emission computed tomography

Summary

Summary: Tomography using emissions from radionuclides and a computer algorithm to reconstruct the image.

Top Publications

  1. ncbi Time course of tumor metabolic activity during chemoradiotherapy of esophageal squamous cell carcinoma and response to treatment
    Hinrich A Wieder
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaningerstrasse 22, D 81675 Munich, Germany
    J Clin Oncol 22:900-8. 2004
  2. ncbi Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography
    Didier Lardinois
    Divisions of Thoracic Surgery, University Hospital of Zurich, Zurich, Switzerland
    N Engl J Med 348:2500-7. 2003
  3. ncbi Effects of neoadjuvant radio-chemotherapy on 18F-FDG-PET in esophageal carcinoma
    I Brink
    Division of Nuclear Medicine, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Eur J Surg Oncol 30:544-50. 2004
  4. ncbi Focal FDG uptake in mediastinal brown fat mimicking malignancy: a potential pitfall resolved on PET/CT
    Mylene T Truong
    Division of Diagnostic Imaging, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 57, Houston, TX 77030, USA
    AJR Am J Roentgenol 183:1127-32. 2004
  5. ncbi In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:844-50. 2003
  6. ncbi Prognostic importance of the standardized uptake value on (18)F-fluoro-2-deoxy-glucose-positron emission tomography scan in non-small-cell lung cancer: An analysis of 125 cases. Leuven Lung Cancer Group
    J F Vansteenkiste
    Department of Pulmonology, Respiratory Oncology Unit, University Hospital Gasthuisberg, Catholic University, Leuven, Belgium
    J Clin Oncol 17:3201-6. 1999
  7. ncbi Positron emission tomography for assessment of the response to induction radiochemotherapy in locally advanced oesophageal cancer
    P Flamen
    Department of Nuclear Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Ann Oncol 13:361-8. 2002
  8. ncbi Screening for cerebral metastases with FDG PET in patients undergoing whole-body staging of non-central nervous system malignancy
    Eric M Rohren
    Department of Radiology, Duke University Medical Center, Durham, NC, USA
    Radiology 226:181-7. 2003
  9. ncbi Early restaging positron emission tomography with ( 18)F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin's lymphoma
    K Spaepen
    Departments of Nuclear Medicine, University Hospital Gasthuisberg and Catholic University of Leuven, Leuven, Belgium
    Ann Oncol 13:1356-63. 2002
  10. pmc Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002

Research Grants

Detail Information

Publications254 found, 100 shown here

  1. ncbi Time course of tumor metabolic activity during chemoradiotherapy of esophageal squamous cell carcinoma and response to treatment
    Hinrich A Wieder
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaningerstrasse 22, D 81675 Munich, Germany
    J Clin Oncol 22:900-8. 2004
    ....
  2. ncbi Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography
    Didier Lardinois
    Divisions of Thoracic Surgery, University Hospital of Zurich, Zurich, Switzerland
    N Engl J Med 348:2500-7. 2003
    ....
  3. ncbi Effects of neoadjuvant radio-chemotherapy on 18F-FDG-PET in esophageal carcinoma
    I Brink
    Division of Nuclear Medicine, University Hospital Freiburg, Hugstetterstr 55, 79106 Freiburg, Germany
    Eur J Surg Oncol 30:544-50. 2004
    ..To investigate whether results of [F-18]-fluorodeoxy-d-glucose (FDG) positron emission tomography (PET) of esophageal cancer (EC) before and after neoadjuvant radio-chemotherapy correlate with histopathology after esophageal resection...
  4. ncbi Focal FDG uptake in mediastinal brown fat mimicking malignancy: a potential pitfall resolved on PET/CT
    Mylene T Truong
    Division of Diagnostic Imaging, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 57, Houston, TX 77030, USA
    AJR Am J Roentgenol 183:1127-32. 2004
    ..The purpose of this study was to determine the prevalence, location, and appearance of hypermetabolic brown fat in the mediastinum...
  5. ncbi In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:844-50. 2003
    ..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy...
  6. ncbi Prognostic importance of the standardized uptake value on (18)F-fluoro-2-deoxy-glucose-positron emission tomography scan in non-small-cell lung cancer: An analysis of 125 cases. Leuven Lung Cancer Group
    J F Vansteenkiste
    Department of Pulmonology, Respiratory Oncology Unit, University Hospital Gasthuisberg, Catholic University, Leuven, Belgium
    J Clin Oncol 17:3201-6. 1999
    ..The Standardized Uptake Value (SUV), a semi-quantitative measurement of FDG uptake on positron emission tomography (PET) scan, could thus be of prognostic significance...
  7. ncbi Positron emission tomography for assessment of the response to induction radiochemotherapy in locally advanced oesophageal cancer
    P Flamen
    Department of Nuclear Medicine, University Hospital Gasthuisberg, Leuven, Belgium
    Ann Oncol 13:361-8. 2002
    ....
  8. ncbi Screening for cerebral metastases with FDG PET in patients undergoing whole-body staging of non-central nervous system malignancy
    Eric M Rohren
    Department of Radiology, Duke University Medical Center, Durham, NC, USA
    Radiology 226:181-7. 2003
    ....
  9. ncbi Early restaging positron emission tomography with ( 18)F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin's lymphoma
    K Spaepen
    Departments of Nuclear Medicine, University Hospital Gasthuisberg and Catholic University of Leuven, Leuven, Belgium
    Ann Oncol 13:1356-63. 2002
    ..This study was intended to assess the value of a midtreatment fluorine-18 fluorodeoxyglucose positron emission tomography ([(18)F]FDG-PET) scan to predict clinical outcome in patients with aggressive NHL...
  10. pmc Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002
    ..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease...
  11. ncbi Imaging gliomas with positron emission tomography and single-photon emission computed tomography
    Francois Benard
    Department of Nuclear Medicine and Radiation Biology, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Semin Nucl Med 33:148-62. 2003
    ..with gliomas, particularly with high-grade lesions, the overall clinical utility of single photon emission computed tomography (SPECT) and PET in characterizing recurrent lesions remains dependent on the availability of effective ..
  12. ncbi Blood flow and metabolism in locally advanced breast cancer: relationship to response to therapy
    David A Mankoff
    Division of Nuclear Medicine, Box 346113, University of Washington, 1959 E Pacific Street, Seattle, WA 98195, USA
    J Nucl Med 43:500-9. 2002
    ....
  13. ncbi Radiation-induced esophagitis on FDG PET imaging
    Peeyush Bhargava
    Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Nucl Med 28:849-50. 2003
  14. ncbi Patterns of (18)F-FDG uptake in adipose tissue and muscle: a potential source of false-positives for PET
    Henry W D Yeung
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Nucl Med 44:1789-96. 2003
    ..The goal of this study was to characterize this normal variant of (18)F-FDG uptake in terms of incidence and characteristic extent...
  15. ncbi 2-Fluoro-2-deoxy-D-glucose positron emission tomography imaging is predictive of pathologic response and survival after preoperative chemoradiation in patients with esophageal carcinoma
    Stephen G Swisher
    Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 101:1776-85. 2004
    ..Preliminary reports suggest that FDG-PET may be predictive of the response of esophageal carcinoma patients to preoperative CRT...
  16. ncbi Diagnostic and prognostic value of [(18)F]fluorodeoxyglucose positron emission tomography for recurrent head and neck squamous cell carcinoma
    R J Wong
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 20:4199-208. 2002
    ..We evaluated the diagnostic accuracy and prognostic value of [(18)F]fluorodeoxyglucose positron emission tomography (PET) in this patient population...
  17. ncbi Diagnostic value of MRI in comparison to scintigraphy, PET, MS-CT and PET/CT for the detection of metastases of bone
    N Ghanem
    Radiologische Klinik, Abt Röntgendiagnostik, Universitatsklinikum Freiburg, Albert Ludwigs Universitat Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Eur J Radiol 55:41-55. 2005
    ..Larger, prospective multicenter studies are necessary to establish these as new, promising methods for the detection of osteal metastases...
  18. ncbi Effect of corrections for blood glucose and body size on [18F]FDG PET standardised uptake values in lung cancer
    W A Hallett
    The Clinical PET Centre, Guy s, King s and St Thomas School of Medicine, St Thomas Hospital, London, UK
    Eur J Nucl Med 28:919-22. 2001
    ..The strong correlation between SUV(BG) and blood glucose concentration suggests that for non-diabetic fasted patients, lung tumour SUVs should not be adjusted for blood glucose...
  19. ncbi Clinical applications of PET in oncology
    Eric M Rohren
    Department of Radiology, Duke University Medical Center, Rm 1410, Duke North, Erwin Rd, Durham, NC 27710, USA
    Radiology 231:305-32. 2004
    ..Other applications are being used clinically but have not been as carefully evaluated in the literature, and these applications may not be covered by third-party payers. The developing applications of PET are included in this review...
  20. ncbi Prognostic value of [18F]FDG-PET imaging in small cell lung cancer
    Neeta Pandit
    Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Eur J Nucl Med Mol Imaging 30:78-84. 2003
    ..We conclude that FDG-PET imaging provides prognostic information in treated patients. A positive study and a high SUV(max) are significantly associated with poor survival. Additionally, FDG-PET may be helpful in staging and follow-up...
  21. ncbi Electromechanical mapping for determination of myocardial contractility and viability. A comparison with echocardiography, myocardial single-photon emission computed tomography, and positron emission tomography
    Andreas Keck
    St Georg Hospital, Hamburg, Germany
    J Am Coll Cardiol 40:1067-74; discussion 1075-8. 2002
    ..The purpose of this study was to validate electromechanical viability parameters with combined myocardial perfusion and metabolic imaging and echocardiography...
  22. ncbi 18-FDG PET scan in the staging of recurrent melanoma: additional value and therapeutic impact
    M Stas
    Department of Surgical Oncology, University Hospitals, Catholic University Leuven, Belgium
    Melanoma Res 12:479-90. 2002
    ....
  23. ncbi Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT): Clinical Applications
    Pamela Blake
    Department of Neurology, Center for the Study of Learning, Georgetown University Medical Center, Washington, USA
    J Neuroophthalmol 23:34-41. 2003
    Positron emission tomography and single-photon emission computed tomography are nuclear imaging modalities that excel in depicting the biological function of tissue...
  24. ncbi Electromechanical mapping versus positron emission tomography and single photon emission computed tomography for the detection of myocardial viability in patients with ischemic cardiomyopathy
    Henrik Wiggers
    Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark
    J Am Coll Cardiol 41:843-8. 2003
    ..system, Biosense-Webster, Haifa, Israel) with positron emission tomography (PET) and single photon emission computed tomography (SPECT) for prediction of reversibly dysfunctional myocardium (RDM) and irreversibly dysfunctional ..
  25. ncbi Adrenal lesions: characterization with fused PET/CT image in patients with proved or suspected malignancy--initial experience
    Michael A Blake
    Division of Abdominal and Interventional Radiology, Massachusetts General Hospital, Boston, 02114, USA
    Radiology 238:970-7. 2006
    ..To retrospectively evaluate the accuracy of the fused positron emission tomographic (PET)/computed tomographic (CT) image for characterization of adrenal lesions in patients who have proved malignancy or are suspected of having malignancy...
  26. ncbi Technetium 99m ethylcysteinate dimer single-photon emission computed tomography (SPECT) during intellectual stress test in children and adolescents with pure versus comorbid attention-deficit hyperactivity disorder (ADHD)
    Mordechai Lorberboym
    Department of Nuclear Medicine, Edith Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Child Neurol 19:91-6. 2004
    ..girls with comorbid ADHD (group 2: mean age 11 years, range 8-16 years) were studied by single-photon emission computed tomography (SPECT). The patients were not receiving any medication for at least 48 hours prior to the study...
  27. ncbi Detection of misery perfusion with split-dose 123I-iodoamphetamine single-photon emission computed tomography in patients with carotid occlusive diseases
    Masao Imaizumi
    Division of Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Stroke 33:2217-23. 2002
    ..In clinical practice, the detection of patients with misery perfusion through the use of widely available, noninvasive, and cost-effective modalities such as single-photon emission computed tomography (SPECT) is extremely important.
  28. ncbi Value of F-18 fluorodeoxyglucose positron emission tomography for predicting the clinical outcome of patients with aggressive lymphoma prior to and after autologous stem-cell transplantation
    Jean Emmanuel Filmont
    Ahmanson Biological Imaging Clinic, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Chest 124:608-13. 2003
    ....
  29. ncbi Iterative reconstruction techniques in emission computed tomography
    Jinyi Qi
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Phys Med Biol 51:R541-78. 2006
    ..Here we review recent progress in developing statistically based iterative techniques for emission computed tomography. We describe the different formulations of the emission image reconstruction problem and their ..
  30. ncbi Incidental colonic fluorodeoxyglucose uptake: correlation with colonoscopic and histopathologic findings
    Rozet Tatlidil
    PET Imaging Science Center, Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, 2250 Alcazar St, Suite 101, Los Angeles 90033 4609, USA
    Radiology 224:783-7. 2002
    ....
  31. ncbi Predictive impact of 2-18fluoro-2-deoxy-D-glucose positron emission tomography for residual postchemotherapy masses in patients with bulky seminoma
    M De Santis
    Department of Medical Oncology and Luwdig Boltzmann Institute for Applied Cancer Research, Kaiser Franz Josef Spital, Wien, Austria
    J Clin Oncol 19:3740-4. 2001
    ..CONCLUSION: FDG PET is a clinically useful predictor of viable tumor in postchemotherapy residuals of pure seminoma, especially those greater than 3 cm...
  32. ncbi 18fluorodeoxyglucose positron emission tomography to detect mediastinal or internal mammary metastases in breast cancer
    W B Eubank
    Department of Radiology, University of Washington School of Medicine, Seattle, USA
    J Clin Oncol 19:3516-23. 2001
    ....
  33. ncbi Pharmacokinetic evaluation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography
    A Saleem
    Cancer Research Campaign Positron Emission Tomography Oncology Group, Division of Cancer Medicine, Imperial College School of Medicine, Medical Research Council Cyclotron Unit, Hammersmith Hospital, UK
    J Clin Oncol 19:1421-9. 2001
    ..In the presence of unlabeled DACA, pharmacokinetics were altered in myocardium, spleen, and tumors. These data have implications for predicting activity and toxicity of DACA and support the use of PET early in drug development...
  34. ncbi Impact of FDG-PET on radiation therapy volume delineation in non-small-cell lung cancer
    Jeffrey Bradley
    Department of Radiation Oncology, Mallinkrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 59:78-86. 2004
    ....
  35. ncbi FDG-PET for clinical use. Results of the 3rd German Interdisciplinary Consensus Conference, "Onko-PET III", 21 July and 19 September 2000
    S N Reske
    Department of Nuclear Medicine, University Clinic of Ulm, Robert Koch Strasse 8, 89070 Ulm, Germany
    Eur J Nucl Med 28:1707-23. 2001
    ..There are clear-cut clinical indications for FDG-PET in diagnosis, staging and therapy control, and the technique can help to improve the management of many patients with cancer...
  36. ncbi PET imaging in breast cancer
    E Bombardieri
    PET Unit, Division of Nuclear Medicine, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Q J Nucl Med 45:245-56. 2001
    ..These statements are coming from the examination of more than 2000 breast cancer patients included in 88 articles or abstracts on studies in which FDG-PET was used for breast cancer detection...
  37. ncbi Early estimation of acute myocardial infarct size soon after coronary reperfusion using emission computed tomography with technetium-99m pyrophosphate
    T Hashimoto
    Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan
    Am J Cardiol 60:952-7. 1987
    ..Early technetium-99m pyrophosphate imaging was performed by emission computed tomography to evaluate reperfusion and to test the feasibility of estimating infarct size soon after coronary ..
  38. ncbi Design and construction of a realistic digital brain phantom
    D L Collins
    Montreal Neurological Institute, McGill University, McConnell Brain Imaging Centre, Canada
    IEEE Trans Med Imaging 17:463-8. 1998
    ..The brain phantom and simulated MR images have been made publicly available on the Internet (http://www.bic.mni.mcgill.ca/brainweb)...
  39. ncbi Positron emission imaging of head and neck cancer, including thyroid carcinoma
    Heiko Schoder
    Department of Radiology Nuclear Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Semin Nucl Med 34:180-97. 2004
    ..Although diffuse FDG uptake usually indicates thyroiditis, focal uptake has been related to thyroid cancer in 25-50% of cases and should therefore be evaluated further if a proven malignancy would cause a change in patient management...
  40. ncbi Is 18F-FDG PET more accurate than standard diagnostic procedures in the detection of suspected recurrent melanoma?
    David Fuster
    Nuclear Medicine Division, Radiology Department, University of Pennsylvania, Philadelphia 19104, USA
    J Nucl Med 45:1323-7. 2004
    ..The aim of this study was to determine the accuracy of (18)F-FDG PET in detecting recurrent melanoma...
  41. ncbi Colorectal cancer screening in asymptomatic adults: the role of FDG PET scan
    Yen Kung Chen
    Department of Nuclear Medicine, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Anticancer Res 23:4357-61. 2003
    ..FDG PET could detect large size (> 0.7 cm) and pre-malignant change of colonic adenoma. It is possible to differentiate adenoma from carcinoma of colon by an increased rate of glycolysis (SUV) in carcinoma...
  42. ncbi The impact of FDG PET on the management of occult primary head and neck tumours
    W L Wong
    The Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex, UK
    Clin Oncol (R Coll Radiol) 15:461-6. 2003
    ..The aim of this study was to investigate the impact of positron-emission tomography (PET) with 18F-labelled fluoro-2-deoxy-D-glucose (FDG) in the management of occult primary head and neck tumours...
  43. ncbi Combined functional and structural evaluation of cancer patients with a hybrid camera-based PET/CT system using (18)F-FDG
    Ora Israel
    Department of Nuclear Medicine, Rambam Medical Center, Haifa, Israel
    J Nucl Med 43:1129-36. 2002
    ..The value of hybrid imaging using a gamma camera-based PET/CT and (18)F-FDG in determining the relationship between mass and cancer was assessed...
  44. ncbi Impact of FDG PET on defining the extent of disease and on the treatment of patients with recurrent or metastatic breast cancer
    William B Eubank
    Department of Radiology, Puget Sound Veterans Affairs Health Care System, 1660 S Columbian Way, S 113 RAD, Seattle, WA 98108, USA
    AJR Am J Roentgenol 183:479-86. 2004
    ..Our aim was to evaluate the impact of FDG PET on defining the extent of disease and on the treatment of patients with advanced breast cancer...
  45. ncbi 18-fluoro-2-deoxyglucose positron emission tomography in detecting residual/recurrent nasopharyngeal carcinomas and comparison with magnetic resonance imaging
    Ruoh Fang Yen
    Department of Nuclear Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Cancer 98:283-7. 2003
    ..To compare FDG-PET with the conventional magnetic resonance imaging (MRI) for the detection of residual/recurrent NPC, the authors studied 67 follow-up cases of patients with NPC using both FDG-PET and MRI...
  46. pmc Imaging transgene expression with radionuclide imaging technologies
    S S Gambhir
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095 1770, USA
    Neoplasia 2:118-38. 2000
    ..Radionuclide approaches using single photon emission computed tomography (SPECT) and positron emission tomography (PET) are the most mature of the current imaging technologies ..
  47. pmc Whole body PET/CT imaging for detection of metastatic choroidal melanoma
    P T Finger
    Br J Ophthalmol 88:1095-7. 2004
  48. ncbi Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology
    Gerald Antoch
    Department of Diagnostic, University Hospital Essen, Essen, Germany
    JAMA 290:3199-206. 2003
    ..Magnetic resonance imaging (MRI) and a combined modality including positron emission tomography (PET) and computed tomography (CT) provide whole-body tumor staging in a single session...
  49. ncbi Uptake in supraclavicular area fat ("USA-Fat"): description on 18F-FDG PET/CT
    Christian Cohade
    Division of Nuclear Medicine, The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 44:170-6. 2003
    ..PET/CT offers the unique opportunity to correlate PET findings with CT anatomy in the supraclavicular region...
  50. ncbi Impact of positron emission tomography on the management of patients with small-cell lung cancer: preliminary experience
    Robert Blum
    Division of Haematology and Medical Oncology, Peter MacCallum Cancer Institute, East Melbourne, Vic, Australia
    Am J Clin Oncol 27:164-71. 2004
    ..PET-CR conferred longer median time to progression (13.7 months) than no CR (9.7 months). FDG-PET for SCLC was often discordant with conventional assessment and frequently influenced management...
  51. ncbi F-18 fluorodeoxyglucose positron-emission tomography in the diagnosis of tumor recurrence and metastases in the follow-up of patients with breast carcinoma: a comparison to conventional imaging
    Hans Jürgen Gallowitsch
    Department of Nuclear Medicine and Endocrinology, PET Center, State Hospital Klagenfurt, Austria
    Invest Radiol 38:250-6. 2003
    ....
  52. ncbi Ratio-images calculated from interictal positron emission tomography and single-photon emission computed tomography for quantification of the uncoupling of brain metabolism and perfusion in epilepsy
    I G Zubal
    Department of Diagnostic Imaging, Yale University School of Medicine, New Haven, Connecticut, USA
    Epilepsia 41:1560-6. 2000
    ..processing techniques were applied to interictal positron emission tomography (PET) and single-photon emission computed tomography (SPECT) brain images to aid in the localization of epileptogenic foci by calculating a functional image ..
  53. ncbi Prospective multicenter study of axillary nodal staging by positron emission tomography in breast cancer: a report of the staging breast cancer with PET Study Group
    Richard L Wahl
    Division of Nuclear Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Clin Oncol 22:277-85. 2004
    ..To determine the accuracy of positron emission tomography with fluorine-18-labeled 2-fluoro-2-deoxy-d-glucose (FDG-PET) in detecting axillary nodal metastases in women with primary breast cancer...
  54. ncbi Inefficacy of F-18 fluorodeoxy-D-glucose-positron emission tomography scans for initial evaluation in early-stage cutaneous melanoma
    Jeffrey D Wagner
    Department of Surgery, Indiana University School of Medicine, Indiana University Purdue University at Indianapolis, Suite 570 Clearvista Parkway, Indianapolis, IN 46556, USA
    Cancer 104:570-9. 2005
    ....
  55. ncbi Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography
    Reinhard Bos
    Department of Pathology, Positron Emission Tomography Research Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 20:379-87. 2002
    ..At present, no satisfactory biologic explanation exists for this phenomenon. This study compared (18)FDG uptake in vivo with biomarkers expected to be involved in the underlying biologic mechanisms...
  56. ncbi Comparison of imaging with FDG PET/CT with other imaging modalities in myeloma
    Richard J Breyer
    Department of Radiology, University of Maryland Medical Center, 22 South Greene St, Baltimore, MD 21201, USA
    Skeletal Radiol 35:632-40. 2006
    ..To determine the usefulness of FDG PET/CT scanning in the management and staging of myeloma and to assess its strengths and limitations...
  57. pmc Positron emission tomography provides molecular imaging of biological processes
    M E Phelps
    Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, University of California Los Angeles School of Medicine, Box 951735, Los Angeles, CA 90095 1735, USA
    Proc Natl Acad Sci U S A 97:9226-33. 2000
    ....
  58. ncbi Impact of metallic dental implants on CT-based attenuation correction in a combined PET/CT scanner
    EhabI M Kamel
    Division of Nuclear Medicine, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
    Eur Radiol 13:724-8. 2003
    ..This may falsely estimate PET quantitative studies and may disturb the visual interpretation of PET scan...
  59. ncbi Direct comparison of (18)F-FDG PET and PET/CT in patients with colorectal carcinoma
    Christian Cohade
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Nucl Med 44:1797-803. 2003
    ..The purpose of this study was to compare (18)F-FDG PET and PET/CT in a population of patients with colorectal cancer...
  60. ncbi PET diagnostic accuracy: improvement with in-line PET-CT system: initial results
    Thomas F Hany
    Department of Medical Radiology, Division of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Radiology 225:575-81. 2002
    ..Stepwise analysis of coregistered images revealed a significant (P <.05, McNemar test) improvement in lesion classification between PET images alone and coregistered images from the PET-CT examination...
  61. ncbi Follow-up of women with breast cancer: comparison between MRI and FDG PET
    Gerhard W Goerres
    Division of Nuclear Medicine, University Hospital, Raemistrasse 100, 8091 Zurich, Switzerland
    Eur Radiol 13:1635-44. 2003
    ..In this study both imaging methods had comparable accuracy. The detection of distant metastases with whole-body PET imaging can influence patient management...
  62. ncbi Comparison of FDG-PET and technetium-99m MIBI SPECT to detect metastatic cervical lymph nodes in well-differentiated thyroid carcinoma with elevated serum HTG but negative I-131 whole body scan
    Hurng Sheng Wu
    Department of Surgery, Show Chwan Memorial Hospital, Changhua, Taiwan
    Anticancer Res 23:4235-8. 2003
    ..emission tomography (PET) and technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) single photon emission computed tomography (SPECT) in detecting metastatic cervical lymph nodes (LN) in well-differentiated thyroid carcinoma (DTC)..
  63. ncbi Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions
    G J Cook
    Clinical Positron Emission Tomography Centre and Department of Oncology, Guys Hospital, United Medical and Dental Schools, London, United Kingdom
    J Clin Oncol 16:3375-9. 1998
    ..We have compared 18FDG PET with 99mTc MDP bone scintigraphy in patients with skeletal metastases from breast cancer and have analyzed the data in subgroups based on radiographic characteristics of lesions...
  64. ncbi [18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors
    Dietlind Sorger
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Nucl Med Biol 30:317-26. 2003
    ..This advantage of a faster reduction of unspecific binding, in light of similar or marginally lower tumor uptake, warrants further investigation of (18)FAZA as a marker of regional hypoxia in tumors...
  65. ncbi (90)Y bremsstrahlung emission computed tomography using gamma cameras
    Shigeki Ito
    Radioisotope Research Center, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Ann Nucl Med 23:257-67. 2009
    This study demonstrates images obtained by (90)Y bremsstrahlung emission computed tomography (BECT), and characterizes the system performance of gamma cameras.
  66. ncbi Positron emission tomography and single-photon emission computed tomography brain imaging in the evaluation of dementia
    Ronald L van Heertum
    Department of Radiology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Semin Nucl Med 33:77-85. 2003
    ..In the future, neuroreceptor and plaque burden imaging studies should further enhance the sensitivity and specificity of dementia detection and patient management...
  67. ncbi Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation
    Karoline Spaepen
    Department of Nuclear Medicine, University Hospital Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Blood 102:53-9. 2003
    ..000001) and OS (P <.00002). [18F]FDG-PET has an important prognostic role in the pretransplantation evaluation of patients with lymphoma and enlarges the concept of chemosensitivity used to select patients for HDT/SCT...
  68. ncbi Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin
    Roy S Herbst
    Department of Thoracic and Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 20:3804-14. 2002
    ..We present the initial results of a dose-finding clinical trial of recombinant human endostatin (rh-Endo) that examined potential surrogates for response to antiangiogenic therapy...
  69. ncbi The development of [(124)I]iodinated-VG76e: a novel tracer for imaging vascular endothelial growth factor in vivo using positron emission tomography
    David R Collingridge
    Cancer Research UK Positron Emission Tomography Oncology Group, Department of Cancer Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London W12 0NN
    Cancer Res 62:5912-9. 2002
    ..These studies support further development of [(124)I]-SHPP-VG76e as a radiotracer for measuring tumor levels of VEGF in humans...
  70. ncbi Iodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography
    Matthias Glaser
    Imaging Research Solutions Ltd, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Appl Radiat Isot 58:55-62. 2003
    ..A significantly higher (21%) binding in treated cells was observed with [125I]m-SIB-annexin-V. The binding of [125I]m-SIB labelled annexin-V to camptothecin treated cells was blocked (68%) by a 100-fold excess of unlabelled annexin-V...
  71. ncbi Positron emission tomography for staging esophageal cancer: does it lead to a different therapeutic approach?
    Werner Kneist
    Department of General and Visceral Surgery, Hospital of the Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    World J Surg 27:1105-12. 2003
    ....
  72. ncbi Increased uptake of the apoptosis-imaging agent (99m)Tc recombinant human Annexin V in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis
    Tarik Belhocine
    Division of Nuclear Medicine, University Hospital of Liege, 4000 Liege, Belgium
    Clin Cancer Res 8:2766-74. 2002
    ..We evaluated in a Phase I study the safety and the feasibility of (99m)Tc-Annexin V for imaging chemotherapy-induced apoptosis in human cancers immediately after the first course of chemotherapy...
  73. ncbi Prediction of response to preoperative chemotherapy in adenocarcinomas of the esophagogastric junction by metabolic imaging
    W A Weber
    Departments of Nuclear Medicine, Surgery, Pathology, Radiology, and Medical Statistics, Technische Universitat Munchen, Munchen, Germany
    J Clin Oncol 19:3058-65. 2001
    ..This study evaluates whether positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (FDG) may predict response early in the course of therapy...
  74. ncbi PET studies in dementia
    Karl Herholz
    Neurologische Universitatsklinik, Max Planck Institut für neurologische Forschung, Koln, Germany
    Ann Nucl Med 17:79-89. 2003
    ..In LBD there is also impairment of dopamine synthesis, similar to Parkinson disease...
  75. ncbi Test performance of positron emission tomography and computed tomography for mediastinal staging in patients with non-small-cell lung cancer: a meta-analysis
    Michael K Gould
    Pulmonary Section 111P, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    Ann Intern Med 139:879-92. 2003
    ....
  76. ncbi Normal patterns and variants in single-photon emission computed tomography and positron emission tomography brain imaging
    Andrew B Newberg
    Division of Nuclear Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Semin Nucl Med 33:42-55. 2003
    ....
  77. ncbi Positron emission tomography and single photon emission computed tomography in epilepsy care
    Thomas R Henry
    Emory Epilepsy Center, Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Semin Nucl Med 33:88-104. 2003
    ..planning in epilepsy, the functional imaging modalities currently established are ictal single photon emission computed tomography (SPECT) with [(99m)Tc]technetium-hexamethylpropyleneamine oxime (HMPAO) or with [(99m)Tc]technetium-..
  78. ncbi Positron emission tomography and single-photon emission computed tomography in substance abuse research
    Nora D Volkow
    Brookhaven National Laboratory, Upton, NY 11973, USA
    Semin Nucl Med 33:114-28. 2003
    ..advances in radiotracer design and chemistry and positron emission tomography (PET) and single-photon emission computed tomography (SPECT) instrumentation and the integration of these scientific tools with the tools of biochemistry, ..
  79. ncbi Noninvasive imaging of tumor hypoxia in rats using the 2-nitroimidazole 18F-EF5
    L S Ziemer
    University of Pennsylvania School of Veterinary Medicine, Section of Radiology, 3850 Spruce Street, Philadelphia, PA 19104, USA
    Eur J Nucl Med Mol Imaging 30:259-66. 2003
    ..Plans are underway to initiate a research project to determine the safety and preliminary evidence for the efficacy of this preparation in patients with brain tumors...
  80. ncbi 3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography
    Henryk Barthel
    Cancer Research United Kingdom PET Oncology Group, Department of Cancer Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital Campus, London W12 0NN, United Kingdom
    Cancer Res 63:3791-8. 2003
    ..The decrease in [(18)F]FLT uptake after 5-FU was more pronounced than that of [(18)F]FDG. [(18)F]FLT is, therefore, a promising marker for monitoring antiproliferative drug activity in oncology that warrants additional testing...
  81. ncbi Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management
    Rachel Bar-Shalom
    Department of Nuclear Medicine, Rambam Medical Center, Haifa 35254, Israel
    J Nucl Med 44:1200-9. 2003
    ..This study assessed the clinical performance of a combined PET/CT system using (18)F-FDG in oncologic patients...
  82. ncbi Comparing 18-fluoro-2-deoxyglucose positron emission tomography with a combination of technetium 99m tetrofosmin single photon emission computed tomography and computed tomography to detect recurrent or persistent nasopharyngeal carcinomas after radiother
    C H Kao
    Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    Cancer 92:434-9. 2001
    ..accuracy of combined computed tomography (CT) and technetium 99m tetrofosmin (Tc-TF) single photon emission computed tomography (SPECT) of head and neck to differentiate recurrent or residual nasopharyngeal carcinomas (NPCs) from ..
  83. ncbi Selective arterial distribution of cerebral hyperperfusion in Fabry disease
    D F Moore
    Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10 Room 3D03, 9000 Rockville Pike, Bethesda, MD 20892-1260, USA
    J Neuroimaging 11:303-7. 2001
    ..The data demonstrated that the posterior circulation is the predominant arterial territory with a significantly increased rCBF in Fabry disease. No arterial distribution had a decreased rCBF...
  84. ncbi Evaluation of 18F-FDG PET in patients with advanced, metastatic, or recurrent gastric cancer
    Takashi Yoshioka
    Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Nucl Med 44:690-9. 2003
    ..The aim of this study was to evaluate the visual diagnostic accuracy of (18)F-FDG PET for advanced, metastatic, or recurrent gastric cancer and to generate semiquantitative values for lesions...
  85. ncbi Prognostic value of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose ([18F]FDG) after first-line chemotherapy in non-Hodgkin's lymphoma: is [18F]FDG-PET a valid alternative to conventional diagnostic methods?
    K Spaepen
    Department of Nuclear Medicine, University Hospital Gasthuisberg and Catholic University of Leuven, Leuven, Belgium
    J Clin Oncol 19:414-9. 2001
    ..In this study, we evaluated the value of PET in detecting residual disease and, hence, predicting relapse after first-line treatment in patients with non-Hodgkin's lymphoma (NHL)...
  86. ncbi A head motion measurement system suitable for emission computed tomography
    S R Goldstein
    Biomedical Engineering and Instrumentation Program, National Institutes of Health, Bethesda, MD 20892, USA
    IEEE Trans Med Imaging 16:17-27. 1997
    ..6 degree for all rotations...
  87. ncbi Breast imaging with positron emission tomography and fluorine-18 fluorodeoxyglucose: use and limitations
    N Avril
    Departments of Nuclear Medicine and Gynecology, Technische Universitat Munchen, Munich, Germany
    J Clin Oncol 18:3495-502. 2000
    ..To evaluate the diagnostic value of positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (FDG) for the diagnosis of primary breast cancer...
  88. ncbi Prognostic value of positron emission tomography in the evaluation of post-treatment residual mass in patients with Hodgkin's disease and non-Hodgkin's lymphoma
    R Naumann
    Department of Internal Medicine I, University Hospital Carl Gustav Carus at the Dresden University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    Br J Haematol 115:793-800. 2001
    ..In conclusion, FDG-PET is a suitable non-invasive method with a high degree of accuracy in the prediction of early recurrence in lymphoma patients with CRu...
  89. ncbi 18FDG-PET following treatment as valid predictor for disease-free survival in Hodgkin's lymphoma
    M de Wit
    Department of Oncology and Hematology, University Hospital Eppendorf, Hamburg, Germany
    Ann Oncol 12:29-37. 2001
    ..The value of 18FDG-PET to predict the outcome after therapy in Hodgkin's lymphoma was compared to morphologic staging and ESR...
  90. pmc Fluorodeoxyglucose positron emission tomography in the evaluation of germ cell tumours at relapse
    S F Hain
    The Clinical PET Centre, London, UK
    Br J Cancer 83:863-9. 2000
    ..FDG-PET effected a management change in 57% of cases. FDG-PET scanning detected viable tumour in residual masses and identified sites of disease in suspected recurrence...
  91. ncbi Whole body 18FDG-PET and the response of esophageal cancer to induction therapy: results of a prospective trial
    Robert J Downey
    Thoracic Service and Gastric and Mixed Tumor Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 21:428-32. 2003
    ....
  92. ncbi Whole-body positron emission tomography using 18F-fluorodeoxyglucose compared to standard procedures for staging patients with Hodgkin's disease
    G Jerusalem
    Medical Oncology, CHU Sart Tilman, B35 B 4000, Li ge 1, Belgium
    Haematologica 86:266-73. 2001
    ..In the present study we evaluated the role of (18)F-FDG PET compared to routine procedures for the staging of patients with HD...
  93. ncbi Single photon emission computed tomography imaging in obsessive-compulsive disorder and for stereotactic bilateral anterior cingulotomy
    Jin Woo Chang
    BK21 Project for Medical Science, Yonsei University College of Medicine, Yonsei University College of Medicine, Seoul, Korea
    Neurosurg Clin N Am 14:237-50. 2003
    ..Furthermore, our operative technique of anterior cingulotomy, featuring a larger lesion, seems to be effective in ameliorating the symptoms of OCD without causing any serious complications...
  94. ncbi Usefulness of positron emission tomography for assessing the response of neoadjuvant chemoradiotherapy in patients with esophageal cancer
    Hiroyuki Kato
    Department of Surgery I, Gunma University Faculty of Medicine, 3 39 22, Showa machi, Maebashi 371 8511, Japan
    Am J Surg 184:279-83. 2002
    ....
  95. pmc FDG-PET in the prediction of survival of patients with cancer of the pancreas: a pilot study
    N R Maisey
    Department of Medicine, Nuclear Medicine and Academic, The Royal Marsden NHS Trust, Sutton, Surrey, UK
    Br J Cancer 83:287-93. 2000
    ..Larger prospective studies are required to confirm this finding...
  96. ncbi Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer: the PLUS multicentre randomised trial
    Harm Van Tinteren
    Comprehensive Cancer Centre Amsterdam, Amsterdam, Netherlands
    Lancet 359:1388-93. 2002
    ..We did a randomised controlled trial in patients with suspected non-small-cell lung cancer, who were scheduled for surgery after conventional workup, to test whether PET with 18FDG reduces number of futile thoracotomies...
  97. pmc Neoadjuvant therapy of esophageal squamous cell carcinoma: response evaluation by positron emission tomography
    B L Brücher
    Chirurgische Klinik und Poliklinik, Klinikum Rechts der Isar der Technischen Universitat, Munich, Germany
    Ann Surg 233:300-9. 2001
    ..To evaluate the use of positron emission tomography using [(18)F]-fluorodeoxyglucose (FDG-PET) to assess the response to neoadjuvant radiotherapy and chemotherapy in patients with locally advanced esophageal cancer...
  98. ncbi Whole-body PET with FDG for the diagnosis of recurrent gastric cancer
    T De Potter
    Department of Nuclear Medicine, University Hospital Leuven KU Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Nucl Med Mol Imaging 29:525-9. 2002
    ..However, FDG-PET appears to provide important additional information concerning the prognosis of recurrent gastric cancer...
  99. ncbi [2002 Standards, Options and Recommendations for the use of [18F]-FDG (PET-FDG) in cancerology]
    Patrick Bourguet
    Bull Cancer 90:S1-109. 2003
  100. ncbi Assessment of the technology for functional imaging in cancer
    G R Laking
    CRC PET Oncology Group, MRC Cyclotron Building, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Eur J Cancer 38:2194-9. 2002
    ..Cancer clinicians need to take an increased role in functional imaging research, as they have primary expertise in the development and use of treatments modifying cell and tissue function...
  101. ncbi Prognostic significance of 18F-fluorodeoxyglucose positron emission tomography in lymphoma
    Martin R Weihrauch
    Department of Internal Medicine I, University of Cologne, Cologne, Germany
    Leuk Lymphoma 44:15-22. 2003
    ..To assess the prognostic implications of PET in the post-therapeutic setting, we performed a MedLine Search and reviewed the current available studies on this important issue together with our own data...

Research Grants74

  1. Phage Display for Improved Peptide-based Tumor Targeting and Imaging Agents
    Susan L Deutscher; Fiscal Year: 2013
    ..loops of polypeptide scaffolds once radiolabeled, will form the foundation for novel single photon emission computed tomography (SPECT) and positron emission computed tomography (PET) imaging agents for prostate, breast, and ..
  2. NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
    Vijay Sharma; Fiscal Year: 2013
    ..Currently, common single-photon emission computed tomography (SPECT) MPI agents comprise 201Tl or moderately hydrophobic and cationic 99mTc-complexes, such as 99mTc-..
  3. Novel Diagnostics to Detect Lung Injury
    Elizabeth R Jacobs; Fiscal Year: 2013
    ..The first is single photon emission computed tomography/computed tomography (SPECT/CT) imaging, using 99m Tc-duramycin (DU) and 99m Tc- ..
  4. PSMA-based Cancer Imaging Agents
    Martin G Pomper; Fiscal Year: 2013
    ..such as magnetic resonance spectroscopy (MRS), positron emission tomography (PET) and single photon emission computed tomography (SPECT) are gaining favor over the anatomic techniques of computed tomography (CT) and MR, which merely ..
  5. Hyperpolarized 129-Xenon-based MRI Probes for Brain Injury
    JEREMY PHILLIP CELVER; Fiscal Year: 2010
    ..The sensitivity of positron emission tomography (PET) and single photon emission computed tomography (SPECT) have led to the widespread use of these technologies for imaging specific bio-molecules in vivo...
  6. DEVELOPMENT OF PET RADIOPHARMACEUTICALS TARGETING GRPR
    Buck E Rogers; Fiscal Year: 2012
    ..that binds with high affinity to GRPR and radiolabeled BN analogs have been evaluated for single photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging of GRPR-expressing cancers...
  7. Novel Receptor-Targeting Theranostic Peptides for Prostate Cancer
    Yubin Miao; Fiscal Year: 2013
    ..Current ProstaScint(R) SPECT (single photon emission computed tomography) and [18F] FDG (2-[18F] fluoro-2-deoxy-D-glucose) PET (positron emission tomography) imaging have ..
  8. Imaging Inflammation in Asthma
    Serpil C Erzurum; Fiscal Year: 2010
    ..the radiopharmaceutical 99mTc-HMPAO (Technetium99m-hexamethylpropylene amine oxime) and single photon emission computed tomography (SPECT), will identify and localize regions of inflammation in asthmatic lungs...
  9. 9 Intl Symposium - Functional Neuroreceptor Mapping of the Living Brain NRM 2012
    DEAN FOSTER WONG; Fiscal Year: 2011
    ..of non-invasive imaging techniques, such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), and other molecular imaging methods to functionally characterize and quantify ..
  10. Alpha Methyl AcylCoa Racemase (AMACR)
    Martin G Pomper; Fiscal Year: 2010
    ..such as magnetic resonance spectroscopy (MRS), positron emission tomography (PET) and single photon emission computed tomography (SPECT) are gaining favor over the anatomic techniques of computed tomography (CT) and MR, which merely ..
  11. Treatment of glucocorticoid-induced osteonecrosis with nano-fullerenes
    Quanjun Cui; Fiscal Year: 2013
    ..real-time PCR, western blot, flow cytometry, blood biochemistry, femur histopathology and single photon emission computed tomography (SPECT) will be employed...
  12. Single Scan Rest/Stress Cardiac PET Imaging
    Arkadiusz Sitek; Fiscal Year: 2012
    ..Current approaches to rest/stress myocardial perfusion imaging with either PET or Single-Photon Emission Computed Tomography (SPECT) require separate imaging at rest and under pharmacologic- or exercise-induced cardiac stress...
  13. PROTEINS IN MULTIPLE MYELOMA AND RELATED BLOOD DISORDERS
    Alan Solomon; Fiscal Year: 2011
    ..radioimaging technology to a) visualize and document the extent of amyloid deposition by single photon emission computed tomography (SPECT) and/or positron emission tomography/computed tomography (PET/CT) using radiolabeled anti-fibril ..
  14. Brain Imaging of Sex Differences in Tobacco Smokers
    Kelly P Cosgrove; Fiscal Year: 2010
    ..The primary focus of the proposed studies is training in neuroreceptor imaging using single photon emission computed tomography (SPECT) and positron emission tomography (PET) modalities to determine the influence of sex, sex ..
  15. Innovative Biomarkers to Predict Radiation Lung Injury
    MEETHA M MEDHORA; Fiscal Year: 2013
    ..Aim 2 will focus on another area of interest of the RFA, organ-specific imaging. Using single-photon emission computed tomography (SPECT) we will image lungs to measure the decrease in pulmonary perfusion in vivo (known to occur in a ..
  16. GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence
    Kelly P Cosgrove; Fiscal Year: 2013
    ..of ethanol and nicotine on the GABAA- BZR in brain over time using [123I]iomazenil and single photon emission computed tomography (SPECT)...
  17. A Platform for Cancer Biomarker Validation: Image Fusion Using NIR Fluorescence
    Ali Kamen; Fiscal Year: 2013
    ..imaging (MRI), computed tomography (CT), positron emission tomography (PET), and/or single-photon emission computed tomography (SPECT) is the standard of care for the detection and staging of human cancer...
  18. Neuroimaging and Metabolomics Correlates of Cognitive Decline in Parkinson?s Dise
    Chaorui Huang; Fiscal Year: 2013
    ..interest in evaluating the potential of advanced noninvasive neuroimaging techniques, such as positron emission computed tomography (PET) and magnetic resonance imaging (MRI)...
  19. Novel MRI Methods for Neuronal Loss and Iron Quantification in Parkinsons Disease
    Shalom Michaeli; Fiscal Year: 2010
    ..Current radiotracing imaging techniques such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) lack the ability to ascertain dopamine neuronal counts as well as density...
  20. Striatal Dopamine Release in Response to Ultraviolet Light in Compulsive Tanners
    BRYON H ADINOFF; Fiscal Year: 2013
    ..tanning bed upon regional cerebral blood flow (rCBF), a measure of brain activity, using single-photon emission computed tomography (SPECT)...
  21. Cardiac Autonomic Function in Women
    PUJA KIRAN MEHTA; Fiscal Year: 2013
    ..1a) measuring cardiac sympathetic activity by 123iodine-metaiodobenzylguanidine (MIBG) single photon emission computed tomography (SPECT) imaging, and (1b) testing the effect of low heart rate stress on ANS sympathovagal balance in ..
  22. DYNAMIC CARDIAC SPECT IMAGING
    Grant T Gullberg; Fiscal Year: 2013
    ..Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is now the most widely applied noninvasive method for the ..
  23. Vevo 2100 High Resolution Ultrasound System For Preclinical Cancer Imaging
    Paul A Dayton; Fiscal Year: 2012
    ..use for both subject and user (in contrast to micro-CT, positron emission tomography, and single-photon emission computed tomography, which can involve substantial radiation dose), relatively portable, and advantageous because of real-..
  24. Tumor exosomes as agents of genetic change
    XANDRA OWENS BREAKEFIELD; Fiscal Year: 2011
    ..including Magnetic Resonance (MR), Positron Emission Tomography (PET) as well as Single Photon Emission Computed Tomography (SPECT)...
  25. Multivalent Nanophage Engineered as Dual Receptor Cancer Theranostic Agents.
    Susan L Deutscher; Fiscal Year: 2013
    ..will deliver high levels of a theranostic agent that can be simultaneously used for single photon emission computed tomography (SPECT) imaging in addition to providing a high dose of tumor-localized beta radiation...
  26. Quantitative Molecular Imaging of Heart Failure by 123I-MIBG SPECT
    Edward Ficaro; Fiscal Year: 2010
    ..Moreover, single photon emission computed tomography (SPECT) imaging has the potential for more accurate quantification of 123I-MIBG uptake and retention...
  27. Image Biomarker Development for TreatmentEfficacy of Prostate Cancer to the Bone
    Brian D Ross; Fiscal Year: 2012
    ..or magnetic resonance imaging remains essential, with positron emission tomography or single-photon emission computed tomography having potential applicability for diagnosing the presence of bone metastases...
  28. THE EFFECT OF SEDATION ON PAIN PERCEPTION
    Michael A Froelich; Fiscal Year: 2010
    ..regions of interest - sedation) in response to painful thermal stimuli with the use of two complementary brain imaging modalities, single photon emission computed tomography (SPECT) and functional magnetic resonance imaging (fMRI).
  29. Implementation and Evaluation of Imaging Decision Support Incorporating CER
    G Scott Gazelle; Fiscal Year: 2010
    ..imaging techniques, including computed tomography (CT), magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT) and positron emission tomography (PET) has dramatically changed the practice of medicine...
  30. VISION: Volumetric Imaging for Science Instruction of an Open Nature
    STEVEN DOUGLAS MOORE; Fiscal Year: 2010
    ..in magnetic resonance imaging (MRI), functional MRI (fMRI), computed tomography (CT), and single photon emission computed tomography (SPECT)...
  31. Improved Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics
    Rupak K Banerjee; Fiscal Year: 2013
    ..invasive modalities such as IVUS, FFR, and CFR and with non- invasive modalities, such as single photon emission computed tomography (SPECT) and a rela- tively newer technique of positron emission tomography (PET);2) To evaluate the ..
  32. Energy-Independent Single Photon Molecular Imaging Technology
    Youngho Seo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We propose to develop a completely new single photon emission computed tomography (SPECT) system using novel technologies employing cadmium zinc telluride (CZT), customized application-specific ..
  33. Novel imaging to identify lung mitochondrial injury and predict recovery
    Elizabeth R Jacobs; Fiscal Year: 2013
    ..with the extent of lung injury? (2) Can we track the severity of rat lung IR injury with single photon emission computed tomography/computed tomography (SPECT/CT) using nuclear medicine agents which target mitochondrial function and ..
  34. IMAGING FUNCTIONAL P-GLYCOPROTEIN TRANSPORT AT THE BBB IN ALZHEIMER'S DISEASE
    Vijay Sharma; Fiscal Year: 2011
    ..The proposed project involves development of a single photon emission computed tomography (SPECT) or positron-emission tomography (PET)-imaging agent, capable of interrogating this critical ..
  35. Innovative Solid-State Photodetector for Applications in Medical Imaging
    Woon Seng Choong; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Nuclear medical imaging such as single-photon emission computed tomography (SPECT) and positron emission computed tomography (PET) have become important tools in pre-clinical and clinical imaging ..
  36. Robotic SPECT for Biological Imaging Onboard Radiation Therapy Machines
    Fang Fang Yin; Fiscal Year: 2012
    ..Onboard biological imaging - for these tasks - could be provided by single-photon emission computed tomography (SPECT)...
  37. Photonic Bandgap Structures for Improved Timing and Spatial Resolution in PET Det
    BIPIN SINGH; Fiscal Year: 2010
    ..Imaging modalities such as positron emission tomography (PET), single photon emission computed tomography (SPECT), digital radiography (including digital mammography) and X-ray CT are critically important for ..
  38. BIOMEDICAL (BASIC)
    RICHARD TESTA; Fiscal Year: 2009
    ..into humans, production of a 203Pb-radiolabled beta-emitting ErbB-2-targeting peptide for single photon emission computed tomography (SPECT) imaging of cancer will be vital...
  39. Simultaneous Emission and Transmission Mammotomography
    Martin P Tornai; Fiscal Year: 2012
    The overall goal of this proposal is to develop a dual-modality single photon emission computed tomography (SPECT) and x-ray computed mammotomography (CmT) scanner for dedicated breast and axillary imaging, and to incorporate this system ..
  40. Tc-99m PIB Analogs for Imaging ??-Amyloid Deposition with SPECT
    NEALE S MASON; Fiscal Year: 2010
    ..However, many more hospitals have the capacity to perform single photon emission computed tomography (SPECT)...
  41. New Class of Numerical Observers for Nuclear Cardiology
    Jovan G Brankov; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Single-photon emission computed tomography (SPECT) imaging has become a standard component of modern cardiology...
  42. Simultaneous SPECT/CT with a single photon counting camera
    William C Barber; Fiscal Year: 2011
    ..develop a photon counting detector and read-out technology for higher spatial resolution single photon emission computed tomography (SPECT) and energy resolved single photon counting x-ray computed tomography (CT) at reduced dose...
  43. FDG-PET and V/Q SPECT Acquired During Radiation to Predict Outcomes in Lung Cance
    Feng Ming Kong; Fiscal Year: 2009
    ..18F] fluorodeoxyglucose positron emission tomography (FDG-PET) and ventilation/perfusion single photon emission computed tomography (V/Q SPECT), we have recently demonstrated a heterogeneous change in tumor activity and regional lung ..
  44. Measuring Left Ventricular Dyssynchrony from ECG-gated Myocardial Perfusion SPECT
    Ji Chen; Fiscal Year: 2012
    ..using our novel, quantitative multi-harmonic phase analysis (MHPA) of ECG-gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) study and by integrating this evaluation of LV dyssynchrony ..
  45. End-to-End Optimization of SPECT Instrumentation, Acquisition, and Reconstruction
    Jonathan M Links; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Single-Photon Emission Computed Tomography plays an important and well- validated role in the diagnosis and staging of a number of important cardiac diseases, and is widely used and available at many ..
  46. Microfluidic Platform for Preparation of Biomolecule Based Nuclear Imaging Probes
    David E Reichert; Fiscal Year: 2013
    ..of biomolecule based imaging probes for either Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging would greatly benefit both, preclinical research and clinical imaging...
  47. Probe Optimization for Prostate Cancer Detection
    CLIFFORD BERKMAN; Fiscal Year: 2013
    ..of the prostate cancer positron emission tomography (PET) imaging agent;and 3) develop single photon emission computed tomography (SPECT) imaging agents for prostate cancer based on PSMA targeting agents...
  48. Bioimage Suite: A structural, functional and metabolic image analysis platform
    Xenophon Papademetris; Fiscal Year: 2009
    ..images and will include functionality to process magnetic resonance spectroscopy (MRS), Single Photon Emission Computed Tomography (SPECT), and PET images...
  49. Segmented-Parallel-Beam Stationary Cardiac SPECT
    G LAWRENCE ZENG; Fiscal Year: 2013
    ..SPECT Abstract: The objective of this project is to develop a stationary cardiac SPECT (single photon emission computed tomography) system using a novel segmented parallel-hole collimator mounted on a large-area NaI(Tl) detector...
  50. New Design of a Sensor for Ultrahigh Performance SPECT Imaging
    VIVEK V NAGARKAR; Fiscal Year: 2010
    ..research is to develop a very high performance, cost-effective sensor for small animal single photon emission computed tomography (SPECT) imaging...
  51. High Performance Detectors for SPECT
    MICHAEL R SQUILLANTE; Fiscal Year: 2011
    High Performance Detectors for SPECT P.I.: Dr. Michael R. Squillante Abstract Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional ..
  52. Innovative reconstruction algorithms for undersampled SPECT
    Taly Gilat Schmidt; Fiscal Year: 2010
    ..by applicant): This project will develop an innovative reconstruction approach for single-photon emission computed tomography (SPECT) based on compressed sensing theory...
  53. FULLY THREE-DIMENSIONAL TOMOGRAPHY MEETING
    GRANT GULLBERG; Fiscal Year: 1993
    ..topics related to fully three-dimensional tomography such as cone-beam tomography in single photon emission computed tomography (SPECT) and x-ray computed tomography (CT) and the reconstruction of volume positron emission ..
  54. The Inveon PET/CT for Pre-Clinical Oncology Research
    Pat B Zanzonico; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Funds are being requested to purchase an Inveon PET (positron emission computed tomography) and dockable CT (transmission computed tomography) scanner (Siemens Medical Solutions USA, Inc, Knoxville, ..
  55. Flexible, High-Performance Electronics for Nuclear Medical Imaging
    Woon Seng Choong; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nuclear medical imaging such as single-photon emission computed tomography (SPECT) and positron emission computed tomography (PET) have become important tools in pre-clinical and clinical imaging ..
  56. High Resolution Detectors for Single Photon Cardiac Imaging
    Gerald Entine; Fiscal Year: 2010
    High Resolution Detectors for Single Photon Cardiac Imaging Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional distribution of a ..
  57. Assessment of Brain Iron and Neuronal Integrity Using Novel T1r and T2r MRI
    Shalom Michaeli; Fiscal Year: 2009
    ..Current radiotracing imaging techniques such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) lack the ability to ascertain dopamine neuronal counts as well as density...
  58. Novel Ovarian Cancer Detection Agents from Phage Display
    SUSAN DEUTSCHER; Fiscal Year: 2009
    ..peptides will be examined for their ability to image ovarian tumors in mice using Single Photon Emission Computed Tomography (SPECT)...
  59. SPECT Imaging and Parallel Computing
    Harrison H Barrett; Fiscal Year: 2013
    ..to enable new approaches to image science and image-quality assessment in the context of single-photon emission computed tomography (SPECT)...
  60. NEW CNS DOPAMINE RECEPTOR IMAGING AGENTS
    HANK KUNG; Fiscal Year: 2002
    The objective of this project is to develop new single photon emission computed tomography (SPECT) imaging agents for evaluating dopaminergic receptors of the central nervous system (CNS) in normal and disease states...
  61. SPECT RCBF IN LANGUAGE RECEPTION
    Emily Tobey; Fiscal Year: 2002
    ..traditional measures of speech perception with state-of-the-art brain imaging with Single Photon Emission Computed Tomography (SPECT)...
  62. PROTON METABOLITE MAPPING IN EXTRATEMPORAL EPILEPSY
    Xiaoping Hu; Fiscal Year: 1999
    ..non-invasive methods such as scalp electroencephalography, positron emission tomography, single photon emission computed tomography, magnetic resonance imaging and neurological testing...
  63. N-PINHOLE GAMMA-EMISSION COMPUTED TOMOGRAPHY
    KENNETH KORAL; Fiscal Year: 1980
    The subject matter of this proposal is N-pinhole gamma-emission computed tomography, a generic name for the tomography of the seven-pinhole collimator and the time-coded aperture...
  64. CORRECTIVE IMAGE RECONSTRUCTION METHODS FOR ECT
    Benjamin Tsui; Fiscal Year: 2000
    ..of this research is that corrective reconstruction methods that incorporate an accurate model of the emission computed tomography (ECT) imaging process will significantly improve the quality and quantitative accuracy of ECT images ..
  65. SEROTONIN RECEPTOR LIGANDS FOR SPECT IMAGING
    HANK KUNG; Fiscal Year: 2004
    ..is a competitive renewal application for a project (NS35120-04) on development of new single photon emission computed tomography (SPECT) imaging agents to evaluate serotonergic neurotransmission of the central nervous system (CNS)...
  66. SEROTONIN RECEPTOR LIGANDS FOR SPECT IMAGING
    HANK KUNG; Fiscal Year: 2001
    ..is a competitive renewal application for a project (NS35120-04) on development of new single photon emission computed tomography (SPECT) imaging agents to evaluate serotonergic neurotransmission of the central nervous system (CNS)...
  67. Image Reconstruction with Solid Srate SPECR
    LAWRENCE ZENG; Fiscal Year: 2005
    ..evaluation of image reconstruction methods for a rotating, strip gamma camera for SPECT (single photon emission computed tomography). The strip gamma camera consists of a CdZnTe detector and a tungsten slat collimator...
  68. New Dual-Mode Detector for Cerebrovascular Imaging
    CAROLYN TULL; Fiscal Year: 2001
    ..cerebrovascular imaging instrument, combining both computed tomography (CT) and single photon emission computed tomography (SPECT), for improved diagnosis of stroke...
  69. Innovative Cardiac Imaging Phantom Approach for Tc-99
    SHELBY CULLOM; Fiscal Year: 2003
    ..Single Photon Emission Computed Tomography (SPECT) of the myocardium is a valuable clinical tool for the diagnosis and assessment of coronary ..
  70. SPECT with pinholes separated by slats for high-sensitivity complete imaging
    SCOTT DEAN METZLER; Fiscal Year: 2010
    ..The overall goal of this project is to develop a new collimation technique for single photon emission computed tomography (SPECT) in nuclear medicine...
  71. Small Animal SPECT Using a Skew-Slit Collimator
    G Zeng; Fiscal Year: 2009
    ..main objective of this project is the development and evaluation of small animal SPECT (single photon emission computed tomography) using skew-slit collimators...
  72. X-SPECTTM for Functional & Anatomic Imaging In Vivo
    Sissy Jhiang; Fiscal Year: 2006
    ..small animal imaging system that combines x-ray Computed Tomography (CT) and Single Photon Emission Computed Tomography (SPECT)...
  73. FLEX TM microPET/SPECT/CT to Support Cancer Research at Harvard Medical School
    JOHN FRANGIONI; Fiscal Year: 2006
    ..animal positron emission tomography (PET) scanner in the LMA, and the only small animal single photon emission computed tomography (SPECT) scanner has limited availability and no computed tomography (CT) capabilities...
  74. TRAINING IN INNOVATIVE CANCER IMAGING TECHNOLOGIES
    Stanley Baum; Fiscal Year: 2000
    ..tomography (CT), optical tomography (OT), positron emission tomography (PET), and single photon emission computed tomography (SPECT), the trainees will be exposed to a broad spectrum of imaging research from coil and component ..