obstetrical analgesia

Summary

Summary: The elimination of PAIN, without the loss of CONSCIOUSNESS, during OBSTETRIC LABOR; OBSTETRIC DELIVERY; or the POSTPARTUM PERIOD, usually through the administration of ANALGESICS.

Top Publications

  1. ncbi Ropivacaine 0.075% and bupivacaine 0.075% with fentanyl 2 microg/mL are equivalent for labor epidural analgesia
    Medge D Owen
    Department of Anesthesiology, Section of Obstetric Anesthesia, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 94:179-83, table of contents. 2002
  2. ncbi Childbirth experiences in Australia of women born in Turkey, Vietnam, and Australia
    Helen McLachlan
    Clinical School of Midwifery and Neonatal Nursing Studies, School of Nursing and Midwifery, La Trobe University, Melbourne, Victoria, Australia
    Birth 32:272-82. 2005
  3. pmc More in hope than expectation: a systematic review of women's expectations and experience of pain relief in labour
    Joanne E Lally
    Institute of Health and Society, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    BMC Med 6:7. 2008
  4. ncbi Regional anesthesia and analgesia for labor and delivery
    Holger K Eltzschig
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02115, USA
    N Engl J Med 348:319-32. 2003
  5. ncbi Obstetric pain relief and its association with remembrance of labor pain at two months and one year after birth
    Ulla Waldenström
    Department of Nursing, Karolinska Institutet, Stockholm, Sweden
    J Psychosom Obstet Gynaecol 27:147-56. 2006
  6. ncbi Background infusion is not beneficial during labor patient-controlled analgesia with 0.1% ropivacaine plus 0.5 microg/ml sufentanil
    Emmanuel Boselli
    Service d Anesthesie Reanimation, Hotel Dieu, Lyon, France
    Anesthesiology 100:968-72. 2004
  7. ncbi Comparison of patient-controlled epidural bolus administration of 0.1% ropivacaine and 0.1% levobupivacaine, both with 0.0002% fentanyl, for analgesia during labour
    N L Purdie
    University Department of Anaesthesia, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK
    Anaesthesia 59:133-7. 2004
  8. ncbi A multicenter, randomized, controlled trial comparing bupivacaine with ropivacaine for labor analgesia
    Stephen H Halpern
    Department of Anaesthesia, Sunnybrook and Women s Health Sciences Centre, Women s College Campus, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 98:1431-5. 2003
  9. ncbi Patient-controlled epidural analgesia versus continuous infusion for labour analgesia: a meta-analysis
    M van der Vyver
    Department of Anaesthesia, University of Stellenbosch, Tygerberg Academic Hospital, Private Bag 3, Tygervallei 7505, Western Cape, South Africa
    Br J Anaesth 89:459-65. 2002
  10. ncbi Knowledge and decision-making for labour analgesia of Australian primiparous women
    Camille H Raynes-Greenow
    Centre for Perinatal Health Services Research, QEII Building D02 University of Sydney, NSW 2006, Australia
    Midwifery 23:139-45. 2007

Research Grants

Detail Information

Publications218 found, 100 shown here

  1. ncbi Ropivacaine 0.075% and bupivacaine 0.075% with fentanyl 2 microg/mL are equivalent for labor epidural analgesia
    Medge D Owen
    Department of Anesthesiology, Section of Obstetric Anesthesia, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 94:179-83, table of contents. 2002
    ..We conclude that 0.075% ropivacaine and bupivacaine, with fentanyl, are equally effective for labor analgesia using the patient-controlled epidural analgesia technique...
  2. ncbi Childbirth experiences in Australia of women born in Turkey, Vietnam, and Australia
    Helen McLachlan
    Clinical School of Midwifery and Neonatal Nursing Studies, School of Nursing and Midwifery, La Trobe University, Melbourne, Victoria, Australia
    Birth 32:272-82. 2005
    ..The aim of this study was to investigate experiences of childbirth, including recollection of pain and use of pain relief, in women born in Vietnam, Turkey, and Australia who gave birth in Victoria, Australia...
  3. pmc More in hope than expectation: a systematic review of women's expectations and experience of pain relief in labour
    Joanne E Lally
    Institute of Health and Society, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    BMC Med 6:7. 2008
    ..Our aim was to systematically review the empirical literature on women's expectations and experiences of pain and pain relief during labour, as well as their involvement in the decision-making process...
  4. ncbi Regional anesthesia and analgesia for labor and delivery
    Holger K Eltzschig
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02115, USA
    N Engl J Med 348:319-32. 2003
  5. ncbi Obstetric pain relief and its association with remembrance of labor pain at two months and one year after birth
    Ulla Waldenström
    Department of Nursing, Karolinska Institutet, Stockholm, Sweden
    J Psychosom Obstet Gynaecol 27:147-56. 2006
    ..Possible explanations of these findings are discussed...
  6. ncbi Background infusion is not beneficial during labor patient-controlled analgesia with 0.1% ropivacaine plus 0.5 microg/ml sufentanil
    Emmanuel Boselli
    Service d Anesthesie Reanimation, Hotel Dieu, Lyon, France
    Anesthesiology 100:968-72. 2004
    ....
  7. ncbi Comparison of patient-controlled epidural bolus administration of 0.1% ropivacaine and 0.1% levobupivacaine, both with 0.0002% fentanyl, for analgesia during labour
    N L Purdie
    University Department of Anaesthesia, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK
    Anaesthesia 59:133-7. 2004
    ..We conclude that 0.1% ropivacaine with 0.0002% fentanyl and 0.1% levobupivacaine with 0.0002% fentanyl are clinically indistinguishable for labour analgesia and appear pharmacologically equipotent when using PCEA...
  8. ncbi A multicenter, randomized, controlled trial comparing bupivacaine with ropivacaine for labor analgesia
    Stephen H Halpern
    Department of Anaesthesia, Sunnybrook and Women s Health Sciences Centre, Women s College Campus, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 98:1431-5. 2003
    ..The purpose of this study was to determine if there is a difference in these outcomes when a low concentration of patient-controlled epidural bupivacaine combined with fentanyl is compared with ropivacaine combined with fentanyl...
  9. ncbi Patient-controlled epidural analgesia versus continuous infusion for labour analgesia: a meta-analysis
    M van der Vyver
    Department of Anaesthesia, University of Stellenbosch, Tygerberg Academic Hospital, Private Bag 3, Tygervallei 7505, Western Cape, South Africa
    Br J Anaesth 89:459-65. 2002
    ..There have been many studies performed that have compared the efficacy of PCEA with continuous epidural infusion (CEI). The purpose of this systematic review is to compare the efficacy and safety of PCEA and CEI...
  10. ncbi Knowledge and decision-making for labour analgesia of Australian primiparous women
    Camille H Raynes-Greenow
    Centre for Perinatal Health Services Research, QEII Building D02 University of Sydney, NSW 2006, Australia
    Midwifery 23:139-45. 2007
    ..to assess and investigate knowledge of labour pain management options and decision-making among primiparous women...
  11. ncbi The effects of epidural analgesia on labor, maternal, and neonatal outcomes: a systematic review
    Barbara L Leighton
    Department of Anesthesiology, Weill Medical College of Cornell University, New York, NY, USA
    Am J Obstet Gynecol 186:S69-77. 2002
    ..Epidural use and urinary incontinence are associated immediately postpartum but not at 3 or 12 months. The mechanisms of these unintended effects need to be determined to improve epidural labor analgesia...
  12. ncbi Nitrous oxide for relief of labor pain: a systematic review
    Mark A Rosen
    Department of Anesthesia and Perioperative Care and Obstetrics, University of California, San Francisco, 94143 0648, USA
    Am J Obstet Gynecol 186:S110-26. 2002
    ..Nitrous oxide is not a potent labor analgesic, but it is safe for parturient women, their newborns, and health care workers in attendance during its administration. It appears to provide adequately effective analgesia for many women...
  13. ncbi Nonpharmacologic relief of pain during labor: systematic reviews of five methods
    Penny P Simkin
    Department of Family Medicine, University of Washington, Seattle 98112, USA
    Am J Obstet Gynecol 186:S131-59. 2002
    ..Additional well-designed studies are warranted to further clarify their effect and to evaluate their cost effectiveness...
  14. ncbi Decision making in laboring women: ethical issues for perinatal nurses
    Troy Carlton
    University of Colorado School of Nursing, Denver, USA
    J Perinat Neonatal Nurs 19:145-54. 2005
    ..Ethical principles such as autonomy, veracity, beneficence, informed consent, standard of best interest, and obligations should be applied when caring for laboring women, framed by the ethics of caring...
  15. ncbi Comparison of combined spinal-epidural and low dose epidural for labour analgesia
    D L Hepner
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Can J Anaesth 47:232-6. 2000
    ..To compare the combined spinal-epidural (CSE) technique with the epidural technique with regard to time to initiate and manage, motor block, onset of analgesia and satisfaction during labour...
  16. ncbi Assessment of the effect upon maternal knowledge of an information leaflet about pain relief in labour
    A Stewart
    Magill Department of Anaesthesia, Intensive Care and Pain Management, Chelsea and Westminster Hospital, London, UK
    Anaesthesia 58:1015-9. 2003
    ....
  17. pmc Genetic variability of the mu-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women
    Ruth Landau
    Department of Anesthesia, University Hospital of Geneva, Geneva, Switzerland
    Pain 139:5-14. 2008
    ..These findings for intrathecal fentanyl pharmacogenetics may have implications for patients receiving opioids in other settings...
  18. ncbi A longitudinal study of women's memory of labour pain--from 2 months to 5 years after the birth
    U Waldenström
    Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    BJOG 116:577-83. 2009
    ..To investigate the memory of labour pain at 2 months, 1 year and 5 years after childbirth and its association with the use of epidural analgesia and overall evaluation of childbirth...
  19. ncbi Intrathecal sufentanil and fetal heart rate abnormalities: a double-blind, double placebo-controlled trial comparing two forms of combined spinal epidural analgesia with epidural analgesia in labor
    M van de Velde
    Department of Anesthesiology, University Hospitals Gasthuisberg, Katholieke Universiteit Leuven, Herestraat, Belgium
    Anesth Analg 98:1153-9, table of contents. 2004
    ..The present data corroborate previous recommendations of caution when performing CSE using a large dose (7.5 microg or more) of spinal sufentanil because of the risk of uterine hyperactivity and FHR abnormalities...
  20. ncbi Automated regular boluses for epidural analgesia: a comparison with continuous infusion
    Y Lim
    Department of Anesthesia, Obstetrics and Gynecology, KK Women s and Children s Hospital, Singapore
    Int J Obstet Anesth 14:305-9. 2005
    ..In this randomized, double-blinded study, we compared the analgesic efficacy of two drug delivery systems: regular intermittent epidural boluses and continuous epidural infusion and assessed the incidence of breakthrough pain after CSE...
  21. ncbi Incisional and epidural analgesia after caesarean delivery: a prospective, placebo-controlled, randomised clinical study
    P O Ranta
    Department of Anaesthesiology and Intensive Care, Oulu University, Finland
    Int J Obstet Anesth 15:189-94. 2006
    ..This study evaluated efficacy, safety and patient satisfaction with incisional analgesia with a subfascial catheter compared to epidural analgesia for pain relief following caesarean section...
  22. ncbi The effect of intrathecal epinephrine on epidural infused analgesics during labor
    Toshiyuki Okutomi
    Departments of Anesthesiology, Kitasato University School of Medicine, Kanagawa, Japan
    Reg Anesth Pain Med 28:108-12. 2003
    ..In this study, we tested the hypothesis that the addition of intrathecal epinephrine would lessen the requirement for a rescue dose of epidural analgesia during labor...
  23. ncbi Local anesthetic requirements are greater in dystocia than in normal labor
    Moeen K Panni
    Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
    Anesthesiology 98:957-63. 2003
    ..In this article, the authors report a prospective study determining the MLAC of bupivacaine in early labor of parturients who eventually delivered either vaginally or via cesarean section...
  24. ncbi Comparison of three modes of patient-controlled epidural analgesia during labour
    S M Siddik-Sayyid
    American University of Beirut, Department of Anesthesiology, Beirut, Lebanon
    Eur J Anaesthesiol 22:30-4. 2005
    ..This study compares three modes of patient-controlled epidural analgesia in parturients during labour...
  25. ncbi Patient-controlled epidural analgesia: the role of epidural fentanyl in peripartum urinary retention
    S Evron
    Obstetric Anesthesia Unit, Department of Anesthesia and Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, Holon
    Int J Obstet Anesth 15:206-11. 2006
    ..The effect of low-dose epidural opioid on bladder function remains unclear. We tested the hypothesis that adding low-dose fentanyl to epidural ropivacaine for patient-controlled labor analgesia does not promote urinary retention...
  26. ncbi Risk factors for failure to extend labor epidural analgesia to epidural anesthesia for Cesarean section
    S Orbach-Zinger
    Department of Anesthesiology, Rabin Medical Center Beilinson Campus, Petach Tiqva 49100, Israel
    Acta Anaesthesiol Scand 50:793-7. 2006
    ..To identify parturients at risk of inability to extend labor epidural analgesia in whom alternative methods of anesthesia should be considered for Cesarean section (CS)...
  27. ncbi [Comparison of intrathecal fentanyl and bupivacaine in combined spinal-epidural obstetric analgesia]
    J M Marcos Vidal
    Servicio de Anestesiologia y Reanimacion, Hospital de Leon, Leon
    Rev Esp Anestesiol Reanim 55:341-7. 2008
    ..To compare intrathecal injection of the opioid fentanyl to injection of bupivacaine, in terms of their effect of labour in the context within the combined spinal-epidural analgesia...
  28. ncbi Comparison of maternal and neonatal outcomes with epidural bupivacaine plus fentanyl and ropivacaine plus fentanyl for labor analgesia
    D Bolukbasi
    Department of Anesthesiology, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey
    Int J Obstet Anesth 14:288-93. 2005
    ..We aimed to compare the efficacy and side effects of epidural bupivacaine plus fentanyl and ropivacaine plus fentanyl at low concentrations...
  29. ncbi "Ultra-light" patient-controlled epidural analgesia during labor: effects of varying regimens on analgesia and physician workload
    B Carvalho
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    Int J Obstet Anesth 14:223-9. 2005
    ..This study evaluated several regimens for "ultra-light" (0.125%) PCEA with basal continuous infusion (CI) in labor with goals of minimizing physician interventions while providing good analgesia...
  30. ncbi Patient-controlled epidural analgesia for labor pain: effect on labor, delivery and neonatal outcome of 0.125% bupivacaine vs 0.2% ropivacaine
    Shmuel Evron
    Obstetric Anesthesia Unit, Edith Wolfson Medical Center, Holon, Israel
    Int J Obstet Anesth 13:5-10. 2004
    ..Ropivacaine 0.2% was equianalgesic with 0.125% bupivacaine, but produced less motor block (P < 0.0001). There were no significant differences, however, in duration of labor, delivery type or neonatal outcome...
  31. ncbi Extending low-dose epidural analgesia for emergency Caesarean section using ropivacaine 0.75%
    R D Sanders
    Magill Department of Anaesthesia, Intensive Care and Pain Management, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK
    Anaesthesia 59:988-92. 2004
    ..Time to reach T4 for loss of cold sensation was similar in both groups, although analgesic supplementation was required less often in the ropivacaine group than in the bupivacaine group (2/23 vs. 9/21; p = 0.01)...
  32. ncbi A multicenter randomized controlled trial comparing patient-controlled epidural with intravenous analgesia for pain relief in labor
    Stephen H Halpern
    Department of Anesthesia, Sunnybrook and Women s College Health Sciences Centre, 76 Grenville Street, Toronto, Ontario, M5S 1B2 Canada
    Anesth Analg 99:1532-8; table of contents. 2004
    ..These observations support the hypothesis that PCEA does not result in an increased incidence of obstetrical intervention compared with PCIA. PCEA provides superior analgesia and less maternal and neonatal sedation compared with PCIA...
  33. ncbi Change from continuous epidural infusion to patient-controlled epidural analgesia on the labour ward of a large district general hospital
    C R Dunstan
    Int J Obstet Anesth 16:93-4. 2007
  34. ncbi Epidural bupivacaine with sufentanil or fentanyl during labour: a randomized, double-blind study
    O K Rolfseng
    Trondheim University Hospital, Department of Anaesthesiology, Norway
    Eur J Anaesthesiol 19:812-8. 2002
    ..The study compared these opioids at equianalgesic doses in terms of analgesia, onset time and side-effects...
  35. ncbi 0.2% Ropivacaine and levobupivacaine provide equally effective epidural labour analgesia
    Mia Supandji
    Department of Anesthesia O and G, KK Women and Children Hospital, 100 Bukit Timah Road, Singapore
    Can J Anaesth 51:918-22. 2004
    ..To compare the duration of epidural analgesia induced by levobupivacaine and ropivacaine at clinically relevant doses...
  36. ncbi Epidural anaesthesia for pain relief in labour
    P Zuokumor
    Eur J Anaesthesiol 20:674-5; author reply 675-6. 2003
  37. ncbi Bupivacaine with meperidine versus bupivacaine with fentanyl for continuous epidural labor analgesia
    Islam M Massad
    Department of General Surgery, Anesthesia and Intensive Care, University of Jordan, Jordan University Hospital, PO Box 13046, Amman, Jordan
    Saudi Med J 28:904-8. 2007
    ..To compare the efficacy of bupivacaine-meperidine and bupivacaine-fentanyl mixtures when continuously infused epidurally to relief the labor pain...
  38. ncbi [Clinical effects and pharmacokinetics of ropivacaine and bupivacaine for epidural analgesia during labor]
    L Cánovas Martínez
    Servicio de Anestesiologia, Complexo Hospitalario Ourense
    Rev Esp Anestesiol Reanim 51:128-32. 2004
    ..To compare the analgesic efficacy, pharmacokinetics and histamine release of ropivacaine and bupivacaine with fentanyl in continuous epidural perfusion during labor and childbirth...
  39. ncbi Epidural infusions of ropivacaine and bupivacaine for labor analgesia: a randomized, double-blind study of obstetric outcome
    Bee B Lee
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China
    Anesth Analg 98:1145-52, table of contents. 2004
    ..8% (95% confidence interval, 54.4%-68.8%) in the ropivacaine group and 58.4% (95% confidence interval, 50.9%-65.5%) in the bupivacaine group (P = 0.72)...
  40. ncbi The effect of epidural analgesia in labour on maternal respiratory function
    B S von Ungern-Sternberg
    Department of Anaesthesia, University of Basel Kantonsspital, CH 4031 Basel, Switzerland
    Anaesthesia 59:350-3. 2004
    ..001); forced expiratory volume in 1 s 5.5 (1.7-8.6 [-14-28])% (p < 0.001); and peak expiratory flow rate 2.3 (-1.6-5.8 [-18-16])% (p = 0.01)). We conclude that epidural analgesia for labour significantly improved respiratory function...
  41. ncbi Severe persistent fetal bradycardia following subarachnoid administration of fentanyl and bupivacaine for induction of a combined spinal-epidural analgesia for labor pain
    Krzysztof M Kuczkowski
    J Clin Anesth 16:78-9. 2004
  42. ncbi Perispinal analgesia for labour followed by patient-controlled infusion with bupivacaine and sufentanil: combined spinal-epidural vs. epidural analgesia alone
    L Vernis
    University Hospital, Department of Anaesthesia and Intensive Care, CHU de Clermont Ferrand, France
    Eur J Anaesthesiol 21:186-92. 2004
    ..Combined spinal-epidural is an alternative technique to epidural analgesia for labour, but its benefits are not clearly identified...
  43. ncbi A multicentre trial comparing different concentrations of ropivacaine plus sufentanil with bupivacaine plus sufentanil for patient-controlled epidural analgesia in labour
    W Gogarten
    Universitatsklinikum Munster, Department of Anaesthesiology and Intensive Care, Germany
    Eur J Anaesthesiol 21:38-45. 2004
    ..To determine the optimal concentration of ropivacaine for bolus-only patient-controlled epidural labour analgesia, three different doses of ropivacaine were evaluated in comparison with bupivacaine in a double-blinded multicentre study...
  44. pmc Rates of caesarean section and instrumental vaginal delivery in nulliparous women after low concentration epidural infusions or opioid analgesia: systematic review
    E H C Liu
    Department of Anaesthesia, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    BMJ 328:1410. 2004
    ..To compare the effects of low concentration epidural infusions of bupivacaine with parenteral opioid analgesia on rates of caesarean section and instrumental vaginal delivery in nulliparous women...
  45. ncbi Epidural for labour analgesia--bupivacaine + fentanyl vs bupivacaine + fentanyl + epinephrine
    Sunanda Gupta
    RNT Medical College, Udaipur, Rajasthan, India
    Middle East J Anaesthesiol 18:611-22. 2005
    ..To conclude, the addition of epidural epinephrine (1:600,000) to bupivacaine and fentanyl does not affect the duration or quantity of labour analgesia...
  46. ncbi Patient-controlled epidural technique improves analgesia for labor but increases cesarean delivery rate compared with the intermittent bolus technique
    P Halonen
    Department of Anesthesia and Intensive Care, Helsinki University Central Hospital, Helsinki, Finland
    Acta Anaesthesiol Scand 48:732-7. 2004
    ..We tested the hypothesis that patient-controlled epidural analgesia for labor (PCEA) provides better analgesia and satisfaction than the intermittent bolus technique (bolus) without affecting the mode of delivery...
  47. ncbi A comparison of duration of analgesia of intrathecal 2.5 mg of bupivacaine, ropivacaine, and levobupivacaine in combined spinal epidural analgesia for patients in labor
    Yvonne Lim
    Department of Anesthesia, KK Women s and Children s Hospital, 100 Bukit Timah Road, Singapore 229899, Republic of Singapore
    Anesth Analg 98:235-9, table of contents. 2004
    ..05). The profile of the other side effects was indistinguishable between the groups. With the current regimen, IT bupivacaine produced the longest duration of labor analgesia...
  48. ncbi Automated intermittent epidural boluses improve analgesia induced by intrathecal fentanyl during labour
    Sebastian M H Chua
    Department of Anaesthesia, Singapore General Hospital, Singapore
    Can J Anaesth 51:581-5. 2004
    ..We compared the efficacy of epidural continual intermittent boluses (CIB) with a continuous epidural infusion (CEI) in prolonging labour analgesia induced by the combined spinal epidural (CSE) technique...
  49. ncbi Ropivacaine and fentanyl concentrations in patient-controlled epidural analgesia during labor: a volume-range study
    Jean Marc Bernard
    Departement d Anesthesie Reanimation, Polyclinique Jean Villar, Bruges Bordeaux, France
    Anesth Analg 97:1800-7. 2003
    ..These results suggest that the effectiveness of PCEA is dependent on drug mass rather than the volume or concentration administered with each successful pump demand...
  50. ncbi The site of action of epidural fentanyl infusions in the presence of local anesthetics: a minimum local analgesic concentration infusion study in nulliparous labor
    Yehuda Ginosar
    Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University School of Medicine, Jerusalem, Israel
    Anesth Analg 97:1439-45. 2003
    ..This marked increase in potency for the epidural route is highly suggestive for a predominantly spinal mechanism of action for infused epidural fentanyl under the conditions of this study...
  51. ncbi High quality labour analgesia using small gauge epidural needles and catheters
    Pamela J Angle
    Department of Anesthesia, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Ontario M5S 1B2, Canada
    Can J Anaesth 53:263-7. 2006
    ..We report the first study to examine the feasibility of using small G Tuohy needles and 23 G catheters for labour analgesia...
  52. ncbi Cesarean section in a patient with familial cardiomyopathy and a cardioverter-defibrillator
    Don A Frost
    Department of General Anesthesiology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, E 31, Cleveland, Ohio 44195, USA
    Can J Anaesth 53:478-81. 2006
    ..To describe the impact of maternal automatic implantable cardioverter-defibrillator (AICD) therapy on pregnancy outcome, and discuss the clinical rationale for regional anesthesia in parturients with AICDs...
  53. ncbi [Maternal postures and epidural analgesia during labour]
    A S Ducloy-Bouthors
    clinique d anesthésie réanimation, Maternité Jeanne de Flandre, CHRU de Lille, 2, Avenue Oscar Lambret, 59037 Lille Cedex, France
    Ann Fr Anesth Reanim 25:605-8. 2006
    ..We conclude that, for the three hip-flexed postures tested, position does not influence local anesthetic spread or symmetry of analgesia after induction of obstetric epidural anaesthesia...
  54. ncbi Chloroprocaine may not affect epidural morphine for postcesarean delivery analgesia
    Philip E Hess
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Clin Anesth 18:29-33. 2006
    ..The purpose of this study is to assess the independent effect of epidural chloroprocaine on morphine used for pain relief after cesarean delivery...
  55. ncbi Ropivacaine 0.15% plus sufentanil 0.5 microg/mL and ropivacaine 0.10% plus sufentanil 0.5 microg/mL are equivalent for patient-controlled epidural analgesia during labor
    Emmanuel Boselli
    Service d Anesthesie Reanimation, Hotel Dieu, 1 Place de l Hopital, 69288 Lyon Cedex 02, France
    Anesth Analg 96:1173-7, table of contents. 2003
    ..However, this reduction in local anesthetic is not associated with a decrease in the incidence of motor block, side effects, or instrumental deliveries...
  56. ncbi Intrathecal morphine reduces breakthrough pain during labour epidural analgesia
    A Vasudevan
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Br J Anaesth 98:241-5. 2007
    ..We tested the hypothesis that a small dose of intrathecal morphine would reduce breakthrough pain...
  57. ncbi Intrathecal ropivacaine or bupivacaine with fentanyl for labour
    D Hughes
    Department of Anaesthetics, The Ulster Hospital, Dundonald, Belfast, UK
    Br J Anaesth 87:733-7. 2001
    ..5 mg in combination with fentanyl 0.025 mg as part of a CSE technique provides rapid and safe analgesia for labour as effective as that achieved with bupivacaine 2.5 mg and with significantly less motor block...
  58. ncbi Extending low-dose epidural analgesia in labour for emergency Caesarean section - a comparison of levobupivacaine with or without fentanyl
    S Malhotra
    Magill Department of Anaesthesia, Chelsea and Westminster Hospital, 369 Fullham Road, London SW10 9NH, UK
    Anaesthesia 62:667-71. 2007
    ..Power analysis suggested the same conclusion even had the study proceeded to completion...
  59. ncbi Local anesthetics and mode of delivery: bupivacaine versus ropivacaine versus levobupivacaine
    Yaakov Beilin
    Department of Anesthesiology, The Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Anesth Analg 105:756-63. 2007
    ..In this study, we sought to determine if there is a difference in mode of delivery among parturients who receive epidural bupivacaine, ropivacaine, or levobupivacaine...
  60. ncbi Maternal analgesia during labor disturbs newborn behavior: effects on breastfeeding, temperature, and crying
    A B Ransjö-Arvidson
    Division of Reproductive and Perinatal Health Care at the Department of Women and Child Health, Karolinska Institutet, Stockholm, Sweden
    Birth 28:5-12. 2001
    ....
  61. ncbi Ropivacaine 1 mg/ml, plus fentanyl 2 microg/ml for epidural analgesia during labour. Is mode of administration important?
    J P Smedvig
    Department of Anaesthesia and Intensive Care, Rogaland Central Hospital, Stavanger, N 4068 Norway
    Acta Anaesthesiol Scand 45:595-9. 2001
    ..We hypothesised that the use of a very low concentration technique (ropivacaine/fentanyl) might result in excessive dosing in the PCEA group, more motor blockade and a negative impact on spontaneous delivery rate...
  62. ncbi Comparison of fentanyl and sufentanil in combination with bupivacaine for patient-controlled epidural analgesia during labor
    H Le Guen
    Department of Anesthesiology and Surgical Intensive Care 2, , Rennes, France
    J Clin Anesth 13:98-102. 2001
    ..No difference was observed in Apgar scores. CONCLUSIONS: Sufentanil is preferable to fentanyl during bupivacaine PCEA as there is less incidence of motor blockade and pruritus...
  63. ncbi [Comparison of ropivacaine and bupivacaine for epidural analgesia during labor]
    P Sanchez-Conde
    Servicio de Anestesiologia, Reanimación y Terapéutica del DolorHospital Clínico Universitario de Salamanca Salamanca
    Rev Esp Anestesiol Reanim 48:199-203. 2001
    ..To compare the analgesic efficacy and level of motor block using two local anesthetics, ropivacaine and bupivacaine, during labor...
  64. ncbi A randomized trial of intrapartum analgesia in women with severe preeclampsia
    Barbara B Head
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7333, USA
    Obstet Gynecol 99:452-7. 2002
    ..To estimate whether the cesarean delivery rate differs between women with severe preeclampsia who receive intrapartum epidural analgesia versus patient-controlled intravenous opioid analgesia...
  65. ncbi Cost-effectiveness of analgesia after Caesarean section. A comparison of intrathecal morphine and epidural PCA
    M Vercauteren
    Department of Anesthesia, University Hospital Antwerp, Edegem, Belgium
    Acta Anaesthesiol Scand 46:85-9. 2002
    ..Patient-controlled analgesia (PCA) techniques and intrathecal morphine are the most widely used treatments for post-Caesarean section pain. However these methods have not been compared with respect to analgesic quality and cost differences...
  66. ncbi The addition of morphine prolongs fentanyl-bupivacaine spinal analgesia for the relief of labor pain
    H M Yeh
    Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan
    Anesth Analg 92:665-8. 2001
    ..IMPLICATIONS: The addition of morphine (150 microg) to intrathecal fentanyl (25 microg) and bupivacaine (2.5 mg) prolongs the duration of labor analgesia duration without increasing adverse effects...
  67. ncbi Efficacy of ropivacaine, bupivacaine, and levobupivacaine for labor epidural analgesia
    Neera Sah
    Department of Anesthesiology, Magee Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Anesth 19:214-7. 2007
    ..To compare analgesic efficacy and intensity of motor block with continuous infusions of ropivacaine, bupivacaine, and levobupivacaine in combination with fentanyl for labor epidural analgesia...
  68. ncbi Epinephrine is not a useful addition to intrathecal fentanyl or fentanyl-bupivacaine for labor analgesia
    Stephanie R Goodman
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Reg Anesth Pain Med 27:374-9. 2002
    ..Intrathecal fentanyl provides effective labor analgesia for a limited time with frequent side effects. We evaluated the effects of adding epinephrine to intrathecal fentanyl with and without bupivacaine...
  69. ncbi Comparison of bupivacaine 0.2% and ropivacaine 0.2% combined with fentanyl for epidural analgesia during labour
    I Asik
    University of Ankara, Department of Anesthesiology and Intensive Care, Faculty of Medicine, Turkey
    Eur J Anaesthesiol 19:263-70. 2002
    ..The purpose of the study was to evaluate the effects of epidural bupivacaine 0.2% compared with ropivacaine 0.2% combined with fentanyl for the initiation and maintenance of analgesia during labour and delivery...
  70. ncbi Addition of bupivacaine 1.25 mg to fentanyl confers no advantage over fentanyl alone for intrathecal analgesia in early labour
    Evangeline H L Lim
    Department of Anaesthesia, KK Women s and Children s Hospital, Singapore
    Can J Anaesth 49:57-61. 2002
    ..25 mg of bupivacaine to intrathecal fentanyl on the duration of analgesia in an Asian population and b) to examine if the baricity of the local anesthetic at this dose has any bearing on the duration and quality of block...
  71. ncbi Parturient-controlled epidural analgesia during labour: bupivacaine vs. ropivacaine
    N P Chua
    Department of Anaesthesia, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229 899
    Anaesthesia 56:1169-73. 2001
    ..No difference in maternal or fetal outcome was detected. We conclude that, at a concentration of 0.125%, ropivacaine and bupivacaine were equally effective when self-administered using this patient-controlled regimen...
  72. ncbi A comparison of three doses of sufentanil in combination with bupivacaine-adrenaline in continuous epidural analgesia during labour
    S L Eriksson
    Department of Anaesthesiology and Intensive Care, , Stockholm, Sweden
    Acta Anaesthesiol Scand 44:919-23. 2000
    ..CONCLUSION: We found no difference in the analgesic effect between three different concentrations of sufentanil. We conclude that the lowest dose may be used. This should decrease the risk of adverse effects on mother and child...
  73. ncbi Ropivacaine 2 mg/mL vs. bupivacaine 1.25 mg/mL with sufentanil using patient-controlled epidural analgesia in labour
    K Hofmann-Kiefer
    Klinik für Anaesthesiologie der Ludwig Maximilians Universität München, Klinikum Innenstadt, Munich, Germany
    Acta Anaesthesiol Scand 46:316-21. 2002
    ..6. In the current study we compared ropivacaine and bupivacaine in a PCEA system (combined with sufentanil) taking this potency ratio into account but administering drug doses providing sufficient analgesia for all stages of labour...
  74. ncbi A comparison of epidural infusions in the combined spinal/epidural technique for labor analgesia
    Yaakov Beilin
    Department of Anesthesiology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Anesth Analg 94:927-32, table of contents. 2002
    ..We conclude that all the bupivacaine-based infusions we tested maintained the analgesia from subarachnoid medication longer than saline, with the longest duration, but the most motor block, from bupivacaine 0.125%...
  75. ncbi Minimum local analgesic dose of intrathecal bupivacaine in labor and the effect of intrathecal fentanyl
    G M Stocks
    Department of Anaesthetics, Royal Free Hospital, London, United Kingdom
    Anesthesiology 94:593-8; discussion 5A. 2001
    ..Analgesia in the first stage of labor can be achieved using lower doses of fentanyl, resulting in less pruritus but with a shortening of duration of action...
  76. ncbi [Epidural obstetric analgesia, maternal fever and neonatal wellness parameters]
    J Fernández-Guisasola
    Area de Anestesia, Reanimación y Cuidados Críticos, Unidad de Anestesia Reanimación, Fundacion Hospital Alcorcon, Madrid
    Rev Esp Anestesiol Reanim 52:217-21. 2005
    ....
  77. ncbi Obstetric analgesia and anaesthesia in women with inherited bleeding disorders
    Claudia Chi
    Department of Obstetrics and Gynaecology, Royal Free Hospital, Pond Street, London, NW3 2QG, United Kingdom
    Thromb Haemost 101:1104-11. 2009
    ....
  78. ncbi Is paracervical block safe and effective? A prospective study of its association with neonatal umbilical artery pH values
    B T Levy
    Department of Family Medicine, University of Iowa, Iowa City 52242, USA
    J Fam Pract 48:778-84. 1999
    ..Paracervical blocks (PCBs) relieve labor pain, but reports of associated complications have caused many physicians to question their safety...
  79. ncbi Obstetric anesthesia - then and now
    H S Chadwick
    Department of Anesthesiology, University of Washington, Seattle, 98195, USA
    Minerva Anestesiol 71:517-20. 2005
    ..Current obstetric anesthetic practice, though quite different from what it was 30 or 40 years ago, has its roots in the priorities, techniques and teachings of Dr. John J. Bonica...
  80. ncbi Epidural analgesia for pain relief in labour and childbirth - a review with a systematic approach
    Astrid Nystedt
    Obstetrics and Gynaecology, Department of Clinical Science, Umea University, Umea, Sweden
    J Clin Nurs 13:455-66. 2004
    ..Clinical ambiguity concerning effects of epidural analgesia for pain relief in labour seems to reflect a need for evidence-based knowledge for midwives...
  81. ncbi [Combined subarachnoid-epidural technique for obstetric analgesia]
    J Fernández-Guisasola
    Unidad de Anestesia Reanimación, Fundacion Hospital Alcorcon, Madrid
    Rev Esp Anestesiol Reanim 47:207-15. 2000
    ..Because opioids are injected into the intrathecal space and because the technique is more invasive than standard epidural analgesia, the potential risk to mother and fetus increases...
  82. ncbi Comparison of intrathecal levobupivacaine with and without fentanyl in combined spinal epidural for labor analgesia
    Yvonne Lim
    Department of Anesthesia O and G, KK Women s and Children s Hospital, Singapore, Singapore
    Med Sci Monit 10:PI87-91. 2004
    ..We wished to determine if addition of IT fentanyl to IT levobupivacaine in combined spinal epidural (CSE) could prolong obstetric analgesia when epidural infusion is initiated promptly...
  83. ncbi PCEA compared to continuous epidural infusion in an ultra-low-dose regimen for labor pain relief: a randomized study
    S Ledin Eriksson
    Department of Anaesthesiology and Intensive Care, Gävle Sandviken County Hospital, Gavle, Sweden
    Acta Anaesthesiol Scand 47:1085-90. 2003
    ..Many studies have shown that the consumption of analgesic is reduced when the parturient requests her own doses. This study investigates whether this is also true when using an ultra-low-dose regimen...
  84. ncbi Effects of local anesthetics on pregnant uterine muscles
    Bilge Karsli
    Akdeniz University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Antalya, Turkey
    Pol J Pharmacol 55:51-6. 2003
    ..In conclusion, the study drugs at higher concentrations decreased contractions of myometrium, but all drugs at higher concentrations elevated the frequency...
  85. ncbi [General anesthesia with remifentanil in two cases of emergency cesarean section]
    L Santos Iglesias
    Departamento de Anestesiología y Reanimación, Hospital Universitario de Canarias, La Laguna
    Rev Esp Anestesiol Reanim 48:244-7. 2001
    ..We consider remifentanil to be safe and effective for general anesthesia for emergency cesarean delivery in patients with cardiac and/or neurological risk factors...
  86. ncbi [Obstetric analgesia in Norwegian hospitals]
    Andreas Barratt-Due
    Anestesiavdelingen, Sykehuset Asker og Baerum, Postboks 83, 1309 Rud
    Tidsskr Nor Laegeforen 125:2504-6. 2005
    ..We wanted to see if this was a general trend in Norway, and wanted to find out for what kind of labour analgesia was offered in the different labour wards...
  87. ncbi Intrathecal opioids for combined spinal-epidural analgesia during labour
    Peter DeBalli
    Division of Women s Anesthesia, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    CNS Drugs 17:889-904. 2003
    ..Ultimately, the decision to choose a CSE technique depends on the experience of the anaesthesia provider and the local availability of drugs, equipment and monitoring capabilities...
  88. ncbi [Comparison of 0.125% bupivacaine and 0.2% ropivacaine in obstetric analgesia]
    M Zackova
    Servizio di Anestesia e Rianimazione, Azienda USL Bologna Città, Ospedale Bellaria
    Minerva Anestesiol 66:643-8. 2000
    ..3% of cases. There was no Apgar score < 7 in either group. It was therefore concluded that both bupivacaine and ropivacaine offer excellent analgesia during labour and have no significant side effects on mothers or babies...
  89. ncbi How much labor is in a labor epidural? Manpower cost and reimbursement for an obstetric analgesia service in a teaching institution
    E D Bell
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 92:851-8. 2000
    ..This study defines the manpower costs of operating an OAS in a tertiary referral center and examines reimbursement for this cost...
  90. ncbi [Dural puncture in obstetric analgesia. Epidemiologic features and therapeutic management]
    A G Aya
    Département d anesthésie douleur, Hopital Caremeau, rue du Pr Debré, 30029 Nimes, France
    Ann Fr Anesth Reanim 20:757-62. 2001
    ....
  91. ncbi [Obstetric analgesia in 28 women with idiopathic thrombocytopenic purpura]
    I Ramos
    Servicio de Anestesiologia, Reanimación y Tratamiento del Dolor, Hospital del Mar, Pg Marítim, 25 29, Barcelona
    Rev Esp Anestesiol Reanim 51:378-84. 2004
    ..To assess complications arising from regional analgesia for obstetric labor and delivery in women with idiopathic thrombocytopenic purpura (ITP)...
  92. ncbi A randomized sequential allocation study to determine the minimum effective analgesic concentration of levobupivacaine and ropivacaine in patients receiving epidural analgesia for labor
    Dan Benhamou
    Departement d Anesthesie Reanimation, Hopital Antoine Beclere, Clamart, France
    Anesthesiology 99:1383-6. 2003
    ..This study was designed to determine and compare the minimum local analgesic concentrations of levobupivacaine and ropivacaine when used in epidural obstetric analgesia...
  93. ncbi [Effectiveness and tolerance of tramadol with or without an antiemetic and pethidine in obstetric analgesia]
    C Kainz
    II Universitäts Frauenklinik Wien
    Z Geburtshilfe Perinatol 196:78-82. 1992
    ..In all three groups the analgesic effect was equally good. Combination of the analgesic with the antiemetic showed no reduction of the incidence and severity of side effects...
  94. ncbi Effects on mother and fetus of epidural and combined spinal-epidural techniques for labor analgesia
    Giane Nakamura
    Faculdade de Medicina de Botucatu, UNESP, Botucatu, SP, Brazil
    Rev Assoc Med Bras 55:405-9. 2009
    ..Epidural (EA) and combined spinal-epidural (CSE) techniques have both been utilized for labor analgesia. This study compared the effects on the mother and newborn of these techniques in labor analgesia and anesthesia...
  95. ncbi Informed consent in obstetric anesthesia
    Brian M Broaddus
    Anesthesia Associates, Beaumont, Texas, USA
    Anesth Analg 112:912-5. 2011
    ..Successful navigation of the consent process requires knowledge of the guidelines and laws that govern each provider's individual jurisdiction...
  96. ncbi In vitro effects of opioids on pregnant uterine muscle
    Nurten Kayacan
    Department of Anesthesiology, Akdeniz University Medical Faculty, Antalya, Turkey
    Adv Ther 24:368-75. 2007
    ..When administered at higher concentrations, opioids may decrease contractions in pregnant rat myometrium...
  97. ncbi [Evaluation of the knowledge and attitude of obstetric patients on epidural analgesia]
    L Pirbudak
    Gaziantep Universitesi Tip Fakültesi Anesteziyoloji Anabilim Dali, Gaziantep, Turkey
    Agri 16:64-8. 2004
    ..01). As a result, considering the mother candidates' high information rate from someone who experienced EA before (60%), interest to the labour analgesia will increase as the mothers are satisfied with the results of EA...
  98. ncbi [Obstetric analgesia and anesthesia in Switzerland in 1999]
    G Zwetsch-Rast
    Departement für Anästhesie und Intensivmedizin Universität Basel, Kantonsspital und Universitätsfrauenklinik Basel, Schweiz
    Anaesthesist 51:103-9. 2002
    ..This survey investigated the common practice of obstetric analgesia and anaesthesia in Swiss hospitals and evaluated the influence of the Swiss interest group for obstetric anaesthesia...
  99. ncbi Non-nutritive sucking by infants exposed to pethidine in utero
    M Hafström
    Department of Pediatrics, University of Goteborg, Sweden
    Acta Paediatr 89:1196-200. 2000
    ..The pattern was analysed and quantified using an automatic computer-based method. The results are discussed in the context of endogenous and exogenous opiates and their effect on brain-stem rhythm generators...
  100. ncbi Lumbar spondylodiscitis caused by Propionibacterium acnes after epidural obstetric analgesia
    Joaquín Hernández-Palazón
    Department of Anesthesia, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    Anesth Analg 96:1486-8, table of contents. 2003
    ....
  101. ncbi Obstetric analgesia
    M B Stephens
    Department of Family Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Prim Care 27:203-20. 2000
    ..Continued patient-doctor communication throughout labor is essential. Patient preferences, tempered by sound medical judgement, should guide the selection of the optimal modality for pain control during labor...

Research Grants7

  1. OCT-Guided Interventions for Pain Management
    Cha Min Tang; Fiscal Year: 2007
    ..Between two and three million epidurals are performed each year in this country for obstetrical analgesia. A comparable number of epidural anesthesia procedures are performed as part of other surgical indications...
  2. PEPTIDES AS CENTRALLY OR PERIPHERALLY ACTING ANALGESICS
    Peter Schiller; Fiscal Year: 1992
    ..Placental transfer and fetal effects of the opioid peptide analogs will be determined using the chronically-instrumented pregnant sheep model...
  3. Clinical Measures to Lower Genital Tract Trauma at Birth
    Leah Albers; Fiscal Year: 2004
    ....
  4. ANESHETIC MODULATION OF NATIVE NICOTINIC RECEPTORS
    Pamela Flood; Fiscal Year: 2003
    ..The resulting information will provide understanding of the molecular mechanism underlying one of the anesthetic effects that limit anesthetic safety. ..
  5. Are Volume Standards Accurate Measures of Quality?
    Laurent Glance; Fiscal Year: 2005
    ..abstract_text> ..
  6. Beta2 adrenoceptor genotype and preterm labor
    Richard Smiley; Fiscal Year: 2009
    ..abstract_text> ..