corticosterone

Summary

Summary: An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

Top Publications

  1. pmc Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    Denis J David
    Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
    Neuron 62:479-93. 2009
  2. ncbi Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    F Tronche
    Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Genet 23:99-103. 1999
  3. ncbi A transgenic model of visceral obesity and the metabolic syndrome
    H Masuzaki
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
    Science 294:2166-70. 2001
  4. ncbi The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
    C Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 49:1023-39. 2001
  5. ncbi Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions
    Stephanie Ridder
    Division of Molecular Biology of the Cell I, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Neurosci 25:6243-50. 2005
  6. pmc Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone
    Henk Karst
    Swammerdam Institute for Life Sciences, Center for Neurosciences SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:19204-7. 2005
  7. ncbi Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
    G W Smith
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Neuron 20:1093-102. 1998
  8. ncbi Periodic maternal separation decreases hippocampal neurogenesis without affecting basal corticosterone during the stress hyporesponsive period, but alters HPA axis and coping behavior in adulthood
    Naima Lajud
    Division de Neurociencias, Centro de Investigación Biomédica de Michoacán Instituto Mexicano del Seguro Social, Morelia 58341, Michoacan, Mexico
    Psychoneuroendocrinology 37:410-20. 2012
  9. ncbi Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors
    A M Magarinos
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Neuroscience 69:89-98. 1995
  10. ncbi Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration
    Quentin Rainer
    Equipe d Accueil 3544, Laboratoire de Neuropharmacologie, Universite Paris XI, Chatenay Malabry, France
    Mol Pharmacol 81:106-12. 2012

Detail Information

Publications387 found, 100 shown here

  1. pmc Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    Denis J David
    Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
    Neuron 62:479-93. 2009
    ..Here we describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment...
  2. ncbi Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    F Tronche
    Molecular Biology of the Cell I, Deutsches Krebsforschungzentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Genet 23:99-103. 1999
    ..Conditional mutagenesis of Gr in the nervous system provides genetic evidence for the importance of Gr signalling in emotional behaviour because mutant animals show an impaired behavioural response to stress and display reduced anxiety...
  3. ncbi A transgenic model of visceral obesity and the metabolic syndrome
    H Masuzaki
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
    Science 294:2166-70. 2001
    ..These mice had increased adipose levels of corticosterone and developed visceral obesity that was exaggerated by a high-fat diet...
  4. ncbi The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
    C Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 49:1023-39. 2001
    ..The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults...
  5. ncbi Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions
    Stephanie Ridder
    Division of Molecular Biology of the Cell I, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Neurosci 25:6243-50. 2005
    ..As a first potential molecular correlate for such changes, we identified a downregulation of BDNF protein content in the hippocampus of GR+/- mice, which is in agreement with the so-called neurotrophin hypothesis of depression...
  6. pmc Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone
    Henk Karst
    Swammerdam Institute for Life Sciences, Center for Neurosciences SILS CNS, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:19204-7. 2005
    The adrenal hormone corticosterone transcriptionally regulates responsive genes in the rodent hippocampus through nuclear mineralocorticoid and glucocorticoid receptors...
  7. ncbi Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
    G W Smith
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Neuron 20:1093-102. 1998
    ..Homozygous mutant mice derived from crossing heterozygotes displayed low plasma corticosterone concentrations resulting from a marked agenesis of the zona fasciculata region of the adrenal gland...
  8. ncbi Periodic maternal separation decreases hippocampal neurogenesis without affecting basal corticosterone during the stress hyporesponsive period, but alters HPA axis and coping behavior in adulthood
    Naima Lajud
    Division de Neurociencias, Centro de Investigación Biomédica de Michoacán Instituto Mexicano del Seguro Social, Morelia 58341, Michoacan, Mexico
    Psychoneuroendocrinology 37:410-20. 2012
    ..MS180 and AFR pups showed similar corticosterone (CORT) basal levels between PND 3 and 12, whereas adult MS180 rats presented with higher CORT levels than AFR ..
  9. ncbi Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors
    A M Magarinos
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Neuroscience 69:89-98. 1995
    ..This effect is mimicked by daily corticosterone treatment for 21 days and is prevented y the anti-epileptic drug, phenytoin, known to interfere with ..
  10. ncbi Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration
    Quentin Rainer
    Equipe d Accueil 3544, Laboratoire de Neuropharmacologie, Universite Paris XI, Chatenay Malabry, France
    Mol Pharmacol 81:106-12. 2012
    ..We have developed a mouse model of anxiety/depression based on addition of corticosterone to drinking water...
  11. ncbi Endotoxin-induced hypoxic-ischemic tolerance is mediated by up-regulation of corticosterone in neonatal rat
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Kihara, Japan
    Pediatr Res 59:56-60. 2006
    ..LPS (1.0 mg/kg) injected into 6-d-old rats transiently up-regulated serum corticosterone levels (119.6, 57.9, 56.8, and 28.3 ng/mL at 6, 12, 24, and 48 h after the LPS injection, respectively)...
  12. ncbi Chronic social instability stress in female rats: a potential animal model for female depression
    C J Herzog
    Clinical Neurobiology Laboratory, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Gottingen, Germany
    Neuroscience 159:982-92. 2009
    ..At the physiological level, increased adrenal weight and plasma corticosterone levels indicated hyperactivity of the hypothalamus-pituitary-adrenal axis...
  13. pmc Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University School of Medicine, Campus de Espinardo, 30100 Murcia, Spain
    Endocrinology 150:3118-27. 2009
    ..This study addressed the role of morphine withdrawal-induced corticosterone (CORT) release in regulation of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine ..
  14. ncbi Early life experience alters response of adult neurogenesis to stress
    Christian Mirescu
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Neurosci 7:841-6. 2004
    ..Although maternally separated rats show normal basal levels of corticosterone, the suppression of cell proliferation in these rats can be reversed by lowering corticosterone below the ..
  15. ncbi Differential impact of juvenile stress and corticosterone in juvenility and in adulthood, in male and female rats
    Shlomit Jacobson-Pick
    Department of Neurobiology, University of Haifa, Mount Carmel, 31905 Haifa, Israel
    Behav Brain Res 214:268-76. 2010
    ..Furthermore, both male and female rats were examined, and in addition, the role of corticosterone as a potential mediator of some of these effects in juvenility and in adulthood, was assessed...
  16. ncbi Interannual variability of Black-legged Kittiwake productivity is reflected in baseline plasma corticosterone
    C Loren Buck
    Department of Biological Sciences, University of Alaska Anchorage, ENG 333, 3211 Providence Drive, Anchorage, AK 99508, USA
    Gen Comp Endocrinol 150:430-6. 2007
    ..examined the link between seabird productivity and an indirect measure of food availability: baseline plasma corticosterone. We predicted low productivity would coincide with elevated baseline corticosterone levels in Black-legged ..
  17. ncbi Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice
    Alessandra Berry
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Psychoneuroendocrinology 37:762-72. 2012
    ..Aim of this paper was to study the relationship between neuroendocrine activation (circulating corticosterone and brain BDNF levels) and a wide array of depression- and anxiety-like behaviours (anhedonia, behavioural ..
  18. ncbi The postnatal development of the hypothalamic-pituitary-adrenal axis in the mouse
    Mathias V Schmidt
    Gorlaeus Laboratories, Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Centre, Leiden University, P O Box 9502, The Netherlands
    Int J Dev Neurosci 21:125-32. 2003
    ..Lasting from postnatal day (pnd) 4 to pnd 14, this period is characterized by very low basal corticosterone levels and an inability of mild stressors to induce an enhanced ACTH and corticosterone release...
  19. ncbi Adipogenic and lipolytic effects of chronic glucocorticoid exposure
    Jonathan E Campbell
    York University, Toronto, Ontario, Canada
    Am J Physiol Cell Physiol 300:C198-209. 2011
    ..Here we investigate both the in vitro and in vivo effects of corticosterone (Cort) on adipose tissue metabolism...
  20. ncbi Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model
    Frances A Champagne
    McGill Program for the Study of Behavior, Genes and Environment and Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    Biol Psychiatry 59:1227-35. 2006
    ..We addressed the question of whether stressors can directly affect parental behavior using a rodent model of stable, individual differences in maternal behavior...
  21. ncbi Adrenalectomy stimulates the formation of initial atherosclerotic lesions: reversal by adrenal transplantation
    Ronald J van der Sluis
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, P O Box 9502, 2300RA Leiden, The Netherlands
    Atherosclerosis 221:76-83. 2012
    ..Atherogenic diet feeding raised plasma corticosterone levels in SHAM mice, but not adrenalectomized mice, resulting in an 83% lower (P<0...
  22. ncbi Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone
    Wasana Pratchayasakul
    Cardiac Electrophysiology Research and Training Center, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    Life Sci 88:619-27. 2011
    Chronic consumption of a high-fat (HF) diet contributes to peripheral insulin resistance and elevated plasma corticosterone. However, the effect of HF consumption on the neurofunctional insulin receptors and neuronal corticosterone level ..
  23. ncbi Congenital absence of vasopressin and age-dependent changes in ACTH and corticosterone stress responses in rats
    D Zelena
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Stress 14:420-30. 2011
    ..normal pituitary and adrenocortical secretory responses, while in all 10-day-old rats stress-induced serum corticosterone increases were marked, but adrenocorticotropin (ACTH) increases were significantly smaller...
  24. ncbi Ginkgo biloba normalizes stress- and corticosterone-induced impairment of recall in rats
    Anna Walesiuk
    Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15 274 Bialystok, Poland
    Pharmacol Res 53:123-8. 2006
    ..The results showed that chronic restraint stress (2h for 21 days) or an 'equivalent' dose of exogenous corticosterone (5 mg kg(-1)) decreased re-entry latencies in the passive avoidance situation showing thus impairment of ..
  25. ncbi Disrupted corticosterone pulsatile patterns attenuate responsiveness to glucocorticoid signaling in rat brain
    R Angela Sarabdjitsingh
    Division of Medical Pharmacology, Leiden Amsterdam Centre for Drug Research Leiden University Medical Centre, University of Leiden, Einsteinweg 55, P O Box 9502, 2300 RA Leiden, The Netherlands
    Endocrinology 151:1177-86. 2010
    ..Here we hypothesized that such sustained glucocorticoid levels, disturbing corticosterone pulsatility, attenuate glucocorticoid receptor signaling and target gene responsiveness to an acute challenge ..
  26. ncbi Prenatal stress and neonatal rat brain development
    D L A Van den Hove
    Department of Pediatrics, Research Institute Growth and Development, Faculty of Medicine, Maastricht University, P Debyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Neuroscience 137:145-55. 2006
    ..We studied the effects of prenatal stress on fetal growth, stress-induced corticosterone secretion, brain cell proliferation, caspase-3-like activity and brain-derived neurotrophic factor protein ..
  27. ncbi Effects of stress and corticosterone on activity and plasticity in the amygdala
    Alexandra Kavushansky
    Department of Psychology and Brain and Behavior Research Center, University of Haifa, Haifa, Israel
    J Neurosci Res 84:1580-7. 2006
    ..We studied the effects of stress and corticosterone (CORT) on activity and plasticity in the BLA in the rat, using the electrophysiological procedure of long-term ..
  28. pmc Hypothalamic-pituitary-adrenal axis abnormalities in response to deletion of 11beta-HSD1 is strain-dependent
    R N Carter
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    J Neuroendocrinol 21:879-87. 2009
    ..On this background, concentrations of plasma corticosterone and adrenocorticotrophic hormone (ACTH) were elevated in unstressed mice, and showed a delayed return to ..
  29. ncbi Neonatal lipopolysaccharide and adult stress exposure predisposes rats to anxiety-like behaviour and blunted corticosterone responses: implications for the double-hit hypothesis
    Adam K Walker
    Laboratory of Neuroimmunology, School of Psychology, The University of Newcastle, Callaghan, NSW, Australia
    Psychoneuroendocrinology 34:1515-25. 2009
    ..Prior to and following behavioural test sessions, peripheral blood was collected to assess serum corticosterone and ACTH levels...
  30. ncbi Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress
    Susanne K Droste
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Clinical Science South Bristol, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, United Kingdom
    Endocrinology 149:3244-53. 2008
    Circulating corticosterone levels show an ultradian rhythm resulting from the pulsatile release of glucocorticoid hormone by the adrenal cortex...
  31. pmc Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory
    Patrizia Campolongo
    Department of Physiology and Pharmacology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Proc Natl Acad Sci U S A 106:4888-93. 2009
    ..14 ng per 0.2 microL per side) blocked the memory-enhancing effect induced by systemic administration of corticosterone (3 mg/kg, s.c.)...
  32. ncbi Modulation of motor function by stress: a novel concept of the effects of stress and corticosterone on behavior
    Gerlinde A Metz
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Eur J Neurosci 22:1190-200. 2005
    ..Here we demonstrate that stress and the stress hormone corticosterone influence motor system function in rats...
  33. ncbi Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi 755 8505, Japan
    J Neurosci 30:15007-18. 2010
    ..These results suggest that the activation of REST4-mediated gene regulation in the mPFC during postnatal development is involved in stress vulnerability...
  34. ncbi Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin
    Alexa H Veenema
    Department of Behavioural Neuroendocrinology, Institute of Zoology, University of Regensburg, Regensburg, Germany
    Eur J Neurosci 24:1711-20. 2006
    ..Furthermore, the maternal separation-induced changes in hypothalamic AVP and 5-HT systems may underlie these behavioural alterations...
  35. ncbi Analyzing corticosterone metabolites in fecal samples of mice: a noninvasive technique to monitor stress hormones
    Chadi Touma
    Department of Behavioural Biology, University of Muenster, D 48149 Muenster, Germany
    Horm Behav 45:10-22. 2004
    ..pharmacological stimulation and suppression of adrenocortical activity was reflected accurately by means of corticosterone metabolite (CM) measurements in the feces of males and females...
  36. pmc Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice
    Janice M Paterson
    Wellcome Trust CVRI Molecular Physiology Group, University of Edinburgh Medical School, Wilkie Building, Teviot Place, Edinburgh EH8 9AG, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 101:7088-93. 2004
    ....
  37. ncbi Interaction between corticosterone and insulin in obesity: regulation of lard intake and fat stores
    Susanne E la Fleur
    Department of Physiology, University of California, San Francisco, 513 Parnassus Avenue, Box 0444, San Francisco, California 94143 0444, USA
    Endocrinology 145:2174-85. 2004
    ..We performed three experiments to determine the relationship of corticosterone and insulin to lard intake, chow intake, body weight, hormones, and fat depots...
  38. ncbi Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism
    Shi Di
    Division of Neurobiology, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118 5698, USA
    J Neurosci 23:4850-7. 2003
    ..neurons of the hypothalamic paraventricular nucleus (PVN) by the glucocorticoids dexamethasone and corticosterone. The effect was maintained with dexamethasone conjugated to bovine serum albumin and was not seen with direct ..
  39. pmc Acute corticosterone treatment is sufficient to induce anxiety and amygdaloid dendritic hypertrophy
    Rupshi Mitra
    Department of Biology, Stanford University, Gilbert Building, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:5573-8. 2008
    ..treated either acutely with a single dose or chronically with 10 daily doses of high physiological levels of corticosterone (the rat-specific glucocorticoid)...
  40. pmc Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice
    Richard S Lee
    Department of Psychiatry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
    Endocrinology 151:4332-43. 2010
    ..hypothesis that expression changes would be induced in Fkbp5 and other HPA axis genes by chronic exposure to corticosterone and that these changes would occur through the epigenetic mechanism of loss or gain of DNA methylation (DNAm)...
  41. pmc Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse
    Ilia N Karatsoreos
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    Endocrinology 151:2117-27. 2010
    ..How different mediators of the stress response, such as corticosterone (CORT), influence these changes in risk remains unclear...
  42. pmc Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation
    Mélanie G Gareau
    Intestinal Disease Research Program, Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gut 56:1522-8. 2007
    ..We previously showed that neonatal maternal separation (MS) of rat pups causes immediate and long-term changes in intestinal physiology...
  43. pmc Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
    Proc Natl Acad Sci U S A 103:6741-6. 2006
    ..b>Corticosterone administered immediately after object recognition training enhanced 24-h memory of naïve male rats but not ..
  44. pmc Stress at learning facilitates memory formation by regulating AMPA receptor trafficking through a glucocorticoid action
    Lisa Conboy
    Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Neuropsychopharmacology 35:674-85. 2010
    ..In cell cultures, corticosterone has been shown to condition the synaptic trafficking of the AMPAR GluA2 subunit...
  45. ncbi Differential effects of acute and chronic social defeat stress on hypothalamic-pituitary-adrenal axis function and hippocampal serotonin release in mice
    A Keeney
    Psychopharmacological Research, H Lundbeck A S, Copenhagen, Denmark
    J Neuroendocrinol 18:330-8. 2006
    ..Repeated social defeat of male NMRI mice has been shown to induce increases in core body temperature and corticosterone, indicative of a state of chronic stress in subordinate animals...
  46. pmc Metaplasticity of amygdalar responses to the stress hormone corticosterone
    Henk Karst
    Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3508 AB, Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 107:14449-54. 2010
    ..long-lasting change in state of amygdala neurons greatly affects the responsiveness to subsequent surges of corticosterone, revealing a quick suppression of glutamatergic transmission, which requires the glucocorticoid receptor...
  47. ncbi Maternal care and selection for low mortality affect post-stress corticosterone and peripheral serotonin in laying hens
    T Bas Rodenburg
    Animal Breeding and Genomics Centre, Wageningen University, P O Box 338, 6700 AH Wageningen, The Netherlands
    Physiol Behav 98:519-23. 2009
    ..present study was to investigate the effect of brooding and group selection for low mortality on post-stress corticosterone and peripheral serotonin in laying hens...
  48. ncbi Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats
    T Buchenauer
    Institute for Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany
    Physiol Behav 98:563-9. 2009
    ..Fitting to a different behavioral response, basal corticosterone levels (measured by RIA) of obese animals were significantly elevated (16.0ng/ml vs. 12.5ng/ml; p<0.01)...
  49. ncbi Effects of chronic social stress in adolescence on anxiety and neuroendocrine response to mild stress in male and female rats
    C M McCormick
    Neuroscience Program, Brock University, St Catharines, ON, Canada L2S 3A1
    Behav Brain Res 187:228-38. 2008
    ..adolescence on anxiety-like behaviour in the elevated plus maze (EPM) and determined the temporal pattern of corticosterone release after confinement to the open arm of the EPM...
  50. pmc Fear of novelty in infant rats predicts adult corticosterone dynamics and an early death
    S A Cavigelli
    Department of Psychology and Institute for Mind and Biology, University of Chicago, 940 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 100:16131-6. 2003
    ....
  51. pmc Stressor-specific alterations in corticosterone and immune responses in mice
    Stephanie L Bowers
    Departments of Psychology, Neuroscience, and Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 22:105-13. 2008
    ..Here we examine the effects of chronic stressors on plasma corticosterone concentrations, leukocyte redistribution, and skin delayed-type hypersensitivity (DTH), and the effects of ..
  52. ncbi The corticosterone synthesis inhibitor metyrapone prevents hypoxia/ischemia-induced loss of synaptic function in the rat hippocampus
    H J Krugers
    Institute for NeurobiologyA Graduate School for Neurosciences, University of Amsterdam, Amsterdam, The Netherlands
    Stroke 31:1162-72. 2000
    Ischemia is accompanied by abundant corticosterone secretion, which could potentially exacerbate brain damage via activation of glucocorticoid receptors...
  53. ncbi Behavioral profiles and stress-induced corticosteroid secretion in male Wistar rats subjected to short and prolonged periods of maternal separation
    Erika Roman
    Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala University, P O Box 591, SE 751 24 Uppsala, Sweden
    Horm Behav 50:736-47. 2006
    ..In response to a restraint stress, MS360 rats had a blunted corticosterone release in contrast to MS15 and AFR rats...
  54. ncbi Non-invasive monitoring of glucocorticoid physiology within highland and lowland populations of native Australian Great Barred Frog (Mixophyes fasciolatus)
    Clara M Graham
    Environmental Futures Centre, School of Environment, Griffith University, Nathan Campus, QLD 4111, Australia
    Gen Comp Endocrinol 191:24-30. 2013
    This study used non-invasive endocrinology to examine baseline corticosterone at different altitudes in a free-living Australian amphibian: the Great Barred Frog (Mixophyes fasciolatus)...
  55. ncbi Corticosterone responses in birds: individual variation and repeatability in Adelie penguins (Pygoscelisadeliae) and other species, and the use of power analysis to determine sample sizes
    John F Cockrem
    Conservation Endocrinology Research Group, Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand
    Gen Comp Endocrinol 163:158-68. 2009
    Plasma corticosterone concentrations increase when birds experience a stressor, and in this study we quantified variation in corticosterone responses for the first time in a species of free-living bird...
  56. ncbi Endotoxin exposure in early life alters the development of anxiety-like behaviour in the Fischer 344 rat
    Frederick Rohan Walker
    Laboratory of Neuroimmunology, School of Behavioural Sciences, University of Newcastle, Newcastle 2308, NSW, Australia
    Behav Brain Res 154:63-9. 2004
    ..Neonatal endotoxin exposure was found to significantly increase circulating levels of corticosterone on postnatal days 3 and 5 at 4 h postadministration (P < 0.05)...
  57. ncbi Repeated exposure to stressors do not accelerate atherosclerosis in ApoE-/- mice
    Evelina Bernberg
    Department of Molecular and Clinical Medicine Clinical Physiology, Sahlgrenska Academy, The University of Gothenburg, Goteborg, Sweden
    Atherosclerosis 204:90-5. 2009
    ..Urine and plasma were collected for corticosterone and lipid analysis, respectively...
  58. pmc Glucocorticoids are not responsible for paradoxical sleep deprivation-induced memory impairments
    Paula Ayako Tiba
    Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Sleep 31:505-15. 2008
    To evaluate whether paradoxical sleep deprivation-induced memory impairments are due to release of glucocorticoids, by means of corticosterone inhibition with metyrapone.
  59. ncbi Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Eur J Neurosci 27:2250-61. 2008
    ....
  60. ncbi Neonatal endotoxin exposure modifies the acoustic startle response and circulating levels of corticosterone in the adult rat but only following acute stress
    Frederick R Walker
    University of Newcastle, School of Biomedical Sciences, University Drive, Newcastle, NSW 2308, Australia
    J Psychiatr Res 42:1094-103. 2008
    ..we observed that adult animals neonatally exposed to infection, exhibited increased production of circulating corticosterone following stress, indicating potentiated hypothalamic pituitary adrenal axis activity as well as altered ..
  61. pmc Corticosterone impairs dendritic cell maturation and function
    Michael D Elftman
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033 0850, USA
    Immunology 122:279-90. 2007
    ..b>Corticosterone (CORT), an adrenal hormone produced at increased concentrations during a stress response, has been shown to ..
  62. pmc Somatostatin receptor type 2 antagonism improves glucagon and corticosterone counterregulatory responses to hypoglycemia in streptozotocin-induced diabetic rats
    Jessica T Y Yue
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Diabetes 61:197-207. 2012
    ..0002) was fully restored by SSTR2a (P < 0.0001). Furthermore, the attenuated corticosterone response in D (P < 0.002) was also enhanced by SSTR2a (P < 0.05)...
  63. ncbi Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells
    Natasa J Stojkov
    Reproductive Endocrinology and Signaling Group, Dept of Biology and Ecology, Faculty of Sciences at Univ of Novi Sad, Dositeja Obradovica Square 2, 21000 Novi Sad, Serbia
    Am J Physiol Endocrinol Metab 302:E1239-51. 2012
    ....
  64. pmc Stress-induced memory retrieval impairments: different time-course involvement of corticosterone and glucocorticoid receptors in dorsal and ventral hippocampus
    R Dorey
    CNRS, Universités de Bordeaux, Institut de Neurosciences Cognitives et Intégratives d Aquitaine INCIA, UMR, Talence, France
    Neuropsychopharmacology 37:2870-80. 2012
    ..Thus, we studied the temporal involvement of corticosterone and its receptors, i.e...
  65. ncbi Pain behavior and spinal cell activation due to carrageenan-induced inflammation in two inbred rat strains with differential hypothalamic-pituitary-adrenal axis reactivity
    Pierre Eric Juif
    Laboratory of Neurophysiology and Psychobiology, University of Luxembourg, 162A, avenue de la Faiencerie, L 1511 Luxembourg, Luxembourg
    Physiol Behav 105:901-8. 2012
    ..At that time a higher amount of activated nociceptive neurons and corticosterone was seen in FIS rats, but microglial activation was more pronounced in LEW rats...
  66. pmc Stressor-like effects of c-Jun N-terminal kinase (JNK) inhibition
    Melanie Clarke
    Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    PLoS ONE 7:e44073. 2012
    ..We presently found that the JNK antagonist, SP600125, (but not the p38 antagonist, SB203580) increased plasma corticosterone levels under resting conditions and in the context of an acute stressor (wet bedding + restraint)...
  67. pmc Acute glucocorticoid administration rapidly suppresses basal and stress-induced hypothalamo-pituitary-adrenal axis activity
    Marcus H Andrews
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, United Kingdom
    Endocrinology 153:200-11. 2012
    ..undertaken in rats to determine the effects of acute glucocorticoid administration on basal and stress-induced corticosterone secretion...
  68. ncbi Chronic ω-3 fatty acids supplementation promotes beneficial effects on anxiety, cognitive and depressive-like behaviors in rats subjected to a restraint stress protocol
    Anete Curte Ferraz
    Laboratorio de Neurofisiologia, Departamento de Fisiologia, Universidade Federal do Parana, 81 531 990 Curitiba, PR, Brazil
    Behav Brain Res 219:116-22. 2011
    ..Lastly, plasmatic corticosterone levels were demonstrated to be drastically increased by the restraint stress; however, PUFAs supplementation ..
  69. ncbi Estradiol rapidly rescues synaptic transmission from corticosterone-induced suppression via synaptic/extranuclear steroid receptors in the hippocampus
    Yuuki Ooishi
    Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3 8 1 Komaba, Meguro, Tokyo 153 8902, Japan
    Cereb Cortex 22:926-36. 2012
    We investigated rapid protection effect by estradiol on corticosterone (CORT)-induced suppression of synaptic transmission...
  70. ncbi Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone
    M J Schaaf
    Leiden Amsterdam Center for Drug Research, Division of Medical Pharmacology, Sylvius Laboratories, P O Box 9503, 2300 RA, Leiden, The Netherlands
    Brain Res 813:112-20. 1998
    Previously, we showed that corticosterone regulates BDNF mRNA levels in the hippocampus. In the present study, we have investigated the time course and dose-dependency of this effect at both the mRNA and the protein level...
  71. ncbi Gestational and postpartum corticosterone exposure to the dam affects behavioral and endocrine outcome of the offspring in a sexually-dimorphic manner
    Susanne Brummelte
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada
    Neuropharmacology 62:406-18. 2012
    ..We created an animal model of postpartum stress/depression based on administering high levels of corticosterone (CORT) to the dams during the postpartum period which caused behavioral changes and reduced hippocampal cell ..
  72. ncbi Intrahypothalamic estradiol modulates hypothalamus-pituitary-adrenal-axis activity in female rats
    J Liu
    Chinese Academy of Science Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Jinzhai Road 96, Hefei 230026, Anhui, People s Republic of China
    Endocrinology 153:3337-44. 2012
    ..intracerebroventricularly, and by intrahypothalamic microdialysis to ovariectomized rats to measure plasma corticosterone (CORT) concentrations from carotid artery blood...
  73. ncbi Fructose-induced hypothalamic AMPK activation stimulates hepatic PEPCK and gluconeogenesis due to increased corticosterone levels
    Andrezza Kinote
    Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Alexander Fleming Street, 101, 13084 971Campinas SP, Brazil
    Endocrinology 153:3633-45. 2012
    ..We also found that fructose increased corticosterone levels through a mechanism that is dependent on hypothalamic AMPK activation...
  74. ncbi The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion
    Nikolaos P Daskalakis
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, Gorlaeus Laboratories, The Netherlands
    Horm Behav 60:165-76. 2011
    Adrenal corticosterone secretion of newborn mice rapidly desensitizes to repeated maternal absence. The present study investigated the effects of novelty exposure, maternal care and genotype on this phenomenon...
  75. ncbi Prenatal stress in birds: pathways, effects, function and perspectives
    Rie Henriksen
    Behavioural Biology, Institute of Behavioural Neuroscience, University of Groningen, The Netherlands
    Neurosci Biobehav Rev 35:1484-501. 2011
    ..We critically review prenatal corticosterone mediated effects in birds by reviewing both studies were females had elevated levels of plasma corticosterone ..
  76. pmc Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors
    Gretchen L Hermes
    Departments of Comparative Human Development, Institute for Mind and Biology, The University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:22393-8. 2009
    ..Isolates, however, did develop significant dysregulation of corticosterone responses to everyday stressors manifest in young adulthood, months before tumor development, and persisting ..
  77. ncbi The effect of automated blood sampling on corticosterone levels, body weight and daily food intake in permanently catheterized male BALB/c mice
    Anne Charlotte Teilmann
    Department of Experimental Medicine, University of Copenhagen, Blegdamsvej 3b, DK 2200 Copenhagen N, Denmark
    In Vivo 26:577-82. 2012
    ..Since this technique has not been thoroughly investigated in mice, the present study was designed to evaluate this technology in mice...
  78. ncbi Modulation of aggression in male mice: influence of group size and cage size
    P L Van Loo
    Department of Laboratory Animal Science, Utrecht University, PO Box 80 166, 3508 TD, Utrecht, Netherlands
    Physiol Behav 72:675-83. 2001
    ..Furthermore, urine corticosterone levels, food and water intake, body weight, and number of wounds were measured weekly...
  79. ncbi Exogenous corticosterone induces the expression of the clock protein, PERIOD2, in the oval nucleus of the bed nucleus of the stria terminalis and the central nucleus of the amygdala of adrenalectomized and intact rats
    Lauren A Segall
    Center for Studies in Behavioral Neurobiology FRSQ Groupe de Recherche en Neurobiologie Comportementale, Department of Psychology, Concordia University, Montreal, Quebec H4B1R6, Canada
    J Mol Neurosci 42:176-82. 2010
    ..regions of the limbic forebrain is contingent upon the rhythmic secretion of the adrenal glucocorticoid, corticosterone. Daily rhythmic PER2 expression in the oval nucleus of the bed nucleus of the stria terminalis (BNSTov) and ..
  80. ncbi Neonatal lipopolysaccharide exposure impairs sexual development and reproductive success in the Wistar rat
    Adam K Walker
    Laboratory of Neuroimmunology, School of Psychology, The University of Newcastle, Callaghan, Australia
    Brain Behav Immun 25:674-84. 2011
    ..Neonatal LPS exposure induced a significant increase in corticosterone compared to controls, as well as reduced testosterone and LH in males and LH in females immediately following ..
  81. ncbi Activation of stress-related hypothalamic neuropeptide gene expression during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University of Murcia, Murcia, Spain
    J Neurochem 101:1060-71. 2007
    ..in the hypothalamus of morphine-dependent rats during naloxone precipitated opioid withdrawal, we measured corticosterone secretion, c-Fos induction and heteronuclear (hn)RNA levels of corticotropin-releasing hormone (CRH) and ..
  82. ncbi Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain
    T Rouwette
    Department of Cellular Animal Physiology, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Neuroscience 183:15-24. 2011
    ..the PVN, CRF-immunoreactivity was minimal at 60 min after APS and concomitant with a marked increase in plasma corticosterone, whereas in the BSTov not CRF peptide but CRF mRNA peaked at 60 min, and in the CeA a surge of CRF peptide ..
  83. ncbi Increased corticosterone pulse frequency during adjuvant-induced arthritis and its relationship to alterations in stress responsiveness
    R J Windle
    Department of Medicine, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    J Neuroendocrinol 13:905-11. 2001
    ..In control rats, corticosterone release occurred in a series of 13 +/- 1 pulses per 24 h...
  84. ncbi Memory-enhancing corticosterone treatment increases amygdala norepinephrine and Arc protein expression in hippocampal synaptic fractions
    Jayme R McReynolds
    School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080 3021, USA
    Neurobiol Learn Mem 93:312-21. 2010
    ..In the present experiments corticosterone (3 mg/kg, i.p...
  85. pmc Disengaging insulin from corticosterone: roles of each on energy intake and disposition
    James P Warne
    Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1366-75. 2009
    b>Corticosterone and insulin play complex roles in the amount and composition of calories ingested, and the utilization and deposition of this energy...
  86. ncbi Stress and epilepsy: multiple models, multiple outcomes
    Nikki T Sawyer
    Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
    J Clin Neurophysiol 27:445-52. 2010
    ..The growing availability of genetically modified mice that carry either human epilepsy mutations or mutations in stress pathway genes now provide the opportunity to examine the relationship between stress and epilepsy more directly...
  87. ncbi Plasticity in the adrenocortical response of a free-living vertebrate: the role of pre- and post-natal developmental stress
    Oliver P Love
    Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, V5A 1S6 Canada
    Horm Behav 54:496-505. 2008
    ..that mimicking a hormonal signal of poor maternal condition via an experimental pre-natal increase in yolk corticosterone decreased the subsequent responsiveness of the HPA axis in fledglings...
  88. ncbi Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase
    Daniela Rogoff
    University of Texas Southwestern Medical Center, 5223 Harry Hines Boulevard, Dallas, TX 75390 9063, USA
    Endocrinology 148:5072-80. 2007
    ..146), which converts hormonally inactive cortisone to active cortisol (in rodents, 11-dehydrocorticosterone to corticosterone)...
  89. ncbi Stress during development alters anxiety-like behavior and hippocampal neurotransmission in male and female rats
    Jair B Barbosa Neto
    Departamento de Psiquiatria, Universidade Federal de Sao Paulo, Brazil
    Neuropharmacology 62:518-26. 2012
    ..we sought to investigate the long-term behavioral and neurochemical consequences of increased and sustained corticosterone levels induced by a 24 h bout of maternal deprivation (DEP) imposed on postnatal day 11 (DEP11)...
  90. ncbi Sex-dependent and differential responses to acute restraint stress of corticotropin-releasing factor-producing neurons in the rat paraventricular nucleus, central amygdala, and bed nucleus of the stria terminalis
    Linda Sterrenburg
    Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
    J Neurosci Res 90:179-92. 2012
    ..Compared with females, male rats responded to the stressor with a stronger rise in corticosterone titer and a stronger increase in neuronal contents of c-Fos, CRF mRNA, and CREB-binding protein mRNA in the ..
  91. pmc Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions
    Daniel Louis Albert van den Hove
    Institute of Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 6:e22715. 2011
    ..Moreover, hippocampal gene expression profiles suggest that distinct molecular mechanisms mediate the behavioral effects of the 5-Htt genotype, PS exposure, and their interaction...
  92. pmc A rapid release of corticosteroid-binding globulin from the liver restrains the glucocorticoid hormone response to acute stress
    Xiaoxiao Qian
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, University of Bristol, Bristol BS1 3NY, United Kingdom
    Endocrinology 152:3738-48. 2011
    ..using a dual-probe in vivo microdialysis method, that in rats, the forced-swim stress-induced rise in free corticosterone (its major glucocorticoid hormone) is strikingly similar in the blood and in target compartments such as the ..
  93. ncbi Early adversity and serotonin transporter genotype interact with hippocampal glucocorticoid receptor mRNA expression, corticosterone, and behavior in adult male rats
    Hiwote Belay
    Department of Biology, University of Toronto at Mississauga, 3359 Mississauga Road N, Mississauga, Ontario, Canada
    Behav Neurosci 125:150-60. 2011
    ..We found significant genotype by prenatal stress interactions for hippocampal GR mRNA levels and for the corticosterone stress responses in adulthood...
  94. pmc Testing independent and interactive effects of corticosterone and synergized resmethrin on the immune response to West Nile virus in chickens
    Mark D Jankowski
    Molecular and Environmental Toxicology Center and Zoology Department, University of Wisconsin Madison, 1300 University Avenue, 1530 MSC, Madison, WI 53706, USA
    Toxicology 269:81-8. 2010
    ..As a start, this study indicates that SR can alter some immunological parameters, but with limited consequences to primary WNV infection outcome, and that elevated CORT mildly enhances SRs immunotoxicity in chickens...
  95. ncbi Neonatal lipopolysaccharide exposure alters central cytokine responses to stress in adulthood in Wistar rats
    A K Walker
    Laboratory of Neuroimmunology, School of Psychology, The University of Newcastle, Callaghan, NSW 2308, Australia
    Stress 13:506-15. 2010
    ..from all rats at baseline, 30, 60 and 90 min after "stress", "no stress" treatment to assess peripheral corticosterone responses, and brains were collected 180 min following baseline to assess hippocampal content of interleukin-..
  96. ncbi Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus
    Olof Wiegert
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Learn Mem 13:110-3. 2006
    ..These effects are, at least in part, mediated by corticosteroid hormones. Here we demonstrate that corticosterone rapidly facilitates synaptic potentiation in the mouse hippocampal CA1 area when high levels of the hormone ..
  97. ncbi Adrenal splanchnic innervation contributes to the diurnal rhythm of plasma corticosterone in rats by modulating adrenal sensitivity to ACTH
    Yvonne M Ulrich-Lai
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1128-35. 2006
    ..Splanchnic nerve transection disrupts the diurnal rhythm in plasma corticosterone; however, there is a controversy as to whether the nerve-mediated effect is 1) via inhibition in the AM vs...
  98. ncbi Lack of vasopressin does not prevent the behavioural and endocrine changes induced by chronic unpredictable stress
    Janos Varga
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Szigony, Hungary
    Brain Res Bull 84:45-52. 2011
    ..by typical somatic (body weight reduction, thymus involution) and endocrine changes (resting plasma ACTH and corticosterone elevation and POMC mRNA elevation in anterior lobe of the pituitary)...
  99. pmc Fecal corticosterone, body mass, and caching rates of Carolina chickadees (Poecile carolinensis) from disturbed and undisturbed sites
    Jeffrey R Lucas
    Department of Biological Sciences, 915 W State Street, Purdue University, West Lafayette, IN 47907, USA
    Horm Behav 49:634-43. 2006
    ..We measured fecal corticosterone and body mass levels in the field, and fecal corticosterone, body mass, and caching behavior in an aviary ..
  100. ncbi A heterozygous deletion in the glutamate decarboxylase 67 gene enhances maternal and fetal stress vulnerability
    Taku Uchida
    Department of Physiology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Neurosci Res 69:276-82. 2011
    ..0-17.5. The stress hormone (corticosterone) level of pregnant GAD67(+/GFP) mice (the overall GABA content is reduced because of the destruction of one ..
  101. ncbi Seasonal modulation of sickness behavior in free-living northwestern song sparrows (Melospiza melodia morphna)
    Noah T Owen-Ashley
    Department of Biology, Box 351800, University of Washington, Seattle, WA 98195 1800, USA
    J Exp Biol 209:3062-70. 2006
    ..as wintering sparrows were significantly heavier and had larger subcutaneous fat reserves and lower baseline corticosterone levels than breeding birds...

Research Grants73

  1. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
    ..Chronic stress-induced, corticosterone (CORT)-mediated epigenetic changes are region- and cell-specific, and "hardwired" to nociceptive DRGs ..
  2. Understanding Pain of Gastrointestinal Origin in Women that Serve in OEF/OIF
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..Furthermore, corticosterone-induced stimulation of the amygdala, a key central nuclei involved in the emotional expression of fear and ..
  3. Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSD
    DAVID MARK DIAMOND; Fiscal Year: 2013
    ..We will evaluate whether our psychosocial stress regimen produces a PTSD-like phenotype in corticosterone responses, glucocorticoid receptors and CRF levels in the hypothalmus, hippocampus and amygdala...
  4. Glucocorticoids, Stress and Blood Pressure Regulation
    Deborah A Scheuer; Fiscal Year: 2013
    ..and our preliminary results, we have formulated the hypothesis that the naturally occurring glucocorticoid corticosterone (Cort) acts via both mineralocorticoid (MR) and glucocorticoid (GR) receptors to modulate stress ..
  5. Sleep in Rats: From Conceptualization to Measurement, Analysis and Interpretation
    Gayle Giboney Page; Fiscal Year: 2010
    ..Plasma corticosterone levels are to be assessed at preoperative baseline, immediately after the first and final exposure to social ..
  6. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Furthermore, we observed increased plasma leptin, corticosterone, aldosterone and renin activity in MS rats...
  7. Effect of constitutive Type 2 NF-kB on adipogenesis
    LOTUS KYI LOO; Fiscal Year: 2010
    ..TRAF3 null mice have greatly reduced serum glucose levels, elevated serum corticosterone and no brown fat...
  8. Early Life Stress &Chronic Control of Blood Pressure
    Analia Loria; Fiscal Year: 2013
    ..Furthermore, we observed increased plasma leptin, corticosterone, aldosterone and renin activity in MS rats...
  9. Central Mechanisms Modulating Visceral Sensitivity
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..of IBS, namely anxiety accompanied by colonic hypersensitivity induced by either i) direct application of corticosterone micropellets onto the central nucleus of the amygala (CeA) or ii) repeated water avoidance stress (WAS), we ..
  10. Stress and Visceral Hyperalgesia: Epigenetic Mechanisms
    John W Wiley; Fiscal Year: 2012
    ..hypothalamic- pituitary-adrenal axis resulting in increased blood levels of the hormone cortisol in humans and corticosterone (CORT) in rodents which regulate gene expression via the intracellular corticoid receptors GR and MR...
  11. Adolescent Alcohol,Dysregulated Stress System, and PTSD Vulnerability
    GERHARD H SCHULTEIS; Fiscal Year: 2013
    ..exaggerated startle);2) intracranial self-stimulation (ICSS) reward threshold deficits (anhedonia);4) plasma corticosterone (hypocortisolism)...
  12. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
    ..both basal and dexamethasone/corticotropine releasing hormone (DEX/CRH)- induced increase of plasma corticosterone (CORT) levels during chronic stage of epilepsy (8-12 weeks after SE)...
  13. RNA editing in a transgenic mouse model of behavioral despair and anxiety.
    Minati Singh; Fiscal Year: 2010
    ..ADAR2 transgenic mice have normal plasma glucose, insulin and leptin levels but they have elevated levels of corticosterone. Most provocative is that when compared with age and weight-matched control littermates, ADAR2 transgenic mice ..
  14. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
    ..fear- and anxiety-like behavior (acoustic startle and defensive freezing), neuroendocrine responses (serum corticosterone and adrenocorticotropin hormone), and changes in mRNA expression of CGRP, and the CGRP receptor components ..
  15. Metabolic and Energetic Consequences of Fatherhood
    Wendy Saltzman; Fiscal Year: 2013
    ..mass, body composition), energetic (resting and maximal metabolic rates, daily energy expenditure), hormonal (corticosterone, testosterone), and behavioral (ingestive behavior, activity levels) measures...
  16. GR-Mediated Epigenetic Regulation of the CRH Gene
    ROSALIE MARIE UHT; Fiscal Year: 2013
    ..patterns of coregulators and histone modification enzymes will be assessed at the circadian peak and trough of corticosterone (Cort)...
  17. The role of stress and mast cells in a preclinical mouse model of migraine
    ANN CHRISTINE RADDANT; Fiscal Year: 2013
    ..stress-induced light aversion is apparently not due to the hypothalamic-pituitary-adrenal axis because corticosterone levels were similar in both transgenics and controls...
  18. Neurobiology of Social Support
    CAROL SUE CARTER; Fiscal Year: 2010
    ..responses (measured by brain microdialysis, cFos and immunocytochemistry, and blood levels of OT, AVP and corticosterone)...
  19. The Role of Stress in a Genetically Predisposed Epilepsy Model
    NIKKI TAMARA SAWYER; Fiscal Year: 2013
    ..of the hypothalamic-pituitary-adrenal (HPA) axis in the R1648H mutant mice by measuring plasma levels of corticosterone, a major stress hormone, in both the morning and evening...
  20. Modeling Individual Differences in PTSD
    Marlene A Wilson; Fiscal Year: 2013
    ..markers that can be easily assayed in both rodent and human populations, including circulating levels of NPY, corticosterone (CORT) as a measure of HPA activity, cytokines as markers of immune function, and indices of sympathetic ..
  21. Determining the role of RFRP-3 in stress-related female infertility
    MOLLY JOANNE DICKENS; Fiscal Year: 2013
    ..will learn to utilize viral vectors to express a type of GR that disrupts the stress-induced signal from corticosterone (the main stress hormone in rodents) thus precisely analyzing the role of this hormone at the level of RFRP-3 ..
  22. Mechanisms of social-stress enhanced allergic airway response in a mouse model
    Angela Haczku; Fiscal Year: 2013
    ..By investigating GR and NF-?B expression and DNA binding in corticosterone treated dendritic and T cells, we will define whether corticosteroid insensitivity requires GR downregulation ..
  23. Increased vulnerability of BDNF deficient mice to mild stress
    JULIE GORTON HENSLER; Fiscal Year: 2010
    ..We will measure plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone as a physiological indication of the reactivity of BDNF() mice to stress immediately following the acute (3 ..
  24. Neural circuits underlying circadian regulation of behavior and physiology
    Nina Vujovic; Fiscal Year: 2012
    ..To assess the role of glutamate in DMH modulation of circadian rhythms in activity, sleep, feeding, T{b} and corticosterone release - by injecting an adeno-associated viral vector expressing Cre- recombinase into the DMH of ..
  25. Early Life Stress and Corticosterone Signaling: Relation to Ethanol Drinking
    TRACY RENEE BUTLER; Fiscal Year: 2013
    ..are designed to investigate physiological and neurobiological consequences related to HPA axis dysfunction and corticosterone (CORT) in a well-established model of chronic early life stress produced by adolescent social isolation (SI)...
  26. Neurobiological Correlates of Stress and Norepinephrine Transporter
    Meng Yang Zhu; Fiscal Year: 2012
    ..are also found in rats and cultured cells, which were treated with or exposed to stress-relevant doses of corticosterone. These findings suggest that stress-induced alterations of NET may serve as the point of entry for stress-..
  27. Induced immunity as a source of maternal effects on offspring phenotype
    Charles Thompson; Fiscal Year: 2013
    ..stimulation of the maternal immune system leads to increased production of the avian stress hormone, corticosterone, that is transferred to the developing embryo in the egg...
  28. The Role of Gonadotrope in Stress-Induced Reproductive Impairment
    Kellie M Breen; Fiscal Year: 2013
    ..Three specific aims are proposed to: 1) Test the hypothesis that the chronic inhibitory effect of corticosterone is transduced genomically via a reduction in gonadotropin gene transcription, whereas the acute effect of ..
  29. Circuitry for circadian rhythms
    Clifford B Saper; Fiscal Year: 2013
    ..circadian cycles of locomotor activity, body temperature, feeding, wake-sleep, and secretion of melatonin and corticosterone, and determine the extent to which these depend upon either GABAergic transmission from the SCN, SPZ, or DMH, ..
  30. Physiological Factors Driving Maturation of Neonatal Beta Cells
    Susan Bonner-Weir; Fiscal Year: 2013
    ..of these changes: at P1 blood glucose levels are low, as are levels of thyroid hormones (T3 and T4), of corticosterone (the main glucocorticoid of the rat) and of prolactin, and the diet is only milk...
  31. Synaptic Changes by Stress in Prefrontal Cortex
    Zhen Yan; Fiscal Year: 2013
    ..The function of PFC is strongly influenced by corticosterone, the major stress hormone released from adrenal cortex in response to stressful events, but the underlying ..
  32. Hypothalamic Neuronal Plasticity in Chronic Stress
    De Pei Li; Fiscal Year: 2013
    ..parvocellular neurons increases pituitary adrenocorticotropic hormone (ACTH) release and subsequent corticosterone (CORT) secretion under both basal and stressed conditions...
  33. Sex Differences in Stress-Induced Genome-Wide Transcriptional Profiles
    Scott J Russo; Fiscal Year: 2013
    ..on the splash test, increased latency to feed on novelty suppressed feeding (NSF), and increased serum corticosterone levels...
  34. Early Life Experience Shapes Visceral Circuits
    LINDA M RINAMAN; Fiscal Year: 2013
    ..plus maze, and blood samples will be collected to document restraint stress-evoked excursions in plasma corticosterone. Subsequent experiments in Aims 1 and 2 will be performed in behaviorally- and hormonally-screened adult rats...
  35. CNS Mechanisms that Modulate Reward
    Kenneth D Carr; Fiscal Year: 2013
    ..Aim 3 will determine the role of a likely regulatory factor linking effects of drug abuse and diet, which is corticosterone. It is expected that understanding these neuroadaptations and their recruitment by drugs of abuse will ..
  36. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
    ..HPA) axis function in response to fear-conditioning in HAP/LAP lines by measuring corticosterone response profiles and to examine the effect of exogenous corticosterone administration on the acquisition of ..
  37. Homeostatic regulation of peripheral oscillators via autonomic circuitry
    PATRICIA SOLLARS; Fiscal Year: 2013
    ..Rhythmic corticosterone (CORT) signals induce the rhythmic expression of a diverse array of genes including clock genes...
  38. The impact of HPA axis dysregulation on the interoceptive effects of alcohol
    Joyce Besheer; Fiscal Year: 2013
    ..Using a model of repeated HPA axis activation (corticosterone (CORT) in the drinking water) that results in HPA axis dysregulation, we show reduced sensitivity to the ..
  39. Mechanism of HPA Axis Activation: Role of Nicotinic Acid Receptor in the Brain
    Jang H Youn; Fiscal Year: 2012
    ..We will also examine the effects of starvation and diabetes on plasma [unreadable]HB, ACTH, and corticosterone levels in wild-type and NA-R knockout mice and test whether the HPA axis is activated in wild-type, but not in ..
  40. Tat mediation of HIV-associated mood disorders via functional deficits in brain
    Jay P McLaughlin; Fiscal Year: 2013
    ..Additionally, we will use BOLD functional MRI with corticosterone challenge to identify functional changes in brain regions associated with mood disorders resulting from ..
  41. The Role of HDAC6 and Glucocorticoid Signaling in Resilience to Depression
    Sarah L Teegarden; Fiscal Year: 2011
    ..We will also examine differences in corticosterone-induced behavioral changes in mice lacking HDAC6 specifically in serotonin neurons...
  42. The Role of the Maternal and Developmental Environments in Adult Phenotype
    JENNIFER GRINDSTAFF; Fiscal Year: 2010
    ..Finally manipulation of exposure to both endotoxin and corticosterone will isolate the effects of exposure to an inflammatory stimulus and associated activation of the hypothalamic-..
  43. Mechanisms Underlying Stress-Induced Activation of Serotonergic Systems
    Christopher A Lowry; Fiscal Year: 2012
    ..detection" is glucocorticoid-mediated blockade of NE clearance by the low-affinity, high-capacity, corticosterone-sensitive transporter, organic cation transporter 3 (OCT3)...
  44. MORPHINE ACTIONS ON THE IMMUNE SYSTEM
    Sulie L Chang; Fiscal Year: 2012
    ..releasing factor mRNA by the hypothalamus and decreasing the production of anti-inflammatory agents, such as corticosterone, by the adrenal gland...
  45. Effects of food deprivation on sexual behavior
    MICHAEL FERKIN; Fiscal Year: 2009
    ..of glucose utilization and lipid utilization on sexual behavior;3) changes in steroid hormone concentrations (corticosterone, testosterone, and estradiol) that accompany food deprivation;4) the role of these steroid hormones in ..
  46. NEUROPEPTIDES AND THEIR PHYSIOLOGICAL CONTROL
    Alan G Watts; Fiscal Year: 2013
    ..The pre-motor Glu/GABA network is necessary for catecholaminergic activation of CRH neurons;3) Corticosterone targets the pre-motor network to shift the balance away from [unreadable]1 adrenoreceptor actions in CRH ..
  47. A Genetic Basis for Stress-Neuroendocrine-Immune Interactions
    SARAH ELIZABETH REBSTOCK; Fiscal Year: 2013
    ..Activation of the hypothalamic-pituitary-adrenal (HPA) axis and the production of corticosterone/cortisol is a major mediator of stress-induced effects on immune function and is modulated, in part, by the [..
  48. The role of traumatic brain injury stress response on exercise therapy
    Grace Sophia Griesbach; Fiscal Year: 2012
    ..The first experiments within this proposal will determine if injury induced alterations in levels of corticosterone (CORT) play a key role in the disruption of BDNF mediated neuroplasticity during different post-TBI time ..
  49. DRUGS OF ABUSE AND LEARNED AVERSIONS: SOLVING A PARADOX
    Patricia Sue Grigson; Fiscal Year: 2013
    ..Avoidance of the taste cue is associated with an elevation of the stress hormone, corticosterone, and blunting of the accumbens dopamine peak that normally accompanies ingestion of the sweet taste cue...
  50. Biomarkers of aging in a free-ranging primate population
    Dario Maestripieri; Fiscal Year: 2009
    ..subjects will be observed on a weekly basis and fecal samples will be collected and assayed for cortisol and corticosterone. Hormone concentrations will be used as potential predictors of interindividual variation in aging biomarkers ..
  51. Sex differences in stress-alcohol interactions modulating amygdala activity
    MARIAN LEE LOGRIP; Fiscal Year: 2013
    ..underlie alcohol dependence? This proposal will address one possible mechanism, involving the stress hormone corticosterone and the novel putative downstream effector PDE10A...
  52. REGULATION OF HIPPOCAMPAL NEUROGENESIS BY ANTIDEPRESSANTS
    Irwin Lucki; Fiscal Year: 2013
    ..The primary goals of this proposal are: 1) demonstrate the critical role of exposure to corticosterone (CORT) in augmenting responses to chronic treatment with antidepressant drugs on neurogenesis and behavior in ..
  53. Phagocytosis of dying cells, adult neurogenesis and depression
    Kodi S Ravichandran; Fiscal Year: 2013
    ..Third, we note a strong inhibition of engulfment by corticosterone, which is elevated with depression;conversely, the antidepressant drug fluoxetine enhances phagocytosis of ..
  54. Resonance Aided Insertion Lancet for serial blood sampling in age-related studies
    Ryan S Clement; Fiscal Year: 2010
    ..The study suggested that blood samples were obtained with less stress according to behavioral indicators and corticosterone levels, compared to that of conventional manual lancet insertion...
  55. REGULATION OF HIPPOCAMPAL NEUROGENESIS BY ANTIDEPRESSANTS
    Irwin Lucki; Fiscal Year: 2009
    ..The primary goals of this proposal are: 1) demonstrate the critical role of exposure to corticosterone (CORT) in augmenting responses to chronic treatment with antidepressant drugs on neurogenesis and behavior in ..
  56. Glucocorticoid mechanisms of neonatal separation effects on adult learning
    Aaron A Wilber; Fiscal Year: 2009
    ..In addition, perinatal corticosterone exposure influences development of several brain structures, including the cerebellum, and the effects we ..
  57. Glucocorticoid and Stress Induced Cerebellar Neural Progenitor Cell Apoptosis
    Kevin K Noguchi; Fiscal Year: 2013
    ..In Aim 2, the applicant will determine whether a perinatal stress paradigm associated with increased corticosterone release can produce apoptosis in cerebellar NPCs acutely and produce long term reductions in cerebellar ..
  58. Role of the Trigeminal Orosensory Area of the Thalamus in Natural and Drug Reward
    Jennifer E Nyland; Fiscal Year: 2012
    ..been paired with a drug of abuse, and this avoidance is associated with an elevation of the stress hormone, corticosterone, and blunting of the accumbens dopamine peak that normally accompanies ingestion of the sweet taste cue...
  59. NEURAL PATHWAYS FOR METABOLIC CONTROL OF INGESTION
    W SUE RITTER; Fiscal Year: 2013
    ..required for elicitation of a number of key responses to glucose deficit, including stimulation of feeding, corticosterone (CORT) and adrenal medullary secretion and suppression of reproductive responses...
  60. RAIL reduces variability and concentration of stress hormones in blood sampling
    Ryan S Clement; Fiscal Year: 2013
    ..Blood samples obtained with the RAIL prototype had on average a 60% reduction in corticosterone level. The average variance in measurements was reduced by 71%...
  61. Fine Mapping Genes for Cocaine Locomotor Response in ENU Mutagenized Mice
    Lisa M Tarantino; Fiscal Year: 2010
    ..exaggerated locomotor response to the psychostimulants cocaine and methylphenidate and a prolonged release of corticosterone following an acute stressor...
  62. Role and Mechanisms of Prolactin on HPA Axis Activation Following Stress
    James Janik; Fiscal Year: 2009
    ..Plasma corticosterone (CORT) and PRL levels will also be measured...
  63. Neural Basis of Pubertal Shifts in Stress Reactivity
    Russell D Romeo; Fiscal Year: 2012
    ..For instance, in response to an acute stressor, adrenocorticotropic hormone (ACTH) and corticosterone levels in prepubertal animals remain elevated for twice as long compared to adults...
  64. Role of OFQ/N in Regulating the Prolactin Response to Stress
    Phyllis Callahan; Fiscal Year: 2007
    ..Plasma corticosterone levels, a reliable indicator of stress activation, and plasma PRL levels will be measured...
  65. "Innate intestinal responses in murine toxoplasmosis"
    Fernando Monroy; Fiscal Year: 2005
    ..Stress activates the HPA axis and the sympathetic nervous system leading to the release of glucocorticoids (corticosterone) from the adrenal cortex, and release of catecholamines (epinephrine, nor-epinephrine) from sympathetic nerve ..
  66. Stress stimulated peptides in forced use neuroprotection
    Amanda Smith; Fiscal Year: 2003
    ..ACTH stimulates the adrenal cortex to release corticosterone (CORT)...
  67. MECHANISMS UNDERLYING ADRENAL STEROID MODULATION OF LTP
    Constantine Pavlides; Fiscal Year: 2000
    ..Originally, the stress induced suppression in LTP was correlated with elevated plasma corticosterone levels, however, later studies supported the hypothesis that these effects wer probably due to elevations in ..
  68. DEVELOPMENT OF SMALL INTESTINAL EPITHELIUM
    Kwo Yih Yeh; Fiscal Year: 1990
    ..Using this model, the effects of hormones, including growth hormone, corticosterone, thyroxine and epidermal growth factor, alone or in various combinations on epithelial cell proliferation, ..
  69. OPIOID AND ALCOHOL-REGULATED IMMUNE FUNCTION
    DIPAK SARKAR; Fiscal Year: 2001
    ..The effect of corticotropin-releasing hormone and corticosterone in the control of ethanol-modulated immune function has been extensively, studied...
  70. Interleukin-6 Expression and Function in Adipose Cells
    Jianbei Deng; Fiscal Year: 2006
    ..we hypothesize that IL-6 expression is depressed in adipose tissue of ob/ob and db/db mice by high systemic corticosterone levels that are characteristic of these models of obesity...
  71. Chronic Nicotine's Activation of the HPA Axis
    Theodore Friedman; Fiscal Year: 2005
    ..Acute administration of nicotine has been shown to stimulate ACTH and corticosterone/cortisol secretion in both rodents and humans...
  72. IMMUNOSUPPRESSION IN A BINGE DRINKING MODEL
    Stephen Pruett; Fiscal Year: 1999
    ..The major focus of the candidate's laboratory is to determine the role of endogenous corticosterone in EtOH- induced suppression of humoral immune responses in a mouse model for binge drinking...
  73. HPA Axis Activation and Nicotine Use
    Theodore Friedman; Fiscal Year: 2005
    ..Acute administration of nicotine has been shown to stimulate ACTH and corticosterone/cortisol secretion in both rodents and humans...