss; Fiscal Year: 2012
    ..The Infant VAD has a dynamic stroke volume of 14 ml, and is capable of supporting the circulation for periods up to one year...
  31. DIASTOLIC PROPERTIES OF DEVELOPING MYOCARDIUM
    Kent Thornburg; Fiscal Year: 1993
    ..to affect diastolic function in mature myocardium; determine the role of diastolic ventricular interaction in determining increased left ventricular stroke volume at birth; and correlate cellular events with in vivo functional changes.
  32. BEDSIDE SYSTEM FOR COMBINED RNA AND PACIN HEART FAILURE
    Jeffrey Lacy; Fiscal Year: 2001
    ..will yield LV and RV ejection fractions, right heart, pulmonary, and left atrial pressures, cardiac output, stroke volume, wall motion, pulmonary blood volume, and, most significantly, absolute RV and LV volume curves, so that ..
  33. PHYSIOLOGIC RESPONSES TO CHRONIC COLD EXPOSURE
    M Phillips; Fiscal Year: 1999
    ..For this, cardiac output and contractility, stroke volume, right atrial pressure, total peripheral resistance, resistance of the hind quarters to blood flow, vascular ..
  34. HYPERTENSION, CIRCUMVENTRICULAR ORGANS, NUTRIENTS
    DIANE HARTLE; Fiscal Year: 1990
    ..Protocol are described for determination of blood pressure parameters, cardiac output, heart rate, stroke volume, total peripheral resistance and regional blood flow changes in SHR vs WKY rats...
  35. RIGHT & LEFT VENTRICULAR FUNCTION DURING FETAL HYPOXEMIA
    Mark Reller; Fiscal Year: 1990
    ..Using this model, fetal hypoxemia is frequently associated with reduced cardiac output due to reduced stroke volume and arterial hypertension...
  36. LEFT VENTRICLE OF THE DEVELOPING HEART
    Page Anderson; Fiscal Year: 1990
    ..2) With birth LV end-diastolic volume (LVEDV) increases, enhancing LV stroke volume (SV)...
  37. MINIATURE ELECTROHYDRAULIC TOTAL ARTIFICIAL HEART
    FRED ZARINETCHI; Fiscal Year: 1999
    ..The device operates as a simpler low stroke volume, high beat rate pump, which can deliver up to 7 L/min against a l00 mmHg afterload, and has the potential to ..
  38. HEMODYNAMIC PROBLEMS IN ARRHYTHMIA SURGERY
    HENRY SPOTNITZ; Fiscal Year: 1990
    ..will allow surgeons to optimize LV repair by balancing geometric-dependent variables such as wall tension and stroke volume. The effects of chronically-implanted AICD patch electrodes on diastolic and systolic LV properties will be ..
  39. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2007
    ..In experimental stroke models, inhibition of the inflammatory cascade after stroke reduces BBB disruption and stroke volume. However, analysis of pathologic mechanisms related to BBB disruption in vivo is complicated by inherent ..
  40. CARDIAC OUTPUT FROM THE PNEUMOCARDIOGRAM
    JOE BOURLAND; Fiscal Year: 1980
    ..program is to develop a microprocessor-based instrumentation system which will permit calculation of cardiac stroke volume, and consequently, cardiac output from signals which can be measured noninvasively...
  41. Acute stroke protection by erythropoietin and IGF-I
    Murat Digicaylioglu; Fiscal Year: 2007
    ..in histological sections, and the possible beneficiary effect of EPO?I will be documented by measuring stroke volume. In addition, we will study the signaling pathway triggered by EPO and IGF-I interaction with their respective ..
  42. QUANTIFICATION OF INTRATHORACIC FLUID BY IMPEDANCE
    Lee Baker; Fiscal Year: 1980
    ..the extent to which interactions of intrathoracic fluids, tissue edema, and PEEP modify the thoracic impedance waveform and thereby the measurement of respired volume, stroke volume, and cardiac output using the impedance technique.
  43. TUBULAR PEDIATRIC VENTRICULAR ASSIST DEVICE
    Robert Kung; Fiscal Year: 1993
    ..The valves and pumps are actuated pneumatically. The designed stroke volume is under 10cc suitable for neonates and infants weighing up to 10kg...
  44. 100ML STROKE VOLUME ELIPTICAL TAH IN 50KG RECIPIENTS
    Don Olsen; Fiscal Year: 1992
    This proposal is to study the efficaciousness of a large stroke volume (100 ml) small elliptical heart orothotopically placed in 50 kg animals...
  45. DYNAMIC CARDIOMYOPLASTY
    WILLIAM SANTAMORE; Fiscal Year: 2001
    ..With this muscle, LDM stimulation should increase LV pressure by 15 to 20 mmHg and stroke volume by 20 to 30 percent. We will test these interventions in 2 sections...
  46. WATER COMPARTMENTALIZATION IN CHRONIC FETAL ANEMIA
    Lowell Davis; Fiscal Year: 2007
    ..sheep, adaptation to chronic anemia includes a 30% increase in heart to body weight ratio, a 50% increase in stroke volume and cardiac output, a six-fold increase in coronary blood flow, and a doubling of coronary conductance with ..
  47. Automated Screening System for Modifiers of Cardiac Output in Zebrafish
    ANTHONY FERRANTE; Fiscal Year: 2009
    ..heart rate but do not address other critical parameters of cardiovascular function such as blood velocity, stroke volume and ejection fraction...
  48. RENEWAL OF THE NEW JERSEY CFS CRC
    Benjamin Natelson; Fiscal Year: 2002
    ..based on the variables that track these putative organic causes -- namely cognitive dysfunction and cardiac stroke volume. By using a median split approach, we will have data from 4 groups of patients and can make a priori ..
  49. RISK MARKERS FOR DEMENTIA AFTER STROKE
    David Nyenhuis; Fiscal Year: 2004
    ..is to identify risk markers such as hippocampal and entorhinal cortex volume, white matter dysfunction, stroke volume, and generalized brain volume by quantitative MRI technology that may contribute to dementia and cognitive ..
  50. NICOTINE WITHDRAWAL & RESPONSES TO PSYCHOLOGICAL STRESS
    MUSTAFA AL ABSI; Fiscal Year: 2000
    ..During lab sessions, we will also monitor heart rate, systolic and diastolic blood pressure, and measure stroke volume using impedance cardiography...
  51. Spinal Cord Injury and Heat Acclimation
    JONATHAN WINGO; Fiscal Year: 2009
    ..during a given thermal challenge, 3) and result in lower cardiovascular strain (lower heart rate and higher stroke volume) during exercise...
  52. Effects of Vestibular Loss on Orthostatic Mechanisms
    Scott Wood; Fiscal Year: 2004
    ..Modulation of arterial blood pressure, heart rate, stroke volume, peripheral vascular resistance, end-tidal C02, respiratory rate and volume, cerebral blood flow velocity and ..
  53. Anxiety and Delayed Type Hypersensitivity Responses
    Mark Larson; Fiscal Year: 2002
    ..The acute stressor would be a simulated public speaking task. Heart rate, stroke volume, pre-ejection period and left ventricular ejection time would be measured continuously and non-invasively ..
  54. ADAPTATIONS TO ENDURANCE EXERCISE IN HEALTHY ELDERLY
    Ellen Evans; Fiscal Year: 2000
    ..peripheral mechanisms responsible for any increase in VO2max by measuring maximal cardiac output, calculating stroke volume and oxygen extraction, and assessing skeletal muscle histochemical and enzymatic adaptations; b) further ..
  55. EVALUATING ARTERIAL DISEASE BY VELOCITY-WAVE ANALYSIS
    Robert Rutherford; Fiscal Year: 1980
    ..The clinical value of femoral artery velocity waveform analysis in predicting the presence and severity of proximal or distal occlusive lesions will be explored. ..
  56. BEAT-TO-BEAT VARIABILITY IN HEMODYNAMIC PARAMETERS
    Richard Cohen; Fiscal Year: 1993
    Hemodynamic parameters such as heart rate, arterial blood pressure stroke volume fluctuate on a beat-to-beat basis as a result of the dynamic interplay between ongoing perturbations to the cardiovascular system and the response of the ..
  57. PHYSIOLOGY OF THE MESENTERIC LYMPHATIC PUMP
    JOSEPH BENOIT; Fiscal Year: 1993
    ..e., basic cardiac function parameters (e.g., contractile frequency, stroke volume, ejection fraction) are used to analyze the flow generating capabilities of the lymph "Hearts"...
  58. HYPERTENSION IN THE ELDERLY--EFFECTS OF EXERCISE
    DOUGLAS SEALS; Fiscal Year: 1992
    ..Cardiac output, systemic vascular resistance, heart rate, stroke volume, cardiac autonomic efferent activity, cardiac dimensions and contractility, efferent sympathetic nerve ..
  59. The role of Hypoxia Inducible Factor-1 alpha in stroke
    David Rempe; Fiscal Year: 2007
    ..The effect of loss of HIF-1 alpha function on stroke volume will also be explored in a focal model of stroke...
  60. CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISE TRAINING
    Dalane Kitzman; Fiscal Year: 2007
    ..abstract_text> ..
  61. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..
  62. EXERCISE INTOLERANCE IN ELDERLY DIASTOLIC HEART FAILURE
    Dalane Kitzman; Fiscal Year: 2004
    ..abstract_text> ..
  63. PRENATAL PCB EXPOSURE AND ACUTE STRESS REACTIVITY
    Brooks Gump; Fiscal Year: 2003
    ..g., cognitive functioning). ..
  64. HERITAGE FAMILY STUDY, PHASE 4
    Tuomo Rankinen; Fiscal Year: 2010
    ..abstract_text> ..