vitamin d

Summary

Summary: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.

Top Publications

  1. ncbi Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  2. doi Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline
    Michael F Holick
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 96:1911-30. 2011
  3. doi A pooled analysis of vitamin D dose requirements for fracture prevention
    Heike A Bischoff-Ferrari
    Center on Aging and Mobility, University of Zurich and Waid City Hospital, Zurich, Switzerland
    N Engl J Med 367:40-9. 2012
  4. pmc A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
    Genome Res 20:1352-60. 2010
  5. pmc The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know
    A Catharine Ross
    Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Clin Endocrinol Metab 96:53-8. 2011
  6. pmc The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis
    Anastassios G Pittas
    Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
    J Clin Endocrinol Metab 92:2017-29. 2007
  7. pmc Vitamin D-binding protein and vitamin D status of black Americans and white Americans
    Camille E Powe
    From the Department of Medicine, Brigham and Women s Hospital C E P, Division of Nephrology, Massachusetts General Hospital J W, H T, I B, R T, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School A H B, Division of Nephrology, Beth Israel Deaconess Medical Center D Z, S A K, and Howard Hughes Medical Institute D Z, S A K all in Boston the Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore M K E, A B Z the Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD M N and the Department of Medicine, San Francisco General Hospital and University of California, San Francisco, San Francisco N R P
    N Engl J Med 369:1991-2000. 2013
  8. ncbi Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California Los Angeles School of Medicine, 924 Westwood Boulevard, Los Angeles, CA 90024, USA
    Am J Clin Nutr 79:820-5. 2004
  9. pmc The nonskeletal effects of vitamin D: an Endocrine Society scientific statement
    Clifford J Rosen
    Tufts University School of Medicine, Boston, MA 02111, USA
    Endocr Rev 33:456-92. 2012
  10. ncbi Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
    E Hypponen
    Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, WC1N 1EH, London, UK
    Lancet 358:1500-3. 2001

Detail Information

Publications386 found, 100 shown here

  1. ncbi Vitamin D deficiency
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    N Engl J Med 357:266-81. 2007
  2. doi Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline
    Michael F Holick
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 96:1911-30. 2011
    The objective was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency.
  3. doi A pooled analysis of vitamin D dose requirements for fracture prevention
    Heike A Bischoff-Ferrari
    Center on Aging and Mobility, University of Zurich and Waid City Hospital, Zurich, Switzerland
    N Engl J Med 367:40-9. 2012
    The results of meta-analyses examining the relationship between vitamin D supplementation and fracture reduction have been inconsistent.
  4. pmc A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
    Genome Res 20:1352-60. 2010
    Initially thought to play a restricted role in calcium homeostasis, the pleiotropic actions of vitamin D in biology and their clinical significance are only now becoming apparent...
  5. pmc The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know
    A Catharine Ross
    Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Clin Endocrinol Metab 96:53-8. 2011
    This article summarizes the new 2011 report on dietary requirements for calcium and vitamin D from the Institute of Medicine (IOM)...
  6. pmc The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis
    Anastassios G Pittas
    Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
    J Clin Endocrinol Metab 92:2017-29. 2007
    Altered vitamin D and calcium homeostasis may play a role in the development of type 2 diabetes mellitus (type 2 DM)...
  7. pmc Vitamin D-binding protein and vitamin D status of black Americans and white Americans
    Camille E Powe
    From the Department of Medicine, Brigham and Women s Hospital C E P, Division of Nephrology, Massachusetts General Hospital J W, H T, I B, R T, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School A H B, Division of Nephrology, Beth Israel Deaconess Medical Center D Z, S A K, and Howard Hughes Medical Institute D Z, S A K all in Boston the Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore M K E, A B Z the Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD M N and the Department of Medicine, San Francisco General Hospital and University of California, San Francisco, San Francisco N R P
    N Engl J Med 369:1991-2000. 2013
    Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency.
  8. ncbi Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction
    Ken C Chiu
    Division of Clinical Epidemiology and Preventive Medicine, Department of Medicine, University of California Los Angeles School of Medicine, 924 Westwood Boulevard, Los Angeles, CA 90024, USA
    Am J Clin Nutr 79:820-5. 2004
    Although the role of vitamin D in type 2 diabetes is well recognized, its relation to glucose metabolism is not well studied.
  9. pmc The nonskeletal effects of vitamin D: an Endocrine Society scientific statement
    Clifford J Rosen
    Tufts University School of Medicine, Boston, MA 02111, USA
    Endocr Rev 33:456-92. 2012
    Significant controversy has emerged over the last decade concerning the effects of vitamin D on skeletal and nonskeletal tissues...
  10. ncbi Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study
    E Hypponen
    Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, WC1N 1EH, London, UK
    Lancet 358:1500-3. 2001
    Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes.
  11. pmc 25-hydroxyvitamin D levels and the risk of mortality in the general population
    Michal L Melamed
    Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann 615, Bronx, NY 10461, USA
    Arch Intern Med 168:1629-37. 2008
    In patients undergoing dialysis, therapy with calcitriol or paricalcitol or other vitamin D agents is associated with reduced mortality...
  12. ncbi Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
    Michael F Holick
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Am J Clin Nutr 79:362-71. 2004
    The purpose of this review is to put into perspective the many health benefits of vitamin D and the role of vitamin D deficiency in increasing the risk of many common and serious diseases, including some common cancers, type 1 diabetes, ..
  13. pmc 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study
    Edward Giovannucci
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 168:1174-80. 2008
    b>Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans.
  14. pmc Vitamin D and type 2 diabetes: a systematic review
    J Mitri
    Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, USA
    Eur J Clin Nutr 65:1005-15. 2011
    b>Vitamin D may modify the risk of type 2 diabetes mellitus. The aim of this review was to examine the association between vitamin D status and incident type 2 diabetes, and the effect of vitamin D supplementation on glycemic outcomes.
  15. ncbi Overview of general physiologic features and functions of vitamin D
    Hector F DeLuca
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706 1544, USA
    Am J Clin Nutr 80:1689S-96S. 2004
    ..This overview provides a brief description of the physiologic, endocrinologic, and molecular biologic characteristics of vitamin D. It also provides information on new selective analogs of 1alpha,25-dihydroyvitamin D3 for therapy.
  16. pmc MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy
    Philip T Liu
    Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California, USA
    Nat Med 18:267-73. 2012
    ..as indirectly upregulating interleukin-10 (IL-10), hsa-mir-21 inhibited expression of the genes encoding two vitamin D-dependent antimicrobial peptides, CAMP and DEFB4A. Conversely, knockdown of hsa-mir-21 in M...
  17. pmc Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis
    Mark J Bolland
    Department of Medicine, University of Auckland, Private Bag 92 019, Auckland 1142, New Zealand
    BMJ 342:d2040. 2011
    ..the effects of personal calcium supplement use on cardiovascular risk in the Women's Health Initiative Calcium/Vitamin D Supplementation Study (WHI CaD Study), using the WHI dataset, and to update the recent meta-analysis of calcium ..
  18. ncbi Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
    Joan M Lappe
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 85:1586-91. 2007
    Numerous observational studies have found supplemental calcium and vitamin D to be associated with reduced risk of common cancers. However, interventional studies to test this effect are lacking.
  19. doi Prevention of rickets and vitamin D deficiency in infants, children, and adolescents
    Carol L Wagner
    American College of Obstetrics and Gynecology
    Pediatrics 122:1142-52. 2008
    Rickets in infants attributable to inadequate vitamin D intake and decreased exposure to sunlight continues to be reported in the United States. There are also concerns for vitamin D deficiency in older children and adolescents...
  20. doi 25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies
    Peter Brøndum-Jacobsen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    Arterioscler Thromb Vasc Biol 32:2794-802. 2012
    ..We tested the hypothesis that reduced plasma 25-hydroxyvitamin D associates with increased risk of ischemic heart disease, myocardial infarction, and early death...
  21. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
  22. pmc Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1
    Yong Zhang
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Immunol 188:2127-35. 2012
    It is estimated that 1 billion people around the world are vitamin D deficient. Vitamin D deficiency has been linked to various inflammatory diseases...
  23. doi Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis
    P S George
    Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Diabet Med 29:e142-50. 2012
    To systematically review the evidence for the effect of vitamin D supplementation on glycaemia, insulin resistance, progression to diabetes and complications of diabetes.
  24. ncbi High prevalence of vitamin D inadequacy and implications for health
    Michael F Holick
    Vitamin D, Skin and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, Mass 02118, USA
    Mayo Clin Proc 81:353-73. 2006
    During the past decade, major advances have been made in vitamin D research that transcend the simple concept that vitamin D is Important for the prevention of rickets in children and has little physiologic relevance for adults...
  25. ncbi Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications
    P Lips
    Department of Endocrinology, Institute for Endocrinology, Reproduction and Metabolism, EVM Institute, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
    Endocr Rev 22:477-501. 2001
    b>Vitamin D deficiency is common in the elderly, especially in the housebound and in geriatric patients. The establishment of strict diagnostic criteria is hampered by differences in assay methods for 25-hydroxyvitamin D...
  26. ncbi Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials
    Philippe Autier
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Arch Intern Med 167:1730-7. 2007
    Ecological and observational studies suggest that low vitamin D status could be associated with higher mortality from life-threatening conditions including cancer, cardiovascular disease, and diabetes mellitus that account for 60% to 70% ..
  27. pmc Systematic review: Vitamin D and cardiometabolic outcomes
    Anastassios G Pittas
    Tufts Medical Center and Friedman School of Nutrition Science and Policy, and Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Ann Intern Med 152:307-14. 2010
    b>Vitamin D may modify risk for cardiometabolic outcomes (type 2 diabetes, hypertension, or cardiovascular disease).
  28. doi Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene
    Wim Janssens
    Respiratory Division, University Hospital Gasthuisberg, KUL Herestraat 49, 3000 Leuven, Belgium
    Thorax 65:215-20. 2010
    b>Vitamin D deficiency has been associated with many chronic illnesses, but little is known about its relationship with chronic obstructive pulmonary disease (COPD).
  29. ncbi Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey
    David Martins
    Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, Calif, 90262, USA
    Arch Intern Med 167:1159-65. 2007
    Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D.
  30. doi Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality
    Harald Dobnig
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Arch Intern Med 168:1340-9. 2008
    ..This study aimed to determine whether endogenous 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels are related to all-cause and cardiovascular mortality...
  31. doi Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer
    Pamela J Goodwin
    Mount Sinai Hospital, 1284 600 University Ave, Toronto, Ontario M5G 1X4, Canada
    J Clin Oncol 27:3757-63. 2009
    b>Vitamin D has been linked to breast cancer risk, but prognostic effects are unknown...
  32. pmc Vitamin D deficiency in obese children and its relationship to glucose homeostasis
    Micah L Olson
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 97:279-85. 2012
    The aim of the study was to compare the prevalence of vitamin D deficiency in obese and non-overweight children in North Texas, to examine relationships between dietary habits and 25-hydroxyvitamin D [25(OH)D] level in obese children, ..
  33. pmc Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis
    Laura Tripkovic
    Department of Nutrition and Metabolism, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
    Am J Clin Nutr 95:1357-64. 2012
    ..Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising of serum 25-hydroxyvitamin D [25(OH)D]...
  34. doi Antibacterial effects of vitamin D
    Martin Hewison
    Department of Orthopaedic Surgery, Room 410D, Orthopaedic Hospital Research Center, 615 Charles E Young Drive South, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Nat Rev Endocrinol 7:337-45. 2011
    Interaction between vitamin D and the immune system has been recognized for many years, but its relevance to normal human physiology has only become evident in the past 5 years...
  35. doi Dose response to vitamin D supplementation in postmenopausal women: a randomized trial
    J Christopher Gallagher
    Bone Metabolism Unit, Creighton University School of Medicine, Omaha, Nebraska 68131, USA
    Ann Intern Med 156:425-37. 2012
    Serum 25-hydroxyvitamin D (25-[OH]D) is considered the best biomarker of clinical vitamin D status.
  36. pmc Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment
    Anna K Coussens
    Division of Mycobacterial Research, Medical Research Council National Institute for Medical Research, London, United Kingdom
    Proc Natl Acad Sci U S A 109:15449-54. 2012
    Calcidiol, the major circulating metabolite of vitamin D, supports induction of pleiotropic antimicrobial responses in vitro...
  37. ncbi Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K66, Atlanta, GA 30341, USA
    Diabetes Care 28:1228-30. 2005
  38. pmc Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials
    Lars Rejnmark
    Dr Med Sc, AssociateAarhus University, Department of Endocrinology and Internal Medicine, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 97:2670-81. 2012
    b>Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected...
  39. ncbi A single dose of vitamin D enhances immunity to mycobacteria
    Adrian R Martineau
    Centre for Health Sciences, Queen Mary s School of Medicine and Dentistry, Barts and The London, and Department of Clinical Biochemistry, North West London Hospitals NHS Trust, Northwick Park Hospital, Harrow, E1 2AT, UK
    Am J Respir Crit Care Med 176:208-13. 2007
    b>Vitamin D was used to treat tuberculosis (TB) in the preantibiotic era. Prospective studies to evaluate the effect of vitamin D supplementation on antimycobacterial immunity have not previously been performed.
  40. pmc Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness
    Bruce W Hollis
    Division of Neonatology and Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Bone Miner Res 26:2341-57. 2011
    The need, safety, and effectiveness of vitamin D supplementation during pregnancy remain controversial...
  41. ncbi Is vitamin D deficiency to blame for the asthma epidemic?
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 120:1031-5. 2007
    ..prosperous, more time is spent indoors, and there is less exposure to sunlight, leading to decreased cutaneous vitamin D production...
  42. pmc Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey
    Adit A Ginde
    Emergency Medicine Network, Massachusetts General Hospital, 326 Cambridge Street, Boston, MA 02114, USA
    Arch Intern Med 169:384-90. 2009
    Recent studies suggest a role for vitamin D in innate immunity, including the prevention of respiratory tract infections (RTIs)...
  43. ncbi Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease
    A Levin
    Department of Nephrology, University of British Columbia, Vancouver, BC, Canada
    Kidney Int 71:31-8. 2007
    ..Blood for parathyroid hormone (PTH), vitamin D metabolites, creatinine, calcium (Ca), and phosphorus (P) were drawn between June and October 2004...
  44. ncbi Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey
    Robert Scragg
    School of Population Health, University of Auckland, Private Bag, Auckland, New Zealand
    Diabetes Care 27:2813-8. 2004
    ..To determine the association between serum 25-hydroxyvitamin D (25OHD) and diabetes risk and whether it varies by ethnicity...
  45. pmc Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000
    Nita G Forouhi
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 57:2619-25. 2008
    ..However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study...
  46. pmc Resurrection of vitamin D deficiency and rickets
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, and Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Clin Invest 116:2062-72. 2006
    The epidemic scourge of rickets in the 19th century was caused by vitamin D deficiency due to inadequate sun exposure and resulted in growth retardation, muscle weakness, skeletal deformities, hypocalcemia, tetany, and seizures...
  47. doi Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes
    Sakineh Shab-bidar
    Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Diabetes Metab Res Rev 28:424-30. 2012
    Both vitamin D deficiency and inflammation have been linked to cardiovascular disease, the major cause of death in diabetes...
  48. pmc Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans
    Ibhar Al Mheid
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Coll Cardiol 58:186-92. 2011
    The primary objective of this study was to elucidate mechanisms underlying the link between vitamin D status and cardiovascular disease by exploring the relationship between 25-hydroxyvitamin D (25-OH D), an established marker of vitamin ..
  49. doi Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies
    Armin Zittermann
    Clinic for Thoracic and Cardiovascular Surgery, Heart Centre North Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany
    Am J Clin Nutr 95:91-100. 2012
    Low vitamin D status may increase mortality risk.
  50. pmc Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa
    Adrian R Martineau
    Division of Mycobacterial Research, National Institute of Medical Research, Mill Hill NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 108:19013-7. 2011
    b>Vitamin D deficiency is associated with susceptibility to tuberculosis (TB) in HIV-uninfected people in Europe, but it is not known whether such an association exists among HIV-infected people in subtropical Africa...
  51. doi Vitamin D controls T cell antigen receptor signaling and activation of human T cells
    Marina Rode von Essen
    Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Nat Immunol 11:344-9. 2010
    ..Induction of PLC-gamma1 was dependent on vitamin D and expression of the vitamin D receptor (VDR)...
  52. doi High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial
    An Lehouck
    University Hospitals Leuven, Belgium
    Ann Intern Med 156:105-14. 2012
    ..Because many patients with chronic obstructive pulmonary disease (COPD) have vitamin D deficiency, effects of vitamin D supplementation may extend beyond preventing osteoporosis.
  53. ncbi Activated injectable vitamin D and hemodialysis survival: a historical cohort study
    Ming Teng
    Fresenius Medical Care North America, Lexington, Massachusetts, USA
    J Am Soc Nephrol 16:1115-25. 2005
    ..ESRD commonly experience secondary hyperparathyroidism, a condition primarily managed with activated injectable vitamin D. The biologic effects of vitamin D, however, are widespread, and it is possible that activated injectable ..
  54. pmc Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age
    Carlos A Camargo
    Center for D receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Nutr 85:788-95. 2007
    b>Vitamin D deficiency and asthma are common at higher latitudes. Although vitamin D has important immunologic effects, its relation with asthma is unknown.
  55. doi Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice
    Jean Claude Souberbielle
    Laboratoire de Physiologie, CHU Necker, Paris, France
    Autoimmun Rev 9:709-15. 2010
    There is increasing evidence that, in addition to the well-known effects on musculoskeletal health, vitamin D status may be related to a number of non-skeletal diseases...
  56. doi Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis
    Mohamed B Elamin
    Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 96:1931-42. 2011
    Several studies found association between vitamin D levels and hypertension, coronary artery calcification, and heart disease.
  57. doi Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers
    Armin Zittermann
    Klinik für Thorax und Kardiovaskularchirurgie and Institut für Laboratoriums und Transfusionsmedizin, Herzzentrum NRW, Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Am J Clin Nutr 89:1321-7. 2009
    High blood concentrations of parathyroid hormone and low concentrations of the vitamin D metabolites 25-hydroxyvitamin D [25(OH)D] and calcitriol are considered new cardiovascular disease risk markers...
  58. pmc Vitamin D status: measurement, interpretation, and clinical application
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, MA, USA
    Ann Epidemiol 19:73-8. 2009
    b>Vitamin D, the sunshine vitamin, is now recognized not only for its importance in promoting bone health in children and adults but also for other health benefits, including reducing the risk of chronic diseases such as autoimmune ..
  59. doi Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study
    Rolf Jorde
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    Am J Epidemiol 171:903-8. 2010
    ..and 2008 Tromsø surveys and 2) every third month for 1 year in 94 subjects randomly assigned to placebo in a vitamin D intervention study...
  60. pmc Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
    H A Bischoff-Ferrari
    Centre on Aging and Mobility, University of Zurich, Switzerland
    BMJ 339:b3692. 2009
    To test the efficacy of supplemental vitamin D and active forms of vitamin D with or without calcium in preventing falls among older individuals.
  61. pmc Vitamin effects on the immune system: vitamins A and D take centre stage
    J Rodrigo Mora
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 8:685-98. 2008
    ..Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity...
  62. pmc Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001-2004
    Juhi Kumar
    Children s Hospital at Montefiore, Bronx, New York, USA
    Pediatrics 124:e362-70. 2009
    ..To determine the prevalence of 25-hydroxyvitamin D (25[OH]D) deficiency and associations between 25(OH)D deficiency and cardiovascular risk factors in children and adolescents...
  63. doi Vitamin D: a pleiotropic hormone
    Annemieke Verstuyf
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    Kidney Int 78:140-5. 2010
    The secosteroid hormone 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is the natural ligand for the vitamin D receptor, a member of the nuclear receptor superfamily...
  64. doi Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma
    Carlos A Camargo
    Center for D receptor Activation Research, Massachusetts General Hospital, 326 Cambridge St, Suite 410, Boston, MA 02114, USA
    Pediatrics 127:e180-7. 2011
    Higher maternal intake of vitamin D during pregnancy is associated with a lower risk of wheezing in offspring. The relationship between cord-blood levels of 25-hydroxyvitamin D (25[OH]D) and childhood wheezing is unknown...
  65. doi Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events
    Lu Wang
    Brigham and Women s Hospital and Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Ann Intern Med 152:315-23. 2010
    b>Vitamin D and calcium may affect the cardiovascular system independently and interactively.
  66. ncbi Vitamin D: A millenium perspective
    Michael F Holick
    Vitamin D Laboratory, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Cell Biochem 88:296-307. 2003
    b>Vitamin D is one of the oldest hormones that have been made in the earliest life forms for over 750 million years. Phytoplankton, zooplankton, and most plants and animals that are exposed to sunlight have the capacity to make vitamin D...
  67. pmc Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies
    Lu Wang
    Brigham and Women s Hospital, Boston, MA 02215, USA
    Circ Cardiovasc Qual Outcomes 5:819-29. 2012
    b>Vitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear.
  68. pmc Vitamin D, cognition, and dementia: a systematic review and meta-analysis
    Cynthia Balion
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
    Neurology 79:1397-405. 2012
    To examine the association between cognitive function and dementia with vitamin D concentration in adults.
  69. ncbi Vitamin D2 is much less effective than vitamin D3 in humans
    Laura A G Armas
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 89:5387-91. 2004
    ..physicians commonly report equivocal responses to seemingly large doses of the only high-dose calciferol (vitamin D(2)) available in the U.S. market...
  70. pmc Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial
    Joanna Mitri
    Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center, Boston, MA 02111, USA
    Am J Clin Nutr 94:486-94. 2011
    A suboptimal vitamin D and calcium status has been associated with higher risk of type 2 diabetes in observational studies, but evidence from trials is lacking.
  71. pmc Vitamin D levels, lung function, and steroid response in adult asthma
    E Rand Sutherland
    Department of Medicine, University of Colorado, Denver, Colorado, USA
    Am J Respir Crit Care Med 181:699-704. 2010
    Patients with asthma exhibit variable response to inhaled corticosteroids (ICS). Vitamin D is hypothesized to exert effects on phenotype and glucocorticoid (GC) response in asthma.
  72. doi Oral active vitamin D is associated with improved survival in hemodialysis patients
    Manuel Naves-Díaz
    Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto Reina Sofia de Investigacion, REDinREN del ISCIII, Universidad de Oviedo, Julian Claveria s n, 33006 Oviedo, Spain
    Kidney Int 74:1070-8. 2008
    Injection of active vitamin D is associated with better survival of patients receiving chronic hemodialysis...
  73. pmc Update in vitamin D
    John S Adams
    UCLA Orthopaedic Hospital Research Center, 615 Charles Young Drive South, Room 410E, Los Angeles, California 90095 7358, USA
    J Clin Endocrinol Metab 95:471-8. 2010
    The past decade, particularly the last 18 months, witnessed a vigorous increase in interest in vitamin D from both the lay and biomedical worlds...
  74. doi Vitamin D deficiency in children and its management: review of current knowledge and recommendations
    Madhusmita Misra
    Pediatric Endocrine and Neuroendocrine Units, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pediatrics 122:398-417. 2008
    Given the recent spate of reports of vitamin D deficiency, there is a need to reexamine our understanding of natural and other sources of vitamin D, as well as mechanisms whereby vitamin D synthesis and intake can be optimized...
  75. pmc Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts
    Karani S Vimaleswaran
    Centre for Paediatric Epidemiology and Biostatistics and MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, United Kingdom
    PLoS Med 10:e1001383. 2013
    Obesity is associated with vitamin D deficiency, and both are areas of active public health concern...
  76. pmc 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults
    Kristen L Jablonski
    Department of Integrative Physiology, University of Colorado, Boulder, Colo 80309, USA
    Hypertension 57:63-9. 2011
    ..hypothesis that vascular endothelial function, assessed by endothelium-dependent dilation, is related to serum vitamin D status among middle-aged and older adults without clinical disease, and that this is linked to inflammation...
  77. ncbi High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India
    Alok Sachan
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Am J Clin Nutr 81:1060-4. 2005
    b>Vitamin D deficiency is prevalent in India, a finding that is unexpected in a tropical country with abundant sunshine. Vitamin D deficiency during pregnancy has important implications for the newborn and infant...
  78. ncbi Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors
    Elina Hypponen
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom
    Am J Clin Nutr 85:860-8. 2007
    Increased awareness of the importance of vitamin D to health has led to concerns about the prevalence of hypovitaminosis D in many parts of the world.
  79. ncbi Relationship between serum 25-hydroxyvitamin d and pulmonary function in the third national health and nutrition examination survey
    Peter N Black
    Department of Medicine, University of Auckland, Private Bag 92019 Auckland, New Zealand
    Chest 128:3792-8. 2005
    ..Low concentrations of vitamin D have been associated with a number of diseases, including osteoporosis, hypertension, and type I diabetes...
  80. doi Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis
    Kelechi E Nnoaham
    Department of Public Health, Oxfordshire Primary Care Trust, Richard Building, Old Road Campus, Headington, Oxford OX3 7LG, UK
    Int J Epidemiol 37:113-9. 2008
    To explore the association between low serum vitamin D and risk of active tuberculosis in humans.
  81. doi Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency
    Sigrid Hatse
    Laboratory of Experimental Oncology LEO, Department of Oncology, KU Leuven, University Hospitals Leuven, Leuven Cancer Institute, Belgium
    Carcinogenesis 33:1319-26. 2012
    ..and clinical disease outcome in breast cancer patients and assessed the impact of genetic determinants of vitamin D insufficiency...
  82. pmc Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies
    Yiqing Song
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Diabetes Care 36:1422-8. 2013
    To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes.
  83. pmc Identification of microRNA-98 as a therapeutic target inhibiting prostate cancer growth and a biomarker induced by vitamin D
    Huei Ju Ting
    Department of Urology, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 288:1-9. 2013
    The anti-tumor effect of vitamin D has been well recognized but its translational application is hindered by side effects induced by supra-physiological concentration of vitamin D required for cancer treatment...
  84. doi Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence
    Pawel Pludowski
    Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children s Memorial Health Institute, Warsaw, Poland
    Autoimmun Rev 12:976-89. 2013
    Optimal vitamin D intake and its status are important not only for bone and calcium-phosphate metabolism, but also for overall health and well-being...
  85. pmc Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials
    Evropi Theodoratou
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK
    BMJ 348:g2035. 2014
    To evaluate the breadth, validity, and presence of biases of the associations of vitamin D with diverse outcomes.
  86. pmc Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease
    Martin H de Borst
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 22:1603-9. 2011
    There is increasingly evidence that the interactions between vitamin D, fibroblast growth factor 23 (FGF-23), and klotho form an endocrine axis for calcium and phosphate metabolism, and derangement of this axis contributes to the ..
  87. ncbi Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial
    Stefanie S Schleithoff
    Institute of Nutrition and Food Science, University of Bonn, Bonn, Germany
    Am J Clin Nutr 83:754-9. 2006
    ..In vitro studies suggest that vitamin D suppresses proinflammatory cytokines and increases antiinflammatory cytokines.
  88. doi The vitamin D status of Canadians relative to the 2011 Dietary Reference Intakes: an examination in children and adults with and without supplement use
    Susan J Whiting
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
    Am J Clin Nutr 94:128-35. 2011
    The 2011 Dietary Reference Intakes (DRIs) for vitamin D use 25-hydroxyvitamin D [25(OH)D] concentrations to define vitamin D deficiency (<30 nmol/L), the Estimated Average Requirement (40 nmol/L), and the Recommended Dietary Allowance ..
  89. pmc Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adults
    Jennifer L Rosenblum
    Massachusetts General Hospital Weight Center and Gastrointestinal Unit, Massachusetts General Hospital, Boston, USA
    Am J Clin Nutr 95:101-8. 2012
    Several studies suggest that calcium and vitamin D (CaD) may play a role in the regulation of abdominal fat mass.
  90. pmc Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1624-31. 2011
    b>Vitamin D deficiency (25-hydroxyvitamin D [25(OH)D] <50 nmol/L) is commonly reported in both children and adults worldwide, and growing evidence indicates that vitamin D deficiency is associated with many extraskeletal chronic ..
  91. pmc Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women's Health Initiative (WHI) limited-access data set
    Mark J Bolland
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Am J Clin Nutr 94:1144-9. 2011
    Frequent use of personal, nonprotocol calcium supplements obscured an adverse effect of coadministered calcium and vitamin D (CaD) on cardiovascular risk in the Women's Health Initiative (WHI).
  92. doi Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis
    Ann Burgaz
    Institute of Environmental Medicine, Karolinska Institiute, Stockholm, Sweden
    J Hypertens 29:636-45. 2011
    Increasing evidence indicates that vitamin D may influence the risk of hypertension, which is a major risk factor for cardiovascular disease...
  93. ncbi Calcium/vitamin D supplementation and cardiovascular events
    Judith Hsia
    Department of Medicine, George Washington University, Washington, DC, USA
    Circulation 115:846-54. 2007
    ..We evaluated the risk of coronary and cerebrovascular events in the Women's Health Initiative randomized trial of calcium plus vitamin D supplementation.
  94. ncbi Low vitamin D status despite abundant sun exposure
    N Binkley
    University of Wisconsin Osteoporosis Research Program, Madison, WI 53705, USA
    J Clin Endocrinol Metab 92:2130-5. 2007
    Lack of sun exposure is widely accepted as the primary cause of epidemic low vitamin D status worldwide...
  95. doi Global vitamin D status and determinants of hypovitaminosis D
    A Mithal
    Indraprastha Apollo Hospitals, Sarita Vihar, Delhi Mathura Road, 110044 New Delhi, India
    Osteoporos Int 20:1807-20. 2009
    This review describes the vitamin D status in different regions of the world with the objective of understanding the scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of ..
  96. pmc Nonclassic actions of vitamin D
    Daniel Bikle
    Veterans Affairs Medical Center 111N, 4150 Clement Street, San Francisco, California 94121, USA
    J Clin Endocrinol Metab 94:26-34. 2009
    b>Vitamin D receptors are found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney...
  97. doi Prevalence and correlates of vitamin D deficiency in US adults
    Kimberly Y Z Forrest
    Department of Public Health and Social Work, Slippery Rock University of Pennsylvania, Slippery Rock, PA 16057, USA
    Nutr Res 31:48-54. 2011
    Mounting evidence suggests that vitamin D deficiency could be linked to several chronic diseases, including cardiovascular disease and cancer...
  98. ncbi Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
    Kristin K Deeb
    Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Nat Rev Cancer 7:684-700. 2007
    Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers...
  99. pmc Genome-wide association study of circulating vitamin D levels
    Jiyoung Ahn
    Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA
    Hum Mol Genet 19:2739-45. 2010
    The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer...
  100. ncbi FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis
    Takashi Shimada
    Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, Takasaki, Gumma, Japan
    J Bone Miner Res 19:429-35. 2004
    ..FGF-23 caused a reduction in serum 1,25-dihydroxyvitamin D by altering the expressions of key enzymes for the vitamin D metabolism followed by hypophosphatemia...
  101. pmc Vitamin D and human health: lessons from vitamin D receptor null mice
    Roger Bouillon
    Katholieke Universiteit Leuven, Laboratory of Experimental Medicine and Endocrinology, Herestraat 49, O and N 1 bus 902, 3000 Leuven, Belgium
    Endocr Rev 29:726-76. 2008
    The vitamin D endocrine system is essential for calcium and bone homeostasis...

Research Grants83

  1. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..osteoporosis, on fat and calcium absorption, and on the status of fat soluble vitamins (A, K, E, and 25-hydroxy vitamin D metabolites) and other toxicological effects in Sprague-Dawley rats...
  2. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..osteoporosis, on fat and calcium absorption, and on the status of fat soluble vitamins (A, K, E, and 25-hydroxy vitamin D metabolites) and other toxicological effects in Sprague-Dawley rats...
  3. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..leptin, resistin, liver function enzymes);(3) renal function (creatinine, cystatin C, ADMA, uric acid, 25(OH)vitamin D, parathyroid hormone);and (4) inflammation and hemostasis (hsCRP, MCP-1, IL-6, sTNFRII, sVCAM-1, sICAM-1, serum ..
  4. Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate Cancer
    Bandana Chatterjee; Fiscal Year: 2013
    ..b>Vitamin D deficiency is a common problem among the elderly...
  5. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ..and that of an adolescent human female with a similar phenotype led us to the discovery of a novel means for vitamin D and estrogen resistance in primates, including man...
  6. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Vitamin D deficiency is much more common in African Americans than whites...
  7. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..FOXP3 and IL-17 gene regulation through identifying and characterizing the binding site(s) of the vitamin D receptor in the human FOXP3 and IL-17 genes...
  8. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ..These studies will provide proof of principle of this concept and establish the bioassay through study of vitamin D and genomic stability...
  9. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids. Cyts P450 exists in virtually every organ and tissue of humans...
  10. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..The current modalities for treatment of COPD are limited, and prevalence of vitamin D deficiency is high...
  11. Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
    ANNE LOUISE SCHAFER; Fiscal Year: 2013
    ..This is of critical concern given the tremendous impact of osteoporosis and fracture in both men and women. Vitamin D deficiency due to obesity and post-surgical malabsorption may partially explain the decline in bone mass ..
  12. Role of beta-endorphin in cancer therapy induced fatigue
    David E Fisher; Fiscal Year: 2013
    ..linkage may relate to evolutionary advantages of sun-seeking behaviors to maintain UV derived cutaneous vitamin D synthesis...
  13. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
    ..Cross-cutting themes are the investigation of vitamin D, inflammatory, and energy balance pathways as they relate to cancer incidence...
  14. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2013
    ..major metabolic processes including glucose, lipid, cholesterol, and bile acid metabolism, and phosphate/vitamin D homeostasis...
  15. New drug VS-110 for treating inflammatory bowel diseases
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..New agents are needed to treat UC and CD and prevent relapse. Vitamin D receptor (VDR), once activated by its endogenous hormone calcitriol (1,25(OH) 2D3), modulates signaling pathways ..
  16. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ..enzyme converting 25-hydroxyvitamin D3 to the most active form of vitamin D3, 1,25-dihydroxyvitamin D3) and the vitamin D receptor (VDR), a nuclear hormone receptor super-family member, are distributed throughout many organ systems ..
  17. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    ..b>Vitamin D receptor modulators (VDRMs) have been shown to reduce proteinuria/albuminuria in CKD patients and also provide ..
  18. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..b>Vitamin D receptor modulators (VDRMs) have been shown to reduce proteinuria/albuminuria in diabetic nephropathy patients ..
  19. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ..to leverage a newly NIH-funded large, randomized, double-blind, placebo-controlled, 2x2 factorial trial of vitamin D (in the form of vitamin D3 [cholecalciferol]) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + ..
  20. Dietary Risk for Colon Cancer in the Mouse
    Leonard H Augenlicht; Fiscal Year: 2013
    ..and our data that this cytokine is elevated by the NWD1, but that this is prevented by elevating calcium and vitamin D in NWD2, we will use a novel neutralizing monoclonal Ab to IL12 to determine whether this eliminates or ..
  21. Genetic Epidemiology of Life-Threatening Influenza Infection in Children
    Adrienne Randolph; Fiscal Year: 2009
    ..protein (RIG-I), the collectins surfactant proteins A and D (SP-A, SP-D) and mannose binding lectin (MBL), Vitamin D related genes (VDR), and genes influencing down-stream cytokines such as interferon-alpha (IFN-[unreadable]), ..
  22. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2013
    ..of postmenopausal women who fracture their hip and have no other cause for low bone mass, are deficient in vitamin D. Vitamin D deficiency can result in osteomalacia, where the mineral composition and bone tissue volume are both ..
  23. Assessment of Bone Composition Through a Novel Liquid/Solid State MRI Method
    Ara Nazarian; Fiscal Year: 2011
    ..of postmenopausal women who fracture their hip and have no other cause for low bone mass, are deficient in vitamin D. Vitamin D deficiency can result in osteomalacia, where the mineral composition and bone tissue volume are both ..
  24. EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSIS
    Devendra K Agrawal; Fiscal Year: 2013
    ..We hypothesize that obesity-induced inflammatory phenotype of epicardial fat is exacerbated by vitamin D deficiency leading to endothelial dysfunction and enhanced intimal hyperplasia following coronary intervention...
  25. VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There is a high prevalence of inadequate vitamin D levels in the United States...
  26. Maternal-fetal vitamin D status and child adiposity, insulin resistance and BP
    Susanna Y Huh; Fiscal Year: 2010
    ..Deficiency of Vitamin D, a fat-soluble hormone, may be a novel modifiable risk factor in the development of obesity and related sequelae...
  27. Vitamin D and Arterial Function in Patients with Chronic Kidney Disease
    Jessica B Kendrick; Fiscal Year: 2013
    ..fellow at the University of Colorado at Denver Health Sciences Center whose main area of interest is in vitamin D dysregulation and its relationship with all-cause mortality and cardiovascular disease (CVD) in patients with ..
  28. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..A growing body of evidence suggests that vitamin D has anti-carcinogenic effects by modulating cellular growth and apoptosis, and by reducing angiogenesis...
  29. Classical and non-classical responses to vitamin D in children: the role of DBP g
    Thomas O Carpenter; Fiscal Year: 2010
    ..80% minorities) with either low or normal circulating 25-hydroxyvitamin D (25-OHD) levels, and have found that vitamin D deficiency (circulating 25-OHD <20 ng/ml) occurs in 13% of over 750 6 mo...
  30. Lifestyle and Molecular Factors of Bone Health in Breast Cancer Survivors
    Song Yao; Fiscal Year: 2013
    ..secondary outcome) in association with 1) modifiable lifestyle factors such as physical activity, diet, vitamin D and calcium supplement use, smoking, and alcohol consumption;2) germline genetic variations in estrogen and bone ..
  31. Vitamin D and Vascular Function in Obese Children
    Kumaravel Rajakumar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vitamin D deficiency is emerging as an independent risk factor for subclinical vascular dysfunction, metabolic syndrome, and later cardiovascular disease (CVD) in children...
  32. Molecular &Cellular Effects of Human Mutations in Cytochrome P450 Reductase
    Satya Prakash Panda; Fiscal Year: 2013
    ..laboratory) bone-specific knockout mouse model using micro CT, differential staining and determination of vitamin D, retinoic acid, cholesterol, steroid, and lipid serum levels in these mice...
  33. VITAMIN D DEFICIENCY, INSULIN RESISTANCE AND CARDIOVASCULAR DISEASE
    Carlos Bernal-Mizrachi; Fiscal Year: 2013
    ..Our preliminary data indicates that vitamin D receptor signaling modulates adhesion, migration, and foam cell formation in macrophages and appears to decrease ..
  34. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2010
    ..OC), tartrate-resistant acid phosphatase 5b (TRAP-5b);nutritional markers: magnesium, vitamin K1, and 25(OH) vitamin D;and also examine other relevant biomarkers covered by the funded MS study, including steroid hormones: androgen, ..
  35. Vitamin D and fibroblast growth factor 23 physiology in adolescent girls
    DEBORAH MICHELLE MITCHELL; Fiscal Year: 2012
    ..growth factor 23 (FGF23) is a hormone with a central role in regulating circulating phosphate (Pi) levels and vitamin D metabolism...
  36. Dynamic Mechanisms of Vitamin D-Induced Gene Expression
    J Wesley Pike; Fiscal Year: 2012
    ..Despite a general description of vitamin D action on bone, the mechanisms that permit orchestration of these activities by 1,25(OH)2D3 at the genome-wide ..
  37. Diet, Biomarkers and Lung Function
    Rui Jiang; Fiscal Year: 2010
    ..lung function, lower lung density, and greater longitudinal decline in lung density in MESA;C) high intake of vitamin D and dairy products and elevated levels of 25(OH) vitamin D are associated with higher lung function, higher lung ..
  38. (PQA1) Mechanism of Vitamin D Chemoprevention Against Colon Cancer
    Yan Chun Li; Fiscal Year: 2013
    ..by which a drug that is chronically used for other indications protects against cancer incidence and mortality? Vitamin D (VD) is a widely and chronically used supplement for maintenance of bone health and for treatment of ..
  39. Vitamin D Deficiency in Glomerular Disease
    Michelle Denburg; Fiscal Year: 2013
    ..Her research is focused on the extra-skeletal actions of vitamin D and the unique challenges of managing vitamin D deficiency in patients with glomerular diseases complicated by ..
  40. Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2013
    ..erythropoietic cell signaling and the development of anemia in the elderly in the setting of the newly launched VITamin D and OmegA-3 TriaL (VITAL)...
  41. Biological &Environmental Mediators of Vitamin D and Aggressive Prostate Cancer
    ADAM BRYANT MURPHY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Murphy, Adam B. Biological and Environmental Mediators of Vitamin D and Aggressive Prostate Cancer! Candidate: Dr. Adam Murphy is an academic urologist who completed residency two years ago...
  42. Toll-like Receptor 2, Vitamin D, and Extrapulmonary Tuberculosis
    CHRISTINA A FISKE; Fiscal Year: 2013
    ..evidence suggests that pathogen recognition receptors called Toll-like receptors (TLRs), specifically TLR2, and vitamin D play a major role in the immune response to M. tuberculosis...
  43. Vitamin D in Prostate Cancer: Tumor Vasculature Effects
    Candace S Johnson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Calcitriol (vitamin D or 1,25 dihydroxycholecalciferol), a central factor in bone and mineral metabolism, has significant antitumor activity in vitro and in vivo...
  44. Pilot Study of Arsenic, UV and Melanoma in a Non-Hispanic White Population
    Janice W Yager; Fiscal Year: 2011
    ..repair capacity in melanoma and non-melanoma patients will be evaluated controlling for UV exposure and serum vitamin D levels...
  45. Participation in Cytochrome b5 in Anesthetic Metabolism
    Lucy A Waskell; Fiscal Year: 2010
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids. Cyts P450 exist in virtually every organ and tissue of humans...
  46. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2013
    ..inverse correlation between cancer mortality rates and regional solar UV-B radiation exposure, a major source of vitamin D (vit D), has been found for cancers of the breast, colon, rectum, ovary, prostate, stomach, and numerous other ..
  47. Safe and Effective Vitamin D Supplementation in HIV
    Virginia A Stallings; Fiscal Year: 2012
    The key role of vitamin D (vit D) in maintaining optimal bone health has long been recognized, but its role in modulating the innate immune response and inflammatory reaction has only recently come under active investigation...
  48. Randomized trial of active vitamin D, cholecalciferol and placebo for CKD-MBD
    Sharon M Moe; Fiscal Year: 2011
    ..parathyroid hormone for the treatment of CKD-MBD is pharmacologic preparations of the kidney activated form of vitamin D- calcitriol and analogs such as doxercalciferol...
  49. Vitamin D deficiency and treatment in male veterans at risk for diabetes
    Elena Barengolts; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Emerging evidence suggests that higher vitamin D blood levels are associated with better health outcomes including type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) but it remains ..
  50. Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on Fractures
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..by applicant): Osteoporotic fractures are major public health problems that have been associated with low vitamin D levels. Previous data strongly suggest that doses of vitamin D = 700 IU/day reduce fractures and possibly falls...
  51. Non-Classical Manifestations of Primary Hyperparathyroidism
    Shonni J Silverberg; Fiscal Year: 2013
    ..The themes and Specific Aims (SA's) of this research are: Theme 1. Vitamin D deficiency in PHPT: SA1a...
  52. Integrated Cardio-Renal Risk Prediction Models in Type 1 Diabetes
    Marian J Rewers; Fiscal Year: 2010
    ..Increased systemic inflammation is present in type 1 diabetes and inflammatory mediators such as uric acid, vitamin D and bone metabolism markers have been suggested to play a role in both renal and cardiovascular diseases...
  53. A Prospective Study of Diet and Prostate Cancer
    Edward Giovannucci; Fiscal Year: 2011
    We propose to examine four inter-related pathogenic pathways for prostate carcinogenesis: the vitamin D axis, inflammation, sex steroids, and insulin/insulin-like growth factor signaling...
  54. Regulation of Bone Mineralization in Renal Osteodystrophy
    ISIDRO BENJAMIN SALUSKY; Fiscal Year: 2012
    ..hand, fibroblast growth factor 23 (FGF-23) has an important biological role in the control of phosphate and vitamin D metabolism in individuals with normal renal function...
  55. Role of vitamin D receptor in DNA repair
    Dennis H Oh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The role of vitamin D in ameliorating various health outcomes other than bone-related metabolism is controversial...
  56. Milk osteopontin, a nutritional therapeutic intervention for alcoholic hepatitis
    Natalia Nieto; Fiscal Year: 2013
    ..Key events for the onset and progression of alcoholic hepatitis result from the gut-to-liver interaction. Vitamin D deficiency is highly prevalent in patients with alcoholic hepatitis...
  57. Vitamin D and the Immune System
    Lawrence Steinman; Fiscal Year: 2012
    ..the mechanisms involved will result in new concepts in our understanding of the interaction between the vitamin D endocrine system and the immune system that may suggest therapeutic targets for the control of MS and other TH17 ..
  58. Biomaterials (Mf/Zn/F-BCPs) for osteoporosis therapy
    Yu Zhang; Fiscal Year: 2012
    ..b) restoration or reversal of bone loss induced by ovariectomy or mineral deficiency, compared with calcium + vitamin D supplement;(3) evaluate the effect of MZF-CaP and MZ-CaP/FF on prevention of bone loss in a larger animal model (..
  59. Orthopaedic Wear Debris, Vitamin D, and Innate Immunity
    John S Adams; Fiscal Year: 2010
    ..and 2] innate immune signaling in primary isolates of human macrophages is mediated by TLRs and impaired by a vitamin D-insufficient status in the host. Two aims are proposed to test the above-stated hypothesis...
  60. Vitamin D, Epstein-Barr virus infection, and cigarette smoking and risk of multip
    Alberto Ascherio; Fiscal Year: 2013
    ..Converging evidence from multiple studies suggests that inadequate vitamin D nutrition, infection with the Epstein-Barr virus (EBV), and cigarette smoking are important risk factors for MS...
  61. Southern Community Cohort Study
    Wei Zheng; Fiscal Year: 2013
    ..well positioned to address, many for the first time among African Americans, including the roles of obesity, vitamin D, specific infections (Chlamydia pneumoniae, Trichomonas vaginalis, Helicobacter pylori, and xenotropic murine ..
  62. Melanoma Prevention: Using the Sun
    Marianne Berwick; Fiscal Year: 2013
    ..Examples of novel initiatives include exploration of interaction effects of sunlight and Vitamin D with the vitamin D receptor and its pathway, immunological factors and hormonal influences on both etiology and ..
  63. VITAMIN D HORMONE MECHANISM OF ACTION IN CULTURED CELLS
    MARK HAUSSLER; Fiscal Year: 1999
    This application proposes the continuation of our investigation of the molecular and biological functions of the vitamin D hormone (1,25(OH)2D3) in cultured cell systems...
  64. Supplemental Vitamin D and Functional Outcomes in Early Adolescence
    Richard D Lewis; Fiscal Year: 2010
    b>Vitamin D intakes'in children do not meet current US Dietary Reference Intake (DRI) recommendations and emerging evidence suggests that a significant number of children, particularly those with darker skin pigmentation, have ..
  65. Prevention of Vitamin D Deficiency in Breastfed Infants
    Ekhard Ziegler; Fiscal Year: 2009
    b>Vitamin D deficiency occurs among breastfed infants in all parts of the U.S. but is particularly common among infants with dark skin pigmentation and infants living in the northern parts of the U.S...
  66. OSTEOPOROSIS/DIHYDROXYVITAMIN REGULATED GENE EXPRESSION
    Sylvia Christakos; Fiscal Year: 1993
    ..in both male and female rats in the expression of two genes involved in intestinal calcium absorption and in vitamin D regulated renal handling of calcium; calbindin (the vitamin D- dependent calcium binding protein) and the ..
  67. Dose-dependent anti-inflammatory effects of vitamin D in a human gingivitis model
    Raul Garcia; Fiscal Year: 2009
    ..Data from in-vitro and animal studies suggest anti-inflammatory effects of vitamin D;however, if and over what dose-range vitamin D may have anti- inflammatory effects in humans is uncertain...
  68. VITAMIN D BINDING PROTEIN
    Nancy Cooke; Fiscal Year: 2003
    b>Vitamin D binding protein (DBP) is an abundant serum protein belonging to the multigene family that includes albumin, alpha- fetoprotein, and alpha-albumin/afamin. Multiple functions have been attributed to DBP...
  69. Claudin-2, Claudin-12 and Cadherin-17: Novel Targets of Vitamin D Action
    ANGELA R PORTA; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The object of this proposal is to obtain a better understanding of vitamin D action on intestinal calcium transport...
  70. Nutritional Intervention for Age-Related Muscular Function and Strength Losses
    John A Rathmacher; Fiscal Year: 2010
    ..These data form the basis of our current hypothesis that the combination of HMB and Vitamin D supplementation will be synergistic and will result in significant enhancements in overall muscle strength, ..
  71. Vitamin D status in pregnant women
    Theresa Scholl; Fiscal Year: 2009
    DESCRIPTION (provided by investigator): Vitamin D is present in food either naturally or by fortification and included in nutritional supplements. It is also synthesized photochemically by the skin from ultraviolet B radiation...
  72. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2003
    The main goal of this application is to define the role of vitamin D and parathyroid hormone (PTH) in the regulation of the renin-angiotensin system in vivo, which plays a crucial role in the regulation of blood pressure, electrolyte ..
  73. Relationships between Skin Pigmentation, Vitamin D and Blood Pressure
    FLOJAUNE GRIFFIN; Fiscal Year: 2009
    ..The goal of this study is to characterize the effect of skin pigmentation on serum 25- hydroxycholecalciferol (vitamin D) levels, and, in turn, ascertain their association with blood pressure among women as they age...
  74. Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
    Roberd Bostick; Fiscal Year: 2009
    ..biological plausibility and animal experimental evidence for protection against colorectal cancer by calcium and vitamin D, calcium significantly reduced adenoma recurrence in a large clinical trial, and the observational literature ..
  75. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra G Mehta; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The role of vitamin D in colorectal cancer (CRC) prevention is well recognized...
  76. Calcium, Vitamin D, and Markers of Adenomatous Polyps
    Roberd Bostick; Fiscal Year: 2006
    ..biological plausibility and animal experimental evidence for protection against colorectal cancer by calcium and vitamin D, calcium significantly reduced adenoma recurrence in a large clinical trial in humans (yet the previously ..
  77. Vitamin D Deficiency Augments Renin-Angiotensin System Activity in Obesity
    Anand Vaidya; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The overall aim of this study is to examine whether Vitamin D supplementation reduces endogenous renin-angiotensin system activity (RAS) in obesity...
  78. Genetic Variation in Vitamin D Metabolism and BMT Outcomes
    KIMBERLY ROBIEN; Fiscal Year: 2009
    ..Because of its immunomodulatory and cell cycle regulatory activities, maintaining adequate vitamin D status throughout the treatment course may decrease risk of GVHD and disease relapse, which in turn, could ..
  79. Vitamin D Control of TGFa/EFG Receptor Growth Signaling
    Adriana Dusso; Fiscal Year: 2006
    ..While it is known that hypocalcemia, hyperphosphatemia, and vitamin D deficiency promote parathyroid (PT) hyperplasia in renal failure, the underlying mechanisms are poorly ..
  80. VITAMIN D MEDIATED GENE REGULATION IN B LYMPHOCYTES
    John Morgan; Fiscal Year: 2000
    ..the Applicant's Abstract): The biological effects of 1,25-dihydroxyvitamin D (1,25D), the active metabolite of vitamin D, are assumed to be effected by interaction of the hormone with specific intracellular receptors and their ..
  81. Vitamin D induction of antibacterial activity in gingival cells
    Gill Diamond; Fiscal Year: 2009
    ..LL-37 were induced in myeloid cells and several cell lines by a less toxic agent, the hormonally active form of vitamin D, 1,25(OH)2-vitamin D3...
  82. EFFECTS OF VITAMIN D DEFICIENCY ON MALE REPRODUCTION
    GARY KWIECINSKI; Fiscal Year: 1992
    The long-term objectives of this application are to identify sites and mechanisms of action of vitamin D that are responsible for the reduced fertility observed in vitamin D deficiency...
  83. Vitamin D Receptor-Cofactor Interactions as Targets for Novel Drug Discovery
    John Norris; Fiscal Year: 2009
    The secosteroid vitamin D plays a critical role in cell differentiation, proliferation and mineral homeostasis. As such, this hormone is essential for the development and maintenance of healthy bone...