methylprednisolone

Summary

Summary: A PREDNISOLONE derivative with similar anti-inflammatory action.

Top Publications

  1. ncbi Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial
    G Umberto Meduri
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA
    Chest 131:954-63. 2007
  2. ncbi Tonsillectomy and steroid pulse therapy significantly impact on clinical remission in patients with IgA nephropathy
    O Hotta
    Department of Nephrology, Sendai Shakaihoken Hospital, Sendai, Japan
    Am J Kidney Dis 38:736-43. 2001
  3. ncbi Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation
    Pieter J Gaillard
    to BBB technologies BV, Leiden, The Netherlands
    J Control Release 164:364-9. 2012
  4. ncbi Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph
    Philip A Bird
    Department of Otolaryngology, Head and Neck Surgery, Christchurch Hospital, New Zealand
    Otol Neurotol 28:1124-30. 2007
  5. ncbi Repeated pulse of methylprednisolone and cyclophosphamide with continuous dexamethasone therapy for patients with severe paraquat poisoning
    Ja Liang Lin
    Division of Clinical Toxicology and Nephrology, Department of Medicine, Chang Gung Memorial Hospital, Lin Kou Medical Center, Chang Gung University, School of Medicine, Taipei, Taiwan, ROC
    Crit Care Med 34:368-73. 2006
  6. ncbi Randomized, double-blind, placebo-controlled, pilot trial of high-dose methylprednisolone in aneurysmal subarachnoid hemorrhage
    Philippe Gomis
    Departement d Anesthésie Réanimation et Biostatistiques, Hopital Maison Blanche, Reims, France
    J Neurosurg 112:681-8. 2010
  7. ncbi Comparison of cyclosporine A with methylprednisolone for treatment of canine atopic dermatitis: a parallel, blinded, randomized controlled trial
    Jean Steffan
    Novartis Animal Health Inc, CH 4002, Basel, Switzerland
    Vet Dermatol 14:11-22. 2003
  8. ncbi Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of methylprednisolone
    Sean D Christie
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Neurosurg Focus 25:E5. 2008
  9. ncbi Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipopolysaccharide and methylprednisolone
    L Qin
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China
    Bone 39:863-71. 2006
  10. ncbi Effects of combining methylprednisolone with rolipram on functional recovery in adult rats following spinal cord injury
    Ying Yin
    Department of Clinical Laboratory Science, Wuxi People s Hospital of Nanjing Medical University, Wuxi, PR China
    Neurochem Int 62:903-12. 2013

Detail Information

Publications323 found, 100 shown here

  1. ncbi Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial
    G Umberto Meduri
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA
    Chest 131:954-63. 2007
    To determine the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe ARDS.
  2. ncbi Tonsillectomy and steroid pulse therapy significantly impact on clinical remission in patients with IgA nephropathy
    O Hotta
    Department of Nephrology, Sendai Shakaihoken Hospital, Sendai, Japan
    Am J Kidney Dis 38:736-43. 2001
    ..model with 13 independent covariates, initial Scr level, histological score, tonsillectomy, and high-dose methylprednisolone therapy had a significant impact on clinical remission, whereas proteinuria, age, sex, levels of hematuria, ..
  3. ncbi Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation
    Pieter J Gaillard
    to BBB technologies BV, Leiden, The Netherlands
    J Control Release 164:364-9. 2012
    ..However, their side effects are dose limiting. To optimally improve the therapeutic window of methylprednisolone, we enhanced its CNS delivery by using pegylated liposomes conjugated to the brain-targeting ligand ..
  4. ncbi Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph
    Philip A Bird
    Department of Otolaryngology, Head and Neck Surgery, Christchurch Hospital, New Zealand
    Otol Neurotol 28:1124-30. 2007
    To compare methylprednisolone concentrations in the perilymph of the human ear and in plasma after intratympanic (IT) or intravenous (IV) administration.
  5. ncbi Repeated pulse of methylprednisolone and cyclophosphamide with continuous dexamethasone therapy for patients with severe paraquat poisoning
    Ja Liang Lin
    Division of Clinical Toxicology and Nephrology, Department of Medicine, Chang Gung Memorial Hospital, Lin Kou Medical Center, Chang Gung University, School of Medicine, Taipei, Taiwan, ROC
    Crit Care Med 34:368-73. 2006
    ..severe paraquat-poisoned patients with >50% to <90% predictive mortality: initial pulse therapy with methylprednisolone (1 g/day for 3 days) and cyclophosphamide (15 mg/kg/day for 2 days), followed by dexamethasone 20 mg/day ..
  6. ncbi Randomized, double-blind, placebo-controlled, pilot trial of high-dose methylprednisolone in aneurysmal subarachnoid hemorrhage
    Philippe Gomis
    Departement d Anesthésie Réanimation et Biostatistiques, Hopital Maison Blanche, Reims, France
    J Neurosurg 112:681-8. 2010
    The object of this study was to determine the efficacy of methylprednisolone in reducing symptomatic vasospasm and poor outcomes after subarachnoid hemorrhage (SAH).
  7. ncbi Comparison of cyclosporine A with methylprednisolone for treatment of canine atopic dermatitis: a parallel, blinded, randomized controlled trial
    Jean Steffan
    Novartis Animal Health Inc, CH 4002, Basel, Switzerland
    Vet Dermatol 14:11-22. 2003
    ..study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months...
  8. ncbi Duration of lipid peroxidation after acute spinal cord injury in rats and the effect of methylprednisolone
    Sean D Christie
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Neurosurg Focus 25:E5. 2008
    ..The objectives of this study were to determine the duration of lipid peroxidation following acute SCI and the efficacy of short-and long-term administration of methylprednisolone on decreasing lipid peroxidation.
  9. ncbi Multiple bioimaging modalities in evaluation of an experimental osteonecrosis induced by a combination of lipopolysaccharide and methylprednisolone
    L Qin
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, PR China
    Bone 39:863-71. 2006
    ..extravascular events attributing to steroid-associated osteonecrosis (ON) using an experimental protocol with a single low-dose lipopolysaccharide (LPS) injection and subsequently three injections of high-dose methylprednisolone (MPS).
  10. ncbi Effects of combining methylprednisolone with rolipram on functional recovery in adult rats following spinal cord injury
    Ying Yin
    Department of Clinical Laboratory Science, Wuxi People s Hospital of Nanjing Medical University, Wuxi, PR China
    Neurochem Int 62:903-12. 2013
    b>Methylprednisolone (MP) has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (SCI)...
  11. pmc Effect of tonsillectomy plus steroid pulse therapy on clinical remission of IgA nephropathy: a controlled study
    Hiroyuki Komatsu
    Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, 889 1692, Japan
    Clin J Am Soc Nephrol 3:1301-7. 2008
    ..A prospective, controlled study therefore was performed to compare the effects of combined therapy with those of steroid pulse alone in patients with IgA nephropathy...
  12. ncbi Early donor management increases the retrieval rate of lungs for transplantation
    Rajamiyer V Venkateswaran
    Department of Cardiothoracic Surgery Heart and Lung Transplantation Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Ann Thorac Surg 85:278-86; discussion 286. 2008
    ..Lung transplantation activity is frustrated by donor lung availability. We sought to examine the effect of active donor management and hormone administration on pulmonary function and yield in cadaveric heart-beating potential lung donors...
  13. pmc Acute glucocorticoid administration rapidly suppresses basal and stress-induced hypothalamo-pituitary-adrenal axis activity
    Marcus H Andrews
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, United Kingdom
    Endocrinology 153:200-11. 2012
    ..The glucocorticoid agonist methylprednisolone (5-2000 μg) or dexamethasone (5-500 μg) injected iv at the peak of the diurnal rhythm caused dose-..
  14. ncbi The mechanism of action of methylprednisolone in the treatment of multiple sclerosis
    J S Sloka
    Faculty of Medicine Neurology, Memorial University of Newfoundland, NL, Canada
    Mult Scler 11:425-32. 2005
    b>Methylprednisolone plays an important role in the current treatment of multiple sclerosis (MS), particularly in the acute phase of relapse...
  15. ncbi Changes of the MS functional composite and EDSS during and after treatment of relapses with methylprednisolone in patients with multiple sclerosis
    T Patzold
    Department of Neurology, BG Kliniken Bergmannsheil, Ruhr University Bochum, FRG
    Acta Neurol Scand 105:164-8. 2002
    ..We examined the responsiveness of the MSFC compared with the Expanded Disability Status Scale (EDSS) during treatment of relapses in patients with multiple sclerosis (MS)...
  16. pmc Etanercept plus methylprednisolone as initial therapy for acute graft-versus-host disease
    John E Levine
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA
    Blood 111:2470-5. 2008
    ..We conclude that etanercept plus steroids as initial therapy for acute GVHD results in a substantial majority of CRs. This trial was referenced at www.clinicaltrials.gov as NCT00141713...
  17. pmc Human infection with highly pathogenic avian influenza virus (H5N1) in northern Vietnam, 2004-2005
    Nguyen Duc Hien
    National Institute of Infectious and Tropical Diseases, Hanoi, Vietnam
    Emerg Infect Dis 15:19-23. 2009
    ..24), respectively, and were 33.3% (5/15) and 14.2% (2/14) among patients treated with and without methylprednisolone (p = 0.39), respectively...
  18. ncbi Prophylactic treatment of episodic cluster headache with intravenous bolus of methylprednisolone
    P Mir
    Department of Neurology, University Hospital Virgen del Rocio, Avda Manuel Siurot s n, 41013 Seville, Spain
    Neurol Sci 24:318-21. 2003
    We evaluated the efficacy of intravenous boluses of methylprednisolone followed by prednisone as a prophylactic treatment for episodic cluster headache. Fourteen male patients (mean age, 42...
  19. ncbi Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis
    G G Illei
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 10 Center Drive, Building 10, Room 9S 205, Bethesda, MD 20892, USA
    Ann Intern Med 135:248-57. 2001
    ..The long-term effectiveness and side-effect profiles of pulse immunosuppressive regimens warrant further study...
  20. pmc A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment
    Stephen L Walker
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 5:e1041. 2011
    ..b>Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the ..
  21. ncbi Methylprednisolone inhibits production of interleukin-1beta and interleukin-6 in the spinal cord following compression injury in rats
    Eugene S Fu
    Department of Anesthesiology, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurosurg Anesthesiol 17:82-5. 2005
    ..This study sought to evaluate the effects of methylprednisolone (MP) on IL-1beta and IL-6 protein in spinal cord tissue following SCI...
  22. ncbi The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats
    Antonio Ibarra
    Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Eur J Neurosci 19:2984-90. 2004
    ..As the steroid drug methylprednisolone (MP) is currently the only treatment available for patients with SCI, our purpose in the present study was ..
  23. ncbi Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre
    Toshiyuki Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1235-43. 2007
    ..Anti-AQP4 antibody titres became lower after high-dose methylprednisolone, and a follow-up showed anti-AQP4 antibody titres remained low in relapse-free periods under ..
  24. ncbi Posterior reversible encephalopathy syndrome in neuromyelitis optica spectrum disorders
    S M Magaña
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 72:712-7. 2009
    ..It has been associated with hypertensive crises and with immunosuppressive medications but not with neuromyelitis optica (NMO)...
  25. pmc Suprascapular nerve block (using bupivacaine and methylprednisolone acetate) in chronic shoulder pain
    E M Shanahan
    Rheumatology Research Unit, Repatriation General Hospital, Daw Park South Australia, Australia 5041
    Ann Rheum Dis 62:400-6. 2003
    ..There have been no large randomised placebo controlled trials examining the efficacy of suprascapular nerve block for shoulder pain in arthritis and/or degenerative disease using pain and disability end points...
  26. ncbi Methylprednisolone reduces the early vascular permeability increase in spinal nerve roots induced by epidural nucleus pulposus application
    G Byröd
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Orthop Res 18:983-7. 2000
    ..early vascular reactions and the possibility of blocking these reactions with intravenous, high-dose, methylprednisolone pretreatment. In 25 pigs, the S2 and S3 nerve roots were exposed...
  27. ncbi High efficacy of bolus methylprednisolone in severe leptospirosis: a descriptive study in Sri Lanka
    Senanayake A M Kularatne
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    Postgrad Med J 87:13-7. 2011
    ..Addition of intravenous methylprednisolone (MP) to the treatment regimen of severely ill patients was implemented on the basis of immune mediated ..
  28. ncbi Fungal infections associated with contaminated methylprednisolone in Tennessee
    Marion A Kainer
    Division of Communicable and Environmental Diseases and Emergency Preparedness, Tennessee Department of Health, 1st Fl, Cordell Hull Bldg, 425 5th Ave N, Nashville, TN 37243, USA
    N Engl J Med 367:2194-203. 2012
    ..of fungal infections of the central nervous system that occurred among patients who received epidural or paraspinal glucocorticoid injections of preservative-free methylprednisolone acetate prepared by a single compounding pharmacy.
  29. ncbi Intravenous methylprednisolone in idiopathic childhood nephrotic syndrome
    Mohan Shenoy
    Department of Paediatric Nephrology, Royal Manchester Children s Hospital, Manchester, UK
    Pediatr Nephrol 25:899-903. 2010
    ..the clinical course of children with idiopathic childhood nephrotic syndrome (ICNS) who received intravenous methylprednisolone (ivMP) following failure to achieve remission with standard oral prednisolone therapy...
  30. ncbi Complete remission within 2 years predicts a good prognosis after methylprednisolone pulse therapy in patients with IgA nephropathy
    Miho Tatematsu
    Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Clin Exp Nephrol 16:883-91. 2012
    ..Pozzi et al. reported the effectiveness of steroid pulse therapy (Pozzi's regimen) in IgA nephropathy (IgAN). The present study was performed to clarify the predictive factors for IgAN patients treated with Pozzi's regimen...
  31. ncbi Direct effect of methylprednisolone on renal sodium and water transport via the principal cells in the kidney
    Thomas G Lauridsen
    Department of Medical Research, Holstebro Hospital, University of Aarhus, Holstebro, Denmark
    Eur J Endocrinol 162:961-9. 2010
    Glucocorticoids influence renal concentrating and diluting ability. We tested the hypothesis that methylprednisolone treatment increased renal water and sodium absorption by increased absorption via the aquaporin-2 (AQP2) water channels ..
  32. ncbi Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: final results of the national cancer research institute CLL206 trial
    Andrew R Pettitt
    University of Liverpool, Liverpool, UK
    J Clin Oncol 30:1647-55. 2012
    ..TP53 defects are not associated with resistance to the anti-CD52 monoclonal antibody alemtuzumab or methylprednisolone. In an attempt to improve the treatment of TP53-defective CLL, a multicenter phase II study was developed to ..
  33. ncbi Effects of methylprednisolone and a biocompatible copolymer circuit on blood activation during cardiopulmonary bypass
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 79:655-65. 2005
    ..This trial addresses the efficacy of a biocompatible surface alone and in combination with steroids in inhibiting these changes...
  34. ncbi Evaluation of response of multiple sclerosis (MS) relapse to oral high-dose methylprednisolone: usefulness of MS functional composite and Expanded Disability Status Scale
    A M Pascual
    Department of Neurology, Hospital Universitario La Fe, Valencia, Spain
    Eur J Neurol 15:284-8. 2008
    ..after relapse was conducted among 14 multiple sclerosis (MS) patients treated with oral high-dose (1 g) methylprednisolone for 3 days. MSFC and the EDSS were assessed on day 0, before treatment and, 1, 4 and 12 weeks afterwards...
  35. ncbi Methylcobalamin, but not methylprednisolone or pleiotrophin, accelerates the recovery of rat biceps after ulnar to musculocutaneous nerve transfer
    W C Liao
    Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Neuroscience 171:934-49. 2010
    ..Here we explored whether anti-inflammatory drug- methylprednisolone, regeneration/myelination-enhancing agent- methylcobalamin and neurite growth-enhancing and angiogenic ..
  36. ncbi Melatonin effect on bone metabolism in rats treated with methylprednisolone
    Marta G Ladizesky
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Pineal Res 40:297-304. 2006
    ..melatonin (25 microg/mL of drinking water, about 500 microg/day) on a 10-wk long treatment of male rats with methylprednisolone (5 mg/kg s.c., 5 days/wk)...
  37. pmc Perioperative methylprednisolone and outcome in neonates undergoing heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC, USA
    Pediatrics 129:e385-91. 2012
    ..We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates.
  38. ncbi Intravenous immunoglobulin versus intravenous methylprednisolone for chronic inflammatory demyelinating polyradiculoneuropathy: a randomised controlled trial
    Eduardo Nobile-Orazio
    Department of Translational Medicine, Milan University, 2nd Neurology, IRCCS Humanitas Clinical Institute, Rozzano, Milan, Italy
    Lancet Neurol 11:493-502. 2012
    ..We compared the efficacy and tolerability of 6-month therapy with IVIg versus that with intravenous methylprednisolone.
  39. pmc Phase 2 trial of combined cisplatin, etoposide, gemcitabine, and methylprednisolone (PEGS) in peripheral T-cell non-Hodgkin lymphoma: Southwest Oncology Group Study S0350
    Daruka Mahadevan
    Section of Hematology, University of Arizona Arizona Cancer Center, Tucson, Arizona 85724, USA
    Cancer 119:371-9. 2013
    ..multidrug resistance gene 1/P-glycoprotein (MDR-1/P-gp), we devised platinum, etoposide, gemcitabine, and methylprednisolone (PEGS) with agents that are not substrates of the efflux pump...
  40. ncbi Randomized clinical trial of the effects of methylprednisolone on renal function after major vascular surgery
    S Turner
    Academic Unit of Anaesthesia, Leeds General Infirmary, Leeds, UK
    Br J Surg 95:50-6. 2008
    ..Studies of cardiac and hepatic transplant surgery have demonstrated beneficial effects on renal function of high-dose methylprednisolone administered before surgery.
  41. ncbi The pharmacokinetic profiles of dexamethasone and methylprednisolone concentration in perilymph and plasma following systemic and local administration
    Jun Yang
    Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Acta Otolaryngol 128:496-504. 2008
    Both methylprednisolone (MTH) and dexamethasone (DEX) could successfully and effectively penetrate the round window membrane (RWM) into perilymph...
  42. ncbi Remission of the clinical signs of atopic dermatitis in dogs after cessation of treatment with cyclosporin A or methylprednisolone
    J Steffan
    Novartis Animal Health, CH 4002 Basel, Switzerland
    Vet Rec 154:681-4. 2004
    Seventy-eight dogs with atopic dermatitis were treated for four months with either cyclosporin A or methylprednisolone. During the two months after the treatment ceased, 87 per cent of the dogs treated with methylprednisolone relapsed ..
  43. ncbi Combined initial cyclophosphamide with repeated methylprednisolone pulse therapy for severe paraquat poisoning from dermal exposure
    Nan Chieh Lin
    Poison Center, Department of Internal Medicine, Chang Gung Memorial Hospital, Lin Kou Medical Center, Chang Gung Medical College and University, Taipei, Taiwan, ROC
    J Toxicol Clin Toxicol 41:877-81. 2003
    ..treated with combined initial megadoses of cyclophosphamide (15 mg/kg/day, total 2 days) with repeated methylprednisolone pulse therapy (15 mg/kg/day, total 6 days) and continuous dexamethasone administration (5 mg every 8 hr), ..
  44. ncbi The effectiveness of combined treatment with methylprednisolone and cyclophosphamide in oral paraquat poisoning
    Saeed Afzali
    Poisoning Ward, Sina Hospital, Hamadan, Iran
    Arch Iran Med 11:387-91. 2008
    ..So, this study was designed to evaluate the effects of combined treatment with cyclophosphamide and glucocorticoids in patients with paraquat poisoning...
  45. ncbi Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions
    F M Avsar
    Ankara Numune Training Research and Hospital, Clinic of 1st Surgery, Ankara, Turkey
    Am J Surg 181:512-5. 2001
    The purpose of this study was to determine the effects of diphenhydramine hydrochloride and methylprednisolone in peritoneal adhesions.
  46. ncbi Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression
    Jamila Chakir
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie, Laval, Quebec, Canada
    J Allergy Clin Immunol 111:1293-8. 2003
    ..TGF-beta, IL-11, and IL-17 are profibrotic cytokines involved in the formation of subepithelial fibrosis and are increased in patients with asthma, particularly in those with severe disease...
  47. ncbi Autophagy is activated in injured neurons and inhibited by methylprednisolone after experimental spinal cord injury
    Hsien Chih Chen
    Department of Neurosurgery, Chang Gung Memorial Hospital, Keelung, Taiwan
    Spine (Phila Pa 1976) 37:470-5. 2012
    ..Experimental, controlled trial, animal study...
  48. ncbi Effects of dexmedetomidine or methylprednisolone on inflammatory responses in spinal cord injury
    M Can
    Department of Biochemistry, Faculty of Medicine, Karaelmas University, Zonguldak, Turkey
    Acta Anaesthesiol Scand 53:1068-72. 2009
    The aim of this study was to compare the anti-inflammatory response of methylprednisolone and the alpha2-agonist dexmedetomidine in spinal cord injury (SCI).
  49. ncbi Hearing evaluation of intratympanic methylprednisolone perfusion for refractory sudden sensorineural hearing loss
    Wandong She
    Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China
    Otolaryngol Head Neck Surg 142:266-71. 2010
    To investigate the effectiveness and safety of intratympanic methylprednisolone perfusion (IMP) through a microcatheter in patients with sudden sensorineural hearing loss (SSNHL) who failed a conventional treatment.
  50. ncbi Behçet's syndrome and the nervous system
    Aksel Siva
    Department of Neurology, Clinical Neuroimmunology Division, Cerrahpasa School of Medicine, University of Istanbul, Cerrahpasa 34303, Istanbul, Turkey
    Curr Opin Neurol 17:347-57. 2004
    ..The present review summarizes the neurological involvement in BS, and emphasizes recent clinical concepts and ethiopathogenetic findings...
  51. ncbi Successful treatment of parainfluenza virus 3 pneumonia with oral ribavirin and methylprednisolone in a bone marrow transplant recipient
    Takahiro Shima
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Int J Hematol 88:336-40. 2008
    ..in a hematopoietic stem cell transplant recipient that was successfully treated with oral ribavirin and methylprednisolone. A 42-year-old woman diagnosed with acute myelogenous leukemia (FAB M5a) in first complete remission ..
  52. ncbi Methylprednisolone and ketorolac rapidly reduce hyperalgesia around a skin burn injury and increase pressure pain thresholds
    A Stubhaug
    University of Oslo, Faculty Division Rikshospitalet, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo, Norway
    Acta Anaesthesiol Scand 51:1138-46. 2007
    ..The objectives of this study were to investigate the effects of methylprednisolone and ketorolac on hyperalgesia around a skin burn injury and on pressure pain thresholds.
  53. ncbi Improved outcomes associated with intraoperative steroid use in high-risk pediatric cardiac surgery
    Nadia A Clarizia
    The Labatt Family Heart Centre, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Ann Thorac Surg 91:1222-7. 2011
    ..Corticosteroids are commonly administered perioperatively in pediatric cardiac surgery to reduce cardiopulmonary bypass induced inflammation. However, their effects on outcomes and potential for adverse events are not well defined...
  54. ncbi Effect of acetaminophen, ibuprofen and methylprednisolone on different parameters of human osteoblast-like cells
    Olga García-Martínez
    School of Health Sciences, University of Granada, Spain
    Arch Oral Biol 56:317-23. 2011
    ..However, their effects on bone level are not well known, and results of the scant studies in humans have been contradictory...
  55. ncbi Methylprednisolone therapy in deceased donors reduces inflammation in the donor liver and improves outcome after liver transplantation: a prospective randomized controlled trial
    Katja Kotsch
    Institute of Medical Immunology, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Ann Surg 248:1042-50. 2008
    To investigate potential beneficial effects of donor treatment with methylprednisolone on organ function and outcome after liver transplantation.
  56. ncbi Comparative neuroprotective effects of methylprednisolone and rosiglitazone, a peroxisome proliferator-activated receptor-γ following spinal cord injury
    Qin Zhang
    Department of Orthopedics, First Affiliated Hospital of Soochow University, No 188 Shizi Street, Suzhou 215006, China
    Neurosciences (Riyadh) 16:46-52. 2011
    To compare the neuroprotective effects of methylprednisolone (MPSS) and rosiglitazone (ROSG) following spinal cord injury (SCI).
  57. ncbi Incidence of various cardiac arrhythmias and conduction disturbances due to high dose intravenous methylprednisolone in patients with multiple sclerosis
    Ali Vasheghani-Farahani
    Department of Cardiology, Sina Hospital, Tehran University of Medical Sciences, Hassan Abad Square, Tehran, Iran
    J Neurol Sci 309:75-8. 2011
    High-dose intravenous methylprednisolone is the most common therapeutic modality to treat acute exacerbations in multiple sclerosis (MS). Various cardiac arrhythmias have been reported during corticosteroid pulse therapy...
  58. ncbi Femoral head osteonecrosis can be caused by disruption of the systemic immune response via the toll-like receptor 4 signalling pathway
    S Okazaki
    Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Rheumatology (Oxford) 48:227-32. 2009
    ..We established a rat model with femoral head osteonecrosis by injecting lipopolysaccharide (LPS) and steroid, and assessed the consequences of this on femoral head histology, the systemic immune response and lipid synthesis...
  59. ncbi Targeted methylprednisolone acetate/hyaluronidase/clonidine injection after diagnostic epiduroscopy for chronic sciatica: a prospective, 1-year follow-up study
    Jos W Geurts
    Department of Anesthesiology, Rijnstate Hospital, Arnhem, The Netherlands
    Reg Anesth Pain Med 27:343-52. 2002
    ..We prospectively evaluated whether abnormalities at the lumbar level as diagnosed by magnetic resonance imaging (MRI) are confirmed by epiduroscopy, and assessed if targeted epidural injection of medication alleviates sciatic pain...
  60. ncbi Combined methylprednisolone and dexamethasone therapy for paraquat poisoning
    Guan Hsing Chen
    Poison Center, Chang Gung Memorial Hospital, Lin Kou Medical Center, Chang Gung Medial College and University, Taipei, Taiwan, Republic of China
    Crit Care Med 30:2584-7. 2002
    To report a severe case of paraquat poisoning successfully treated with repeated-pulse therapy of methylprednisolone.
  61. ncbi Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-alpha, IL-6, IL-8, IL-10
    Jale Bengi Celik
    Department of Cardiovascular Surgery, Meram Medical School of Selcuk University, Meram, Konya, Turkey
    Perfusion 19:185-91. 2004
    This study examined the correlation between tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-8, IL-10 and methylprednisolone pretreatment.
  62. ncbi Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial
    G U Meduri
    Baptist Memorial Hospitals, Veterans Affairs Medical Center, University of Tennessee, Memphis, USA
    JAMA 280:159-65. 1998
    ..No pharmacological therapeutic protocol has been found effective in modifying the clinical course of acute respiratory distress syndrome (ARDS) and mortality remains greater than 50%...
  63. ncbi Primary treatment of incomplete Kawasaki disease with infliximab and methylprednisolone in a patient with a contraindication to intravenous immune globulin
    Debbie Ann Shirley
    Pediatric Infectious Diseases and Tropical Pediatrics, University of Maryland Medical Center, Baltimore, MD, USA
    Pediatr Infect Dis J 29:978-9. 2010
    ..Because intravenous immune globulin infusion was not tolerated, he was treated with infliximab and methylprednisolone. Coronary aneurysms were not visualized on initial or follow-up echocardiograms...
  64. ncbi Morphological analysis of articular cartilage biopsies from a randomized, clinical study comparing the effects of 500-730 kDa sodium hyaluronate (Hyalgan) and methylprednisolone acetate on primary osteoarthritis of the knee
    D D Guidolin
    Fidia Research Laboratories, Abano Terme, Italy
    Osteoarthritis Cartilage 9:371-81. 2001
    ..The results obtained with hyaluronan were compared with the results of methylprednisolone acetate treatment.
  65. ncbi Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells: effects of rapamycin, mycophenolate, cyclosporin, azathioprine, and methylprednisolone
    Justin W G V Copeland
    Department of Renal Medicine, Auckland City Hospital, Auckland, New Zealand
    Transplantation 83:809-14. 2007
    ..Cyclosporine A, azathioprine, and methylprednisolone were less effective than rapamycin and MMF. Moreover, these immunosuppressives did not decrease versican...
  66. ncbi Protective effect of genistein aglycone on the development of osteonecrosis of the femoral head and secondary osteoporosis induced by methylprednisolone in rats
    Alessandra Bitto
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica 5th Floor, c o AOU Policlinico G Martino, Messina, Italy
    J Endocrinol 201:321-8. 2009
    ..GIO and osteonecrosis were induced by daily s.c. injections of 30 mg/kg of methylprednisolone (MP; n=7). Another group of animals (MP+GEN; n=7) concomitantly received MP (30 mg/kg per s.c...
  67. pmc Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome
    C K Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Exp Immunol 136:95-103. 2004
    ....
  68. ncbi Femoral head blood flow reduction and hypercoagulability under 24 h megadose steroid treatment in pigs
    Wolf Drescher
    Department of Orthopaedics, The Institute of Experimental Clinical Research, University Hospital, Michaelisstr 1, D 24105 Kiel, Germany
    J Orthop Res 22:501-8. 2004
    ..Blindedly, 9 animals underwent megadose methylprednisolone infusion (30 mg/kg intravenously as an initial bolus, followed by 5...
  69. ncbi Bone changes due to glucocorticoid application in an ovariectomized animal model for fracture treatment in osteoporosis
    C A Lill
    AO Research Institute Davos, Switzerland
    Osteoporos Int 13:407-14. 2002
    ..Group 2 (age 7-9 years) was ovariectomized, fed a calcium/vitamin D-restricted diet and injected with methylprednisolone (MP) over 7 months (22 weeks MP solution, 6 weeks MP suspension)...
  70. ncbi Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: a comparison study with methylprednisolone
    Sonia Messina
    Department of Neurosciences, Psychiatry and Anaesthesiology, Unit of Neurology and Neuromuscular Diseases, AOU Policlinico G Martino, 98125 Messina, Italy
    Exp Neurol 220:349-58. 2009
    ..antioxidant and NF-kappaB inhibiting properties, has beneficial effects in mdx mice in comparison with methylprednisolone, the gold standard treatment for DMD patients...
  71. ncbi Adding methylprednisolone to local anesthetic increases the duration of axillary block
    Thomas Stan
    Reg Anesth Pain Med 29:380-1. 2004
  72. ncbi Treatment of early rheumatoid arthritis: a randomized magnetic resonance imaging study comparing the effects of methotrexate alone, methotrexate in combination with infliximab, and methotrexate in combination with intravenous pulse methylprednisolone
    Patrick Durez
    Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, Brussels, Belgium
    Arthritis Rheum 56:3919-27. 2007
    To compare the effects of methotrexate (MTX), alone or in combination with intravenous (IV) methylprednisolone (MP) or infliximab, on magnetic resonance imaging (MRI)-detected synovitis, bone edema, and erosive changes in patients with ..
  73. ncbi Efficacy of methylprednisolone injected into the masseter muscle following the surgical extraction of impacted lower third molars
    E Vegas-Bustamante
    Oral Surgery and Orofacial Implantology, School of Dentistry of the University of Barcelona, Spain
    Int J Oral Maxillofac Surg 37:260-3. 2008
    The aim of this study was to demonstrate the efficacy of methylprednisolone, as a single 40-mg dose, injected into the masseter muscle upon completion of extraction of impacted lower third molars...
  74. ncbi Effects of resveratrol and methylprednisolone on biochemical, neurobehavioral and histopathological recovery after experimental spinal cord injury
    Ozkan Ates
    Department of Neurosurgery, Inonu University, School of Medicine, 44280 Malatya, Turkey
    Acta Pharmacol Sin 27:1317-25. 2006
    ..To investigate the neuroprotective effect of resveratrol in an experimental spinal cord injury (SCI) model in rats...
  75. ncbi A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathy
    Claudio Ponticelli
    Istituto Scientifico Auxologico Italiano, Milan, Italy
    Am J Kidney Dis 47:233-40. 2006
    ..We conducted a pilot trial to compare the effectiveness and safety of 2 different treatments in patients with membranous nephropathy and nephrotic syndrome...
  76. ncbi The effect of methylprednisolone treatment on the cardiopulmonary bypass-induced systemic inflammatory response
    A Bourbon
    Service de chirurgie thoracique et cardio vasculaire, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, 75013 Paris, France
    Eur J Cardiothorac Surg 26:932-8. 2004
    ..of studies have demonstrated that treatment of patients with a high-dose (30 mg/kg) of corticosteroids (methylprednisolone) attenuates the CPB-induced SIR and improves the outcome of patients undergoing cardiac surgery...
  77. ncbi Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery
    Yakup Ustun
    Cukurova University, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Adana, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:535-9. 2003
    The aim of this study was to compare the effects of intravenous administration of 1.5 mg/kg and 3 mg/kg of methylprednisolone sodium succinate (MP) on pain, swelling, and trismus after third molar surgery.
  78. ncbi Methylprednisolone infusion for life-threatening H1N1-virus infection
    Marco Confalonieri
    Pneumology Department, University Hospital of Cattinara, Str Di Fiume 447, 34149 Trieste, Italy
    Ther Adv Respir Dis 4:233-7. 2010
    ..The most severe patient was a previously healthy 30-year-old man admitted to hospital because of bilateral pneumonia and severe acute respiratory failure...
  79. ncbi Long-term effects of methylprednisolone following transection of adult rat spinal cord
    M Oudega
    The Chambers Family Electron Microscopy Laboratory, The Miami Project to Cure Paralysis, University of Miami School of Medicine, Florida, USA
    Eur J Neurosci 11:2453-64. 1999
    Clinically, high-dose treatment with the glucocorticosteroid, methylprednisolone (MP), within 8 h after spinal cord injury, has been shown to improve neurological recovery...
  80. ncbi High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes
    V I Leussink
    Department of Neurology, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Arch Neurol 58:91-7. 2001
    ..In the animal model experimental autoimmune encephalomyelitis, T-cell apoptosis can be induced by high-dose glucocorticoid (GC) administration...
  81. ncbi Effects of methylprednisolone infusion on markers of inflammation, coagulation, and angiogenesis in early acute respiratory distress syndrome
    Nitin Seam
    Pulmonary Section, Veterans Affairs Medical Center, Washington, DC, USA
    Crit Care Med 40:495-501. 2012
    Evaluate the effects of methylprednisolone on markers of inflammation, coagulation, and angiogenesis during early acute respiratory distress syndrome.
  82. ncbi Methylprednisolone fails to preserve retinal ganglion cells and visual function after ocular ischemia in rats
    Cornelia Dimitriu
    University Eye Hospital Freiburg, Freiburg, Germany
    Invest Ophthalmol Vis Sci 49:5003-7. 2008
    b>Methylprednisolone (MP) is commonly used to treat traumatic optic neuropathy and optic neuritis, but its benefit in terms of neuronal survival remains controversial...
  83. ncbi Combination therapy of cyclosporine and methylprednisolone on severe alopecia areata
    Beom Joon Kim
    Department of Dermatology, College of Medicine, Chung Ang University, Seoul, South Korea
    J Dermatolog Treat 19:216-20. 2008
    ..Although systemic cyclosporine appears to be one of the treatment options for chronic severe alopecia areata (AA), the high recurrence rates after discontinuation and side effects make cyclosporine a nominal agent for the treatment of AA...
  84. ncbi Effects of the neurokinin1 receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylprednisolone
    Jacqueline B McCrea
    Merck Research Laboratories, Bluebell, PA 19422, USA
    Clin Pharmacol Ther 74:17-24. 2003
    ..of cytochrome P4503A4 and may be used in conjunction with corticosteroids such as dexamethasone and methylprednisolone, which are substrates of cytochrome P4503A4...
  85. ncbi The effect of methylprednisolone on proliferation of PBMCs obtained from steroid-sensitive and steroid-resistant rheumatoid arthritis patients
    P Sliwinska-Stanczyk
    Department of Rheumatic Diseases, Institute of Rheumatology, Warsaw, Poland
    Scand J Rheumatol 36:167-71. 2007
    ..Unfortunately, up to 30% of patients with RA fail to respond to the treatment. We investigated the hypothesis that patients with RA who did not respond to GC treatment have steroid-resistant peripheral blood mononuclear cells (PBMCs)...
  86. ncbi Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial
    C Grootscholten
    Division of Nephrology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Kidney Int 70:732-42. 2006
    ..with oral prednisone (CY) or to azathioprine (2 mg/kg/day in 2 years) combined with intravenous pulses of methylprednisolone (3 x 3 pulses of 1000 mg) and oral prednisone (AZA). After a median follow-up of 5...
  87. pmc Comparative evaluation of megadose methylprednisolone with dexamethasone for treatment of primary typical optic neuritis
    Vimala Menon
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Indian J Ophthalmol 55:355-9. 2007
    To compare the efficacy of intravenous methylprednisolone and intravenous dexamethasone on visual recovery and evaluate their side-effects for the treatment of optic neuritis.
  88. ncbi Efficacy of multidrug therapy combined with mizoribine in children with diffuse IgA nephropathy in comparison with multidrug therapy without mizoribine and with methylprednisolone pulse therapy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima University School of Medicine, Fukushima, Japan
    Am J Nephrol 24:576-81. 2004
    ..with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).
  89. ncbi Dose-dense high-dose methylprednisolone and rituximab in the treatment of relapsed or refractory high-risk chronic lymphocytic leukemia
    Regina Pileckyte
    Department of Hematology, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania
    Leuk Lymphoma 52:1055-65. 2011
    This study evaluated the efficacy and safety of dose-dense high-dose methylprednisolone (HDMP) plus rituximab (Rtx) in patients with high-risk CLL...
  90. pmc Pulsed electromagnetic fields stimulation prevents steroid-induced osteonecrosis in rats
    Shuai Ding
    Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People s Republic of China
    BMC Musculoskelet Disord 12:215. 2011
    ..The purpose of the study was to investigate the effects of PEMF stimulation on the prevention of steroid-induced osteonecrosis in rats and explore the underlying mechanisms...
  91. ncbi Super-high-dose methylprednisolone does not improve efficacy or induce glucocorticoid resistance in experimental allergic encephalomyelitis
    Zhi sheng Wei
    Department of Neurology, First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, China
    Neuroimmunomodulation 18:28-36. 2011
    To investigate whether a super-high dose (SHD) of methylprednisolone (MP) improves its efficacy or induces glucocorticoid (GC) resistance, and to explore the potential mechanisms of GC resistance in experimental allergic encephalomyelitis ..
  92. ncbi Methylprednisolone inhibits the expression of glial fibrillary acidic protein and chondroitin sulfate proteoglycans in reactivated astrocytes
    Wei Lin Liu
    Graduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taipei, Taiwan
    Glia 56:1390-400. 2008
    ..b>Methylprednisolone (MP), a synthetic glucocorticoid, has been shown to have neuroprotective and anti-inflammatory effects for ..
  93. ncbi Methylprednisolone treatment delays remote cell death after focal brain lesion
    M T Viscomi
    Santa Lucia Foundation Istituto Ricovero e Cura Carattere Scientifico, Rome, Italy
    Neuroscience 154:1267-82. 2008
    ..Here we examine the effectiveness of a high dose (50 mg/kg) of methylprednisolone sodium succinate (MPSS) in reducing neuronal loss, glial response and glial-derived inflammatory mediators ..
  94. pmc Methylprednisolone for acute spinal cord injury: not a standard of care
    Herman Hugenholtz
    Division of Neurosurgery, Queen Elizabeth II Health Sciences Centre, Halifax, NS
    CMAJ 168:1145-6. 2003
  95. ncbi High dose methylprednisolone counteracts the negative effects of rocuronium on diaphragm function
    Karen Maes
    Respiratory Muscle Research Unit, Laboratory of Pneumology and Respiratory Division, Katholieke Universiteit Leuven, 3000, Leuven, Belgium
    Intensive Care Med 37:1865-72. 2011
    ..Based on clinical observations we examined whether the combination of rocuronium with corticosteroids during CMV would result into a further deterioration of diaphragm function...
  96. ncbi The role of intravenous methylprednisolone immunosuppression in the management of active thyroid eye disease
    Katya Tambe
    LID, Lacrimal and Orbit Service, Department of Ophthalmology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE1 5WW, UK
    Orbit 29:227-31. 2010
    To analyze the efficacy of intravenous methylprednisolone (IVMP) immunosuppression in the management of active thyroid eye disease (TED).
  97. ncbi In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammation
    R Inapagolla
    Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI 48202, USA
    Int J Pharm 399:140-7. 2010
    Dendrimers are an emerging class of nanoscale intracellular drug delivery vehicles. Methylprednisolone (MP) is an important corticosteroid used in the treatment (through inhalation) of lung inflammation associated with asthma...
  98. ncbi Clinical trial to compare efficacy and side-effects of injection of posterior sub-Tenon triamcinolone versus orbital floor methylprednisolone in the management of posterior uveitis
    Paolo Ferrante
    Moorfields Eye Hospital, London, UK
    Clin Experiment Ophthalmol 32:563-8. 2004
    ..To compare the efficacy and side-effects of posterior sub-Tenon injection of triamcinolone acetonide (Kenalog) with orbital floor injection of methylpredisolone acetate (Depomedrone) in the management of posterior uveitis...
  99. ncbi Reduction of relapses of atopic dermatitis with methylprednisolone aceponate cream twice weekly in addition to maintenance treatment with emollient: a multicentre, randomized, double-blind, controlled study
    A Peserico
    Department of Dermatology, University of Padua, Padua, Italy
    Br J Dermatol 158:801-7. 2008
    ..Efficacy and safety of corticosteroids have been proven in the acute treatment of active AD, but their long-term efficacy and potential to reduce or prevent relapses have only partially been addressed...
  100. ncbi Low-dose pulse methylprednisolone for systemic lupus erythematosus flares is efficacious and has a decreased risk of infectious complications
    H Badsha
    Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore
    Lupus 11:508-13. 2002
    We sought to test our clinical impression that using a low dose methylprednisolone pulse (MEP; < or = 1500 mg over 3 days) in treating flares of systemic lupus erythematosus (SLE) was effective and associated with fewer serious ..
  101. ncbi Why do you prescribe methylprednisolone for acute spinal cord injury? A Canadian perspective and a position statement
    R J Hurlbert
    Department of Clinical Neurosciences, Foothills Hospital and Medical Centre, Calgary, AB, Canada
    Can J Neurol Sci 29:236-9. 2002
    To determine the practice patterns for methylprednisolone administration for patients with acute spinal cord injury (SCI) within the spinal surgery community across Canada, and the reasons behind these patterns.

Research Grants63

  1. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..A positive control group will undergo high-volume MV plus therapy with IV methylprednisolone (30 mg/kg)...
  2. Therapeutic Value of Fish Oil Rx on SLE and Bone Loss in Mice
    GABRIEL J J FERNANDES; Fiscal Year: 2012
    ..is to determine the interaction of OMACOR n-3 fatty acids along with immunosuppressive cyclophosphamide and methylprednisolone drug therapy after the onset of SLE in controlling renal disease and bone loss in MRL/lpr mice...
  3. Mechanisms of diaphragm muscle dysfunction in critical-illness myopathy
    CATHERINE S SASSOON; Fiscal Year: 2012
    ..mechanical ventilation combined with both neuromuscular junction blocking agents (NMBA) and corticosteroid (methylprednisolone, MP). These patients have difficulty weaning from mechanical ventilation...
  4. Hormonal Intervention Protects Axon-myelin to Promote Functional Recovery in SCI
    Naren L Banik; Fiscal Year: 2013
    ..Since the only currently available treatment, methylprednisolone, has limited clinical efficacy, novel therapies to block inflammation, reduce cell and axon-myelin damage, ..
  5. Preoperative Therapy for Prevention of Postoperative Low Cardiac Output Syndrome
    D Woodrow Benson; Fiscal Year: 2010
    ..placebo-controlled clinical trial, to investigate whether preoperative administration of glucocorticoids (methylprednisolone, steroids) and/or erythropoietin (EPO) will afford protection from ischemia-reperfusion injury and thereby ..
  6. Mitochondrial-Targeted Therapeutics for Treatment of Spinal Cord Injury
    Patrick G Sullivan; Fiscal Year: 2013
    ..is a long-term health care problem in the United States, and with the exception of the modestly effective methylprednisolone, there is currently no neuroprotective intervention clinically available for treatment of acute SCI...
  7. IND 20212 (03-25-99) PHASE 2: ORBEC (ORAL BDP)-PATIENTS WITH CHRONIC GVHD
    CHRISTOPHER JOSEPH SCHABER; Fiscal Year: 2013
    ..of oral BDP offers a major therapeutic advantage over systemic glucocorticoids such as prednisone and methylprednisolone, which have well-recognized adverse effects (e.g...
  8. HANTAVIRUS ECOLOGY AND DISEASE IN CHILE AND PANAMA
    Gregory Mertz; Fiscal Year: 2009
    ..In Project 2, Treatment and Prevention of HCPS, we will complete a controlled trial of intravenous methylprednisolone in persons with suspected HCPS in the cardiopulmonary phase, continue collection of plasma by plasmapheresis ..
  9. Clinical corticosteroid therapy: Impact on oral mucosal wound healing
    CHRISTOPHER ENGELAND; Fiscal Year: 2009
    ..30 women) will receive either corticosteroid, in a single intravenous dose common in oral surgery (125 mg methylprednisolone), or placebo. Subjects will then have three small wounds placed on the oral hard palate by a periodontist...
  10. Novel Therapies for Chlorine-Induced Lung Injury
    Gary W Hoyle; Fiscal Year: 2013
    ..m.) injection, a preferred delivery route for potential mass casualty situations. In addition, methylprednisolone, an FDA-approved anti-inflammatory compound, will be evaluated as an alternative to triptolide...
  11. Ocular Disposition of Antimicrobial Agents
    Ashim K Mitra; Fiscal Year: 2010
    ..and in the presence of topically applied anti-inflammatory steroids (prednisolone, prednisone and 6-alpha-methylprednisolone)...
  12. OPTIC NEURITIS TREATMENT TRIAL--COORDINATING CENTER
    Patricia Cleary; Fiscal Year: 1991
    ..This study was also designed to compare oral prednisone therapy with high dose intravenous methylprednisolone. Based on a sample size estimate, 145 patients will be recruited for each of three treatment groups: placebo,..
  13. ROLE OF CYCLOSPORINE METABOLISM IN TRANSPLANTATION
    NEIL LEMPERT; Fiscal Year: 1990
    ..the relationship between CsA metabolism and nephrotoxicity in humans and rats; to determine the effect of methylprednisolone, azathioprine, and inhibitors and inducers of the cyt-P450 system on CsA metabolism and nephrotoxicity in ..
  14. IONIC BASIS OF ISCHEMIC CEREBRAL EDEMA
    Wise Young; Fiscal Year: 1992
    ..The effects of systemic furosemide, mannitol, and/or methylprednisolone on extracellular and tissue ionic shifts will be studied in the rat MCAo and cortical freeze models...
  15. PULSE THERAPY TRIAL IN BETA INTERFERON RESISTANT ACTIVE
    Derek Smith; Fiscal Year: 2003
    ..There is evidence that treatment of these patients with pulse methylprednisolone, pulse mitoxantrone or pulse cyclophosphamide may effectively reduce disease activity in these patients and ..
  16. MATERNAL-FETAL TRANSMISSION OF SIV IN MACAQUES
    Hans Ochs; Fiscal Year: 1992
    ..These studies will provide information that can not be obtained by observing HIV-infected women and their offspring...
  17. CLINICAL TRAILS IN PEDIATRIC RHEUMATOLOGY
    Daniel Lovell; Fiscal Year: 2004
    ..One therapy regimen is composed of intravenous methylprednisolone for 3 consecutive days, intravenous cyclophosphamide on the third day, and up to 20 mg/M2/wk of methotrexate...
  18. ONTT COOPERATING CLINIC
    Jonathan Trobe; Fiscal Year: 1991
    ..essentially two research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  19. ONTT COOPERATING CLINIC
    James Goodwin; Fiscal Year: 1991
    ..essentially two research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  20. ONTT COOPERATING CLINIC
    GEORGIA CHROUSOS; Fiscal Year: 1991
    ..consists of two research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  21. CORTICOSEROID PHARMACOKINETICS AND PHARMACODYNAMICS
    William Jusko; Fiscal Year: 2004
    ..The second aim is to generalize our "fourth-generation" receptor/gene PK/PD model for methylprednisolone to other steroids based on advanced QSAR principles and the expectation that alterations in pharmacokinetics ..
  22. Novel Restorative Therapy For Spinal Cord Injury
    Feng Qiao Li; Fiscal Year: 2006
    ..Currently, there is no cure for SCI, and methylprednisolone is the only choice on clinic, even without FDA approval...
  23. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..These changes will coincide with improved behavioral performance. To test the hypothesis that methylprednisolone potentiates the therapeutic effects of LIF and upregulates LIF transport, we will examine not only these ..
  24. Campath-1H & Calcineurin-Inhibitors in Renal Transplant
    Stuart Knechtle; Fiscal Year: 2007
    ..immunosuppression consisting of a calcineurin inhibitor, mycophenolate mofetil, and low-dose steroids (methylprednisolone 10 mg a day). We have witnessed approximately 5% incidence of rejection with very few side effects...
  25. OPTIC NEURITIS TREATMENT TRIAL COOPERATING CLINIC
    Edward Buckley; Fiscal Year: 1991
    ..essentially two research components; (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  26. ONTT COOPERATING CLINIC
    JOHN MC CRARY; Fiscal Year: 1991
    ..essentially two research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  27. OPTIC NURITIS TREATMENT TRIALS
    Barrett Katz; Fiscal Year: 1991
    ..consists of 2 research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  28. ONTT COOPERATING CLINIC
    David Kaufman; Fiscal Year: 1991
    ..essentially two research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  29. ONTT COOPERATING CLINIC
    PETER SAVINO; Fiscal Year: 1992
    ..essentially two research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patient with optic neuritis; and (2) a study of the natural ..
  30. ONTT COOPERATING CLINIC
    WILLIAM SHULTS; Fiscal Year: 1991
    ..essentially two research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  31. ONTT COOPERATING CLINIC
    Michael Brodsky; Fiscal Year: 1991
    ..essentially two research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residule optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  32. ONTT COOPERATING CLINIC
    Neil Miller; Fiscal Year: 1992
    ..essentially two research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  33. ONTT COOPERATING CLINIC
    Mark Kupersmith; Fiscal Year: 1991
    ..essentially two research components: (1) a clinical trial of the efficacy of oral pednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  34. SPINAL CORD INJURY, METHYLPREDNISOLONE & P GLYCOPROTEIN
    CHRISTOPHER BERNARDS; Fiscal Year: 2002
    ..therapy shown to reduce the severity of neurologic damage is massive intravenous doses of a glucocorticoid (methylprednisolone) administered during the first 3-48 hrs after injury...
  35. ONTT COOPERATING CLINIC
    H Thompson; Fiscal Year: 1991
    ..essentially two research components: (1) a clinical trial of the efficacy of oral prednisone and intravenous methylprednisolone in reducing residual optic nerve damage in patients with optic neuritis; and (2) a study of the natural ..
  36. METHYLPREDNISOLONE TREATMENT IN ACUTE SPINAL CORD INJURY
    Jan Xu; Fiscal Year: 2004
    DESCRIPTION: (Verbatim from the Applicant's Abstract) Methylprednisolone (MP), a synthetic glucocorticoid (GC), is the only proven therapeutic agent for acute spinal cord injury (SCI)...
  37. DHEA in re-establishing connectivity after SCI
    Nathalie Compagnone; Fiscal Year: 2003
    ..Current treatment of SCI is unsuccessful and relies only on use of methylprednisolone, which is controversial since its outcome on functional recovery is poor...
  38. OPTIMAL TREATMENT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS
    Richard Fine; Fiscal Year: 2007
    ..Aims of this proposal are to compare two regimens: (a) low-dose CS and sirolimus, and (b) intravenous methylprednisolone and cyclophosphamide in patients with SRFSGS who do not respond with a complete remission to a 16 week ..
  39. AEROSOL CYCLOSPORINE FOR PREVENTION OF LUNG REJECTION
    Aldo Iacono; Fiscal Year: 2001
    ..Acute rejection is treated with pulsed methylprednisolone and anti-lymphocyte globulin and consequently recipients are subject to increased risk of infection and drug ..
  40. Use of Clenbuterol for Enhancement of Stem Cell Therapy
    Richard Zeman; Fiscal Year: 2002
    ..At present, only methylprednisolone has been shown to have efficacy in humans for SCI However, the extent of recovery is limited so that ..
  41. DEVELOPMENT OF THERAPEUTICS FOR SPINAL CORD INJURY
    Richard Zeman; Fiscal Year: 2000
    ..At present, only methylprednisolone has been shown to have efficacy in humans for SCI...
  42. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2002
    ..Based on the results in Phase I we will continue working with methylprednisolone. We will test the system in a primate model, and develop human cells towards beginning Phase I clinical ..
  43. TRANSGENIC XENOTRANSPLANTS FOR HUNTINGTON'S DISEASE
    Ole Isacson; Fiscal Year: 2002
    ..xenografts survival in the primate brain requires immunosuppression by cyclosporine, azathiopirne, methylprednisolone and complement inhibition (CD59 transgenic donor tissue and monoclonal antibodies against complement C5)...
  44. Use of Tempol for Spinal Cord Injury
    Richard Zeman; Fiscal Year: 2004
    ..Presently, only methylprednisolone has been shown to have efficacy in humans for SCI. However, the extent of recovery is limited...
  45. ABSORPTION AND SECRETION IN DIARRHEAL DISEASES
    Mark Donowitz; Fiscal Year: 1980
    ..Na-K-ATPase in in vivo absorptive and secretory processes; 2) the mechanism by which the glucocorticoid methylprednisolone alters intestinal transport processes; 3) the mechanism by which serotonin stimulates intestinal secretion; ..
  46. Perinatal Risk of Asthma in Infants of Asthmatic Mothers
    Michael Bracken; Fiscal Year: 2007
    ..Identification of pregnancy and neonatal risk factors for infant asthma may offer opportunities for early prevention. ..
  47. Peroxynitrite-Induced Oxidative Damage in TBI
    Edward Hall; Fiscal Year: 2007
    ..abstract_text> ..
  48. 26th National Neurotrauma Symposium, 2008
    Edward Hall; Fiscal Year: 2008
    ..Particular efforts are made to actively engage students to participate and interact with leading basic and clinical scientists. [unreadable] [unreadable] [unreadable] [unreadable]..
  49. Paraxanthine and Reproductive Effects of Caffeine
    Michael Bracken; Fiscal Year: 2004
    ..abstract_text> ..
  50. Novel Neuroprotectants for TBI
    Edward Hall; Fiscal Year: 2008
    ..Thousands experience long lasting brain injury that interferes with their ability to lead productive and full lives. We plan to test a promising new class of therapeutics for traumatic brain injury. [unreadable] [unreadable] [unreadable]..
  51. Neuroprotection by a metalloporphyrin in spinal injury
    Danxia Liu; Fiscal Year: 2009
    ..b>Methylprednisolone (MP) is the only drug approved for SCI treatment;however side effects limit its utility...
  52. CELLULAR IMMUNOTHERAPY FOR HEMATOLOGIC MALIGNANCY
    John Levine; Fiscal Year: 2006
    ..2A. To evaluate a panel of cytokines as surrogate markers for GVHD and correlate these with clinical outcomes during the above trial. 2B. To correlate changes in minimal residual disease with clinical outcomes during the above trial. ..
  53. OXIDATION OF MACROMOLECULES IN SPINAL CORD INJURY
    Danxia Liu; Fiscal Year: 2001
    ..This will directly test whether free radicals damage neurons by inducing oxidation of major cell components and will provide strategies for therapy. ..
  54. Brain Atrophy/Diffusion Tensor Study/Multiple Sclerosis
    Robert Fox; Fiscal Year: 2008
    ..We hypothesize that the short-term decline in brain parenchymal fraction (BPF) following intravenous methylprednisolone predicts increased subsequent disease progression...
  55. Predictors of Skin Cancer in Commercial Airline Pilots
    Joyce Nicholas; Fiscal Year: 2005
    ..abstract_text> ..
  56. WT1 Expression in Patients with MDS Treated with ATG an*
    H Deeg; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  57. Cloning Kawasaki Disease-specific antigens
    Anne Rowley; Fiscal Year: 2005
    ..These plans will provide me with opportunities for enhanced career development by acquisition of new research skills, and will be fostered by the strong interdisciplinary research environment at Northwestern. ..
  58. Novel Clinical and Ocular Imaging Outcomes with Long-Term Follow-Up in MS
    Laura Balcer; Fiscal Year: 2010
    ..Aim 3: Determine how low-contrast letter acuity, RNFL thickness, and total macular volume impact vision specific and overall health-related quality of life (HRQOL) in longitudinal studies of MS and ON. ..
  59. Molecular Mechanisms Underlying Age-Related Hearing Loss
    Jianxin Bao; Fiscal Year: 2004
    ..The ultimate goal of this research is to develop methods for prevention and treatment of age-related loss of SGNs, based on identifying molecular candidates involved in this aging process. ..
  60. Sustained Release Inner Ear Delivery of Corticosteroid
    William Slattery; Fiscal Year: 2007
    ..This system could also be used for other drugs where chronic delivery is essential. [unreadable] [unreadable] [unreadable]..
  61. Pathophysiology and Characterisation of NAFLD
    Michael Charlton; Fiscal Year: 2009
    ..We believe that these experiments will generate mechanistic insight into the cause and effects of increased oxidative stress in patients with histologically progressive NAFLD. ..
  62. MINERALIZATION OF PRIMARY BONE
    JEFFREY GORSKI; Fiscal Year: 2008
    ..Results of this work should better define the differences between primariy and lamellar bone, as well as aid in the diagnosis and treatment of osteoporosis and atherosclerosis. ..
  63. Mycophenylate mofetil for treatment of chronic GVHD
    Paul Martin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..