Genomes and Genes
Summary: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
Publications260 found, 100 shown here
- Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trialManfred Blobner
Klinik für Anästhesiologie der Technischen Universität München, Munich, Germany
Eur J Anaesthesiol 27:874-81. 2010..This study compared the efficacy of sugammadex and neostigmine for reversal of neuromuscular blockade induced by rocuronium for facilitating elective surgery.
- Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agentKoen Suy
Department of Anesthesiology and Critical Care Medicine, Onze Lieve Vrouw Ziekenhuis, Belgium
Anesthesiology 106:283-8. 2007..A secondary objective was to investigate the safety of single doses of sugammadex...
- Sugammadex: a review of its use in anaesthetic practiceLily P H Yang
Wolters Kluwer Health, Adis, Auckland, New Zealand
Drugs 69:919-42. 2009..a modified gamma-cyclodextrin, is the first selective relaxant binding agent indicated to reverse the neuromuscular blockade induced during general anaesthesia to facilitate surgical procedures...
- Reversal of rocuronium-induced neuromuscular blockade with sugammadex in pediatric and adult surgical patientsBenoit Plaud
Department of Anesthesiology and University of Caen Basse Normandie, Centre Hospitalier Universitaire de Côte de Nacre, Caen, France
Anesthesiology 110:284-94. 2009Sugammadex reverses neuromuscular blockade by chemical encapsulation of rocuronium...
- Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesiumPaul A Sloan
University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
Anesth Analg 94:123-4, table of contents. 2002..Even when using "short-acting" muscle relaxants, the anesthesiologist must routinely monitor the neuromuscular function...
- Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trialFriedrich K Pühringer
Department for Anesthesiology and Intensive Care Medicine, Klinikum am Steinenberg, Reutlingen, Germany
Anesthesiology 109:188-97. 2008..a novel, selective relaxant binding agent, was specifically designed to rapidly reverse rocuronium-induced neuromuscular blockade. The efficacy and safety of sugammadex for the reversal of profound, high-dose rocuronium-induced ..
- The effect of neuromuscular blockade on mask ventilationR D Warters
Department of Anesthesia and Perioperative Medicine, Division of Cardiothoracic Surgery and Anesthesia, Medical University of South Carolina, Charleston, SC, USA
Anaesthesia 66:163-7. 2011We wished to test the hypothesis that neuromuscular blockade facilitates mask ventilation...
- Botulinum toxin type A neuromuscular blockade in the treatment of lower extremity spasticity in cerebral palsy: a randomized, double-blind, placebo-controlled trial. BOTOX Study GroupL A Koman
Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1070, USA
J Pediatr Orthop 20:108-15. 2000..Patients in the BTX group demonstrated improved gait function and partial denervation of the injected muscle. No serious adverse events were reported...
- Postoperative residual neuromuscular block: a survey of managementC Baillard
Departement d Anesthesie Reanimation, EA 3409, Hopital Avicenne, APHP, 93009 Bobigny Cedex, France
Br J Anaesth 95:622-6. 2005..This study aims to evaluate changes of perioperative neuromuscular block management during the last decade in our institution and to quantify the incidence of postoperative residual neuromuscular block...
- Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trialKarin S Khuenl-Brady
Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Anesth Analg 110:64-73. 2010..relaxant binding drug that rapidly reverses rocuronium-induced and, to a lesser extent, vecuronium-induced neuromuscular blockade. In this study, we compared the efficacy of sugammadex and neostigmine for the reversal of vecuronium-..
- Consensus guidelines for sustained neuromuscular blockade in critically ill childrenStephen Playfor
Paediatric Intensive Care Unit, Royal Manchester Children s Hospital, Pendlebury, Manchester, UK
Paediatr Anaesth 17:881-7. 2007The United Kingdom Paediatric Intensive Care Society Sedation, Analgesia and Neuromuscular Blockade Working Group is a multidisciplinary expert panel created to produce consensus guidelines on sedation, analgesia and neuromuscular ..
- The undesirable effects of neuromuscular blocking drugsC Claudius
Department of Anaesthesia, Hillerød Hospital, Hillerød, Denmark
Anaesthesia 64:10-21. 2009..This article discusses the undesirable effects of the currently available neuromuscular blocking drugs including the definitions, diagnosis and causes of hypersensitivity reactions and postoperative residual curarisation...
- Rocuronium-induced neuromuscular blockade is affected by chronic phenytoin therapyJ Hernández-Palazón
Department of Anesthesia, Hospital Universitario, Virgen de la Arrixaca, Murcia, Spain
J Neurosurg Anesthesiol 13:79-82. 2001..We conclude that the duration of action of rocuronium and the recovery index were affected by chronic phenytoin therapy...
- Recovery from neuromuscular blockade after either bolus and prolonged infusions of cisatracurium or rocuronium using either isoflurane or propofol-based anestheticsW S Jellish
Department of Anesthesiology, Loyola University Medical Center, Maywood, Illinois 60153, USA
Anesth Analg 91:1250-5. 2000..Cisatracurium may be a more desired muscle relaxant for prolonged procedures because recovery was least affected by prolonged infusion...
- The neuromuscular effects of 0.6 mg kg(-1) rocuronium in elderly and young adults with or without renal failureS Kocabas
Ege University, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Izmir, Turkey
Eur J Anaesthesiol 25:940-6. 2008..This study aimed to investigate the neuromuscular effects of 0.6 mg kg(-1) rocuronium under propofol anaesthesia in young adults and elderly patients with or without renal failure...
- Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockadeElvan Erhan
Department of Anesthesiology and Reanimation, Ege University, Faculty of Medicine, Izmir, Turkey
Can J Anaesth 50:108-15. 2003..Other hypnotic drugs have not been thoroughly investigated in this regard. Intubating conditions with remifentanil followed by propofol, thiopentone or etomidate are compared in this study...
- Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropineOzlem Sacan
Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9068, USA
Anesth Analg 104:569-74. 2007..gamma] cyclodextrin compound, which encapsulates rocuronium to provide for a rapid reversal of residual neuromuscular blockade. We tested the hypothesis that sugammadex would provide for a more rapid reversal of a moderately profound ..
- Motor points for the neuromuscular blockade of the subscapularis muscleTim P Harrison
Department of Anatomy and Developmental Biology, University College London, and Great Ormond Street Hospital, London, UK
Arch Phys Med Rehabil 88:295-7. 2007..To locate the motor points of the subscapularis muscle in relation to palpable anatomic landmarks and hence suggest a technique for botulinum toxin injection into subscapularis applicable to patients of all ages...
- The effect of neuromuscular blockade on the efficiency of mask ventilation of the lungsM W P Goodwin
Nuffield Department of Anaesthetics, The John Radcliffe Hospital, Oxford OX3 9 DU, UK
Anaesthesia 58:60-3. 2003We conducted a two-part study to assess the practice of withholding neuromuscular blockade until the ability to ventilate the lungs using a bag and face mask (mask ventilation) has been established following induction of anaesthesia...
- The corrugator supercilii, not the orbicularis oculi, reflects rocuronium neuromuscular blockade at the laryngeal adductor musclesB Plaud
Department of Anesthesiology, University of Montreal, Quebec, Canada
Anesthesiology 95:96-101. 2001..In 12 other patients, laryngeal adductor neuromuscular blockade was assessed via the cuff of the tracheal tube and compared with the adductor pollicis and the corrugator ..
- Antineurotoxic activity of Galactia glaucescens against Crotalus durissus terrificus venomC A Dal Belo
State University of Campinas, UNICAMP, Department of Pharmacology, 13084 971, Campinas SP, Brazil
Fitoterapia 79:378-80. 2008..Ethanolic extract of leaves of Galactia glauscescens (GGE) at concentration of 100 and 500 microg/ml prevented the neuromuscular paralysis induced by Crotalus durissus terrificus venom on mouse phrenic nerve-diaphragm preparation...
- Sugammadex: cyclodextrins, development of selective binding agents, pharmacology, clinical development, and future directionsArezou Sadighi Akha
UCLA JCCC Clinical Research Unit, 10945 Le Conte Avenue, 3360 PVUB, Los Angeles, CA 90095, USA
Anesthesiol Clin 28:691-708. 2010..This article reviews cyclodextrins, development of selective binding agents, clinical development, and future directions of sugammadex...
- Treatment of upper extremity spasticity in stroke patients by focal neuronal or neuromuscular blockade: a systematic review of the literatureA A van Kuijk
Department of Rehabilitation Medicine, Sint Maartenskliniek, Nijimegen, The Netherlands
J Rehabil Med 34:51-61. 2002Studies published from January 1966 until October 2000 on the clinical effects of focal neuronal and neuromuscular blockade in post stroke upper limb spasticity were identified...
- Reversal of neuromuscular blockade by sugammadex does not affect EEG derived indices of depth of anesthesiaHanna Illman
Department of Anesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, P O Box 52, Kiinamyllynkatu 4 8, 20520 Turku, Finland
J Clin Monit Comput 24:371-6. 2010According to previous studies neuromuscular blockade may affect the depth of anesthesia...
- Epidurally administered mepivacaine delays recovery of train-of-four ratio from vecuronium-induced neuromuscular blockT Suzuki
Department of Anaesthesiology, Surugadai Nihon University Hospital, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo, 101 8309, Japan
Br J Anaesth 99:721-5. 2007..The aim of this study was to examine the efficacy of epidurally administered mepivacaine on recovery from vecuronium-induced neuromuscular block...
- Newer neuromuscular blocking agents: how do they compare with established agents?H J Sparr
Department of Anaesthesiology and Critical Care Medicine, The Leopold Franzens University of Innsbruck, Austria
Drugs 61:919-42. 2001..Like atracurium, cisatracurium undergoes Hofmann elimination. In contrast to atracurium, cisatracurium does not undergo hydrolysis by nonspecific plasma esterases. Moreover, about 77% of the drug is cleared by organ-dependent mechanisms...
- Selective relaxant binding agents for reversal of neuromuscular blockadeAnton Bom
Organon Laboratories Ltd, Department of Pharmacology, Newhouse ML1 5SH, UK
Curr Opin Pharmacol 7:298-302. 2007Traditionally, reversal of neuromuscular blockade during anaesthesia was achieved by increasing the acetylcholine concentration in the neuromuscular junction using acetylcholinesterase inhibitors...
- An anaesthetic protocol in the young domestic pig allowing neuromuscular blockade for studies of cardiac function following cardioplegic arrest and cardiopulmonary bypassT Fanneløp
Surgical Research Laboratory, Department of Surgical Sciences, University of Bergen, Bergen, Norway
Acta Anaesthesiol Scand 48:1144-54. 2004b>Neuromuscular blockade should, for ethical reasons, not be allowed in animal experiments unless the use is strongly motivated. Beforehand, the anaesthetic protocol must be documented without muscle relaxation in the species studied...
- Neuromuscular blockade and skeletal muscle weakness in critically ill patients: time to rethink the evidence?Zudin Puthucheary
Institute for Human Health and Performance, University College London, London, UK
Am J Respir Crit Care Med 185:911-7. 2012....
- Reversal of rocuronium-induced neuromuscular blockade by pyridostigmine in patients with Duchenne muscular dystrophyTino Muenster
Department of Anaesthesiology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Paediatr Anaesth 18:251-5. 2008..In patients with DMD recovery from a rocuronium-induced NMB is markedly delayed...
- Influence of local anesthetics on the neuromuscular blockade produced by rocuronium: effects of lidocaine and 50% enantiomeric excess bupivacaine on the neuromuscular junctionAngélica de Fátima de Assunção Braga
Departamento de Anestesiologia da FCM UNICAMP, Campinas, SP
Rev Bras Anestesiol 59:725-34. 2009The effects of local anesthetics (LA) on neuromuscular transmission and their influence on the neuromuscular blockade produced by competitive neuromuscular blockers have not been fully investigated...
- Train-of-four to monitor neuromuscular blockade?Curtis N Sessler
Chest 126:1018-22. 2004
- A Markov computer simulation model of the economics of neuromuscular blockade in patients with acute respiratory distress syndromeAlex Macario
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
BMC Med Inform Decis Mak 6:15. 2006..and/or a reduction in the incidence of AQMS from 25% to 21%, provide enough benefit to justify a drug with an additional expenditure of $267 (the difference in acquisition cost between a generic and brand name neuromuscular blocker)?..
- Ethyl acetate extract from black tea prevents neuromuscular blockade by botulinum neurotoxin type A in vitroEiki Satoh
Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, 080 8555, Japan
Int J Food Sci Nutr 56:543-50. 2005..These results indicate that ethyl acetate extract from black tea is the best source for searching for tea-derived inactivating substance(s) of botulinum neurotoxin...
- Sedation and neuromuscular blockade in paediatric intensive care: a review of current practice in the UKStephen D Playfor
Paediatric Intensive Care Unit, Royal Manchester Children s Hospital, Hospital Road, Pendlebury, Manchester M27 4HA, UK
Paediatr Anaesth 13:147-51. 2003Our aim was to investigate the current practice of sedation and neuromuscular blockade in critically ill children in paediatric intensive care units (PICUs) in the UK.
- Magnesium potentiates neuromuscular blockade with cisatracurium during cardiac surgeryAnne Marie Pinard
Department of Anesthesiology Maisonneuve Rosemont Hospital, University of Montreal, Montreal, Quebec, Canada
Can J Anaesth 50:172-8. 2003..It is used in cardiac anesthesia to prevent hypertension and arrhythmias. This study was performed to measure the interaction between magnesium and cisatracurium in cardiac surgery...
- [Comparison of laryngeal mask airway (LMA)- Proseal and the LMA-Classic in ventilated children receiving neuromuscular blockade]David R R Lardner
Division of Pediatric Anesthesia, Alberta Children s Hospital at the University of Calgary, 2888 Shaganappi Trail N W, Calgary, Alberta T3B 6A8, Canada
Can J Anaesth 55:29-35. 2008..mask airway (LMA)-Classic (CLMA) and LMA-Proseal (PLMA) in anesthetized children who have received neuromuscular blockade. Airway leak during intermittent positive pressure ventilation (IPPV) and adequacy of fibreoptic laryngeal ..
- Monitoring neuromuscular blockade at the vastus medialis muscle using phonomyographyGuillaume Michaud
Neuromuscular Research Group NRG, Department of Anesthesiology, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, Universite de Montreal, Montreal, Quebec, Canada
Can J Anaesth 52:795-800. 2005The vastus medialis muscle has been recently proposed as a new site for monitoring neuromuscular blockade (NMB)...
- Anatomic localization of motor points for the neuromuscular blockade of hand intrinsic muscles involved in thumb-in-palmSun Im
Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
Am J Phys Med Rehabil 87:703-9. 2008....
- Prolonged neuromuscular blockade as a result of malnutrition-induced pseudocholinesterase deficiencyAhtsham Niazi
Department of Anaesthesia and Intensive Care, St Vincent s University Hospital, Dublin, Ireland
J Clin Anesth 16:40-2. 2004....
- Impaired upper airway integrity by residual neuromuscular blockade: increased airway collapsibility and blunted genioglossus muscle activity in response to negative pharyngeal pressureFrank Herbstreit
Oberarzt, Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen and Universitätsklinikum Essen, Essen, Germany
Anesthesiology 110:1253-60. 2009Residual neuromuscular blockade increases the risk to develop postoperative complications. The authors hypothesized that minimal neuromuscular blockade (train-of-four [TOF] ratio 0...
- [Influence of epidural lidocaine injection on vecuronium-induced neuromuscular blockade]Kazuhiko Munakata
Department of Anesthesiology, Nihon University School of Medicine, Tokyo 173 0032
Masui 53:1377-80. 2004We investigated vecuronium-induced neuromuscular blockade in patients with continuous epidural lidocaine injection and those without epidural lidocaine.
- The influence of lidocaine and racemic bupivacaine on neuromuscular blockade produced by rocuronium. A study in rat phrenic nerve-diaphragm preparationVanessa Henriques Carvalho
Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Sao Paulo, Brazil
Acta Cir Bras 24:211-5. 2009To evaluate in vitro lidocaine and racemic bupivacaine effects in neuromuscular transmission and in neuromuscular blockade produced by rocuronium.
- Prolonged (more than ten hours) neuromuscular blockade after cardiac surgery: report of two casesLori Olivieri
Department of Anesthesia, McGill University and McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
Can J Anaesth 52:88-93. 2005We examine two cases of prolonged neuromuscular blockade (NMB) after cardiac surgery. To the best of our knowledge, these are the first reported cases of complete paralysis lasting more than ten hours after surgery.
- Impact of sustained neuromuscular blockade on outcome of mechanically ventilated childrenPaulo S L Da Silva
Pediatric Intensive Care Unit, Hospital Estadual de Diadema Universidade Federal de São Paulo, Sao Paulo, Brazil
Pediatr Int 52:438-43. 2010..Although NMBA are frequently used in PICU patients, their role in the PICU setting has not yet been clearly defined. The aim of this study was to describe the sustained administration of NMBA and its impact on outcome of PICU patients...
- Bonfils fiberscope: intubating conditions and hemodynamic changes without neuromuscular blockadeAtabak Najafi
Department of Anesthesiology and Critical Care Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
Acta Med Iran 49:201-7. 2011..To compare intubating conditions and hemodynamic changes between Bonfils Intubation Fiberscope and Macintosh laryngoscopy without administering neuromuscular blocking drugs (NMBDs)...
- Botulinum toxin type a neuromuscular blockade in the treatment of equinus foot deformity in cerebral palsy: a multicenter, open-label clinical trialL A Koman
Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1070, USA
Pediatrics 108:1062-71. 2001..Focal spasticity of the gastrocnemius-soleus muscles causes equinus gait in children with cerebral palsy (CP). Botulinum toxin type A (BTX-A), a neuromuscular blocking agent, reduces muscle tone/overactivity in dystonia, stroke, and CP...
- The neuromuscular blockade produced by pure alkaloid, mitragynine and methanol extract of kratom leaves (Mitragyna speciosa Korth.)Somsmorn Chittrakarn
Department of Pharmacology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand
J Ethnopharmacol 129:344-9. 2010..The effects of pure alkaloid, mitragynine and a methanolic extract of kratom leaves were investigated on neuromuscular junction and compound nerve action potential...
- The predisposition to inspiratory upper airway collapse during partial neuromuscular blockadeMatthias Eikermann
Oberarzt der Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
Am J Respir Crit Care Med 175:9-15. 2007Partial neuromuscular transmission failure by acetylcholine receptor blockade (neuromuscular blockade) or antibody-mediated functional loss (myasthenia gravis), even with a magnitude of muscle weakness that does not evoke respiratory ..
- A randomized, dose-finding, phase II study of the selective relaxant binding drug, Sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular blockScott B Groudine
Department of Anesthesiology, Albany Medical Center, Albany, New York 12208 34798, USA
Anesth Analg 104:555-62. 2007The reversal of a deep neuromuscular blockade remains a significant clinical problem...
- Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unitGlenn S Murphy
Department of Anesthesiology, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
Anesth Analg 107:130-7. 2008..The aim of this investigation was to assess and quantify the severity of neuromuscular blockade in patients with signs or symptoms of critical respiratory events (CREs) in the PACU.
- Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety studyIben F Sorgenfrei
Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
Anesthesiology 104:667-74. 2006..This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block...
- Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteersG Cammu
Department of Anaesthesiology and Critical Care Medicine, Onze Lieve Vrouw Clinic, Moorselbaan 164, 9300 Aalst, Belgium
Br J Anaesth 100:373-9. 2008..v. doses of sugammadex administered simultaneously with rocuronium or vecuronium to anaesthetized and non-anaesthetized healthy volunteers...
- Acceleromyography for use in scientific and clinical practice: a systematic review of the evidenceCasper Claudius
Copenhagen University Hospital, Rigshospitalet, Department of Anaesthesia, Copenhagen, Denmark
Anesthesiology 108:1117-40. 2008..A train-of-four ratio of 1.0 predicts with a high predictive value recovery of pulmonary and upper airway function from neuromuscular blockade.
- Residual curarization in the recovery room after vecuroniumC Baillard
Department of Anaesthesiology, University Hospital, Bobigny, France
Br J Anaesth 84:394-5. 2000..We conclude that it is necessary to antagonize residual block produced by vecuronium...
- Postoperative residual paralysis in outpatients versus inpatientsGuy Cammu
Department of Anesthesiology and Critical Care Medicine, OLV Clinic, Aalst, Belgium
Anesth Analg 102:426-9. 2006..Although the incidence of residual paralysis was less frequent in surgical outpatients, predictive criteria were not evident...
- Pharmacoeconomic impact of rational use guidelines on the provision of analgesia, sedation, and neuromuscular blockade in critical careM F Mascia
Department of Anesthesiology, State University of New York, Upstate Medical University, Syracuse, USA
Crit Care Med 28:2300-6. 2000To determine the cost-effectiveness and safety of a set of rational use guidelines for analgesia, sedation, and neuromuscular blockade in critically ill ventilated patients when compared with similar factors in standard prescribing.
- Antagonism of low degrees of atracurium-induced neuromuscular blockade: dose-effect relationship for neostigmineThomas Fuchs-Buder
Department of Anesthesia and Critical Care, Centre Hospitalier Universitaire, Institut de la Sante et de la Recherche Medicale, CIC EC CIE6, Nancy, France
Anesthesiology 112:34-40. 2010..The purpose of this study was to investigate the dose-effect relationship of neostigmine to antagonize residual paralysis corresponding to a TOF ratio of 0.4 and 0.6...
- Patient safety incidents involving neuromuscular blockade: analysis of the UK National Reporting and Learning System data from 2006 to 2008J Arnot-Smith
Royal Bolton Hospital Foundation Trust, Bolton, UK
Anaesthesia 65:1106-13. 2010b>Neuromuscular blockade is a powerful anaesthetic tool that has the potential for significant adverse outcomes...
- A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic hostAnton Bom
Department of Medicinal Chemistry, Newhouse ML1 5SH, Scotland, UK
Angew Chem Int Ed Engl 41:266-70. 2002
- Bispectral index guided timing of intubation without neuromuscular blockade during sevoflurane induction of anaesthesia in adultsR M van Twest
Anaesthetics Department, Gold Coast Hospital, Southport, Queensland, Australia
Anaesth Intensive Care 34:606-12. 2006..A target BIS value of 25 provides good to excellent intubating conditions and better intubating conditions than a target BIS of 40 during sevoflurane induction of anaesthesia without the use of neuromuscular blocking agents...
- The effect of residual neuromuscular blockade on the speed of reversal with sugammadexPaul F White
Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, 5161 Harry Hines Boulevard, CS 2 282, Dallas, TX 75390 9068, USA
Anesth Analg 108:846-51. 2009..modified gamma cyclodextrin compound which encapsulates rocuronium resulting in rapid reversal of residual neuromuscular blockade. We performed a post hoc analysis of data from a multicenter study designed to mimic standard clinical ..
- Safety and efficacy of sugammadex for the reversal of rocuronium-induced neuromuscular blockade in cardiac patients undergoing noncardiac surgeryVegard Dahl
Anaesthesia and Intensive Care, Asker and Baerum Hospital, Rud, Norway
Eur J Anaesthesiol 26:874-84. 2009....
- Antagonism of neuromuscular blockade but not muscle relaxation affects depth of anaesthesiaF C Vasella
Department of Anaesthesiology, University Hospital, CHUV BH 10, 1011 Lausanne, Switzerland
Br J Anaesth 94:742-7. 2005..Therefore we evaluated the effect of atracurium and neostigmine on bispectral index (BIS) and middle-latency auditory evoked potentials (AAI)...
- Monitoring of neuromuscular blockade at the P6 acupuncture point reduces the incidence of postoperative nausea and vomitingMichael Arnberger
Department of Anesthesiology, Inselspital, University Hospital Bern, Switzerland
Anesthesiology 107:903-8. 2007..b>Neuromuscular blockade during general anesthesia can be monitored with electrical peripheral nerve stimulation at the wrist...
- Competition between acetylcholine and a nondepolarizing muscle relaxant for binding to the postsynaptic receptors at the motor end plate: simulation of twitch strength and neuromuscular blockVladimir Nigrovic
Department of Anesthesiology and Pharmacology, Medical College of Ohio, Toledo, OH, USA
J Pharmacokinet Pharmacodyn 30:23-51. 2003..The goal of the study was to simulate twitch strength and neuromuscular block produced by nondepolarizing muscle relaxants...
- A comparison of two depths of prolonged neuromuscular blockade induced by cisatracurium in mechanically ventilated critically ill patientsFranck Lagneau
Department of Anesthesia and Intensive Care Unit, Beaujon Hospital, Universite Paris VII, 100 Boulevard du General Leclerc, 92 118 Clichy Cedex, France
Intensive Care Med 28:1735-41. 2002..To compare two levels of continuous cisatracurium-induced curarization in hypoxemic, ventilated patients...
- Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeysHans D de Boer
Department of Anesthesiology, Radboud University Medical Center Nijmegen, The Netherlands
Anesthesiology 104:718-23. 2006Reversal of neuromuscular blockade can be accomplished by chemical encapsulation of rocuronium by sugammadex, a synthetic gamma-cyclodextrin derivative...
- Postoperative upper airway obstruction after recovery of the train of four ratio of the adductor pollicis muscle from neuromuscular blockadeMatthias Eikermann
Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Germany
Anesth Analg 102:937-42. 2006Anesthetics, and even minimal residual neuromuscular blockade, may lead to upper airway obstruction (UAO). In this study we assessed by spirometry in patients with a train-of-four (TOF) ratio >0.9 the incidence of UAO (i.e...
- Accelerometry of adductor pollicis muscle predicts recovery of respiratory function from neuromuscular blockadeMatthias Eikermann
Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Germany
Anesthesiology 98:1333-7. 2003....
- Drugs to facilitate recovery of neuromuscular blockade and muscle strengthYuhji Saitoh
Department of Anesthesiology, Satte General Hospital, 4 14 24 Higashi, Satte 340 0114, Japan
J Anesth 19:302-8. 2005Several drugs that quicken recovery from neuromuscular blockade caused by vecuronium in anesthetized patients are reviewed...
- Sedation, analgesia, and neuromuscular blockade for high-frequency oscillatory ventilationCurtis N Sessler
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
Crit Care Med 33:S209-16. 2005....
- Recently published papers: the Jekyll and Hyde of oxygen, neuromuscular blockade and good vibrations?Jonathan Ball
General Intensive Care Unit, St George s Hospital, Blackshaw Road, London, UK
Crit Care 11:108. 2007..This issue's recently published papers commentary takes a long hard look at the surprisingly topically issue of oxygen. To give a balanced perspective, topical ventilatory studies are also discussed...
- Motion of the diaphragm in patients with chronic obstructive pulmonary disease while spontaneously breathing versus during positive pressure breathing after anesthesia and neuromuscular blockadeBruce S Kleinman
Anesthesiology and Diagnostic Radiology Services and Section of Cardiothoracic Surgery at the Edward Hines Jr Veterans Affairs Hospital, Hines, Illinois, 60141, USA
Anesthesiology 97:298-305. 2002..During positive pressure ventilation (PPV) after anesthesia and neuromuscular blockade and depending on tidal volume, the nondependent region (top) undergoes the greatest excursion, or the ..
- Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study: efficacy, safety, and pharmacokineticsHarald J Sparr
Department of Anesthesiology and Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria
Anesthesiology 106:935-43. 2007Sugammadex reverses the neuromuscular blocking effects of rocuronium by chemical encapsulation. The efficacy, safety, and pharmacokinetics of sugammadex for reversal of profound rocuronium-induced neuromuscular blockade were evaluated.
- Screening patients with prolonged neuromuscular blockade after succinylcholine and mivacuriumCharles Cerf
Department of Anesthesia and Intensive Care Unit, Henri Mondor Hospital, AP HP, Creteil, France
Anesth Analg 94:461-6, table of contents. 2002..a prospective cohort study in patients referred to our center between 1995 and 1999 for prolonged neuromuscular blockade after mivacurium or succinylcholine...
- Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patientMichael J Murray
Crit Care Med 30:142-56. 2002
- Paramedic-administered neuromuscular blockade improves prehospital intubation success in severely head-injured patientsDaniel P Davis
Department of Emergency Medicine, University of California, San Diego, California 92103 8676, USA
J Trauma 55:713-9. 2003....
- Decrease in functional residual capacity and ventilation homogeneity after neuromuscular blockade in anesthetized preschool children in the lateral positionBritta S von Ungern-Sternberg
Division of Anesthesia, University Children s Hospital, Basel, Switzerland
Paediatr Anaesth 17:841-5. 2007..The impact of neuromuscular blockade remains unknown...
- The effects of dexmedetomidine on neuromuscular blockade in human volunteersP O Talke
Department of Anesthesia, University of California, San Francisco 94143 0648, USA
Anesth Analg 88:633-9. 1999..We conclude that dexmedetomidine-induced vasoconstriction may alter the pharmacokinetics of rocuronium...
- Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesiaChristopher Rex
Klinik fur Anasthesiologie und Operative Intensivmedizin, Klinikum am Steinenberg, Reutlingen, Germany
Anesthesiology 111:30-5. 2009Sugammadex rapidly reverses neuromuscular blockade induced by bolus rocuronium doses, but it has not been investigated after continuous rocuronium infusion in surgical patients...
- A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesiaPhilippe Duvaldestin
Service d Anesthesie Reanimation, Hopital Henri Mondor, 94010 Creteil, France
Anesth Analg 110:74-82. 2010..of a new class of selective muscle relaxant binding drugs developed for the rapid and complete reversal of neuromuscular blockade induced by rocuronium and vecuronium...
- [Effects of atracurium pretreatment with magnesium on speed of onset, duration, and recovery of neuromuscular blockade]Hong Liang Wu
Department of Anesthesiology, Cancer Hospital, CAMS and PUMC, Beijing 100021, China
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 31:73-6. 2009..To determine the effects of atracurium pretreatment with magnesium on speed of onset, duration, and recovery of neuromuscular block...
- Is rocuronium an exception to the relation between onset and offset? A comparison with pipecuroniumA J England
John Hammond Department of Anaesthesia, East Surrey Hospital, Redhill, UK
Eur J Anaesthesiol 13:385-8. 1996..This suggests that onset, recovery, or both onset and recovery, from rocuronium blockade occur in a different manner to that of other non-depolarizing agents...
- An external monitoring site at the neck cannot be used to measure neuromuscular blockade of the larynxThomas M Hemmerling
Department of Anesthesiology, Universite de Montreal, Hotel Dieu, 3580, Rue st urbain, Montréal Québec H2W 1T8, Canada
Anesth Analg 100:1718-22. 2005Using phonomyography, a new monitoring technique of neuromuscular blockade (NMB), we compared NMB after mivacurium 0.1 mg/kg at the lateral cricoarytenoid muscle (LCA) with a possible external monitoring site of the larynx...
- Intraoperative acceleromyographic monitoring reduces the risk of residual neuromuscular blockade and adverse respiratory events in the postanesthesia care unitGlenn S Murphy
Department of Anesthesiology, Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
Anesthesiology 109:389-98. 2008Incomplete recovery from neuromuscular blockade in the postanesthesia care unit (PACU) may contribute to adverse postoperative respiratory events...
- Genotyping the butyrylcholinesterase in patients with prolonged neuromuscular block after succinylcholineSoledad Levano
Department of Anesthesia, University of Basel, Switzerland
Anesthesiology 102:531-5. 2005..This study was undertaken to evaluate the use of molecular genetic methods in patients with clinically prolonged neuromuscular block...
- The effect of neuromuscular blockade on pedicle screw stimulation thresholdsR E Minahan
Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
Spine (Phila Pa 1976) 25:2526-30. 2000STUDY DESIGN: Nerve root stimulation thresholds were studied relative to the level of neuromuscular blockade in patients undergoing lumbar decompression surgery...
- Residual neuromuscular blockade: a persistent clinical problemRichard M Pino
Int Anesthesiol Clin 44:77-90. 2006
- Monitoring neuromuscular blockadeGlenn S Murphy
Department of Anesthesia, Evanston Northwestern Healthcare, IL 60201, USA
Int Anesthesiol Clin 42:25-40. 2004
- Sedation, analgesia, and neuromuscular blockade of the critically ill adult: revised clinical practice guidelines for 2002Stanley A Nasraway
Tufts University School of Medicine, Department of Surgery, Tufts New England Medical Center, Boston, MA 02111, USA
Crit Care Med 30:117-8. 2002
- Time course of action of sugammadex (Org 25969) on rocuronium-induced block in the Rhesus monkey, using a simple model of equilibration of complex formationH D de Boer
Department of Anaesthesiology, Radboud University Medical Centre Nijmegen The Netherlands
Br J Anaesth 97:681-6. 2006..The present study determined the time course of the reversal action of sugammadex on rocuronium-induced block in the anaesthetized Rhesus monkey using train-of-four stimulation...
- Onset and duration of mivacurium-induced neuromuscular block in patients with Duchenne muscular dystrophyJ Schmidt
Department of Anaesthesiology, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
Br J Anaesth 95:769-72. 2005..To determine the response to mivacurium, we prospectively studied onset time and complete spontaneous recovery from mivacurium-induced neuromuscular block in patients with Duchenne muscular dystrophy (DMD)...
- Comparisons of the dose-response and recovery time course of vecuronium and atracurium in anesthetized chinese adult patientsFu Shan Xue
Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beyijng, PR of China
Acta Anaesthesiol Taiwan 45:9-14. 2007....
- Onset and duration of rocuronium-induced neuromuscular blockade in patients with Duchenne muscular dystrophyStefanie Wick
Department of Anesthesiology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Anesthesiology 102:915-9. 2005..The current study was conducted to determine the time to peak effect and the time for complete spontaneous recovery after a single dose of 0.6 mg/kg of rocuronium in patients with DMD...
- Gabexate mesilate hastens recovery from vecuronium-induced neuromuscular blockadeH Hattori
Fukushima Medical University School of Medicine, Department of Anesthesiology, Fukushima City, Fukushima, Japan
Eur J Anaesthesiol 22:20-4. 2005To test the hypothesis that gabexate mesilate, a protease inihibitor, hastens recovery from neuromuscular blockade, we examined the effect of gabexate mesilate on the recovery of vecuronium-induced neuromuscular blockade in anaesthetized ..
- How rational is muscle relaxation during cardiac surgery?G Cammu
Department of Anaesthesiology and Critical Care Medicine, OLV Clinic, Aalst, Belgium
Acta Anaesthesiol Belg 58:7-14. 2007..Therefore the continuous administration of neuromuscular blocking drugs, during cardiac surgery, seems unnecessary...
- Comparison between the Datex-Ohmeda M-NMT module and a force-displacement transducer for monitoring neuromuscular blockadeC Motamed
Hopital Henri Mondor, Service d Anesthesie Reanimation, AP HP et Université Paris XII, Creteil, France
Eur J Anaesthesiol 20:467-9. 2003..It incorporates a mechanosensor, which is a piezoelectric polymer attached to the hand. The module was compared with a force transducer in 30 patients requiring neuromuscular blockade.
- The effects of volatile anesthetics on intraoperative monitoring of myogenic motor-evoked potentials to transcranial electrical stimulation and on partial neuromuscular blockade during propofol/fentanyl/nitrous oxide anesthesia in humansKenichi Sekimoto
Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi City 3718511, Japan
J Neurosurg Anesthesiol 18:106-11. 2006..motor-evoked potentials (tcMEP) in humans anesthetized with propofol/fentanyl/nitrous oxide and on partial neuromuscular blockade (NMB)...
- TOF count at corrugator supercilii reflects abdominal muscles relaxation better than at adductor pollicisK Kirov
Anaesthesia and Intensive Care Department, Jean Verdier University Hospital of Paris, 93143 Bondy Cedex, France
Br J Anaesth 98:611-4. 2007..We compared the visual estimation of NMT at CSC and AP with electromyographic measurements of AB during recovery from a vecuronium block...
- Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuroniumD M Maybauer
Klinik für Anästhesiologie und Intensivmedizin, Philipps Universitat Marburg, Germany
Anaesthesia 62:12-7. 2007....
- Investigations Targeting Symptomatic Relief to Botulinum Neurotoxin A IntoxicatioKim D Janda; Fiscal Year: 2013..BoNT) are the etiological agents responsible for botulism, a disease characterized by peripheral neuromuscular blockade and a characteristic flaccid paralysis of humans...
- SENSORY AND MOTOR INTEGRATION IN THE SPINAL CORDPAUL S STEIN; Fiscal Year: 2010..CPGs produce coordinated motor output in model systems of spinal vertebrates immobilized with neuromuscular blockade. The immobilized spinal turtle produces the motor patterns of mixed-synergy rostral scratch, conventional-..
- ANESTHESIA RESEARCH CENTERWilliam Hamilton; Fiscal Year: 1980..The influence of hypokalemia on a nondepolarizing neuromuscular blockade. RA Mitchell: Regional histochemistry and electromyographic analysis of the cat respiratory diaphragm...
- PARALYSIS--ITS ANTAGONISM DURING SURGERY AND ANESTHESIARonald Miller; Fiscal Year: 1990..These studies will facilitate the safe administration of neuromuscular blocking drugs and their antagonists, and will help to avoid adverse effects such as prolonged neuromuscular blockade and postoperative respiratory failure.
- STRUCTURE FUNCTION ANALYSIS OF ALPHA NEUROTOXINSEdward Hawrot; Fiscal Year: 2002..in Pichia pastoris and double mutant cycle analysis to identify sites responsible for the high-affinity neuromuscular blockade produced by this alpha -neurotoxin...
- REVERSING THE EFFECTS OF ORGANOPHOSPHORUS PESTICIDESRON BRADLEY; Fiscal Year: 1990..The studies will measure both presynaptic and postsynaptic events and will also use a special apparatus where muscle contraction and compound action potential can be measured simultaneously...
- REGULATION OF SODIUM CHANNEL ISOFORM EXPRESSION IN VIVOMark Rich; Fiscal Year: 2000..SkM1 and SkM2 are independently regulated by activity in tissue culture and neuromuscular blockade in mature muscle...
- NEUROTRANSMITTER RECEPTOR DYNAMICS IN VIVOMohammed Akaaboune; Fiscal Year: 2002..The etiology of this devastating syndrome is not known but seems analogous to the effects of neuromuscular blockade observed in the preliminary work that supports this application...
- A NEUROMUSCULAR BLOCKADE MONITOR USING MOTION SENSORJOSEPH ORR; Fiscal Year: 1993There is a need to better monitor and control neuromuscular blockade, to measure whether a patient is adequately paralyzed during surgery and to facilitate mechanical ventilation in the Intensive Care Unit (ICU)...
- A NEUROMUSCULAR BLOCKADE MONITOR USING PIEZOELELECTRIC MDwayne Westenskow; Fiscal Year: 1991..The ease of application gives considerable advantage to the motion sensor over currently available techniques, making it the preferred method of monitoring neuromuscular relaxation...
- HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLSSteven Deem; Fiscal Year: 2002....
- Red Blood Cells, Nitric Oxide and Pulmonary CirculationSteven Deem; Fiscal Year: 2008..abstract_text> ..
- Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.Margie Peden Adams; Fiscal Year: 2007..The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. [unreadable] [unreadable] [unreadable]..
- ADENOSINE DERIVATIVES AND SYNAPTIC TRANSMISSIONEUGENE SILINSKY; Fiscal Year: 2003..Indeed, fast excitatory purinergic transmission with similar properties to the neurons we study occurs in regions of the CNS associated with cholinergic synapses and with Alzheimer's disease. ..
- Exacerbation of Alzheimer's Disease by Nitrous OxideW Kofke; Fiscal Year: 2003..Moreover, observation of a protective effect may result in discovery of an easily implemented preventative drug therapy for AD. ..