hydrocortisone

Summary

Summary: The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

Top Publications

  1. ncbi Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change
    Jens C Pruessner
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
    Psychoneuroendocrinology 28:916-31. 2003
  2. ncbi Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research
    Sally S Dickerson
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
    Psychol Bull 130:355-91. 2004
  3. ncbi 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response
    Jeremy W Tomlinson
    Endocrinology, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Endocr Rev 25:831-66. 2004
  4. pmc Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women
    Mark Hamer
    Department of Epidemiology and Public Health, University College London, London, United Kingdom
    PLoS ONE 7:e31356. 2012
  5. ncbi Stress-induced changes in human salivary alpha-amylase activity -- associations with adrenergic activity
    Urs Markus Nater
    Institute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Zürichbergstr 43, CH 8044 Zurich, Switzerland
    Psychoneuroendocrinology 31:49-58. 2006
  6. ncbi Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis
    Panagiotis Anagnostis
    Department of Clinical Biochemistry, Royal Free Hospital Campus, University College Medical School, University College London, Pond Street, London, United Kingdom
    J Clin Endocrinol Metab 94:2692-701. 2009
  7. ncbi Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
    Markus Heinrichs
    Department of Clinical Psychology, University of Zurich, Zurich, Switzerland
    Biol Psychiatry 54:1389-98. 2003
  8. ncbi If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans
    Gregory E Miller
    Department of Psychology, University of British Columbia UBC, Vancouver, BC, Canada
    Psychol Bull 133:25-45. 2007
  9. pmc Association of diurnal patterns in salivary cortisol with all-cause and cardiovascular mortality: findings from the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 96:1478-85. 2011
  10. ncbi Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis
    Yoichi Chida
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, United Kingdom
    Biol Psychol 80:265-78. 2009

Detail Information

Publications310 found, 100 shown here

  1. ncbi Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change
    Jens C Pruessner
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Canada
    Psychoneuroendocrinology 28:916-31. 2003
    ..It is shown that depending on which formula is used, different associations with other variables may emerge. Consequently, it is recommended to employ both formulas when analyzing data sets with repeated measures...
  2. ncbi Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research
    Sally S Dickerson
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
    Psychol Bull 130:355-91. 2004
    ..These findings are consistent with the animal literature on the physiological effects of uncontrollable social threat and contradict the belief that cortisol is responsive to all types of stressors...
  3. ncbi 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response
    Jeremy W Tomlinson
    Endocrinology, Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Endocr Rev 25:831-66. 2004
    ..Therapeutic inhibition of 11beta-HSD1 reductase activity in patients with obesity and the metabolic syndrome, as well as in glaucoma and osteoporosis, remains an exciting prospect...
  4. pmc Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women
    Mark Hamer
    Department of Epidemiology and Public Health, University College London, London, United Kingdom
    PLoS ONE 7:e31356. 2012
    ..We examined the association between cortisol responses to laboratory-induced mental stress and the progression of coronary artery calcification (CAC)...
  5. ncbi Stress-induced changes in human salivary alpha-amylase activity -- associations with adrenergic activity
    Urs Markus Nater
    Institute of Psychology, Clinical Psychology and Psychotherapy, University of Zurich, Zürichbergstr 43, CH 8044 Zurich, Switzerland
    Psychoneuroendocrinology 31:49-58. 2006
    ..Since it does not seem to be closely related to other biological stress markers such as catecholamines and cortisol, salivary alpha-amylase may be a useful additional parameter for the measurement of stress...
  6. ncbi Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis
    Panagiotis Anagnostis
    Department of Clinical Biochemistry, Royal Free Hospital Campus, University College Medical School, University College London, Pond Street, London, United Kingdom
    J Clin Endocrinol Metab 94:2692-701. 2009
    ..The present review summarizes the evidence on the potential role of cortisol in the pathogenesis of MetS and discusses new therapeutic approaches for these patients...
  7. ncbi Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
    Markus Heinrichs
    Department of Clinical Psychology, University of Zurich, Zurich, Switzerland
    Biol Psychiatry 54:1389-98. 2003
    ..This study was designed to determine the effects of social support and oxytocin on cortisol, mood, and anxiety responses to psychosocial stress in humans...
  8. ncbi If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans
    Gregory E Miller
    Department of Psychology, University of British Columbia UBC, Vancouver, BC, Canada
    Psychol Bull 133:25-45. 2007
    ..Finally, HPA activity is shaped by a person's response to the situation; it increases with subjective distress but is lower in persons with posttraumatic stress disorder...
  9. pmc Association of diurnal patterns in salivary cortisol with all-cause and cardiovascular mortality: findings from the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 96:1478-85. 2011
    ..Evidence for the association of cortisol with mortality or disease events is mixed, possibly due to a failure to consider diurnal cortisol patterns...
  10. ncbi Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis
    Yoichi Chida
    Psychobiology Group, Department of Epidemiology and Public Health, University College London, United Kingdom
    Biol Psychol 80:265-78. 2009
    ..This review concludes that different psychosocial factors are associated with an enhanced or reduced cortisol awakening response...
  11. ncbi Salivary cortisol as a biomarker in stress research
    Dirk H Hellhammer
    Psychology, Department of Clinical and Physiological Psychology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 34:163-71. 2009
    ....
  12. pmc Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish
    Rupert J Egan
    Stress Physiology and Research Center SPaRC, Department of Physiology and Biophysics, Georgetown University Medical School, 3900 Reservoir Road, Washington, DC 20057, USA
    Behav Brain Res 205:38-44. 2009
    ..Collectively, our results confirm zebrafish as a valid, reliable, and high-throughput model of stress and affective disorders...
  13. pmc The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline
    Lynnette K Nieman
    Program on Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 93:1526-40. 2008
    ..The objective of the study was to develop clinical practice guidelines for the diagnosis of Cushing's syndrome...
  14. ncbi Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
    C M Pariante
    Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London, United Kingdom
    Biol Psychiatry 49:391-404. 2001
    ..Further elucidation of the biochemical and molecular mechanisms involved in GR changes in major depression is an exciting frontier that will no doubt lead to new insights into the pathophysiology and treatment of affective disorders...
  15. ncbi The influence of social hierarchy on primate health
    Robert M Sapolsky
    Departments of Biological Sciences, Neurology and Neurological Sciences, Stanford University, MC 5020, Stanford, CA 94305 5020, USA
    Science 308:648-52. 2005
    ..Finally, I consider how these findings apply to the human realm of health, disease, and socioeconomic status...
  16. ncbi Depression and cortisol responses to psychological stress: a meta-analysis
    Heather M Burke
    Department of Psychiatry, University of California, San Francisco, USA
    Psychoneuroendocrinology 30:846-56. 2005
    ..This blunted reactivity-impaired recovery pattern observed among the afternoon studies was most pronounced in studies with older and more severely depressed patients...
  17. pmc 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
    Anne Hermanowski-Vosatka
    Merck Research Laboratories, Merck and Company, Rahway, NJ 07065, USA
    J Exp Med 202:517-27. 2005
    ....
  18. ncbi Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study
    Sophie A Vreeburg
    Department of Psychiatry, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    Arch Gen Psychiatry 66:617-26. 2009
    ..There is a central belief that depression is associated with hyperactivity of the hypothalamic-pituitary-adrenal axis, resulting in higher cortisol levels. However, results are inconsistent...
  19. ncbi Impact of gender, menstrual cycle phase, and oral contraceptives on the activity of the hypothalamus-pituitary-adrenal axis
    C Kirschbaum
    Center for Psychobiological and Psychosomatic Research, University of Trier, Germany
    Psychosom Med 61:154-62. 1999
    ..The aim of the present study was to investigate sex-specific HPA response patterns with a focus on the contribution of gonadal steroids as possible mediators...
  20. ncbi Relationship of subjective and objective social status with psychological and physiological functioning: preliminary data in healthy white women
    N E Adler
    Health Psychology Program, University of California, San Francisco 94143 0844, USA
    Health Psychol 19:586-92. 2000
    ..Results suggest that, in this sample with a moderately restricted range on SES and health, psychological perceptions of social status may be contributing to the SES-health gradient...
  21. ncbi Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research
    Cinnamon Stetler
    Department of Psychology, Furman University, 3300 Poinsett Hwy, Greenville, SC 29613, USA
    Psychosom Med 73:114-26. 2011
    ..These sources include methodological differences between studies, as well as demographic or clinical differences between depressed samples...
  22. ncbi Cushing's syndrome
    John Newell-Price
    Division of Clinical Sciences, University of Sheffield, Northern General Hospital, Sheffield, UK
    Lancet 367:1605-17. 2006
    ..Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches. We provide diagnostic algorithms and recommendations for management...
  23. ncbi Salivary cortisol in ambulatory assessment--some dos, some don'ts, and some open questions
    Brigitte M Kudielka
    Department of Medical Psychology and Psychological Diagnostics, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany
    Psychosom Med 74:418-31. 2012
    ..We thus discuss several important issues related to the collection and storage of saliva samples and present empirical data on the stability of salivary cortisol measurements over time...
  24. ncbi Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation
    G Johannsson
    Department of Endocrinology, Sahlgrenska Academy, University of Gothenburg, SE 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 97:473-81. 2012
    ..Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet with a more physiological exposure-time cortisol profile.
  25. pmc A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling
    Gregory E Miller
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Biol Psychiatry 64:266-72. 2008
    ..Chronic stressors are known to increase vulnerability to medical illness, but the mechanisms underlying this phenomenon are poorly understood...
  26. pmc Diurnal cortisol patterns are associated with physical performance in the Caerphilly Prospective Study
    Michael P Gardner
    School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol, UK
    Int J Epidemiol 40:1693-702. 2011
    ..We examined the relationship between repeat cortisol measures over 20 years and physical performance in later life...
  27. ncbi Assessing salivary cortisol in large-scale, epidemiological research
    Emma K Adam
    School of Education and Social Policy and Institute for Policy Research, Northwestern University, United States
    Psychoneuroendocrinology 34:1423-36. 2009
    ....
  28. pmc The combined dexamethasone/CRH Test (DEX/CRH test) and prediction of acute treatment response in major depression
    Cornelius Schule
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    PLoS ONE 4:e4324. 2009
    ..In this study the predictive value of the combined dexamethasone/CRH test (DEX/CRH test) for acute antidepressant response was investigated...
  29. ncbi The cortisol awakening response (CAR): facts and future directions
    Eva Fries
    Technische Universitat Dresden, Faculty of Science, Department of Psychology, Dresden, Germany
    Int J Psychophysiol 72:67-73. 2009
    ..The present paper reviews the current knowledge on the neural regulation of the CAR and factors influencing this phenomenon and considerations are addressed concerning the exact function of the CAR...
  30. ncbi On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders
    Theresa M Buckley
    Stanford Sleep Disorders Clinic and Research Center and Department of Psychiatry, Stanford University, 401 Quarry Road, Suite 3301, Stanford, California 94305, USA
    J Clin Endocrinol Metab 90:3106-14. 2005
    ..Mechanisms by which cortisol can affect slow wave sleep are discussed, as is the role the HPA axis plays in secondary effects of primary sleep disorders...
  31. ncbi Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
    Marcus Ising
    Max Planck Institute of Psychiatry, Munich, Germany
    Biol Psychiatry 62:47-54. 2007
    ..In the present study, we examined whether change in HPA system function during the first weeks of hospitalization predicts response to antidepressant treatment in major depression and thus constitutes a potential biomarker...
  32. ncbi Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels
    R Kumsta
    Department of Theoretical and Clinical Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 32:1153-7. 2007
    ..Investigations of the consequences of long-lasting OC intake on the neuroendocrine stress regulation in women might be warranted...
  33. ncbi Cortisol reactivity is positively related to executive function in preschool children attending head start
    Clancy Blair
    Human Development and Family Studies, The Pennsylvania State University, University Park, 16802, USA
    Child Dev 76:554-67. 2005
    ..Regression analysis indicates that executive function accounted for the association between cortisol reactivity and self-regulation and letter knowledge...
  34. ncbi Impact of stressors in a natural context on release of cortisol in healthy adult humans: a meta-analysis
    Kathy Michaud
    Department of Psychology, Carleton University, Ottawa, Ont, Canada
    Stress 11:177-97. 2008
    ..Nevertheless, there are ample data suggesting that stressful events, through their actions on cortisol levels and reactivity, may influence psychological and physical pathology...
  35. pmc Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling
    Gregory E Miller
    Department of Psychology, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 106:14716-21. 2009
    ..Although these response patterns could serve adaptive functions during acute threats to well-being, over the long term they might exact an allostatic toll on the body that ultimately contributes to the chronic diseases of aging...
  36. ncbi 11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action
    Jonathan R Seckl
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Curr Opin Pharmacol 4:597-602. 2004
    ..Overexpression of this isozyme may contribute to the pathogenesis of the metabolic syndrome. Its inhibition is a potential therapeutic target for both metabolic and glucocorticoid-associated CNS disorders...
  37. pmc Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, Brown Medical School, Providence, Rhode Island 02906, USA
    Biol Psychiatry 62:1080-7. 2007
    ..Abnormal HPA response to stress challenge has been reported in adult patients with major depressive disorder and posttraumatic stress disorder...
  38. ncbi Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications
    Rachel Yehuda
    Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:137-66. 2006
    ..This article summarizes important neuroendocrine observations in cortisol and provides strategies for understanding what has emerged over the past two decades, to be a complex and sometimes contradictory literature...
  39. pmc Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier
    Carola Förster
    Institute of Anatomy and Cell Biology, University of Wurzburg, Koellikerstrasse 6, D 97070 Wurzburg, Germany
    J Physiol 586:1937-49. 2008
    ..Our analyses further provide direct evidence that the GC hydrocortisone prevents endothelial barrier breakdown in response to pro-inflammatory stimuli (TNFalpha administration), ..
  40. ncbi The efficacy of initial hydrocortisone administration at preventing posttraumatic distress in adult trauma patients: a randomized trial
    Douglas L Delahanty
    Department of Psychology, Kent State University, Kent, OH, USA
    CNS Spectr 18:103-11. 2013
    ..The present study examined the preliminary efficacy of a 10-day low-dose (20 mg bid) course of hydrocortisone at preventing PTSS in traumatic injury victims.
  41. ncbi Stirring up new ideas about the regulation of the hypothalamic-pituitary-interrenal axis in zebrafish (Danio rerio)
    Meghan L M Fuzzen
    Department of Integrative Biology, University of Guelph, Guelph, Canada
    Zebrafish 7:349-58. 2010
    ..These findings suggest that multiple genes at all levels of the HPI axis play an active role in the stimulation and termination of the cortisol stress response in zebrafish...
  42. ncbi Sustained elevation of serum interleukin-6 and relative insensitivity to hydrocortisone differentiates posttraumatic stress disorder with and without depression
    Jessica Gill
    National Institutes of Nursing Research, Bethesda, Maryland, USA
    Biol Psychiatry 68:999-1006. 2010
    ..However, IL-6 levels are not consistently elevated in either PTSD or MDD. Although PTSD is associated with supersensitivity to glucocorticoids; prior studies have not evaluated the effect of comorbid MDD...
  43. ncbi Salivary stress markers, stress, and periodontitis: a pilot study
    Balwant Rai
    Oral Imaging Center, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University Leuven, Leuven, Belgium
    J Periodontol 82:287-92. 2011
    ..The present study is planned to explore the associations among periodontal disease, psychologic factors, and salivary markers of stress, psychoneuroimmunologic variables, and health behaviors...
  44. pmc Enhanced human memory consolidation with post-learning stress: interaction with the degree of arousal at encoding
    Larry Cahill
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
    Learn Mem 10:270-4. 2003
    ..These findings further support the view that post-learning stress hormone-related activity interacts with arousal at initial encoding to modulate memory consolidation...
  45. pmc A nonlinear relationship of generalized and central obesity with diurnal cortisol secretion in the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, 2 16 Torrington Place, London, WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 95:4415-23. 2010
    ..Evidence for an association of measures of generalized and central obesity with salivary cortisol secretion is equivocal...
  46. pmc Self-reported sleep duration and sleep disturbance are independently associated with cortisol secretion in the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, United Kingdom
    J Clin Endocrinol Metab 94:4801-9. 2009
    ..The association of short sleep duration with cortisol secretion has not been thoroughly examined in large community dwelling populations and the relative importance of short sleep duration and sleep disturbance is unclear...
  47. ncbi Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior
    E Epel
    UCSF Health Psychology Program, 3333 California St, Suite 465, San Francisco, CA 94118, USA
    Psychoneuroendocrinology 26:37-49. 2001
    ..These results suggest that psychophysiological response to stress may influence subsequent eating behavior. Over time, these alterations could impact both weight and health...
  48. ncbi Acute HPA axis responses, heart rate, and mood changes to psychosocial stress (TSST) in humans at different times of day
    Brigitte M Kudielka
    Department of Behavioral Sciences, Swiss Federal Institute of Technology ETH, Turnerstr 1, CH 8092 Zurich, Switzerland
    Psychoneuroendocrinology 29:983-92. 2004
    ..We conclude that comparable HPA axis and heart rate stress responses to psychosocial stress can be measured in the morning and afternoon...
  49. ncbi Murine brain capillary endothelial cells exhibit improved barrier properties under the influence of hydrocortisone
    Christian Weidenfeller
    Institute for Biochemistry, University of Muenster, Wilhelm Klemm Str 2, 48149 Muenster, Germany
    Brain Res 1053:162-74. 2005
    b>Hydrocortisone is known to induce barrier properties in porcine primary cultures of microvascular endothelial cells...
  50. pmc Exposure to recurrent sleep restriction in the setting of high caloric intake and physical inactivity results in increased insulin resistance and reduced glucose tolerance
    Arlet V Nedeltcheva
    Department of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 94:3242-50. 2009
    ..Epidemiological data indicate that reduced sleep duration is associated with increased incidence of type-2 diabetes...
  51. ncbi Investigation into the cross-correlation of salivary cortisol and alpha-amylase responses to psychological stress
    Veronika Engert
    Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
    Psychoneuroendocrinology 36:1294-302. 2011
    ..As a possible connection site between HPA axis and SNS that may underlie sAA-cortisol associations, we discuss CRF neurons of the hypothalamus involved in sympathetic regulation...
  52. ncbi Neonatal hydrocortisone treatment: neurodevelopmental outcome and MRI at school age in preterm-born children
    Karin J Rademaker
    Department of Neonatology, University Medical Center Utrecht Wilhelmina Children s Hospital, Utrecht, The Netherlands
    J Pediatr 150:351-7. 2007
    To investigate neurodevelopment at school age in preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) in the neonatal period.
  53. ncbi Cognitive appraisals and emotions predict cortisol and immune responses: a meta-analysis of acute laboratory social stressors and emotion inductions
    Thomas F Denson
    School of Psychology, University of New South Wales, Sydney, Australia
    Psychol Bull 135:823-53. 2009
    ..This might be especially relevant for stressors that are acute or imminent, threaten one's social status, or require extended effort...
  54. pmc Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol
    R O'HARA
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305 5550, USA
    Mol Psychiatry 12:544-55. 2007
    ....
  55. pmc Altered basal cortisol levels at 3, 6, 8 and 18 months in infants born at extremely low gestational age
    Ruth E Grunau
    Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    J Pediatr 150:151-6. 2007
    ..Little is known about the developmental trajectory of cortisol levels in preterm infants after hospital discharge...
  56. ncbi Ontogeny of the corticotropin-releasing factor system in zebrafish
    Sarah L Alderman
    University of Guelph, Department of Integrative Biology, Ont, Canada
    Gen Comp Endocrinol 164:61-9. 2009
    ..Overall, results from this study establish the zebrafish as a model species for research on stress during ontogeny and offer new insights into an HPI-axis independent function for the CRF system during embryogenesis...
  57. ncbi Th2 cytokine response in Major Depressive Disorder patients before treatment
    Lenin Pavon
    Department of Psychoimmunology, National Institute of Psychiatry Ramon de la Fuente, Mexico
    J Neuroimmunol 172:156-65. 2006
    ..Further studies are necessary to explore these findings and its implication in future therapeutic approach of MDD patients...
  58. ncbi Psychosocial factors at home and at work and levels of salivary cortisol
    Nanna Hurwitz Eller
    Clinic of Occupational Medicine, Hilleroed Hospital, Helsevej 2 4, DK 3400 Hilleroed, Denmark
    Biol Psychol 73:280-7. 2006
    ..Salivary cortisol as a physiological measure of stress has attracted great interest in recent years...
  59. ncbi Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder
    Nicolas Rohleder
    Department of Psychology, Institute of Experimental Psychology II, University of Dusseldorf, Dusseldorf, Germany
    Biol Psychiatry 55:745-51. 2004
    ..Alterations include various responses to HPA axis stimulation, different basal hormone levels, and changes in glucocorticoid receptor (GR) numbers on lymphocytes. The functional significance of these latter changes remains elusive...
  60. ncbi Major depression in late life is associated with both hypo- and hypercortisolemia
    Marijke A Bremmer
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 62:479-86. 2007
    ..We also examined whether this might represent different depression subtypes...
  61. ncbi Salivary cortisol in response to acute social rejection and acceptance by peers
    Ginette C Blackhart
    Department of Psychology, East Tennessee State University, PO Box 70649, Johnson City, TN 37614, United States
    Biol Psychol 75:267-76. 2007
    ..Results indicate that social rejection causes psychological distress, but highly defensive individuals appear to be less susceptible than less defensive individuals to increases in salivary cortisol after acute social rejection...
  62. ncbi Identifying patterns in cortisol secretion in an older population. Findings from the Whitehall II study
    Meena Kumari
    Department of Epidemiology and Public Health, UCL, London, UK
    Psychoneuroendocrinology 35:1091-9. 2010
    ..Raised pattern of secretion, which occurs in 27% of our participants is associated with demographic variables, adverse health behaviours, psychosocial environment and impaired physical functioning...
  63. ncbi Social regulation of the cortisol levels in early human development
    Megan R Gunnar
    Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, USA
    Psychoneuroendocrinology 27:199-220. 2002
    ..Finally, the few studies of cortisol activity under conditions of neglectful and abusive care of young children are considered, noting that these often have yielded evidence of reduced rather than increased cortisol levels...
  64. ncbi Human glucocorticoid feedback inhibition is reduced in older individuals: evening study
    C W Wilkinson
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 86:545-50. 2001
    ..Our studies support the hypothesis that glucocorticoid responses to stress in aging individuals are likely to be prolonged due to blunted and delayed inhibition of ACTH secretion, thus increasing the total exposure to glucocorticoids...
  65. ncbi Physiologic markers of chronic stress in premenopausal, middle-aged women
    Lynda H Powell
    Department of Preventive Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    Psychosom Med 64:502-9. 2002
    ..The purpose of this study was to identify physiological markers of chronic stress in middle-aged women that can be assessed simply and are thus feasible for introduction into large-scale, epidemiologic studies of aging...
  66. ncbi Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge
    Brigitte M Kudielka
    Jacobs Center on Lifelong Learning and Institutional Development, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany
    Psychoneuroendocrinology 34:2-18. 2009
    ....
  67. ncbi Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model
    Minjun Chen
    School of Pharmacy, Shanghai Jiaotong University, Shanghai 200030, China
    J Proteome Res 4:2391-6. 2005
    This work describes the metabonomic study of a biochemical modification in vivo induced by high dose of hydrocortisone, which led to a unique pathologic condition similar to the 'kidney deficiency syndromes', an early stage of obesity and ..
  68. ncbi Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer: results of the cancer and leukemia group B 9182 study
    P W Kantoff
    Lank Center for Genitourinary Oncology and Breast Oncology Center, Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 6084, USA
    J Clin Oncol 17:2506-13. 1999
    ..The purpose of this study was to demonstrate an advantage of mitoxantrone and hydrocortisone (M+H) over hydrocortisone alone with respect to survival duration.
  69. ncbi HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults, and children: impact of age and gender
    B M Kudielka
    Department of Behavioural Sciences, Swiss Federal Institute of Technology ETH, Turnerstr 1, CH 8092, Zurich, Switzerland
    Psychoneuroendocrinology 29:83-98. 2004
    ..It can be speculated if corticosteroid binding globulin (CBG) and/or sex steroids are important modulators of these effects...
  70. ncbi Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features
    R Rossi
    Dipartimento di Endocrinologia, Universita di Napoli Federico II, Italy
    J Clin Endocrinol Metab 85:1440-8. 2000
    ..These findings support the hypothesis that clinically silent hypercortisolism is probably not completely asymptomatic...
  71. ncbi Associations between pituitary-adrenocortical function and abdominal obesity, hyperinsulinaemia and dyslipidaemia in normotensive males
    A Hautanen
    Department of Clinical Chemistry, University of Helsinki, Finland
    J Intern Med 241:451-61. 1997
    ..To examine the relationships between pituitary-adrenal cortical (PA) function, abdominal obesity, hyperinsulinaemia, and dyslipidaemia...
  72. ncbi Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: effects of cosurfactants
    Gamal M El Maghraby
    Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, P O Box 2457, Saudi Arabia
    Int J Pharm 355:285-92. 2008
    This study investigated the effects of cosurfactants on the transdermal delivery of hydrocortisone (model drug) from eucalyptus oil microemulsion. Eucalyptus oil which was successfully employed for steroidal drugs was used as the oil...
  73. ncbi The effect of abrupt weaning of suckler calves on the plasma concentrations of cortisol, catecholamines, leukocytes, acute-phase proteins and in vitro interferon-gamma production
    M C Hickey
    Teagasc, Grange Research Centre, Dunsany, Co Meath, Ireland
    J Anim Sci 81:2847-55. 2003
    ..Abrupt weaning increased plasma cortisol and noradrenaline concentrations that were accompanied by attenuation of in vitro interferon-gamma production to novel mitogen and antigen complexes up to 7 d after weaning...
  74. ncbi Stability of salivary steroids: the influences of storage, food and dental care
    M Groschl
    Hospital for Children and Adolescents, Friedrich Alexander University, Erlangen Nurnberg, Germany
    Steroids 66:737-41. 2001
    ..Only F decreased significantly after the third thawing (P < 0.001). The results show the usefulness of standardized handling of saliva samples for improving reproducibility and reliability of salivary steroid measurements...
  75. ncbi Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress
    Robert Kumsta
    Department of Psychobiology, University of Trier, Trier, Germany
    Biol Psychiatry 62:863-9. 2007
    ..Alterations in glucocorticoid (GC) signaling have been associated with a number of psychiatric disorders. Genetic variation of the glucocorticoid receptor (GR) might be one of the factors underlying susceptibility to stress related disease...
  76. ncbi A new view on hypocortisolism
    Eva Fries
    Department for Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    Psychoneuroendocrinology 30:1010-6. 2005
    ..This assumption will be underlined by some studies suggesting protective effects of hypocortisolism for the individual...
  77. ncbi Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
    J Clin Endocrinol Metab 90:2522-30. 2005
    ..Given the activating role of IL-6 on the hypothalamic-pituitary-adrenal (HPA) axis, and the relevance of its dysregulation in MDD, we also analyzed the relations between IL-6 and cortisol levels...
  78. pmc Childhood parental loss and adult hypothalamic-pituitary-adrenal function
    Audrey R Tyrka
    Mood Disorders Research Program, Laboratory for Clinical Neuroscience, Butler Hospital, Providence, Rhode Island 02906, USA
    Biol Psychiatry 63:1147-54. 2008
    ....
  79. ncbi 11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action
    Nicole Draper
    Division of Medical Sciences, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Endocrinol 186:251-71. 2005
    ..In each case, these clinical studies have been underpinned by studies in vitro and the manipulation of enzyme expression in vivo using recombinant mouse models...
  80. pmc Modified-release hydrocortisone to provide circadian cortisol profiles
    Miguel Debono
    Academic Unit of Diabetes, School of Medicine, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2JF, United Kingdom
    J Clin Endocrinol Metab 94:1548-54. 2009
    ..Loss of this rhythm is associated with metabolic abnormalities, fatigue, and poor quality of life. Conventional glucocorticoid replacement cannot replicate this rhythm...
  81. ncbi How stress gets under the skin: cortisol and stress reactivity in psoriasis
    A W M Evers
    Department of Medical Psychology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 163:986-91. 2010
    ..Psychological stressors might contribute to the severity of chronic inflammatory diseases such as psoriasis by dysregulating hypothalamic-pituitary-adrenal (HPA) axis activity...
  82. ncbi Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 83:757-60. 1998
    ..Moreover, this study provides the first evidence that intrauterine programming of the HPAA may be a mechanism underlying the association between low birth weight and the insulin resistance syndrome in adult life...
  83. ncbi Awakening cortisol responses are influenced by health status and awakening time but not by menstrual cycle phase
    B M Kudielka
    Department of Experimental Psychology II, University of Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Psychoneuroendocrinology 28:35-47. 2003
    ..Moreover, health status and age appear to have an impact on this marker of adrenocortical activity. Wake-up time, health status and age should therefore be controlled for in future studies measuring cortisol responses to awakening...
  84. ncbi Increased cortisol bioavailability, abdominal obesity, and the metabolic syndrome in obese women
    Martine Duclos
    Laboratoire Neurogenetique et Stress, INSERM U471, Institut Francois Magendie, Universite Bordeaux II, rue C Saint Saëns, 33077 Bordeaux Cedex, France
    Obes Res 13:1157-66. 2005
    ..This study was conducted to obtain a detailed profile of hypothalamo-pituitary-adrenal (HPA) axis activity and reactivity and its differential relationships with body fat distribution and total fat mass in premenopausal obese women...
  85. ncbi Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial
    Kristi L Watterberg
    Division of Neonatology, Department of Pediatrics Neonatology, University of New Mexico School of Medicine, MSC10 5590, Albuquerque, NM 87131 0001, USA
    Pediatrics 114:1649-57. 2004
    ..A pilot study of low-dose hydrocortisone therapy for prophylaxis of early adrenal insufficiency showed improved survival without BPD at 36 weeks' ..
  86. pmc Urinary cortisol and six-year risk of all-cause and cardiovascular mortality
    Nicole Vogelzangs
    Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 95:4959-64. 2010
    ..The stress hormone cortisol has been linked with unfavorable cardiovascular risk factors, but longitudinal studies examining whether high levels of cortisol predict cardiovascular mortality are largely absent...
  87. ncbi Genetic factors, perceived chronic stress, and the free cortisol response to awakening
    S Wust
    Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstrasse 10 11, 54290, Trier, Germany
    Psychoneuroendocrinology 25:707-20. 2000
    ..In line with several recent studies, the present findings further support the view that the cortisol awakening responses is consistently enhanced under chronic stress conditions...
  88. ncbi The cortisol awakening response: more than a measure of HPA axis function
    Angela Clow
    Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London, UK
    Neurosci Biobehav Rev 35:97-103. 2010
    ..An association between the CAR and the ending of sleep inertia is discussed...
  89. ncbi Effect of psychological stress on the salivary cortisol and amylase levels in healthy young adults
    Noriyasu Takai
    Department of Physiology, Osaka Dental University, 8 1, Kuzuha hanazono cho, Hirakata, Osaka 573 1121, Japan
    Arch Oral Biol 49:963-8. 2004
    ..We examined the effects of psychological stressor and soother on the salivary cortisol and amylase levels in young adults, and compared the characteristics of these parameters...
  90. ncbi Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children
    Thomas G O'Connor
    Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY 14642, USA
    Biol Psychiatry 58:211-7. 2005
    ..This study examined the long-term association between prenatal anxiety and measures of diurnal cortisol at age 10 years...
  91. ncbi Cortisol regulates Na+ uptake in zebrafish, Danio rerio, larvae via the glucocorticoid receptor
    Yusuke Kumai
    Department of Biology, University of Ottawa, Ottawa, ON, Canada
    Mol Cell Endocrinol 364:113-25. 2012
    ....
  92. ncbi State, not trait, neuroendocrine function predicts costly reactive aggression in men after social exclusion and inclusion
    Shawn N Geniole
    Department of Psychology, Brock University, St Catharines, Ontario, Canada
    Biol Psychol 87:137-45. 2011
    ..4%, F(1,)(55)=3.53, p=0.07), but no significant effects were observed in either group alone. The findings add to evidence that individual differences in state neuroendocrine function map onto variability in human social behaviour...
  93. ncbi Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis
    Marie Louise Meewisse
    Center for Psychological Trauma, Academic Medical Center de Meren, Department of Psychiatry, University of Amsterdam, Meibergdreef 5, Amsterdam, The Netherlands
    Br J Psychiatry 191:387-92. 2007
    ..Post-traumatic stress disorder (PTSD) has inconsistently been associated with lower levels of cortisol...
  94. ncbi Recovery of pituitary function in the late-postoperative phase after pituitary surgery: results of dynamic testing in patients with pituitary disease by insulin tolerance test 3 and 12 months after surgery
    C Berg
    Department of Endocrinology, Division of Laboratory Research, University of Duisburg Essen, Essen, Germany
    Eur J Endocrinol 162:853-9. 2010
    ..However, abnormal axes may not be completely recovered by then. The aim of this study was to evaluate dynamic testing 3 and 12 months after transsphenoidal pituitary surgery...
  95. ncbi A meta-analysis of cortisol response to challenge in human aging: importance of gender
    Christian Otte
    Department of Psychiatry, University of California, San Francisco, CA, USA
    Psychoneuroendocrinology 30:80-91. 2005
    ..Prospective studies should explore whether the higher cortisol response in the elderly is a risk factor for developing neuropsychiatric and medical disorders...
  96. ncbi The other side of the curve: examining the relationship between pre-stressor physiological responses and stress reactivity
    Iris M Balodis
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Psychoneuroendocrinology 35:1363-73. 2010
    ....
  97. ncbi Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study
    Renato Pasquali
    Department of Internal Medicine, Endocrinology Unit, University of Bologna, I 40100 Bologna, Italy
    J Clin Endocrinol Metab 87:166-75. 2002
    ..On the other hand, our data suggest that, at least in women, abdominal fat distribution may partially counteract the progressively greater suppressibility of the HPA axis that would be expected according to increasing BMI...
  98. pmc Stress reduces conception probabilities across the fertile window: evidence in support of relaxation
    Germaine M Buck Louis
    Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA
    Fertil Steril 95:2184-9. 2011
    ..To assess salivary stress biomarkers (cortisol and α-amylase) and female fecundity...
  99. pmc Generation of a reference transcriptome for evaluating rainbow trout responses to various stressors
    Cecilia C Sánchez
    Shepherd University, Institute of Environmental and Physical Sciences, Robert C Byrd Science and Technology Center, Shepherdstown, WV 25443, USA
    BMC Genomics 12:626. 2011
    ....
  100. ncbi Neutrophil function and cortisol:DHEAS ratio in bereaved older adults
    Riyad Khanfer
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham B15 2TT, UK
    Brain Behav Immun 25:1182-6. 2011
    ..The stress of bereavement exaggerates the age-related decline in HPA axis and combines with immune ageing to further suppress immune function, which may help to the explain increased risk of infection in bereaved older adults...
  101. ncbi Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cells
    Daniel G Bernabé
    Oral Oncology Center, School of Dentistry of Aracatuba, Unesp Univ Estadual Paulista, Aracatuba, Sao Paulo, Brazil
    Brain Behav Immun 25:574-83. 2011
    ..Finally, 20 OSCC biopsies were shown to express β1- and β2-ARs. These findings suggest that stress hormones can affect oral cancer cells behavior...

Research Grants62

  1. Pro-inflammatory glucocorticoid effects in the CNS
    Robert M Sapolsky; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Glucocorticoids (GCs, including synthetic corticosteroids such as hydrocortisone or prednisone) are anti-inflammatory, and are widely used to decrease the damaging inflammation that occurs ..
  2. Excess androgen production in overweight pubertal girls--precursor to PCOS
    CHRISTINE MICHELE BURT SOLORZANO; Fiscal Year: 2013
    ..Aim 2 will use low-dose hydrocortisone and leuprolide therapy to test whether short-term suppression of adrenocorticotropin or gonadotropin ..
  3. MECHANISMS OF INSULIN RESISTANCE IN MAN
    Robert A Rizza; Fiscal Year: 2013
    ..increase hepatic cortisol production by using a randomized study design in which subjects will either ingest hydrocortisone or placebo for one week followed by either a hyperinsulinemic euglycemic clamp or saline infusion combined ..
  4. BARRIER FUNCTION OF THE GI TRACT IN HEALTH AND DISEASE
    W Allan Walker; Fiscal Year: 2013
    ..to help explain excessive intestinal inflammation in prematures and test maturational prevention with hydrocortisone and probiotics...
  5. Icariin to Prevent Corticosteroid-Related Memory Changes
    E Sherwood Brown; Fiscal Year: 2013
    ..We have identified several promising agents. We propose to explore whether icariin will block the effects of hydrocortisone (cortisol) on memory in healthy controls. The current proposal has two phases...
  6. Physiological vs. pharmacological effects of glucocorticoids on human monocytes.
    PAUL GUYRE; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Steroids related to the natural adrenal hormone hydrocortisone have been used to effectively treat inflammation and autoimmunity for over a half century, but unexplained ..
  7. Glucocorticoids &adipocyte function in human obesity
    Susan K Fried; Fiscal Year: 2013
    ..Because GC effects depend on nutritional state/insulin, we will compare the effects of hydrocortisone administered in the fasted state or in combination with meals, on global gene expression (Affymatrix gene ..
  8. Biobehavioral Studies of Opioid Seeking Behavior
    Mark K Greenwald; Fiscal Year: 2013
    ..Aim 2. Use an alternative neuropharmacological stressor paradigm (reboxetine/hydrocortisone dose combinations) to determine whether activation of noradrenergic (Not applicable) and glucocorticoid ..
  9. Effects of Stress and Stress Hormones on Cognition in HIV-Infected Women
    LEAH HELANE RUBIN; Fiscal Year: 2013
    ..The second study is a hydrocortisone challenge study among HIV+ women contrasting those with (n=15) and without (n=15) a PTSD diagnosis to ..
  10. Sex Differences in Cognitive Response to a Hydrocortisone Challenge in HIV
    LEAH HELANE RUBIN; Fiscal Year: 2013
    ..Specifically, we propose to investigate sex differences in the impact of hydrocortisone on cognitive function in HIV in a double-blind, placebo-controlled, cross-over study in 82 HIV+ adults (41 men,..
  11. NICHD Cooperative Multicenter Neonatal Research Network
    Kristi L Watterberg; Fiscal Year: 2013
    ..Dr. Watterberg is PI for a planned RCT of hydrocortisone to treat BPD (approved by the NRN advisory board), serves on the Protocol Review Subcommittee which provides ..
  12. Development of a Model to Examine Corticosteroid Effects on the Hippocampus
    E Sherwood Brown; Fiscal Year: 2009
    ..using functional magnetic resonance imaging (fMRI) in a group of 16 healthy controls who will receive hydrocortisone, phenytoin, and both medications together in randomized, double-blind, placebo-controlled pilot study using a ..
  13. AIRWAY PHARMACOLOGY DURING ONTOGENESIS
    James Douglas; Fiscal Year: 1993
    ..Our hypothesis is that these maturational changes are closely related to increased levels of plasma hydrocortisone and altered circulating catecholamines concentrations...
  14. AGING EFFECTS OF ANEUPLOIDY
    W Brown; Fiscal Year: 1980
    ..of 21 and X specific proteins will be measured during in vitro fibroblast aging and following addition of hydrocortisone. X chromosomal proteins which have escaped x-inactivation will be searched for using quantitative 2-D analysis ..
  15. L-TRIIODOTHYRONINE EFFECTS ON CELL REGULATION
    Martin Surks; Fiscal Year: 1992
    ..Since GC cell growth can also be regulated by GC cell conditioned medium, calf serum growth factor, hydrocortisone, EGF and defined medium, we will determine whether these regulators result in biochemical changes that are ..
  16. SPECIALIZED TRANSPORT PROPERTIES OF ALVEOLAR EPITHELIUM
    Barbara Goodman; Fiscal Year: 1992
    ..e., sodium transport inhibitors, beta-adrenergic agonists, cyclic AMP analogs, phosphodiesterase inhibitors, hydrocortisone, etc.)...
  17. TSH SECRETION--ROLE OF GLUCOCORTICOIDS
    Mary Samuels; Fiscal Year: 1999
    ..In these subjects, serum cortisol or TSH levels can be manipulated independently by infusions of hydrocortisone or TRH...
  18. Micromass Quattro API TSQ For LC-MS/MS Quantitation
    Walter Hubbard; Fiscal Year: 2002
    ..low level quantitation of phospholipids and products of phospholipid metabolism, fatty acid acyl conjugates of hydrocortisone and triamcinolone acetonide (TAA), neuropeptides, endogenous levels of hydrocortisone and cortisone in nasal ..
  19. Adrenal Insufficiency after Moderate&Severe Head Injury
    Pejman Cohan; Fiscal Year: 2005
    ..inappropriately low cortisol levels that met criteria of ASAI, will be randomized to 48 hours of placebo or hydrocortisone therapy and changes in hemodynamics, cytokine levels, and neurological outcome will be measured...
  20. Randomized Placebo-Controlled Trial of Hydrocortisone in PTSD Prophylaxis
    Joseph Zohar; Fiscal Year: 2013
    ..project is to determine the efficacy of a single injection of 90-140 mg (proportioned to body weight) of hydrocortisone (Hcort) to prevent the subsequent development of posttraumatic stress disorder (PTSD) by engaging biological ..
  21. Cortisol Stress Response & Intake in Obese Binge Eaters
    Allan Geliebter; Fiscal Year: 2006
    ..Specifically, on separate days, we will administer hydrocortisone compared to a placebo and measure cortisol levels and intake from a multiple-item meal following a real life ..
  22. EFFECTS OF INSULIN ON THE CATABOLIC RESPONSE TO TRAUMA
    Palmer Bessey; Fiscal Year: 1991
    ..of the concentrations of the catabolic hormones would be achieved by the infusion of a combined mixture of hydrocortisone, glucagon, and epinephrine...
  23. EPITHELIAL RENEWAL IN PEPTIC AND NEOPLASTIC DISORDERS
    GREGORY EASTWOOD; Fiscal Year: 1980
    ..aspirin ingestion over four weeks stimulates epithelial proliferation in the stomach, whereas ingestion of hydrocortisone sodium succinate for four weeks depresses gastric epithelial proliferation...
  24. EOSINOPHIL INFLUX INTO THE LUNG IN NOCTURNAL ASTHMA
    Monica Kraft; Fiscal Year: 2000
    ..endogenous corticosteroids at night on T lymphocyte function and eosinophil influx, physiologic doses of hydrocortisone to block the nocturnal nadir of cortisol will be infused...
  25. EVAUATION OF CHEMOPREVENTIVE AGENTS BY IN VITRO SCREENIN
    Rajendra Mehta; Fiscal Year: 2000
    ..are excised and incubated in Waymouth's MB752 medium with 5 g insulin, 5 g prolactin, 1 g aldosterone and 1 g hydrocortisone per ml medium for 10 days with a 24 hour exposure of the glands to DMBA (2 g/ml) on day 3...
  26. Hydrocortisone replacement therapy in septic neonatal foals
    KELSEY HART; Fiscal Year: 2009
    ..of death can be significantly reduced if these patients are supplemented with the synthetic cortisol product, hydrocortisone. Preliminary work in our laboratory suggests that HPA axis dysfunction is as prevalent and has the same ..
  27. IN VITRO SCREENING OF CHEMOPREVENTIVE AGENTS IN DMBA-IND
    Rajendra Mehta; Fiscal Year: 1999
    ..are excised and incubated in Waymouth's MB752 medium with 5 g insulin, 5 g prolactin, 1 g aldosterone and 1 g hydrocortisone per ml medium for 10 days with a 24 hour exposure of the glands to DMBA (2 g/ml) on day 3...
  28. In Vitro Screening of Chemopreventive Agents in DMBA
    Rajendra Mehta; Fiscal Year: 1999
    ..in Waymouth's MB752 medium with 5 microg insulin, 5 microg prolactin, 1 microg aldosterone and 1 microg hydrocortisone per ml medium for 10 days with a 24 hour exposure of the glands to DMBA (2 microg/ml) on day 3...
  29. CEREBRAL 18FDG UPTAKE FOLLOWING HYDROCORTISONE IN PTSD
    Robert Grossman; Fiscal Year: 2003
    ..aims are to measure and correlates: 1) central glucocorticoid sensitivity utilizing a placebo-controlled hydrocortisone challenge followed by 18-FDG uptake and PET scanning; 2) peripheral HPA axis measures of cortisol negative ..
  30. CORTISOL EFFECTS ON HUMAN METHAMPHETAMINE RESPONSE
    Debra Harris; Fiscal Year: 2001
    ..Subjective, physiological, and endocrine responses to augmenting cortisol level with hydrocortisone and to lowering cortisol level with the corticosteroid synthesis inhibitor metyrapone will be studied...
  31. Neurological Diseases Research in High Risk Newborns
    Nehal Parikh; Fiscal Year: 2009
    ..infants (who are conventionally treated with high-dose dexamethasone) to assess whether low-dose hydrocortisone therapy prevents the reduced regional and total cortical volumes common among such infants...
  32. POSTNATAL HEMATOGENOUS & INTRATHYMIC T CELL PROGENITORS
    Cornelius Rosse; Fiscal Year: 1993
    ..the contribution of these two progenitor pools to the recovery of the thymus following its depletion by hydrocortisone- or tumor- induced atrophy, and by selective irradiation under conditions which do not deplete the animal's ..
  33. MICROVASCULAR MECHANISMS OF ARTICULAR DAMAGE IN ANTIGEN
    Maren Mahowald; Fiscal Year: 1991
    ..rabbits treated with oral heparin to enhance angiogenesis; and 3) AIA rabbits treated with oral heparin plus hydrocortisone or the non-glucocorticoid, epicortisol to inhibit angiogenesis...
  34. HORMONAL REGULATION OF MICROVASCULAR ENDOTHELIAL CELLS
    William Nichols; Fiscal Year: 1990
    ..assess the effects of inflammatory mediators on MVEC production of PAF and the ability of insulin, IGF-I, and hydrocortisone to modulate PAF production...
  35. IN VITRO SCREENING OF CHEMOPREVENTIVE AGENTS
    Rajendra Mehta; Fiscal Year: 1999
    ..MB752 medium with 5 microgram insulin, 5 microgram prolactin, 1/microgram aldosterone and 1 microgram hydrocortisone per ml medium for 10 days with a 24 hour exposure of the glands to DMBA (2 microgram/ml) on day 3...
  36. MECHANISMS INVOLVED IN TUMOR NEOVASCULARIZATION
    Peter Polverini; Fiscal Year: 1980
    ..response to tumors in hamsters depleted of monocytes and macrophages by treatment with antimacrophage serum hydrocortisone acetate, and 4) an examination of the angiogenic potential of these and other tumor derived leukocytes ..
  37. DEVELOPMENT OF TRANSPORT SYSTEMS IN EMBRYONIC INTESTINE
    Betty Black; Fiscal Year: 1990
    ..14 and 19 day old embryos will be cultured for 2-4 days in the presence of individual hormones (thyroxine, hydrocortisone, insulin, and vitamin D) to determine whether active glucose transport can be induced in young intestine and ..
  38. CARCINOGEN SUPPRESSION OF KERATINOCYTE DIFFERENTIATION
    Robert Rice; Fiscal Year: 1990
    ..To test the hypothesis that this suppression is mediated by vitamin A as a consequence of TCDD antagonism of hydrocortisone action, the effect of TCDD on expression of transglutaminase and kertains will be measured in the absence of ..
  39. A Convergent Total Synthesis of (+)-Wortmannin
    Ryan Van de Water; Fiscal Year: 2005
    ..known for almost fifty years, has only succumbed to one racemic total synthesis and one partial synthesis from hydrocortisone. In addition to its antibiotic properties, wortmannin was found to be a potent phosphatidylinositol 3-kinase (..
  40. Prophylaxis of adrenal insufficiency to prevent CLD
    Kristi Watterberg; Fiscal Year: 2005
    ..This study showed that hydrocortisone prophylaxis against adrenal insufficiency during the first two weeks of life resulted in a significant ..
  41. BEHAVIORAL MEDICINE: CARDIOVASCULAR DISEASE RESEARCH
    William Lovallo; Fiscal Year: 2003
    ..U. medical campus. Training will utilize classroom, laboratory, and clinical facilities at several departments and hospitals on campus. ..
  42. Early experience and low 5-HT markers in alcohol abuse
    Mark Laudenslager; Fiscal Year: 2009
    ..Finally, involvement of the HPA axis in these relationships will be investigated as an exploratory goal. ..
  43. BEHAVIORAL AND PHYSIOLOGICAL CONSEQUENCES OF LOSS
    Mark Laudenslager; Fiscal Year: 2003
    ..The present application seeks to identify developmental factors affecting the HPA axis and the balance of CORT and DHEA with consequences for individual differences in rates of progression in immunodeficiency disease. ..
  44. CAFFEINE INFLUENCES ON EXERCISE AND PSYCHOLOGICAL STRESS
    William Lovallo; Fiscal Year: 2004
    ..This new information should aid in evaluating caffeine's effects over the span of midlife, a time at which the cardiovascular health of women changes markedly relative to men. ..
  45. PREVENTIVE INTERVENTION FOR MALTREATED INFANTS
    Dante Cicchetti; Fiscal Year: 2002
    ....
  46. Prenatal Glucocorticoids Influence Brain and Behavior
    Elysia Poggi Davis; Fiscal Year: 2010
    ..This project will provide the first opportunity to examine the independent influence of fetal exposure to GC's in a group of children born at term. ..
  47. PREVENTIVE INTERVENTION--TODDLERS OF DEPRESSED MOTHERS
    Dante Cicchetti; Fiscal Year: 2003
    ..This investigation also will increase understanding of the developmental contributors to psychopathological outcomes in offspring of depressed mothers. ..
  48. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ....
  49. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  50. Brain Function in Pediatric PTSD
    Victor Carrion; Fiscal Year: 2005
    ....
  51. Massaging Preterm Infants Enhances Growth
    Tiffany Field; Fiscal Year: 2006
    ..abstract_text> ..
  52. Aromatase Inhibitor in Males with Adrenal Hyperplasia
    Kyriakie Sarafoglou; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  53. Neurohormonal Effects of Massage Therapy
    Tiffany Field; Fiscal Year: 2007
    ..The K05 would allow me to increase my research time including being mentored and mentoring students from 25 to 75% time. [unreadable] [unreadable] [unreadable]..
  54. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  55. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  56. The Role of Corticotropin-Releasing Factor in Primate Maternal Behavior
    Wendy Saltzman; Fiscal Year: 2007
    ..Ultimately, this research will have implications for the understanding and treatment of stress-related psychopathology in women. [unreadable] [unreadable] [unreadable]..
  57. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  58. Prenatal Programming of Infant Temperament
    Elysia Davis; Fiscal Year: 2008
    ..Prospective studies, such as this one, are needed to better understand processes that might underlie this association. [unreadable] [unreadable] [unreadable]..
  59. ALCOHOLISM AND ENDOGENOUS OPIOID ACTIVITY
    Gary Wand; Fiscal Year: 2008
    ..Fortype specifications, see instructions onpage 6.) RESEARCH GRANT TABLE OF CONTENTS PageNumbers Face Page 1 Description, ..
  60. TEEN DRUG USE/ABUSE: PATHWAYS FROM CHILD MALTREATMENT
    Dante Cicchetti; Fiscal Year: 2004
    ..Psychopathology and problem adolescent behaviors also will be assessed. ..