positron emission tomography

Summary

Summary: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and BRAIN. SPECT is closely related to PET, but uses isotopes with longer half-lives and resolution is lower.

Top Publications

  1. ncbi Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
  2. ncbi Partial-volume effect in PET tumor imaging
    Marine Soret
    UMR 678 INSERM UPMC, CHU Pitie Salpetriere, Paris, France
    J Nucl Med 48:932-45. 2007
  3. pmc Identification and importance of brown adipose tissue in adult humans
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 360:1509-17. 2009
  4. ncbi Cold-activated brown adipose tissue in healthy men
    Wouter D van Marken Lichtenbelt
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, The Netherlands
    N Engl J Med 360:1500-8. 2009
  5. ncbi Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    Henry Engler
    Uppsala Imanet AB, Imanet, GE Healthcare Uppsala University, Uppsala
    Brain 129:2856-66. 2006
  6. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
  7. ncbi Positron-emission tomography and assessment of cancer therapy
    Malik E Juweid
    Department of Radiology and the Holden Comprehensive Cancer Center, University of Iowa, Iowa City 52242, USA
    N Engl J Med 354:496-507. 2006
  8. ncbi Basal ganglia functional connectivity based on a meta-analysis of 126 positron emission tomography and functional magnetic resonance imaging publications
    Ronald B Postuma
    Montreal Neurological Institute, Montreal General Hospital, McGill University, 3801 University Street Montreal, Quebec H3A 2B4, Canada
    Cereb Cortex 16:1508-21. 2006
  9. ncbi Recommendations on the use of 18F-FDG PET in oncology
    James W Fletcher
    Department of Radiology, Indiana Purdue University, Indiana University School of Medicine, Indianapolis, Indiana 46202 5253, USA
    J Nucl Med 49:480-508. 2008
  10. pmc The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core
    William J Jagust
    Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA
    Alzheimers Dement 6:221-9. 2010

Detail Information

Publications363 found, 100 shown here

  1. ncbi Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
  2. ncbi Partial-volume effect in PET tumor imaging
    Marine Soret
    UMR 678 INSERM UPMC, CHU Pitie Salpetriere, Paris, France
    J Nucl Med 48:932-45. 2007
    ..The parameters on which PVE depends are reviewed. Actions that can be taken to reduce the errors attributable to PVE are described. Various PVE correction schemes are presented, and their applicability to PET tumor imaging is discussed...
  3. pmc Identification and importance of brown adipose tissue in adult humans
    Aaron M Cypess
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 360:1509-17. 2009
    ....
  4. ncbi Cold-activated brown adipose tissue in healthy men
    Wouter D van Marken Lichtenbelt
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, The Netherlands
    N Engl J Med 360:1500-8. 2009
    ..Brown-adipose-tissue activity was studied in relation to body composition and energy metabolism...
  5. ncbi Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    Henry Engler
    Uppsala Imanet AB, Imanet, GE Healthcare Uppsala University, Uppsala
    Brain 129:2856-66. 2006
    ..FDG imaging may be able to detect a stabilization of cerebral metabolism caused by therapy administered to patients with a clinical diagnosis of Alzheimer's disease...
  6. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ..deposition in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging, and its relationship to cognitive function, measured with a battery of ..
  7. ncbi Positron-emission tomography and assessment of cancer therapy
    Malik E Juweid
    Department of Radiology and the Holden Comprehensive Cancer Center, University of Iowa, Iowa City 52242, USA
    N Engl J Med 354:496-507. 2006
  8. ncbi Basal ganglia functional connectivity based on a meta-analysis of 126 positron emission tomography and functional magnetic resonance imaging publications
    Ronald B Postuma
    Montreal Neurological Institute, Montreal General Hospital, McGill University, 3801 University Street Montreal, Quebec H3A 2B4, Canada
    Cereb Cortex 16:1508-21. 2006
    ..The rostrocaudal and dorsoventral patterns of corticostriatal functional connectivity are consistent with the tripartite division of the striatum into motor, associative, and limbic zones...
  9. ncbi Recommendations on the use of 18F-FDG PET in oncology
    James W Fletcher
    Department of Radiology, Indiana Purdue University, Indiana University School of Medicine, Indianapolis, Indiana 46202 5253, USA
    J Nucl Med 49:480-508. 2008
    ..Outcomes of interest included the use of (18)F-FDG PET for diagnosing, staging, and detecting the recurrence or progression of cancer...
  10. pmc The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core
    William J Jagust
    Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA
    Alzheimers Dement 6:221-9. 2010
    This is a progress report of the Alzheimer's Disease Neuroimaging Initiative (ADNI) positron emission tomography (PET) Core.
  11. ncbi Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma
    Malik E Juweid
    Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
    J Clin Oncol 25:571-8. 2007
    To develop guidelines for performing and interpreting positron emission tomography (PET) imaging for treatment assessment in patients with lymphoma both in clinical practice and in clinical trials.
  12. ncbi Impact of animal handling on the results of 18F-FDG PET studies in mice
    Barbara J Fueger
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 47:999-1006. 2006
    ..The aim of this study was to determine how these factors affect assessment of tumor glucose use by (18)F-FDG PET and to develop an imaging protocol that optimizes visualization of tumor xenografts...
  13. pmc Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD
    Roland Haubner
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Germany
    PLoS Med 2:e70. 2005
    ..We developed [(18)F]Galacto-RGD, a (18)F-labeled glycosylated alphavbeta3 antagonist, allowing monitoring of alphavbeta3 expression with positron emission tomography (PET).
  14. ncbi Revised response criteria for malignant lymphoma
    Bruce D Cheson
    Division of Hematology Oncology, Georgetown University Hospital, Washington, DC, USA
    J Clin Oncol 25:579-86. 2007
    ..Standardized response criteria are needed to interpret and compare clinical trials and for approval of new therapeutic agents by regulatory agencies...
  15. ncbi Primary tumor standardized uptake value (SUVmax) measured on fluorodeoxyglucose positron emission tomography (FDG-PET) is of prognostic value for survival in non-small cell lung cancer (NSCLC): a systematic review and meta-analysis (MA) by the European Lu
    Thierry Berghmans
    Department of Intensive Care Unit and Thoracic Oncology, Institut Jules Bordet, Universite Libre de Bruxelles ULB, Bruxelles, Belgium
    J Thorac Oncol 3:6-12. 2008
    The 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography is an imaging tool for assessing clinical tumor, node, metastasis in non-small cell lung cancer (NSCLC)...
  16. ncbi Conditioned dopamine release in humans: a positron emission tomography [11C]raclopride study with amphetamine
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:3998-4003. 2007
    ..In the present study, we used positron emission tomography and [11C]raclopride to investigate whether amphetamine-predictive stimuli can elicit striatal dopamine ..
  17. pmc Electrical impedance tomography compared to positron emission tomography for the measurement of regional lung ventilation: an experimental study
    J C Richard
    Service de Réanimation Médicale et d Assistance Respiratoire, Hôpital de la Croix Rousse 103 Grande Rue de la Croix Rousse, Lyon, 69004, France
    Crit Care 13:R82. 2009
    ..This experiment systematically compared both techniques in injured and non-injured lungs...
  18. ncbi Glioma proliferation as assessed by 3'-fluoro-3'-deoxy-L-thymidine positron emission tomography in patients with newly diagnosed high-grade glioma
    Roland Ullrich
    Max Planck Institute for Neurological Research with Klaus Joachim Zülch Laboratories, Cologne, Germany
    Clin Cancer Res 14:2049-55. 2008
    ....
  19. ncbi Primary tumor standardized uptake value measured on fluorodeoxyglucose positron emission tomography is of prognostic value for survival in non-small cell lung cancer: update of a systematic review and meta-analysis by the European Lung Cancer Working Part
    Marianne Paesmans
    Data Centre, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    J Thorac Oncol 5:612-9. 2010
    ..F]-fluoro-2-deoxy-d-glucose positron emission tomography has been shown to be of additional value to conventional imaging for staging lung cancer...
  20. ncbi Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD
    Lisa Mosconi
    Department of Clinical Pathophysiology, University of Florence, Italy
    Eur J Nucl Med Mol Imaging 32:486-510. 2005
    ..Fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) imaging has revealed glucose metabolic reductions in the parieto-temporal, frontal and ..
  21. ncbi Vascular inflammation in patients with impaired glucose tolerance and type 2 diabetes: analysis with 18F-fluorodeoxyglucose positron emission tomography
    Tae Nyun Kim
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
    Circ Cardiovasc Imaging 3:142-8. 2010
    ..18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for indentifying and quantifying vascular inflammation within atherosclerotic ..
  22. ncbi Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport
    Stina Syvänen
    Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Drug Metab Dispos 37:635-43. 2009
    ..to compare brain uptake of three radiolabeled P-glycoprotein (P-gp) substrates across species using positron emission tomography. Brain concentrations and brain-to-plasma ratios were compared; [(11)C]verapamil in rats, guinea pigs, ..
  23. ncbi Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease
    S Kajander
    Turku PET Centre, Turku, Finland
    Circulation 122:603-13. 2010
    ..Perfusion imaging has an established role in detecting ischemia and guiding therapy. Hybrid positron emission tomography (PET)/CT allows combination angiography and perfusion imaging in short, quantitative, low-radiation-..
  24. ncbi Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  25. ncbi Brain glucose metabolism in hypothyroidism: a positron emission tomography study before and after thyroid hormone replacement therapy
    M Bauer
    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus Dresden, Technische Universitat Dresden, Fetscherstrasse 74, Dresden, Germany
    J Clin Endocrinol Metab 94:2922-9. 2009
    ..Hypothyroidism is frequently associated with subtle behavioral and psychiatric symptoms. The consequences of inadequate thyroid hormone availability to brain metabolism are poorly understood...
  26. ncbi Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder
    Dara M Cannon
    Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 62:870-7. 2007
    ....
  27. ncbi Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner
    Hugo W A M de Jong
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Phys Med Biol 52:1505-26. 2007
    ..2 cm. A high quantitative agreement was met between HR+ and HRRT clinical data. In conclusion, the ECAT HRRT has excellent resolution and sensitivity properties, which is a crucial advantage in many research studies...
  28. ncbi Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease
    Nicolaas I Bohnen
    Department of Radiology, Division of Nuclear Medicine, The University of Michigan Medical School, Ann Arbor, 48109 0028, USA
    J Cereb Blood Flow Metab 26:1198-212. 2006
    ..normal subjects underwent continuous intravenous infusion of (+)-[(11)C]dihydrotetrabenazine (DTBZ) and positron emission tomography (PET) imaging to estimate the striatal VMAT2 binding site density with equilibrium tracer modeling...
  29. ncbi Deactivation of the limbic system during acute psychosocial stress: evidence from positron emission tomography and functional magnetic resonance imaging studies
    Jens C Pruessner
    Center for Studies on Human Stress, Douglas Hospital Research Center and Montreal Neurological Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 63:234-40. 2008
    ..Newly developed paradigms to investigate stress in neuroimaging environments allow the assessment of brain activation changes in association with the perception of and the metabolic response to stress...
  30. ncbi MR-based automatic delineation of volumes of interest in human brain PET images using probability maps
    Claus Svarer
    Neurobiology Research Unit, University Hospital of Copenhagen, Rigshospitalet, N9201, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuroimage 24:969-79. 2005
    ..In addition, the method applies well in elderly subjects, even in the presence of pronounced cerebral atrophy...
  31. ncbi The maximum standardized uptake values on positron emission tomography of a non-small cell lung cancer predict stage, recurrence, and survival
    Robert James Cerfolio
    Section on Thoracic Surgery, University of Alabama at Birmingham, 1900 University Boulevard, THT 712, Birmingham, AL 35294, USA
    J Thorac Cardiovasc Surg 130:151-9. 2005
    ..We sought to assess whether the standard uptake value of a pulmonary nodule is an independent predictor of biologic aggressiveness...
  32. ncbi Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging
    Luuk J Rijzewijk
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 54:1524-32. 2009
    ....
  33. ncbi Four-dimensional (4D) PET/CT imaging of the thorax
    S A Nehmeh
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Med Phys 31:3179-86. 2004
    ..4D PET/CT acquisition can reduce smearing, improve the accuracy in PET-CT co-registration, and increase the measured SUV. This should result in an improved tumor assessment for patients with lung malignancies...
  34. pmc Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide
    Quang De Nguyen
    Comprehensive Cancer Imaging Center, Department of Oncology, Imperial College London Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W120NN, United Kingdom
    Proc Natl Acad Sci U S A 106:16375-80. 2009
    ....
  35. ncbi Early response assessment using 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography in high-grade non-Hodgkin's lymphoma
    Ken Herrmann
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Clin Cancer Res 13:3552-8. 2007
    To evaluate 3'-deoxy-3'-[(18)F]fluorothymidine-positron emission tomography (FLT-PET) for early monitoring response of high-grade non-Hodgkin's lymphoma to treatment with cyclophosphamide-adriamycin-vincristine-prednisone chemotherapy ..
  36. ncbi The impact of 68Ga-DOTATOC positron emission tomography/computed tomography on the multimodal management of patients with neuroendocrine tumors
    Andrea Frilling
    Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    Ann Surg 252:850-6. 2010
    To evaluate the impact of 68Ga-DOTATOC positron emission tomography (PET)/computed tomography (CT) on the multimodal management of neuroendocrine tumors (NET).
  37. ncbi Clinical implication and prognostic significance of standardised uptake value of primary non-small cell lung cancer on positron emission tomography: analysis of 176 cases
    Nael Al-Sarraf
    Department of Cardiothoracic Surgery, St James s Hospital, Dublin 8, Ireland Department of Thoracic Surgery, Chest Disease Hospital, Kuwait
    Eur J Cardiothorac Surg 34:892-7. 2008
    ..We sought to assess the clinical implication and prognostic significance of maximum standardised uptake value (SUV(max)) of primary non-small cell lung cancer (NSCLC) staged by integrated PET-CT...
  38. ncbi Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing Neoadjuvant chemoradiotherapy for rectal carcinoma: a pilot study
    David W Dietz
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 51:1641-8. 2008
    ....
  39. ncbi Stereotactic imaging for radiosurgery: localization accuracy of magnetic resonance imaging and positron emission tomography compared with computed tomography
    Yoshimasa Mori
    Nagoya Radiosurgery Center, Nagoya Kyoritsu Hospital, Nagoya, Japan
    Stereotact Funct Neurosurg 84:142-6. 2006
    Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) provide complementary information for treatment planning in stereotactic radiosurgery...
  40. ncbi Clinical outcomes of definitive intensity-modulated radiation therapy with fluorodeoxyglucose-positron emission tomography simulation in patients with locally advanced cervical cancer
    Elizabeth A Kidd
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 77:1085-91. 2010
    ..This study aimed to evaluate the toxicity and clinical outcomes for cervical cancer patients treated definitively with intensity-modulated radiation therapy (IMRT) compared with non-IMRT treatment...
  41. ncbi Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography
    Frederic Dolle
    CEA, Institut d Imagerie Biomédicale, Service Hospitalier Frederic Joliot, Orsay, France
    Curr Med Chem 16:2899-923. 2009
    ..high affinity, selective TSPO ligands in conjunction with functional imaging modalities such as positron emission tomography (PET), it becomes possible to study the process of microglial activation in the living brain...
  42. ncbi Consensus recommendations for the use of 18F-FDG PET as an indicator of therapeutic response in patients in National Cancer Institute Trials
    Lalitha K Shankar
    Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 47:1059-66. 2006
  43. pmc Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)
    Jessica B S Langbaum
    Banner Alzheimer s Institute and Banner Good Samaritan PET Center, Phoenix, AZ, USA
    Neuroimage 45:1107-16. 2009
    ..disease (AD) is associated with characteristic and progressive reductions in fluorodeoxyglucose positron emission tomography (PET) measurements of the regional cerebral metabolic rate for glucose (CMRgl)...
  44. ncbi Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography
    Timo Otonkoski
    Hospital for Children and Adolescents, and Program of Developmental and Reproductive Biology, Biomedicum Helsinki, Room C503b, PO Box 63, FIN 00014 University of Helsinki, Helsinki, Finland
    Diabetes 55:13-8. 2006
    ..We evaluated the utility of fluorine-18 l-3,4-dihydroxyphenylalanine ([(18)F]-DOPA) positron emission tomography (PET) to identify focal pancreatic lesions in 14 CHI patients, 11 of which carried mutations in the ..
  45. pmc Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans
    Tiffany M Love
    The Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Pl, Ann Arbor, MI 48109 0720, USA
    Arch Gen Psychiatry 66:1124-34. 2009
    ....
  46. pmc Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor
    Florian Bauer
    Department of Medicinal Chemistry, University of Vienna, Austria
    Bioorg Med Chem 18:5489-97. 2010
    The aim of this study was to develop a positron emission tomography (PET) tracer based on the dual P-glycoprotein (P-gp) breast cancer resistance protein (BCRP) inhibitor tariquidar (1) to study the interaction of 1 with P-gp and BCRP in ..
  47. ncbi Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides
    Rosalba Mansi
    Division of Radiological Chemistry, University Hospital Basel, Basel, Switzerland
    Clin Cancer Res 15:5240-9. 2009
    ..Here, we compare the new [111In/68Ga]-labeled bombesin-based antagonist RM1 with the agonist [111In]-AMBA for targeting the gastrin-releasing peptide receptor (GRPR)...
  48. ncbi Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria
    Haesun Choi
    Division of Diagnostic Imaging and Department of Sarcoma Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:1753-9. 2007
    ..whether computed tomography (CT) findings of GIST after imatinib treatment correlate with tumor responses by [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) and develops reliable, quantitative, CT response criteria.
  49. ncbi Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time?
    James H F Rudd
    Division of Cardiovascular Medicine, University of Cambridge, Cambridge, England
    J Am Coll Cardiol 55:2527-35. 2010
    ..b>Positron emission tomography imaging of atherosclerosis using the metabolic marker fluorodeoxyglucose allows quantification of ..
  50. ncbi Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkin's lymphoma and diffuse large B-cell lymphoma: a systematic review
    Teruhiko Terasawa
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA
    J Clin Oncol 27:1906-14. 2009
    To systematically review the prognostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) for interim response assessment of patients with untreated advanced-stage Hodgkin's lymphoma (HL) or diffuse large B-..
  51. ncbi Procedure guideline for tumor imaging with 18F-FDG PET/CT 1.0
    Dominique Delbeke
    Vanderbilt University Medical Center, Nashville, Tennessee 37232 2675, USA
    J Nucl Med 47:885-95. 2006
  52. pmc Combined FDG-PET/CT for the detection of unknown primary tumors: systematic review and meta-analysis
    Thomas C Kwee
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Radiol 19:731-44. 2009
    ..and meta-analyze published data on the diagnostic performance of combined 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in the detection of primary tumors in patients with cancer of unknown ..
  53. ncbi Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin alpha(v)beta3 expression in man
    Ambros J Beer
    Department of Nuclear Medicine, Lehrstuhl II für organische Chemie, Technische Universitat Munchen, Germany
    Clin Cancer Res 12:3942-9. 2006
    ..We have developed [18F]Galacto-RGD, a highly alpha(v)beta3-selective tracer for positron emission tomography (PET)...
  54. ncbi FDG-PET in the prediction of pathologic response after neoadjuvant chemoradiotherapy in locally advanced, resectable esophageal cancer
    Si Yeol Song
    Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea
    Int J Radiat Oncol Biol Phys 63:1053-9. 2005
    To assess the efficacy of 18Fluorodeoxyglucose-positron emission tomography (FDG-PET) for predicting a pathologic response in locally advanced esophageal cancer after neoadjuvant chemoradiotherapy.
  55. ncbi Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism
    Olga T Hardy
    Division of Endocrinology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 92:4706-11. 2007
    ..This study evaluated the accuracy of 18F-fluoro-l-dihydroxyphenylalanine ([18F]DOPA) positron emission tomography (PET) scans in diagnosing focal vs. diffuse disease and identifying the location of focal lesions.
  56. ncbi Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study
    Jeffrey H Meyer
    College Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 163:1594-602. 2006
    ..Striatal [(11)C]raclopride binding potential measured with positron emission tomography is an index of D(2) type receptors and is sensitive to extracellular dopamine levels (higher D(2) ..
  57. ncbi Whole-body (11)C-5-hydroxytryptophan positron emission tomography as a universal imaging technique for neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and computed tomography
    H Orlefors
    Department of Medical Sciences Endocrine Oncology, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 90:3392-400. 2005
    ..Our objective was to investigate whether whole-body (WB) positron emission tomography (PET) with (11)C-5-hydroxytryptophan (5-HTP) can be used as a universal imaging technique for NETs and ..
  58. ncbi Congenital hyperinsulinism: pancreatic [18F]fluoro-L-dihydroxyphenylalanine (DOPA) positron emission tomography and immunohistochemistry study of DOPA decarboxylase and insulin secretion
    Pascale de Lonlay
    Departement de Pediatrie, Hopital Necker Enfants Malades, Universite Paris Descartes, Faculte de Medecine, 149 rue de Sevres, 75743 Paris Cedex 15, France
    J Clin Endocrinol Metab 91:933-40. 2006
    ..Preoperative differential diagnosis was based on pancreatic venous sampling, a technically demanding technique...
  59. ncbi Use of [18F]fluorodeoxyglucose positron emission tomography in evaluating locally recurrent and metastatic adrenocortical carcinoma
    Gavin C Mackie
    Department of Radiological Sciences, St Jude Children s Research Hospital, 332 North Lauderdale, Mail Stop 752, Memphis, Tennessee 38105 2794, USA
    J Clin Endocrinol Metab 91:2665-71. 2006
    Adrenocortical carcinomas are uncommon, and their evaluation by [(18)F]fluorodeoxyglucose positron emission tomography (FDG PET) has not been well evaluated.
  60. ncbi Imaging early changes in proliferation at 1 week post chemotherapy: a pilot study in breast cancer patients with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography
    Laura Kenny
    Imperial College London, and Hammersmith Hospital NHS Trust, London, UK
    Eur J Nucl Med Mol Imaging 34:1339-47. 2007
    3'-deoxy-3'-[18F]fluorothymidine positron emission tomography ([18F]FLT-PET) has been developed for imaging cell proliferation and findings correlate strongly with the Ki-67 labelling index in breast cancer...
  61. ncbi The predictive value of positron emission tomography scanning performed after two courses of standard therapy on treatment outcome in advanced stage Hodgkin's disease
    Andrea Gallamini
    SC Ematologia Azienda, Ospedaliera S Croce e Carle, Cuneo, Italy
    Haematologica 91:475-81. 2006
    ....
  62. ncbi Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: a combined alpha-[11C]MT and [18F]MPPF positron emission tomography study
    Benicio N Frey
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Neuroimage 42:850-7. 2008
    ..study aims to assess the correlation between serotonin synthesis and 5-HT(1A) receptor binding using positron emission tomography (PET) in humans...
  63. ncbi [18F]galacto-RGD positron emission tomography for imaging of alphavbeta3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck
    Ambros J Beer
    Department of Nuclear Medicine, Technische Universitat Munchen, Klinikum rechts der Isar, Ismaninger Strasse 22, Munich, Germany
    Clin Cancer Res 13:6610-6. 2007
    18)F]Galacto-RGD has been developed for positron emission tomography (PET)-imaging of alphavbeta3 expression, a receptor involved in angiogenesis and metastasis...
  64. pmc Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, 31 Center Drive, MSC 2035, Bethesda, MD 20892 2035, USA
    Neuroimage 40:43-52. 2008
    ..In conclusion, with the exception of those subjects who appeared to have no PBR binding, [(11)C]PBR28 is a promising ligand to quantify PBRs and localize inflammation associated with increased densities of PBRs...
  65. pmc Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments
    Vania Kenanova
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA, USA
    Cancer Res 65:622-31. 2005
    ..H310A, and H310A/H435Q variants were evaluated in LS174T xenografted athymic mice by small animal positron emission tomography imaging, revealing localization to the CEA-positive xenografts...
  66. ncbi Assessment of alphavbeta3 integrin expression after myocardial infarction by positron emission tomography
    Takahiro Higuchi
    Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munich, Germany
    Cardiovasc Res 78:395-403. 2008
    The purpose of this study was to determine the feasibility of a new positron emission tomography (PET) imaging approach using an (18)F-labelled alpha(v)beta(3) integrin antagonist ((18)F-Galacto-RGD) to monitor the integrin expression ..
  67. pmc Positron emission tomography has a high negative predictive value for progression or early relapse for patients with residual disease after first-line chemotherapy in advanced-stage Hodgkin lymphoma
    Carsten Kobe
    Department of Nuclear Medicine, University of Cologne, Cologne, Germany
    Blood 112:3989-94. 2008
    In the HD15 trial of the German Hodgkin Study Group, the negative predictive value (NPV) of positron emission tomography (PET) using [(18)F]-fluorodeoxyglucose in advanced-stage Hodgkin lymphoma (HL) was evaluated...
  68. ncbi Positron emission tomography: a real-time tool to quantify early islet engraftment in a preclinical large animal model
    Torsten Eich
    Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, University Hospital, Uppsala, Sweden
    Transplantation 84:893-8. 2007
    ..Therefore, the objective of the present study was to develop a technique for imaging survival of transplanted islets in the peritransplant and early posttransplant phase...
  69. ncbi A pathophysiologic study of tako-tsubo cardiomyopathy with F-18 fluorodeoxyglucose positron emission tomography
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Gifu Prefectural Government TAJIMI Hospital, 5 161 Maehata, Tajimi, Gifu 5078522, Japan
    Eur Heart J 28:2598-604. 2007
    AIMS; Our study aims to investigate the pathophysiologic mechanism underlying tako-tsubo cardiomyopathy using F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET).
  70. ncbi Circulating tumor cells and [18F]fluorodeoxyglucose positron emission tomography/computed tomography for outcome prediction in metastatic breast cancer
    Ugo De Giorgi
    The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Clin Oncol 27:3303-11. 2009
    Circulating tumor cells (CTCs) and [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) are two new promising tools for therapeutic monitoring...
  71. pmc Molecular imaging of cancer with copper-64 radiopharmaceuticals and positron emission tomography (PET)
    Monica Shokeen
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Acc Chem Res 42:832-41. 2009
    ..b>Positron emission tomography (PET) is widely used by clinicians in the United States as a diagnostic molecular imaging tool...
  72. pmc Early detection of erlotinib treatment response in NSCLC by 3'-deoxy-3'-[F]-fluoro-L-thymidine ([F]FLT) positron emission tomography (PET)
    Roland T Ullrich
    Max Planck Institute for Neurological Research with Klaus Joachim Zülch Laboratories of the Max Planck Society, Medical Faculty of the University of Cologne, Cologne, Germany
    PLoS ONE 3:e3908. 2008
    ..However, imaging approaches affording early identification of tumor response in EGFR-dependent carcinomas have so far been lacking...
  73. ncbi Positron emission tomography in clinical islet transplantation
    O Eriksson
    Department of Radiology, Oncology and Clinical Immunology, Division of Radiology, University Hospital, Uppsala, Sweden
    Am J Transplant 9:2816-24. 2009
    The fate of islets in clinical transplantation is unclear. To elude on this positron emission tomography combined with computed tomography (PET/CT) was performed for 60 min during islet transplantation in five patients receiving six ..
  74. pmc Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery
    John Terrovitis
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Am Coll Cardiol 54:1619-26. 2009
    The aim of this study was to quantify acute myocardial retention of cardiac-derived stem cells (CDCs) and evaluate different delivery methods with positron emission tomography (PET).
  75. ncbi Relationship between regional myocardial oxygenation and perfusion in patients with coronary artery disease: insights from cardiovascular magnetic resonance and positron emission tomography
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom
    Circ Cardiovasc Imaging 3:32-40. 2010
    ..magnetic resonance (CMR) has the potential to noninvasively measure myocardial oxygenation, whereas positron emission tomography (PET) with oxygen-15 labeled water is the gold standard technique for myocardial blood flow ..
  76. ncbi Imaging of tumor glucose utilization with positron emission tomography
    Andrea Buerkle
    Department of Nuclear Medicine, University of Freiburg, Freiburg, Germany
    Cancer Metastasis Rev 27:545-54. 2008
    In recent years, imaging of tumor glucose metabolism with positron emission tomography and fluorodeoxyglucose (FDG-PET) has become a routine test for detection, staging and restaging of malignant lymphomas and many solid tumors...
  77. ncbi Improvements in cancer staging with PET/CT: literature-based evidence as of September 2006
    Johannes Czernin
    Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic Nuclear Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 6948, USA
    J Nucl Med 48:78S-88S. 2007
    ..From these data, we believe, has emerged reliable evidence in support of the notion that PET/CT offers diagnostic advantages over its individual components for the major cancers...
  78. pmc Pretargeted immuno-positron emission tomography imaging of carcinoembryonic antigen-expressing tumors with a bispecific antibody and a 68Ga- and 18F-labeled hapten peptide in mice with human tumor xenografts
    Rafke Schoffelen
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Cancer Ther 9:1019-27. 2010
    ..b>Positron emission tomography (PET)/computed tomography images reinforced the improved specificity of the pretargeting method...
  79. ncbi Altered regional cerebral glucose metabolism in internet game overusers: a 18F-fluorodeoxyglucose positron emission tomography study
    Hyun Soo Park
    Seoul National University College of Medicine, South Korea
    CNS Spectr 15:159-66. 2010
    ..we investigated the differences in regional cerebral glucose metabolism at resting state between young individuals with Internet game overuse and those with normal use using 18F-fluorodeoxyglucose positron emission tomography study.
  80. ncbi Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography
    John Terrovitis
    Department of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Coll Cardiol 52:1652-60. 2008
    ..NIS), which promotes in vivo cellular uptake of technetium 99m ((99m)Tc) or iodine 124 ((124)I), as a reporter gene for cell tracking by single-photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging.
  81. pmc Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography
    Sridhar Nimmagadda
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 70:3935-44. 2010
    ..Our findings show the feasibility of imaging CXCR4 by positron emission tomography using a clinically approved agent as a molecular scaffold.
  82. ncbi Impact of positron emission tomography/computed tomography and positron emission tomography (PET) alone on expected management of patients with cancer: initial results from the National Oncologic PET Registry
    Bruce E Hillner
    Department of Internal Medicine and the Massey Cancer Center, Virginia Commonwealth University, 1101 E Marshall St, Room 7013, Richmond, VA 23298 0170, USA
    J Clin Oncol 26:2155-61. 2008
    Under Medicare's Coverage with Evidence Development policy, positron emission tomography (PET)/computed tomography (CT) and PET became covered services for previously noncovered cancer indications if prospective registry data were ..
  83. ncbi Functional brown adipose tissue in healthy adults
    Kirsi A Virtanen
    Turku PET Center, University of Turku, Finland
    N Engl J Med 360:1518-25. 2009
    ....
  84. pmc High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity
    Masayuki Saito
    Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo, Japan
    Diabetes 58:1526-31. 2009
    ..The objective is to examine the prevalence of metabolically active BAT in healthy adult humans and to clarify the effects of cold exposure and adiposity...
  85. ncbi Quantitative fluoroestradiol positron emission tomography imaging predicts response to endocrine treatment in breast cancer
    Hannah M Linden
    Division of Medical Oncology, University of Washington, Seattle Cancer Care Alliance, Seattle, WA 98109, USA
    J Clin Oncol 24:2793-9. 2006
    In breast cancer, [(18)F]fluoroestradiol (FES) positron emission tomography (PET) correlates with estrogen receptors (ER) expression and predicts response to tamoxifen...
  86. pmc Neurophysiological responses to traumatic reminders in the acute aftermath of serious motor vehicle collisions using [15O]-H2O positron emission tomography
    Elizabeth A Osuch
    Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
    Biol Psychiatry 64:327-35. 2008
    ..However, neural responses arising in the early aftermath of a traumatic event have not been studied...
  87. ncbi Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography
    Conny J van der Laken
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 58:3350-5. 2008
    Noninvasive imaging by positron emission tomography (PET) of macrophages in inflamed joints of patients with rheumatoid arthritis (RA) may allow early detection of disease activity...
  88. ncbi Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy
    Frank Willi Floeth
    Department of Neurosurgery, Heinrich Heine University, Dusseldorf, Germany
    J Neurosurg 102:318-27. 2005
    The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas.
  89. ncbi Neural correlates of intelligibility in speech investigated with noise vocoded speech--a positron emission tomography study
    Sophie K Scott
    Department of Psychology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Acoust Soc Am 120:1075-83. 2006
    ..Specifically, it is suggested that an anterior stream processing intelligibility can be distinguished from a posterior stream associated with transient representations, important in spoken repetition and working memory...
  90. ncbi Usefulness of positron emission tomography in the evaluation of distribution and activity of systemic lesions associated with autoimmune pancreatitis
    Hiroyuki Matsubayashi
    Division of Endoscopy, Shizuoka Cancer Center, Suntogun, Japan
    Pancreatology 9:694-9. 2009
    ..The aim of this study is to analyze the usefulness of positron emission tomography with (18)F-fluorodeoxyglucose (FDG-PET) in the evaluation of distribution and activity of systemic ..
  91. ncbi Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Ontario, Canada
    J Med Chem 48:4153-60. 2005
    ..carbon-11, as a potential radiotracer for imaging the high-affinity state of dopamine D2 receptors with positron emission tomography (PET)...
  92. ncbi Use of 18F-fluorodeoxyglucose positron emission tomography for diagnosis of uterine sarcomas
    Akira Nagamatsu
    Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama 641 8509, Japan
    Oncol Rep 23:1069-76. 2010
    We evaluated the use of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) for the diagnosis of uterine sarcomas...
  93. ncbi FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease
    Norman L Foster
    Center for Alzheimer s Care, Imaging and Research and Department of Neurology, University of Utah, USA
    Brain 130:2616-35. 2007
    ..AD) and frontotemporal dementia (FTD) currently relies on a clinical history and examination, but positron emission tomography with [(18)F] fluorodeoxyglucose (FDG-PET) shows different patterns of hypometabolism in these disorders ..
  94. ncbi Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin's lymphoma
    Heiko Schoder
    Memorial Sloan Kettering Cancer Center, Department of Radiology, Nuclear Medicine Service, Box 77, 1275 York Avenue, New York, NY 10021, USA
    J Clin Oncol 23:4643-51. 2005
    18)Fluorodeoxyglucose positron emission tomography (FDG PET) is widely used for the staging of lymphoma. We investigated whether the intensity of tumor FDG uptake could differentiate between indolent and aggressive disease.
  95. ncbi The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma
    Yan Li
    Division of Surgical Oncology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Cancer Invest 26:278-85. 2008
    ....
  96. ncbi Blood flow-metabolic relationships are dependent on tumour size in non-small cell lung cancer: a study using quantitative contrast-enhanced computer tomography and positron emission tomography
    K A Miles
    Division of Clinical and Laboratory Sciences, Brighton and Sussex Medical School, University of Sussex, Brighton, BN7 3PB, UK
    Eur J Nucl Med Mol Imaging 33:22-8. 2006
    ..lung cancer (NSCLC) using contrast-enhanced computed tomography (CE-CT) and (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in order to assess how the relationships between these parameters vary with tumour size and ..
  97. ncbi Prognostic value of metabolic tumor volume measured by 18F-fluorodeoxyglucose positron emission tomography in patients with esophageal carcinoma
    Seung Hyup Hyun
    Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Ann Surg Oncol 17:115-22. 2010
    The aim of this study was to evaluate the prognostic value of metabolic tumor volume (MTV) measured by (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in patients with esophageal carcinoma.
  98. ncbi Usefulness 18F-FDG positron emission tomography/computed tomography for detecting recurrence of hepatocellular carcinoma in posttransplant patients
    Young Kyu Kim
    Center for Liver Cancer, Goyang si, Gyeonggi Do, Republic of Korea
    Liver Transpl 16:767-72. 2010
    18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) has recently been shown to be able to predict a poor outcome after liver transplantation (LT) for patients with hepatocellular ..
  99. ncbi Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography
    Philip W Miller
    Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK
    Angew Chem Int Ed Engl 47:8998-9033. 2008
    b>Positron emission tomography (PET) is a powerful and rapidly developing area of molecular imaging that is used to study and visualize human physiology by the detection of positron-emitting radiopharmaceuticals...
  100. ncbi FDG-PET imaging for chronic expanding hematoma in pelvis with massive bone destruction
    Kenichiro Hamada
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Skeletal Radiol 34:807-11. 2005
    ..2-Deoxy-[18F]fluoro-D: -glucose (FDG) positron emission tomography (PET) imaging revealed an increased uptake in the rim of the mass in images acquired 1 h after FDG ..
  101. ncbi Simultaneous PET-MRI: a new approach for functional and morphological imaging
    Martin S Judenhofer
    Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens Foundation, Department of Radiology, Eberhard Karls University of Tubingen, Röntgenweg 13, 72076 Tubingen, Germany
    Nat Med 14:459-65. 2008
    ..This paper introduces a new technology synergizing two leading imaging methodologies: positron emission tomography (PET) and magnetic resonance imaging (MRI)...

Research Grants77

  1. Positron Emission Tomography to Evaluate Thymic Function
    Laura Napolitano; Fiscal Year: 2006
    ..of fluorine-18 fluorodeoxyglucose by thymic tissue has been previously detected and quantitated by positron emission tomography (PET)...
  2. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    ....
  3. Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue
    JAMES RUSSELL SOWERS; Fiscal Year: 2013
    ..utilize our state of the art rodent imaging center to conduct critical in vivo investigations, employ positron emission tomography (PET) scanning to evaluate insulin stimulated glucose uptake in the heart, and cine-magnetic resonance ..
  4. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..b>Positron emission tomography (PET scan) can create image of the harmful beta amyoid plaque in the brains of living Alzheimer's ..
  5. Neural mechanisms by which chronic stress regulates inflammation in asthma
    Melissa A Rosenkranz; Fiscal Year: 2013
    ..All participants will perform a psychosocial stress test. Positron emission tomography (PET) will be used to measure the neural response to the stressor, such that uptake of radiolabeled ..
  6. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    ..sequence of procedures: (1) telephone/in-person screening, (2) a bolus-plus-continuous-infusion 2- FA positron emission tomography (PET) scanning session, (3) a structural magnetic resonance imaging scan within one week of the initial ..
  7. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..This changed with the development by our laboratory of a novel, innovative and non-invasive, Positron Emission Tomography (PET) imaging method to quantitatively measure P-gp activity and its inhibition/induction at the human ..
  8. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..abstract_text> ..
  9. Neuroimaging Assessments of Brain Integrity in Aging Mice
    Ai Ling Lin; Fiscal Year: 2013
    ..non-invasive brain imaging methods (magnetic resonance imaging and spectroscopy (MRI/MRS) and positron emission tomography (PET)) to assess brain metabolic, hemodynamic and neuronal (structural and functional) integrity and ..
  10. NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
    Vijay Sharma; Fiscal Year: 2013
    ..By comparison, positron emission tomography (PET) provides technical advantages, including higher spatial resolution, improved attenuation ..
  11. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..To do this, we aim to use functional magnetic resonance imaging (fMRI) and [11C]raclopride Positron Emission Tomography (PET) during a physiological challenge (monetary reward task) and a pharmacological challenge, (d-..
  12. Early social stress, novelty seeking, and impulsive behavior
    David M Lyons; Fiscal Year: 2013
    ..Diminished ventral striatal DRD2 availability determined in vivo by positron emission tomography (PET) has been linked in humans and animal models to novelty seeking and related maladaptive forms of ..
  13. Nitric Oxide in Pulmonary Hypertension
    Serpil C Erzurum; Fiscal Year: 2013
    ..ascribed to HIF-expression [increased lung glucose uptake by 18F- fluoro-deoxy-glucose analogue - positron emission tomography (FDG-PET), high-levels of plasma erythropoietin (Epo) and mobilization of bone marrow progenitors] are ..
  14. T-cell Therapy for B-lineage Acute Lymphoblastic Leukemia
    Laurence J N Cooper; Fiscal Year: 2013
    ..electroporation to introduce the CAR as well as co-express HSV-1 thymidine kinase (TK) for imaging by positron emission tomography (PET)...
  15. Pulmonary Vascular-Right Ventricular Axis Research Program
    Wai Hong Wilson Tang; Fiscal Year: 2013
    ..by glycolytic enzyme expression and uptake of the glucose analogue [18F]2-fluoro-2-deoxy-D-glucose by positron emission tomography (fasting FDG-PET) in PAH patients...
  16. Quantitative Assessment of Oxidative Metabolism in Brown Fat
    Otto Muzik; Fiscal Year: 2011
    ..Recently, numerous papers have appeared in the positron emission tomography (PET) literature identifying symmetric foci of intense uptake of 18F-deoxy-D-glucose (FDG) uptake in ..
  17. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..This 5 year study, of women 18 to 45 years old, will employ positron emission tomography (PET) imaging with radioligands for the serotonin (5-HT) transporter ([11C]DASB) and dopamine (DA) D2/..
  18. Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine Disease
    Thomas J Meade; Fiscal Year: 2013
    ..MRI does not use ionizing radiation or radioactivity like positron emission tomography (PET) and X-ray/CT, and it allows for 3D reconstructions and high resolution imaging over time without ..
  19. Brain Nicotine Receptor Density &Response to Nicotine Patch
    Arthur Brody; Fiscal Year: 2013
    ..Pilot data from our ongoing studies using positron emission tomography (PET) and the radiotracer 2-[18F]fluoro-3-(2(S)azetidinylmethoxy) pyridine (abbreviated as 2-FA) in ..
  20. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..Relevant to the role of DA and the basal ganglia in these effects, neuroimaging studies using positron emission tomography (PET) in patients undergoing IFN-alpha therapy have revealed increased basal ganglia glucose metabolism ..
  21. Cardiac Autonomic Neuropathy and Myocardial Dysfunction in Type 1 Diabetes
    RODICA BUSUI POP-BUSUI; Fiscal Year: 2013
    ..The manifestations of sympathetic activation will be determined by positron emission tomography (PET) with [11C]meta-hydroxyephedrine ([11C]HED), heart rate variability, and 24-hour blood pressure ..
  22. Using PET isotopes to identify drug targets and to diagnose infectious diseases
    Peter J Tonge; Fiscal Year: 2010
    b>Positron emission tomography (PET) radioisotopes, such as carbon-11 (11C) and fluorine-18 (18F), will be incorporated into current antibiotics, such as the tuberculosis drugs isoniazid and rifampicin, in order to directly identify the ..
  23. In vivo imaging of encapsulated stem cells in mouse models of tumor resection
    Khalid A Shah; Fiscal Year: 2013
    ..and their efficacy by in vivo BLI, intravital microscopy (IVM), magnetic resonance imaging (MRI) and positron emission tomography (PET) and thus to fine tune the proposed approaches...
  24. PET Imaging of Thrombus
    PETER D CARAVAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Positron Emission Tomography Imaging of Thrombus. The goal of this proposal is to develop a fibrin-specific positron emission tomography (PET) probe for direct imaging of thrombus...
  25. Changes in Adipokines and Adiposity during Puberty and Young Adulthood
    NICOLE LENORE MIHALOPOULOS; Fiscal Year: 2013
    ..measures will be determined in 600 subjects (8-99yo) who are undergoing a clinically indicated positron emission tomography with computed tomography (PET/CT)...
  26. Targeting Glucose Metabolism in Cancer
    Sucheta Telang; Fiscal Year: 2013
    ..This metabolic phenotype is confirmed by positron emission tomography (PET) with 2-[18F]-fluoro-2-deoxy-glucose which demonstrates that tumors take up 10-fold more glucose ..
  27. ASCORBATE-INDUCED RADIOSENSITIZATION IN PANCREATIC CANCER
    Joseph J Cullen; Fiscal Year: 2013
    ..and oxidative stress in vitro and in vivo;we will employ FLT-PET (fluoro-labeled thymidine positron emission tomography) as a non- invasive in vivo index of cell proliferation...
  28. The Neurochemistry of Cognitive Therapy: Predicting Treatment Outcome with PET
    Jeffrey M Miller; Fiscal Year: 2013
    ..We will quantify the 5-HT1A receptor at baseline using positron emission tomography (PET) with the [11C]WAY-100635 radioligand among 46 subjects with MDD in a major depressive episode, ..
  29. Predicting Cognitive Decline in Adults with Down Syndrome
    Ira T Lott; Fiscal Year: 2013
    ..The 2nd specific aim will assess whether amyloid uptake is increased in brain by positron emission tomography as a predictor of dementia...
  30. RCT of Stress Reduction in the Secondary Prevention of CHD in African Americans
    Robert Schneider; Fiscal Year: 2010
    ..b>Positron emission tomography (PET) is a highly sensitive and specific noninvasive tool for quantifying changes in coronary artery ..
  31. New Inactivators of GABA Aminotransferase for Addiction
    Richard B Silverman; Fiscal Year: 2013
    ..It was shown by positron emission tomography (PET) in primates that vigabatrin inhibits these cocaine-induced dopamine increases...
  32. Brown Adipose Tissue Vasculature Probes for Non-Invasive Imaging
    Mikhail G Kolonin; Fiscal Year: 2011
    ..Recently, functional BAT in adult humans has been detected by positron emission tomography (PET), outlining new avenues in treatment of obesity and the associated disorders...
  33. PSMA-based Cancer Imaging Agents
    Martin G Pomper; Fiscal Year: 2013
    ..Metabolic imaging techniques such as magnetic resonance spectroscopy (MRS), positron emission tomography (PET) and single photon emission computed tomography (SPECT) are gaining favor over the anatomic ..
  34. IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHY
    Shahriar Yaghoubi; Fiscal Year: 2013
    ..and microenvironment associated with adoptively transferred CD19-specific T cells as achieved using positron emission tomography (PET)...
  35. Cathespin K Radioligands for In Vivo Imaging
    Michael R Kilbourn; Fiscal Year: 2012
    ..project involves the design, development and evaluation of an new molecular imaging radiotracers for Positron Emission Tomography (PET) studies of osteoporosis and other musculoskeletal diseases (e.g...
  36. BETR Therapy for Herpesvirus-Associated Tumors
    Martin G Pomper; Fiscal Year: 2013
    ..EBV-associated lymphoma and nasopharygeal carcinoma with bortezomib then image them with [124I]FIAU and positron emission tomography, using the imaging to guide treatment with [131I]FIAU...
  37. TWIN STUDY OF BIOLOGIC MARKERS FOR PTSD
    Lisa M Shin; Fiscal Year: 2012
    ..cerebral blood flow during script-driven imagery of combat and other personal stressful events during positron emission tomography, and e...
  38. DEVELOPMENT AND REGULATION OF EMOTION IN PRIMATES
    Ned H Kalin; Fiscal Year: 2013
    ..and influences on the serotonin system indexed by serotonin 1A (5HT1A) binding, measured with in vivo positron emission tomography (PET) of dorsal raphe and hippocampus...
  39. Biologic Evaluation of Liposome-Encapsulated Hemoglobin
    Vibhudutta Awasthi; Fiscal Year: 2013
    ..Improvement in cerebral oxygen, glucose and energy metabolism will be evaluated by positron emission tomography and magnetic resonance imaging...
  40. Imaging Biomarkers for Evaluating Mitochondrial Function in Diabetes
    Geoffrey David Clarke; Fiscal Year: 2013
    ..Also, positron emission tomography has been used extensively to measure glucose utilization and tissue blood flow in skeletal muscle...
  41. Effect of Circulating Glucose on Eating Behavior and Brain Activation in Diabetes
    RENATA D BELFORT DE AGUIAR; Fiscal Year: 2013
    ..brain metabolism and function including: a) use of brain imaging techniques (fMRI, MRI spectroscopy and positron emission tomography - all available at Yale University);and b) behavioral measurements (visual cues with fMRI, ..
  42. Hyperpolarized 129-Xenon-based MRI Probes for Brain Injury
    JEREMY PHILLIP CELVER; Fiscal Year: 2010
    ..The sensitivity of positron emission tomography (PET) and single photon emission computed tomography (SPECT) have led to the widespread use of these ..
  43. Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down's Syndrome and Dementia
    GARY WILLIAM SMALL; Fiscal Year: 2013
    ..5 million people in the U.S. Our pilot positron emission tomography (PET) studies of adults with DS show lower brain glucose metabolic rates (measured with ..
  44. The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
    ROBERT STANLEY SHERWIN; Fiscal Year: 2012
    ..The purpose of this application is to test a new, mechanistically driven approach using positron emission tomography (PET) imaging of BAT in humans...
  45. Functional Genomics and Molecular Imaging of Liver Disease and Cancer
    GORDON SHOJI OKIMOTO; Fiscal Year: 2013
    ..imaging techniques that can be applied clinically to HCC and chronic liver disease, and has identified Positron Emission Tomography (PET) as a promising technology that may address some of these issues...
  46. PET and MRI Neuronal Loss and Amyloid and Tau Deposition in Alzheimer Disease
    Laurel Martin-Harris; Fiscal Year: 2012
    ..combines high resolution magnetic resonance imaging (MRI) of the hippocampal complex (HC) with two positron emission tomography (PET) techniques to investigate the relationship between protein deposition, HC neuronal loss and ..
  47. Epidemiology of Biomarkers of Risk and Progression in LOAD
    Nicole Schupf; Fiscal Year: 2013
    ..b>Positron emission tomography brain imaging using 11C Pittsburgh compound B is considered an in vivo measure of brain amyloid plaque ..
  48. Cytokine Effects on Amphetamine-Induced Dopamine Release using PET Neuroimaging
    Jennifer C Felger; Fiscal Year: 2011
    ..In addition, neuroimaging studies using positron emission tomography (PET) in patients undergoing IFN-alpha therapy have revealed increased basal ganglia glucose metabolism ..
  49. Exploiting Protease-Activatable Agents to Characterize and Treat Asthma
    Csilla Felsen; Fiscal Year: 2013
    ..ACPPs with fluorescent and/or non-optical (e.g., 64Cu for positron emission tomography) imaging payloads will be used for longitudinal in vivo imaging of mice at various stages of asthma ..
  50. IMAGING AUTOIMMUNE DISEASE
    Diane J Mathis; Fiscal Year: 2013
    ..and visualization methods [magnetic resonance imaging (MRI)/positron emission tomography (PET)/confocal and intravital microscopy (IVM)/fluorescence-mediated tomography (FMT), fluorescent-..
  51. Imaging Cellular Stress and Treatment Response Using Positron Emission Tomography
    ANTHONY FRANK SHIELDS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Positron emission tomography (PET) allows one to measure tumor and normal tissue metabolism in vivo and non-invasively...
  52. MULTI-TISSUE MULTI-TRACER METABOLIC PHENOTYPING OF DIABETES WITH PRE-CLINICAL PET
    KOORESH ISAAC SHOGHI; Fiscal Year: 2013
    ..metabolic imaging in multi-tissues using multiple metabolic tracers in conjunction with pre-clinical Positron Emission Tomography (PET). Pre-clinical PET is unique in that multiple tissues are in the field-of-view (FOV)...
  53. The Use of 2-Deoxyglucose in Head and Neck Cancer Therapy
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2013
    ..of these observations has been limited to the use of 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG) and Positron Emission Tomography (PET) to identify cancerous tissues...
  54. DEVELOPMENT OF PET RADIOPHARMACEUTICALS TARGETING GRPR
    Buck E Rogers; Fiscal Year: 2012
    ..radiolabeled BN analogs have been evaluated for single photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging of GRPR-expressing cancers...
  55. A Proof of Concept Study Examining The Safety and Efficacy of Innate Immune Syste
    Ted T Ashburn; Fiscal Year: 2013
    ..immune system stimulation with sargramostim on existing beta-amyloid plaque load using quantitative positron emission tomography (PET) in patients with mild cognitive impairment (MCI) due to AD (pre-clinical AD)...
  56. 18F-Mefway PET for Human Aging and Alzheimer's Disease
    Jogeshwar Mukherjee; Fiscal Year: 2013
    ..Our long-term goal is to develop noninvasive imaging methods of positron emission tomography (PET) that will aid in the early diagnosis of these disorders and may therefore be useful in treatment ..
  57. Comparative effectiveness of noninvasive cardiac imaging
    Marcelo F Di Carli; Fiscal Year: 2010
    ..SPECT), newer imaging technology including coronary computed tomography angiography (CCTA), and positron emission tomography (PET) are receiving considerable attention with the goal of improving diagnosis and risk stratification ..
  58. [F18]FMAU in Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
    ..results from other researchers have prompted us to investigate the potential diagnostic utility of positron emission tomography (PET) with [F- 18]-2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (F-18 FMAU) in the imaging ..
  59. Novel molecular imaging approaches to monitor gene and cell-based therapies
    Shahriar Yaghoubi; Fiscal Year: 2013
    ..technologies for specific identification and tracking of therapeutic genes and cells in vivo using positron emission tomography (PET), a quantitative, non-invasive molecular imaging approach applicable to both preclinical and ..
  60. MR-PET for a Small Animal Imaging Center
    Jason A Koutcher; Fiscal Year: 2010
    ..09-004) will focus on "Comparative Oncology Research" and requests funds for a unique state of the art Positron Emission Tomography (PET) insert for an MR animal scanner which will be used by numerous biomedical research laboratories ..
  61. Detection of Brown Adipose Tissue Using Contrast Ultrasound
    Marielle Scherrer-Crosbie; Fiscal Year: 2012
    ..There are however difficulties associated with studying BAT in vivo. 18F-fluorodeoxyglucose positron emission tomography coupled with CT scan (18F-FDG PET-CT) is currently the only technology available to detect human BAT in ..
  62. Radiolabled MAO-B Substrates for Imaging
    Michael R Kilbourn; Fiscal Year: 2012
    ..synthesis, and evaluation in vitro and in vivo of new carbon-11 and fluorine-18 labeled substrates for Positron Emission Tomography (PET) imaging of MAO-B enzymatic activity...
  63. HPLC-ICP-MS System
    PETER D CARAVAN; Fiscal Year: 2013
    ..translational research involving advanced imaging techniques such as magnetic resonance imaging (MRI), positron emission tomography, optical imaging, and magnetoencephalography. Accurate elemental analysis underpins much of this work...
  64. Development of Novel Fluorinated Amino Acids
    Mark Goodman; Fiscal Year: 2004
    ..to image brain and systemic tumors in vivo based upon amino acid transport with the imaging technique Positron Emission Tomography (PET)...
  65. FDG-PET and V/Q SPECT Acquired During Radiation to Predict Outcomes in Lung Cance
    Feng Ming Kong; Fiscal Year: 2009
    ..Using [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) and ventilation/perfusion single photon emission computed tomography (V/Q SPECT), we have ..
  66. Recombinant Human TSH Superagonists for Imaging of Thyroid Cancer
    Bruce Weintraub; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  67. Nitric Oxide in Pulmonary Hypertension
    Serpil Erzurum; Fiscal Year: 2009
    ..ascribed to HIF-expression [increased lung glucose uptake by 18F- fluoro-deoxy-glucose analogue - positron emission tomography (FDG-PET), high-levels of plasma erythropoietin (Epo) and mobilization of bone marrow progenitors] are ..
  68. A Phase II Study to Test the Correlation of a Radiation Pneumonitis Imaging Bioma
    Thomas M Guerrero; Fiscal Year: 2010
    ..18F]-2-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET) imaging provides an assessment of pneumonitis, pulmonary inflammation appears as enhanced ..
  69. In Vivo Optical Imaging Scanner for Small Animal Research
    STUART BERR; Fiscal Year: 2009
    ..planar fluorescence and bioluminescence imaging (BLI), single gamma emission tomography (SPECT), and positron emission tomography (PET) scanners...
  70. Assessment of Brain Iron and Neuronal Integrity Using Novel T1r and T2r MRI
    Shalom Michaeli; Fiscal Year: 2009
    ..Current radiotracing imaging techniques such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) lack the ability to ascertain dopamine ..
  71. ANESTHETIC MECHANISMS BY IN VIVO BRAIN IMAGING
    Ferenc Gyulai; Fiscal Year: 2004
    b>Positron emission tomography (PET) permits the study of neuroreceptor systems non-invasively in the living brain, and thus offers a means to define the neurophysiological basis of unconsciousness produced by general anesthetics...
  72. Quantitative periprosthetic PET/CT
    Thomas Lang; Fiscal Year: 2009
    ..Both Computed Tomography (CT) and Positron Emission Tomography (PET) have been recognized as potential diagnostic alternatives with excellent sensitivity and ..
  73. Development and Applications of Novel SERT PET Ligands
    Mark Goodman; Fiscal Year: 2006
    ..the exploration of the mechanism of major depression by assessing the functional status of SERT using Positron Emission Tomography (PET)...
  74. Development and Applications of Novel SERT PET Ligands
    Mark Goodman; Fiscal Year: 2004
    ..the exploration of the mechanism of major depression by assessing the functional status of SERT using Positron Emission Tomography (PET)...
  75. PET IN HYPERKINETIC DISORDERS--A MULTICENTER STUDY
    David Eidelberg; Fiscal Year: 2001
    ..New advances in functional brain imaging with positron emission tomography (PET) and network analysis have allowed us to identify and quantitate spatially distributed changes in ..
  76. PET/SPECT/CT Camera for Small Animal Imaging at UMMS
    Donald Hnatowich; Fiscal Year: 2007
    ..Modalities such as positron emission tomography (PET) and single photon emission tomography (SPECT) are of considerable value to researchers concerned ..
  77. Therapy for Liver Cancer by Targeting Energy Metabolism
    Jean Francois Geschwind; Fiscal Year: 2007
    ..This property is commonly used clinically in Positron Emission Tomography (PET) to detect cancers and assess their degree of malignancy...