cardiac output

Summary

Summary: The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).

Top Publications

  1. ncbi Cardiac output monitoring
    Eric E C de Waal
    Division of Perioperative and Emergency Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Curr Opin Anaesthesiol 22:71-7. 2009
  2. ncbi Run sprint interval training improves aerobic performance but not maximal cardiac output
    Rebecca E K Macpherson
    Exercise Nutrition Research Laboratory, Faculty of Health Sciences, School of Kinesiology, The University of Western Ontario, London, Canada
    Med Sci Sports Exerc 43:115-22. 2011
  3. ncbi Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 9:872-8. 2007
  4. ncbi The respiratory variation in inferior vena cava diameter as a guide to fluid therapy
    Marc Feissel
    Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
    Intensive Care Med 30:1834-7. 2004
  5. ncbi Equivalence of the bioimpedance and thermodilution methods in measuring cardiac output in hospitalized patients with advanced, decompensated chronic heart failure
    Nancy M Albert
    Division of Nursing, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Crit Care 13:469-79. 2004
  6. ncbi Accuracy and repeatability of pediatric cardiac output measurement using Doppler: 20-year review of the literature
    Michelle S Chew
    Department of Anesthesia and Intensive Care, Lund University Hospital, 22185, Lund, Sweden
    Intensive Care Med 29:1889-94. 2003
  7. ncbi Respiratory changes in aortic blood velocity as an indicator of fluid responsiveness in ventilated patients with septic shock
    M Feissel
    , Centre Hospitalier, Belfort, France
    Chest 119:867-73. 2001
  8. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
  9. pmc Balance between cardiac output and sympathetic nerve activity in resting humans: role in arterial pressure regulation
    N Charkoudian
    Department of Physiology and Biomedical Engineering, JO 4184W, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 568:315-21. 2005
  10. ncbi A critical review of the ability of continuous cardiac output monitors to measure trends in cardiac output
    Lester A Critchley
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Anesth Analg 111:1180-92. 2010

Detail Information

Publications404 found, 100 shown here

  1. ncbi Cardiac output monitoring
    Eric E C de Waal
    Division of Perioperative and Emergency Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Curr Opin Anaesthesiol 22:71-7. 2009
    ..The most ideal cardiac output (CO) monitor should be reliable, continuous, noninvasive, operator-independent and cost-effective and should ..
  2. ncbi Run sprint interval training improves aerobic performance but not maximal cardiac output
    Rebecca E K Macpherson
    Exercise Nutrition Research Laboratory, Faculty of Health Sciences, School of Kinesiology, The University of Western Ontario, London, Canada
    Med Sci Sports Exerc 43:115-22. 2011
    ..However, most SIT data use cycling, and little is known about its effects on body composition or maximal cardiac output (Qmax).
  3. ncbi Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 9:872-8. 2007
    Renal failure in heart failure is related to decreased cardiac output. However, little is known about its association with venous congestion.
  4. ncbi The respiratory variation in inferior vena cava diameter as a guide to fluid therapy
    Marc Feissel
    Réanimation Médicale et Maladies Infectieuses, Centre Hospitalier de Belfort, Belfort, France
    Intensive Care Med 30:1834-7. 2004
    ..To investigate whether the respiratory variation in inferior vena cava diameter (DeltaD(IVC)) could be related to fluid responsiveness in mechanically ventilated patients...
  5. ncbi Equivalence of the bioimpedance and thermodilution methods in measuring cardiac output in hospitalized patients with advanced, decompensated chronic heart failure
    Nancy M Albert
    Division of Nursing, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Crit Care 13:469-79. 2004
    An accurate and reliable noninvasive method for determining cardiac output/cardiac index would be valuable for patients with acutely decompensated advanced systolic heart failure.
  6. ncbi Accuracy and repeatability of pediatric cardiac output measurement using Doppler: 20-year review of the literature
    Michelle S Chew
    Department of Anesthesia and Intensive Care, Lund University Hospital, 22185, Lund, Sweden
    Intensive Care Med 29:1889-94. 2003
    Review of the accuracy and repeatability of Doppler cardiac output (CO) measurements in children.
  7. ncbi Respiratory changes in aortic blood velocity as an indicator of fluid responsiveness in ventilated patients with septic shock
    M Feissel
    , Centre Hospitalier, Belfort, France
    Chest 119:867-73. 2001
    ....
  8. ncbi Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension
    B Tavernier
    Department of Anesthesia 2, University Hospital, Lille, France
    Anesthesiology 89:1313-21. 1998
    ..maximal and minimal systolic blood pressure values during one mechanical breath), and its delta down (dDown) component (= apneic - minimum systolic blood pressure) with the response of cardiac output to volume expansion during sepsis.
  9. pmc Balance between cardiac output and sympathetic nerve activity in resting humans: role in arterial pressure regulation
    N Charkoudian
    Department of Physiology and Biomedical Engineering, JO 4184W, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 568:315-21. 2005
    ..We studied the relationship between cardiac output (CO) and baroreflex control of sympathetic activity by measuring MSNA (peroneal microneurography), arterial ..
  10. ncbi A critical review of the ability of continuous cardiac output monitors to measure trends in cardiac output
    Lester A Critchley
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Anesth Analg 111:1180-92. 2010
    Numerous cardiac output (CO) monitors have been produced that provide continuous rather than intermittent readings. Bland and Altman has become the standard method for validating their performance against older standards...
  11. ncbi Noninvasive cardiac output monitoring (NICOM): a clinical validation
    Pierre Squara
    CERIC, Clinique Ambroise Pare, 27, boulevard Victor Hugo, 92200, Neuilly sur Seine, France
    Intensive Care Med 33:1191-4. 2007
    To evaluate the clinical utility of a new device for continuous noninvasive cardiac output monitoring (NICOM) based on chest bio-reactance compared with cardiac output measured semi-continuously by thermodilution using a pulmonary artery ..
  12. ncbi Cardiac output monitoring using indicator-dilution techniques: basics, limits, and perspectives
    Daniel A Reuter
    Department of Anesthesiology, Hamburg Eppendorf University Hospital, Martinistr 52, 20246 Hamburg, Germany
    Anesth Analg 110:799-811. 2010
    The ability to monitor cardiac output is one of the important cornerstones of hemodynamic assessment for managing critically ill patients at increased risk for developing cardiac complications, and in particular in patients with ..
  13. pmc Flow measurement by cardiovascular magnetic resonance: a multi-centre multi-vendor study of background phase offset errors that can compromise the accuracy of derived regurgitant or shunt flow measurements
    Peter D Gatehouse
    CMR Unit, Royal Brompton Hospital, London, UK
    J Cardiovasc Magn Reson 12:5. 2010
    ..We studied the severity of uncorrected velocity offset errors across sites and CMR systems...
  14. pmc Reduced cardiac output in imported Plasmodium falciparum malaria
    Johanna Herr
    University Medical Center Hamburg Eppendorf, Section Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Malar J 10:160. 2011
    ..In the present study, cardiac function and cardiac proteins have been assessed and correlated with parasitological and immunologic parameters in patients with imported Plasmodium falciparum malaria...
  15. ncbi Comparison of noninvasive cardiac output measurements using the Nexfin monitoring device and the esophageal Doppler
    Guo Chen
    Department of Anesthesiology and Perioperative Care, University of California, Irvine, CA 92868, USA
    J Clin Anesth 24:275-83. 2012
    To evaluate the validity of cardiac output (CO) measurements obtained using the Nexfin device in comparison to those obtained with the esophageal Doppler in steady-state conditions and after phenylephrine administration.
  16. ncbi The Fontan circulation: who controls cardiac output?
    Marc Gewillig
    Paediatric and Congenital Cardiology, University Hospitals Leuven, Belgium
    Interact Cardiovasc Thorac Surg 10:428-33. 2010
    In a Fontan circuit the mechanisms involved in control of cardiac output at rest and during exercise differ significantly from normal. The classical model presumes an unlimited preload which is not available in the Fontan circuit...
  17. pmc Cardiac output and cardiac index measured with cardiovascular magnetic resonance in healthy subjects, elite athletes and patients with congestive heart failure
    Marcus Carlsson
    Department of Clinical Physiology and Nuclear Medicine, BFC, Skane University Hospital, Lund University, Lund, SE 22185, Sweden
    J Cardiovasc Magn Reson 14:51. 2012
    Cardiovascular Magnetic Resonance (CMR) enables non-invasive quantification of cardiac output (CO) and thereby cardiac index (CI, CO indexed to body surface area)...
  18. ncbi Separating the direct effect of hypoxia from the indirect effect of changes in cardiac output on the maximum pressure difference across the tricuspid valve in healthy humans
    George M Balanos
    School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Pflugers Arch 450:372-80. 2005
    In healthy humans, changes in cardiac output are commonly accommodated with minimal change in pulmonary artery pressure. Conversely, exposure to hypoxia is associated with substantial increases in pulmonary artery pressure...
  19. ncbi A comparison of the Nexfin® and transcardiopulmonary thermodilution to estimate cardiac output during coronary artery surgery
    O Broch
    Department of Anaesthesiology and Intensive Care Medicine, Christian Albrechts University, Kiel, Germany
    Anaesthesia 67:377-83. 2012
    ..We compared the cardiac output derived from the Nexfin and PiCCO, using transcardiopulmonary thermodilution, during cardiac surgery...
  20. ncbi Comparison of uncalibrated arterial pressure waveform analysis with continuous thermodilution cardiac output measurements in patients undergoing elective off-pump coronary artery bypass surgery
    Yong Bo Jeong
    Department of Anesthesiology and Pain Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea
    J Cardiothorac Vasc Anesth 24:767-71. 2010
    Monitoring of cardiac output is required during anesthesia for off-pump coronary artery bypass (OPCAB) surgery...
  21. ncbi Hemodynamic and perfusion end points for volemic resuscitation in sepsis
    Fernando José da Silva Ramos
    Intensive Care and Anesthesiology Research Laboratory, Research and Education Institute, Hospital Sirio Libanes, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Shock 34:34-9. 2010
    ....
  22. ncbi Reliability of a new ultrasonic cardiac output monitor in recipients of living donor liver transplantation
    Bai Chuan Su
    Department of Anesthesia, Chang Gung Memorial Hospital Linkou, Kwei Shan, Taoyuan, Taiwan, Republic of China
    Liver Transpl 14:1029-37. 2008
    The ultrasonic cardiac output monitor (USCOM) is a new Doppler device for noninvasive hemodynamic monitoring...
  23. ncbi Performance of cardiac output measurement derived from arterial pressure waveform analysis in patients requiring high-dose vasopressor therapy
    S Metzelder
    Department of Anaesthesiology, University Hospital of the RWTH Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Br J Anaesth 106:776-84. 2011
    Arterial pressure waveform analysis of cardiac output (APCO) without external calibration (FloTrac/Vigileo™) is critically dependent upon computation of vascular tone that has necessitated several refinements of the underlying software ..
  24. ncbi Central venous pressure measurements improve the accuracy of leg raising-induced change in pulse pressure to predict fluid responsiveness
    Karim Lakhal
    Service de Réanimation Médicale et Maladies Infectieuses, Hopital Bichat Claude Bernard, Assistance Publique des Hopitaux de Paris, Paris, France
    Intensive Care Med 36:940-8. 2010
    ..We assessed the influence of PLR-induced changes in preload on the performance of PLR-induced change in pulse pressure (Delta(PLR)PP) and cardiac output (Delta(PLR)CO) for fluid responsiveness prediction.
  25. ncbi Circulatory responses to a meal in patients with a newly transplanted heart
    B A Waaler
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Post Box 1103, Blindern, 0317 Oslo, Norway
    Acta Physiol Scand 174:101-8. 2002
    ..quite marked increase in blood flow to the gastrointestinal organs and a similar and simultaneous increase in cardiac output (CO)...
  26. ncbi Fluid resuscitation preserves cardiac output but cannot prevent organ damage in a porcine model during 24 h of intraabdominal hypertension
    Alexander Schachtrupp
    Department of Surgery, Technical University of Aachen, Aachen, Germany
    Shock 24:153-8. 2005
    According to a previous study, a pathologically increased intraabdominal pressure (IAP) reduces cardiac output (CO) and results in medium- to high-grade organ damage in a porcine model of the abdominal compartment syndrome (ACS)...
  27. ncbi Prediction of fluid responsiveness in acute respiratory distress syndrome patients ventilated with low tidal volume and high positive end-expiratory pressure
    Chung Chi Huang
    Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Gweishan, Taoyuan, Taiwan
    Crit Care Med 36:2810-6. 2008
    ....
  28. ncbi Continuous cardiac output and near-infrared spectroscopy monitoring to assist in management of symptomatic cerebral vasospasm after subarachnoid hemorrhage
    Tatsushi Mutoh
    Department of Surgical Neurology, Research Institute for Brain and Blood Vessels Akita, 6 10 Senshu Kubota machi, Akita, 010 0874, Japan
    Neurocrit Care 13:331-8. 2010
    Hemodynamic augmentation by increasing cardiac output with dobutamine (DOB) is believed to be a useful method of elevating decreased cerebral blood flow in the territory affected by vasospasm following aneurysmal subarachnoid hemorrhage (..
  29. pmc Cardiac output as a potential risk factor for abnormal brain aging
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    J Alzheimers Dis 20:813-21. 2010
    ..data suggesting that subtle cardiac dysfunction or low normal levels of cardiac function, as quantified by cardiac output, are related to cognitive and neuroimaging markers of abnormal brain aging in the absence of heart failure or ..
  30. ncbi Assessment of intrathoracic blood volume as an indicator of cardiac preload: single transpulmonary thermodilution technique versus assessment of pressure preload parameters derived from a pulmonary artery catheter
    C Wiesenack
    Department of Anaesthesia, University Hospital, Regensburg, Germany
    J Cardiothorac Vasc Anesth 15:584-8. 2001
    OBJECTIVE: To analyze the clinical value of a new device (PiCCO) for cardiac output measurement and volume preload parameter assessment, based on transpulmonary thermodilution technique, as an alternative to the pulmonary artery ..
  31. ncbi Evaluation of a noninvasive continuous cardiac output monitoring system based on thoracic bioreactance
    Hanan Keren
    Cheetah Medical Limited, Ra anana, Israel
    Am J Physiol Heart Circ Physiol 293:H583-9. 2007
    Noninvasive cardiac output (CO) measurement can be useful in many clinical settings where invasive monitoring is not desired...
  32. ncbi Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices
    Pierre Squara
    Réanimation CERIC, Clinique Ambroise Pare, 27, boulevard Victor Hugo, 92200, Neuilly, France
    Intensive Care Med 35:1801-8. 2009
    Until now, tools for continuous cardiac output (CO) monitoring have been validated as if they were tools for snapshot measurements...
  33. ncbi The validity of trans-esophageal Doppler ultrasonography as a measure of cardiac output in critically ill adults
    Paul M Dark
    Department of Intensive Care Medicine, Injury, Repair and Rehabilitation Research Group, Hope Hospital, University of Manchester, Stott Lane, M6 8HD, Greater Manchester, UK
    Intensive Care Med 30:2060-6. 2004
    To determine the validity of the esophageal Doppler monitor (EDM) and echo-esophageal Doppler (Echo-ED) in measuring cardiac output in the critically ill.
  34. ncbi Flow measurement by magnetic resonance: a unique asset worth optimising
    Philip J Kilner
    CMR Unit, Royal Brompton Hospital, Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, Sydney Street, London, UK
    J Cardiovasc Magn Reson 9:723-8. 2007
    ..through planes transecting the great arteries should provide the most accurate measurements available of cardiac output, shunt flow, aortic or pulmonary regurgitation and, indirectly, of mitral regurgitation...
  35. pmc Clinical review: Positive end-expiratory pressure and cardiac output
    Thomas Luecke
    Department of Anesthesiology and Critical Care Medicine, University Hospital of Mannheim, Germany
    Crit Care 9:607-21. 2005
    ..As heart rate usually does not change with PEEP, the entire fall in cardiac output is a consequence of a reduction in left ventricular stroke volume (SV)...
  36. ncbi Non-invasive beat-to-beat cardiac output monitoring by an improved method of transthoracic bioimpedance measurement
    J Fortin
    Institute of Medical Engineering, Graz University of Technology, Krenngasse 37, A 8010 Graz, Austria
    Comput Biol Med 36:1185-203. 2006
    ..Examples of stroke volume and cardiac output curves underline the capabilities of the monitoring system "Task Force Monitor"...
  37. ncbi A meta-analysis of studies using bias and precision statistics to compare cardiac output measurement techniques
    L A Critchley
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Monit Comput 15:85-91. 1999
    Bias and precision statistics have succeeded regression analysis when measurement techniques are compared. However, when applied to cardiac output measurements, inconsistencies occur in reporting the results of this form of analysis.
  38. ncbi Cardiac output estimation with a new Doppler device after off-pump coronary artery bypass surgery
    Rajesh Chand
    Department of Anesthesiology and Critical Care, Escorts Heart Institute and Research Centre, New Delhi, India
    J Cardiothorac Vasc Anesth 20:315-9. 2006
    To compare cardiac output (CO), stroke volume (SV), and cardiac index (CI) as estimated with a new, noninvasive Doppler device (Ultrasonic Cardiac Output Monitor [USCOM]; USCOM Ltd, Sydney, Australia) with those measured with the bolus ..
  39. ncbi Effects of changes in vascular tone on the agreement between pulse contour and transpulmonary thermodilution cardiac output measurements within an up to 6-hour calibration-free period
    Olfa Hamzaoui
    Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, EA 4046, Université Paris 11, Le Kremlin Bicetre, France
    Crit Care Med 36:434-40. 2008
    ..To examine whether the agreement between pulse contour and transpulmonary thermodilution cardiac index (CI) measurements is altered by changes in vascular tone within an up to 6-hr calibration-free period...
  40. ncbi Echocardiographic measurement of fluid responsiveness
    Cyril Charron
    Medical Intensive Care Unit, University Hospital Ambroise Pare, Assistance Publique Hopitaux de Paris, Boulogne, France
    Curr Opin Crit Care 12:249-54. 2006
    ..In the last few years, several French teams have used echocardiography to develop new parameters of fluid responsiveness, taking advantage of its ability to monitor cardiac function beat by beat during the respiratory cycle...
  41. ncbi Minimal haemodynamic system model including ventricular interaction and valve dynamics
    Bram W Smith
    Department of Mechanical Engineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Med Eng Phys 26:131-9. 2004
    ..Examples of results include a 9% drop in cardiac output when increasing the thoracic pressure from -4 to 0 mmHg, and an increase in blood pressure from 120/80 to 165/..
  42. ncbi Determinants of maximal oxygen uptake in moderate acute hypoxia in endurance athletes
    Pascal Mollard
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, 74 rue Marcel Cachin, EA2363, ARPE, 93017 Bobigny Cedex, France
    Eur J Appl Physiol 100:663-73. 2007
    ..Heart rate (HR), stroke volume (SV), cardiac output (.Q), arterialized oxygen saturation (Sa'O2), oxygen uptake (.VO2max), ventilation (...
  43. ncbi Cardiac output and central distribution of blood flow in the human fetus
    G Mielke
    Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen, Germany
    Circulation 103:1662-8. 2001
    The objectives of this study were to establish reference ranges for left and right cardiac output and to investigate blood flow distribution through the foramen ovale, ductus arteriosus, and pulmonary bed in human fetuses.
  44. ncbi Fetal cardiac output, distribution to the placenta and impact of placental compromise
    T Kiserud
    Department of Clinical Medicine, Section of Obstetrics and Gynaecology, University of Bergen, Bergen, Norway
    Ultrasound Obstet Gynecol 28:126-36. 2006
    ..Our aim was to determine the normal distribution of fetal cardiac output to the placenta during the second half of pregnancy, and to assess the changes imposed by growth restriction ..
  45. pmc Beta-adrenergic or parasympathetic inhibition, heart rate and cardiac output during normoxic and acute hypoxic exercise in humans
    Susan R Hopkins
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Physiol 550:605-16. 2003
    Acute hypoxia increases heart rate (HR) and cardiac output (Qt) at a given oxygen consumption (VO2) during submaximal exercise...
  46. pmc Monitoring cardiac function in intensive care
    S M Tibby
    Department of Paediatric Intensive Care, Guy s Hospital, London SE1 9RT, UK
    Arch Dis Child 88:46-52. 2003
    ..afterload is difficult; thus in clinical practice the bedside assessment of cardiac function is represented by cardiac output. A variety of techniques are now available for cardiac output measurement in the paediatric patient...
  47. ncbi Noninvasive, automated and continuous cardiac output monitoring by pulmonary capnodynamics: breath-by-breath comparison with ultrasonic flow probe
    Philip J Peyton
    Department of Anesthesia, Austin Hospital, Heidelberg, Victoria, Australia
    Anesthesiology 105:72-80. 2006
    b>Cardiac output monitoring is most important where cardiovascular stability is potentially threatened, such as during major surgery and in critically ill patients...
  48. ncbi Reduced cardiac output is associated with decreased mitochondrial efficiency in the non-ischemic ventricular wall of the acute myocardial-infarcted dog
    Zakaria A Almsherqi
    Department of Physiology, National University of Singapore, Block MD9, 2 Medical Drive, Singapore 117597, Singapore
    Cell Res 16:297-305. 2006
    ..Hemodynamic measurements revealed a > 50% reduction in cardiac output at 24 h post infarction when compared to baseline...
  49. ncbi Volume-limited versus pressure-limited hemodynamic management in septic and nonseptic shock
    Ronald J Trof
    Department of Intensive Care, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Crit Care Med 40:1177-85. 2012
    ..To evaluate the effect of hemodynamic management guided by upper limits of cardiac filling volumes or pressures on durations of mechanical ventilation and lengths of stay in critically ill patients with shock...
  50. ncbi Third-generation FloTrac/Vigileo does not reliably track changes in cardiac output induced by norepinephrine in critically ill patients
    X Monnet
    Hôpitaux Universitaires Paris Sud, Hopital de Bicetre, Service de Reanimation Medicale, 78, rue du General Leclerc, Le Kremlin Bicêtre F 94270, France
    Br J Anaesth 108:615-22. 2012
    ..The ability of the third-generation FloTrac/Vigileo software to track changes in cardiac index (CI) induced by volume expansion and norepinephrine in critically ill patients is unknown...
  51. ncbi Discrepancy between cardiac and physical functional reserves in stroke
    Djordje G Jakovljevic
    Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Stroke 43:1422-5. 2012
    ..This study defines (1) whether exercise capacity is limited by the cardiovascular system (oxygen supply) or skeletal muscles (oxygen utilization); and (2) cardiac function and pumping capability in people with stroke...
  52. ncbi Cardiopulmonary effects of low-dose arginine vasopressin in ovine acute lung injury
    Martin Westphal
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 39:357-63. 2011
    ..To elucidate the effects of low-dose arginine vasopressin on cardiopulmonary functions and nitrosative stress using an established model of acute lung injury...
  53. ncbi Hemodynamics among neonates with hypoxic-ischemic encephalopathy during whole-body hypothermia and passive rewarming
    Corinna Mirjam Gebauer
    Department of Neonatology, Children s Hospital, University of Leipzig, Leipzig, Germany
    Pediatrics 117:843-50. 2006
    ..To assess changes in cardiac performance, with Doppler echocardiography, among newborns with hypoxic-ischemic encephalopathy during mild therapeutic hypothermia and during rewarming...
  54. ncbi Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output
    Angela F Dulhunty
    Department of Translational Biosciences, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Clin Exp Pharmacol Physiol 39:477-84. 2012
    ..Herein, we discuss known interactions between the RyR, triadin, junctin and CSQ with emphasis on the cardiac isoforms of the proteins. Where there is little known about the cardiac isoforms, we discuss evidence from skeletal isoforms...
  55. ncbi Arterial pressure allows monitoring the changes in cardiac output induced by volume expansion but not by norepinephrine
    Xavier Monnet
    Service de Reanimation Medicale, Hopital de Bicetre, AP HP, Le Kremlin Bicetre, France
    Crit Care Med 39:1394-9. 2011
    To evaluate to which extent the systemic arterial pulse pressure could be used as a surrogate of cardiac output for assessing the effects of a fluid challenge and of norepinephrine.
  56. ncbi A new impedance cardiograph device for the non-invasive evaluation of cardiac output at rest and during exercise: comparison with the "direct" Fick method
    A Charloux
    Service des Explorations Fonctionnelles Respiratoires, Cardio Circulatoires et de l Exercise, Hopitaux Universitaires de Strasbourg, Hopital Civil, France
    Eur J Appl Physiol 82:313-20. 2000
    ..We compared cardiac output determined simultaneously by two methods, the Physio Flow (QcPF) and the direct Fick (QcFick) methods...
  57. ncbi Reliability of peak VO(2) and maximal cardiac output assessed using thoracic bioimpedance in children
    Joanne Welsman
    Children s Health and Exercise Research Centre, University of Exeter, Heavitree Road, Exeter, EX1 2LU, UK
    Eur J Appl Physiol 94:228-34. 2005
    ..the reliability of a thoracic electrical bioimpedance based device (PhysioFlow) for the determination of cardiac output and stroke volume during exercise at peak oxygen uptake (peak VO(2) in children...
  58. ncbi Effects of ventilation on cardiac output determined by inert gas rebreathing
    Morten Damgaard
    Medical Department B, Department of Aviation Medicine, Copenhagen University Hospital, Denmark
    Clin Physiol Funct Imaging 25:142-7. 2005
    ..Therefore, in 10 healthy males we investigated the effects of changes in ventilation pattern on cardiac output (CO) estimated by an N(2)O-rebreathing technique. Reducing the rebreathing volume (V(reb)) from 1.5 to 1...
  59. ncbi The relationship between the photoplethysmographic waveform and systemic vascular resistance
    Aymen A Awad
    Department of Anesthesiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208051, New Haven, CT 06520 8051, USA
    J Clin Monit Comput 21:365-72. 2007
    ..The objective of this study was to determine the relationship between systemic vascular resistance (SVR), finger & ear photoplethysmographic measurements in 14 adult patients undergoing coronary artery bypass grafting (CABG)...
  60. ncbi A new non-invasive continuous cardiac output trend solely utilizing routine cardiovascular monitors
    Hironori Ishihara
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Japan
    J Clin Monit Comput 18:313-20. 2004
    Three of the us developed a new non-invasive continuous cardiac output (CCO) measurement method utilizing routine clinical monitors based on the pulse-contour analysis combined with pulse wave transit time (PWTT)...
  61. pmc Cardiac output and sympathetic vasoconstrictor responses during upright tilt to presyncope in healthy humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA
    J Physiol 590:1839-48. 2012
    ..The purpose of this study was to determine the role of cardiac output and sympathetic vasoconstriction in neurally mediated (pre)syncope...
  62. ncbi Cardiac output determination from endotracheally measured impedance cardiography: clinical evaluation of endotracheal cardiac output monitor
    Timothy M Maus
    Thornton Hospital, University of California San Diego, La Jolla, CA 92093 7770, USA
    J Cardiothorac Vasc Anesth 25:770-5. 2011
    To evaluate the accuracy, precision, and trending of a new endotracheally sourced impedance cardiography-based cardiac output (CO) monitor (ECOM; ConMed Corp, Irvine, CA).
  63. ncbi Clonidine lowers blood pressure by reducing vascular resistance and cardiac output in young, healthy males
    Anna Mitchell
    Department of Nephrology, University of Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Cardiovasc Drugs Ther 19:49-55. 2005
    ..study was to determine the hemodynamic response to Clonidine under physiological conditions and to test the hypothesis that Clonidine would reduce cardiac output and blood pressure resulting in an increase in total peripheral resistance.
  64. ncbi Post-prandial blood flow to the gastrointestinal tract is not compromised during hypoxia in the sea bass Dicentrarchus labrax
    Michael Axelsson
    Department of Zoology, University of Goteborg, Sweden
    J Exp Biol 205:2891-6. 2002
    ..blood flow will be reduced during hypoxia to prioritise blood flow to other organs was tested by measuring cardiac output and gut blood flow during a stepwise hypoxic challenge (five steps, from 20.6 to 3...
  65. ncbi Temporary biventricular pacing postcardiopulmonary bypass in patients with reduced ejection fraction
    Jochen D Muehlschlegel
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Card Surg 23:324-30. 2008
    ..This study analyzed the response of BiV versus single ventricle lead pacing on hemodynamics and left ventricular (LV) function immediately following CPB...
  66. ncbi Comparison of the USCOM ultrasound cardiac output monitor with pulmonary artery catheter thermodilution in patients undergoing liver transplantation
    Lai Sze Grace Wong
    Department of Anaesthesiology, Queen Mary Hospital, Hong Kong
    Liver Transpl 14:1038-43. 2008
    The aim of the study was to compare the standard technique of cardiac output determination by pulmonary artery catheter thermodilution (PAC-TD) with a noninvasive ultrasound Doppler monitor (USCOM Pty., Ltd...
  67. ncbi Finapres arterial pulse wave analysis with Modelflow is not a reliable non-invasive method for assessment of cardiac output
    Jaap J Remmen
    Department of Geriatric Medicine, Heartcenter, Department of Cardiology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Sci (Lond) 103:143-9. 2002
    Non-invasive continuous monitoring of cardiac output could be very useful in clinical care and in research settings, particularly in elderly subjects...
  68. ncbi A critical comparison of echocardiographic measurements used for optimizing cardiac resynchronization therapy: stroke distance is best
    Dewi E Thomas
    Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Eur J Heart Fail 11:779-88. 2009
    ..We also assessed the utility of 'stroke distance' [left ventricular outflow tract velocity-time integral (LVOT VTI)] in performing this function...
  69. ncbi Understanding the contribution of Guyton's large circulatory model to long-term control of arterial pressure
    Jean Pierre Montani
    Department of Medicine, Division of Physiology, University of Fribourg, Rue du Musee 5, CH 1700 Fribourg, Switzerland
    Exp Physiol 94:382-8. 2009
    ..of circulatory control, Guyton and colleagues challenged the then prevailing views on how blood pressure and cardiac output were controlled...
  70. ncbi Bevacizumab in patients with hereditary hemorrhagic telangiectasia and severe hepatic vascular malformations and high cardiac output
    Sophie Dupuis-Girod
    Hospices Civils de Lyon, Hopital Louis Pradel, Genetic Department and National Reference Center for Rendu Osler Disease, Bron, France
    JAMA 307:948-55. 2012
    The only treatment available to restore normal cardiac output in patients with hereditary hemorrhagic telangiectasia (HHT) and cardiac failure is liver transplant...
  71. ncbi End-tidal CO2 pressure decreases during exercise in cardiac patients: association with severity of heart failure and cardiac output reserve
    A Matsumoto
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    J Am Coll Cardiol 36:242-9. 2000
    We measured end-tidal CO2 pressure (PETCO2) during exercise and investigated the relationship between PETCO2 and exercise capacity, ventilatory parameters and cardiac output to determine the mechanism(s) of changes in this parameter.
  72. ncbi Acute biventricular pacing after cardiac surgery has no influence on regional and global left ventricular systolic function
    Christoph Schmidt
    Department of Cardiology, Triemli Hospital, Birmensdorferstr 497, 8063 Zurich, Switzerland
    Europace 9:432-6. 2007
    ..determined by tissue Doppler imaging (TDI) and global LV systolic function determined by the continuous cardiac output method were measured during various pacing configurations in patients with depressed LV systolic function ..
  73. ncbi Relationship between aortic-to-radial arterial pressure gradient after cardiopulmonary bypass and changes in arterial elasticity
    Masahiro Kanazawa
    Department of Anesthesiology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Anesthesiology 99:48-53. 2003
    ..To clarify the cause of the pressure gradient after CPB, the authors investigated the relationship between the pressure gradient and changes in the pulse wave velocity (PWV) before and after CPB...
  74. ncbi Cardiac output measurement in children: comparison of the Ultrasound Cardiac Output Monitor with thermodilution cardiac output measurement
    Walter Knirsch
    Division of Pediatric Cardiology, University Children s Hospital, Steinwiesstrasse 75, Zurich, Switzerland
    Intensive Care Med 34:1060-4. 2008
    To compare the assessment of cardiac output (CO) in children using the noninvasive Ultrasound Cardiac Output Monitor (USCOM) with the invasive pulmonary artery catheter (PAC) thermodilution cardiac output measurement.
  75. ncbi Feasibility of cardiac output estimation by ultrasonic cardiac output monitoring in the prehospital setting
    Francois Xavier Duchateau
    Department of Anaesthesiology and Intensive Care, Beaujon University Hospital, Clichy, France
    Eur J Emerg Med 18:357-9. 2011
    The possible benefits of ultrasonic cardiac output monitoring (USCOM) in emergency medicine practice could be significant if evaluated in a goal-directed protocol...
  76. ncbi Global end-diastolic volume during different loading conditions in a pediatric animal model
    Jochen Renner
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Kiel, Germany
    Anesth Analg 105:1243-9, table of contents. 2007
    ..Therefore, we designed the present study to evaluate whether GEDV and PPV are suitable variables of preload and fluid responsiveness during rapidly changing loading conditions in a pediatric animal model...
  77. ncbi Minimally invasive measurement of cardiac output during surgery and critical care: a meta-analysis of accuracy and precision
    Philip J Peyton
    Department of Anaesthesia, Austin Hospital, Melbourne, Australia
    Anesthesiology 113:1220-35. 2010
    When assessing the accuracy and precision of a new technique for cardiac output measurement, the commonly quoted criterion for acceptability of agreement with a reference standard is that the percentage error (95% limits of agreement/mean ..
  78. ncbi Dynamic preload indicators fail to predict fluid responsiveness in open-chest conditions
    Eric E C de Waal
    Division of Perioperative and Emergency Care, University Medical Center, Utrecht, The Netherlands
    Crit Care Med 37:510-5. 2009
    ..However, in open-chest conditions, the value of these indices has not been systematically examined yet. We, therefore, evaluated the ability of PPV and SVV to predict fluid responsiveness under open- and closed-chest conditions...
  79. ncbi Heart stroke volume, cardiac output, and ejection fraction in 265 normal fetus in the second half of gestation assessed by 4D ultrasound using spatio-temporal image correlation
    Christiane Simioni
    Department of Obstetrics, Sao Paulo Federal University UNIFESP, Sao Paulo, Brazil
    J Matern Fetal Neonatal Med 24:1159-67. 2011
    The aim of this study was to establish nomograms for fetal stroke volume (SV), cardiac output (CO), and ejection fraction (EF) using four-dimensional ultrasound with spatio-temporal image correlation (STIC) modality.
  80. ncbi Assessing the diagnostic accuracy of pulse pressure variations for the prediction of fluid responsiveness: a "gray zone" approach
    Maxime Cannesson
    Department of Anesthesiology and Perioperative Care, School of Medicine, University of California, Irvine, Irvine, California, USA
    Anesthesiology 115:231-41. 2011
    ..The authors sought to test the predictive value of PPV in a large, multicenter study and to express it using a gray zone approach...
  81. ncbi Impact of pacing modality and biventricular pacing on cardiac output and coronary conduit flow in the post-cardiotomy patient
    David G Healy
    Department of Cardiothoracic Surgery, Cork University Hospital, Wilton, Cork, Ireland
    Interact Cardiovasc Thorac Surg 7:805-8. 2008
    ..Comparison of cardiac output and coronary conduit flow was performed between VVI and DDD pacing with a single right ventricular lead and ..
  82. pmc Muscle oxygen transport and utilization in heart failure: implications for exercise (in)tolerance
    David C Poole
    Departments of Anatomy and Physiology, and Kinesiology, Kansas State University, Manhattan, KS 66506 5802, USA
    Am J Physiol Heart Circ Physiol 302:H1050-63. 2012
    ..As the heart fails, cardiovascular regulation shifts from controlling cardiac output as a means for supplying the oxidative energetic needs of exercising skeletal muscle and other organs to ..
  83. ncbi Pre-ejection period variations predict the fluid responsiveness of septic ventilated patients
    Marc Feissel
    Intensive Care Unit, Centre Hospitalier, Belfort, France
    Crit Care Med 33:2534-9. 2005
    ..We hypothesized that the respiratory change in pre-ejection period (DeltaPEP) would allow the prediction of changes in cardiac index following volume administration in mechanically ventilated septic patients...
  84. ncbi Interrater reliability of cardiac output measurements by transcutaneous Doppler ultrasound: implications for noninvasive hemodynamic monitoring in the ED
    H Bryant Nguyen
    Department of Emergency Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    Am J Emerg Med 24:828-35. 2006
    ..The purpose of this study is to investigate the interrater agreement of noninvasive cardiac output measurements using transcutaneous Doppler ultrasound technique.
  85. ncbi USCOM (Ultrasonic Cardiac Output Monitors) lacks agreement with thermodilution cardiac output and transoesophageal echocardiography valve measurements
    H L A Van den Oever
    Department of Anaesthesia, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Anaesth Intensive Care 35:903-10. 2007
    The USCOM (Ultrasonic Cardiac Output Monitors) device is a non-invasive cardiac output monitor, which utilises transaortic or transpulmonary Doppler flow tracing and valve area estimated using patient height to determine cardiac output...
  86. ncbi Clinical validation of the non-invasive cardiac output monitor USCOM-1A in critically ill patients
    L E M van Lelyveld-Haas
    Gelderse Vallei Hospital, Department of Intensive Care, Ede, Nijmegen, The Netherlands
    Eur J Anaesthesiol 25:917-24. 2008
    b>Cardiac output is frequently monitored to maintain and improve cardiac function with the primary goal of adequate tissue perfusion...
  87. ncbi Sublingual nitroglycerin used in routine tilt testing provokes a cardiac output-mediated vasovagal response
    Janneke Gisolf
    Department of Physiology, Academic Medical Center, Cardiovascular Research Institute, Amsterdam, The Netherlands
    J Am Coll Cardiol 44:588-93. 2004
    ....
  88. ncbi Cardiac output monitoring in newborns
    Willem Pieter de Boode
    Radboud University Nijmegen Medical Centre, Department of Neonatology, Nijmegen, The Netherlands
    Early Hum Dev 86:143-8. 2010
    There is an increased interest in methods of objective cardiac output measurement in critically ill patients. Several techniques are available for measurement of cardiac output in children, although this remains very complex in newborns...
  89. ncbi Comparison of pulmonary artery and aortic transpulmonary thermodilution for monitoring of cardiac output in patients with severe heart failure: validation of a novel method
    Sigrun Friesecke
    Department of Internal Medicine B, Division of Cardiology, Pneumology, and Critical Care Medicine, University of Greifswald, Greifswald, Germany
    Crit Care Med 37:119-23. 2009
    ..For measurement of cardiac output (CO), transpulmonary thermodilution (TPTD) has recently been adopted into clinical practice as an alternative ..
  90. pmc Arterial pressure-based cardiac output in septic patients: different accuracy of pulse contour and uncalibrated pressure waveform devices
    Xavier Monnet
    AP HP, Hopital de Bicetre, Service de Reanimation Medicale, 78 rue du General Leclerc, Le Kremlin Bicêtre F 94270, France
    Crit Care 14:R109. 2010
    We compared the ability of two devices estimating cardiac output from arterial pressure-curve analysis to track the changes in cardiac output measured with transpulmonary thermodilution induced by volume expansion and norepinephrine in ..
  91. ncbi Cardiac output derived from arterial pressure waveform
    Jochen Mayer
    Department of Anesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Ludwigshafen, Germany
    Curr Opin Anaesthesiol 22:804-8. 2009
    b>Cardiac output (CO) and other flow-based hemodynamic variables have become increasingly important to guide treatment of patients undergoing major surgery with expected fluid shifts in the operating room as well as critically ill ICU ..
  92. ncbi Testing the reliability of a new ultrasonic cardiac output monitor, the USCOM, by using aortic flowprobes in anesthetized dogs
    Lester A Critchley
    Department of Anesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China
    Anesth Analg 100:748-53, table of contents. 2005
    We have used an animal model to test the reliability of a new portable continuous-wave Doppler ultrasonic cardiac output monitor, the USCOM...
  93. ncbi Comparison of cardiac output determined by bioimpedance, thermodilution, and the Fick method
    Milo Engoren
    Department of Anesthesiology, St Vincent Mercy Medical Center, Toledo, OH, USA
    Am J Crit Care 14:40-5. 2005
    b>Cardiac output can be determined by using a variety of methods.
  94. pmc Cross-comparison of cardiac output trending accuracy of LiDCO, PiCCO, FloTrac and pulmonary artery catheters
    Mehrnaz Hadian
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 230 Lothrop Street, Pittsburgh, PA 15261, USA
    Crit Care 14:R212. 2010
    ..invasive than pulmonary artery catheters (PACs), arterial pulse pressure analysis techniques for estimating cardiac output (CO) have not been simultaneously compared to PAC bolus thermodilution CO (COtd) or continuous CO (CCO) devices...
  95. ncbi Comparison of continuous cardiac output measurements in patients after cardiac surgery
    Frank Mielck
    Departments of Anesthesiology, and Medical Statistics, University of Goettingen, Germany
    J Cardiothorac Vasc Anesth 17:211-6. 2003
    To investigate in a direct comparison accuracy and precision of continuous cardiac output measurements assessed by continuous pulmonary artery thermodilution technique (TDCCO), continuous pulse contour analysis (PCCO), and noninvasive ..
  96. ncbi Measurement of cardiac output before and after cardiopulmonary bypass: Comparison among aortic transit-time ultrasound, thermodilution, and noninvasive partial CO2 rebreathing
    Monica Botero
    Department of Anesthesiology, University of Florida College of Medicine and the Gainesville Veterans Affairs Medical Center, Gainesville, FL, USA
    J Cardiothorac Vasc Anesth 18:563-72. 2004
    A noninvasive continuous cardiac output system (NICO) has been developed recently...
  97. ncbi Echocardiographic measurement of cardiac output in rats
    Michel Slama
    Laboratoire de Pharmacologie et de Physiopathologie Cardiovasculaire, Faculte de Medecine, Université de Picardie Jules Vernes, 80054 Amiens, France
    Am J Physiol Heart Circ Physiol 284:H691-7. 2003
    The systematic evaluation of different transthoracic echocardiographic (TTE) methods to determine cardiac output (CO) and the effect of changes in intravascular volume on echocardiographically determined indexes of cardiovascular ..
  98. ncbi Effects of vasodilation on cardiac output measured by PulseCO
    Koichi Yamashita
    Department of Anesthesiology and Critical Care Medicine, Kochi Medical School, Kohasu, Oko cho, Nankoku Shi, Kochi, 783 8505, Japan
    J Clin Monit Comput 21:335-9. 2007
    The instability of cardiac output (CO) measured by PulseCO (LiDCO Ltd.) during cardiac surgery has been reported...
  99. pmc Lower cardiac output is associated with greater white matter hyperintensities in older adults with cardiovascular disease
    Angela L Jefferson
    Department of Neurology, Alzheimer s Disease Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Am Geriatr Soc 55:1044-8. 2007
    To preliminarily examine the association between cardiac output, a measure of systemic blood flow, and structural brain magnetic resonance imaging indices of white matter hyperintensities (WMHs).
  100. ncbi Measurement of cardiac output: a comparison between transpulmonary thermodilution and uncalibrated pulse contour analysis
    S G Sakka
    Department of Anaesthesiology and Operative Intensive Care Medicine, Medical Center Cologne Merheim, Cologne, Germany
    Br J Anaesth 99:337-42. 2007
    Recently, continuous monitoring of cardiac output (CO) based on pulse contour analysis (Vigileo) has been introduced into practice...
  101. pmc Arterial pressure-based cardiac output monitoring: a multicenter validation of the third-generation software in septic patients
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium
    Intensive Care Med 37:233-40. 2011
    Second-generation FloTrac software has been shown to reliably measure cardiac output (CO) in cardiac surgical patients. However, concerns have been raised regarding its accuracy in vasoplegic states...

Research Grants74

  1. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ..is heightened sympathetic nervous system activity stemming from repetitive apneic events, although falls in cardiac output that accompany large negative intrathoracic pressure swings, and repetitive hypoxia/reoxygenation associated ..
  2. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    Patrice G Guyenet; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: A brief period of asphyxia activates breathing, blood pressure and the cardiac output. Asphyxia also produces arousal from sleep which enables corrective behavior for example in case of airway ..
  3. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..true in those conditions that require a high level of sympathetic tone to compensate for an abnormal cardiac output or where sympathetic nervous activity sustains arterial pressure in a range that is clearly detrimental to ..
  4. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..the rest of the body thereby a) significantly enhancing blood return to the heart and consequently increasing cardiac output and blood pressure and b) uniquely lowering intracranial pressure thereby increasing cerebral perfusion...
  5. Mechanisms of Vasovagal Syncope
    Julian M Stewart; Fiscal Year: 2013
    ..apply this mechanism to a model of orthostatic stress, lower body negative pressure (LBNP), while measuring cardiac output by inert gas rebreathing, regional blood volume, and regional blood flow using plethysmographic techniques ..
  6. Respiratory motor control and blood pressure regulation after spinal cord injury
    ALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2013
    ..of managing their unstable blood pressure which frequently results in persistent hypotension due to decreased cardiac output and autonomic nervous system dysfunction...
  7. Molecular control of differential peptide transmitter exocytosis.
    COREY B SMITH; Fiscal Year: 2013
    ..multiple processes that prepare for defense or escape, including generalized analgesia (enkephalin), increased cardiac output (elevated catecholamines), blood flow to skeletal muscle (atrial natriuretic factor, Neuropeptide Y) and blood ..
  8. Monitoring of Cardiovascular Function in Infants By Transcutaneous Dye Dilution
    Istvan Seri; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cardiac output (CO) and measures of cardiac preload (central blood volume, CBV) and systemic vascular resistance (SVR) are critical clinical parameters of circulatory function...
  9. Peptide Therapy for Pulmonary Arterial Hypertension
    Jawaharlal M Patel; Fiscal Year: 2013
    ..increased pulmonary vascular resistance, vascular remodeling, right ventricular (RV) failure, and low cardiac output. Despite its profound clinical consequences, therapeutic advances over the past 25 years have modestly ..
  10. Novel non-invasive device for treatment of elevated intracranial pressures
    Keith G Lurie; Fiscal Year: 2011
    ..relative to the rest of the body thereby a) enhancing blood return to the heart and consequently increasing cardiac output and blood pressure and b) lowering intracranial pressure thereby increasing cerebral perfusion...
  11. Novel bundled mechanical and pharmacological CPR platform
    Anja Metzger; Fiscal Year: 2012
    ..within the thorax relative to the rest of the body that enhances venous blood return to the heart, increases cardiac output and systemic arterial blood pressure, lowers right atrial and pulmonary artery pressures, lowers intracranial ..
  12. L-arginine supplement for the prevention of calcineurin inhibitor nephrotoxicity
    W Ray Kim; Fiscal Year: 2011
    ..Additionally, the effects of oral L-arginine on glomerular filtration rate, cardiac output, systemic vascular resistance, endothelial function, plasma arginine level and urinary cyclic-GMP will be ..
  13. Resuscitation using novel impedance threshold devices in pediatrics
    Keith G Lurie; Fiscal Year: 2013
    ..pressure regulation (IPR), enhances negative intrathoracic pressure and thus will augment preload, improve cardiac output, enhance cerebral oxygenation, and delay or prevent the progression of reversible shock to irreversible ..
  14. Free Hemoglobin Potentiates Pulmonary Vascular Dysfunction in Acute Lung Injury
    JULIE ANNE BASTARACHE; Fiscal Year: 2013
    ..pressure, pulmonary vascular resistance, transpulmonary resistance), cardiac dysfunction (as measured by cardiac output and mixed venous oxygen saturation), non-pulmonary organ dysfunction, and biomarkers of endothelial injury and ..
  15. Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)
    R Graham Barr; Fiscal Year: 2011
    ..We found impaired endothelial function and reduced cardiac output with preserved LV function in early COPD among smokers in two cohort studies, the EMCAP Study and the Multi-..
  16. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2013
    ..of airflow obstruction and emphysema on CT scan with reduced LV end-diastolic volume, LV stroke volume and cardiac output but not LV-EF on magnetic resonance imaging, particularly among smokers...
  17. Mechanisms of Meditation in Hypertension in Blacks
    Robert Schneider; Fiscal Year: 2010
    ..reactivity to lab stressors;hemodynamic responses, comprising heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance;arterial compliance, and cardiac autonomic nervous system tone using heart ..
  18. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    JAMES FARLEY WALTON; Fiscal Year: 2010
    ..controller are its ability to use motor and magnetic bearing signals to adjust LVAD output in response to cardiac output changes through the use of differential pressure and flow estimators all while avoiding suction...
  19. Genetic Regulation of Metabolic and Fibrotic Programs in Hypertrophic Heart
    M A Q Siddiqui; Fiscal Year: 2013
    ..to stress and increased demand by mounting an adaptive or compensatory hypertrophic response to normalize cardiac output. With prolonged stress, this adaptive phase devolves to a maladaptive or decompensatory hypertrophy marked by ..
  20. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John H Eisenach; Fiscal Year: 2012
    ..for glycine at position 16 (Gly16) and glutamate at position 27 (Glu27) (haplotype 1) will demonstrate greater cardiac output and lower systemic vascular resistance during mental stress and isometric handgrip exercise than individuals ..
  21. Neurohumoral control of veins in hypertension
    Gregory D Fink; Fiscal Year: 2013
    ..rats using a number of whole body measures including blood pressure, mean circulatory filling pressure, cardiac output, and fluid volume distribution using bioimpedance...
  22. Excitability of afferents evoking the exercise pressor reflex
    Victor Ruiz-Velasco; Fiscal Year: 2013
    ..increasing blood flow and oxygen to exercising muscles, include reflex increases in arterial blood pressure, cardiac output and ventilation...
  23. The role of cochlear pericytes in control of cochlear microcirculation
    Xiao Rui Shi; Fiscal Year: 2009
    ..The volume of cochlear blood flow is extremely small (on the order of 1/1 000 000 of total cardiac output), yet critically important for normal hearing...
  24. Nuclear magnetic Tirho relaxation in acute and chronic myocardial infarctions
    Walter R T Witschey; Fiscal Year: 2013
    ..Ultimately, cardiac output cannot be sustained under such progressive heart enlargement...
  25. Physiological reactivity to acute stress during pregnancy
    LISA MICHELLE CHRISTIAN; Fiscal Year: 2010
    ..e., cardiac output, total peripheral resistance)...
  26. Effects of maternal cortisol on fetal and neonatal growth and metabolism
    Maureen Keller-Wood; Fiscal Year: 2013
    ..growth and metabolism primarily by reducing maternal volume expansion, and the normal increases in maternal cardiac output and uteroplacental blood flow that are essential for acceleration of fetal growth in the late gestation, and ..
  27. Perinatal regulation of endothelial NOS
    Stephen M Black; Fiscal Year: 2010
    ..and much of our therapies are focused on altering pulmonary vascular resistance in attempt to optimize cardiac output while maintaining enough pulmonary blood flow to ensure adequate systemic oxygenation...
  28. Circulatory system and integrated muscle tissue for drug and tissue toxicity
    George A Truskey; Fiscal Year: 2013
    ..Skeletal muscle is important for drug and toxicity testing given the relative size of the muscle mass and cardiac output that passes through muscle beds, the key role of muscle in energy substrate metabolism and diabetes, its role ..
  29. Mechanisms of Cardiac Function and Cerebral Vascular Control during Heat Stress
    Robert Matthew Brothers; Fiscal Year: 2010
    ..Specifically we will examine: 1) the role of decreased central venous pressure and cardiac output during combined heat and orthostatic stress on CBF, 2) the relative contributions of reduced arterial CO2 ..
  30. Frequency-dependent modulation of cardiac myofilament function in health/disease
    PAULUS ML JANSSEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Maintenance of sufficient cardiac output to provide the body and the heart itself with nutrients and oxygen is a must to sustain life...
  31. Improving the Kinetics and Reliability of Continuous Glucose Monitoring
    Brett D Mensh; Fiscal Year: 2012
    ..because the blood flow to this central, protected space is copious and robust to changes in temperature and cardiac output, and because the glucose kinetics of the peritoneal space are known to be fast...
  32. CARDIAC CONTRACTILE KINETICS
    Michael Regnier; Fiscal Year: 2009
    ..a mechanism for greater cellular level contractile control that is required for beat-to-beat regulation of cardiac output. Direct evidence to support this idea is difficult to obtain, in part due to an inability to alter crossbridge ..
  33. A novel device for improving sepsis outcomes through hemodynamic optimization
    Brett D Mensh; Fiscal Year: 2013
    ..to monitor patient responses to fluid infusion, particularly those that can safely and accurately measure cardiac output or detect the onset of fluid overload. In response to this need we have developed the OmniSense catheter...
  34. Entrainment-based mechanical ventilation
    Chi Sang Poon; Fiscal Year: 2010
    ..work of breathing and risk of barotrauma, as well as decreases in pulmonary gas exchange efficiency and in cardiac output. Current generation of mechanical ventilators either control the breathing rhythm completely independent of ..
  35. The Stress of Chronic Disease: Mineralocorticoid Mediation of Mood
    Alan Kim Johnson; Fiscal Year: 2013
    ..lead us to hypothesize that adrenal mineralocorticoids released in the course of attempting to maintain the cardiac output of a failing heart are depressivogenic through their action on the central nervous system...
  36. Preoperative Therapy for Prevention of Postoperative Low Cardiac Output Syndrome
    D Woodrow Benson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Myocardial dysfunction and resulting low cardiac output syndrome (LCOS) contribute significantly to postoperative morbidity and mortality in pediatric heart surgery...
  37. mAKAP-orchestrated phosphorylation events: regulation of PDE4D3
    Kimberly L Dodge Kafka; Fiscal Year: 2010
    ..is the major compensatory mechanism by which the heart responds to a continued, increased demand for cardiac output. Ultimately, cardiac hypertrophy leads to progression into cardiac disease and to heart failure...
  38. RSK Regulation of NFATc and Cardiac Myocyte Hypertrophy
    Alejandra Negro; Fiscal Year: 2010
    ..Although cardiac hypertrophy can maintain cardiac output in response to elevated wall stress, sustained cardiac hypertrophy is often accompanied by maladaptive ..
  39. Na+/Ca2+ Exchanger type-1 in Arterial Contraction and Salt-induced Hypertension
    Jin Zhang; Fiscal Year: 2013
    ..Blood flow (to determine cardiac output, CO) and telemetric arterial BP will be measured in conscious, freely moving mice...
  40. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1992
    ..Arterial and venous blood gases, cardiac output and ECG will be monitored. PH, blood lactate and glucose will also be measured...
  41. Inflammatory response of aging heart to surgical myocardial ischemia
    Xianzhong Meng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Elderly patients are vulnerable to low cardiac output syndrome after cardiac surgery that obligates global myocardial ischemia and reperfusion (I/R)...
  42. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ..Central hypovolemia causes decreased cardiac output, reflex tachycardia and reduced cerebral blood flow...
  43. Multimodal biophysical markers of vascular disease in hemoglobinopathies
    Lonnie K Zeltzer; Fiscal Year: 2013
    ..varying percent hemoglobin S in order to separate the measurement components due to altered blood rheology and cardiac output from the components reflecting vascular status and the autonomic function of interest...
  44. Effects of Mechanical Unloading on Myocardial Function and Structure in Humans
    Josef Stehlik; Fiscal Year: 2013
    ..LVADs are used as a bridge to transplant or as permanent therapy. The benefits of restoring normal cardiac output through LVAD support are well described, but our understanding of the effects and possible consequences of ..
  45. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..thorax relative to the rest of the body thereby a) enhancing venous blood return to the heart b) increasing cardiac output and systemic arterial blood pressure, c) lowering right atrial and pulmonary artery pressures, and d) lowering ..
  46. Ethanol on Excitation-Contraction in Cardiac Cells
    Andrew Thomas; Fiscal Year: 2009
    ..Features of alcoholic cardiomyopathy include decreased cardiac output, impaired myocardial contractility and atrial dysrhythmias...
  47. Randomized Clinical Trials for Pediatric Heart Disease
    J Philip Saul; Fiscal Year: 2010
    ..the effects of preoperative intravenous methypredisolone (IVMP) to placebo on the Primary Endpoint of low cardiac output state (LCOS) or death at 36 hours following neonatal CPB...
  48. Skeletal Muscle Basis for Improved Exercise Endurance in AC5 KO
    Stephen F Vatner; Fiscal Year: 2013
    ..major goals of physicians treating patients with cardiovascular disease, can be achieved either by improving cardiac output and blood flow to skeletal muscle, or by improving energy metabolism in skeletal muscle, or both...
  49. Engineered Induction of a Stem Cell Homing Response
    JEFFREY MICHAEL KARP; Fiscal Year: 2013
    ..with an exogenous cell source) natural stem cell homing mechanisms show promise to preserve and restore cardiac output following myocardial infarction...
  50. Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI
    Bastiaan Driehuys; Fiscal Year: 2013
    ..blood-selective 129Xe gas exchange MRI 2) Establish image reproducibility as a function of time, posture, and cardiac output, and 3) Image the temporal evolution of regional gas exchange during radiation therapy...
  51. Exercise adaptations in mitochondrial myopathy: therapeutic implications
    Ronald G Haller; Fiscal Year: 2012
    ..effects on muscle and cardiovascular function will be assessed by monitoring peak work, oxygen utilization, cardiac output and stroke volume in cycle exercise, and by monitors of quality of life...
  52. Compliant Thoracic Artificial Lungs
    KEITH ELLIOT COOK; Fiscal Year: 2012
    ..work also indicates that the fluid mechanical impedance of these devices can cause a significant reduction in cardiac output (CO) when attached in the PA- PA configuration...
  53. Mechanism for Regulation of Phospholipase C by G Protein
    Alan V Smrcka; Fiscal Year: 2013
    ..One of the characteristics of progression to heart failure is reduced cardiac output due to decreased contractility and cardiac hypertrophy...
  54. Rescue of Beta-Adrenergic Cardiomyopathy by Inhibition of Adenylyl Cyclase
    Dorothy E Vatner; Fiscal Year: 2012
    ..Tg cardiomyopathies by inhibition of AC5 permits enhanced exercise performance which is due to (1) improved cardiac output and stroke volume, (2) improved coronary reserve, and (3) enhanced nitric oxide (NO) signaling...
  55. Long Term Treatment of Modified Stem Cells for Pulmonary Hypertension
    DAVID BRENDAN CASEY; Fiscal Year: 2010
    ..is to investigate the effect of unmodified and gene modified MSCs on pulmonary arterial and wedge pressure and cardiac output and on pulmonary vasodilator response to acetylcholine for periods up to 6 months after moncrotaline ..
  56. Remote and non-invasive continuous cardiopulmonary monitoring using low-power FM
    KIRILL S contact MOSTOV; Fiscal Year: 2010
    ..radar (MFMR) can detect changes in the following four physiological variables: heart rate, respiratory rate, cardiac output and respiratory tidal volume...
  57. The role of RGS proteins in the parasympathetic control of heart rate
    KEVIN D WICKMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cardiac output adjusts on a beat-to-beat basis due to the changing balance of parasympathetic and sympathetic input to the heart. G protein signaling pathways are fundamental to this important process...
  58. CARDIAC HYPERTROPHIC INTRACELLULAR SIGNALING PATHWAYS
    Jeffrey Robbins; Fiscal Year: 2013
    ..While hypertrophy can initially be a compensatory response that temporarily augments cardiac output, prolonged hypertrophy can be deleterious and eventually leads to heart failure and/or sudden death...
  59. Ca2+/CaM-Dependent Protein Kinase II: A Novel Target in Heart Failure
    Howard Schulman; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Heart disease converts to the clinical syndrome of heart failure when the cardiac output is inadequate to meet metabolic requirements...
  60. Role of the Molecular Circadian Clock within the Heart
    MARTIN ELLIOT YOUNG; Fiscal Year: 2012
    ..Humans exhibit marked circadian rhythms in multiple cardiovascular (CV) parameters, including heart rate, cardiac output, and blood pressure...
  61. Abnormal Intracellular Calcium Release in Heart Failure
    Sandor Gyorke; Fiscal Year: 2013
    ..is an increasingly prevalent disease that occurs when the cardiac muscle is unable to maintain a sufficient cardiac output. HF patients suffer, and eventually die from either progressive failure of cardiac mechanical function (pump ..
  62. The Effects of Perceived Discrimination on Mental and Physical Health
    BRENDA N MAJOR; Fiscal Year: 2010
    ..g., vascular resistance) or anger (e.g., cardiac output)...
  63. PITCH HF Right Ventricular Pulmonary Vascular Reserve Ancillary Study
    GREGORY DYER LEWIS; Fiscal Year: 2013
    ..study is that abnormal pulmonary vasodilatory capacity, as reflected by steep PAP increment relative to cardiac output (i.e...
  64. BAROREFLEX AND POSTERIOR HYPOTHALAMIC NEUROPEPTIDE-Y
    John Martin; Fiscal Year: 1991
    ..The animals used in these experiments will be instrumented so that cardiac output can be simultaneously measured in order to determine the effect of sympathetic and/or parasympathetic activity ..
  65. SURGICAL STUDIES OF SEVERE RESPIRATORY FAILURE
    Joseph Zwischenberger; Fiscal Year: 2004
    ..Adverse effects of permissive hypercapnia and the associated respiratory acidosis include increased cardiac output, organ blood flow and intracranial pressure...
  66. Effects of Vasoactive Drugs on Perfusion in Septic Shock
    Patrick Murray; Fiscal Year: 2005
    ..may lead to refractorv hypotension (septic shock) and multiple organ system failure (MOSF). Despite increased cardiac output and oxygen delivery, death often ensues from refractory hypotension or subsequent MOSF...
  67. COMPLEMENT-DEPENDENT PROSTAGLANDIN SYNTHESIS IN SEPSIS
    Mitchell Fink; Fiscal Year: 1991
    ..will employ a rabbit model of endotoxemia that is characterized by low systemic vascular resistance and high cardiac output; i.e., the model satisfactorily replicates the systemic hemodynamic profile of human sepsis...
  68. NO Metabolic Control in Pregnancy
    Thomas Hintze; Fiscal Year: 2006
    The cardiovascular adjustments that occur during pregnancy include chronic increases in cardiac output, falls in total peripheral vascular resistance and tachycardia...
  69. TRANSFUSION TRIGGER EXTENSION BY PLASMA EXPANDERS
    Marcos Intaglietta; Fiscal Year: 2009
    ..These effects occur also in the microcirculation of the heart, causing heart function, and cardiac output to decrease...
  70. LUNG VASCULAR EFFECTS OF HIGH FREQUENCY VENTILATION
    MUKUL BANERJEE; Fiscal Year: 1992
    ..substances, eicosanoids and atrial natriuretic factor (ANF) are released during substances can influence cardiac output, pulmonary and systemic vascular pressures and water balance...
  71. PHYSIOLOGIC RESPONSE TO THERMAL INJURY
    EDWARD PAVLIN; Fiscal Year: 1990
    Victims of thermal injury undergo profound physiologic changes; e.g. increases in basal metabolic rate, cardiac output and glomerular filtration rate...
  72. ADAPTATIONS TO EXERCISE IN OLDER HYPERTENSIVE SUBJECTS
    Ali Ehsani; Fiscal Year: 2000
    ..exercise-training can reduce BP; (2) to elucidate mechanisms underlying reduction of BP by evaluation of cardiac output, total peripheral resistance, arterial stiffness, sympathetic nervous system activity, and blood volume; (3) ..
  73. Neural and non-neural modulators of skin blood flow and sweating in humans
    CRAIG CRANDALL; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): A large fraction of cardiac output (i.e...
  74. Mechanisms Mediating Hypotension to Anthrax Lethal Toxin
    Michael J Kenney; Fiscal Year: 2010
    ..sympathetic nerve outflow, the fundamental link between central sympathetic neural circuits and regulation of cardiac output, vascular resistance, and arterial blood pressure...