Summary: A synthetic pregnadiene derivative with anti-aldosterone activity.
Publications101 found, 100 shown here
- Difference in metabolic profile of potassium canrenoate and spironolactone in the rat: mutagenic metabolites unique to potassium canrenoateC S Cook
Division of Product Safety Assessment, G D Searle and Co, Skokie, IL 60077
Arch Toxicol 61:201-12. 1988..Absence of the CAN epoxide pathway in the metabolism of SP provides a possible explanation for the observed differences in the toxicological profiles of the two compounds...
- Genotoxicity testing of potassium canrenoate in cultured rat and human cellsA Martelli
Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, I 16132 Genoa, Italy
Mutagenesis 14:463-72. 1999....
- Involvement of cytochrome P-450IIIA in metabolism of potassium canrenoate to an epoxide: mechanism of inhibition of the epoxide formation by spironolactone and its sulfur-containing metaboliteC S Cook
Department of Drug Metabolism, G D Searle and Co, Skokie, Illinois
J Pharmacol Exp Ther 266:1-7. 1993..Inhibition of PC metabolism to 6 beta, 7 beta-epoxy-CAN by TAO and erythromycin, and its induction by DEX and PCN, suggest involvement of Cyt P-450IIIA, which is in turn inhibited by SP and 7 alpha-thio-spirolactone...
- DNA damage in tissues of rat treated with potassium canrenoateAntonietta Martelli
Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Tossicologia Clinica, Viale Benedetto XV 2, I 16132, Genoa, Italy
Toxicology 171:95-103. 2002..A high and dose-dependent frequency of DNA lesions was found to occur in testes and ovaries of rats given single doses ranging from 1/8 to 1/2 LD50...
- Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosteroneMonica Minnaard-Huiban
Department of Pharmacology and Toxicology, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
Endocrinology 149:28-31. 2008....
- Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channelsRicardo Gomez
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
Br J Pharmacol 146:146-61. 2005..Blockade of these cardiac K(+) currents, together with the antagonism of the aldosterone proarrhythmic effects produced by SP, might be highly desirable for the treatment of supraventricular arrhythmias...
- Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosisMorag Young
Endocrine Genetics, Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
Endocrinology 144:3848-51. 2003....
- A new turbidometric digoxin immunoassay on the ADVIA 1650 analyzer is free from interference by spironolactone, potassium canrenoate, and their common metabolite canrenonePradip Datta
Bayer Diagnostics, Tarrytown, New York, USA
Ther Drug Monit 25:478-82. 2003..We conclude that the new turbidometric assay for digoxin is free from interference by spironolactone, potassium canrenoate, and their common metabolite canrenone...
- Efficacy and safety of the stepped care medical treatment of ascites in liver cirrhosis: a randomized controlled clinical trial comparing two diets with different sodium contentM Bernardi
Cattedra di Patologia Speciale Medica I, University of Bologna, Italy
Liver 13:156-62. 1993..Multivariate analysis showed that creatinine clearance and plasma aldosterone were independent predictive factors of the response to treatment.(ABSTRACT TRUNCATED AT 250 WORDS)..
- ACE-inhibition plus mineralocorticoid antagonism versus ACE-inhibition alone in patients with anterior myocardial infarctionP Di Pasquale
Division of Cardiology Paolo Borsellino, G F Ingrassia Hospital, Palermo, Italy
Cardiovasc Drugs Ther 15:309-14. 2001..Aldosterone antagonism in combination with ACE inhibition may better protect against untoward effects of aldosterone than ACE inhibition alone...
- Randomized clinical study of the efficacy of amiloride and potassium canrenoate in nonazotemic cirrhotic patients with ascitesP Angeli
Department of Clinical Medicine, University of Padua, Italy
Hepatology 19:72-9. 1994..abstract truncated at 250 words)..
- Time-course reduction of renal function in rats on high sodium intake: acute reversal by potassium canrenoateCaroline Rugale
Groupe Rein et Hypertension, Montpellier University, Montpellier, France
Clin Exp Pharmacol Physiol 35:412-5. 2008..The beneficial effect of acute administration of potassium canrenoate favours the participation of aldosterone, at least partially, in the sustained deterioration of renal function after 21 weeks of high sodium feeding...
- Collecting duct is a site of sodium retention in PAN nephrosis: a rationale for amiloride therapyG Deschenes
Service de Nephrologie Pediatrique, Hôpital Armand Trousseau Assistance Publique Hôpitaux de Paris, Paris, France
J Am Soc Nephrol 12:598-601. 2001....
- Elevated resting and exercise-induced cortisol levels after mineralocorticoid receptor blockade with canrenoate in healthy humansPeter Wellhoener
Department of Internal Medicine I, University Hospital Schleswig Holstein, D 23538 Luebeck, Germany
J Clin Endocrinol Metab 89:5048-52. 2004..The undiminished concentration of ACTH in the presence of elevated cortisol levels suggests that blockade of MR shifts the set point for cortisol feedback inhibition of the HPA axis toward higher cortisol levels...
- Steroidogenesis vs. steroid uptake in the heart: do corticosteroids mediate effects via cardiac mineralocorticoid receptors?Wenxia Chai
Division of Pharmacology, Erasmus Medical Center, Rotterdam, The Netherlands
J Hypertens 28:1044-53. 2010..To test whether glucocorticoids act as the endogenous agonist of cardiac mineralocorticoid receptors, we evaluated the cardiac effects of aldosterone and corticosterone and cardiac steroidogenesis vs. steroid uptake from plasma...
- Effects of canrenoate potassium, an aldosterone antagonist on portal hemodynamics in patients with compensated liver cirrhosisM Koda
Department of Clinical Laboratory Medicine, Tottori University, Faculty of Medicine, Japan
Hepatogastroenterology 43:887-92. 1996..We examined the effects of acute administration of canrenoate potassium, an aldosterone antagonist, on portal hemodynamics in compensated cirrhotic patients using noninvasive ..
- Effect of spironolactone and its metabolites on contractile property of isolated rat aorta ringsR Sorrentino
Department of Experimental Pharmacology, Naples, Italy
J Cardiovasc Pharmacol 36:230-5. 2000..Because both phenylephrine- and KCl-induced contractions imply an intracellular Ca2+ influx, we suggest that these drugs could act through an inhibition of voltage-dependent Ca2+ channels...
- Effect of intravenously applied canrenoate on ampullar endolymphatic potentialK Yura
Department of Otolaryngology, Kagawa Medical School, Japan
Acta Otolaryngol 115:648-52. 1995..Pretreatment with aldosterone attenuated the AEP change produced by canrenoate. The results suggest that aldosterone may be involved in the modulation of ampullar function...
- Suppression of surgical hyperaldosteronism by potassium canrenoate during gynecologic surgery under sevoflurane anesthesiaT Watanabe
Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
Acta Anaesthesiol Scand 44:758-62. 2000..This study investigated the effect of potassium canrenoate (PC) on pituitary adrenocortical function in lower abdominal surgery under sevoflurane anesthesia...
- Inhibition of catecholamine-induced cardiac fibrosis by an aldosterone antagonistRomain Bos
Service de Pharmacologie, CHU Pitie Salpetriere, Paris, France
J Cardiovasc Pharmacol 45:8-13. 2005..These results suggest a transregulation between the adrenergic and mineralocorticoid pathways, most likely at the nucleus level, with activation of profibrotic genes...
- Cardiac corticosteroid receptors mediate the enlargement of the ovine fetal heart induced by chronic increases in maternal cortisolSeth A Reini
Department of Pharmacodynamics, College of Pharmacy, University of Florida, Box 100487, Gainesville, Florida 32610 0487, USA
J Endocrinol 198:419-27. 2008....
- Mechanism of ursodeoxycholic acid- and canrenoate-induced biliary bicarbonate secretion and the effect on glucose- and amino acid-induced cholestasisE Omland
Dept of Surgery B, National Hospital Rikshospitalet, University of Oslo, Norway
Scand J Gastroenterol 26:513-22. 1991..The effect of UDCA or canrenoate on bile secretion is not disturbed by glucose or amino acids. Both substances stimulate canalicular bicarbonate secretion and could be of importance in improving cholestatic conditions...
- Extrarenal role of aldosterone in the regulation of blood pressureM Yamakado
Department of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan
Am J Hypertens 1:276-9. 1988To assess the hypothesis that aldosterone may have direct vasoconstrictive action, the acute effects of canrenoate potassium (Soldactone, S), an aldosterone antagonist, on hemodynamics and hormonal responses were determined before and ..
- Effects of a low-sodium diet on electrolyte transport in the proximal and distal colon of the guinea pig (Cavia porcellus)G Rechkemmer
Department of Physiology, School of Veterinary Medicine, Bischofsholer Damm, Hannover, Federal Republic of Germany
Comp Biochem Physiol Comp Physiol 103:501-5. 1992..In the distal colon Na absorption was abolished by luminal amiloride and the transepithelial PD was reversed in polarity. 7. K-canrenoate treatment prevented the increase in Na transport in the distal colon...
- Population pharmacokinetic model of canrenone after intravenous administration of potassium canrenoate to paediatric patientsMaysa Suyagh
Clinical and Practice Research Group, School of Pharmacy, Queen s University Belfast, 97 Lisburn Road, Belfast, UK
Br J Clin Pharmacol 74:864-72. 2012..Little is known about the pharmacokinetics of potassium canrenoate/canrenone in paediatric patients..
- Activation of the mineralocorticoid receptor increases striatin levelsLuminita H Pojoga
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Hypertens 25:243-9. 2012..Striatin, a membrane associated protein, interacts with estrogen receptors in endothelial cells...
- [Diuretic therapy in heart failure]G Splendiani
Dipartimento di Nefrologia e Dialisi, Policlinico Tor Vergata, Rome
G Ital Nefrol 23:S74-6. 2006..sodium channel inhibitors: amiloride and triamterene; b) aldosterone receptor antagonists: spironolactone, canrenoate potassium, eplerenone; 6) ADH antagonists: lithium salts, demeclocycline and ethanol...
- Differential effects of mineralocorticoid blockade on the hypothalamo-pituitary-adrenal axis in pregnant and nonpregnant ewesMelissa Lingis
Dept of Pharmacodynamics, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
Am J Physiol Endocrinol Metab 300:E592-9. 2011....
- Aldosterone influences free intracellular calcium in human mononuclear leukocytes in vitroM Wehling
Medizinische Klinik, University of Munich, FRG
Cell Calcium 11:565-71. 1990..These results show that aldosterone exerts an effect on the [Ca2+]i in HML in vitro which could be involved in hemodynamic responses to mineralocorticoids if also present in cardiovascular tissues...
- Reversible pharmacokinetic profiles of canrenoic acid and its biotransformed product. Canrenone in the ratS Asada
Kobe Women s College of Pharmacy, Japan
Chem Pharm Bull (Tokyo) 38:1012-8. 1990..Simultaneous computer multi-line fitting of plasma concentration-time data was carried out and the adequacy of pharmacokinetic parameters in this model was tested using the iterative nonlinear least-squares regression program, MULTI...
- Effect of spironolactone, potassium canrenoate and their common metabolite canrenone on serum digoxin measurement by digoxin III, a new digoxin immunoassayAmitava Dasgupta
Department of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas 77030, USA
Ther Drug Monit 30:744-7. 2008..We conclude that spironolactone, potassium canrenoate, and their common metabolite canrenone interfere with the serum digoxin measurements using the new Digoxin III assay...
- Combined versus sequential diuretic treatment of ascites in non-azotaemic patients with cirrhosis: results of an open randomised clinical trialP Angeli
Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, Padova, Italy
Gut 59:98-104. 2010..The aim of the study was to compare sequential versus combined diuretic therapy in patients with cirrhosis, moderate ascites and without renal failure...
- Effect of acute and prolonged mineralocorticoid receptor blockade on spontaneous and stimulated hypothalamic-pituitary-adrenal axis in humansRita Berardelli
Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Ospedale S Giovanni Battista Molinette, C so Dogliotti 14, Turin, Italy
Eur J Endocrinol 162:1067-74. 2010..Our study was performed in order to clarify this point...
- Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the ratRomain Bos
Service de Pharmacologie, CHU Pitie Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
J Pharmacol Exp Ther 309:1160-6. 2004..Potassium canrenoate attenuated the fibrosis but not the enhanced dilatation of the left ventricle induced by isoprenaline...
- Clinically insignificant negative interferences of spironolactone, potassium canrenoate, and their common metabolite canrenone in new dimension vista LOCI digoxin immunoassayAmitava Dasgupta
Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, TX 77030, USA
J Clin Lab Anal 26:143-7. 2012..However, such small bias may not have any clinical significance. We conclude that new Dimension Vista LOCI digoxin assay is virtually free from interferences of spironolactone, potassium canrenoate, and their common metabolite canrenone...
- Effect of the steroid K-canrenoate on hsp70 expression and tissue damage in transgenic Drosophila melanogaster (hsp70-lacZ) Bg9Yasir Hasan Siddique
Drosophila Transgenics Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U P, 202002, India
J Insect Sci 12:92. 2012..The results of the present study suggest that the K-canrenoate at 0.8 and 1.0 µL/mL is cytotoxic and caused tissue damage in the third instar larvae of transgenic D. melanogaster (hsp70-lacZ) Bg(9)...
- Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cellsPeter Riis Hansen
Department of Cardiology P, Gentofte University Hospital, DK 2900 Hellerup, Denmark
Immunol Lett 91:87-91. 2004..Overexpression of proinflammatory cytokines contribute to the development and progression of CHF...
- Comparative evaluation of digoxin concentrations determined by three assay systems: TDx, IMx and OPUSYoshiyuki Kagawa
Department of Hospital Pharmacy, Mie University School of Medicine, Edobashi 2 174, Tsu City, Mie 514 8507, Japan
Biopharm Drug Dispos 25:21-6. 2004..These results suggest that OPUS has a higher specificity for measuring the plasma digoxin concentrations compared with TDx or IMx...
- Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine modelAtsushi Sugiyama
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
J Pharmacol Sci 96:436-43. 2004....
- Effects of the aldosterone receptor antagonist potassium canrenoate on renal blood flow and urinary output during prolonged increased intraabdominal pressure (IAP) in pigsF F Gudmundsson
Surgical Research Laboratory, Department of Surgical Sciences, University of Bergen, 5021 Bergen, Norway corrected
Surg Endosc 18:1528-34. 2004..The purpose of this study was to investigate the effect of the aldosterone receptor antagonist (potassium canrenoate) on renal hemodynamics and urinary output in pigs during increased intraabdominal pressure (IAP)...
- Acute aldosterone antagonism improves cardiac vagal control in humansJanine Fletcher
Department of Physiology, University of Birmingham, Edgbaston, Birmingham, United Kingdom
J Am Coll Cardiol 43:1270-5. 2004..We have examined the acute effects (<45 min) of aldosterone antagonism on heart rate variability and baroreflex sensitivity, markers of cardiac vagal control, in 13 healthy subjects...
- Cardiac, neuroadrenergic, and portal hemodynamic effects of prolonged aldosterone blockade in postviral child A cirrhosisMassimo Pozzi
Clinica Medica, Universita Milano Bicocca, Dipartimento di Radiologia, Ospedale San Gerardo, Monza, Italy
Am J Gastroenterol 100:1110-6. 2005....
- Aldosterone blunts human baroreflex sensitivity by a nongenomic mechanismB M W Schmidt
Institute of Clinical Pharmacology, University Hospital of Mannheim, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
Exp Clin Endocrinol Diabetes 113:252-6. 2005..Therefore, we conducted a clinical study to examine whether BRS, as measured by the phenylephrine method, is impaired in humans by aldosterone by a nongenomic mechanism...
- Effect of spironolactone, potassium canrenoate, and their common metabolite canrenone on Dimension Vista Digoxin AssayAmitava Dasgupta
Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School and Laboratory Services, Memorial Hermann Hospital at Texas Medical Center, Houston, Texas 77030, USA
J Clin Lab Anal 24:413-7. 2010....
- Abbott ARCHITECT clinical chemistry and immunoassay systems: digoxin assays are free of interferences from spironolactone, potassium canrenoate, and their common metabolite canrenoneAndrea Defrance
Abbott Diagnostics, Clinical Chemistry, Irving, TX, USA
Ther Drug Monit 33:128-31. 2011..We conclude that both the cDig and iDig assays on the ARCHITECT analyzers are free from interferences by spironolactone, potassium canrenoate, and canrenone...
- Amiloride reduces portal hypertension in rat liver cirrhosisChristian J Steib
Department of Medicine II Gastroenterology and Hepatology, Liver Center Munich, University of Munich e Grosshadern, Munich 81377, Germany
Gut 59:827-36. 2010..This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells...
- Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interactionKathleen M Knights
Department of Clinical Pharmacology, Flinders University School of Medicine, Adelaide, Australia
Drug Metab Dispos 38:1011-4. 2010....
- Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusionKatharina Schmidt
Department of Cardiology, Ernst Moritz Arndt University, Greifswald, Germany
Eur Heart J 31:1655-62. 2010..Here, we tested whether the MR antagonists potassium canrenoate and eplerenone could protect in the more clinically relevant schedule of administration at the end of ischaemia...
- Menopause not aldosterone-to-renin ratio predicts blood pressure response to a mineralocorticoid receptor antagonist in primary care hypertensive patientsOliviero Olivieri
Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
Am J Hypertens 21:976-82. 2008..We therefore designed an interventional study to ascertain whether primary care hypertensive patients with an elevated ARR presented a superior response to MRA treatment than subjects with normal ratio...
- Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptorHelen C Atkinson
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
Am J Physiol Endocrinol Metab 294:E1011-22. 2008....
- Prenatal corticosteroid exposure alters early developmental seizures and behaviorLIBOR VELISEK
Department of Cell Biology and Anatomy, Department of Pediatrics, New York Medical College, 15 Dana Rd, Valhalla, NY, USA Libor
Epilepsy Res 95:9-19. 2011..Thus, prenatal exposure to excess corticosteroids alters postnatal seizure susceptibility and behaviors. Specific effects may depend on corticosteroid species...
- Spontaneous resolution of idiopathic aldosteronism after long-term treatment with potassium canrenoateDecio Armanini
Hypertension 50:e69-70. 2007
- Mineralocorticoid receptor antagonistsHari Krishnan Parthasarathy
Hypertension Research Centre, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, DD1 9SY, UK
Curr Hypertens Rep 9:45-52. 2007..The re-emergence of mineralocorticoid receptor antagonists has provided clinicians with an important tool towards complete blockade of the renin-angiotensin-aldosterone axis...
- Renal sodium retention in cirrhotic rats depends on glucocorticoid-mediated activation of mineralocorticoid receptor due to decreased renal 11beta-HSD-2 activityHelle C Thiesson
Department of Physiology and Pharmacology, University of Southern Denmark, Odense
Am J Physiol Regul Integr Comp Physiol 292:R625-36. 2007..In addition, the overall potassium loss in the BDL model is due to increased fecal potassium excretion, which is associated with upregulation of ENaC in distal colon...
- Primary hyperaldosteronism is associated with derangement in the regulation of the hypothalamus-pituitary-adrenal axis in humansR Giordano
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
J Endocrinol Invest 30:558-63. 2007..Whether this hormonal alteration can influence the clinical feature of hypertensive patients with primary hyperaldosteronism needs to be clarified...
- Effects of canrenoate plus angiotensin-converting enzyme inhibitors versus angiotensin-converting enzyme inhibitors alone on systolic and diastolic function in patients with acute anterior myocardial infarctionPietro Di Pasquale
Division of Cardiology, Ingrassia Hospital, Palermo, Italy
Am Heart J 150:919. 2005..Aldosterone antagonism in combination with angiotensin-converting enzyme inhibition may better protect against the untoward effects of ALDO than angiotensin-converting enzyme inhibition alone...
- Hypothalamus-pituitary-adrenal hyperactivity in human aging is partially refractory to stimulation by mineralocorticoid receptor blockadeRoberta Giordano
Division of Endocrinology and Metabolism, Department of Internal Medicine, Ospedale Molinette, University of Turin, Italy
J Clin Endocrinol Metab 90:5656-62. 2005..Age-related HPA hyperactivity reflects impaired glucocorticoid feedback at the suprapituitary level...
- Idiopathic primary hyperaldosteronism: normalization of plasma aldosterone after one month withdrawal of long-term therapy with aldosterone-receptor antagonist potassium canrenoateD Armanini
Department of Medical and Surgical Sciences Endocrinology, University of Padua, Padua, Italy
J Endocrinol Invest 28:236-40. 2005..These data are consistent with possible regression of idiopathic primary hyperaldosteronism after long-term therapy with potassium canrenoate, or in alternative to a persistent effect of potassium canrenoate, on aldosterone synthesis...
- Effect of potassium canrenoate, an anti-aldosterone agent, on incidence of ascites and variceal progression in cirrhosisLuigi Bolondi
Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Clin Gastroenterol Hepatol 4:1395-402. 2006....
- [Potassium canrenoate and the combination of potassium canrenoate-butizide in the therapy of light to moderate arterial hypertension]S Morabito
Cattedra di Nefrologia, I Scuola di Specializzazione in Nefrologia, Universita degli Studi di Roma La Sapienza
Clin Ter 141:23-8. 1992..Serum potassium levels remained stable in all patients. Therefore, K-canrenoate in combination with butizide is an effective and well tolerated drug in the treatment of mild to moderate essential hypertension...
- Effects of acute mineralocorticoid and glucocorticoid receptor blockade on the excretion of an acute potassium load in healthy humansM van Buren
Department of Nephrology and Hypertension, University Hospital Utrecht, The Netherlands
J Clin Endocrinol Metab 77:902-9. 1993..The latter contrasts with data in adrenalectomized animals, in which situation glucocorticoid as well as aldosterone are indispensible for normal K tolerance...
- Natriuresis in conscious dogs caused by increased carotid [Na+] during angiotensin II and aldosterone blockadeC Emmeluth
Department of Medical Physiology, University of Copenhagen, Denmark
Acta Physiol Scand 151:403-11. 1994....
- Recognition of markers of response to potassium-canrenoate in essential hypertensionN Glorioso
Clinica Medica, University of Sassari, Italy
Steroids 60:105-9. 1995..Four HT dropped out because of low compliance, 6 because of reversible side effects, and 1 because blood pressure was not back to pre-treatment value after the second placebo period.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Stepped care medical treatment for cirrhotic ascites: analysis of factors influencing the response to treatmentA Takaya
Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan
J Gastroenterol Hepatol 10:30-5. 1995..In summary, this stepped care treatment is safe without any side effects, although the diuretics themselves may lead to relative vascular underfilling...
- Lymphocyte function tests in cirrhotic patients under treatment with spironolactone and potassium canrenoateR Cuppone
Department of Gastroenterology, La Sapienza University of Rome, Italy
J Int Med Res 16:436-42. 1988..Overall, however, both drugs may be regarded as safe, in terms of effects on lymphatic tissue, occurring during the course of cirrhosis...
- Time-dependent aldosterone metabolism in toad urinary bladderA S Brem
Division of Pediatric Nephrology, Rhode Island Hospital, Providence
Am J Physiol 254:F547-53. 1988..Both the generation of certain metabolites (e.g., 5 alpha-reductase pathway products) and the increase in Na+ transport can be selectively inhibited by K+-canrenoate...
- Antihypertensive effect of captopril, canrenoate potassium, and atenolol. Relations with red blood cell sodium transport and reninE Niutta
Istituto di Scienze Mediche, Scuola di Specializzazione in Nefrologia, University of Milano, Italy
Am J Hypertens 1:364-71. 1988We compared the antihypertensive efficacy of atenolol (100 mg/d), canrenoate potassium (200 mg/d), and captopril (75 mg/d) in 30 essential hypertensives...
- Comparative clinical study of spironolactone and potassium canrenoate. A randomized evaluation with double cross-overM Emili
Department of Gastroenterology, University of Rome La Sapienza, Italy
Arzneimittelforschung 38:1492-5. 1988..abstract truncated at 250 words)..
- The antihypertensive and renal activities of potassium canrenoate are associated with increased renal prostaglandin excretionS Castellani
Clinica Medica I, University of Florence, Italy
Clin Sci (Lond) 77:217-22. 1989....
- Canrenone and androgen receptor-active materials in plasma of cirrhotic patients during long-term K-canrenoate or spironolactone therapyA Andriulli
Divisione di Gastroenterologia, Ospedale San Giovanni Battista Molinette, Torino, Italia
Digestion 44:155-62. 1989..The lower incidence of antiandrogenic or estrogen-like side effects during K-canrenoate seems to be related to metabolites other than canrenone itself...
- [Effect of potassium canrenoate on the EP and Na+, K+ activities in endolymph]S Wakizono
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University
Nihon Jibiinkoka Gakkai Kaiho 93:373-80. 1990..There are no pathological changes both in the TEM view of the stria vascularis and in the SEM view of the hair cell. These results suggest that this drug may affect K+ conductance of the stria vascularis specifically...
- The difference in endocochlear and endolymphatic sac d.c. potentials in response to furosemide and canrenoate as diureticsN Mori
Department of Otolaryngology, Kagawa Medical School, Japan
Eur Arch Otorhinolaryngol 247:371-3. 1990..The differences in the EP and ESP in the response to the diuretics indicate a dissimilarity of the origin of both d.c. potentials in the endolymphatic space...
- Predicting interindividual variations in antihypertensive therapy: the role of sodium transport systems and reninE Niutta
Istituto di Scienze Mediche, University of Milan, Italy
J Hypertens Suppl 8:S53-8. 1990The efficacy of captopril at 75 mg/day, atenolol at 100 mg/day and canrenoate potassium at 200 mg/day was compared in 42 essential hypertensive patients in randomly assigned sequences...
- Influence of diuretics on brachial artery diameter and distensibility in hypertensive patientsS Laurent
Department of Internal Medicine, Broussais Hospital, Paris, France
Fundam Clin Pharmacol 4:685-93. 1990..The study indicates that, in hypertensive patients of middle age, diuretics did not change brachial artery diameter and distensibility, whether the drug caused an increase or a decrease in plasma potassium levels...
- Ototoxic effect of potassium canrenoate on the guinea pig cochleaS Komune
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Acta Otolaryngol 111:719-27. 1991..The potassium ion activity in the endolymph decreased slightly but the sodium ion activity remained unchanged during perfusion. These findings suggest that the main target of the PC is the cells of the stria vascularis...
- Rapid effects of mineralocorticoids on sodium-proton exchanger: genomic or nongenomic pathway?M Wehling
Medizinische Klinik Innenstadt, University of Munich, Federal Republic of Germany
Am J Physiol 260:E719-26. 1991..These putative novel receptors may in turn bind novel aldosterone antagonists with possible diuretic and vasodilator effects distinct from those of spironolactones...
- [Effect of potassium canrenoate on serum magnesium levels after extracorporeal circulation]K Tsuji
Second Department of Surgery, Okayama University School of Medicine
Kokyu To Junkan 40:813-8. 1992..05). These results suggested that administration of potassium canrenoate is useful for keeping and improving serum Mg levels after extracorporeal circulation...
- Torasemide in the treatment of patients with cirrhosis and ascitesP Gentilini
Istituto di Clinica Medica II, University of Florence School of Medicine, Italy
Cardiovasc Drugs Ther 7:81-5. 1993..The results of this study indicate that torasemide is suitable for the treatment of sodium retention in patients with cirrhosis and ascites...
- Regulation of renal hemodynamics after protein feeding: effects of proximal and distal diureticsL L Woods
Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland 97201 3098
Am J Physiol 264:R337-44. 1993....
- Effects of canrenoate on red cell sodium transport and calf flow in essential hypertensionA Semplicini
Clinica Medica I, University of Padua, Italy
Am J Hypertens 6:295-301. 1993..None of these parameters changed significantly in the other patients. Thus these data suggest that the fall in vascular resistance induced by canrenoate is mediated, in part, by the antagonism of endogenous ouabain-like factors...
- Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channelsRicardo Caballero
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
Circulation 107:889-95. 2003..In this study, the effects of SP and its metabolite, canrenoic acid (CA), on human ether-a-go-go-related gene (HERG) currents were analyzed...
- Bidirectional (positive/negative) interference of spironolactone, canrenone, and potassium canrenoate on serum digoxin measurement: elimination of interference by measuring free digoxin or using a chemiluminescent assay for digoxinAmitava Dasgupta
Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
J Clin Lab Anal 16:172-7. 2002..Another approach to avoid this interference is to use the CLIA digoxin assay...
- Mineralocorticoid receptor blockade by canrenoate increases both spontaneous and stimulated adrenal function in humansE Arvat
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
J Clin Endocrinol Metab 86:3176-81. 2001..These results also suggest that the stimulatory effect of CAN on HPA axis is mediated by concomitant modulation of CRH and AVP release...
- Additional beneficial effects of canrenoate in patients with anterior myocardial infarction on ACE-inhibitor treatment. A pilot studyP Di Pasquale
Division of Cardiology Paolo Borsellino, G E Ingrassia Hospital, Palermo, Italy
Ital Heart J 2:121-9. 2001..Recent evidence suggests that, via the mineralocorticoid receptors present in cardiovascular tissues, aldosterone exerts profibrotic effects, and that partial aldosterone escape occurs during ACE-inhibitor treatment...
- The combination ace-inhibitors plus canreonate in patients with anterior myocardial infarction: safety and tolerability studyP Di Pasquale
Division of Cardiology, Paolo Borsellino, G F Ingrassia Hospital, Palermo, Italy
Int J Cardiol 77:119-27; discussion 128-9. 2001..There is recent evidence that aldosterone (ALDO) exerts pro-fibrotic effects, acting via the mineral-corticoid receptors in cardiovascular tissues and partial aldosterone escape during ACE-inhibition treatment occurs...
- Decreased vasopressin-mediated renal water reabsorption in rats with chronic aldosterone-receptor blockadeT E Jonassen
Department of Pharmacology, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
Am J Physiol Renal Physiol 278:F246-56. 2000..This strongly supports the view that aldosterone plays a significant role for vasopressin-mediated water reabsorption...
- Intralymphocyte free magnesium in patients with primary aldosteronism: aldosterone and lymphocyte magnesium homeostasisP Delva
Departments of Biomedic and Surgical Sciences, University of Verona, Policlinico Borgo Roma, Verona, Italy
Hypertension 35:113-7. 2000..The data are consistent with the hypothesis that aldosterone affects the cellular homeostasis of magnesium, probably through modification of the activity of the Na(+)-Mg(2+) antiporter...
- Memory consolidation in human sleep depends on inhibition of glucocorticoid releaseW Plihal
Georg Elias Müller Institute of Psychology, University of Gottingen, Germany
Neuroreport 10:2741-7. 1999..Blocking mineralocorticoid receptors by canrenoate did not affect memory, suggesting inactivation of glucocorticoid receptors to be the essential prerequisite for memory consolidation during early sleep...
- Aldosterone metabolism in cultures of rat renal cortical and medullary cellsM Egfjord
Medical Department P, Rigshospitalet, Copenhagen, Denmark
Scand J Clin Lab Invest 59:107-13. 1999..This indicated that the metabolism might play some role in modulation of the intracellular response to aldosterone in the kidney...
- Different sensitivity to hydrochlorothiazide and to potassium-canrenoate among essential hypertensive patientsN Glorioso
Hypertension Center, University of Sassari, Viale S Pietro, Italy
Clin Exp Hypertens 15:187-96. 1993..Their selective response to K-Can suggest a peculiar pathogenetic mechanism underlying their high blood pressure...
- Increase in the basal tone of guinea pig thoracic aorta induced by ouabain is inhibited by spironolactone canrenone and potassium canrenoateR Sorrentino
Department of Experimental Pharmacology, University of Naples Federico II, Italy
J Cardiovasc Pharmacol 28:519-25. 1996..Our results may indicate that spironolactone, canrenone, and potassium canrenoate act in hypertension by interfering with mechanisms in which an ouabain-like factor is involved...
- Blocking of central nervous mineralocorticoid receptors counteracts inhibition of pituitary-adrenal activity in human sleepJ Born
Department of Internal Medicine, University of Lubeck, Germany
J Clin Endocrinol Metab 82:1106-10. 1997..The inhibition disappearance after blockage of MR suggests that sleep exerts this influence via central nervous MR-expressing cells. These cells seem to be simultaneously involved in the generation of slow-wave sleep...
- Cross-reactivity of TDX and OPUS immunoassay systems for serum digoxin determinationM Okazaki
Department of Hospital Pharmacy, School of Medicine, Kobe University, Japan
Ther Drug Monit 19:657-62. 1997..The authors found OPUS more useful for monitoring serum digoxin concentrations in patients because of its superior specificity...
- Inhibitory effect of aldosterone on the natriuretic response to atrial natriuretic peptide in hypocapnic ratsH Kanauchi
Department of Surgery, University of Tokyo, Japan
Clin Exp Pharmacol Physiol 25:607-11. 1998..The data suggest that aldosterone plays an important role by limiting the renal actions of ANP during acute hypocapnia...
- Aldosterone receptor blockade inhibits increased furosemide-sensitive sodium reabsorption in rats with liver cirrhosisT E Jonassen
Department of Pharmacology, the Panu Institute, University of Copenhagen, Denmark
J Pharmacol Exp Ther 287:931-6. 1998..These data suggest that chronic aldosterone receptor blockade with canrenoate prevents sodium retention in cirrhotic rats partly by inhibition of increased sodium reabsorption in the thick ascending limb...
- Albumin improves the response to diuretics in patients with cirrhosis and ascites: results of a randomized, controlled trialP Gentilini
Institute of Internal Medicine, University of Florence School of Medicine, Italy
J Hepatol 30:639-45. 1999..We investigated whether intravascular volume expansion with albumin exert beneficial effects in cirrhosis with ascites...
- Rationale for an early aldosterone blockade in acute myocardial infarction and design of the ALBATROSS trialFarzin Beygui
Institut de Cardiologie and INSERM U937, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
Am Heart J 160:642-8. 2010..Angiotensin-converting enzyme inhibitors have delayed partial and temporary effects on aldosterone levels. We hypothesize that aldosterone receptor blockade, early after AMI onset on top of standard therapy, may improve clinical outcome...
- Aldosterone blockade in patients with acute myocardial infarctionHenry A Solomon
Circulation 108:E173; author reply E173. 2003
- Antimineralocorticoid canrenoate enhances secretory activity of the hypothalamus-pituitary-adrenocortical (HPA) axis in humansC Dodt
Department of Internal Medicine, Medical University of Lubeck, FRG
Neuroendocrinology 58:570-4. 1993..05). Changes induced by canrenoate paralleling those in animals after intracerebroventricular administration of MR antagonists suggest that central nervous MRs are involved in the regulation of HPA secretory activity also in humans...
- Vasopressin and angiotensin II in the conscious dog: synergistic effects on renal excretory parameters?P Eiken
Department of Medical Physiology C, Panum Institute, University of Copenhagen, Denmark
Clin Sci (Lond) 83:467-75. 1992..Vasopressin alone exerted its antidiuretic effect without affecting plasma renin activity, plasma aldosterone concentration or renal excretion of Na+ and K+.(ABSTRACT TRUNCATED AT 250 WORDS)..
- The stimulatory effect of canrenoate, a mineralocorticoid antagonist, on the activity of the hypothalamus-pituitary-adrenal axis is abolished by alprazolam, a benzodiazepine, in humansS Grottoli
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
J Clin Endocrinol Metab 87:4616-20. 2002..These findings emphasize the role of GABA in the control of the HPA axis in humans...