heart function tests

Summary

Top Publications

  1. ncbi Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations
    Miho Kawaguchi
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circulation 107:714-20. 2003
  2. ncbi Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome
    Kevin A Bybee
    Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Cardiol 94:343-6. 2004
  3. ncbi Impairment of left ventricular function in systemic lupus erythematosus evaluated by measuring myocardial performance index with tissue Doppler echocardiography
    Federico Cacciapuoti
    Division of Internal Medicine and Metabolic Disease, Second University of Naples, Naples, Italy
    Echocardiography 22:315-9. 2005
  4. ncbi Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects: Hypertension Genetic Epidemiology Network (HyperGEN) study
    V Palmieri
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Circulation 103:102-7. 2001
  5. ncbi Dose-dependent effects of intravenous allogeneic mesenchymal stem cells in the infarcted porcine heart
    David Wolf
    Department of Cardiology, University of Heidelberg, Koesching, Germany
    Stem Cells Dev 18:321-9. 2009
  6. ncbi Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction
    Violaine Carpenter
    Waikato Clinical School, Private Bag 3200, Hamilton, New Zealand
    Heart Lung Circ 17:33-9. 2008
  7. ncbi New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function
    Michael R Zile
    Division of Cardiology, Department of Medicine, Medical University of South Carolina, The Gazes Cardiac Research Institute and the Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    Circulation 105:1387-93. 2002
  8. ncbi CD36 expression contributes to age-induced cardiomyopathy in mice
    Debby P Y Koonen
    Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Circulation 116:2139-47. 2007
  9. ncbi Time course of sympathetic neural hyperactivity after uncomplicated acute myocardial infarction
    Lee N Graham
    Department of Cardiology, St James s University Hospital, Leeds, UK
    Circulation 106:793-7. 2002
  10. ncbi The impact of metabolic syndrome on left ventricular function: evaluated by using the index of myocardial performance
    Hasan Turhan
    Department of Cardiology, Inonu University Faculty of Medicine, Malatya Turkey
    Int J Cardiol 132:382-6. 2009

Research Grants

  1. Oxidative Stress in Sleep Apnea and Cardiac Disease
    Reena Mehra; Fiscal Year: 2010
  2. LONG QT SYNDROME--GENETIC STUDIES
    Arthur Moss; Fiscal Year: 2002
  3. THERAPUTIC TRIAL IN PATIENTS WITH LQTS 3 GENE MUTATION
    Arthur Moss; Fiscal Year: 2002
  4. Obesity and Surgical Outcomes
    Jeffrey H Silber; Fiscal Year: 2010
  5. ACTION - A CHF Trial Investigating Outcomes of Exercise
    Steven Keteyian; Fiscal Year: 2007
  6. THROMBOGENIC FACTORS AND RECURRENT CORONARY EVENTS
    Arthur Moss; Fiscal Year: 2003
  7. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
  8. CONDITIONAL LENGTH OF STAY: A PEDIATRICS OUTCOME MEASURE
    JEFFREY SILBER; Fiscal Year: 2001
  9. Adenosine Receptor-Mediated Protection in Reperfused MI
    George Beller; Fiscal Year: 2008
  10. Patient Oriented Research in Pediatric Nutrition
    Nancy Krebs; Fiscal Year: 2008

Detail Information

Publications241 found, 100 shown here

  1. ncbi Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations
    Miho Kawaguchi
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circulation 107:714-20. 2003
    ..We hypothesized that such patients also display combined ventricular-systolic and arterial stiffening that can exacerbate blood pressure lability and diastolic dysfunction under stress...
  2. ncbi Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome
    Kevin A Bybee
    Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Cardiol 94:343-6. 2004
    ..TIMI frame counts were abnormal in all patients and often abnormal in all 3 major coronary vessels, suggesting that the diffuse impairment of coronary microcirculatory function may play a role in the pathogenesis of the syndrome...
  3. ncbi Impairment of left ventricular function in systemic lupus erythematosus evaluated by measuring myocardial performance index with tissue Doppler echocardiography
    Federico Cacciapuoti
    Division of Internal Medicine and Metabolic Disease, Second University of Naples, Naples, Italy
    Echocardiography 22:315-9. 2005
    ..TDE is more precise than the conventional Doppler method in evaluating MPI and single time intervals, because their measurements are accomplished in concomitance of left ventricular wall motion rather than the flow movement...
  4. ncbi Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects: Hypertension Genetic Epidemiology Network (HyperGEN) study
    V Palmieri
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Circulation 103:102-7. 2001
    ..It remains to be elucidated in a large, population-based sample whether diabetes is associated with changes in left ventricular (LV) structure and systolic function independent of obesity and systolic blood pressure (BP)...
  5. ncbi Dose-dependent effects of intravenous allogeneic mesenchymal stem cells in the infarcted porcine heart
    David Wolf
    Department of Cardiology, University of Heidelberg, Koesching, Germany
    Stem Cells Dev 18:321-9. 2009
    ..Therefore, intravenously administration of MSCs is an attractive minimal-invasive approach for cardiac tissue repair...
  6. ncbi Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction
    Violaine Carpenter
    Waikato Clinical School, Private Bag 3200, Hamilton, New Zealand
    Heart Lung Circ 17:33-9. 2008
    ..Our objective was to determine if MGF would reduce the area of 'at-risk' myocardium and improve cardiac function in the post-infarct heart...
  7. ncbi New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function
    Michael R Zile
    Division of Cardiology, Department of Medicine, Medical University of South Carolina, The Gazes Cardiac Research Institute and the Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    Circulation 105:1387-93. 2002
  8. ncbi CD36 expression contributes to age-induced cardiomyopathy in mice
    Debby P Y Koonen
    Cardiovascular Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Circulation 116:2139-47. 2007
    ..Although vascular abnormalities associated with aging contribute to the age-related decline in cardiac function, myocardium-specific events may also be involved...
  9. ncbi Time course of sympathetic neural hyperactivity after uncomplicated acute myocardial infarction
    Lee N Graham
    Department of Cardiology, St James s University Hospital, Leeds, UK
    Circulation 106:793-7. 2002
    ..We planned to quantify central sympathetic output to the periphery after uncomplicated AMI and to investigate its progress over time...
  10. ncbi The impact of metabolic syndrome on left ventricular function: evaluated by using the index of myocardial performance
    Hasan Turhan
    Department of Cardiology, Inonu University Faculty of Medicine, Malatya Turkey
    Int J Cardiol 132:382-6. 2009
    ..To evaluate the impact of metabolic syndrome on global left ventricular function by using the index of myocardial performance...
  11. ncbi Cardiac output derived from arterial pressure waveform analysis in patients undergoing cardiac surgery: validity of a second generation device
    Jochen Mayer
    Department of Anesthesiology and Intensive Care Medicine, Klinikum Ludwigshafen, Bremserstr 79, 67063 Ludwigshafen, Germany
    Anesth Analg 106:867-72, table of contents. 2008
    ..We designed the present study to assess the validity of an improved version of this monitoring technique compared with intermittent thermodilution CO measurement using a pulmonary artery catheter in patients undergoing cardiac surgery...
  12. ncbi Does microvolt T-wave alternans testing predict ventricular tachyarrhythmias in patients with ischemic cardiomyopathy and prophylactic defibrillators? The MASTER (Microvolt T Wave Alternans Testing for Risk Stratification of Post-Myocardial Infarction Pat
    Theodore Chow
    Lindner Clinical Trial Center at The Christ Hospital, Cincinnati, Ohio 45219, USA
    J Am Coll Cardiol 52:1607-15. 2008
    ..The purpose of this trial was to determine whether microvolt T-wave alternans (MTWA) predicts ventricular tachyarrhythmic events (VTEs) in post-myocardial infarction patients with left ventricular ejection fraction (LVEF) < or =30%...
  13. ncbi A meta-analysis of studies using bias and precision statistics to compare cardiac output measurement techniques
    L A Critchley
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    J Clin Monit Comput 15:85-91. 1999
    ..Bias and precision statistics have succeeded regression analysis when measurement techniques are compared. However, when applied to cardiac output measurements, inconsistencies occur in reporting the results of this form of analysis...
  14. ncbi Assessment of cardiac function with the pressure-volume conductance system following myocardial infarction in mice
    Krystyna M Shioura
    The Center for Cardiovascular Research, Department of Medicine, Section of Cardiology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Heart Circ Physiol 293:H2870-7. 2007
    ....
  15. ncbi Cine-MRI versus two-dimensional echocardiography to measure in vivo left ventricular function in rat heart
    Daniel J Stuckey
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    NMR Biomed 21:765-72. 2008
    ..The accuracy of cine-MRI allows identification of alterations in heart function that may be missed when using 2D-echo...
  16. ncbi Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart
    Steven Lloyd
    Department of Medicine, University of Alabama, Birmingham, AL 35294 4470, USA
    Am J Physiol Heart Circ Physiol 285:H163-72. 2003
    ..These results may have important implications for understanding the mechanisms underlying the beneficial effects of increasing cardiac carbohydrate metabolism...
  17. pmc Synthesis, characterization and therapeutic efficacy of a biodegradable, thermoresponsive hydrogel designed for application in chronic infarcted myocardium
    Kazuro L Fujimoto
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 30:4357-68. 2009
    ..The designed poly(NIPAAm-co-AAc-co-HEMAPTMC) hydrogel of this report may thus offer an attractive biomaterial-centered treatment option for ischemic cardiomyopathy...
  18. pmc Increasing number of components of the metabolic syndrome and cardiac structural and functional abnormalities--cross-sectional study of the general population
    Ana Azevedo
    Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal
    BMC Cardiovasc Disord 7:17. 2007
    ....
  19. ncbi Exercise-induced cardioprotection--biochemical, morphological and functional evidence in whole tissue and isolated mitochondria
    Antonio Ascensao
    Department of Sports Biology, Research Center in Physical Activity, Health and Leisure, Faculty of Sport Sciences, University of Porto, Rua Dr Placido Costa, 91, 4200 450 Porto, Portugal
    Int J Cardiol 117:16-30. 2007
    ..Further work should be addressed in order to clarify the precise regulatory mechanisms by which physical exercise augments heart tolerance against many cardiotoxic agents...
  20. ncbi Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression
    M C Cho
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 274:22251-6. 1999
    ..Taken together, these data indicate that alterations in beta-adrenergic receptor signaling precede the development of overt heart failure in this mouse model of progressive cardiomyopathy...
  21. ncbi Sex differences in evaluation and outcome of unstable angina
    V L Roger
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA
    JAMA 283:646-52. 2000
    ....
  22. pmc Comparison between Flotrac-Vigileo and Bioreactance, a totally noninvasive method for cardiac output monitoring
    Sophie Marque
    Medical Intensive Care Unit, Cochin Hospital, 75679 Paris Cedex 14, France
    Crit Care 13:R73. 2009
    ....
  23. ncbi Validation of a new arterial pulse contour-based cardiac output device
    Eric E C de Waal
    Division of Perioperative and Emergency Care, University Medical Center, Utrecht, The Netherlands
    Crit Care Med 35:1904-9. 2007
    ..Vigileo cardiac output (VigileoCO) was compared with intermittent transpulmonary thermodilution cardiac output (TPCO) and an established arterial pulse contour-based cardiac output (PCCO)...
  24. ncbi Modified TEI index: a promising parameter in essential hypertension?
    Nurgul Keser
    Department of Cardiology, University of Maltepe Istanbul, Istanbul, Turkey
    Echocardiography 22:296-304. 2005
    ..We planned to determine its applicability in hypertension and relation with left ventricular mass index (LVMI)...
  25. pmc Altered serum creatine kinase level and cardiac function in ischemia-reperfusion injury during percutaneous coronary intervention
    Yi Luo
    Department of Cardiology, Guangzhou 1st People s Hospital Affiliated to Guangzhou Medical College, Guangzhou, Guangdong, China
    Med Sci Monit 17:CR474-9. 2011
    ..This study explored the relationship of cardiac function examined by echocardiography and serum creatine kinase (CK) and CK-MB levels with MIRI in a cohort of Chinese AMI patients...
  26. pmc Transpulmonary thermodilution-derived cardiac function index identifies cardiac dysfunction in acute heart failure and septic patients: an observational study
    Simon Ritter
    Intensive Care Unit, Department of Internal Medicine, Triemli City Hospital, Birmensdorferstrasse 497, CH 8063 Zurich, Switzerland
    Crit Care 13:R133. 2009
    ..Therefore, we compared the cardiac function of patients with AHF or sepsis using the pulmonary artery catheter (PAC) and the PiCCO technology...
  27. ncbi Cell transplantation for the treatment of acute myocardial infarction using vascular endothelial growth factor-expressing skeletal myoblasts
    K Suzuki
    Department of Cardiothoracic Surgery, Imperial College School of Medicine, Heart Science Centre, Harefield Hospital, Middlesex, UK
    Circulation 104:I207-12. 2001
    ....
  28. ncbi Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion
    Bo Qing Zhu
    Cardiology Section, VA Medical Center, San Francisco, California 94121, USA
    Cardiovasc Drugs Ther 18:421-31. 2004
    ..We conclude that PQQ, which appears to act as a free radical scavenger in ischemic myocardium, is a highly effective cardioprotective agent...
  29. ncbi Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction
    Yunzeng Zou
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Circulation 108:748-53. 2003
    ..Myocardial infarction (MI) is a leading cause of cardiac morbidity and mortality in many countries; however, the treatment of MI is still limited...
  30. ncbi Lack of agreement between thermodilution and fick cardiac output in critically ill patients
    Vinay K Dhingra
    Division of Critical Care Medicine, Vancouver Hospital and Health Sciences Center, University of British Columbia, Vancouver, BC, Canada
    Chest 122:990-7. 2002
    ..s: Individual comparison of cardiac output via intermittent thermodilution and Fick technique over a wide range of cardiac outputs...
  31. pmc Comparative cardiac gene delivery of adeno-associated virus serotypes 1-9 reveals that AAV6 mediates the most efficient transduction in mouse heart
    Carmela Zincarelli
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Transl Sci 3:81-9. 2010
    ..Importantly, none of the serotypes tested with this marker gene affected cardiac function nor was associated with inflammation...
  32. ncbi Dysfunction of dysferlin-deficient hearts
    Katrin Wenzel
    Department of Cardiology, Franz Volhard Clinic, Helios Clinic and Campus Virchow Clinic, Charite, Berlin, Germany
    J Mol Med (Berl) 85:1203-14. 2007
    ..Our data suggest that disturbances in dysferlin as well as Z-line proteins and transcription factors particularly under mechanical stress cause cardiomyopathy...
  33. pmc Comparison of bedside measurement of cardiac output with the thermodilution method and the Fick method in mechanically ventilated patients
    Jesus Gonzalez
    Laboratoire de Physiopathologie Respiratoire et Unité de Réanimation, Assistance Publique Hopitaux de Paris, Paris, France
    Crit Care 7:171-8. 2003
    ..Indeed, the interchangeability of the methods is a clinically relevant question; for instance, in view of the debate about the risk-benefit balance of right heart catheterization...
  34. ncbi Left ventricular systolic and diastolic functions in patients with sickle cell anemia
    Amar Taksande
    Department of Pediatrics, Mahatma Gandhi Institute of Medical Sciences, Wardha
    Indian Heart J 57:694-7. 2005
    ..Cardiovascular involvement in this condition has not been well studied. The present study therefore sought to investigate the systolic and diastolic left ventricular function of children with sickle cell anemia...
  35. ncbi Angiotensin-converting enzyme (ACE) inhibitor therapy after myocardial infarction in relation to left ventricular function
    Aasmund Reikvam
    Department of Pharmacotherapeutics, Faculty of Medicine, University of Oslo, Norway
    Scand Cardiovasc J 37:130-4. 2003
    ....
  36. ncbi Robotic-enhanced biventricular resynchronization: an alternative to endovenous cardiac resynchronization therapy in chronic heart failure
    Jean Luc Jansens
    Department of Cardiac Surgery, Erasme University Hospital, Brussels, Belgium
    Ann Thorac Surg 76:413-7; discussion 417. 2003
    ..Therefore we explored robotic-enhanced thoracoscopic implantation of an epicardial lead as an alternative technique to stimulate the LV in cardiac resynchronization therapy...
  37. ncbi Short- and long-term mechanical ventricular assistance towards myocardial recovery
    John W C Entwistle
    Department of Cardiovascular Medicine and Surgery, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    Surg Clin North Am 84:201-21. 2004
    ..Although it is unlikely that these patients will be studied in a randomized fashion, the collection of accurate and complete data may allow us to establish a database that can answer many of today's questions...
  38. ncbi Inferior vena cava diameter determines left ventricular geometry in continuous ambulatory peritoneal dialysis patients: an echocardiographic study
    Ahmet Toprak
    Department of Internal Medicine, Marmara University School of Medicine, Tophanelioglu cad No 13 15, Altunizade, 34660 Istanbul, Turkey
    Nephrol Dial Transplant 18:2128-33. 2003
    ..Geometric adaptation of LV to various stimuli was reported to have adverse prognosis. This study aimed to identify independent risk factors, which contribute to the development of LV geometric remodelling in CAPD patients...
  39. ncbi Measurement of ejection fraction after myocardial infarction in the population
    Francisco Lopez-Jimenez
    Department of Health Sciences Research, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Chest 125:397-403. 2004
    ..To assess the secular trends in left ventricular ejection fraction (LVEF) assessment after myocardial infarction (MI) and to identify the determinants of testing...
  40. ncbi Are reciprocal changes a consequence of "ischemia at a distance" or merely a benign electrical phenomenon? A pulsed-wave tissue Doppler echocardiographic study
    Sukru Celik
    Department of Cardiology, KTU Faculty of Medicine, Trabzon, Turkey
    Ann Noninvasive Electrocardiol 8:302-7. 2003
    ....
  41. ncbi Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction
    James J Pilla
    Department of Surgery, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    J Thorac Cardiovasc Surg 126:1467-76. 2003
    ..We hypothesized that placement of the cardiac support device results in a decrease in myocardial wall stress and improvement in cardiac function and myocardial energetics...
  42. ncbi Chronic kidney disease in patients with chronic heart failure--impact on intracardiac conduction, diastolic function and prognosis
    Christian Bruch
    Department of Cardiology and Angiology, Hospital of the University of Münster, Munster, Germany
    Int J Cardiol 118:375-80. 2007
    ..This study tested the impact of CKD on intracardiac conduction, diastolic function and prognosis in patients with underlying CHF...
  43. ncbi Prospective evaluation of atrial tachyarrhythmias in patients with interatrial block
    Vignendra Ariyarajah
    Massachusetts Veterans Epidemiology Research and Information Center MAVERIC, Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA
    Int J Cardiol 118:332-7. 2007
    ..We prospectively evaluated the incidence of such arrhythmias, especially atrial fibrillation among patients with interatrial block over the course of 1 year...
  44. ncbi Noninvasive assessment of cardiac mechanics and clinical outcome after partial left ventriculectomy
    Randolph M Setser
    Department of Radiology, The Cleveland Clinic Foundation, OH, USA
    Ann Thorac Surg 76:1576-85; discussion 1585-6. 2003
    ..Little is known about its effects on myocardial mechanics and their relation to clinical outcome...
  45. ncbi A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction
    Matthias Manz
    Department of Cardiology, Marienhof Hospital, Koblenz, Germany
    Cardiology 100:149-55. 2003
    ..Thus, a single intravenous dose of ivabradine produced a substantial reduction in resting heart rate without affecting LV function in patients with regional or global LV dysfunction...
  46. ncbi Prediction of heart failure post myocardial infarction: comparison of ejection fraction, transmitral filling parameters, and the index of myocardial performance
    Steven J Lavine
    Department of Medicine, Cardiovascular Center, Shands Hospital Jacksonville, University of Florida, Jacksonville, Florida 32209, USA
    Echocardiography 20:691-701. 2003
    ....
  47. ncbi Eight-year results after aortic valve replacement with the Freestyle stentless bioprosthesis
    David S Bach
    Department of Medicine, Division of Cardiology, University of Michigan, Ann Arbor, 48109, USA
    J Thorac Cardiovasc Surg 127:1657-63. 2004
    ..We sought to describe the hemodynamic and clinical outcomes for the Freestyle aortic root bioprosthesis (Medtronic, Inc, Minneapolis, Minn) in a large multicenter cohort prospectively followed for 8 years...
  48. ncbi Effects of carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure
    Pablo F Castro
    Faculty of Medicine, P Catholic University of Chile, University of Chile, Santiago, Chile
    Am J Cardiol 96:267-9. 2005
    ....
  49. ncbi Prognosis in diastolic heart failure
    Kristen M Franklin
    Division of Cardiology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Prog Cardiovasc Dis 47:333-9. 2005
    ..This article reviews the current state of knowledge regarding the prognosis of patient populations with diastolic dysfunction and diastolic heart failure...
  50. ncbi Effects of nitrates and hydralazine in heart failure: clinical evidence before the african american heart failure trial
    Uri Elkayam
    Heart Failure Program, Division of Cardiovascular Disease, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Am J Cardiol 96:37i-43i. 2005
    ..Concomitant use of HYD with a nitrate, both in an animal model and in patients with CHF, has been shown to prevent the development of nitrate tolerance and maintain the favorable hemodynamic effect of nitrates...
  51. ncbi Role of echocardiography in assessing the mechanism and effect of ramipril on functional mitral regurgitation in dilated cardiomyopathy
    I B Vijayalakshmi
    Sri Jayadeva Institute of Cardiology, Bangalore, Karnataka, India
    Echocardiography 22:289-95. 2005
    ..The lateral migration of papillary muscles possibly plays a major role in functional mitral regurgitation. Ramipril significantly reduces not only sphericity but also functional mitral regurgitation...
  52. ncbi Tei index as a method of evaluating left ventricular diastolic dysfunction in acute myocardial infarction
    Nearchos S Nearchou
    1st Cardiology Department, Hellenic Red Cross Hospital Korgialeneio Benakeio, Athens, Greece
    Hellenic J Cardiol 46:35-42. 2005
    ..The aim of this study was to examine the corresponding behaviour in relation to LV diastolic dysfunction in patients with acute myocardial infarction (AMI), a relationship that has not been studied previously...
  53. ncbi Different clinical features, biochemical profiles, echocardiographic and elctrocardiographic findings in older and younger patients with idiopathic dilated cardiomyopathy
    Hangyuan Guo
    Department of Cardiology, Huayu Hospital, China Medical University, Shaoxing, Zhejiang 312030, China
    Acta Cardiol 60:27-31. 2005
    ..To study the clinical features, biochemical profiles, echocardiographic and electrocardiographic findings in the elderly and younger with idiopathic dilated cardiomyopathy (IDCM)...
  54. ncbi Pharmacological left ventricular reverse remodeling in elderly patients receiving optimal therapy for chronic heart failure
    Giovanni Cioffi
    Department of Cardiology, Villa Bianca Hospital, Trento, Italy
    Eur J Heart Fail 7:1040-8. 2005
    ..We performed this prospective study to evaluate whether optimized therapy for heart failure also induces LV reverse remodeling in older patients...
  55. ncbi Long-term results of surgical lead implantation for biventricular pacemakers in cardiomyopathy patients
    Robert Jones
    Cornell University, Ithaca, New York, USA
    Heart Surg Forum 10:E143-6. 2007
    ..The data show that the surgical approach for cardiac resynchronization therapy has durable long-term results...
  56. ncbi Regional and global right ventricular dysfunction in asymptomatic or minimally symptomatic patients with congenitally corrected transposition
    Igor I Tulevski
    Department of Cardiology, Academic Medical Center, Amsterdam
    Cardiol Young 14:168-73. 2004
    ..Our findings support the hypothesis that, in patients with congenitally corrected transposition, ischemia of the right ventricular myocardium contributes to the development of right ventricular dysfunction...
  57. ncbi Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies
    Christof Stamm
    Department of Cardiac Surgery, University of Rostock, Rostock, Germany
    J Thorac Cardiovasc Surg 133:717-25. 2007
    ..We then tested the hypothesis that CABG plus CD133+ cell injection would result in better contractile function than CABG alone...
  58. ncbi Effects of carvedilol on ventriculo-arterial coupling in patients with heart failure
    Renato Razzolini
    Department of Cardiology, University of Padua, Padua, Italy it
    Ital Heart J 5:517-22. 2004
    ..We studied the effect of carvedilol on the Ea/Ees ratio in patients with CHF treated with ACE-inhibitors, diuretics, and digoxin...
  59. ncbi Effects of altered volume loading on left ventricular hemodynamics and diastolic filling during hemodialysis
    Kuo Chun Hung
    Second Section of Cardiology, Department of Medicine, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan
    Ren Fail 26:141-7. 2004
    ..However, previous studies offered conflicting findings. This study thus evaluated the impact of HD on LV diastolic filling indices and hemodynamics...
  60. ncbi Reversible myocardial dysfunction after cardiopulmonary resuscitation
    Manuel Ruiz-Bailén
    Intensive Care Unit, Critical Care and Emergency Department, Hospital Universitario Médico Quirúrgico, Complejo Hospitalario de Jaen, Spain
    Resuscitation 66:175-81. 2005
    ..The aim of the present work has been to study and describe the possible development of myocardial dysfunction in patients resuscitated after cardio-respiratory arrest, in the absence of acute or previous coronary artery disease...
  61. ncbi Hemodynamic and plasma atrial natriuretic peptide responses to acute digitalis therapy in patients with normal and impaired left ventricular function
    Wayne L Miller
    Division of Cardiovascular Diseases, Department of Biostatistics, Mayo Clinic and Mayo Foundation, 200 First Street, SW, Rochester, MN 55905, USA
    Eur J Heart Fail 4:63-72. 2002
    ..Digitalis has a long history in the treatment of heart failure but its effects on cardiac hemodynamics and neurohormonal modulation are not well characterized...
  62. ncbi Acute effects of cardiac resynchronization therapy on functional mitral regurgitation in advanced systolic heart failure
    Ole A Breithardt
    Department of Cardiology, University Hospital, Aachen, Germany
    J Am Coll Cardiol 41:765-70. 2003
    ..We studied the acute effects of cardiac resynchronization therapy (CRT) on functional mitral regurgitation in heart failure (HF) patients with left bundle branch block (LBBB)...
  63. ncbi Angiographic findings, time course of regional and global left ventricular function, and clinical outcome in diabetic patients with acute myocardial infarction treated with primary percutaneous transluminal coronary angioplasty
    Leonardo Bolognese
    Division of Cardiology, S Donato Hospital, Arezzo, Italy
    Am J Cardiol 91:544-9. 2003
    ..51, 95% CI 1.04 to 2.18, p = 0.03). Thus, diabetes is an independent predictor of clinical outcome even if PTCA is used as the primary reperfusion strategy...
  64. ncbi Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure
    Benjamin H Trichon
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    Am J Cardiol 91:538-43. 2003
    ..MR is common in patients with LV systolic dysfunction and heart failure. After adjusting for other clinical variables, the presence of MR independently predicted worsened survival...
  65. ncbi Pseudonormalized Doppler total ejection isovolume (Tei) index in patients with right ventricular acute myocardial infarction
    Shiro Yoshifuku
    First Department of Internal Medicine, Kagoshima University School of Medicine, Kagoshima City, Japan
    Am J Cardiol 91:527-31. 2003
    ..01). The RV Tei index is generally increased in patients with RV infarction; however, severe RV infarction can be manifested with limited or no increase in the Tei index (pseudonormalization)...
  66. ncbi Exercise training without ventricular remodeling in patients with moderate to severe left ventricular dysfunction early after acute myocardial infarction
    Yoritaka Otsuka
    Department of Medicine, Division of Cardiology, National Cardiovascular Center, Fujishirodai 5 7 1, Suita, 565 8565, Osaka, Japan
    Int J Cardiol 87:237-44. 2003
    ....
  67. ncbi Assessment of left ventricular systolic and diastolic functions in children with merosin-positive congenital muscular dystrophy
    Naci Ceviz
    Cardiology Unit, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, Turkey
    Int J Cardiol 87:129-33; discussion 133-4. 2003
    ..Our results suggest that left ventricular systolic abnormalities may occur in children with merosin-positive congenital muscular dystrophy...
  68. ncbi Myocardial perfusion and coronary flow reserve assessed by positron emission tomography in patients after Fontan-like operations
    M Hauser
    Deutsches Herzzentrum Munchen, Pediatric Cardiology, Lazarettstrasse 36, 80636 Munich, Germany
    Pediatr Cardiol 24:386-92. 2003
    ..05). Altered MBF, increased meridional wall stress, and impaired CFR are common findings in FLO. Attenuated CFR and reduced ventricular function are significantly correlated and may be risk factors for the long-term outcome...
  69. ncbi Effect of nebivolol on left ventricular function in patients with chronic heart failure: a pilot study
    Bernhard R Brehm
    Medizinische Klinik III, Otfried Müllerstr 10, 72076 Tubingen, Germany
    Eur J Heart Fail 4:757-63. 2002
    ..Sympathetic activity is a significant predictor of a poor prognosis in heart failure. Beta-blockers have been shown to improve the prognosis of patients with heart failure...
  70. ncbi Acute haemodynamic effects of oestrogen administration in male patients with chronic heart failure
    Stamatis Adamopoulos
    Second Department of Cardiology, Onassis Cardiac Surgery Centre, 356 Syngrou Avenue, 176 74 Athens, Greece
    Eur J Heart Fail 4:719-26. 2002
    ..Although there are many studies concerning the effects of long-term oestrogen administration on systemic haemodynamics in postmenopausal women, the effects of oestrogen in patients with chronic heart failure are not defined...
  71. ncbi MADIT-II: clinical implications
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Card Electrophysiol Rev 6:463-5. 2002
    ..These preliminary findings raise questions about the clinical usefulness of electrophysiologic testing as a risk stratifier in patients with advanced left ventricular dysfunction...
  72. ncbi Defibrillation threshold and cardiac responses using an external biphasic defibrillator with pediatric and adult adhesive patches in pediatric-sized piglets
    Cheryl R Killingsworth
    Cardiac Rhythm Management Laboratory, Department of Medicine, Division of Cardiovascular Diseases, University of Alabama at Birmingham, 1670 University Boulevard, B140 Volker Hall, Birmingham, AL 35294, USA
    Resuscitation 55:177-85. 2002
    ..These data suggest that there is a substantial safety margin above a DFT strength shock for this biphasic waveform in piglets...
  73. ncbi In-vivo analysis of the instantaneous transvalvular pressure difference-flow relationship in aortic valve stenosis: implications of unsteady fluid-dynamics for the clinical assessment of disease severity
    Javier Bermejo
    Department of Cardiology, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Heart Valve Dis 11:557-66. 2002
    ..This study was designed to assess the fluid-dynamics of aortic valve stenosis in order to clarify which index best accounts for disease severity. The diagnostic implications of reversed deltaP during ejection were also investigated...
  74. ncbi Echocardiographic evidence of cardiac involvement in ankylosing spondylitis
    A Yildirir
    Baskent University, Ankara, Turkey
    Clin Rheumatol 21:129-34. 2002
    ..Further studies are needed to clarify the prognostic significance of diastolic abnormalities and the value of P-wave analysis in cardiac evaluation of these patients...
  75. ncbi Serial exercise performance in children with surgically corrected congenital aortic stenosis
    B M Mitchell
    Dr Scholl Cardiac Exercise Laboratory, Division of Cardiology, Children s Memorial Hospital, Chicago, IL 60614, USA
    Pediatr Cardiol 24:319-24. 2003
    ..6 years. Children with operated and nonoperated AS were able to reach or exceed normal endurance times, which may make it difficult to achieve compliance to imposed activity restrictions in this population...
  76. ncbi Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure
    Martin G St John Sutton
    Division of Cardiology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Circulation 107:1985-90. 2003
    ..The purpose of the present study was to determine whether improvements in left ventricular (LV) size and function were associated with CRT...
  77. ncbi Mitral valve surgery for mitral regurgitation in patients with advanced dilated cardiomyopathy
    Giuseppe Gatti
    Department of Cardiac Surgery, Villa Torri Hospital, Bologna, Italy
    Ital Heart J 4:29-34. 2003
    ..Some authors believe that only heart transplantation is the really effective surgical treatment. We analyzed our clinical and echocardiographic results after mitral repair or replacement in this difficult subset of patients...
  78. ncbi Edge-to-edge repair for functional mitral regurgitation: an echocardiographic study of the hemodynamic consequences
    Tim D Kinnaird
    Cardiac Echo Laboratory, St Paul s Hospital, and the University of British Columbia, Vancouver, BC, Canada
    J Heart Valve Dis 12:280-6. 2003
    ..The possibility that preoperative dobutamine stress echocardiography (DSE) might be used to predict post-repair recovery in LV function was also examined...
  79. ncbi A critical evaluation of results of partial left ventriculectomy
    P P Lunkenheimer
    Klinik und Poliklinik fur Thorax, Herz und Gefèasschirurgie, University Munster, Germany
    J Card Surg 18:225-35. 2003
    ....
  80. ncbi Intracardiac left ventricular support in beating heart, multi-vessel revascularization
    Frank Isgro
    Clinic for Cardiac Surgery, Heart Institute Ludwigshafen, Germany
    J Card Surg 18:240-4. 2003
    ....
  81. ncbi Clinical cellular cardiomyoplasty: technical considerations
    Fumin Zhang
    The First Affiliated Hospital of Nanjing Medical University, Nanjing, P R China
    J Card Surg 18:268-73. 2003
    ..Our experience indicated the safety and early benefit of cellular cardiomyoplasty using autologous satellite cells...
  82. ncbi Echocardiographic findings in subjects with psoriatic arthropathy
    H Saricaoglu
    Uludad University Medical Faculty, Department of Dermatology, Bursa, Turkey
    J Eur Acad Dermatol Venereol 17:414-7. 2003
    ..Psoriatic arthropathy (PA) is a seronegative arthropathy with a 5-20% prevalence among psoriatics. In recent years, cardiovascular abnormalities have been shown in patients with seronegative arthropathies...
  83. ncbi Ventricular constraint in severe heart failure halts decline in cardiovascular function associated with experimental dilated cardiomyopathy
    Jai S Raman
    Department of Cardiac Surgery, Austin and Repatriation Medical Centre, Heidelberg, Melbourne, Victoria, Australia
    Ann Thorac Surg 76:141-7. 2003
    ..We report on ventricular constraint in severe heart failure...
  84. ncbi Evaluation of left ventricular enlargement in the lateral position of the chest using the Hoffman and Rigler sign
    V Freeman
    Cadiac Unit, Department of Medicine, Tygerberg Hospital and University of Stellenbosch, Stellenbosch, South Africa
    Cardiovasc J S Afr 14:134-7. 2003
    ..To evaluate left ventricular enlargement in the lateral projection of the chest using the Hoffman and Rigler sign...
  85. ncbi Adequate left ventricular preparation allows for arterial switch despite late referral
    Antonio E Corno
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Cardiol Young 13:49-52. 2003
    ..To evaluate the feasibility of the arterial switch for surgical repair of transposition, defined as the combination of concordant atrioventricular and discordant ventriculo-arterial connections, after late referral...
  86. ncbi Moderate ischemic mitral regurgitation and coronary artery bypass surgery: effect of mitral repair on clinical outcome
    Marisa Di Donato
    San Donato Hospital, San Donato Milanese, Milan, Italy
    J Heart Valve Dis 12:272-9. 2003
    ..The study aim was to determine whether mitral repair associated with CABG is preferable to CABG alone in patients with moderate ischemic MR, in terms of intermediate outcome...
  87. ncbi Effects of therapeutic beta blockade on myocardial function and cardiac remodelling in congenital cardiac disease
    Reiner Buchhorn
    Department of Pediatric Cardiology, Georg August University, Gottingen, Germany
    Cardiol Young 13:36-43. 2003
    ..Little is known about the influence of different therapies for cardiac failure on the remodelling seen in infants with congenital cardiac disease...
  88. ncbi Predictors of early outcome after coronary artery surgery in patients with severe left ventricular dysfunction
    Naresh Trehan
    Escorts Heart Institute and Research Centre, Okhla Road, New Delhi 110025, India
    J Card Surg 18:101-6. 2003
    ..The surgical survival in patients with severe myocardial dysfunction is critically dependent on the selection of patients. The present study was undertaken to identify the prognostic factors in such patients...
  89. ncbi Surgical treatment of post infarction left ventricular aneurysms: our experience with double breasting and Dor's repair
    Naresh Trehan
    Escorts Heart Institute and Research Centre, New Delhi, India
    J Card Surg 18:114-20. 2003
    ..Two methods of LV aneurysm repair are practiced: double breasting (DB) and Dor's repair. The method varies with location, size, and extent of aneurysm and quality of the fibrotic wall of the aneurysm...
  90. ncbi Long-term events in adult patients with clinical stage IA-IIA nonbulky Hodgkin's lymphoma treated with four cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine and adjuvant radiotherapy: a single-institution 15-year follow-up
    Ercole Brusamolino
    Clinica Ematologica and Servizio di Radioterapia Oncologica, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, University of Pavia, Pavia, Italy
    Clin Cancer Res 12:6487-93. 2006
    ..To report on long-term events after short doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy and adjuvant radiotherapy in favorable early-stage Hodgkin's lymphoma...
  91. ncbi [Role of surgical lung volume reduction in the treatment of patients with severe emphysema]
    László Kecskés
    Vas Megye es Szombathely MJV Markusovszky Kórháza Egyetemi Oktatókórház Mellkassebészeti Osztály
    Magy Seb 57:370-7. 2004
    ....
  92. ncbi Haemodynamics and gas exchange in liver cirrhosis: the effect of orally administered almitrine bismesylate
    G Nakos
    Sismanoglio General Hospital, ICU Athens, Greece
    Respir Med 87:93-8. 1993
    ..The data suggest a weak HPV response in this group of cirrhotics; that response may be enhanced by almitrine...
  93. ncbi On-site preparation of technetium-99m labeled human serum albumin for clinical application
    Yuh Feng Wang
    Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
    Tohoku J Exp Med 211:379-85. 2007
    ..These data indicate that our preparation of Tc-99m HSA is useful and potentially applicable clinically. In addition, this on-site preparation provides the possibility of labeling a patient's own serum for subsequent clinical application...
  94. ncbi Mucoepidermoid carcinoma of the thymus: a case presentation and a literature review
    D Stefanou
    Department of Pathology, Medical School, University of Ioannina, 45110 Ioannina, Greece
    Pathol Res Pract 200:567-73. 2004
    ..We report on a case of a 53-year-old man, who presented chest discomfort, dyspnea, and weakness. As heart function tests were normal, the patient underwent radiologic examination, which showed a well-demarcated mass in the ..
  95. ncbi Responsiveness of the Chinese Quality of Life Instrument in patients with congestive heart failure
    Li Zhao
    School of Chinese Medicine, The Chinese University of Hong Kong, Department of Occupational Therapy, Queen Elizabeth Hospital, Hong Kong, China
    Chin J Integr Med 14:173-9. 2008
    ....
  96. ncbi Evaluation of type 1 diabetics for simultaneous pancreas-kidney transplantation with regard to cardiovascular risk
    G Woeste
    Department of General and Vascular Surgery, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    Transplant Proc 38:747-50. 2006
    ..In case of a suspicious finding or a history of CAD, a coronary angiogram should be performed to assess the need for revascularization. Following this algorithm we may further reduce the mortality of SPK...
  97. ncbi Hypertrophic cardiomyopathy caused by hyperparathyroidism. Report of a case and review of the literature
    S Janssens
    Cardiology Division, Academic Hospital, Katholieke Universiteit Leuven, Belgium
    Acta Cardiol 42:287-93. 1987
    ..Cardiac function tests remained unchanged fifteen years after parathyroidectomy, suggesting that the latter intervention did not reverse the pathological process but only prevented further cardiac deterioration...
  98. pmc Efficacy and safety of a high protein, low carbohydrate diet for weight loss in severely obese adolescents
    Nancy F Krebs
    Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Aurora, CO 80045, USA
    J Pediatr 157:252-8. 2010
    ..To evaluate the efficacy and safety of a carbohydrate restricted versus a low fat diet on weight loss, metabolic markers, body composition, and cardiac function tests in severely obese adolescents...
  99. doi Stunning, hibernation, and assessment of myocardial viability
    Paolo G Camici
    Medical Research Council Clinical Sciences Centre and National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 117:103-14. 2008
  100. ncbi Frequency and management of troponin I elevation in patients treated with molecular targeted therapies in phase I trials
    Stephane Ederhy
    Department of Cardiology, Saint Antoine University and Medical School, Paris, France
    Invest New Drugs 30:611-5. 2012
    ..The frequency of cardiac events among patients receiving MTT has been evaluated in various ways, particularly troponin elevations...
  101. ncbi Non-invasive measurements of cardiac output in atrial fibrillation: inert gas rebreathing and impedance cardiography
    Philip S Osbak
    Department of Cardiology, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Scand J Clin Lab Invest 71:304-13. 2011
    ..Objective. To assess the validity of these methods in AF, a new inert gas rebreathing device and impedance cardiography was tested with echocardiography as reference...

Research Grants64

  1. Oxidative Stress in Sleep Apnea and Cardiac Disease
    Reena Mehra; Fiscal Year: 2010
    ..The proposal will provide a key training opportunity to foster my development as an independent clinical epidemiologist with commitment to patient-based research in sleep medicine and cardiopulmonary disease. ..
  2. LONG QT SYNDROME--GENETIC STUDIES
    Arthur Moss; Fiscal Year: 2002
    ....
  3. THERAPUTIC TRIAL IN PATIENTS WITH LQTS 3 GENE MUTATION
    Arthur Moss; Fiscal Year: 2002
    ..The significance of this work relates to the future use of molecular therapeutics to treat ion-channel disorders associated with congenital and acquired cardiac repolarization disorders. ..
  4. Obesity and Surgical Outcomes
    Jeffrey H Silber; Fiscal Year: 2010
    ..The multi-institutional OBSOS study will examine differences in outcomes and treatments between obese and normal weight patients, and in so doing, should make important contributions to the care of these patients. ..
  5. ACTION - A CHF Trial Investigating Outcomes of Exercise
    Steven Keteyian; Fiscal Year: 2007
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  6. THROMBOGENIC FACTORS AND RECURRENT CORONARY EVENTS
    Arthur Moss; Fiscal Year: 2003
    ..abstract_text> ..
  7. HIGH RESOLUTION ECHOCARDIOGRAPHY SYSTEM
    Michael Zile; Fiscal Year: 2001
    ..This will foster interdisciplinary investigation, support NIH-funded investigators and trainees, and enhance the competitiveness of MUSC investigators. ..
  8. CONDITIONAL LENGTH OF STAY: A PEDIATRICS OUTCOME MEASURE
    JEFFREY SILBER; Fiscal Year: 2001
    ..Finally, (5) policy recommendations and guidelines for the use of CLOS to measure pediatric quality of care will be developed. ..
  9. Adenosine Receptor-Mediated Protection in Reperfused MI
    George Beller; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  10. Patient Oriented Research in Pediatric Nutrition
    Nancy Krebs; Fiscal Year: 2008
    ..abstract_text> ..
  11. Invasive Assessment of the Coronary Microcirculation
    William Fearon; Fiscal Year: 2008
    ..abstract_text> ..
  12. Maintainance of Organ Function Following Injury
    Irshad Chaudry; Fiscal Year: 2008
    ..abstract_text> ..
  13. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2008
    ..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. [unreadable] [unreadable]..
  14. Behavioral Treatment of High Blood Pressure
    James Blumenthal; Fiscal Year: 2008
    ..abstract_text> ..
  15. MRI Detection of Doxorubicin Induced Cardiotoxicity
    WILLIAM HUNDLEY; Fiscal Year: 2007
    ..In addition, further animal studies will be designed to identify treatment strategies for Doxorubicin induced cardiotoxicity. [unreadable] [unreadable]..
  16. APOE Genotype and Sequelae of Infant Cardiac Surgery
    James Gaynor; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  17. VisualSonics Vevo 770 Imaging System
    Lawrence Young; Fiscal Year: 2007
    ..Adult cardiovascular disease is the leading cause of death in this country and congenital heart disease a major cause of disability and death in children. [unreadable] [unreadable] [unreadable]..
  18. Multifactor Risk Reduction for Optimal Management in Peripheral Arterial Disease
    Roberta K Oka; Fiscal Year: 2010
    ..This study will examine the effect of a system that assists providers to reduce a patient's CVD risk factors and explores the biological reasons that this system may be effective in improving health. ..
  19. Long Term Cardiovascular Effects of Inhaled Nanoparticles
    Lung Chi Chen; Fiscal Year: 2008
    ..Ultimately, a systems approach will be developed to the understanding of nanomaterials toxicology sufficiently complete to allow predictions about health effects. [unreadable] [unreadable] [unreadable] [unreadable]..
  20. Chronic Kidney Disease and Cardiovascular Risk in Black and White Young Adults
    Kirsten Bibbins Domingo; Fiscal Year: 2010
    ..These findings will be important as a guide for preventive efforts and future research, particularly in Blacks. ..
  21. The Effect of Statins on Skeletal Muscle Function
    PAUL DAVIS THOMPSON; Fiscal Year: 2010
    ....
  22. Effect Of Weight-Increased Psychotropic Medications on Appetite Regulation
    KIMBERLY ANN BROWNLEY; Fiscal Year: 2010
    ..Ultimately, information gained from this study may be instrumental in reducing obesity and obesity-related morbidities in patients with severe mental illness. ..
  23. Exercise, Depression, and Cardiac Risk
    James A Blumenthal; Fiscal Year: 2010
    ..The data generated from this study will have important clinical significance by determining the extent to which exercise may reduce depression and improve intermediate markers of CHD risk in vulnerable cardiac patients. ..
  24. MYOCARDIAL PRESERVATION DURING ISCHEMIC ARREST
    DIPAK DAS; Fiscal Year: 2009
    ..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
  25. PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURY
    DIPAK DAS; Fiscal Year: 2009
    ....
  26. Inhomogeneous Sympathetic Innervation in IHD
    JAMES FALLAVOLLITA; Fiscal Year: 2008
    ..Therefore, these studies will translate basic observations in animals to clinical pathophysiology in humans and identify novel substrate factors that contribute to the risk of SD in chronic ischemic heart disease. ..
  27. Mechanisms of Cardiac Regeneration
    DINENDER SINGLA; Fiscal Year: 2008
    ..The results from the proposed projects will have long-term implications for future cell-based therapy to treat heart disease (s) using embryonic stem cells or potentially other donor cells. [unreadable] [unreadable] [unreadable]..
  28. Comprehensive MR Imaging of Elderly Vascular Function
    WILLIAM HUNDLEY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Novel hybrid AAV vectors for cystic fibrosis gene therapy
    Dongsheng Duan; Fiscal Year: 2008
    ..This is a generic approach independent of the transgene sequence. [unreadable] [unreadable] [unreadable]..
  30. Building a New Model for Diagnosis of ED Dizzy Patients
    David Newman Toker; Fiscal Year: 2007
    ..This research project and the research paradigms derived from it will form the nucleus of a career devoted to research in medical decision-making, causes of diagnostic errors, and methods to preventthem. ..
  31. STICH Trial Radionuclide Core Laboratory
    Robert Bonow; Fiscal Year: 2007
    ..abstract_text> ..
  32. NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
    Michael Givertz; Fiscal Year: 2003
    ..abstract_text> ..
  33. IMPROVING HEALTH OUTCOMES IN UNPARTNERED CARDIAC ELDERS
    Sally Rankin; Fiscal Year: 2003
    ..Social support and self-efficacy are mediating variable sand will be measured by the MOS Social Support Scale and the Jenkins Self-Efficacy Expectation scales for Walking and General Activity. ..
  34. EXERCISE TRAINING AND DEPRESSION IN OLDER ADULTS
    James Blumenthal; Fiscal Year: 2004
    ..The study also will provide information regarding the relationship between vascular depression and various indices of vascular and neurocognitive function, and the extent to which these indices may be modifiable by treatment. ..
  35. Hypothermia for Acute Brain Injury in Children
    Charles Cox; Fiscal Year: 2004
    ..abstract_text> ..
  36. Effect of Age on Exercise-Induced Cardioprotection
    JOSEPH STARNES; Fiscal Year: 2003
    ..The results of this Aim will provide key direction for the effective design of further comprehensive studies using inhibitors and/or activators of specific proteins or signaling pathways. ..
  37. Functional decline following surgery in older adults
    VICTOR LEGNER; Fiscal Year: 2004
    ..Identified modifiable factors will direct future interventions in older adults at highest risk for functional decline following surgery. ..
  38. MICROVASCULAR INJURY DURING EXTRACORPOREAL LIFE SUPPORT
    Charles Cox; Fiscal Year: 2004
    ..Dr. McIntire's expertise in PMN/endothelial/blood flow interactions will provide an important addition to the candidate's training. ..
  39. VENTRICULAR FUNCTION DURING CARDIAC SURGERY
    HENRY SPOTNITZ; Fiscal Year: 2005
    ....
  40. Acuson Sequoia Ultrasonograph
    Brian Hoit; Fiscal Year: 2003
    ....
  41. ANTIDEPRESSANT TREATMENT OF MELANCHOLIA IN LATE LIFE
    Steven Roose; Fiscal Year: 2001
    ..Finally, The applicants expect HRQOL to show continued improvement during the continuation phase in euthymic patients and an advantage for the SSRI in HRQOL improvement due to a superior side effect profile. ..
  42. Cyclooxygenase Pathway and Diabetic Neuropathy
    Rodica Pop Busui; Fiscal Year: 2005
    ..abstract_text> ..
  43. Expert Visual Guidance of Ultrasound for Telemedicine
    Florence Sheehan; Fiscal Year: 2006
    ..Specific Aim #4 is to make the guidance easily applicable to different organs. [unreadable] [unreadable]..
  44. Myocardial Infarction in the Population
    Veronique Roger; Fiscal Year: 2006
    ..To optimize the training potential of these series of studies and the learning experience of mentees a strong mentoring plan is outlined in details in this revised application. ..
  45. Modified Late Infarct Reperfusion to Prevent Post MI CHF
    Robert Gorman; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  46. STRESS AND MYOCARDIAL ISCHEMIA--MECHANISMS AND TREATMENT
    James Blumenthal; Fiscal Year: 2002
    ....
  47. Role of IGF-1 In Diastolic Dysfunction of Aging
    Leanne Groban; Fiscal Year: 2003
    ..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
  48. Lineage Specific Stem Cell Mobilization for Heart Repair
    Yigang Wang; Fiscal Year: 2009
    ..The results of cytokine-mediated regeneration therapy may become a novel therapeutic strategy for MI. . ..
  49. NURSING INTERVENTIONS FOLLOWING SUDDEN CARDIAC ARREST
    CYNTHIA DOUGHERTY; Fiscal Year: 2001
    ..The findings are expected to be generalizable to other populations of high risk patients who leave the hospital after a very short stay, and to whom close follow-up cre by advanced practice nurses would be advantageous. ..
  50. IGF-1, Oxidative Stress and Cardiovascular Aging
    Jun Ren; Fiscal Year: 2002
    ..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
  51. Cardiac KATP Channels in Health and Disease
    Andre Terzic; Fiscal Year: 2007
    ..Thus, this proposal will provide an integrated understanding of cardiac KATP channels in metabolic signal decoding, stress adaptation, and their impact for clinical medicine. ..
  52. Modulation of Cardiac Mechanics in AL Amyloidosis
    Theodore Abraham; Fiscal Year: 2005
    ..The long-term goal of this research is to better understand the factors that influence the development of cardiac dysfunction in AL with the aim of optimizing treatment strategies to improve clinical outcomes in AL patients. ..
  53. Androgens and Myocardial Relaxation in the Aging Heart
    Theodore Abraham; Fiscal Year: 2008
    ..Most importantly, potential direct clinical benefits of this research include early detection, improved and novel therapy, and better clinical outcomes for age-related diastolic dysfunction. ..
  54. Calpain and Calpastatin Regulation of Reperfusion Injury
    JODIE DUFFY; Fiscal Year: 2008
    ..Determining calpain and calpastatin regulation of these pathways identifies therapeutic targets to reduce postoperative myocardial dysfunction in pediatric patients. ..
  55. PARADIGM SHIFTS IN CLINICAL ISCHEMIA DETECTION
    Philip Binkley; Fiscal Year: 2004
    ..abstract_text> ..
  56. Changes in Functional Status Across Therapy for Primary Glioma
    Lee Jones; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
    ..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
  58. Bionic Baroreflex System for Blood Pressure Control
    Andre Diedrich; Fiscal Year: 2002
    ..A Phase II study would involve studies in animals and in patients with MSA to determine the long-term efficacy of the bionic baroreflex system in improving blood pressure control...
  59. HEPATITIS C IN CHILDHOOD CANCER SURVIVORS
    Melissa Hudson; Fiscal Year: 2003
    ..abstract_text> ..
  60. PARADIGM SHIFTS IN CLINICAL ISCHEMIA DETECTION
    Philip Binkley; Fiscal Year: 2002
    ..abstract_text> ..