- Placebo and opioid analgesia-- imaging a shared neuronal network
Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
Science 295:1737-40. 2002
It has been suggested that placebo analgesia involves both higher order cognitive networks and endogenous opioid systems...
- Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
Department of Anatomy and Physiology and WM Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, USA
Cell 137:1148-59. 2009
..These results demonstrate that behaviorally relevant pain modalities can be selectively regulated through the targeting of distinct subsets of primary afferent pain fibers...
- Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions
P A I N Group, Massachusetts General Hospital, McLean Hospital, and Children s Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
Discov Med 11:197-207. 2011
..Chronic pain is now considered to be a disease of the central nervous system. Since behavior (including pain or analgesia) results from activity in brain circuits through the participation of many brain regions, we suggest that ..
- Linking pain and the body: neural correlates of visually induced analgesia
Matthew R Longo
Department of Psychological Sciences, Birkbeck, University of London, London, UK
J Neurosci 32:2601-7. 2012
The visual context of seeing the body can reduce the experience of acute pain, producing a multisensory analgesia. Here we investigated the neural correlates of this "visually induced analgesia" using fMRI...
- tDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine
Alexandre F DaSilva
Headache and Orofacial Pain Effort, Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
Headache 52:1283-95. 2012
..In addition, using a high-resolution tDCS computational model, we analyzed the current flow (electric field) through brain regions associated with pain perception and modulation...
- Visually induced analgesia: seeing the body reduces pain
Matthew R Longo
Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
J Neurosci 29:12125-30. 2009
..Furthermore, these effects were specific to vision of one's own hand and were absent when viewing another person's hand. These results demonstrate a novel analgesic effect of non-informative vision of the body...
- Loss of peripheral morphine analgesia contributes to the reduced effectiveness of systemic morphine in neuropathic pain
Md Harunor Rashid
Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
J Pharmacol Exp Ther 309:380-7. 2004
..the decreased effectiveness of systemic morphine in neuropathic pain might be caused by the loss of morphine analgesia at the periphery. When given s.c. or i.t...
- Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: do conditioning stimulus painfulness, gender and personality variables matter?
Faculty of Social Welfare and Health Studies, University of Haifa, Israel
Pain 136:142-9. 2008
..the association between parameters of the conditioning stimulus, gender and personality, and the endogenous analgesia (EA) extent assessed by diffuse noxious inhibitory control (DNIC) paradigm...
- Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging
P A I N Group, Massachusetts General Hospital, McLean Hospital, and Children s Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
Discov Med 11:209-19. 2011
..An important area for future research is to image clinical ongoing pain to further our knowledge of brain function in different pain states and the effects of treatment...
- Central mechanisms of menthol-induced analgesia
Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
J Pharmacol Exp Ther 343:661-72. 2012
..These data provide molecular and cellular mechanisms by which menthol decreases neuronal excitability, therefore contributing to menthol-induced central analgesia.
- Enhanced morphine analgesia in mice lacking beta-arrestin 2
L M Bohn
Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA
Science 286:2495-8. 1999
..Moreover, they suggest that inhibition of beta-arrestin 2 function might lead to enhanced analgesic effectiveness of morphine and provide potential new avenues for the study and treatment of pain, narcotic tolerance, and dependence...
- Femoral nerve block improves analgesia outcomes after total knee arthroplasty: a meta-analysis of randomized controlled trials
James E Paul
Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
Anesthesiology 113:1144-62. 2010
Femoral nerve blockade (FNB) is a common method of analgesia for postoperative pain control after total knee arthroplasty...
- High-volume infiltration analgesia in total knee arthroplasty: a randomized, double-blind, placebo-controlled trial
L Ø Andersen
Department of Anesthesiology, Hvidovre University Hospital, Copenhagen, Denmark
Acta Anaesthesiol Scand 52:1331-5. 2008
High-volume infiltration analgesia may be effective with a low risk of side effects in hip and knee arthroplasty...
- Stress-induced analgesia
Ryan K Butler
Department of Pharmacology and Therapeutics, NCBES Neuroscience Cluster and Centre for Pain Research, National University of Ireland, Galway, University Road, Galway, Ireland
Prog Neurobiol 88:184-202. 2009
..suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that ..
- An endocannabinoid mechanism for stress-induced analgesia
Andrea G Hohmann
Neuroscience and Behavior Program, Department of Psychology, The University of Georgia, Athens, Georgia 30602 3013, USA
Nature 435:1108-12. 2005
..Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain...
- Activation of the opioidergic descending pain control system underlies placebo analgesia
Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Neuron 63:533-43. 2009
Placebo analgesia involves the endogenous opioid system, as administration of the opioid antagonist naloxone decreases placebo analgesia...
- Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients
Dennis R Kerr
Joint Orthopaedic Centre, New South Wales, Australia
Acta Orthop 79:174-83. 2008
..a multimodal technique for the control of pain following knee and hip surgery, called "local infiltration analgesia" (LIA)...
- Leukocytes in the regulation of pain and analgesia
H L Rittner
Klinik fur Anasthesiologie und Operative Intensivmedizin, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, D 12200 Berlin, Germany
J Leukoc Biol 78:1215-22. 2005
..opioid peptides and opioid receptors can lead to potent, clinically relevant inhibition of pain (analgesia). Opioid receptors are present on peripheral endings of sensory neurons...
- How prior experience shapes placebo analgesia
Department of Neuroscience, Clinical and Applied Physiology Program, University of Turin Medical School, Turin, Italy
Pain 124:126-33. 2006
Some studies indicate that placebo analgesia is stronger when pre-conditioning with effective analgesic treatments is performed, thereby suggesting that the placebo response is a learning phenomenon...
- Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain
Marwan N Baliki
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Neuron 66:149-60. 2010
..Therefore, in contrast to somatosensory pathways, which reflect sensory properties of acute noxious stimuli, NAc activity in humans encodes its predicted value and anticipates its analgesic potential on chronic pain...
- Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version
Department of Anesthesiology and Operative Intensive Care, Klinik am Eichert, Goppingen, Germany
Ger Med Sci 8:Doc02. 2010
Targeted monitoring of analgesia, sedation and delirium, as well as their appropriate management in critically ill patients is a standard of care in intensive care medicine...
- COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia
1Division of Hematology, Oncology and Transplantation, the Vascular Biology Center, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Br J Cancer 97:1523-31. 2007
..if celecoxib (a cyclooxygenase-2 (COX-2) inhibitor) prevents morphine-induced tumour growth without compromising analgesia. The effect of chronic treatment with celecoxib (by gavage) and/or morphine (subcutaneously), or PBS on tumour ..
- Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin
Department of Cellular Neurophysiology, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic
Physiol Res 57:S59-68. 2008
..desensitization of TRPV1 channels and explores to what extent they may contribute to capsaicin-induced analgesia. In view of the polymodal nature of TRPV1, we illustrate how the channels behave in their desensitized state ..
- A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia
Wendy M Knowlton
Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 33:2837-48. 2013
..Moreover, cooling-induced analgesia after nerve injury was abolished in both genotypes...
- A key role of the basal ganglia in pain and analgesia--insights gained through human functional imaging
PAIN Group, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Mol Pain 6:27. 2010
..These include the integration of motor, emotional, autonomic and cognitive responses to pain...
- Comparison of neosaxitoxin versus bupivacaine via port infiltration for postoperative analgesia following laparoscopic cholecystectomy: a randomized, double-blind trial
Alberto J Rodriguez-Navarro
Department of Surgery, Hospital Padre Hurtado, Santiago, Chile
Reg Anesth Pain Med 36:103-9. 2011
Wound infiltration with available local anesthetics generally provides analgesia for less than 8 hrs. The site 1 sodium-channel toxin neosaxitoxin (neoSTX) produced analgesia for over 24 hrs in animals and human volunteers...
- Epigenetics in pain and analgesia: an imminent research field
Pharmazentrum frankfurt ZAFES, Institute for Clinical Pharmacology, Goethe University, Theodor Stern Kai 7, Frankfurt am Main, Germany
Eur J Pain 15:11-6. 2011
..Thus, the new field of epigenetics becomes increasingly used in research and management of pain and will complement genetics. This article introduces epigenetics to pain and summarizes the current and future utility...
- Effectiveness of acute postoperative pain management: I. Evidence from published data
S J Dolin
Pain Clinic, St Richard s Hospital, Chichester PO19 4E, UK
Br J Anaesth 89:409-23. 2002
..m.) analgesia, patient controlled analgesia (PCA), and epidural analgesia.
- Treating pain with pain: supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation
Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Pain 152:428-39. 2011
..HNCS led to marked endogenous analgesia and this effect correlated positively with the perceived intensity of the tonic painful stimulus...
- Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
Anesthesiology 113:1392-405. 2010
..The sites of action and cellular mechanisms by which spinal cord stimulation reduces neuropathic pain remain unclear...
- Involvement of spinal neurotrophin-3 in electroacupuncture analgesia and inhibition of spinal glial activation in rat model of monoarthritis
Wen Li Mi
Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, China
J Pain 12:974-84. 2011
..EA) has been proven to effectively relieve pain associated with arthritis, the underlying mechanism of EA analgesia requires further investigation...
- Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids
Xian Yu Liu
Center for the Study of Itch, Washington University School of Medicine Pain Center, St Louis, MO 63110, USA
Cell 147:447-58. 2011
..essential for morphine-induced scratching (MIS), whereas the isoform MOR1 is required only for morphine-induced analgesia (MIA)...
- Immune conditions associated with CD4+ T effector-induced opioid release and analgesia
INSERM, U1043, Toulouse, France
Pain 153:485-93. 2012
..Accordingly, analgesia was inhibited by neutralizing cognate T cell receptor-mediated interaction between effector CD4(+) T lymphocytes ..
- Sedation and analgesia in German intensive care units: how is it done in reality? Results of a patient-based survey of analgesia and sedation
Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Hospital am Eichert, Eichertstrasse 3, 73035 Göppingen, Germany
Intensive Care Med 32:1137-42. 2006
This study carried out the first patient-oriented survey on the practice of analgesia and sedation in German intensive care units, examining whether the goals of early spontaneous breathing and awake, cooperative patients are achieved.
- Alarm pheromone induces stress analgesia via an opioid system in the honeybee
Department of Biological Sciences, FCEyN, Universidad de Buenos Aires, Argentina
Physiol Behav 63:75-80. 1997
..The resulting stress-induced analgesia in the defender bee would reduce its probability of withdrawal thus increasing its efficiency against enemies.
- Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia
INSERM E9904, U766, Facultes de Medecine et de Pharmacie, 28, Place Henri Dunant, B P 38, F 63001 Clermont Ferrand Cedex 01, France
Pain 139:190-200. 2008
..We therefore propose that acetaminophen-induced analgesia could involve the following sequence: (1) FAAH-dependent metabolism of acetaminophen into AM404; (2) indirect ..
- Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors
Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Proc Natl Acad Sci U S A 103:17880-4. 2006
..Our findings not only suggest a molecular mechanism for the treatment of neuropathic pain but also demonstrate the involvement of alpha9alpha10 nAChRs in the pathophysiology of peripheral nerve injury...
- Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data
Suellen M Walker
Portex Unit Pain Research, UCL Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
Anesth Analg 115:638-62. 2012
..Opioids or clonidine improves analgesia when added to perioperative epidural infusions; analgesia is significantly prolonged by the addition of ..
- Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance
Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Trends Pharmacol Sci 27:324-9. 2006
..Experiments in animals show that MOP-receptor-mediated spinal analgesia is enhanced and morphine tolerance does not develop when DOP receptor functions are pharmacologically or ..
- Sedation and analgesia in the mechanically ventilated patient
Shruti B Patel
Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Illinois, USA
Am J Respir Crit Care Med 185:486-97. 2012
Sedation and analgesia are important components of care for the mechanically ventilated patient in the intensive care unit (ICU)...
- I-SAVE study: impact of sedation, analgesia, and delirium protocols evaluated in the intensive care unit: an economic evaluation
Don Kelena Awissi
Pharmacy Department, Maisonneuve Rosemont Hospital, Montreal, Quebec, Canada
Ann Pharmacother 46:21-8. 2012
..Intensive care units (ICUs) account for considerable health care costs. Adequate pain and sedation management is important to clinical care...
- Use of intrathecal midazolam to improve perioperative analgesia: a meta-analysis
K M Ho
Intensive Care Unit, Royal Perth Hospital, Perth, Western Australia, Australia
Anaesth Intensive Care 36:365-73. 2008
..50, 95% confidence interval [CI] 0.27 to 0.90, P=0.02; I2=4%) and delayed the time to request for rescue analgesia (weighted-mean-difference=98.7 min, 95% CI: 76.1 to 121.4, P<0.00001; I2=98.5%)...
- Placebo analgesia affects the behavioral despair tests and hormonal secretions in mice
Jian You Guo
Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 10A Datun Road, Chaoyang District, Beijing 100101, People s Republic of China
Psychopharmacology (Berl) 217:83-90. 2011
..2011) showed that, in human subjects, the placebo effect can be transferred from one domain to the other, namely from pain to emotion...
- Daily repeated magnetic field shielding induces analgesia in CD-1 mice
Frank S Prato
Department of Nuclear Medicine, Bioelectromagnetics, Lawson Health Research Institute, St Joseph s Health Care, London, Ontario N6A 4V2, Canada
Bioelectromagnetics 26:109-17. 2005
..observed that a single exposure of mice to a magnetically shielded environment can attenuate opioid induced analgesia. Here, we report the effect of repeated exposures to the same magnetically shielded environment...
- The pharmacogenetics of analgesia
Ulrike M Stamer
Rheinische Friedrich Wilhelms Universitat Bonn, Department of Anaesthesiology and Intensive Care Medicine, Sigmund Freud Str 25, 53105 Bonn, Germany
Expert Opin Pharmacother 8:2235-45. 2007
..on CYP2C9 activity, whereas opioid-receptor polymorphisms are discussed for differences in opioid mediated analgesia and side effects...
- Exploratory findings with virtual reality for phantom limb pain; from stump motion to agency and analgesia
Department of Clinical Neurophysiology, Poole Hospital, Poole, UK
Disabil Rehabil 31:846-54. 2009
- The efficacy of a novel approach to transversus abdominis plane block for postoperative analgesia after colorectal surgery
Department of Anesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Anesth Analg 112:1504-8. 2011
..We evaluated the efficacy of a novel approach to TAP block for postoperative analgesia after colorectal surgery.
- Placebo conditioning and placebo analgesia modulate a common brain network during pain anticipation and perception
Human Pain Research Group, University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford M6 8HD, UK
Pain 145:24-30. 2009
The neural mechanisms whereby placebo conditioning leads to placebo analgesia remain unclear. In this study we aimed to identify the brain structures activated during placebo conditioning and subsequent placebo analgesia...
- Neuraxial drug administration: a review of treatment options for anaesthesia and analgesia
Stephan A Schug
Pharmacology Unit, School of Medicine and Pharmacology, UWA Anaesthesia, University of Western Australia, Perth, WA, Australia
CNS Drugs 20:917-33. 2006
..a wide range of techniques to administer a large number of different drugs to provide anaesthesia, but also analgesia and treatment of spasticity in a variety of acute and chronic settings...
- Predicting individual differences in placebo analgesia: contributions of brain activity during anticipation and pain experience
Tor D Wager
Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
J Neurosci 31:439-52. 2011
Recent studies have identified brain correlates of placebo analgesia, but none have assessed how accurately patterns of brain activity can predict individual differences in placebo responses...
- A procedure-specific systematic review and consensus recommendations for analgesia after total hip replacement
H B J Fischer
Anaesthesia and Pain Management, Department of Anaesthesia, Alexandra Hospital, Redditch, Worcestershire, UK
Anaesthesia 60:1189-202. 2005
..The primary analgesic technique should be combined with a step-down approach using paracetamol plus conventional non-steroidal anti-inflammatory drugs, with strong or weak opioids as required...
- High-dose local infiltration analgesia after hip and knee replacement--what is it, why does it work, and what are the future challenges?
Acta Orthop 78:159-61. 2007
- Adjunctive non-pharmacological analgesia for invasive medical procedures: a randomised trial
E V Lang
Beth Israel Deaconess Medical Center Harvard Medical School, Department of Radiology, Boston, MA 02215, USA
Lancet 355:1486-90. 2000
..We tested this assumption for patients undergoing percutaneous vascular and renal procedures in a prospective, randomised, single-centre study...
- Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the activation of different descending pain inhibitory mechanisms
Josie R T Silva
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Avenida Bandeirantes 3900, Ribeirao Preto, SP, Brazil
J Pain 12:51-60. 2011
..GABA(A) (bicuculline) and GABA(B) (phaclofen) receptors in blocking 2- or 100-Hz electroacupuncture (EA)-induced analgesia (EAIA) in the rat tail-flick test...
- A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Proc Natl Acad Sci U S A 101:5135-9. 2004
..Furthermore, delta receptor antagonists enhance morphine-mediated intrathecal analgesia. Thus, heterodimeric associations between mu-delta opioid receptors can be used as a model for the development ..
- Trafficking of delta-opioid receptors and other G-protein-coupled receptors: implications for pain and analgesia
Catherine M Cahill
Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario K7L 3N6, Canada
Trends Pharmacol Sci 28:23-31. 2007
..Here, we highlight recent advances in this field, and provide examples of the importance of such trafficking events in pain...
- A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia
Darin D Dougherty
Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, MA 02129, USA
Behav Brain Res 193:63-8. 2008
..There is significant evidence that endogenous opioids are central to the experience of pain and analgesia. We applied an integrative multimodal imaging approach during acupuncture...
- Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
Mark R Hutchinson
Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Brain Behav Immun 22:1178-89. 2008
..Recently, one proinflammatory cytokine, interleukin-1, was also implicated in the loss of analgesia upon repeated morphine exposure (tolerance)...
- Risk assessment for and strategies to reduce perioperative pulmonary complications for patients undergoing noncardiothoracic surgery: a guideline from the American College of Physicians
American College of Physicians, Philadelphia, Pennsylvania 19106, USA
Ann Intern Med 144:575-80. 2006
..The target audience for this guideline is general internists or other clinicians involved in perioperative management of surgical patients. The target patient population is all adult persons undergoing noncardiothoracic surgery...
- Reproducibility of placebo analgesia: Effect of dispositional optimism
Debbie L Morton
Human Pain Research Group, University of Manchester Rheumatic Diseases Centre, Salford Royal Hospital, Salford, Manchester M6 8HD, UK
Pain 146:194-8. 2009
..We induced placebo analgesia by conditioning subjects to expect pain reduction following a sham-treatment in the guise of a local anaesthetic ..
- Gender differences in placebo analgesia: event-related potentials and emotional modulation
Per M Aslaksen
Department of Psychology, University of Tromsø, 9037 Tromsø, Norway
Psychosom Med 73:193-9. 2011
..Several experimental and clinical studies have shown that males report lower pain compared with females. There are, however, few reports of gender differences in placebo analgesia.
- Rapid development of tolerance to analgesia during remifentanil infusion in humans
H R Vinik
Department of Anesthesiology, University of Alabama at Birmingham, USA
Anesth Analg 86:1307-11. 1998
..We conclude that the development of tolerance should be included in the calculations for target-controlled infusions...
- Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients
Karen V Andersen
Department of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark
Acta Orthop 78:180-6. 2007
Epidural analgesia gives excellent pain relief but is associated with substantial side effects...
- Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration
Lasse Juel Andersen
Department of Orthopaedic Surgery, Odense University Hospital, Middelfart, Denmark
Acta Orthop 78:187-92. 2007
..Comfort and lack of pain are important for optimal mobilization after hip replacement. We investigated the efficacy of double wound infiltration...
- The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans
Jeffrey S Mogil
Department of Psychology, McGill University, Montreal, QC, Canada H3A 1B1
Proc Natl Acad Sci U S A 100:4867-72. 2003
..information has been demonstrated in rodents, and these qualitative sex differences appear to be relevant to analgesia from kappa-opioid receptor agonists, a drug class reported to be clinically effective only in women...
- A systematic review of randomized trials evaluating regional techniques for postthoracotomy analgesia
Girish P Joshi
Department of Anesthesiology and Pain Management, University of TX Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9068, USA
Anesth Analg 107:1026-40. 2008
Thoracotomy induces severe postoperative pain and impairment of pulmonary function, and therefore regional analgesia has been intensively studied in this procedure...
- Infant pain management: a developmental neurobiological approach
Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
Nat Clin Pract Neurol 5:35-50. 2009
..The evidence that untreated pain in infancy results in long-term adverse consequences is presented, thereby emphasizing the need for a longer term view of infant pain management...
- Descending analgesia--when the spine echoes what the brain expects
Universite de Sherbrooke, Faculte de Medecine, Sherbrooke, Que, Canada J1H 5N4
Pain 130:137-43. 2007
Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions...
- Effect of the blockade of mu1-opioid and 5HT2A-serotonergic/alpha1-noradrenergic receptors on sweet-substance-induced analgesia
E C C Rebouças
Laboratório de Neuroanatomia e Neuropsicobiologia, Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto USP, Avenida dos Bandeirantes, 3900, Ribeirao Preto SP, 14049 900, Brasil
Psychopharmacology (Berl) 179:349-55. 2005
Sweet-substance-induced analgesia has been widely studied, and the investigation of the neurotransmitters involved in this antinociceptive process is an important way for understanding the involvement of the neural system controlling ..
- Sucrose analgesia: identifying potentially better practices
Children s Hospital and Research Center, 747 52nd St, Neonatology, Oakland, CA 94609, USA
Pediatrics 118:S197-202. 2006
- Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla
Richard L Suplita
Department of Psychology, Neuroscience and Behavior Program, University of Georgia, Athens, GA 30602 3013, USA
Neuropharmacology 49:1201-9. 2005
..In this work, CB(1) antagonists administered systemically blocked stress-induced analgesia induced by brief, continuous foot-shock...
- Prolonged sedation and/or analgesia and 5-year neurodevelopment outcome in very preterm infants: results from the EPIPAGE cohort
Jean Christophe Roze
Department of Neonatal Medicine and Centre d Investigation Clinique INSERM CIC004, Hôpital de Mère et l Enfant, Boulevard Jean Monet, 44000 Nantes, France
Arch Pediatr Adolesc Med 162:728-33. 2008
To describe the long-term outcome of very preterm infants receiving prolonged sedation and/or analgesia and examine the relationship between prolonged sedation and/or analgesia and this long-term outcome.
- Pain and analgesia: The dual effect of nitric oxide in the nociceptive system
Special Laboratory of Pain and Signaling, Butantan Institute, Vital Brazil Avenida, 1500, 05503 900 Sao Paulo, SP, Brazil
Nitric Oxide 25:243-54. 2011
- [Case with difficulty in differentiating between transient neuroleptic malignant syndrome and catatonia after neuroleptic analgesia]
Department of Traumatology and Critical Care Medicine, National Defense Medical College, Tokorozawa 359 8513
Masui 59:235-7. 2010
An 18-year-old woman was treated with neuroleptic analgesia using fentanyl, morphine, droperidol and haloperidol for general anesthesia and pain control for her knee operation...
- Intraoperative local infiltration analgesia for early analgesia after total hip arthroplasty: a randomized, double-blind, placebo-controlled trial
Troels H Lunn
Department of Anesthesiology, Hvidovre University Hospital, Copenhagen, Denmark
Reg Anesth Pain Med 36:424-9. 2011
High-volume local infiltration analgesia (LIA) is widely applied as part of a multimodal pain management strategy in total hip arthroplasty (THA)...
- Direct evidence for spinal cord involvement in placebo analgesia
Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
Science 326:404. 2009
Placebo analgesia is a prime example of the impact that psychological factors have on pain perception...
- Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia
Mark R Hutchinson
Discipline of Pharmacology, School of Medical Science, University of Adelaide, South Australia, Australia, 5005
Pharmacol Rev 63:772-810. 2011
..Novel pharmacological targets for future drug development are discussed in the hope that disease-modifying chronic pain treatments arising from the appreciation of opioid-induced central immune signaling may become practical...
- Analgesia before a spinal block for femoral neck fracture: fascia iliaca compartment block
M J Yun
Department of Anaesthesiology and Pain Medicine, College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi Do, Korea
Acta Anaesthesiol Scand 53:1282-7. 2009
..v.) alfentanil when administered to facilitate positioning for spinal anaesthesia in elderly patients undergoing surgery for a femoral neck fracture...
- Effects of lidocaine constant rate infusion on sevoflurane requirement, autonomic responses, and postoperative analgesia in dogs undergoing ovariectomy under opioid-based balanced anesthesia
Dipartimento di Patologia e Clinica Veterinaria, Sezione di Clinica Chirurgica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Sassari, I 07100 Sassari, Italy
Vet J 193:448-55. 2012
..opioid-based balanced anesthesia with lidocaine (50 μg/kg/min) may not have any or only a minor impact on anesthetic outcome in terms of total anesthetic dose, autonomic responses to visceral nociception, and postoperative analgesia.
- Dispositional optimism predicts placebo analgesia
Andrew L Geers
Department of Psychology, University of Toledo, Toledo, Ohio 43606 3390, USA
J Pain 11:1165-71. 2010
- TRP channels and analgesia
Louis S Premkumar
Department of Pharmacology, Southern Illinois University School of Medicine Springfield, IL 62702, USA
Life Sci 92:415-24. 2013
- White matter integrity of the descending pain modulatory system is associated with interindividual differences in placebo analgesia
Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Germany
Pain 153:2210-7. 2012
..The mechanisms underlying this interindividual difference are incompletely understood. We used placebo analgesia as a classic model of endogenous pain modulation in combination with diffusion tensor magnetic resonance imaging ..
- Emergency department analgesia for fracture pain
Julie C Brown
Department of Pediatrics, University of Washington, School of Medicine and the Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
Ann Emerg Med 42:197-205. 2003
..all emergency department (ED) patients with extremity or clavicular fractures to describe analgesic use, compare analgesia between adults and children, and compare analgesia between the subset of these adults and children with ..
- Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia
Biosciences Division, SRI International, Menlo Park, California 94025, USA
J Clin Invest 118:2471-81. 2008
Stress-induced analgesia (SIA) is a key component of the defensive behavioral "fight-or-flight" response...
- Enhancement of offset analgesia during sequential testing
S W G Derbyshire
University of Birmingham, School of Psychology, Edgbaston, B15 2TT, UK
Eur J Pain 12:980-9. 2008
..This disproportionate reduction in pain experience, known as offset analgesia, is presumably mediated by a mechanism different to adaptation or habituation...
- An individual variation study of electroacupuncture analgesia in rats using microarray
Yu Zhen Gao
Department of Neurobiology, School of Medicine, Soochow University, Suzhou 215123, China
Am J Chin Med 35:767-78. 2007
The aim of the present study is to probe candidate genes which were involved in the electroacupuncture (EA) analgesia and to understand the molecular basis of the individual difference of EA analgesia in rats...
- Procedural sedation and analgesia in the emergency department
Alan J Smally
Division of Emergency Medicine, Department of Traumatology and Emergency Medicine, Hartford Hospital, Hartford, Connecticut 06102, USA
Curr Opin Crit Care 17:317-22. 2011
Procedural sedation and analgesia is frequently administered outside of the operating room in emergency departments (EDs) and ICUs. Evidence was sought concerning patients' safety in the ED.
- Persistent pain and stress activate pain-inhibitory orexin pathways
Department of Autonomic Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba 260 8670, Japan
Neuroreport 16:5-8. 2005
..mice presented greater degree of hyperalgesia induced by peripheral inflammation and less stress-induced analgesia than wild type mice...
- Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP
Department of Entomology and University of California Davis Cancer Center, School of Medicine, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 108:5093-7. 2011
..The cross-talk between the two major pathways-one mediated by cAMP and the other by EFAs-paves the way to new approaches to understand and control pain...
- Efficacy of ultrasound-guided transversus abdominis plane (TAP) block for postcesarean section delivery analgesia--a double-blind, placebo-controlled, randomized study
Jumana M Baaj
Department of Anaesthesia, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Middle East J Anaesthesiol 20:821-6. 2010
Ultrasound-guided transversus abdominis plane (TAP) block has been used for intra-operative and postoperative analgesia. Here we evaluate the efficacy of TAP block for postoperative cesarean delivery analgesia.
- An analysis of renal dysfunction in 1511 patients with fractured neck of femur: the implications for peri-operative analgesia
S M White
Royal Sussex County Hospital, Brighton, East Sussex, UK
Anaesthesia 64:1061-5. 2009
..06). Renal impairment is common in patients admitted for fixation of fractured neck of femur, who are consequently at risk of opioid toxicity...
- Analgesia delivery in the ED
Paul S Grant
Department of Medicine, Royal Sussex County Hospital, Brighton, BN2 5BE, UK
Am J Emerg Med 24:806-9. 2006
The aim of this study was to evaluate the effectiveness of analgesia delivery, in the emergency department setting, to patients presenting with acute pain, with regard to guidelines from the British Association of Accident and Emergency ..
- NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain
Kristin E Smith
Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Behav Brain Res 232:93-7. 2012
..two major neurotensin receptors, NTS1 and NTS2, to elicit effects similar to those of endogenous NT, including analgesia. Previous data strongly suggest NTS2 as the main receptor involved in NT- and NT analog-mediated visceral ..
- Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
Pain 115:50-9. 2005
..We report that administration of a neutral dose of IL-1beta abolished morphine analgesia in mice, whereas acute or chronic blockade of IL-1 signaling by various IL-1 blockers (IL-1 receptor antagonist (..
- Dexamethasone added to mepivacaine prolongs the duration of analgesia after supraclavicular brachial plexus blockade
Simon J Parrington
Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Reg Anesth Pain Med 35:422-6. 2010
..We hypothesized that the addition of dexamethasone to mepivacaine would prolong the duration of analgesia after ultrasound-guided supraclavicular brachial plexus block for patients undergoing upper-limb surgery.
- Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer
Department of Anesthesiology, Aretaieion Hospital, Medical School, University of Athens, Athens, Greece
Anesth Analg 101:1427-32. 2005
We evaluated the effect of multimodal analgesia on acute and chronic pain after breast surgery for cancer...
- Sex and gender differences in pain and analgesia
Jeffrey S Mogil
Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada
Prog Brain Res 186:141-57. 2010
..Although not yet able to affect clinical practice, the continued study of sex differences in pain may have important implications for the development of new analgesic strategies...
- Changes in morphine analgesia and side effects during daily subcutaneous administration in healthy volunteers
Karin Lottrup Petersen
Department of Neurology, UCSF Pain Clinical Research Center, University of San Francisco, CA, USA
Pain 137:395-404. 2008
..As 4 days is the threshold for demonstrating analgesic tolerance to twice-daily morphine in animal models, a longer period of opioid exposure in healthy volunteers might be needed to detect analgesic tolerance...
- Randomized prospective study comparing preoperative epidural and intraoperative perineural analgesia for the prevention of postoperative stump and phantom limb pain following major amputation
Vascular Surgery Unit and Department of Anaesthesia, Derriford Hospital, Plymouth, United Kingdom
Reg Anesth Pain Med 26:316-21. 2001
..Epidural analgesia before limb amputation is commonly used to reduce postamputation acute stump pain in the immediate postoperative ..
- Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol)
Garry G Graham
Department of Physiology and Pharmacology, School of Medical Sciences, Faculty of Medicine, Sydney, 2052, Australia
Curr Pharm Des 8:1063-75. 2002
..No such associations have been made with acetaminophen, possibly because it is a weak inhibitor of COX-1 in platelets...
- Extrasegmental analgesia of heterotopic electroacupuncture stimulation on visceral pain rats
Guangzhou University of Traditional Chinese Medicine, 12 Jichang Road, Guangzhou 510006, PR China
Brain Res 1373:160-71. 2011
..However, the underlying mechanism still remains unknown. In the present study, extrasegmental analgesia of electroacupuncture (EA) at orofacial acupoints on visceral pain rats was investigated...