neuromuscular blockade

Summary

Summary: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.

Top Publications

  1. ncbi Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial
    Manfred Blobner
    Klinik für Anästhesiologie der Technischen Universität München, Munich, Germany
    Eur J Anaesthesiol 27:874-81. 2010
  2. ncbi Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent
    Koen Suy
    Department of Anesthesiology and Critical Care Medicine, Onze Lieve Vrouw Ziekenhuis, Belgium
    Anesthesiology 106:283-8. 2007
  3. ncbi Sugammadex: a review of its use in anaesthetic practice
    Lily P H Yang
    Wolters Kluwer Health, Adis, Auckland, New Zealand
    Drugs 69:919-42. 2009
  4. ncbi Reversal of rocuronium-induced neuromuscular blockade with sugammadex in pediatric and adult surgical patients
    Benoit Plaud
    Department of Anesthesiology and University of Caen Basse Normandie, Centre Hospitalier Universitaire de Côte de Nacre, Caen, France
    Anesthesiology 110:284-94. 2009
  5. ncbi Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesium
    Paul A Sloan
    University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Anesth Analg 94:123-4, table of contents. 2002
  6. ncbi Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial
    Friedrich K Pühringer
    Department for Anesthesiology and Intensive Care Medicine, Klinikum am Steinenberg, Reutlingen, Germany
    Anesthesiology 109:188-97. 2008
  7. ncbi The effect of neuromuscular blockade on mask ventilation
    R D Warters
    Department of Anesthesia and Perioperative Medicine, Division of Cardiothoracic Surgery and Anesthesia, Medical University of South Carolina, Charleston, SC, USA
    Anaesthesia 66:163-7. 2011
  8. ncbi Botulinum toxin type A neuromuscular blockade in the treatment of lower extremity spasticity in cerebral palsy: a randomized, double-blind, placebo-controlled trial. BOTOX Study Group
    L A Koman
    Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1070, USA
    J Pediatr Orthop 20:108-15. 2000
  9. ncbi Postoperative residual neuromuscular block: a survey of management
    C Baillard
    Departement d Anesthesie Reanimation, EA 3409, Hopital Avicenne, APHP, 93009 Bobigny Cedex, France
    Br J Anaesth 95:622-6. 2005
  10. ncbi Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial
    Karin S Khuenl-Brady
    Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Anesth Analg 110:64-73. 2010

Detail Information

Publications260 found, 100 shown here

  1. ncbi Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial
    Manfred Blobner
    Klinik für Anästhesiologie der Technischen Universität München, Munich, Germany
    Eur J Anaesthesiol 27:874-81. 2010
    ..This study compared the efficacy of sugammadex and neostigmine for reversal of neuromuscular blockade induced by rocuronium for facilitating elective surgery.
  2. ncbi Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent
    Koen Suy
    Department of Anesthesiology and Critical Care Medicine, Onze Lieve Vrouw Ziekenhuis, Belgium
    Anesthesiology 106:283-8. 2007
    ..A secondary objective was to investigate the safety of single doses of sugammadex...
  3. ncbi Sugammadex: a review of its use in anaesthetic practice
    Lily P H Yang
    Wolters Kluwer Health, Adis, Auckland, New Zealand
    Drugs 69:919-42. 2009
    ..a modified gamma-cyclodextrin, is the first selective relaxant binding agent indicated to reverse the neuromuscular blockade induced during general anaesthesia to facilitate surgical procedures...
  4. ncbi Reversal of rocuronium-induced neuromuscular blockade with sugammadex in pediatric and adult surgical patients
    Benoit Plaud
    Department of Anesthesiology and University of Caen Basse Normandie, Centre Hospitalier Universitaire de Côte de Nacre, Caen, France
    Anesthesiology 110:284-94. 2009
    Sugammadex reverses neuromuscular blockade by chemical encapsulation of rocuronium...
  5. ncbi Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesium
    Paul A Sloan
    University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Anesth Analg 94:123-4, table of contents. 2002
    ..Even when using "short-acting" muscle relaxants, the anesthesiologist must routinely monitor the neuromuscular function...
  6. ncbi Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial
    Friedrich K Pühringer
    Department for Anesthesiology and Intensive Care Medicine, Klinikum am Steinenberg, Reutlingen, Germany
    Anesthesiology 109:188-97. 2008
    ..a novel, selective relaxant binding agent, was specifically designed to rapidly reverse rocuronium-induced neuromuscular blockade. The efficacy and safety of sugammadex for the reversal of profound, high-dose rocuronium-induced ..
  7. ncbi The effect of neuromuscular blockade on mask ventilation
    R D Warters
    Department of Anesthesia and Perioperative Medicine, Division of Cardiothoracic Surgery and Anesthesia, Medical University of South Carolina, Charleston, SC, USA
    Anaesthesia 66:163-7. 2011
    We wished to test the hypothesis that neuromuscular blockade facilitates mask ventilation...
  8. ncbi Botulinum toxin type A neuromuscular blockade in the treatment of lower extremity spasticity in cerebral palsy: a randomized, double-blind, placebo-controlled trial. BOTOX Study Group
    L A Koman
    Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1070, USA
    J Pediatr Orthop 20:108-15. 2000
    ..Patients in the BTX group demonstrated improved gait function and partial denervation of the injected muscle. No serious adverse events were reported...
  9. ncbi Postoperative residual neuromuscular block: a survey of management
    C Baillard
    Departement d Anesthesie Reanimation, EA 3409, Hopital Avicenne, APHP, 93009 Bobigny Cedex, France
    Br J Anaesth 95:622-6. 2005
    ..This study aims to evaluate changes of perioperative neuromuscular block management during the last decade in our institution and to quantify the incidence of postoperative residual neuromuscular block...
  10. ncbi Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial
    Karin S Khuenl-Brady
    Medical University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Anesth Analg 110:64-73. 2010
    ..relaxant binding drug that rapidly reverses rocuronium-induced and, to a lesser extent, vecuronium-induced neuromuscular blockade. In this study, we compared the efficacy of sugammadex and neostigmine for the reversal of vecuronium-..
  11. ncbi Consensus guidelines for sustained neuromuscular blockade in critically ill children
    Stephen Playfor
    Paediatric Intensive Care Unit, Royal Manchester Children s Hospital, Pendlebury, Manchester, UK
    Paediatr Anaesth 17:881-7. 2007
    The United Kingdom Paediatric Intensive Care Society Sedation, Analgesia and Neuromuscular Blockade Working Group is a multidisciplinary expert panel created to produce consensus guidelines on sedation, analgesia and neuromuscular ..
  12. ncbi The undesirable effects of neuromuscular blocking drugs
    C Claudius
    Department of Anaesthesia, Hillerød Hospital, Hillerød, Denmark
    Anaesthesia 64:10-21. 2009
    ..This article discusses the undesirable effects of the currently available neuromuscular blocking drugs including the definitions, diagnosis and causes of hypersensitivity reactions and postoperative residual curarisation...
  13. ncbi Rocuronium-induced neuromuscular blockade is affected by chronic phenytoin therapy
    J Hernández-Palazón
    Department of Anesthesia, Hospital Universitario, Virgen de la Arrixaca, Murcia, Spain
    J Neurosurg Anesthesiol 13:79-82. 2001
    ..We conclude that the duration of action of rocuronium and the recovery index were affected by chronic phenytoin therapy...
  14. ncbi Recovery from neuromuscular blockade after either bolus and prolonged infusions of cisatracurium or rocuronium using either isoflurane or propofol-based anesthetics
    W S Jellish
    Department of Anesthesiology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Anesth Analg 91:1250-5. 2000
    ..Cisatracurium may be a more desired muscle relaxant for prolonged procedures because recovery was least affected by prolonged infusion...
  15. ncbi The neuromuscular effects of 0.6 mg kg(-1) rocuronium in elderly and young adults with or without renal failure
    S Kocabas
    Ege University, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Izmir, Turkey
    Eur J Anaesthesiol 25:940-6. 2008
    ..This study aimed to investigate the neuromuscular effects of 0.6 mg kg(-1) rocuronium under propofol anaesthesia in young adults and elderly patients with or without renal failure...
  16. ncbi Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade
    Elvan Erhan
    Department of Anesthesiology and Reanimation, Ege University, Faculty of Medicine, Izmir, Turkey
    Can J Anaesth 50:108-15. 2003
    ..Other hypnotic drugs have not been thoroughly investigated in this regard. Intubating conditions with remifentanil followed by propofol, thiopentone or etomidate are compared in this study...
  17. ncbi Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine
    Ozlem Sacan
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9068, USA
    Anesth Analg 104:569-74. 2007
    ..gamma] cyclodextrin compound, which encapsulates rocuronium to provide for a rapid reversal of residual neuromuscular blockade. We tested the hypothesis that sugammadex would provide for a more rapid reversal of a moderately profound ..
  18. ncbi Motor points for the neuromuscular blockade of the subscapularis muscle
    Tim P Harrison
    Department of Anatomy and Developmental Biology, University College London, and Great Ormond Street Hospital, London, UK
    Arch Phys Med Rehabil 88:295-7. 2007
    ..To locate the motor points of the subscapularis muscle in relation to palpable anatomic landmarks and hence suggest a technique for botulinum toxin injection into subscapularis applicable to patients of all ages...
  19. ncbi The effect of neuromuscular blockade on the efficiency of mask ventilation of the lungs
    M W P Goodwin
    Nuffield Department of Anaesthetics, The John Radcliffe Hospital, Oxford OX3 9 DU, UK
    Anaesthesia 58:60-3. 2003
    We conducted a two-part study to assess the practice of withholding neuromuscular blockade until the ability to ventilate the lungs using a bag and face mask (mask ventilation) has been established following induction of anaesthesia...
  20. ncbi The corrugator supercilii, not the orbicularis oculi, reflects rocuronium neuromuscular blockade at the laryngeal adductor muscles
    B Plaud
    Department of Anesthesiology, University of Montreal, Quebec, Canada
    Anesthesiology 95:96-101. 2001
    ..In 12 other patients, laryngeal adductor neuromuscular blockade was assessed via the cuff of the tracheal tube and compared with the adductor pollicis and the corrugator ..
  21. ncbi Antineurotoxic activity of Galactia glaucescens against Crotalus durissus terrificus venom
    C A Dal Belo
    State University of Campinas, UNICAMP, Department of Pharmacology, 13084 971, Campinas SP, Brazil
    Fitoterapia 79:378-80. 2008
    ..Ethanolic extract of leaves of Galactia glauscescens (GGE) at concentration of 100 and 500 microg/ml prevented the neuromuscular paralysis induced by Crotalus durissus terrificus venom on mouse phrenic nerve-diaphragm preparation...
  22. ncbi Sugammadex: cyclodextrins, development of selective binding agents, pharmacology, clinical development, and future directions
    Arezou Sadighi Akha
    UCLA JCCC Clinical Research Unit, 10945 Le Conte Avenue, 3360 PVUB, Los Angeles, CA 90095, USA
    Anesthesiol Clin 28:691-708. 2010
    ..This article reviews cyclodextrins, development of selective binding agents, clinical development, and future directions of sugammadex...
  23. ncbi Treatment of upper extremity spasticity in stroke patients by focal neuronal or neuromuscular blockade: a systematic review of the literature
    A A van Kuijk
    Department of Rehabilitation Medicine, Sint Maartenskliniek, Nijimegen, The Netherlands
    J Rehabil Med 34:51-61. 2002
    Studies published from January 1966 until October 2000 on the clinical effects of focal neuronal and neuromuscular blockade in post stroke upper limb spasticity were identified...
  24. ncbi Reversal of neuromuscular blockade by sugammadex does not affect EEG derived indices of depth of anesthesia
    Hanna Illman
    Department of Anesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, P O Box 52, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    J Clin Monit Comput 24:371-6. 2010
    According to previous studies neuromuscular blockade may affect the depth of anesthesia...
  25. ncbi Epidurally administered mepivacaine delays recovery of train-of-four ratio from vecuronium-induced neuromuscular block
    T Suzuki
    Department of Anaesthesiology, Surugadai Nihon University Hospital, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo, 101 8309, Japan
    Br J Anaesth 99:721-5. 2007
    ..The aim of this study was to examine the efficacy of epidurally administered mepivacaine on recovery from vecuronium-induced neuromuscular block...
  26. ncbi Newer neuromuscular blocking agents: how do they compare with established agents?
    H J Sparr
    Department of Anaesthesiology and Critical Care Medicine, The Leopold Franzens University of Innsbruck, Austria
    Drugs 61:919-42. 2001
    ..Like atracurium, cisatracurium undergoes Hofmann elimination. In contrast to atracurium, cisatracurium does not undergo hydrolysis by nonspecific plasma esterases. Moreover, about 77% of the drug is cleared by organ-dependent mechanisms...
  27. ncbi Selective relaxant binding agents for reversal of neuromuscular blockade
    Anton Bom
    Organon Laboratories Ltd, Department of Pharmacology, Newhouse ML1 5SH, UK
    Curr Opin Pharmacol 7:298-302. 2007
    Traditionally, reversal of neuromuscular blockade during anaesthesia was achieved by increasing the acetylcholine concentration in the neuromuscular junction using acetylcholinesterase inhibitors...
  28. ncbi An anaesthetic protocol in the young domestic pig allowing neuromuscular blockade for studies of cardiac function following cardioplegic arrest and cardiopulmonary bypass
    T Fanneløp
    Surgical Research Laboratory, Department of Surgical Sciences, University of Bergen, Bergen, Norway
    Acta Anaesthesiol Scand 48:1144-54. 2004
    b>Neuromuscular blockade should, for ethical reasons, not be allowed in animal experiments unless the use is strongly motivated. Beforehand, the anaesthetic protocol must be documented without muscle relaxation in the species studied...
  29. ncbi Neuromuscular blockade and skeletal muscle weakness in critically ill patients: time to rethink the evidence?
    Zudin Puthucheary
    Institute for Human Health and Performance, University College London, London, UK
    Am J Respir Crit Care Med 185:911-7. 2012
    ....
  30. ncbi Reversal of rocuronium-induced neuromuscular blockade by pyridostigmine in patients with Duchenne muscular dystrophy
    Tino Muenster
    Department of Anaesthesiology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Paediatr Anaesth 18:251-5. 2008
    ..In patients with DMD recovery from a rocuronium-induced NMB is markedly delayed...
  31. ncbi Influence of local anesthetics on the neuromuscular blockade produced by rocuronium: effects of lidocaine and 50% enantiomeric excess bupivacaine on the neuromuscular junction
    Angélica de Fátima de Assunção Braga
    Departamento de Anestesiologia da FCM UNICAMP, Campinas, SP
    Rev Bras Anestesiol 59:725-34. 2009
    The effects of local anesthetics (LA) on neuromuscular transmission and their influence on the neuromuscular blockade produced by competitive neuromuscular blockers have not been fully investigated...
  32. ncbi Train-of-four to monitor neuromuscular blockade?
    Curtis N Sessler
    Chest 126:1018-22. 2004
  33. pmc A Markov computer simulation model of the economics of neuromuscular blockade in patients with acute respiratory distress syndrome
    Alex Macario
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    BMC Med Inform Decis Mak 6:15. 2006
    ..and/or a reduction in the incidence of AQMS from 25% to 21%, provide enough benefit to justify a drug with an additional expenditure of $267 (the difference in acquisition cost between a generic and brand name neuromuscular blocker)?..
  34. ncbi Ethyl acetate extract from black tea prevents neuromuscular blockade by botulinum neurotoxin type A in vitro
    Eiki Satoh
    Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, 080 8555, Japan
    Int J Food Sci Nutr 56:543-50. 2005
    ..These results indicate that ethyl acetate extract from black tea is the best source for searching for tea-derived inactivating substance(s) of botulinum neurotoxin...
  35. ncbi Sedation and neuromuscular blockade in paediatric intensive care: a review of current practice in the UK
    Stephen D Playfor
    Paediatric Intensive Care Unit, Royal Manchester Children s Hospital, Hospital Road, Pendlebury, Manchester M27 4HA, UK
    Paediatr Anaesth 13:147-51. 2003
    Our aim was to investigate the current practice of sedation and neuromuscular blockade in critically ill children in paediatric intensive care units (PICUs) in the UK.
  36. ncbi Magnesium potentiates neuromuscular blockade with cisatracurium during cardiac surgery
    Anne Marie Pinard
    Department of Anesthesiology Maisonneuve Rosemont Hospital, University of Montreal, Montreal, Quebec, Canada
    Can J Anaesth 50:172-8. 2003
    ..It is used in cardiac anesthesia to prevent hypertension and arrhythmias. This study was performed to measure the interaction between magnesium and cisatracurium in cardiac surgery...
  37. ncbi [Comparison of laryngeal mask airway (LMA)- Proseal and the LMA-Classic in ventilated children receiving neuromuscular blockade]
    David R R Lardner
    Division of Pediatric Anesthesia, Alberta Children s Hospital at the University of Calgary, 2888 Shaganappi Trail N W, Calgary, Alberta T3B 6A8, Canada
    Can J Anaesth 55:29-35. 2008
    ..mask airway (LMA)-Classic (CLMA) and LMA-Proseal (PLMA) in anesthetized children who have received neuromuscular blockade. Airway leak during intermittent positive pressure ventilation (IPPV) and adequacy of fibreoptic laryngeal ..
  38. ncbi Monitoring neuromuscular blockade at the vastus medialis muscle using phonomyography
    Guillaume Michaud
    Neuromuscular Research Group NRG, Department of Anesthesiology, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, Universite de Montreal, Montreal, Quebec, Canada
    Can J Anaesth 52:795-800. 2005
    The vastus medialis muscle has been recently proposed as a new site for monitoring neuromuscular blockade (NMB)...
  39. ncbi Anatomic localization of motor points for the neuromuscular blockade of hand intrinsic muscles involved in thumb-in-palm
    Sun Im
    Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Am J Phys Med Rehabil 87:703-9. 2008
    ....
  40. ncbi Prolonged neuromuscular blockade as a result of malnutrition-induced pseudocholinesterase deficiency
    Ahtsham Niazi
    Department of Anaesthesia and Intensive Care, St Vincent s University Hospital, Dublin, Ireland
    J Clin Anesth 16:40-2. 2004
    ....
  41. ncbi Impaired upper airway integrity by residual neuromuscular blockade: increased airway collapsibility and blunted genioglossus muscle activity in response to negative pharyngeal pressure
    Frank Herbstreit
    Oberarzt, Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen and Universitätsklinikum Essen, Essen, Germany
    Anesthesiology 110:1253-60. 2009
    Residual neuromuscular blockade increases the risk to develop postoperative complications. The authors hypothesized that minimal neuromuscular blockade (train-of-four [TOF] ratio 0...
  42. ncbi [Influence of epidural lidocaine injection on vecuronium-induced neuromuscular blockade]
    Kazuhiko Munakata
    Department of Anesthesiology, Nihon University School of Medicine, Tokyo 173 0032
    Masui 53:1377-80. 2004
    We investigated vecuronium-induced neuromuscular blockade in patients with continuous epidural lidocaine injection and those without epidural lidocaine.
  43. ncbi The influence of lidocaine and racemic bupivacaine on neuromuscular blockade produced by rocuronium. A study in rat phrenic nerve-diaphragm preparation
    Vanessa Henriques Carvalho
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Sao Paulo, Brazil
    Acta Cir Bras 24:211-5. 2009
    To evaluate in vitro lidocaine and racemic bupivacaine effects in neuromuscular transmission and in neuromuscular blockade produced by rocuronium.
  44. ncbi Prolonged (more than ten hours) neuromuscular blockade after cardiac surgery: report of two cases
    Lori Olivieri
    Department of Anesthesia, McGill University and McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada
    Can J Anaesth 52:88-93. 2005
    We examine two cases of prolonged neuromuscular blockade (NMB) after cardiac surgery. To the best of our knowledge, these are the first reported cases of complete paralysis lasting more than ten hours after surgery.
  45. ncbi Impact of sustained neuromuscular blockade on outcome of mechanically ventilated children
    Paulo S L Da Silva
    Pediatric Intensive Care Unit, Hospital Estadual de Diadema Universidade Federal de São Paulo, Sao Paulo, Brazil
    Pediatr Int 52:438-43. 2010
    ..Although NMBA are frequently used in PICU patients, their role in the PICU setting has not yet been clearly defined. The aim of this study was to describe the sustained administration of NMBA and its impact on outcome of PICU patients...
  46. ncbi Bonfils fiberscope: intubating conditions and hemodynamic changes without neuromuscular blockade
    Atabak Najafi
    Department of Anesthesiology and Critical Care Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Acta Med Iran 49:201-7. 2011
    ..To compare intubating conditions and hemodynamic changes between Bonfils Intubation Fiberscope and Macintosh laryngoscopy without administering neuromuscular blocking drugs (NMBDs)...
  47. ncbi Botulinum toxin type a neuromuscular blockade in the treatment of equinus foot deformity in cerebral palsy: a multicenter, open-label clinical trial
    L A Koman
    Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1070, USA
    Pediatrics 108:1062-71. 2001
    ..Focal spasticity of the gastrocnemius-soleus muscles causes equinus gait in children with cerebral palsy (CP). Botulinum toxin type A (BTX-A), a neuromuscular blocking agent, reduces muscle tone/overactivity in dystonia, stroke, and CP...
  48. ncbi The neuromuscular blockade produced by pure alkaloid, mitragynine and methanol extract of kratom leaves (Mitragyna speciosa Korth.)
    Somsmorn Chittrakarn
    Department of Pharmacology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    J Ethnopharmacol 129:344-9. 2010
    ..The effects of pure alkaloid, mitragynine and a methanolic extract of kratom leaves were investigated on neuromuscular junction and compound nerve action potential...
  49. ncbi The predisposition to inspiratory upper airway collapse during partial neuromuscular blockade
    Matthias Eikermann
    Oberarzt der Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Am J Respir Crit Care Med 175:9-15. 2007
    Partial neuromuscular transmission failure by acetylcholine receptor blockade (neuromuscular blockade) or antibody-mediated functional loss (myasthenia gravis), even with a magnitude of muscle weakness that does not evoke respiratory ..
  50. ncbi A randomized, dose-finding, phase II study of the selective relaxant binding drug, Sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block
    Scott B Groudine
    Department of Anesthesiology, Albany Medical Center, Albany, New York 12208 34798, USA
    Anesth Analg 104:555-62. 2007
    The reversal of a deep neuromuscular blockade remains a significant clinical problem...
  51. ncbi Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit
    Glenn S Murphy
    Department of Anesthesiology, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Anesth Analg 107:130-7. 2008
    ..The aim of this investigation was to assess and quantify the severity of neuromuscular blockade in patients with signs or symptoms of critical respiratory events (CREs) in the PACU.
  52. ncbi Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study
    Iben F Sorgenfrei
    Department of Anaesthesia and Intensive Care, Copenhagen University Hospital, Rigshospitalet, Denmark
    Anesthesiology 104:667-74. 2006
    ..This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block...
  53. ncbi Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers
    G Cammu
    Department of Anaesthesiology and Critical Care Medicine, Onze Lieve Vrouw Clinic, Moorselbaan 164, 9300 Aalst, Belgium
    Br J Anaesth 100:373-9. 2008
    ..v. doses of sugammadex administered simultaneously with rocuronium or vecuronium to anaesthetized and non-anaesthetized healthy volunteers...
  54. ncbi Acceleromyography for use in scientific and clinical practice: a systematic review of the evidence
    Casper Claudius
    Copenhagen University Hospital, Rigshospitalet, Department of Anaesthesia, Copenhagen, Denmark
    Anesthesiology 108:1117-40. 2008
    ..A train-of-four ratio of 1.0 predicts with a high predictive value recovery of pulmonary and upper airway function from neuromuscular blockade.
  55. ncbi Residual curarization in the recovery room after vecuronium
    C Baillard
    Department of Anaesthesiology, University Hospital, Bobigny, France
    Br J Anaesth 84:394-5. 2000
    ..We conclude that it is necessary to antagonize residual block produced by vecuronium...
  56. ncbi Postoperative residual paralysis in outpatients versus inpatients
    Guy Cammu
    Department of Anesthesiology and Critical Care Medicine, OLV Clinic, Aalst, Belgium
    Anesth Analg 102:426-9. 2006
    ..Although the incidence of residual paralysis was less frequent in surgical outpatients, predictive criteria were not evident...
  57. ncbi Pharmacoeconomic impact of rational use guidelines on the provision of analgesia, sedation, and neuromuscular blockade in critical care
    M F Mascia
    Department of Anesthesiology, State University of New York, Upstate Medical University, Syracuse, USA
    Crit Care Med 28:2300-6. 2000
    To determine the cost-effectiveness and safety of a set of rational use guidelines for analgesia, sedation, and neuromuscular blockade in critically ill ventilated patients when compared with similar factors in standard prescribing.
  58. ncbi Antagonism of low degrees of atracurium-induced neuromuscular blockade: dose-effect relationship for neostigmine
    Thomas Fuchs-Buder
    Department of Anesthesia and Critical Care, Centre Hospitalier Universitaire, Institut de la Sante et de la Recherche Medicale, CIC EC CIE6, Nancy, France
    Anesthesiology 112:34-40. 2010
    ..The purpose of this study was to investigate the dose-effect relationship of neostigmine to antagonize residual paralysis corresponding to a TOF ratio of 0.4 and 0.6...
  59. ncbi Patient safety incidents involving neuromuscular blockade: analysis of the UK National Reporting and Learning System data from 2006 to 2008
    J Arnot-Smith
    Royal Bolton Hospital Foundation Trust, Bolton, UK
    Anaesthesia 65:1106-13. 2010
    b>Neuromuscular blockade is a powerful anaesthetic tool that has the potential for significant adverse outcomes...
  60. ncbi A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host
    Anton Bom
    Department of Medicinal Chemistry, Newhouse ML1 5SH, Scotland, UK
    Angew Chem Int Ed Engl 41:266-70. 2002
  61. ncbi Bispectral index guided timing of intubation without neuromuscular blockade during sevoflurane induction of anaesthesia in adults
    R M van Twest
    Anaesthetics Department, Gold Coast Hospital, Southport, Queensland, Australia
    Anaesth Intensive Care 34:606-12. 2006
    ..A target BIS value of 25 provides good to excellent intubating conditions and better intubating conditions than a target BIS of 40 during sevoflurane induction of anaesthesia without the use of neuromuscular blocking agents...
  62. ncbi The effect of residual neuromuscular blockade on the speed of reversal with sugammadex
    Paul F White
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, 5161 Harry Hines Boulevard, CS 2 282, Dallas, TX 75390 9068, USA
    Anesth Analg 108:846-51. 2009
    ..modified gamma cyclodextrin compound which encapsulates rocuronium resulting in rapid reversal of residual neuromuscular blockade. We performed a post hoc analysis of data from a multicenter study designed to mimic standard clinical ..
  63. ncbi Safety and efficacy of sugammadex for the reversal of rocuronium-induced neuromuscular blockade in cardiac patients undergoing noncardiac surgery
    Vegard Dahl
    Anaesthesia and Intensive Care, Asker and Baerum Hospital, Rud, Norway
    Eur J Anaesthesiol 26:874-84. 2009
    ....
  64. ncbi Antagonism of neuromuscular blockade but not muscle relaxation affects depth of anaesthesia
    F C Vasella
    Department of Anaesthesiology, University Hospital, CHUV BH 10, 1011 Lausanne, Switzerland
    Br J Anaesth 94:742-7. 2005
    ..Therefore we evaluated the effect of atracurium and neostigmine on bispectral index (BIS) and middle-latency auditory evoked potentials (AAI)...
  65. ncbi Monitoring of neuromuscular blockade at the P6 acupuncture point reduces the incidence of postoperative nausea and vomiting
    Michael Arnberger
    Department of Anesthesiology, Inselspital, University Hospital Bern, Switzerland
    Anesthesiology 107:903-8. 2007
    ..b>Neuromuscular blockade during general anesthesia can be monitored with electrical peripheral nerve stimulation at the wrist...
  66. ncbi Competition between acetylcholine and a nondepolarizing muscle relaxant for binding to the postsynaptic receptors at the motor end plate: simulation of twitch strength and neuromuscular block
    Vladimir Nigrovic
    Department of Anesthesiology and Pharmacology, Medical College of Ohio, Toledo, OH, USA
    J Pharmacokinet Pharmacodyn 30:23-51. 2003
    ..The goal of the study was to simulate twitch strength and neuromuscular block produced by nondepolarizing muscle relaxants...
  67. ncbi A comparison of two depths of prolonged neuromuscular blockade induced by cisatracurium in mechanically ventilated critically ill patients
    Franck Lagneau
    Department of Anesthesia and Intensive Care Unit, Beaujon Hospital, Universite Paris VII, 100 Boulevard du General Leclerc, 92 118 Clichy Cedex, France
    Intensive Care Med 28:1735-41. 2002
    ..To compare two levels of continuous cisatracurium-induced curarization in hypoxemic, ventilated patients...
  68. ncbi Reversal of profound rocuronium neuromuscular blockade by sugammadex in anesthetized rhesus monkeys
    Hans D de Boer
    Department of Anesthesiology, Radboud University Medical Center Nijmegen, The Netherlands
    Anesthesiology 104:718-23. 2006
    Reversal of neuromuscular blockade can be accomplished by chemical encapsulation of rocuronium by sugammadex, a synthetic gamma-cyclodextrin derivative...
  69. ncbi Postoperative upper airway obstruction after recovery of the train of four ratio of the adductor pollicis muscle from neuromuscular blockade
    Matthias Eikermann
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Germany
    Anesth Analg 102:937-42. 2006
    Anesthetics, and even minimal residual neuromuscular blockade, may lead to upper airway obstruction (UAO). In this study we assessed by spirometry in patients with a train-of-four (TOF) ratio >0.9 the incidence of UAO (i.e...
  70. ncbi Accelerometry of adductor pollicis muscle predicts recovery of respiratory function from neuromuscular blockade
    Matthias Eikermann
    Klinik für Anästhesiologie und Intensivmedizin, Universitatsklinikum Essen, Germany
    Anesthesiology 98:1333-7. 2003
    ....
  71. ncbi Drugs to facilitate recovery of neuromuscular blockade and muscle strength
    Yuhji Saitoh
    Department of Anesthesiology, Satte General Hospital, 4 14 24 Higashi, Satte 340 0114, Japan
    J Anesth 19:302-8. 2005
    Several drugs that quicken recovery from neuromuscular blockade caused by vecuronium in anesthetized patients are reviewed...
  72. ncbi Sedation, analgesia, and neuromuscular blockade for high-frequency oscillatory ventilation
    Curtis N Sessler
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
    Crit Care Med 33:S209-16. 2005
    ....
  73. pmc Recently published papers: the Jekyll and Hyde of oxygen, neuromuscular blockade and good vibrations?
    Jonathan Ball
    General Intensive Care Unit, St George s Hospital, Blackshaw Road, London, UK
    Crit Care 11:108. 2007
    ..This issue's recently published papers commentary takes a long hard look at the surprisingly topically issue of oxygen. To give a balanced perspective, topical ventilatory studies are also discussed...
  74. ncbi Motion of the diaphragm in patients with chronic obstructive pulmonary disease while spontaneously breathing versus during positive pressure breathing after anesthesia and neuromuscular blockade
    Bruce S Kleinman
    Anesthesiology and Diagnostic Radiology Services and Section of Cardiothoracic Surgery at the Edward Hines Jr Veterans Affairs Hospital, Hines, Illinois, 60141, USA
    Anesthesiology 97:298-305. 2002
    ..During positive pressure ventilation (PPV) after anesthesia and neuromuscular blockade and depending on tidal volume, the nondependent region (top) undergoes the greatest excursion, or the ..
  75. ncbi Early reversal of profound rocuronium-induced neuromuscular blockade by sugammadex in a randomized multicenter study: efficacy, safety, and pharmacokinetics
    Harald J Sparr
    Department of Anesthesiology and Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria
    Anesthesiology 106:935-43. 2007
    Sugammadex reverses the neuromuscular blocking effects of rocuronium by chemical encapsulation. The efficacy, safety, and pharmacokinetics of sugammadex for reversal of profound rocuronium-induced neuromuscular blockade were evaluated.
  76. ncbi Screening patients with prolonged neuromuscular blockade after succinylcholine and mivacurium
    Charles Cerf
    Department of Anesthesia and Intensive Care Unit, Henri Mondor Hospital, AP HP, Creteil, France
    Anesth Analg 94:461-6, table of contents. 2002
    ..a prospective cohort study in patients referred to our center between 1995 and 1999 for prolonged neuromuscular blockade after mivacurium or succinylcholine...
  77. ncbi Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient
    Michael J Murray
    Crit Care Med 30:142-56. 2002
  78. ncbi Paramedic-administered neuromuscular blockade improves prehospital intubation success in severely head-injured patients
    Daniel P Davis
    Department of Emergency Medicine, University of California, San Diego, California 92103 8676, USA
    J Trauma 55:713-9. 2003
    ....
  79. ncbi Decrease in functional residual capacity and ventilation homogeneity after neuromuscular blockade in anesthetized preschool children in the lateral position
    Britta S von Ungern-Sternberg
    Division of Anesthesia, University Children s Hospital, Basel, Switzerland
    Paediatr Anaesth 17:841-5. 2007
    ..The impact of neuromuscular blockade remains unknown...
  80. ncbi The effects of dexmedetomidine on neuromuscular blockade in human volunteers
    P O Talke
    Department of Anesthesia, University of California, San Francisco 94143 0648, USA
    Anesth Analg 88:633-9. 1999
    ..We conclude that dexmedetomidine-induced vasoconstriction may alter the pharmacokinetics of rocuronium...
  81. ncbi Reversal of neuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients randomized to sevoflurane or propofol maintenance anesthesia
    Christopher Rex
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Klinikum am Steinenberg, Reutlingen, Germany
    Anesthesiology 111:30-5. 2009
    Sugammadex rapidly reverses neuromuscular blockade induced by bolus rocuronium doses, but it has not been investigated after continuous rocuronium infusion in surgical patients...
  82. ncbi A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia
    Philippe Duvaldestin
    Service d Anesthesie Reanimation, Hopital Henri Mondor, 94010 Creteil, France
    Anesth Analg 110:74-82. 2010
    ..of a new class of selective muscle relaxant binding drugs developed for the rapid and complete reversal of neuromuscular blockade induced by rocuronium and vecuronium...
  83. ncbi [Effects of atracurium pretreatment with magnesium on speed of onset, duration, and recovery of neuromuscular blockade]
    Hong Liang Wu
    Department of Anesthesiology, Cancer Hospital, CAMS and PUMC, Beijing 100021, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 31:73-6. 2009
    ..To determine the effects of atracurium pretreatment with magnesium on speed of onset, duration, and recovery of neuromuscular block...
  84. ncbi Is rocuronium an exception to the relation between onset and offset? A comparison with pipecuronium
    A J England
    John Hammond Department of Anaesthesia, East Surrey Hospital, Redhill, UK
    Eur J Anaesthesiol 13:385-8. 1996
    ..This suggests that onset, recovery, or both onset and recovery, from rocuronium blockade occur in a different manner to that of other non-depolarizing agents...
  85. ncbi An external monitoring site at the neck cannot be used to measure neuromuscular blockade of the larynx
    Thomas M Hemmerling
    Department of Anesthesiology, Universite de Montreal, Hotel Dieu, 3580, Rue st urbain, Montréal Québec H2W 1T8, Canada
    Anesth Analg 100:1718-22. 2005
    Using phonomyography, a new monitoring technique of neuromuscular blockade (NMB), we compared NMB after mivacurium 0.1 mg/kg at the lateral cricoarytenoid muscle (LCA) with a possible external monitoring site of the larynx...
  86. ncbi Intraoperative acceleromyographic monitoring reduces the risk of residual neuromuscular blockade and adverse respiratory events in the postanesthesia care unit
    Glenn S Murphy
    Department of Anesthesiology, Evanston Northwestern Healthcare, Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
    Anesthesiology 109:389-98. 2008
    Incomplete recovery from neuromuscular blockade in the postanesthesia care unit (PACU) may contribute to adverse postoperative respiratory events...
  87. ncbi Genotyping the butyrylcholinesterase in patients with prolonged neuromuscular block after succinylcholine
    Soledad Levano
    Department of Anesthesia, University of Basel, Switzerland
    Anesthesiology 102:531-5. 2005
    ..This study was undertaken to evaluate the use of molecular genetic methods in patients with clinically prolonged neuromuscular block...
  88. ncbi The effect of neuromuscular blockade on pedicle screw stimulation thresholds
    R E Minahan
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Spine (Phila Pa 1976) 25:2526-30. 2000
    STUDY DESIGN: Nerve root stimulation thresholds were studied relative to the level of neuromuscular blockade in patients undergoing lumbar decompression surgery...
  89. ncbi Residual neuromuscular blockade: a persistent clinical problem
    Richard M Pino
    Int Anesthesiol Clin 44:77-90. 2006
  90. ncbi Monitoring neuromuscular blockade
    Glenn S Murphy
    Department of Anesthesia, Evanston Northwestern Healthcare, IL 60201, USA
    Int Anesthesiol Clin 42:25-40. 2004
  91. ncbi Sedation, analgesia, and neuromuscular blockade of the critically ill adult: revised clinical practice guidelines for 2002
    Stanley A Nasraway
    Tufts University School of Medicine, Department of Surgery, Tufts New England Medical Center, Boston, MA 02111, USA
    Crit Care Med 30:117-8. 2002
  92. ncbi Time course of action of sugammadex (Org 25969) on rocuronium-induced block in the Rhesus monkey, using a simple model of equilibration of complex formation
    H D de Boer
    Department of Anaesthesiology, Radboud University Medical Centre Nijmegen The Netherlands
    Br J Anaesth 97:681-6. 2006
    ..The present study determined the time course of the reversal action of sugammadex on rocuronium-induced block in the anaesthetized Rhesus monkey using train-of-four stimulation...
  93. ncbi Onset and duration of mivacurium-induced neuromuscular block in patients with Duchenne muscular dystrophy
    J Schmidt
    Department of Anaesthesiology, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Br J Anaesth 95:769-72. 2005
    ..To determine the response to mivacurium, we prospectively studied onset time and complete spontaneous recovery from mivacurium-induced neuromuscular block in patients with Duchenne muscular dystrophy (DMD)...
  94. ncbi Comparisons of the dose-response and recovery time course of vecuronium and atracurium in anesthetized chinese adult patients
    Fu Shan Xue
    Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beyijng, PR of China
    Acta Anaesthesiol Taiwan 45:9-14. 2007
    ....
  95. ncbi Onset and duration of rocuronium-induced neuromuscular blockade in patients with Duchenne muscular dystrophy
    Stefanie Wick
    Department of Anesthesiology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Anesthesiology 102:915-9. 2005
    ..The current study was conducted to determine the time to peak effect and the time for complete spontaneous recovery after a single dose of 0.6 mg/kg of rocuronium in patients with DMD...
  96. ncbi Gabexate mesilate hastens recovery from vecuronium-induced neuromuscular blockade
    H Hattori
    Fukushima Medical University School of Medicine, Department of Anesthesiology, Fukushima City, Fukushima, Japan
    Eur J Anaesthesiol 22:20-4. 2005
    To test the hypothesis that gabexate mesilate, a protease inihibitor, hastens recovery from neuromuscular blockade, we examined the effect of gabexate mesilate on the recovery of vecuronium-induced neuromuscular blockade in anaesthetized ..
  97. ncbi How rational is muscle relaxation during cardiac surgery?
    G Cammu
    Department of Anaesthesiology and Critical Care Medicine, OLV Clinic, Aalst, Belgium
    Acta Anaesthesiol Belg 58:7-14. 2007
    ..Therefore the continuous administration of neuromuscular blocking drugs, during cardiac surgery, seems unnecessary...
  98. ncbi Comparison between the Datex-Ohmeda M-NMT module and a force-displacement transducer for monitoring neuromuscular blockade
    C Motamed
    Hopital Henri Mondor, Service d Anesthesie Reanimation, AP HP et Université Paris XII, Creteil, France
    Eur J Anaesthesiol 20:467-9. 2003
    ..It incorporates a mechanosensor, which is a piezoelectric polymer attached to the hand. The module was compared with a force transducer in 30 patients requiring neuromuscular blockade.
  99. ncbi The effects of volatile anesthetics on intraoperative monitoring of myogenic motor-evoked potentials to transcranial electrical stimulation and on partial neuromuscular blockade during propofol/fentanyl/nitrous oxide anesthesia in humans
    Kenichi Sekimoto
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi City 3718511, Japan
    J Neurosurg Anesthesiol 18:106-11. 2006
    ..motor-evoked potentials (tcMEP) in humans anesthetized with propofol/fentanyl/nitrous oxide and on partial neuromuscular blockade (NMB)...
  100. ncbi TOF count at corrugator supercilii reflects abdominal muscles relaxation better than at adductor pollicis
    K Kirov
    Anaesthesia and Intensive Care Department, Jean Verdier University Hospital of Paris, 93143 Bondy Cedex, France
    Br J Anaesth 98:611-4. 2007
    ..We compared the visual estimation of NMT at CSC and AP with electromyographic measurements of AB during recovery from a vecuronium block...
  101. ncbi Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium
    D M Maybauer
    Klinik für Anästhesiologie und Intensivmedizin, Philipps Universitat Marburg, Germany
    Anaesthesia 62:12-7. 2007
    ....

Research Grants16

  1. Investigations Targeting Symptomatic Relief to Botulinum Neurotoxin A Intoxicatio
    Kim D Janda; Fiscal Year: 2013
    ..BoNT) are the etiological agents responsible for botulism, a disease characterized by peripheral neuromuscular blockade and a characteristic flaccid paralysis of humans...
  2. SENSORY AND MOTOR INTEGRATION IN THE SPINAL CORD
    PAUL S STEIN; Fiscal Year: 2010
    ..CPGs produce coordinated motor output in model systems of spinal vertebrates immobilized with neuromuscular blockade. The immobilized spinal turtle produces the motor patterns of mixed-synergy rostral scratch, conventional-..
  3. ANESTHESIA RESEARCH CENTER
    William Hamilton; Fiscal Year: 1980
    ..The influence of hypokalemia on a nondepolarizing neuromuscular blockade. RA Mitchell: Regional histochemistry and electromyographic analysis of the cat respiratory diaphragm...
  4. PARALYSIS--ITS ANTAGONISM DURING SURGERY AND ANESTHESIA
    Ronald Miller; Fiscal Year: 1990
    ..These studies will facilitate the safe administration of neuromuscular blocking drugs and their antagonists, and will help to avoid adverse effects such as prolonged neuromuscular blockade and postoperative respiratory failure.
  5. STRUCTURE FUNCTION ANALYSIS OF ALPHA NEUROTOXINS
    Edward Hawrot; Fiscal Year: 2002
    ..in Pichia pastoris and double mutant cycle analysis to identify sites responsible for the high-affinity neuromuscular blockade produced by this alpha -neurotoxin...
  6. REVERSING THE EFFECTS OF ORGANOPHOSPHORUS PESTICIDES
    RON BRADLEY; Fiscal Year: 1990
    ..The studies will measure both presynaptic and postsynaptic events and will also use a special apparatus where muscle contraction and compound action potential can be measured simultaneously...
  7. REGULATION OF SODIUM CHANNEL ISOFORM EXPRESSION IN VIVO
    Mark Rich; Fiscal Year: 2000
    ..SkM1 and SkM2 are independently regulated by activity in tissue culture and neuromuscular blockade in mature muscle...
  8. NEUROTRANSMITTER RECEPTOR DYNAMICS IN VIVO
    Mohammed Akaaboune; Fiscal Year: 2002
    ..The etiology of this devastating syndrome is not known but seems analogous to the effects of neuromuscular blockade observed in the preliminary work that supports this application...
  9. A NEUROMUSCULAR BLOCKADE MONITOR USING MOTION SENSOR
    JOSEPH ORR; Fiscal Year: 1993
    There is a need to better monitor and control neuromuscular blockade, to measure whether a patient is adequately paralyzed during surgery and to facilitate mechanical ventilation in the Intensive Care Unit (ICU)...
  10. A NEUROMUSCULAR BLOCKADE MONITOR USING PIEZOELELECTRIC M
    Dwayne Westenskow; Fiscal Year: 1991
    ..The ease of application gives considerable advantage to the motion sensor over currently available techniques, making it the preferred method of monitoring neuromuscular relaxation...
  11. HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLS
    Steven Deem; Fiscal Year: 2002
    ....
  12. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2008
    ..abstract_text> ..
  13. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
    ..The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. [unreadable] [unreadable] [unreadable]..
  14. ADENOSINE DERIVATIVES AND SYNAPTIC TRANSMISSION
    EUGENE SILINSKY; Fiscal Year: 2003
    ..Indeed, fast excitatory purinergic transmission with similar properties to the neurons we study occurs in regions of the CNS associated with cholinergic synapses and with Alzheimer's disease. ..
  15. Exacerbation of Alzheimer's Disease by Nitrous Oxide
    W Kofke; Fiscal Year: 2003
    ..Moreover, observation of a protective effect may result in discovery of an easily implemented preventative drug therapy for AD. ..