analgesia

Summary

Top Publications

  1. ncbi Placebo and opioid analgesia-- imaging a shared neuronal network
    Predrag Petrovic
    Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
    Science 295:1737-40. 2002
  2. pmc Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
    Gregory Scherrer
    Department of Anatomy and Physiology and WM Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, USA
    Cell 137:1148-59. 2009
  3. ncbi Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions
    David Borsook
    P A I N Group, Massachusetts General Hospital, McLean Hospital, and Children s Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Discov Med 11:197-207. 2011
  4. ncbi Linking pain and the body: neural correlates of visually induced analgesia
    Matthew R Longo
    Department of Psychological Sciences, Birkbeck, University of London, London, UK
    J Neurosci 32:2601-7. 2012
  5. pmc tDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine
    Alexandre F DaSilva
    Headache and Orofacial Pain Effort, Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    Headache 52:1283-95. 2012
  6. ncbi Visually induced analgesia: seeing the body reduces pain
    Matthew R Longo
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
    J Neurosci 29:12125-30. 2009
  7. ncbi Loss of peripheral morphine analgesia contributes to the reduced effectiveness of systemic morphine in neuropathic pain
    Md Harunor Rashid
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 309:380-7. 2004
  8. ncbi Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: do conditioning stimulus painfulness, gender and personality variables matter?
    Michal Granot
    Faculty of Social Welfare and Health Studies, University of Haifa, Israel
    Pain 136:142-9. 2008
  9. ncbi Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging
    David Borsook
    P A I N Group, Massachusetts General Hospital, McLean Hospital, and Children s Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Discov Med 11:209-19. 2011
  10. ncbi Central mechanisms of menthol-induced analgesia
    Rong Pan
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Pharmacol Exp Ther 343:661-72. 2012

Detail Information

Publications343 found, 100 shown here

  1. ncbi Placebo and opioid analgesia-- imaging a shared neuronal network
    Predrag Petrovic
    Cognitive Neurophysiology Research Group, Department of Clinical Neuroscience, Karolinska Institute, Stockholm 171 76, Sweden, Pain Clinic, Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Finland
    Science 295:1737-40. 2002
    It has been suggested that placebo analgesia involves both higher order cognitive networks and endogenous opioid systems...
  2. pmc Dissociation of the opioid receptor mechanisms that control mechanical and heat pain
    Gregory Scherrer
    Department of Anatomy and Physiology and WM Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94158, USA
    Cell 137:1148-59. 2009
    ..These results demonstrate that behaviorally relevant pain modalities can be selectively regulated through the targeting of distinct subsets of primary afferent pain fibers...
  3. ncbi Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions
    David Borsook
    P A I N Group, Massachusetts General Hospital, McLean Hospital, and Children s Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Discov Med 11:197-207. 2011
    ..Chronic pain is now considered to be a disease of the central nervous system. Since behavior (including pain or analgesia) results from activity in brain circuits through the participation of many brain regions, we suggest that ..
  4. ncbi Linking pain and the body: neural correlates of visually induced analgesia
    Matthew R Longo
    Department of Psychological Sciences, Birkbeck, University of London, London, UK
    J Neurosci 32:2601-7. 2012
    The visual context of seeing the body can reduce the experience of acute pain, producing a multisensory analgesia. Here we investigated the neural correlates of this "visually induced analgesia" using fMRI...
  5. pmc tDCS-induced analgesia and electrical fields in pain-related neural networks in chronic migraine
    Alexandre F DaSilva
    Headache and Orofacial Pain Effort, Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    Headache 52:1283-95. 2012
    ..In addition, using a high-resolution tDCS computational model, we analyzed the current flow (electric field) through brain regions associated with pain perception and modulation...
  6. ncbi Visually induced analgesia: seeing the body reduces pain
    Matthew R Longo
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
    J Neurosci 29:12125-30. 2009
    ..Furthermore, these effects were specific to vision of one's own hand and were absent when viewing another person's hand. These results demonstrate a novel analgesic effect of non-informative vision of the body...
  7. ncbi Loss of peripheral morphine analgesia contributes to the reduced effectiveness of systemic morphine in neuropathic pain
    Md Harunor Rashid
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 309:380-7. 2004
    ..the decreased effectiveness of systemic morphine in neuropathic pain might be caused by the loss of morphine analgesia at the periphery. When given s.c. or i.t...
  8. ncbi Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: do conditioning stimulus painfulness, gender and personality variables matter?
    Michal Granot
    Faculty of Social Welfare and Health Studies, University of Haifa, Israel
    Pain 136:142-9. 2008
    ..the association between parameters of the conditioning stimulus, gender and personality, and the endogenous analgesia (EA) extent assessed by diffuse noxious inhibitory control (DNIC) paradigm...
  9. ncbi Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging
    David Borsook
    P A I N Group, Massachusetts General Hospital, McLean Hospital, and Children s Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Discov Med 11:209-19. 2011
    ..An important area for future research is to image clinical ongoing pain to further our knowledge of brain function in different pain states and the effects of treatment...
  10. ncbi Central mechanisms of menthol-induced analgesia
    Rong Pan
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
    J Pharmacol Exp Ther 343:661-72. 2012
    ..These data provide molecular and cellular mechanisms by which menthol decreases neuronal excitability, therefore contributing to menthol-induced central analgesia.
  11. ncbi Enhanced morphine analgesia in mice lacking beta-arrestin 2
    L M Bohn
    Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 286:2495-8. 1999
    ..Moreover, they suggest that inhibition of beta-arrestin 2 function might lead to enhanced analgesic effectiveness of morphine and provide potential new avenues for the study and treatment of pain, narcotic tolerance, and dependence...
  12. ncbi Femoral nerve block improves analgesia outcomes after total knee arthroplasty: a meta-analysis of randomized controlled trials
    James E Paul
    Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada
    Anesthesiology 113:1144-62. 2010
    Femoral nerve blockade (FNB) is a common method of analgesia for postoperative pain control after total knee arthroplasty...
  13. ncbi High-volume infiltration analgesia in total knee arthroplasty: a randomized, double-blind, placebo-controlled trial
    L Ø Andersen
    Department of Anesthesiology, Hvidovre University Hospital, Copenhagen, Denmark
    Acta Anaesthesiol Scand 52:1331-5. 2008
    High-volume infiltration analgesia may be effective with a low risk of side effects in hip and knee arthroplasty...
  14. ncbi Stress-induced analgesia
    Ryan K Butler
    Department of Pharmacology and Therapeutics, NCBES Neuroscience Cluster and Centre for Pain Research, National University of Ireland, Galway, University Road, Galway, Ireland
    Prog Neurobiol 88:184-202. 2009
    ..suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that ..
  15. ncbi An endocannabinoid mechanism for stress-induced analgesia
    Andrea G Hohmann
    Neuroscience and Behavior Program, Department of Psychology, The University of Georgia, Athens, Georgia 30602 3013, USA
    Nature 435:1108-12. 2005
    ..Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain...
  16. ncbi Activation of the opioidergic descending pain control system underlies placebo analgesia
    Falk Eippert
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Neuron 63:533-43. 2009
    Placebo analgesia involves the endogenous opioid system, as administration of the opioid antagonist naloxone decreases placebo analgesia...
  17. ncbi Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients
    Dennis R Kerr
    Joint Orthopaedic Centre, New South Wales, Australia
    Acta Orthop 79:174-83. 2008
    ..a multimodal technique for the control of pain following knee and hip surgery, called "local infiltration analgesia" (LIA)...
  18. ncbi Leukocytes in the regulation of pain and analgesia
    H L Rittner
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Hindenburgdamm 30, D 12200 Berlin, Germany
    J Leukoc Biol 78:1215-22. 2005
    ..opioid peptides and opioid receptors can lead to potent, clinically relevant inhibition of pain (analgesia). Opioid receptors are present on peripheral endings of sensory neurons...
  19. ncbi How prior experience shapes placebo analgesia
    Luana Colloca
    Department of Neuroscience, Clinical and Applied Physiology Program, University of Turin Medical School, Turin, Italy
    Pain 124:126-33. 2006
    Some studies indicate that placebo analgesia is stronger when pre-conditioning with effective analgesic treatments is performed, thereby suggesting that the placebo response is a learning phenomenon...
  20. pmc Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain
    Marwan N Baliki
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 66:149-60. 2010
    ..Therefore, in contrast to somatosensory pathways, which reflect sensory properties of acute noxious stimuli, NAc activity in humans encodes its predicted value and anticipates its analgesic potential on chronic pain...
  21. pmc Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version
    JORG MARTIN
    Department of Anesthesiology and Operative Intensive Care, Klinik am Eichert, Goppingen, Germany
    Ger Med Sci 8:Doc02. 2010
    Targeted monitoring of analgesia, sedation and delirium, as well as their appropriate management in critically ill patients is a standard of care in intensive care medicine...
  22. pmc COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia
    M Farooqui
    1Division of Hematology, Oncology and Transplantation, the Vascular Biology Center, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Br J Cancer 97:1523-31. 2007
    ..if celecoxib (a cyclooxygenase-2 (COX-2) inhibitor) prevents morphine-induced tumour growth without compromising analgesia. The effect of chronic treatment with celecoxib (by gavage) and/or morphine (subcutaneously), or PBS on tumour ..
  23. ncbi Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin
    L Vyklicky
    Department of Cellular Neurophysiology, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 57:S59-68. 2008
    ..desensitization of TRPV1 channels and explores to what extent they may contribute to capsaicin-induced analgesia. In view of the polymodal nature of TRPV1, we illustrate how the channels behave in their desensitized state ..
  24. pmc A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia
    Wendy M Knowlton
    Neurobiology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 33:2837-48. 2013
    ..Moreover, cooling-induced analgesia after nerve injury was abolished in both genotypes...
  25. pmc A key role of the basal ganglia in pain and analgesia--insights gained through human functional imaging
    David Borsook
    PAIN Group, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Mol Pain 6:27. 2010
    ..These include the integration of motor, emotional, autonomic and cognitive responses to pain...
  26. ncbi Comparison of neosaxitoxin versus bupivacaine via port infiltration for postoperative analgesia following laparoscopic cholecystectomy: a randomized, double-blind trial
    Alberto J Rodriguez-Navarro
    Department of Surgery, Hospital Padre Hurtado, Santiago, Chile
    Reg Anesth Pain Med 36:103-9. 2011
    Wound infiltration with available local anesthetics generally provides analgesia for less than 8 hrs. The site 1 sodium-channel toxin neosaxitoxin (neoSTX) produced analgesia for over 24 hrs in animals and human volunteers...
  27. ncbi Epigenetics in pain and analgesia: an imminent research field
    Alexandra Doehring
    Pharmazentrum frankfurt ZAFES, Institute for Clinical Pharmacology, Goethe University, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Eur J Pain 15:11-6. 2011
    ..Thus, the new field of epigenetics becomes increasingly used in research and management of pain and will complement genetics. This article introduces epigenetics to pain and summarizes the current and future utility...
  28. ncbi Effectiveness of acute postoperative pain management: I. Evidence from published data
    S J Dolin
    Pain Clinic, St Richard s Hospital, Chichester PO19 4E, UK
    Br J Anaesth 89:409-23. 2002
    ..m.) analgesia, patient controlled analgesia (PCA), and epidural analgesia.
  29. ncbi Treating pain with pain: supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation
    Christian Sprenger
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Pain 152:428-39. 2011
    ..HNCS led to marked endogenous analgesia and this effect correlated positively with the perceived intensity of the tonic painful stimulus...
  30. ncbi Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Anesthesiology 113:1392-405. 2010
    ..The sites of action and cellular mechanisms by which spinal cord stimulation reduces neuropathic pain remain unclear...
  31. ncbi Involvement of spinal neurotrophin-3 in electroacupuncture analgesia and inhibition of spinal glial activation in rat model of monoarthritis
    Wen Li Mi
    Department of Integrative Medicine and Neurobiology, Institute of Acupuncture Research, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, China
    J Pain 12:974-84. 2011
    ..EA) has been proven to effectively relieve pain associated with arthritis, the underlying mechanism of EA analgesia requires further investigation...
  32. pmc Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids
    Xian Yu Liu
    Center for the Study of Itch, Washington University School of Medicine Pain Center, St Louis, MO 63110, USA
    Cell 147:447-58. 2011
    ..essential for morphine-induced scratching (MIS), whereas the isoform MOR1 is required only for morphine-induced analgesia (MIA)...
  33. ncbi Immune conditions associated with CD4+ T effector-induced opioid release and analgesia
    Jérôme Boué
    INSERM, U1043, Toulouse, France
    Pain 153:485-93. 2012
    ..Accordingly, analgesia was inhibited by neutralizing cognate T cell receptor-mediated interaction between effector CD4(+) T lymphocytes ..
  34. ncbi Sedation and analgesia in German intensive care units: how is it done in reality? Results of a patient-based survey of analgesia and sedation
    JORG MARTIN
    Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Hospital am Eichert, Eichertstrasse 3, 73035 Göppingen, Germany
    Intensive Care Med 32:1137-42. 2006
    This study carried out the first patient-oriented survey on the practice of analgesia and sedation in German intensive care units, examining whether the goals of early spontaneous breathing and awake, cooperative patients are achieved.
  35. ncbi Alarm pheromone induces stress analgesia via an opioid system in the honeybee
    J Nunez
    Department of Biological Sciences, FCEyN, Universidad de Buenos Aires, Argentina
    Physiol Behav 63:75-80. 1997
    ..The resulting stress-induced analgesia in the defender bee would reduce its probability of withdrawal thus increasing its efficiency against enemies.
  36. ncbi Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia
    Christophe Mallet
    INSERM E9904, U766, Facultes de Medecine et de Pharmacie, 28, Place Henri Dunant, B P 38, F 63001 Clermont Ferrand Cedex 01, France
    Pain 139:190-200. 2008
    ..We therefore propose that acetaminophen-induced analgesia could involve the following sequence: (1) FAAH-dependent metabolism of acetaminophen into AM404; (2) indirect ..
  37. pmc Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors
    Michelle Vincler
    Department of Anesthesiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 103:17880-4. 2006
    ..Our findings not only suggest a molecular mechanism for the treatment of neuropathic pain but also demonstrate the involvement of alpha9alpha10 nAChRs in the pathophysiology of peripheral nerve injury...
  38. ncbi Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data
    Suellen M Walker
    Portex Unit Pain Research, UCL Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, UK
    Anesth Analg 115:638-62. 2012
    ..Opioids or clonidine improves analgesia when added to perioperative epidural infusions; analgesia is significantly prolonged by the addition of ..
  39. ncbi Role of delivery and trafficking of delta-opioid peptide receptors in opioid analgesia and tolerance
    Xu Zhang
    Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Trends Pharmacol Sci 27:324-9. 2006
    ..Experiments in animals show that MOP-receptor-mediated spinal analgesia is enhanced and morphine tolerance does not develop when DOP receptor functions are pharmacologically or ..
  40. ncbi Sedation and analgesia in the mechanically ventilated patient
    Shruti B Patel
    Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Illinois, USA
    Am J Respir Crit Care Med 185:486-97. 2012
    Sedation and analgesia are important components of care for the mechanically ventilated patient in the intensive care unit (ICU)...
  41. ncbi I-SAVE study: impact of sedation, analgesia, and delirium protocols evaluated in the intensive care unit: an economic evaluation
    Don Kelena Awissi
    Pharmacy Department, Maisonneuve Rosemont Hospital, Montreal, Quebec, Canada
    Ann Pharmacother 46:21-8. 2012
    ..Intensive care units (ICUs) account for considerable health care costs. Adequate pain and sedation management is important to clinical care...
  42. ncbi Use of intrathecal midazolam to improve perioperative analgesia: a meta-analysis
    K M Ho
    Intensive Care Unit, Royal Perth Hospital, Perth, Western Australia, Australia
    Anaesth Intensive Care 36:365-73. 2008
    ..50, 95% confidence interval [CI] 0.27 to 0.90, P=0.02; I2=4%) and delayed the time to request for rescue analgesia (weighted-mean-difference=98.7 min, 95% CI: 76.1 to 121.4, P<0.00001; I2=98.5%)...
  43. ncbi Placebo analgesia affects the behavioral despair tests and hormonal secretions in mice
    Jian You Guo
    Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 10A Datun Road, Chaoyang District, Beijing 100101, People s Republic of China
    Psychopharmacology (Berl) 217:83-90. 2011
    ..2011) showed that, in human subjects, the placebo effect can be transferred from one domain to the other, namely from pain to emotion...
  44. ncbi Daily repeated magnetic field shielding induces analgesia in CD-1 mice
    Frank S Prato
    Department of Nuclear Medicine, Bioelectromagnetics, Lawson Health Research Institute, St Joseph s Health Care, London, Ontario N6A 4V2, Canada
    Bioelectromagnetics 26:109-17. 2005
    ..observed that a single exposure of mice to a magnetically shielded environment can attenuate opioid induced analgesia. Here, we report the effect of repeated exposures to the same magnetically shielded environment...
  45. ncbi The pharmacogenetics of analgesia
    Ulrike M Stamer
    Rheinische Friedrich Wilhelms Universitat Bonn, Department of Anaesthesiology and Intensive Care Medicine, Sigmund Freud Str 25, 53105 Bonn, Germany
    Expert Opin Pharmacother 8:2235-45. 2007
    ..on CYP2C9 activity, whereas opioid-receptor polymorphisms are discussed for differences in opioid mediated analgesia and side effects...
  46. ncbi Exploratory findings with virtual reality for phantom limb pain; from stump motion to agency and analgesia
    Jonathan Cole
    Department of Clinical Neurophysiology, Poole Hospital, Poole, UK
    Disabil Rehabil 31:846-54. 2009
    ....
  47. ncbi The efficacy of a novel approach to transversus abdominis plane block for postoperative analgesia after colorectal surgery
    Neerja Bharti
    Department of Anesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Anesth Analg 112:1504-8. 2011
    ..We evaluated the efficacy of a novel approach to TAP block for postoperative analgesia after colorectal surgery.
  48. pmc Placebo conditioning and placebo analgesia modulate a common brain network during pain anticipation and perception
    Alison Watson
    Human Pain Research Group, University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford M6 8HD, UK
    Pain 145:24-30. 2009
    The neural mechanisms whereby placebo conditioning leads to placebo analgesia remain unclear. In this study we aimed to identify the brain structures activated during placebo conditioning and subsequent placebo analgesia...
  49. ncbi Neuraxial drug administration: a review of treatment options for anaesthesia and analgesia
    Stephan A Schug
    Pharmacology Unit, School of Medicine and Pharmacology, UWA Anaesthesia, University of Western Australia, Perth, WA, Australia
    CNS Drugs 20:917-33. 2006
    ..a wide range of techniques to administer a large number of different drugs to provide anaesthesia, but also analgesia and treatment of spasticity in a variety of acute and chronic settings...
  50. pmc Predicting individual differences in placebo analgesia: contributions of brain activity during anticipation and pain experience
    Tor D Wager
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 31:439-52. 2011
    Recent studies have identified brain correlates of placebo analgesia, but none have assessed how accurately patterns of brain activity can predict individual differences in placebo responses...
  51. ncbi A procedure-specific systematic review and consensus recommendations for analgesia after total hip replacement
    H B J Fischer
    Anaesthesia and Pain Management, Department of Anaesthesia, Alexandra Hospital, Redditch, Worcestershire, UK
    Anaesthesia 60:1189-202. 2005
    ..The primary analgesic technique should be combined with a step-down approach using paracetamol plus conventional non-steroidal anti-inflammatory drugs, with strong or weak opioids as required...
  52. ncbi High-dose local infiltration analgesia after hip and knee replacement--what is it, why does it work, and what are the future challenges?
    Tord Röstlund
    Acta Orthop 78:159-61. 2007
  53. ncbi Adjunctive non-pharmacological analgesia for invasive medical procedures: a randomised trial
    E V Lang
    Beth Israel Deaconess Medical Center Harvard Medical School, Department of Radiology, Boston, MA 02215, USA
    Lancet 355:1486-90. 2000
    ..We tested this assumption for patients undergoing percutaneous vascular and renal procedures in a prospective, randomised, single-centre study...
  54. ncbi Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the activation of different descending pain inhibitory mechanisms
    Josie R T Silva
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto USP, Avenida Bandeirantes 3900, Ribeirao Preto, SP, Brazil
    J Pain 12:51-60. 2011
    ..GABA(A) (bicuculline) and GABA(B) (phaclofen) receptors in blocking 2- or 100-Hz electroacupuncture (EA)-induced analgesia (EAIA) in the rat tail-flick test...
  55. pmc A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia
    Ivone Gomes
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 101:5135-9. 2004
    ..Furthermore, delta receptor antagonists enhance morphine-mediated intrathecal analgesia. Thus, heterodimeric associations between mu-delta opioid receptors can be used as a model for the development ..
  56. ncbi Trafficking of delta-opioid receptors and other G-protein-coupled receptors: implications for pain and analgesia
    Catherine M Cahill
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Trends Pharmacol Sci 28:23-31. 2007
    ..Here, we highlight recent advances in this field, and provide examples of the importance of such trafficking events in pain...
  57. pmc A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia
    Darin D Dougherty
    Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, MA 02129, USA
    Behav Brain Res 193:63-8. 2008
    ..There is significant evidence that endogenous opioids are central to the experience of pain and analgesia. We applied an integrative multimodal imaging approach during acupuncture...
  58. pmc Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1178-89. 2008
    ..Recently, one proinflammatory cytokine, interleukin-1, was also implicated in the loss of analgesia upon repeated morphine exposure (tolerance)...
  59. ncbi Risk assessment for and strategies to reduce perioperative pulmonary complications for patients undergoing noncardiothoracic surgery: a guideline from the American College of Physicians
    Amir Qaseem
    American College of Physicians, Philadelphia, Pennsylvania 19106, USA
    Ann Intern Med 144:575-80. 2006
    ..The target audience for this guideline is general internists or other clinicians involved in perioperative management of surgical patients. The target patient population is all adult persons undergoing noncardiothoracic surgery...
  60. ncbi Reproducibility of placebo analgesia: Effect of dispositional optimism
    Debbie L Morton
    Human Pain Research Group, University of Manchester Rheumatic Diseases Centre, Salford Royal Hospital, Salford, Manchester M6 8HD, UK
    Pain 146:194-8. 2009
    ..We induced placebo analgesia by conditioning subjects to expect pain reduction following a sham-treatment in the guise of a local anaesthetic ..
  61. ncbi Gender differences in placebo analgesia: event-related potentials and emotional modulation
    Per M Aslaksen
    Department of Psychology, University of Tromsø, 9037 Tromsø, Norway
    Psychosom Med 73:193-9. 2011
    ..Several experimental and clinical studies have shown that males report lower pain compared with females. There are, however, few reports of gender differences in placebo analgesia.
  62. ncbi Rapid development of tolerance to analgesia during remifentanil infusion in humans
    H R Vinik
    Department of Anesthesiology, University of Alabama at Birmingham, USA
    Anesth Analg 86:1307-11. 1998
    ..We conclude that the development of tolerance should be included in the calculations for target-controlled infusions...
  63. ncbi Reduced hospital stay and narcotic consumption, and improved mobilization with local and intraarticular infiltration after hip arthroplasty: a randomized clinical trial of an intraarticular technique versus epidural infusion in 80 patients
    Karen V Andersen
    Department of Orthopedic Surgery, Aarhus University Hospital, Aarhus, Denmark
    Acta Orthop 78:180-6. 2007
    Epidural analgesia gives excellent pain relief but is associated with substantial side effects...
  64. ncbi Postoperative analgesia in total hip arthroplasty: a randomized double-blinded, placebo-controlled study on peroperative and postoperative ropivacaine, ketorolac, and adrenaline wound infiltration
    Lasse Juel Andersen
    Department of Orthopaedic Surgery, Odense University Hospital, Middelfart, Denmark
    Acta Orthop 78:187-92. 2007
    ..Comfort and lack of pain are important for optimal mobilization after hip replacement. We investigated the efficacy of double wound infiltration...
  65. pmc The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans
    Jeffrey S Mogil
    Department of Psychology, McGill University, Montreal, QC, Canada H3A 1B1
    Proc Natl Acad Sci U S A 100:4867-72. 2003
    ..information has been demonstrated in rodents, and these qualitative sex differences appear to be relevant to analgesia from kappa-opioid receptor agonists, a drug class reported to be clinically effective only in women...
  66. ncbi A systematic review of randomized trials evaluating regional techniques for postthoracotomy analgesia
    Girish P Joshi
    Department of Anesthesiology and Pain Management, University of TX Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9068, USA
    Anesth Analg 107:1026-40. 2008
    Thoracotomy induces severe postoperative pain and impairment of pulmonary function, and therefore regional analgesia has been intensively studied in this procedure...
  67. ncbi Infant pain management: a developmental neurobiological approach
    Maria Fitzgerald
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Clin Pract Neurol 5:35-50. 2009
    ..The evidence that untreated pain in infancy results in long-term adverse consequences is presented, thereby emphasizing the need for a longer term view of infant pain management...
  68. ncbi Descending analgesia--when the spine echoes what the brain expects
    Philippe Goffaux
    Universite de Sherbrooke, Faculte de Medecine, Sherbrooke, Que, Canada J1H 5N4
    Pain 130:137-43. 2007
    Changes in pain produced by psychological factors (e.g., placebo analgesia) are thought to result from the activity of specific cortical regions...
  69. ncbi Effect of the blockade of mu1-opioid and 5HT2A-serotonergic/alpha1-noradrenergic receptors on sweet-substance-induced analgesia
    E C C Rebouças
    Laboratório de Neuroanatomia e Neuropsicobiologia, Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto USP, Avenida dos Bandeirantes, 3900, Ribeirao Preto SP, 14049 900, Brasil
    Psychopharmacology (Berl) 179:349-55. 2005
    Sweet-substance-induced analgesia has been widely studied, and the investigation of the neurotransmitters involved in this antinociceptive process is an important way for understanding the involvement of the neural system controlling ..
  70. ncbi Sucrose analgesia: identifying potentially better practices
    Linda Lefrak
    Children s Hospital and Research Center, 747 52nd St, Neonatology, Oakland, CA 94609, USA
    Pediatrics 118:S197-202. 2006
    ....
  71. ncbi Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla
    Richard L Suplita
    Department of Psychology, Neuroscience and Behavior Program, University of Georgia, Athens, GA 30602 3013, USA
    Neuropharmacology 49:1201-9. 2005
    ..In this work, CB(1) antagonists administered systemically blocked stress-induced analgesia induced by brief, continuous foot-shock...
  72. ncbi Prolonged sedation and/or analgesia and 5-year neurodevelopment outcome in very preterm infants: results from the EPIPAGE cohort
    Jean Christophe Roze
    Department of Neonatal Medicine and Centre d Investigation Clinique INSERM CIC004, Hôpital de Mère et l Enfant, Boulevard Jean Monet, 44000 Nantes, France
    Arch Pediatr Adolesc Med 162:728-33. 2008
    To describe the long-term outcome of very preterm infants receiving prolonged sedation and/or analgesia and examine the relationship between prolonged sedation and/or analgesia and this long-term outcome.
  73. ncbi Pain and analgesia: The dual effect of nitric oxide in the nociceptive system
    Yara Cury
    Special Laboratory of Pain and Signaling, Butantan Institute, Vital Brazil Avenida, 1500, 05503 900 Sao Paulo, SP, Brazil
    Nitric Oxide 25:243-54. 2011
    ....
  74. ncbi [Case with difficulty in differentiating between transient neuroleptic malignant syndrome and catatonia after neuroleptic analgesia]
    Youichi Yanagawa
    Department of Traumatology and Critical Care Medicine, National Defense Medical College, Tokorozawa 359 8513
    Masui 59:235-7. 2010
    An 18-year-old woman was treated with neuroleptic analgesia using fentanyl, morphine, droperidol and haloperidol for general anesthesia and pain control for her knee operation...
  75. ncbi Intraoperative local infiltration analgesia for early analgesia after total hip arthroplasty: a randomized, double-blind, placebo-controlled trial
    Troels H Lunn
    Department of Anesthesiology, Hvidovre University Hospital, Copenhagen, Denmark
    Reg Anesth Pain Med 36:424-9. 2011
    High-volume local infiltration analgesia (LIA) is widely applied as part of a multimodal pain management strategy in total hip arthroplasty (THA)...
  76. ncbi Direct evidence for spinal cord involvement in placebo analgesia
    Falk Eippert
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Science 326:404. 2009
    Placebo analgesia is a prime example of the impact that psychological factors have on pain perception...
  77. pmc Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia
    Mark R Hutchinson
    Discipline of Pharmacology, School of Medical Science, University of Adelaide, South Australia, Australia, 5005
    Pharmacol Rev 63:772-810. 2011
    ..Novel pharmacological targets for future drug development are discussed in the hope that disease-modifying chronic pain treatments arising from the appreciation of opioid-induced central immune signaling may become practical...
  78. ncbi Analgesia before a spinal block for femoral neck fracture: fascia iliaca compartment block
    M J Yun
    Department of Anaesthesiology and Pain Medicine, College of Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi Do, Korea
    Acta Anaesthesiol Scand 53:1282-7. 2009
    ..v.) alfentanil when administered to facilitate positioning for spinal anaesthesia in elderly patients undergoing surgery for a femoral neck fracture...
  79. ncbi Effects of lidocaine constant rate infusion on sevoflurane requirement, autonomic responses, and postoperative analgesia in dogs undergoing ovariectomy under opioid-based balanced anesthesia
    Nicolò Columbano
    Dipartimento di Patologia e Clinica Veterinaria, Sezione di Clinica Chirurgica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Sassari, I 07100 Sassari, Italy
    Vet J 193:448-55. 2012
    ..opioid-based balanced anesthesia with lidocaine (50 μg/kg/min) may not have any or only a minor impact on anesthetic outcome in terms of total anesthetic dose, autonomic responses to visceral nociception, and postoperative analgesia.
  80. pmc Dispositional optimism predicts placebo analgesia
    Andrew L Geers
    Department of Psychology, University of Toledo, Toledo, Ohio 43606 3390, USA
    J Pain 11:1165-71. 2010
    ....
  81. ncbi TRP channels and analgesia
    Louis S Premkumar
    Department of Pharmacology, Southern Illinois University School of Medicine Springfield, IL 62702, USA
    Life Sci 92:415-24. 2013
    ....
  82. ncbi White matter integrity of the descending pain modulatory system is associated with interindividual differences in placebo analgesia
    Niklas Stein
    Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Germany
    Pain 153:2210-7. 2012
    ..The mechanisms underlying this interindividual difference are incompletely understood. We used placebo analgesia as a classic model of endogenous pain modulation in combination with diffusion tensor magnetic resonance imaging ..
  83. ncbi Emergency department analgesia for fracture pain
    Julie C Brown
    Department of Pediatrics, University of Washington, School of Medicine and the Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Ann Emerg Med 42:197-205. 2003
    ..all emergency department (ED) patients with extremity or clavicular fractures to describe analgesic use, compare analgesia between adults and children, and compare analgesia between the subset of these adults and children with ..
  84. pmc Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia
    Xinmin Xie
    Biosciences Division, SRI International, Menlo Park, California 94025, USA
    J Clin Invest 118:2471-81. 2008
    Stress-induced analgesia (SIA) is a key component of the defensive behavioral "fight-or-flight" response...
  85. ncbi Enhancement of offset analgesia during sequential testing
    S W G Derbyshire
    University of Birmingham, School of Psychology, Edgbaston, B15 2TT, UK
    Eur J Pain 12:980-9. 2008
    ..This disproportionate reduction in pain experience, known as offset analgesia, is presumably mediated by a mechanism different to adaptation or habituation...
  86. ncbi An individual variation study of electroacupuncture analgesia in rats using microarray
    Yu Zhen Gao
    Department of Neurobiology, School of Medicine, Soochow University, Suzhou 215123, China
    Am J Chin Med 35:767-78. 2007
    The aim of the present study is to probe candidate genes which were involved in the electroacupuncture (EA) analgesia and to understand the molecular basis of the individual difference of EA analgesia in rats...
  87. ncbi Procedural sedation and analgesia in the emergency department
    Alan J Smally
    Division of Emergency Medicine, Department of Traumatology and Emergency Medicine, Hartford Hospital, Hartford, Connecticut 06102, USA
    Curr Opin Crit Care 17:317-22. 2011
    Procedural sedation and analgesia is frequently administered outside of the operating room in emergency departments (EDs) and ICUs. Evidence was sought concerning patients' safety in the ED.
  88. ncbi Persistent pain and stress activate pain-inhibitory orexin pathways
    Shinji Watanabe
    Department of Autonomic Physiology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba 260 8670, Japan
    Neuroreport 16:5-8. 2005
    ..mice presented greater degree of hyperalgesia induced by peripheral inflammation and less stress-induced analgesia than wild type mice...
  89. pmc Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP
    Bora Inceoglu
    Department of Entomology and University of California Davis Cancer Center, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 108:5093-7. 2011
    ..The cross-talk between the two major pathways-one mediated by cAMP and the other by EFAs-paves the way to new approaches to understand and control pain...
  90. ncbi Efficacy of ultrasound-guided transversus abdominis plane (TAP) block for postcesarean section delivery analgesia--a double-blind, placebo-controlled, randomized study
    Jumana M Baaj
    Department of Anaesthesia, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
    Middle East J Anaesthesiol 20:821-6. 2010
    Ultrasound-guided transversus abdominis plane (TAP) block has been used for intra-operative and postoperative analgesia. Here we evaluate the efficacy of TAP block for postoperative cesarean delivery analgesia.
  91. ncbi An analysis of renal dysfunction in 1511 patients with fractured neck of femur: the implications for peri-operative analgesia
    S M White
    Royal Sussex County Hospital, Brighton, East Sussex, UK
    Anaesthesia 64:1061-5. 2009
    ..06). Renal impairment is common in patients admitted for fixation of fractured neck of femur, who are consequently at risk of opioid toxicity...
  92. ncbi Analgesia delivery in the ED
    Paul S Grant
    Department of Medicine, Royal Sussex County Hospital, Brighton, BN2 5BE, UK
    Am J Emerg Med 24:806-9. 2006
    The aim of this study was to evaluate the effectiveness of analgesia delivery, in the emergency department setting, to patients presenting with acute pain, with regard to guidelines from the British Association of Accident and Emergency ..
  93. ncbi NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain
    Kristin E Smith
    Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Behav Brain Res 232:93-7. 2012
    ..two major neurotensin receptors, NTS1 and NTS2, to elicit effects similar to those of endogenous NT, including analgesia. Previous data strongly suggest NTS2 as the main receptor involved in NT- and NT analog-mediated visceral ..
  94. ncbi Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance
    Yehuda Shavit
    Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem 91905, Israel
    Pain 115:50-9. 2005
    ..We report that administration of a neutral dose of IL-1beta abolished morphine analgesia in mice, whereas acute or chronic blockade of IL-1 signaling by various IL-1 blockers (IL-1 receptor antagonist (..
  95. ncbi Dexamethasone added to mepivacaine prolongs the duration of analgesia after supraclavicular brachial plexus blockade
    Simon J Parrington
    Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Reg Anesth Pain Med 35:422-6. 2010
    ..We hypothesized that the addition of dexamethasone to mepivacaine would prolong the duration of analgesia after ultrasound-guided supraclavicular brachial plexus block for patients undergoing upper-limb surgery.
  96. ncbi Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer
    Argyro Fassoulaki
    Department of Anesthesiology, Aretaieion Hospital, Medical School, University of Athens, Athens, Greece
    Anesth Analg 101:1427-32. 2005
    We evaluated the effect of multimodal analgesia on acute and chronic pain after breast surgery for cancer...
  97. ncbi Sex and gender differences in pain and analgesia
    Jeffrey S Mogil
    Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada
    Prog Brain Res 186:141-57. 2010
    ..Although not yet able to affect clinical practice, the continued study of sex differences in pain may have important implications for the development of new analgesic strategies...
  98. ncbi Changes in morphine analgesia and side effects during daily subcutaneous administration in healthy volunteers
    Karin Lottrup Petersen
    Department of Neurology, UCSF Pain Clinical Research Center, University of San Francisco, CA, USA
    Pain 137:395-404. 2008
    ..As 4 days is the threshold for demonstrating analgesic tolerance to twice-daily morphine in animal models, a longer period of opioid exposure in healthy volunteers might be needed to detect analgesic tolerance...
  99. ncbi Randomized prospective study comparing preoperative epidural and intraoperative perineural analgesia for the prevention of postoperative stump and phantom limb pain following major amputation
    C Cosgrove
    Vascular Surgery Unit and Department of Anaesthesia, Derriford Hospital, Plymouth, United Kingdom
    Reg Anesth Pain Med 26:316-21. 2001
    ..Epidural analgesia before limb amputation is commonly used to reduce postamputation acute stump pain in the immediate postoperative ..
  100. ncbi Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol)
    Garry G Graham
    Department of Physiology and Pharmacology, School of Medical Sciences, Faculty of Medicine, Sydney, 2052, Australia
    Curr Pharm Des 8:1063-75. 2002
    ..No such associations have been made with acetaminophen, possibly because it is a weak inhibitor of COX-1 in platelets...
  101. ncbi Extrasegmental analgesia of heterotopic electroacupuncture stimulation on visceral pain rats
    Jianhua Liu
    Guangzhou University of Traditional Chinese Medicine, 12 Jichang Road, Guangzhou 510006, PR China
    Brain Res 1373:160-71. 2011
    ..However, the underlying mechanism still remains unknown. In the present study, extrasegmental analgesia of electroacupuncture (EA) at orofacial acupoints on visceral pain rats was investigated...

Research Grants70

  1. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..acid (AJA), a non-psychotropic endocannabinoid mimetic has been shown to be highly effective in models of analgesia, inflammation and most recently fibrotic diseases...
  2. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..express key ion channels that are implicated in somatic and visceral pain (TrpV1, TrpA1), and GFLs can produce analgesia and hyperalgesia. We will delineate genes expressed in Ret-positive DRG sensory neurons...
  3. Pain and Hypoxia in Premature Neonates
    DANILYN MAG AKAT ANGELES; Fiscal Year: 2012
    ..NIH-funded neonatal pain research currently focuses primarily on the relationship between pain, analgesia, and neurodevelopmental outcomes...
  4. Molecular control of differential peptide transmitter exocytosis.
    COREY B SMITH; Fiscal Year: 2013
    ..Together they regulate multiple processes that prepare for defense or escape, including generalized analgesia (enkephalin), increased cardiac output (elevated catecholamines), blood flow to skeletal muscle (atrial ..
  5. Multivalent Vaccine for Opiate Addiction
    Paul R Pentel; Fiscal Year: 2012
    ..Aim 3 will provide rapid-throughput screening of pharmacokinetic and behavioral (hot plate analgesia) efficacy in mice, identify a lead MOpV, and test the hypothesis that immunogens can be combined into a single ..
  6. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..is a direct result of caring for very young children recovering from cardiac surgery without benefit of adequate analgesia. It has been my goal to causally demonstrate that adequate pain management is a matter of physiologic necessity...
  7. Improving pain and function in hip fracture
    R Sean Morrison; Fiscal Year: 2013
    ..sedation, nausea, respiratory depression) and studies suggest that older adults receive significantly less analgesia than younger adults...
  8. Vaccines for Sustainable Therapy of Opiate Addiction
    Frank M Orson; Fiscal Year: 2012
    ..2) The quality and quantity of the antibodies induced by these vaccines that can block opiate associated analgesia will also block heroin induced locomotor activity and reinstatement of heroin self administration in the rat ..
  9. Testing the feasibility of patient-controlled sedation in ventilated ICU patients
    Craig R Weinert; Fiscal Year: 2013
    ..Patient-controlled analgesia (PCA) has been widely used in care of post-operative patients since the 1980's and has demonstrated ..
  10. Effect of Articular Neurotoxin on Joint Pain and Neurochemical Signature
    Maren Lawson Mahowald; Fiscal Year: 2012
    ..In addition to behavioral measures of pain and analgesia, we will examine the neurobiological signature of acute and chronic arthritis pain by examining markers of ..
  11. P450 Epoxygenase Mechanisms of Opioid Analgesia
    LINDSAY HOUGH; Fiscal Year: 2013
    ..The goal of this proposal is to validate a new mechanism for morphine analgesia and to investigate new analgesic agents which may mimic morphine actions but lack side effects...
  12. Mechanisms underlying TMD-IBS comorbidity
    Richard J Traub; Fiscal Year: 2013
    ..The longterm hypothesis is that persistent pain combined with stress alters the endogenous analgesia system resulting in enhanced secondary hyperalgesia in close proximity to the initial painful site, but also in ..
  13. Telehealth Outreach for Chronic Back Pain
    Joseph H Atkinson; Fiscal Year: 2012
    ..Most back pain patients are not surgical candidates, and medications provide limited analgesia. Symptom control and improved function require a comprehensive approach addressing the cognitive and behavioral ..
  14. STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
    YVETTE FRANCE TACHE; Fiscal Year: 2013
    ..In the somatic pain field, there is vast literature on the phenomenon named "stress-induced analgesia"...
  15. Searching for Novel Analgesic and Anti-inflammatory Agents
    Guigen Li; Fiscal Year: 2010
    ..and anti-inflammatory agents on the market have been proven to show physiological effects, such as supraspinal analgesia, respiratory depression, miosis, euphoria, nausea, and reduced gastrointestinal motility...
  16. Virtual reality system for cancer patients'shoulder pain and psychosocial impact
    Grigore C Burdea; Fiscal Year: 2012
    ..hypothesized that it is possible to use virtual reality such that it simultaneously: 1) provides non-medication analgesia for women with chronic shoulder pain following breast surgery;2) improves their upper extremity strength/range ..
  17. Endocannabinoid modulation of pain-depressed behavior
    LAURA J SIMSELLEY; Fiscal Year: 2013
    ..To complement these behavioral measures, we will determine mechanistic characteristics of affective cannabinoid analgesia versus reward in selected brain regions such as the nucleus accumbens, a brain area implicated in reward and ..
  18. Molecular Basis of mu-Opioid Receptor Gene Regulation
    Jane Ko; Fiscal Year: 2009
    ..The critical roles of the mu-opioid receptor (MOR) in analgesia, as well as in the development of tolerance and dependence are well-established...
  19. Functional Connectivity of the Hypocretin/Orexin System
    Thomas S Kilduff; Fiscal Year: 2013
    ..Hcrt) system is a neuropeptide system involved in behavioral arousal, metabolism, addiction, stress-induced analgesia (SIA) and neuroendocrine function...
  20. Mechanisms and Consequences of Locus Coeruleus Activation
    KENICHIRO HAYASHIDA; Fiscal Year: 2013
    ..Gabapentin (GBP) is commonly used for treatment of neuropathic pain but its mechanisms for analgesia are not entirely known...
  21. (R)-flurbiprofen Substrate-Selective Inhibition of COX-2 and Analog Development
    Daniel Hermanson; Fiscal Year: 2013
    ..potent (R)-enantiomer of a 2- arylpropionic acid derivative NSAID, (R)-flurbiprofen, has been shown to provide analgesia in neuropathic pain models by increasing the levels of AEA...
  22. A Topical Host Defense Peptide Mimetic for Oral Mucositis
    Richard W Scott; Fiscal Year: 2012
    ..and alimentation and radically impair daily functioning and quality of life and may necessitate opioid analgesia, a liquid diet, I hydration and/or total parenteral nutrition and interruption of cancer therapy...
  23. Gated Carbon Nanotube Membrane Transdermal Drug Delivery
    BRUCE JACKSON HINDS; Fiscal Year: 2013
    ..fentanyl therapy could be improved by allowing a flexible dosage regimen for noninvasive patient controlled analgesia with added safety and security features...
  24. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..processing of proenkephalin (PE) is required to produce active enkephalin opioid peptides that regulate analgesia, behavior, and immune cell function...
  25. Regulation of opioid receptor function in trigeminal ganglion
    William P Clarke; Fiscal Year: 2012
    ..However, in general, the efficacy of 4 agonists to promote analgesia is weak to moderate...
  26. Mu-Opioid Effects on the Central Mechanisms that Control Breathing
    Edward J Zuperku; Fiscal Year: 2013
    ..sensitive targets is an important step in designing strategies to prevent respiratory depression during opioid analgesia. Our studies indicate that opioid-induced bradypnea does not result from activation of 5ORs in the preBvtzinger ..
  27. Opioid Activity in Endothelium in Sickle Cell Disease
    Kalpna Gupta; Fiscal Year: 2012
    ..AIM #3: Topically applied opioids in clinically relevant doses promote: [a] wound healing in sickle mice and [b] analgesia to wound associated nociception...
  28. Receptor Selective Spinal Analgesia
    James Eisenach; Fiscal Year: 2013
    ..The results may improve our treatment of chronic pain and offer a new approach to prevent chronic pain occurring after physical trauma. ..
  29. Nociceptive Role of SST and NT receptor-expressing dorsal horn neurons
    RONALD GORDON WILEY; Fiscal Year: 2013
    ..of two neuropeptides, which given intrathecally activate receptors on inhibitory SDH interneurons and produce analgesia in humans, somatostatin (SST), or anti-nociception in animals, neurotensin (NTS)...
  30. Effects of aging on primary afferent function
    RATAN BANIK; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Pain in the elderly people is often under-reported that leads to inadequate analgesia, slower recovery and poorer ambulation and function...
  31. Trajectory of Adverse events and Analgesia with Opioids in older adults - TAANGO
    Richard A Deyo; Fiscal Year: 2013
    ..to therapy for chronic non-cancer pain remains controversial because of sparse data on the trajectory of analgesia or adverse effects with long-term opioid use...
  32. Gender differences in peripheral cannabinoid mediated analgesia
    KATELYN YUEYI NIU; Fiscal Year: 2012
    ..of CB1 expression under inflammatory conditions and sex differences in peripheral cannabinoid receptor-mediated analgesia. PUBLIC HEALTH RELEVANCE: Orofacial muscle pain related to temporomandibular disorders affects approximately 10-..
  33. Analgesic technique on pain and biomarkers during sickle pain crisis
    Gailen D Marshall; Fiscal Year: 2011
    ..Therefore, the objective of this R21 proposal is to test the hypothesis that quality and method of analgesia affect the level of specific blood biomarkers and can be correlated with pain levels...
  34. Brain-targeted nanomedicine via buccal administration
    Hu Yang; Fiscal Year: 2010
    ..Its definitive CNS-mediated analgesia, well- defined opioid receptors, and in vitro and in vivo data readily available in the literature will allow us ..
  35. Cellular Pharmacology of Kappa Opiod Receptor
    Lee Yuan Liu-Chen; Fiscal Year: 2013
    ..Activation of KOPR produces analgesia, dysphoria, water diuresis, hypothermia and modulation of immune responses...
  36. GLUTAMATE-GATED CHANNELS IN CENTRAL &PERIPHERAL NEURONS
    James E Huettner; Fiscal Year: 2013
    ..of these receptors that may allow for clinical intervention to prevent excitotoxic cell death or to provide analgesia. The experiments in this proposal arise from several interesting discoveries that we made during the current ..
  37. Cannabinoid-based therapy and approaches to quantify pain in sickle cell disease
    Kalpna Gupta; Fiscal Year: 2013
    ..neurogenic inflammation contributes to pain in SCD and that cannabinoids offer the unique advantage of providing analgesia by disrupting neurogenic inflammation and nociceptor sensitization, thereby preventing central sensitization...
  38. A Portable Wound Hemostasis System Using a Hydrogel Polymeric Foam
    Edward Rodriguez; Fiscal Year: 2013
    ..of reversible hydrogel-based foam as a portable system for emergent hemostasis of abdominal wounds, local analgesia, disinfection and supplemental soft tissue stabilization will provide better and faster accessibility to initial ..
  39. Role of the Supraspinal Opioidergic Circuit in Prefrontal TMS-Induced Analgesia
    JOSEPH JEFFREY TAYLOR; Fiscal Year: 2013
    ..the risks associated with opiates is to develop therapies that reduce the opiate dose necessary to achieve analgesia. A focal, non-invasive form of brain stimulation called repetitive transcranial magnetic stimulation (rTMS) has ..
  40. Therapeutic Small Molecule Modulators of G beta gama Signaling
    Val S Goodfellow; Fiscal Year: 2011
    ..that these compounds are efficacious in animal models of heart failure, inflammation, and morphine-dependent analgesia. Califia Bio, Inc...
  41. Treatment of SLE with ajulemic acid, a non-psychoactive cannabinoid derivative
    Meggan Mackay; Fiscal Year: 2013
    ..options for musculoskeletal pain in SLE include non-steroidal anti-inflammatory medications (NSAIDS), narcotic analgesia and corticosteroids...
  42. Analgesics targeting truncated 6transmembrane exon 11 variants of MOR-1 (6TM-E11)
    Susruta Majumdar; Fiscal Year: 2013
    ..IBNtxA is an effective analgesic, with a potency 10-fold greater than morphine. This analgesia persists in the triple KO mice, but is lost in the exon 11 KO mice...
  43. Transcranial Direct Current Stimulation in the Management of Post-operative Pain
    Jeffrey J Borckardt; Fiscal Year: 2013
    ..are needed that can be used adjunctively to existing strategies with the potential to reduce reliance on opioid analgesia. Several novel brain stimulation technologies including transcranial direct current stimulation (tDCS) are ..
  44. The effects of aging on experimental models of pain inhibition and facilitation
    Joseph L Riley; Fiscal Year: 2013
    ..The pain modulatory tests will include inhibitory protocols;diffuse noxious controls and offset analgesia, and tests that involve pain facilitation;temporal summation, impaired decay of subthreshold pain (proxy for ..
  45. Mixed NOP/mu compounds and the involvement of their receptors in analgesia.
    LAWRENCE R TOLL; Fiscal Year: 2013
    ....
  46. Clinical Development of 4-Cl-KYN to Treat Pain
    RALPH SNODGRASS; Fiscal Year: 2010
    ..This receptor is important in mediating pain transmission, and drugs that block NMDA receptor produce analgesia. However, direct acting NMDA antagonists produce a number of side effects which have limited their therapeutic ..
  47. Unique Opioid Analgesics With No Addiction Liability or Dysphoria
    John A Lawson; Fiscal Year: 2011
    ..PPL-101 elicits potent analgesia with minimal effects on gastrointestinal transit, respiration, physical dependence, and diuresis...
  48. Pain in Preterm Infants: Development and Effects
    Ruth E Grunau; Fiscal Year: 2012
    ..The proposed research will continue to address effects of cumulative neonatal pain/stress and analgesia on stress regulation and neurodevelopment...
  49. Development of NMUR2 Antagonists as Novel Analgesics
    NEIL CUTSHALL; Fiscal Year: 2013
    ..There is clearly a large, unmet need for drugs that can produce analgesia with limited or no side effects...
  50. Analgesic actions of adenosine A1 receptor along axonal tracts in chronic pain
    Takahiro Takano; Fiscal Year: 2013
    ..signaling in peripheral pain pathways constitutes a novel therapeutic strategy that could provide longer-lasting analgesia than acupuncture itself...
  51. Posterior hypothalamic modulation of pain
    Janean E Holden; Fiscal Year: 2013
    ..on the development of more effective individualized clinical treatments that reduce neuropathic pain and promote analgesia in female and male adults...
  52. A Systems Neuroscience Approach for the Study of General Anesthesia
    Emery N Brown; Fiscal Year: 2011
    ..condition comprised of five behavioral states: hypnosis (loss of consciousness), amnesia (loss of memory), analgesia (loss of pain sensation), akinesia (immobility), and hemodynamic stability with control of the stress response...
  53. Predictors of Opioid Analgesic Responses and Common Endogenous Opioid Mechanisms
    John W Burns; Fiscal Year: 2013
    ..that better endogenous opioid function (larger opioid blockade effects) predict greater exogenous opioid analgesia. Aim 2 is to determine: a) the degree to which negative affect and emotion regulation traits, sex, acute pain ..
  54. Central Nervous System Delivery of Opioid Peptides
    JOHN HOEKMAN; Fiscal Year: 2012
    ..Opioid peptides administered via ICV or IT injection have also demonstrated an ability to enhance the analgesia of small molecule opioids (SMO), which could be exceptionally clinically useful in patients at risk for opioid ..
  55. Sex Differences in Acute Pain and Analgesic Responses: Psychosocial and Genetic I
    Barbara A Hastie; Fiscal Year: 2010
    ..Genetic and nongenetic contributions to sex differences in opioid analgesia, related side effects and treatment outcome have received limited attention in the field of pain research...
  56. Redesigning General Anesthesia
    Matthew A Wilson; Fiscal Year: 2013
    ..General anesthesia is a reversible, drug-induced behavioral state comprised of unconsciousness, amnesia, analgesia and immobility with stability and control of vital physiological systems...
  57. A Neural Systems Approach to Monitoring and Drug-Delivery for General Anesthesia
    PATRICK PURDON; Fiscal Year: 2009
    ..is a drug-induced, reversible condition comprised of five behavioral states: loss of consciousness, amnesia, analgesia, lack of movement, and hemodynamic stability...
  58. CANNABINOID RECEPTORS IN NEURONAL CELLS AND BRAIN
    Allyn C Howlett; Fiscal Year: 2013
    ..a target for pharmaceutical drug design for neuroprotection in stroke, muscle relaxation in spastic disorders, analgesia, metabolic energy balance, and substance abuse disorders...
  59. Mechanisms of Peripheral mGluR Modulation of Nociception
    Robert W Gereau; Fiscal Year: 2013
    ..Pharmacologic activation of mGlu2/3 promotes analgesia, and in fact mGlu2/3 activation appears to be an endogenous mechanism for the resolution of hyperalgesia...
  60. Exogenous Chemical Probes of TLR-Mediated Neuroinflammation
    HANG HUBERT YIN; Fiscal Year: 2013
    ..g. morphine, methadone, meperidine, and oxycodone) and that this opioid-induced glial response suppresses opioid analgesia, resulting in the development of opioid tolerance and dependence...
  61. Novel nAChR-Targeted Peptides
    J Michael McIntosh; Fiscal Year: 2011
    ..we propose to: Aim 1) Test the hypothesis that blocking alpha9alpha10 nAChRs is mechanistically responsible for analgesia and/or reduction of immune cell accumulation associated with nerve injury...
  62. Novel nAChR-Targeted Peptides
    J Michael McIntosh; Fiscal Year: 2013
    ..we propose to: Aim 1) Test the hypothesis that blocking alpha9alpha10 nAChRs is mechanistically responsible for analgesia and/or reduction of immune cell accumulation associated with nerve injury...
  63. GENDER AND SEX HORMONES AND OPIOID ANALGESIA
    Jon Levine; Fiscal Year: 2006
    ..showed, in postoperative dental patients, that k (kappa)-partial agonist opioids produce significantly greater analgesia in females than in males...
  64. Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department
    Polly Bijur; Fiscal Year: 2009
    ..Patient Controlled Analgesia (PCA) has been used successfully in post-operative pain management...
  65. Peripheral Nerve Blocks with Multimodal Analgesics
    Brian Williams; Fiscal Year: 2009
    ..of anesthesiology for orthopedic surgery, the past 12 years have provided remarkable advances in opioid-sparing analgesia via the regular use of peripheral nerve blocks...
  66. Neural Mechanisms Underlying Acupuncture Analgesia
    Jin Chung; Fiscal Year: 2007
    ..The present proposal describes a model of electroacupuncture (EA)- induced analgesia in ankle sprain pain...
  67. CHARACTERIZATION OF PLACENTAL OPIOID-ENHANCING FACTOR
    MARK KRISTAL; Fiscal Year: 1991
    ..in nonpregnant rats, that consumption of placenta or amniotic fluid significantly enhances opioid-mediated analgesia, although it does not, by itself, produce analgesia...
  68. OPIOID RECEPTOR SIGNAL TRANSDUCTION MECHANISMS
    KELLY STANDIFER; Fiscal Year: 2000
    APPLICANT'S ABSTRACT: The kappa3 opioid receptor is one of several opioid receptors mediating analgesia through a supraspinal mechanism...
  69. ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACH
    Andrea Hohmann; Fiscal Year: 2007
    ..activate neural systems that inhibit pain responsiveness, thereby inducing a phenomenon known as stress-induced analgesia (SIA)...
  70. NONPHARMACOLOGIC ANALGESIA FOR INVASIVE PROCEDURES
    Elvira Lang; Fiscal Year: 2005
    ..We propose nonpharmacologic analgesia for safe management of cognitive and physiologic distress during and after procedures...