prednisolone

Summary

Summary: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.

Top Publications

  1. ncbi Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100
    Juliet Richards
    Section of Medicine, The Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Cancer Res 72:2176-82. 2012
  2. ncbi Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial
    Björn Svensson
    University of Lund, Lund, Sweden
    Arthritis Rheum 52:3360-70. 2005
  3. ncbi Oral or IV prednisolone in the treatment of COPD exacerbations: a randomized, controlled, double-blind study
    Ynze P de Jong
    Department of Pulmonology, Isala Klinieken, Pulmonology, PO Box 10500, Zwolle 8000 GM, The Netherlands
    Chest 132:1741-7. 2007
  4. ncbi Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis
    Hisashi Oku
    Division of Frontier Drug Discovery, Discovery Research Laboratories, Shionogi and Co, Ltd, 2 5 1, Mishima, Settsu, Osaka 566 0022, Japan
    Eur J Pharmacol 590:400-8. 2008
  5. ncbi Prednisolone in Duchenne muscular dystrophy with imminent loss of ambulation
    Sunil Pradhan
    Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India
    J Neurol 253:1309-16. 2006
  6. pmc Why are Dutch rheumatologists reluctant to use the COBRA treatment strategy in early rheumatoid arthritis?
    Lilian H D van Tuyl
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, PO Box 7057, 1053 MB Amsterdam, The Netherlands
    Ann Rheum Dis 66:974-6. 2007
  7. ncbi Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial
    Tohru Kobayashi
    Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan
    Lancet 379:1613-20. 2012
  8. ncbi Very low-dose prednisolone in early rheumatoid arthritis retards radiographic progression over two years: a multicenter, double-blind, placebo-controlled trial
    Siegfried Wassenberg
    Evangelisches Fachkrankenhaus Ratingen, Ratingen, Germany
    Arthritis Rheum 52:3371-80. 2005
  9. ncbi Remission achieved after 2 years treatment with low-dose prednisolone in addition to disease-modifying anti-rheumatic drugs in early rheumatoid arthritis is associated with reduced joint destruction still present after 4 years: an open 2-year continuation
    I Hafstrom
    The Rheumatology Unit, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Ann Rheum Dis 68:508-13. 2009
  10. ncbi Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy
    Francis W Ballardie
    Department of Nephrology, Royal Infirmary and University, Manchester, United Kingdom
    J Am Soc Nephrol 13:142-8. 2002

Detail Information

Publications378 found, 100 shown here

  1. ncbi Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100
    Juliet Richards
    Section of Medicine, The Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Cancer Res 72:2176-82. 2012
    ..We found that prednisolone plasma levels in patients with CRPC were sufficiently high to activate mutant AR...
  2. ncbi Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial
    Björn Svensson
    University of Lund, Lund, Sweden
    Arthritis Rheum 52:3360-70. 2005
    To assess the efficacy of low-dose prednisolone on joint damage and disease activity in patients with early rheumatoid arthritis (RA).
  3. ncbi Oral or IV prednisolone in the treatment of COPD exacerbations: a randomized, controlled, double-blind study
    Ynze P de Jong
    Department of Pulmonology, Isala Klinieken, Pulmonology, PO Box 10500, Zwolle 8000 GM, The Netherlands
    Chest 132:1741-7. 2007
    ..We conducted a study to demonstrate that therapy with oral prednisolone was not inferior to therapy with IV prednisolone using a double-blind, double-dummy design.
  4. ncbi Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis
    Hisashi Oku
    Division of Frontier Drug Discovery, Discovery Research Laboratories, Shionogi and Co, Ltd, 2 5 1, Mishima, Settsu, Osaka 566 0022, Japan
    Eur J Pharmacol 590:400-8. 2008
    ..effect on various pulmonary cytokines, in bleomycin-induced lung fibrosis in mice at the protein level, using prednisolone as a reference agent...
  5. ncbi Prednisolone in Duchenne muscular dystrophy with imminent loss of ambulation
    Sunil Pradhan
    Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India
    J Neurol 253:1309-16. 2006
    An open controlled trial of 0.75 mg/Kg/day prednisolone was conducted at a stage when the patients had started falling several times in a day and stopped on their attaining a chair bound stage, thus minimising the total period of steroid ..
  6. pmc Why are Dutch rheumatologists reluctant to use the COBRA treatment strategy in early rheumatoid arthritis?
    Lilian H D van Tuyl
    Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, PO Box 7057, 1053 MB Amsterdam, The Netherlands
    Ann Rheum Dis 66:974-6. 2007
    The Combinatietherapie Bij Reumatoide Artritis (COBRA) trial has proved that combination therapy with prednisolone, methotrexate and sulphasalazine is superior to sulphasalazine monotherapy in suppressing disease activity and radiological ..
  7. ncbi Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial
    Tohru Kobayashi
    Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan
    Lancet 379:1613-20. 2012
    ..We assessed whether addition of prednisolone to intravenous immunoglobulin with aspirin would reduce the incidence of coronary artery abnormalities in ..
  8. ncbi Very low-dose prednisolone in early rheumatoid arthritis retards radiographic progression over two years: a multicenter, double-blind, placebo-controlled trial
    Siegfried Wassenberg
    Evangelisches Fachkrankenhaus Ratingen, Ratingen, Germany
    Arthritis Rheum 52:3371-80. 2005
    To assess the effect of 5 mg/day prednisolone on disease progression in patients with early rheumatoid arthritis (RA) receiving standardized disease-modifying antirheumatic drug (DMARD) therapy.
  9. ncbi Remission achieved after 2 years treatment with low-dose prednisolone in addition to disease-modifying anti-rheumatic drugs in early rheumatoid arthritis is associated with reduced joint destruction still present after 4 years: an open 2-year continuation
    I Hafstrom
    The Rheumatology Unit, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Ann Rheum Dis 68:508-13. 2009
    To evaluate if remission induced by low-dose prednisolone during the first 2 years of rheumatoid arthritis (RA) in the BARFOT glucocorticoid (GC) study had a sustained effect on radiological damage for a total of 4 years.
  10. ncbi Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy
    Francis W Ballardie
    Department of Nephrology, Royal Infirmary and University, Manchester, United Kingdom
    J Am Soc Nephrol 13:142-8. 2002
    ..38 patients with progressive IgA nephropathy and controlled hypertension were randomized to treatment with prednisolone and cytotoxic agents, to therapy with low-dose cyclophosphamide then azathioprine, and to control groups...
  11. ncbi Long-term outcomes of idiopathic membranous nephropathy in Japanese patients treated with low-dose cyclophosphamide and prednisolone
    Masahiro Eriguchi
    Kidney Center, Matsuyama Red Cross Hospital, Matsuyama, Japan
    Nephrol Dial Transplant 24:3082-8. 2009
    ..We studied the long-term outcomes of low-dose cyclophosphamide and prednisolone therapy in Japanese patients, who were thought to have relatively benign IMN compared with Caucasian patients.
  12. ncbi A case of toxic epidermal necrolysis with diverse etiologies: successful treatment with intravenous immunoglobulin and pulse prednisolone and effects on sTRAIL and sCD200 levels
    Arzu Didem Yalcin
    Department of Internal Medicine, Allergy and Clinical Immunology Unit, Antalya Training and Research Hospital, Antalya, Turkey
    Clin Lab 59:681-5. 2013
    ..SCORTEN is a scoring system used to predict mortality in TEN patients. If SCORTEN index is 5 or more, mortality rate is more than 90%. SCORTEN of our patient was calculated as 5...
  13. ncbi Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis
    Masoud Soheilian
    Department of Ophthalmology and Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti Medical University, Tehran, Iran
    Ophthalmology 118:134-41. 2011
    ..To compare the efficacy of intravitreal injection of clindamycin and dexamethasone with classic treatment for ocular toxoplasmosis...
  14. ncbi A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy
    Vivekanand Jha
    Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012 India
    J Am Soc Nephrol 18:1899-904. 2007
    ..This study compared the effect of a 6-mo course of alternating prednisolone and cyclophosphamide with supportive treatment in adults with nephrotic syndrome caused by IMN on doubling of ..
  15. ncbi The role of prednisolone and epinephrine on gastric tissue and erythrocyte antioxidant status in adrenalectomized rats
    A Yildirim
    Department of Biochemistry, Ataturk University, Medical Faculty, Erzurum, Turkey
    J Physiol Pharmacol 58:105-16. 2007
    ..As well, the impacts of administration of prednisolone and epinephrine on these systems in adrenalectomized rats were investigated...
  16. ncbi Induction and long-term treatment with cyclosporine in membranous nephropathy with the nephrotic syndrome
    Efstathios Alexopoulos
    Department of Nephrology, Hippokration General Hospital, 49, Konstantinoupoleos str, 54642 Thessaloniki, Greece
    Nephrol Dial Transplant 21:3127-32. 2006
    ..However, the optimal dose and the duration of treatment remain controversial issues. We evaluated the efficacy of low-dose CyA alone or combined with corticosteroids as induction and long-term treatment for nephrotic patients with MN...
  17. pmc A phase two randomised controlled double blind trial of high dose intravenous methylprednisolone and oral prednisolone versus intravenous normal saline and oral prednisolone in individuals with leprosy type 1 reactions and/or nerve function impairment
    Stephen L Walker
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS Negl Trop Dis 5:e1041. 2011
    ..attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.
  18. ncbi Docetaxel plus prednisolone for the treatment of metastatic hormone-refractory prostate cancer: a multicenter Phase II trial in Japan
    S Naito
    Department of Urology, Faculty of Medicine, Kyushu University 71, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8585, Japan
    Jpn J Clin Oncol 38:365-72. 2008
    ..This study was undertaken to assess the feasibility of docetaxel in combination with prednisolone in Japanese patients with HRPC.
  19. ncbi No difference between prednisolone and dexamethasone treatment in bone mineral density and growth in long term survivors of childhood acute lymphoblastic leukemia
    Robert D van Beek
    Department of Pediatric Hematology Oncology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 46:88-93. 2006
    ..known to have both more potent leukemic activity and is associated with a higher incidence of side effects than prednisolone. In this study, we compared the long-term effects of dexamethasone and prednisolone on bone mineral density (..
  20. ncbi Leprosy type 1 (reversal) reactions and their management
    Stephen L Walker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK
    Lepr Rev 79:372-86. 2008
    ..One randomised controlled trial showed that patients treated with a 5 month course of prednisolone (total dose 2...
  21. pmc Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells
    Esther Hulleman
    Department of Pediatric Oncology and Hematology, Erasmus Medical Center Sophia Children s Hospital, University Medical Center, Rotterdam, The Netherlands
    Blood 113:2014-21. 2009
    ..in pediatric acute lymphoblastic leukemia (ALL) is related to cellular resistance to glucocorticoids (eg, prednisolone)...
  22. ncbi Comparison of nebulized budesonide and oral prednisolone with placebo in the treatment of acute exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial
    Francois Maltais
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, 2275 Chemin Ste Foy, Ste Foy, Quebec G1V 4G5, Canada
    Am J Respir Crit Care Med 165:698-703. 2002
    ..randomized, placebo-controlled trial, the efficacy of nebulized budesonide (Pulmicort Respules/Nebuamp), oral prednisolone, and placebo was compared in 199 patients with acute exacerbations of COPD requiring hospitalization...
  23. ncbi Treatment of chronic rhinosinusitis with nasal polyposis with oral steroids followed by topical steroids: a randomized trial
    Sriram Vaidyanathan
    Ninewells Hospital, University of Dundee, United Kingdom
    Ann Intern Med 154:293-302. 2011
    ..Chronic rhinosinusitis (CRS) with nasal polyposis is common. The long-term efficacy and safety of approaches to medical management are not well-known...
  24. ncbi Acute and 2-week exposure to prednisolone impair different aspects of beta-cell function in healthy men
    Daniel H van Raalte
    Endocrinology Section, Department of Internal Medicine, Diabetes Centre, VU University Medical Centre, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Endocrinol 162:729-35. 2010
    Glucocorticoids (GCs), such as prednisolone, are associated with adverse metabolic effects, including glucose intolerance and diabetes...
  25. ncbi Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial
    Thomas F Hiemstra
    University of Cambridge and Lupus and Vasculitis Unit, Addenbrookes Hospital, Cambridge, England
    JAMA 304:2381-8. 2010
    ..Current remission maintenance therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are limited by partial efficacy and toxicity...
  26. ncbi Glucocorticosteroids increase cell entry by hepatitis C virus
    Sandra Ciesek
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany
    Gastroenterology 138:1875-84. 2010
    ..However, these drugs worsen hepatitis C virus (HCV) recurrence after liver transplantation, suggesting that they may directly exacerbate HCV infection...
  27. pmc Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor
    Raoul Frijters
    Computational Drug Discovery CDD, Nijmegen Centre for Molecular Life Sciences NCMLS, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 26 28, Nijmegen, The Netherlands
    BMC Genomics 11:359. 2010
    ..To study the importance of GR dimerization in the regulation of gene expression, we performed gene expression profiling of livers of prednisolone-treated wild type (WT) and mice that have lost the ability to form GR dimers (GRdim).
  28. ncbi Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma
    Heinz Ludwig
    Department of Medicine I, Wilhelminenspital Vienna, Vienna, Austria
    Blood 113:3435-42. 2009
    We compared thalidomide-dexamethasone (TD) with melphalan-prednisolone (MP) in 289 elderly patients with multiple myeloma (MM)...
  29. pmc Lack of radiological and clinical benefit over two years of low dose prednisolone for rheumatoid arthritis: results of a randomised controlled trial
    H A Capell
    Centre for Rheumatic Diseases, Glasgow Royal Infirmary, North Glasgow University NHS Trust, Castle St, Glasgow G40SF, UK
    Ann Rheum Dis 63:797-803. 2004
    ..Evidence for disease modifying activity of low dose corticosteroid treatment in rheumatoid arthritis is contradictory. Studies showing radiological benefit suggest that continued treatment is required to sustain the effect...
  30. ncbi Effects of low-dose prednisolone on endothelial function, atherosclerosis, and traditional risk factors for atherosclerosis in patients with rheumatoid arthritis--a randomized study
    Ingiäld Hafström
    Department of Rheumatology, Department of Cardiology, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Rheumatol 34:1810-6. 2007
    To determine the influence of low-dose prednisolone on atherosclerosis, endothelial function, and risk factors for atherosclerosis in patients with early rheumatoid arthritis (RA).
  31. ncbi Prednisolone suppresses the function and promotes apoptosis of plasmacytoid dendritic cells
    P P C Boor
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Am J Transplant 6:2332-41. 2006
    ..Purified PDC were cultured with or without clinically relevant concentrations of cyclosporin, tacrolimus or prednisolone. Apoptosis induction was monitored by determination of active caspase-3, nuclear condensation and annexin-V/..
  32. ncbi Clinical efficacy of a short course of systemic steroids in nasal polyposis
    Virat Kirtsreesakul
    Department of Otolaryngology, Faculty of Medicine, Prince of Songklu University, Thailand
    Rhinology 49:525-32. 2011
    ..The aim of this study was to evaluate the efficacy of a short course of oral prednisolone in nasal polyposis and to evaluate which, if any, clinical variables can predict treatment outcome in these ..
  33. ncbi Long-term outcome of patients with diffuse proliferative lupus nephritis treated with prednisolone and oral cyclophosphamide followed by azathioprine
    T M Chan
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Lupus 14:265-72. 2005
    ..significant proteinuria, and hypoalbuminemia, who had been treated with sequential immunosuppression comprising prednisolone and oral cyclophosphamide as induction followed by low-dose prednisolone and azathioprine as maintenance...
  34. ncbi Prednisolone suppression test in depression: prospective study of the role of HPA axis dysfunction in treatment resistance
    Mario F Juruena
    Section of Neurobiology of Mood Disorders, PO 74, Institute of Psychiatry, 103 Denmark Hill, London SE5 8AF, UK
    Br J Psychiatry 194:342-9. 2009
    ..People with severe depressive illness have raised levels of cortisol and reduced glucocorticoid receptor function...
  35. ncbi Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis
    E H S Choy
    Sir Alfred Baring Garrod Clinical Trials Unit, Academic Department of Rheumatology, King s College School of Medicine, Weston Education Centre, Cutcombe Road, London SE5 9RJ, UK
    Ann Rheum Dis 67:656-63. 2008
    ..As the relative benefits of combining two DMARDs, one DMARD with glucocorticoids and two DMARDs with glucocorticoids are uncertain we defined them in a factorial trial...
  36. ncbi Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure
    Andrew Spencer
    Malignant Haematology and Stem Cell Transplantation Service, Alfred Hospital, Melbourne, Victoria, Australia
    J Clin Oncol 27:1788-93. 2009
    ..This study assessed whether the addition of thalidomide consolidation following ASCT would improve the durability of responses achieved and overall survival...
  37. pmc Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial
    D H van Raalte
    Diabetes Centre, Department of Internal Medicine, VU University Medical Centre, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Diabetologia 54:2103-12. 2011
    ..To assess whether low-dose glucocorticoid treatment induces adverse metabolic effects, as is evident for high glucocorticoid doses...
  38. ncbi Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone
    Philippe Mathurin
    Sce d Hépato Gastroentérologie, Hôpital Claude Hurriez, and Inserm EPI 0114 Lille, Paris, France
    Hepatology 38:1363-9. 2003
    ..In conclusion, ECBL is a very simple predictive factor for identifying nonresponders. A recommendation to discontinue corticosteroids after 7 days in patients without ECBL, suggested by our results, awaits additional confirmation...
  39. ncbi Treatment of eosinophilic meningitis with a combination of prednisolone and mebendazole
    Verajit Chotmongkol
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Am J Trop Med Hyg 74:1122-4. 2006
    To study the efficacy of the combination of prednisolone and mebendazole for the treatment of eosinophilic meningitis, we conducted a pilot study among Thai patients with eosinophilic meningitis...
  40. ncbi The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1
    Clara Di Filippo
    The William Harvey Research Institute, Queen Mary School of Medicine and Dentistry, University of London, Charterhouse Square, EC1M 6BQ London, UK
    J Pharmacol Exp Ther 310:1133-41. 2004
    Daily administration of prednisolone, but not the derivative NCX-1015 (or prednisolone 21-[4'-nitrooxymethyl]benzoate), to rats resulted in a time- and dose-dependent increase in mean arterial blood pressure (MABP), significant after 1 ..
  41. ncbi Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone
    Sakchai Wittaya-Areekul
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand
    Int J Pharm 312:113-8. 2006
    This study describes the preparation of mucoadhesive alginate/chitosan microparticles containing prednisolone intended for colon-specific delivery...
  42. pmc Short course prednisolone for adhesive capsulitis (frozen shoulder or stiff painful shoulder): a randomised, double blind, placebo controlled trial
    R Buchbinder
    Monash Department of Clinical Epidemiology, Cabrini Hospital, Melbourne, Australia
    Ann Rheum Dis 63:1460-9. 2004
    To determine whether a short course of prednisolone is superior to placebo for improving pain, function, and range of motion in adhesive capsulitis.
  43. ncbi Increasing the dose of prednisolone during viral infections reduces the risk of relapse in nephrotic syndrome: a randomised controlled trial
    A S Abeyagunawardena
    Department of Paediatrics, University of Peradeniya, Peradeniya, Sri Lanka
    Arch Dis Child 93:226-8. 2008
    ..Relapses of nephrotic syndrome are often triggered by viral upper respiratory tract infections (URTIs), possibly mediated by cytokine release...
  44. ncbi Efficacy of prednisolone in children hospitalized for recurrent wheezing
    Tuomas Jartti
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Allergy Immunol 18:326-34. 2007
    ..To determine whether prednisolone is effective in rhinovirus- or enterovirus-induced recurrent wheezing, we conducted a controlled trial ..
  45. ncbi Prednisolone suppresses NK cell cytotoxicity in vitro in women with a history of infertility and elevated NK cell cytotoxicity
    Meen Yau Thum
    Lister Fertility Clinic, Lister Hospital, London, UK
    Am J Reprod Immunol 59:259-65. 2008
    To evaluate the effect of prednisolone on NK cell cytotoxicity in vitro environment and also to compare the effect of prednisolone versus immunoglobulin-G (IVIG) on NK cell cytotoxicity using in vitro co-culture with K562 cells.
  46. ncbi Long-term follow-up of patients with IgA nephropathy treated with prednisolone and cyclophosphamide therapy
    Satoshi Oshima
    Self Defense Force Central Hospital, 1 2 24 Ikejiri, Setagaya Ku, Tokyo, Japan
    Clin Exp Nephrol 12:264-9. 2008
    ..We also examined the relationship between the efficacy of the treatment and the suppression of the serum immunoglobulin level...
  47. ncbi Corticosteroids for treating nerve damage in leprosy. A Cochrane review
    Natasja H J Van Veen
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Lepr Rev 79:361-71. 2008
    ..Corticosteroids are commonly used for treating nerve damage in leprosy. We assessed the effectiveness of corticosteroids for treating nerve damage due to leprosy...
  48. pmc Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation
    Patrick Paulus
    Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
    PLoS ONE 8:e73298. 2013
    ..To investigate these effects we performed orthotopic lung transplantations (LTX) in the rat. Prednisolone was either added to the perfusion solution for lung preservation or omitted and rats were followed for 48 hours ..
  49. ncbi Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery
    Marcus Ang
    Singapore National Eye Centre, Singapore
    Curr Eye Res 36:1123-8. 2011
    To evaluate the effect of a biodegradable microfilm with sustained release of prednisolone acetate (PA) on postoperative wound healing after experimental glaucoma filtration surgery (GFS).
  50. ncbi Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritis
    L A Joosten
    Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    Inflamm Res 48:48-55. 1999
    ..To investigate potential synergy of low dosages glucocorticosteroids (GC's) and interleukin-10 (IL-10), using established murine collagen-induced arthritis (CIA) as a model...
  51. ncbi Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction
    Debby den Uyl
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 64:639-46. 2012
    ..To investigate the dose-related effects of glucocorticoid treatment on glucose tolerance, beta cell function, and insulin sensitivity in patients with early active rheumatoid arthritis (RA)...
  52. ncbi Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: a 2 × 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis
    Bongani M Mayosi
    The Cardiac Clinic, Department of Medicine, Groote Schuur Hospital, Cape Town, South Africa
    Am Heart J 165:109-15.e3. 2013
    ..w) can safely reduce mortality and morbidity...
  53. ncbi Pulsed high-dose dexamethasone versus standard prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy (PREDICT study): a double-blind, randomised, controlled trial
    Ivo N van Schaik
    Department of Neurology, Academic Medical Center, University of Amsterdam, Netherlands
    Lancet Neurol 9:245-53. 2010
    ..The PREDICT study aimed to compare remission rates in patients with CIDP treated with high-dose dexamethasone with rates in patients treated with standard oral prednisolone.
  54. ncbi Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus
    Yu Kajiyama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:159-65. 2010
    Glucocorticoids are known to cause psychiatric disorders including depression. Prednisolone (PSL) is one of the most widely used synthetic glucocorticoids to treat various medical diseases; however, little is known about PSL-induced ..
  55. ncbi Long-term remission of CIDP after pulsed dexamethasone or short-term prednisolone treatment
    F Eftimov
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Neurology 78:1079-84. 2012
    ..In this prospective cohort study we present long-term follow-up data on patients included in a multicenter randomized controlled trial comparing 6 monthly pulses of dexamethasone with 8 months of daily prednisolone.
  56. ncbi Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells
    Margot M L Linssen
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cell Signal 23:1708-15. 2011
    Glucocorticoids (GCs), such as prednisolone (PRED), are widely prescribed anti-inflammatory drugs, but their use may induce glucose intolerance and diabetes...
  57. ncbi A feasibility trial of screening women with idiopathic recurrent miscarriage for high uterine natural killer cell density and randomizing to prednisolone or placebo when pregnant
    Ai Wei Tang
    Department for Women s and Children s Health, Institute of Translational Medicine, University of Liverpool, Liverpool L8 7SS, UK
    Hum Reprod 28:1743-52. 2013
    Is it feasible to screen women with idiopathic recurrent miscarriage (RM) for high uterine natural killer (uNK) cell density and then randomize them to prednisolone or placebo when pregnant?
  58. ncbi Cyclosporine decreases skin lesions and pruritus in dogs with atopic dermatitis: a blinded randomized prednisolone-controlled trial
    Thierry Olivry
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Vet Dermatol 13:77-87. 2002
    ..with nonseasonal AD were randomly allocated to receive an oral solution of either NEORAL CsA (5 mg kg-1) or prednisolone (0.5 mg kg-1) once daily for 6 weeks...
  59. ncbi Steroid responsive meningitis-arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006-2008)
    M Lowrie
    Division of Companion Animal Sciences, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
    J Vet Intern Med 23:862-70. 2009
    Previous multidrug studies have identified the value of prednisolone in treating steroid responsive meningitis-arteritis (SRMA) and the potential value of acute phase proteins (APPs) and immunoglobulin A (IgA) in diagnosis and monitoring.
  60. ncbi Randomized open comparative trial of dexamethasone-cyclophosphamide pulse and daily oral cyclophosphamide versus cyclophosphamide pulse and daily oral prednisolone in pemphigus vulgaris
    Pradeep K Sethy
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi 110 029, India
    Indian J Dermatol Venereol Leprol 75:476-82. 2009
    ..In various case series, pulse therapy has shown good results in pemphigus vulgaris (PV), with long-term remissions...
  61. ncbi Optimum prednisolone usage in patients with biliary atresia postportoenterostomy
    Hiroyuki Kobayashi
    Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Pediatr Surg 40:327-30. 2005
    b>Prednisolone is used routinely after portoenterostomy (PE) in patients with biliary atresia (BA). The authors reviewed their patients with BA post-PE to assess prednisolone protocols.
  62. pmc Long-term clinical, immunologic and virologic impact of glucocorticoids on the chronic phase of HIV infection
    Jean Marie Andrieu
    Institut de Recherche sur les Vaccins et l Immunothérapie des cancers et du SIDA, Laboratoire d Oncologie et Virologie Moléculaire, Centre Biomédical des Saints Pères, Universite Rene Descartes, Paris, France
    BMC Med 2:17. 2004
    ..immune system activation/destruction process associated with chronic HIV infection, we focused our interest on prednisolone (PDN), because we had showed that, in vitro, PDN had a strong anti-apoptotic activity on activated T cells of ..
  63. ncbi Evaluating patients' outcome post-Kasai operation: a 19-year experience with modification of the hepatic portoenterostomy and applying a novel steroid therapy regimen
    Tatsuya Suzuki
    Division of Pediatric Surgery and Transplant Surgery, Nagoya City University Hospital, Mizuho ku, Nagoya, Aichi, Japan
    Pediatr Surg Int 26:825-30. 2010
    ..HPE is associated with a risk of hepatic impairment, so we adopted a novel steroid therapy regimen well suited to our procedure. This paper reports the results of our experience...
  64. ncbi Continuous monitoring of circadian glycemic patterns in patients receiving prednisolone for COPD
    Morton G Burt
    Southern Adelaide Diabetes and Endocrine Services, Repatriation General Hospital, Daw Park, Adelaide 5041, Australia
    J Clin Endocrinol Metab 96:1789-96. 2011
    Endogenous glucocorticoid excess (Cushing's syndrome) predominantly increases postprandial glucose concentration. The pattern of hyperglycemia induced by prednisolone has not been well characterized.
  65. ncbi BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia
    Nan Jiang
    Department of Paediatrics, Division of Haematology and Oncology, Yong Loo Lin School of Medicine, National University Hospital, National University of Singapore, 5 Lower Kent Ridge Road, Singapore
    Exp Hematol 39:321-9, 329.e1-3. 2011
    Glucocorticoids such as prednisolone (PRED) are widely used in the treatment of pediatric acute lymphoblastic leukemia. In PRED-induced apoptosis, Bcl-2 family members play important regulatory roles...
  66. ncbi Granulocyteaphaeresis in steroid-dependent inflammatory bowel disease: a prospective, open, pilot study
    E Domenech
    Hospital Universitari Germans Trias i Pujol, Badalona, Spain
    Aliment Pharmacol Ther 20:1347-52. 2004
    ..Uncontrolled studies suggest that granulocyteaphaeresis might be useful in the management of active ulcerative colitis...
  67. ncbi Prednisolone treatment affects the performance of the QuantiFERON gold in-tube test and the tuberculin skin test in patients with autoimmune disorders screened for latent tuberculosis infection
    Erika Bélard
    Department of Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark
    Inflamm Bowel Dis 17:2340-9. 2011
    ..The objective was to evaluate the performance of the QuantiFERON Gold In-Tube (QFT-IT) and the Tuberculin Skin Test (TST)...
  68. ncbi Docetaxel in combination with prednisolone for hormone refractory prostate cancer
    Hiroki Ide
    Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Jpn J Clin Oncol 40:79-84. 2010
    The objective of this study was to evaluate the efficacy and toxicity of docetaxel in combination with prednisolone in Japanese patients with hormone refractory prostate cancer.
  69. ncbi Clinical features and outcomes of eosinophilic myocarditis patients treated with prednisolone at a single institution over a 27-year period
    Sayaka Kawano
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Japan
    Intern Med 50:975-81. 2011
    ..The prognosis of patients with eosinophilic myocarditis is difficult to determine due the disease's rarity and varied causes; consequently, standard treatment has not been established...
  70. ncbi Anemia and erythropoiesis-stimulating agent administration in patients with non-Hodgkin lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone ± rituximab chemotherapy: results from an observational study
    Corinne Haioun
    Hematology Department, Henri Mondor Hospital, Creteil, France
    Leuk Lymphoma 52:796-803. 2011
    CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone) ± rituximab [(± R)CHOP] is the current standard of care for aggressive non-Hodgkin lymphoma (NHL)...
  71. ncbi Paediatric acute asthma management in Australia and New Zealand: practice patterns in the context of clinical practice guidelines
    F E Babl
    Emergency Department, Royal Children s Hospital, Parkville, VIC 3052, Australia
    Arch Dis Child 93:307-12. 2008
    ..All 11 sites participate in the Paediatric Research in Emergency Departments International Collaborative (PREDICT) research network...
  72. ncbi Prednisolone-induced changes in gene-expression profiles in healthy volunteers
    Erik J M Toonen
    MSD Research Laboratories, Oss, The Netherlands
    Pharmacogenomics 12:985-98. 2011
    b>Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident...
  73. ncbi A palatability study of a flavored dexamethasone preparation versus prednisolone liquid in children
    Heather Hames
    Department of Medicine, University of Western Ontario, London, Canada
    Can J Clin Pharmacol 15:e95-8. 2008
    ..Palatability is an important factor in medication compliance for children where the acceptability of a liquid medication and its ease of administration will be greatly affected by its taste...
  74. ncbi IL-1beta genotype-related effect of prednisolone on IL-1beta production in human peripheral blood mononuclear cells under acute inflammation
    Svetlana Markova
    Division of Clinical Pharmacokinetics, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Biol Pharm Bull 30:1481-7. 2007
    Glucocorticoids such as prednisolone are used for their anti-inflammatory properties...
  75. ncbi Comparison of colchicine versus prednisolone in recurrent aphthous stomatitis: A double-blind randomized clinical trial
    Atessa Pakfetrat
    Oral Medicine Department, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
    Clin Invest Med 33:E189-95. 2010
    ..In this study, we compared the therapeutic effects of 5 mg/d prednisolone with 0.5 mg/d colchicine in the treatment of RAS.
  76. ncbi MRI evaluation of the antitumor activity of paramagnetic liposomes loaded with prednisolone phosphate
    Evelina Cittadino
    Department of Chemistry, IFM and Molecular and Preclinical Imaging Centres, University of Torino, Via Nizza 52, I 10126, Torino, Italy
    Eur J Pharm Sci 45:436-41. 2012
    The design of long circulating liposomes co-loaded with the glucocorticoid prednisolone phosphate (PLP) and the amphiphilic paramagnetic contrast agent Gd-DOTAMA(C(18))(2) allowed the MRI-guided in vivo visualization of the delivery and ..
  77. ncbi Long-term outcome of autoimmune pancreatitis after oral prednisolone therapy
    Takayoshi Nishino
    Institute of Gastroenterology, Department of Medicine, Tokyo Women s Medical University, School of Medicine
    Intern Med 45:497-501. 2006
    ..the long-term outcome of autoimmune pancreatitis (AIP) including morphological changes in the pancreas, pancreatic duct, biliary tract, pancreatic function, and changes in the clinical manifestations after oral prednisolone (PSL) therapy.
  78. ncbi Low-dose prednisolone has a CD4-stabilizing effect in pre-treated HIV-patients during structured therapy interruptions (STI)
    A Ulmer
    HIV Schwerpunktpraxis, Stuttgart, Germany
    Eur J Med Res 10:227-32. 2005
    ..of CD4+ T cells was firstly noticed in therapy-naive HIV-patients without antiretroviral therapy (ART) taking 5 mg prednisolone daily. This observation led to the prescription of prednisolone during structured therapy interruptions (STI).
  79. ncbi Idiopathic immune-mediated hemolytic anemia: treatment outcome and prognostic factors in 149 dogs
    C J Piek
    Department of Clinical Sciences of Companion Animals, Utrecht University, Utrecht, The Netherlands
    J Vet Intern Med 22:366-73. 2008
    ..Canine idiopathic immune-mediated hemolytic anemia (IMHA) is associated with a high mortality, especially in the 1st 2 weeks after diagnosis despite treatment...
  80. ncbi Prednisolone inhibits hyperosmolarity-induced expression of MCP-1 via NF-kappaB in peritoneal mesothelial cells
    H Matsuo
    The Second Department of Internal Medicine, University of Occupational and Environmental Health School of Medicine, and Kidney Center, University Hospital, Kitakyushu, Japan
    Kidney Int 69:736-46. 2006
    ..Mannitol caused a similar increase in PKC and NF-kappaB activation and MCP-1 synthesis. Prednisolone increased I-kappaB-alpha expression and inhibited glucose/mannitol-induced NF-kappaB DNA binding and MCP-1 ..
  81. ncbi A randomized, double-blind, placebo-controlled trial of the use of prednisolone as an adjunct to treatment in HIV-1-associated pleural tuberculosis
    Alison M Elliott
    Uganda Virus Research Institute, Entebbe
    J Infect Dis 190:869-78. 2004
    ..We examined the effect that prednisolone has on survival in HIV-1-associated pleural tuberculosis.
  82. ncbi Site-specific targeting of nanoparticle prednisolone reduces in-stent restenosis in a rabbit model of established atheroma
    Michael Joner
    Deutsches Herzzentrum Muenchen und Medizinische Klinik, Klinikum rechts der Isar, Muenchen, Germany
    Arterioscler Thromb Vasc Biol 28:1960-6. 2008
    TRM-484 is a novel drug consisting of nanoparticles of prednisolone with high affinity to chondroitin sulfate proteoglycans (CSPGs)...
  83. ncbi Placebo-controlled oral pulse prednisolone therapy in alopecia areata
    Bikash Ranjan Kar
    Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Am Acad Dermatol 52:287-90. 2005
    ..None of the studies published so far regarding their use in AA have been randomized or placebo-controlled...
  84. ncbi Prednisolone treatment induces tolerogenic dendritic cells and a regulatory milieu in myasthenia gravis patients
    Claudia Luther
    Department of General Neurology and Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Tubingen University Hospital, Germany
    J Immunol 183:841-8. 2009
    ..Interestingly, Treg cells from prednisolone-treated myasthenia gravis patients showed an improved suppressive function compared with untreated patients, ..
  85. ncbi Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells
    Wim J E Tissing
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Blood 109:3929-35. 2007
    ..Affymetrix U133A GeneChips were used to identify transcriptionally regulated genes on 3 and 8 hours of prednisolone exposure in leukemic cells of 13 children as compared with nonexposed cells...
  86. ncbi Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes
    Josbert M Metselaar
    Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
    Arthritis Rheum 48:2059-66. 2003
    ....
  87. ncbi Retardation of joint damage in patients with early rheumatoid arthritis by initial aggressive treatment with disease-modifying antirheumatic drugs: five-year experience from the FIN-RACo study
    Markku Korpela
    Tampere University Hospital, Tampere, Finland
    Arthritis Rheum 50:2072-81. 2004
    ....
  88. ncbi Prednisolone therapy in Duchenne muscular dystrophy prolongs ambulation and prevents scoliosis
    O Yilmaz
    Hacettepe University School of Physiotherapy, Ankara, Turkey
    Eur J Neurol 11:541-4. 2004
    ..Treatment regimen was oral prednisolone 0.75 mg/kg on alternate days, plus vitamin D 600-1200 units/day and a calcium-enriched diet...
  89. ncbi Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients
    Rogier R Press
    Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands
    Ther Drug Monit 31:187-97. 2009
    ..analysis was performed to estimate the effects of demographic factors, hematocrit, serum albumin concentration, prednisolone dose, TRL dose interval, polymorphisms in genes coding for ABCB1, CYP3A5, CYP3A4, and the pregnane X receptor ..
  90. ncbi Practicability and acute haematological toxicity of 2- and 3-weekly CHOP and CHOEP chemotherapy for aggressive non-Hodgkin's lymphoma: results from the NHL-B trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)
    A Wunderlich
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
    Ann Oncol 14:881-93. 2003
    ..To enable more extensive testing of these schemes we here characterise their practicability regarding schedule adherence, acute haematotoxicity and need for supportive treatment...
  91. ncbi Low dose prednisolone reduces CD4+ T cell loss in therapy-naive HIV-patients without antiretroviral therapy
    Albrecht Ulmer
    HIV Schwerpunktpraxis, Schwabstr 26, D 70197 Stuttgart, Germany
    Eur J Med Res 10:105-9. 2005
    ..of CD4+ T cells was noticed in therapy-naive HIV-patients without antiretroviral therapy (ART) taking 5 mg prednisolone daily...
  92. ncbi Efficacy and safety of tacrolimus (FK506) in treatment of rheumatoid arthritis: a randomized, double blind, placebo controlled dose-finding study
    Hirobumi Kondo
    Japanese Tacrolimus FK506 RA Study Group, Kitasato University School of Medicine, Kanagawa, Japan
    J Rheumatol 31:243-51. 2004
    ..To evaluate the efficacy and safety of tacrolimus (FK506) in patients with active rheumatoid arthritis (RA) exhibiting resistance to disease modifying antirheumatic drug (DMARD) therapy, and to determine the optimal dosage...
  93. ncbi Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: a comparison of their glucocorticoid and mineralocorticoid properties
    Claudia Grossmann
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur J Endocrinol 151:397-406. 2004
    ....
  94. ncbi Methimazole-induced lupus erythematosus: a case report
    Li Chieh Wang
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC
    J Microbiol Immunol Infect 36:278-81. 2003
    ..Methimazole was discontinued, and she was treated with prednisolone and Plaquenil, after which the symptoms and laboratory tests became normal within 40 days...
  95. ncbi Acute severe steatohepatitis related to prednisolone therapy
    S P Dourakis
    Am J Gastroenterol 97:1074-5. 2002
  96. pmc Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Thorax 57:847-52. 2002
    ..The aim of this study was to investigate whether these are related...
  97. pmc Effects of prednisolone treatment on cytokine expression in patients with leprosy type 1 reactions
    Anna K Andersson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E HTM, United Kingdom
    Infect Immun 73:3725-33. 2005
    ..The anti-inflammatory drug prednisolone is used for treatment, but there is little good in vivo data on the molecular actions of prednisolone...
  98. ncbi Prednisolone maintenance dose in relation to starting dose in the treatment of polymyalgia rheumatica and temporal arteritis. A prospective two-year study in 273 patients
    G Myklebust
    Department of Rheumatology, Institute of Clinical Medicine, University of Tromsø, Norway
    Scand J Rheumatol 30:260-7. 2001
    ..To describe the maintenance dose and annual cessation rate of oral corticosteroids in relation to the starting dose in patients with polymyalgia rheumatica (PMR) and temporal arteritis (TA)...
  99. ncbi Randomized, double-blind, placebo-controlled trial of prednisolone in post-infectious irritable bowel syndrome
    S P Dunlop
    Division of Gastroenterology, University Hospital, Nottingham, UK
    Aliment Pharmacol Ther 18:77-84. 2003
    ..Animal studies have suggested that steroids reduce the lymphocyte response and suppress some of the post-infectious changes in neuromuscular function...
  100. ncbi Prednisolone and valaciclovir in Bell's palsy: a randomised, double-blind, placebo-controlled, multicentre trial
    Mats Engstrom
    Department of Otorhinolaryngology and Head and Neck Surgery, Uppsala University Hospital, Uppsala, Sweden
    Lancet Neurol 7:993-1000. 2008
    ..The aim of this study was to compare the short-term and long-term effects of prednisolone and valaciclovir in the recovery of the affected facial nerve in a large number of patients.
  101. ncbi Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemia
    M L den Boer
    Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, PO Box 2060, 3000 CB Rotterdam, The Netherlands
    J Clin Oncol 21:3262-8. 2003
    To confirm the prognostic value of a drug resistance profile combining prednisolone, vincristine, and l-asparaginase (PVA) cytotoxicity in an independent group of children with acute lymphoblastic leukemia (ALL) treated with a different ..

Research Grants62

  1. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..study has shown that hearing loss in the MRL/MpJ-Faslpr autoimmune mouse responds to both the glucocorticoid prednisolone and the mineralocorticoid aldosterone...
  2. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    ..of this new grant application are: (1) to determine transscleral permeability of steroids (dexamethasone and prednisolone) and anti-VEGF monoclonal antibody (bevacizumab) (i) alone (ii) encapsulated in unmodified and surface modified ..
  3. Proteomics Biomarkers Development Laboratory
    Samir Hanash; Fiscal Year: 2009
    ..abstract_text> ..
  4. Relation of Consummatory and Anticipatory Food Reward to Obesity
    Sonja Yokum; Fiscal Year: 2013
    ..An improved understanding of the neural substrates that contribute to obesity should inform the development of more effective prevention and treatment interventions for this pernicious medical condition. ..
  5. Novel Biomarkers and Causal Pathways in RA Susceptbility
    Karen H Costenbader; Fiscal Year: 2013
    ....
  6. Mechanisms and Treatment of Chronic, Latent Human Strongyloidiasis
    James B Lok; Fiscal Year: 2013
    ..be tested under Aim 1 of the R21 phase of the project by ascertaining whether common medicinal steroids such as prednisolone or its common metabolites can activate Ss-DAF-12 signaling in a cell based reporter assay...
  7. Chemical Biodiversity: Investigating the Phylogeny and Functional Toxins of Venom
    MANDE N HOLFORD; Fiscal Year: 2010
    ..A thorough mentoring plan will address development needs as they refer to the PIs scientific achievement, training of students and postdoctoral fellows, and independent career advancement. ..
  8. Genetics of Parkinsonism in a Special Population of Untreated Schizophrenia
    Gabriel Alejandro De Erausquin; Fiscal Year: 2013
    ..Lastly, we anticipate that our research strategy may indicate new waysto study and address the increased vulnerability of schizophrenic patients to nicotine dependence. ..
  9. Development of Novel Class of Anti-Inflammatory Drugs
    KEN CARTER; Fiscal Year: 2013
    ..and (3) compare the oral administration efficacy of 3 lead compounds against the parent compound 61610 and prednisolone, a steroid used by IBD patients, in mouse models of IBD...
  10. fMRI and Cognition in Adolescent Cannabis Users
    Susan F Tapert; Fiscal Year: 2010
    ..All analyses will control for premorbid factors (i.e., family history of substance use disorders and personality), educational involvement (i.e., attendance), and other substance use (i.e., alcohol, nicotine, and other drugs). ..
  11. Immunity in alcoholic hepatitis.
    Zhang Xu Liu; Fiscal Year: 2013
    ..Lymphocyte proliferation assay on day1 will be performed to predict the response to steroids. The effects of prednisolone+mycophenolate and prednisolone+rilonacept (anti-IL-1) treatment on the longitudinal changes of immunological ..
  12. Long-Acting Mucus-Penetrating Steroid Particles for Treatment of Eye Inflammation
    Hongming Chen; Fiscal Year: 2011
    ..In SBIR Phase I, we will build upon these findings to develop a sustained release MPP formulation of prednisolone acetate (PA), the most prescribed ophthalmic corticosteroid...
  13. A prospective, randomized, clinical trial to evaluate two novel therapies, mycoph
    TIMOTHY ROSS MORGAN; Fiscal Year: 2013
    ..Inflammation is the underlying cause of liver injury and the cause of symptoms and death. Prednisolone, the most commonly recommend treatment, improves survival in most, but not all, patients...
  14. CLINICAL TRIALS NETWORK: PACIFIC NORTHWEST NODE
    John M Roll; Fiscal Year: 2013
    ....
  15. Unbiased Approaches to Novel Biomarker Discovery in Parkinson's Disease
    Alice S Chen-Plotkin; Fiscal Year: 2013
    ....
  16. Comprehensive autopsy characterization of sudden cardiac death
    Zian H Tseng; Fiscal Year: 2013
    ..These data may elucidate a more accurate definition of SCD, new independent risk factors for arrhythmic SD in diverse populations, and lay the groundwork for future genetic and molecular studies. ..
  17. Southern California Alcoholic Hepatitis Consortium Administrative Core
    TIMOTHY ROSS MORGAN; Fiscal Year: 2013
    ..The pathophysiology of alcoholic hepatitis is incompletely understood and prednisolone, the recommended treatment for severe alcoholic hepatitis, is ineffective in a significant proportion of ..
  18. Ultrasonic Techniques for Bladder Compliance Measurement
    Mostafa Fatemi; Fiscal Year: 2013
    ..This information can potentially lead to earlier detection and improved management of bladder dysfunction. Thus, successful completion of this project may have a significant impact in diagnosis and management of bladder dysfunction. ..
  19. Imaging Research on Impulsivity, Stress and Drug Abuse
    Lynn M Oswald; Fiscal Year: 2012
    ..abstract_text> ..
  20. Developmental fMRI Study of Alcohol Use in Adolescence
    John VanMeter; Fiscal Year: 2013
    ....
  21. Pathogenesis of Vaccinia virus keratitis
    Curtis R Brandt; Fiscal Year: 2013
    ..In all groups that received prednisolone, keratitis rebounded within 3-4 days of halting the treatment and this was concomitant with the resumption of ..
  22. Adult consequences of youth substance use: Twin study enriched for SUD risk
    William G Iacono; Fiscal Year: 2013
    ..1 ..
  23. Ocular Disposition of Antimicrobial Agents
    Ashim K Mitra; Fiscal Year: 2010
    ..cultures (rPCEC), alone, in combination and in the presence of topically applied anti-inflammatory steroids (prednisolone, prednisone and 6-alpha-methylprednisolone)...
  24. Mechanisms of Immune Modulation in JIA
    NORA SINGER; Fiscal Year: 2013
    ..TREAT will test whether aggressive early therapy with ETN, prednisolone and MTX will induce an inactive disease (ID) state in patients with poly-JIA more frequently than conventional ..
  25. In Vivo Imaging of Leukocyte-Endothelial Dynamics
    William Mathers; Fiscal Year: 2005
    ..Aim three, we will determine the effect of medications including topical prednisolone acetate, a mast cell stabilizer (optipranolol), or an oral nonsteroidal anti-inflammatory drug (indomethacin) ..
  26. Matrix-induced Myogenesis & Pharmaco-Screens of MSCs
    Dennis Discher; Fiscal Year: 2009
    ..b>Prednisolone) and ultimately screen an NIH library for drug candidates that steer matrix-coupled myogenesis of stem cells...
  27. IMPROVED STEROID THERAPY FOR HEARING LOSS
    Dennis Trune; Fiscal Year: 2000
    ..The specific aims of the proposed study are to: Aim 1: To compare the effectiveness of prednisolone and aldosterone in reversing hearing loss once it occurs...
  28. Cognitive dysfunction and impaired inhibitory control in cocaine dependence
    Charles W Bradberry; Fiscal Year: 2013
    ..Understanding the source and mechanisms of cognitive dysfunction that predicts treatment outcome may help develop therapeutic approaches that lessen harm from addiction. ..
  29. Biomakers in Sickle Cell Anemia: Response to Hydroxyurea
    Marie Stuart; Fiscal Year: 2004
    ..In addition, findings from this study could have significant implications for other disease states associated with vasculopathy. ..
  30. ABNORMAL SODIUM HOMEOSTASIS IN HYPERTENSIVE PREGNANCY
    Steven Graves; Fiscal Year: 1992
    ....
  31. DEVELOPMENT SUBSEQUENT TO JAUNDICE OF THE NEWBORN
    JEAN JEW; Fiscal Year: 1980
    ..be used to evaluate and compare the effectiveness of various treatments (including phototherapy, albumin, and prednisolone administration) in ameliorating behavioral and biostructural abnormalities that occur in the homozygous Gunn ..
  32. CORTICOSEROID PHARMACOKINETICS AND PHARMACODYNAMICS
    William Jusko; Fiscal Year: 2004
    ..improved methods for assessing drug interactions for indirect response processes with focus on joint effects of prednisolone and COX-2 inhibitors...
  33. BLOOD PRESSURE, COGNITIVE FUNCTION & MRI IN OLDER ADULTS
    Iris Goldstein; Fiscal Year: 2001
    ..abstract_text> ..
  34. Cordyceps Sinensis Evaluation in IgA Nephropathy Model
    Abdalla Rifai; Fiscal Year: 2005
    ..injury and (iii) comparing CSE effects with known anti-inflammatory and immunosuppressive NF-KappaB modulators (Prednisolone and Cyclosporine-A). 2...
  35. Gordon Research Conference: Muscle: Contractile Proteins
    David Warshaw; Fiscal Year: 2002
    ..The discussions will be led by the Session Chair and a Session Poster Chair who will together be responsible for incorporating the poster participants into the discussion. ..
  36. NGF SIGNALING IN MODELS OF AGE RELATED NEURODEGENERATION
    William Mobley; Fiscal Year: 2002
    ..Evidence that abnormal NGF signaling is responsible for BFCN degeneration in models of AD and DS will give important new insights into pathogenesis and may suggest novel approaches to prevent or reverse dementia in these patients. ..
  37. NEUROTOXICITY OF CNS PROPHYLACTIC THERAPIES IN ALL
    PHYLLIS MULLENIX; Fiscal Year: 1993
    ..animals are exposed to various CNS prophylactic treatments involving cranial irradiation, methotrexate, and prednisolone. The relative neurotoxicity of these agents alone or in combination will be distinguished...
  38. OPIATES, IMMUNE FUNCTION, AND CONTROL OF HIV INFECTION
    Rob Roy MacGregor; Fiscal Year: 1991
    ..Finally, patients will be given a battery of psychological tests to define their degrees of psychopathology. These results will be correlated with the progressive state of the subjects' CMI, utilizing multivariate analysis...
  39. Neuroimaging Markers of Vulnerability to Depression
    Ronald Dahl; Fiscal Year: 2004
    ....
  40. GORDON CONFERENCE--MUSCLE CONTRACTILE PROTEINS
    Sarah Hitchcock DeGregori; Fiscal Year: 1999
    ..In the ninth, and last, session prominent participants will summarize sections of the conference in relation to where the field has been and may go in the next millennium. ..
  41. IGF-I LEVELS, IGF-I GENOTYPE, AND PROSTATE CANCER
    Noel Weiss; Fiscal Year: 2002
    ..abstract_text> ..
  42. Acoustic startle reduction in cocaine dependence
    Erica Duncan; Fiscal Year: 2009
    ..abstract_text> ..
  43. Phase II Chemoprevention Trial of Selenium and Prostate Cancer
    Frederick Ahmann; Fiscal Year: 2006
    ..abstract_text> ..
  44. HIPPOCAMPAL DAMAGE AS A CAUSE OF EPILEPSY
    PHILIP SCHWARTZKROIN; Fiscal Year: 1992
    ..Such information could provide a foundation for assessing the need for, and designing, interventive treatments in the clinical population suffering from lesion producing trauma and/or seizures...
  45. Otitis Media Impact on the Inner Ear
    Dennis Trune; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  46. The Role of Osteocyte Survival in Bone Strength
    Robert Weinstein; Fiscal Year: 2005
    ..The proposed research plan will reveal the role of osteocyte survival in bone strength and how osteocytes achieve this objective. ..
  47. Fluid Movement across Conjunctiva: Stimulation and Regulation
    OSCAR CANDIA; Fiscal Year: 2007
    ..These studies may provide the groundwork for the design of future treatment modalities for dry-eye syndromes. ..
  48. Measurement of Fluid Flow Across the Ocular Ciliary Body
    OSCAR CANDIA; Fiscal Year: 2006
    ..abstract_text> ..
  49. Transporter maintenance of dopamine homeostasis
    CLARE WILHELM; Fiscal Year: 2005
    ....
  50. Angiogenic Agents and Alveolar Injury
    Vineet Bhandari; Fiscal Year: 2007
    ..Determine the differences and the degree to which the response to hyperoxia-induced acute lung injury differs in adult, newborn and fetal mice with regard to VEGF, Angiopoietin 1 and Angiopoietin 2. ..
  51. SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVA
    OSCAR CANDIA; Fiscal Year: 2002
    ..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
  52. AN EVOLUTIONARY LINK BETWEEN TELOMERES AND TRANSPOSONS
    MARY LOU PARDUE; Fiscal Year: 2008
    ..We have discovered that HeT-A and TART expression can be regulated by several external agents. We describe experiments to better define the set of agents capable of this regulation and to explore possible mechanisms. ..
  53. ALCOHOL AND STRESS IN ADOLESCENCE
    Linda Spear; Fiscal Year: 2003
    ..The results of this basic research should provide an essential initial base of data regarding ethanol reinforcement and stress during adolescence as well as potential long-lasting consequences of such exposure. ..
  54. Computational Methods for Functional Genomics
    Simon Tavare; Fiscal Year: 2005
    ..This research program is specifically structured to provide practical and continuing training in this process. ..
  55. Biomarkers of oxidative stress and inflammation in COPD
    William MacNee; Fiscal Year: 2005
    ..Such information will allow the identification of novel biomarkers and the fingerprints themselves may represent a mechanism to stratify COPD patients and allow the assessment of novel therapies. ..
  56. An in Vivo Neurogenesis Assay to Discover Antidepressants and Cognitive Enhancers
    Mahalakshmi Shankaran; Fiscal Year: 2008
    ..We will use a powerful new method for measuring the production of new brain cells as a way to discover new drugs, and we will then test the effectiveness of these drugs on depression and memory. [unreadable] [unreadable] [unreadable]..
  57. Bronx-Lebanon Hospital Center Pediatric ACTU
    Murli Purswani; Fiscal Year: 2006
    ..abstract_text> ..
  58. Transgenic analysis of Smad tumor suppressor genes
    Stuart Newfeld; Fiscal Year: 2006
    ..This knowledge can be used to determine if Smad proteins should be exploited as anti-cancer drug discovery targets. ..
  59. Determinants of arterial function in hypertension
    Iftikhar J Kullo; Fiscal Year: 2010
    ..The aim of our investigation is to identify novel proteins and genes that influence arterial function. Such work will help in identifying those at risk of developing arterial disease and facilitate development of new therapies. ..
  60. Cytoskeletal Regulation of Outer Hair Cell Motility
    Federico Kalinec; Fiscal Year: 2007
    ..abstract_text> ..
  61. Young Investigators Initiative Workshop (U13)
    Nancy Lane; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..