canrenoate potassium

Summary

Summary: A synthetic pregnadiene derivative with anti-aldosterone activity.

Top Publications

  1. ncbi Difference in metabolic profile of potassium canrenoate and spironolactone in the rat: mutagenic metabolites unique to potassium canrenoate
    C S Cook
    Division of Product Safety Assessment, G D Searle and Co, Skokie, IL 60077
    Arch Toxicol 61:201-12. 1988
  2. ncbi Genotoxicity testing of potassium canrenoate in cultured rat and human cells
    A Martelli
    Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, I 16132 Genoa, Italy
    Mutagenesis 14:463-72. 1999
  3. ncbi Involvement of cytochrome P-450IIIA in metabolism of potassium canrenoate to an epoxide: mechanism of inhibition of the epoxide formation by spironolactone and its sulfur-containing metabolite
    C S Cook
    Department of Drug Metabolism, G D Searle and Co, Skokie, Illinois
    J Pharmacol Exp Ther 266:1-7. 1993
  4. ncbi DNA damage in tissues of rat treated with potassium canrenoate
    Antonietta Martelli
    Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Tossicologia Clinica, Viale Benedetto XV 2, I 16132, Genoa, Italy
    Toxicology 171:95-103. 2002
  5. ncbi Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone
    Monica Minnaard-Huiban
    Department of Pharmacology and Toxicology, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Endocrinology 149:28-31. 2008
  6. pmc Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channels
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 146:146-61. 2005
  7. ncbi Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis
    Morag Young
    Endocrine Genetics, Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Endocrinology 144:3848-51. 2003
  8. ncbi A new turbidometric digoxin immunoassay on the ADVIA 1650 analyzer is free from interference by spironolactone, potassium canrenoate, and their common metabolite canrenone
    Pradip Datta
    Bayer Diagnostics, Tarrytown, New York, USA
    Ther Drug Monit 25:478-82. 2003
  9. ncbi Efficacy and safety of the stepped care medical treatment of ascites in liver cirrhosis: a randomized controlled clinical trial comparing two diets with different sodium content
    M Bernardi
    Cattedra di Patologia Speciale Medica I, University of Bologna, Italy
    Liver 13:156-62. 1993
  10. ncbi ACE-inhibition plus mineralocorticoid antagonism versus ACE-inhibition alone in patients with anterior myocardial infarction
    P Di Pasquale
    Division of Cardiology Paolo Borsellino, G F Ingrassia Hospital, Palermo, Italy
    Cardiovasc Drugs Ther 15:309-14. 2001

Scientific Experts

  • A Dasgupta
  • Yasir Hasan Siddique
  • F Andreasen
  • Decio Armanini
  • Bernhard M W Schmidt
  • Christian J Steib
  • Morag Young
  • S Takeda
  • Kathleen M Knights
  • Yoshiyuki Kagawa
  • L Bolondi
  • Peter Wellhoener
  • P Delva
  • G Splendiani
  • Oliviero Olivieri
  • A Sugiyama
  • P Angeli
  • LIBOR VELISEK
  • P Di Pasquale
  • Romain Bos
  • R Giordano
  • E Arvat
  • Roberta Giordano
  • Luminita H Pojoga
  • Maysa Suyagh
  • Melissa Lingis
  • Andrea Defrance
  • Ricardo Caballero
  • Katharina Schmidt
  • Wenxia Chai
  • M Pellegrino
  • Farzin Beygui
  • E Ghigo
  • Rita Berardelli
  • Maureen Keller-Wood
  • T E Jonassen
  • Helen C Atkinson
  • Caroline Rugale
  • Monica Minnaard-Huiban
  • Seth A Reini
  • Andreea Picu
  • Ezio Ghigo
  • Emanuela Arvat
  • Helle C Thiesson
  • Hari Krishnan Parthasarathy
  • S Paterna
  • A Scandurra
  • R Sorrentino
  • Ricardo Gomez
  • Massimo Pozzi
  • Pietro Di Pasquale
  • Odile Mediani
  • Philippe Lechat
  • Paul M Vanhoutte
  • Nathalie Mougenot
  • F F Gudmundsson
  • Peter Riis Hansen
  • M Maccario
  • Janine Fletcher
  • Juan Tamargo
  • Eva Delpón
  • P Gentilini
  • Henry A Solomon
  • Pradip Datta
  • J Born
  • Antonietta Martelli
  • S Grottoli
  • B Maccagno
  • Gail K Adler
  • S Cannizzaro
  • Ahmed F Hawwa
  • Henry L Halliday
  • Enrique R Maldonado
  • Alexander Turchin
  • Muriel Millar
  • Gordon H Williams
  • Prashant Kole
  • Patricia Coutinho
  • Rodeler Youte
  • Alicia Rivera
  • James C McElnay
  • Jose R Romero
  • Mike D Shields
  • S Scalzo
  • A Giubilato
  • Jeffrey S Millership
  • G Deschenes
  • Jonathan Williams
  • Paul S Collier
  • Tham M Yao

Detail Information

Publications101 found, 100 shown here

  1. ncbi Difference in metabolic profile of potassium canrenoate and spironolactone in the rat: mutagenic metabolites unique to potassium canrenoate
    C S Cook
    Division of Product Safety Assessment, G D Searle and Co, Skokie, IL 60077
    Arch Toxicol 61:201-12. 1988
    ..Absence of the CAN epoxide pathway in the metabolism of SP provides a possible explanation for the observed differences in the toxicological profiles of the two compounds...
  2. ncbi Genotoxicity testing of potassium canrenoate in cultured rat and human cells
    A Martelli
    Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, I 16132 Genoa, Italy
    Mutagenesis 14:463-72. 1999
    ....
  3. ncbi Involvement of cytochrome P-450IIIA in metabolism of potassium canrenoate to an epoxide: mechanism of inhibition of the epoxide formation by spironolactone and its sulfur-containing metabolite
    C S Cook
    Department of Drug Metabolism, G D Searle and Co, Skokie, Illinois
    J Pharmacol Exp Ther 266:1-7. 1993
    ..Inhibition of PC metabolism to 6 beta, 7 beta-epoxy-CAN by TAO and erythromycin, and its induction by DEX and PCN, suggest involvement of Cyt P-450IIIA, which is in turn inhibited by SP and 7 alpha-thio-spirolactone...
  4. ncbi DNA damage in tissues of rat treated with potassium canrenoate
    Antonietta Martelli
    Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Tossicologia Clinica, Viale Benedetto XV 2, I 16132, Genoa, Italy
    Toxicology 171:95-103. 2002
    ..A high and dose-dependent frequency of DNA lesions was found to occur in testes and ovaries of rats given single doses ranging from 1/8 to 1/2 LD50...
  5. ncbi Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone
    Monica Minnaard-Huiban
    Department of Pharmacology and Toxicology, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Endocrinology 149:28-31. 2008
    ....
  6. pmc Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channels
    Ricardo Gomez
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 146:146-61. 2005
    ..Blockade of these cardiac K(+) currents, together with the antagonism of the aldosterone proarrhythmic effects produced by SP, might be highly desirable for the treatment of supraventricular arrhythmias...
  7. ncbi Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis
    Morag Young
    Endocrine Genetics, Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
    Endocrinology 144:3848-51. 2003
    ....
  8. ncbi A new turbidometric digoxin immunoassay on the ADVIA 1650 analyzer is free from interference by spironolactone, potassium canrenoate, and their common metabolite canrenone
    Pradip Datta
    Bayer Diagnostics, Tarrytown, New York, USA
    Ther Drug Monit 25:478-82. 2003
    ..We conclude that the new turbidometric assay for digoxin is free from interference by spironolactone, potassium canrenoate, and their common metabolite canrenone...
  9. ncbi Efficacy and safety of the stepped care medical treatment of ascites in liver cirrhosis: a randomized controlled clinical trial comparing two diets with different sodium content
    M Bernardi
    Cattedra di Patologia Speciale Medica I, University of Bologna, Italy
    Liver 13:156-62. 1993
    ..Multivariate analysis showed that creatinine clearance and plasma aldosterone were independent predictive factors of the response to treatment.(ABSTRACT TRUNCATED AT 250 WORDS)..
  10. ncbi ACE-inhibition plus mineralocorticoid antagonism versus ACE-inhibition alone in patients with anterior myocardial infarction
    P Di Pasquale
    Division of Cardiology Paolo Borsellino, G F Ingrassia Hospital, Palermo, Italy
    Cardiovasc Drugs Ther 15:309-14. 2001
    ..Aldosterone antagonism in combination with ACE inhibition may better protect against untoward effects of aldosterone than ACE inhibition alone...
  11. ncbi Randomized clinical study of the efficacy of amiloride and potassium canrenoate in nonazotemic cirrhotic patients with ascites
    P Angeli
    Department of Clinical Medicine, University of Padua, Italy
    Hepatology 19:72-9. 1994
    ..abstract truncated at 250 words)..
  12. ncbi Time-course reduction of renal function in rats on high sodium intake: acute reversal by potassium canrenoate
    Caroline Rugale
    Groupe Rein et Hypertension, Montpellier University, Montpellier, France
    Clin Exp Pharmacol Physiol 35:412-5. 2008
    ..The beneficial effect of acute administration of potassium canrenoate favours the participation of aldosterone, at least partially, in the sustained deterioration of renal function after 21 weeks of high sodium feeding...
  13. ncbi Collecting duct is a site of sodium retention in PAN nephrosis: a rationale for amiloride therapy
    G Deschenes
    Service de Nephrologie Pediatrique, Hôpital Armand Trousseau Assistance Publique Hôpitaux de Paris, Paris, France
    J Am Soc Nephrol 12:598-601. 2001
    ....
  14. ncbi Elevated resting and exercise-induced cortisol levels after mineralocorticoid receptor blockade with canrenoate in healthy humans
    Peter Wellhoener
    Department of Internal Medicine I, University Hospital Schleswig Holstein, D 23538 Luebeck, Germany
    J Clin Endocrinol Metab 89:5048-52. 2004
    ..The undiminished concentration of ACTH in the presence of elevated cortisol levels suggests that blockade of MR shifts the set point for cortisol feedback inhibition of the HPA axis toward higher cortisol levels...
  15. ncbi Steroidogenesis vs. steroid uptake in the heart: do corticosteroids mediate effects via cardiac mineralocorticoid receptors?
    Wenxia Chai
    Division of Pharmacology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hypertens 28:1044-53. 2010
    ..To test whether glucocorticoids act as the endogenous agonist of cardiac mineralocorticoid receptors, we evaluated the cardiac effects of aldosterone and corticosterone and cardiac steroidogenesis vs. steroid uptake from plasma...
  16. ncbi Effects of canrenoate potassium, an aldosterone antagonist on portal hemodynamics in patients with compensated liver cirrhosis
    M Koda
    Department of Clinical Laboratory Medicine, Tottori University, Faculty of Medicine, Japan
    Hepatogastroenterology 43:887-92. 1996
    ..We examined the effects of acute administration of canrenoate potassium, an aldosterone antagonist, on portal hemodynamics in compensated cirrhotic patients using noninvasive ..
  17. ncbi Effect of spironolactone and its metabolites on contractile property of isolated rat aorta rings
    R Sorrentino
    Department of Experimental Pharmacology, Naples, Italy
    J Cardiovasc Pharmacol 36:230-5. 2000
    ..Because both phenylephrine- and KCl-induced contractions imply an intracellular Ca2+ influx, we suggest that these drugs could act through an inhibition of voltage-dependent Ca2+ channels...
  18. ncbi Effect of intravenously applied canrenoate on ampullar endolymphatic potential
    K Yura
    Department of Otolaryngology, Kagawa Medical School, Japan
    Acta Otolaryngol 115:648-52. 1995
    ..Pretreatment with aldosterone attenuated the AEP change produced by canrenoate. The results suggest that aldosterone may be involved in the modulation of ampullar function...
  19. ncbi Suppression of surgical hyperaldosteronism by potassium canrenoate during gynecologic surgery under sevoflurane anesthesia
    T Watanabe
    Department of Anesthesiology, Nippon Medical School, Tokyo, Japan
    Acta Anaesthesiol Scand 44:758-62. 2000
    ..This study investigated the effect of potassium canrenoate (PC) on pituitary adrenocortical function in lower abdominal surgery under sevoflurane anesthesia...
  20. ncbi Inhibition of catecholamine-induced cardiac fibrosis by an aldosterone antagonist
    Romain Bos
    Service de Pharmacologie, CHU Pitie Salpetriere, Paris, France
    J Cardiovasc Pharmacol 45:8-13. 2005
    ..These results suggest a transregulation between the adrenergic and mineralocorticoid pathways, most likely at the nucleus level, with activation of profibrotic genes...
  21. pmc Cardiac corticosteroid receptors mediate the enlargement of the ovine fetal heart induced by chronic increases in maternal cortisol
    Seth A Reini
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Box 100487, Gainesville, Florida 32610 0487, USA
    J Endocrinol 198:419-27. 2008
    ....
  22. ncbi Mechanism of ursodeoxycholic acid- and canrenoate-induced biliary bicarbonate secretion and the effect on glucose- and amino acid-induced cholestasis
    E Omland
    Dept of Surgery B, National Hospital Rikshospitalet, University of Oslo, Norway
    Scand J Gastroenterol 26:513-22. 1991
    ..The effect of UDCA or canrenoate on bile secretion is not disturbed by glucose or amino acids. Both substances stimulate canalicular bicarbonate secretion and could be of importance in improving cholestatic conditions...
  23. ncbi Extrarenal role of aldosterone in the regulation of blood pressure
    M Yamakado
    Department of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan
    Am J Hypertens 1:276-9. 1988
    To assess the hypothesis that aldosterone may have direct vasoconstrictive action, the acute effects of canrenoate potassium (Soldactone, S), an aldosterone antagonist, on hemodynamics and hormonal responses were determined before and ..
  24. ncbi Effects of a low-sodium diet on electrolyte transport in the proximal and distal colon of the guinea pig (Cavia porcellus)
    G Rechkemmer
    Department of Physiology, School of Veterinary Medicine, Bischofsholer Damm, Hannover, Federal Republic of Germany
    Comp Biochem Physiol Comp Physiol 103:501-5. 1992
    ..In the distal colon Na absorption was abolished by luminal amiloride and the transepithelial PD was reversed in polarity. 7. K-canrenoate treatment prevented the increase in Na transport in the distal colon...
  25. pmc Population pharmacokinetic model of canrenone after intravenous administration of potassium canrenoate to paediatric patients
    Maysa Suyagh
    Clinical and Practice Research Group, School of Pharmacy, Queen s University Belfast, 97 Lisburn Road, Belfast, UK
    Br J Clin Pharmacol 74:864-72. 2012
    ..Little is known about the pharmacokinetics of potassium canrenoate/canrenone in paediatric patients..
  26. pmc Activation of the mineralocorticoid receptor increases striatin levels
    Luminita H Pojoga
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 25:243-9. 2012
    ..Striatin, a membrane associated protein, interacts with estrogen receptors in endothelial cells...
  27. ncbi [Diuretic therapy in heart failure]
    G Splendiani
    Dipartimento di Nefrologia e Dialisi, Policlinico Tor Vergata, Rome
    G Ital Nefrol 23:S74-6. 2006
    ..sodium channel inhibitors: amiloride and triamterene; b) aldosterone receptor antagonists: spironolactone, canrenoate potassium, eplerenone; 6) ADH antagonists: lithium salts, demeclocycline and ethanol...
  28. pmc Differential effects of mineralocorticoid blockade on the hypothalamo-pituitary-adrenal axis in pregnant and nonpregnant ewes
    Melissa Lingis
    Dept of Pharmacodynamics, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Am J Physiol Endocrinol Metab 300:E592-9. 2011
    ....
  29. ncbi Aldosterone influences free intracellular calcium in human mononuclear leukocytes in vitro
    M Wehling
    Medizinische Klinik, University of Munich, FRG
    Cell Calcium 11:565-71. 1990
    ..These results show that aldosterone exerts an effect on the [Ca2+]i in HML in vitro which could be involved in hemodynamic responses to mineralocorticoids if also present in cardiovascular tissues...
  30. ncbi Reversible pharmacokinetic profiles of canrenoic acid and its biotransformed product. Canrenone in the rat
    S Asada
    Kobe Women s College of Pharmacy, Japan
    Chem Pharm Bull (Tokyo) 38:1012-8. 1990
    ..Simultaneous computer multi-line fitting of plasma concentration-time data was carried out and the adequacy of pharmacokinetic parameters in this model was tested using the iterative nonlinear least-squares regression program, MULTI...
  31. ncbi Effect of spironolactone, potassium canrenoate and their common metabolite canrenone on serum digoxin measurement by digoxin III, a new digoxin immunoassay
    Amitava Dasgupta
    Department of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas 77030, USA
    Ther Drug Monit 30:744-7. 2008
    ..We conclude that spironolactone, potassium canrenoate, and their common metabolite canrenone interfere with the serum digoxin measurements using the new Digoxin III assay...
  32. ncbi Combined versus sequential diuretic treatment of ascites in non-azotaemic patients with cirrhosis: results of an open randomised clinical trial
    P Angeli
    Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, Padova, Italy
    Gut 59:98-104. 2010
    ..The aim of the study was to compare sequential versus combined diuretic therapy in patients with cirrhosis, moderate ascites and without renal failure...
  33. ncbi Effect of acute and prolonged mineralocorticoid receptor blockade on spontaneous and stimulated hypothalamic-pituitary-adrenal axis in humans
    Rita Berardelli
    Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Ospedale S Giovanni Battista Molinette, C so Dogliotti 14, Turin, Italy
    Eur J Endocrinol 162:1067-74. 2010
    ..Our study was performed in order to clarify this point...
  34. ncbi Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat
    Romain Bos
    Service de Pharmacologie, CHU Pitie Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    J Pharmacol Exp Ther 309:1160-6. 2004
    ..Potassium canrenoate attenuated the fibrosis but not the enhanced dilatation of the left ventricle induced by isoprenaline...
  35. ncbi Clinically insignificant negative interferences of spironolactone, potassium canrenoate, and their common metabolite canrenone in new dimension vista LOCI digoxin immunoassay
    Amitava Dasgupta
    Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Clin Lab Anal 26:143-7. 2012
    ..However, such small bias may not have any clinical significance. We conclude that new Dimension Vista LOCI digoxin assay is virtually free from interferences of spironolactone, potassium canrenoate, and their common metabolite canrenone...
  36. pmc Effect of the steroid K-canrenoate on hsp70 expression and tissue damage in transgenic Drosophila melanogaster (hsp70-lacZ) Bg9
    Yasir Hasan Siddique
    Drosophila Transgenics Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U P, 202002, India
    J Insect Sci 12:92. 2012
    ..The results of the present study suggest that the K-canrenoate at 0.8 and 1.0 µL/mL is cytotoxic and caused tissue damage in the third instar larvae of transgenic D. melanogaster (hsp70-lacZ) Bg(9)...
  37. ncbi Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells
    Peter Riis Hansen
    Department of Cardiology P, Gentofte University Hospital, DK 2900 Hellerup, Denmark
    Immunol Lett 91:87-91. 2004
    ..Overexpression of proinflammatory cytokines contribute to the development and progression of CHF...
  38. ncbi Comparative evaluation of digoxin concentrations determined by three assay systems: TDx, IMx and OPUS
    Yoshiyuki Kagawa
    Department of Hospital Pharmacy, Mie University School of Medicine, Edobashi 2 174, Tsu City, Mie 514 8507, Japan
    Biopharm Drug Dispos 25:21-6. 2004
    ..These results suggest that OPUS has a higher specificity for measuring the plasma digoxin concentrations compared with TDx or IMx...
  39. ncbi Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine model
    Atsushi Sugiyama
    Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
    J Pharmacol Sci 96:436-43. 2004
    ....
  40. ncbi Effects of the aldosterone receptor antagonist potassium canrenoate on renal blood flow and urinary output during prolonged increased intraabdominal pressure (IAP) in pigs
    F F Gudmundsson
    Surgical Research Laboratory, Department of Surgical Sciences, University of Bergen, 5021 Bergen, Norway corrected
    Surg Endosc 18:1528-34. 2004
    ..The purpose of this study was to investigate the effect of the aldosterone receptor antagonist (potassium canrenoate) on renal hemodynamics and urinary output in pigs during increased intraabdominal pressure (IAP)...
  41. ncbi Acute aldosterone antagonism improves cardiac vagal control in humans
    Janine Fletcher
    Department of Physiology, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    J Am Coll Cardiol 43:1270-5. 2004
    ..We have examined the acute effects (<45 min) of aldosterone antagonism on heart rate variability and baroreflex sensitivity, markers of cardiac vagal control, in 13 healthy subjects...
  42. ncbi Cardiac, neuroadrenergic, and portal hemodynamic effects of prolonged aldosterone blockade in postviral child A cirrhosis
    Massimo Pozzi
    Clinica Medica, Universita Milano Bicocca, Dipartimento di Radiologia, Ospedale San Gerardo, Monza, Italy
    Am J Gastroenterol 100:1110-6. 2005
    ....
  43. ncbi Aldosterone blunts human baroreflex sensitivity by a nongenomic mechanism
    B M W Schmidt
    Institute of Clinical Pharmacology, University Hospital of Mannheim, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Exp Clin Endocrinol Diabetes 113:252-6. 2005
    ..Therefore, we conducted a clinical study to examine whether BRS, as measured by the phenylephrine method, is impaired in humans by aldosterone by a nongenomic mechanism...
  44. ncbi Effect of spironolactone, potassium canrenoate, and their common metabolite canrenone on Dimension Vista Digoxin Assay
    Amitava Dasgupta
    Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School and Laboratory Services, Memorial Hermann Hospital at Texas Medical Center, Houston, Texas 77030, USA
    J Clin Lab Anal 24:413-7. 2010
    ....
  45. ncbi Abbott ARCHITECT clinical chemistry and immunoassay systems: digoxin assays are free of interferences from spironolactone, potassium canrenoate, and their common metabolite canrenone
    Andrea Defrance
    Abbott Diagnostics, Clinical Chemistry, Irving, TX, USA
    Ther Drug Monit 33:128-31. 2011
    ..We conclude that both the cDig and iDig assays on the ARCHITECT analyzers are free from interferences by spironolactone, potassium canrenoate, and canrenone...
  46. ncbi Amiloride reduces portal hypertension in rat liver cirrhosis
    Christian J Steib
    Department of Medicine II Gastroenterology and Hepatology, Liver Center Munich, University of Munich e Grosshadern, Munich 81377, Germany
    Gut 59:827-36. 2010
    ..This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells...
  47. ncbi Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18beta-glucuronidation: a potential drug interaction
    Kathleen M Knights
    Department of Clinical Pharmacology, Flinders University School of Medicine, Adelaide, Australia
    Drug Metab Dispos 38:1011-4. 2010
    ....
  48. pmc Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion
    Katharina Schmidt
    Department of Cardiology, Ernst Moritz Arndt University, Greifswald, Germany
    Eur Heart J 31:1655-62. 2010
    ..Here, we tested whether the MR antagonists potassium canrenoate and eplerenone could protect in the more clinically relevant schedule of administration at the end of ischaemia...
  49. ncbi Menopause not aldosterone-to-renin ratio predicts blood pressure response to a mineralocorticoid receptor antagonist in primary care hypertensive patients
    Oliviero Olivieri
    Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Am J Hypertens 21:976-82. 2008
    ..We therefore designed an interventional study to ascertain whether primary care hypertensive patients with an elevated ARR presented a superior response to MRA treatment than subjects with normal ratio...
  50. ncbi Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor
    Helen C Atkinson
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    Am J Physiol Endocrinol Metab 294:E1011-22. 2008
    ....
  51. pmc Prenatal corticosteroid exposure alters early developmental seizures and behavior
    LIBOR VELISEK
    Department of Cell Biology and Anatomy, Department of Pediatrics, New York Medical College, 15 Dana Rd, Valhalla, NY, USA Libor
    Epilepsy Res 95:9-19. 2011
    ..Thus, prenatal exposure to excess corticosteroids alters postnatal seizure susceptibility and behaviors. Specific effects may depend on corticosteroid species...
  52. ncbi Spontaneous resolution of idiopathic aldosteronism after long-term treatment with potassium canrenoate
    Decio Armanini
    Hypertension 50:e69-70. 2007
  53. ncbi Mineralocorticoid receptor antagonists
    Hari Krishnan Parthasarathy
    Hypertension Research Centre, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, DD1 9SY, UK
    Curr Hypertens Rep 9:45-52. 2007
    ..The re-emergence of mineralocorticoid receptor antagonists has provided clinicians with an important tool towards complete blockade of the renin-angiotensin-aldosterone axis...
  54. ncbi Renal sodium retention in cirrhotic rats depends on glucocorticoid-mediated activation of mineralocorticoid receptor due to decreased renal 11beta-HSD-2 activity
    Helle C Thiesson
    Department of Physiology and Pharmacology, University of Southern Denmark, Odense
    Am J Physiol Regul Integr Comp Physiol 292:R625-36. 2007
    ..In addition, the overall potassium loss in the BDL model is due to increased fecal potassium excretion, which is associated with upregulation of ENaC in distal colon...
  55. ncbi Primary hyperaldosteronism is associated with derangement in the regulation of the hypothalamus-pituitary-adrenal axis in humans
    R Giordano
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    J Endocrinol Invest 30:558-63. 2007
    ..Whether this hormonal alteration can influence the clinical feature of hypertensive patients with primary hyperaldosteronism needs to be clarified...
  56. ncbi Effects of canrenoate plus angiotensin-converting enzyme inhibitors versus angiotensin-converting enzyme inhibitors alone on systolic and diastolic function in patients with acute anterior myocardial infarction
    Pietro Di Pasquale
    Division of Cardiology, Ingrassia Hospital, Palermo, Italy
    Am Heart J 150:919. 2005
    ..Aldosterone antagonism in combination with angiotensin-converting enzyme inhibition may better protect against the untoward effects of ALDO than angiotensin-converting enzyme inhibition alone...
  57. ncbi Hypothalamus-pituitary-adrenal hyperactivity in human aging is partially refractory to stimulation by mineralocorticoid receptor blockade
    Roberta Giordano
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Ospedale Molinette, University of Turin, Italy
    J Clin Endocrinol Metab 90:5656-62. 2005
    ..Age-related HPA hyperactivity reflects impaired glucocorticoid feedback at the suprapituitary level...
  58. ncbi Idiopathic primary hyperaldosteronism: normalization of plasma aldosterone after one month withdrawal of long-term therapy with aldosterone-receptor antagonist potassium canrenoate
    D Armanini
    Department of Medical and Surgical Sciences Endocrinology, University of Padua, Padua, Italy
    J Endocrinol Invest 28:236-40. 2005
    ..These data are consistent with possible regression of idiopathic primary hyperaldosteronism after long-term therapy with potassium canrenoate, or in alternative to a persistent effect of potassium canrenoate, on aldosterone synthesis...
  59. ncbi Effect of potassium canrenoate, an anti-aldosterone agent, on incidence of ascites and variceal progression in cirrhosis
    Luigi Bolondi
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Clin Gastroenterol Hepatol 4:1395-402. 2006
    ....
  60. ncbi [Potassium canrenoate and the combination of potassium canrenoate-butizide in the therapy of light to moderate arterial hypertension]
    S Morabito
    Cattedra di Nefrologia, I Scuola di Specializzazione in Nefrologia, Universita degli Studi di Roma La Sapienza
    Clin Ter 141:23-8. 1992
    ..Serum potassium levels remained stable in all patients. Therefore, K-canrenoate in combination with butizide is an effective and well tolerated drug in the treatment of mild to moderate essential hypertension...
  61. ncbi Effects of acute mineralocorticoid and glucocorticoid receptor blockade on the excretion of an acute potassium load in healthy humans
    M van Buren
    Department of Nephrology and Hypertension, University Hospital Utrecht, The Netherlands
    J Clin Endocrinol Metab 77:902-9. 1993
    ..The latter contrasts with data in adrenalectomized animals, in which situation glucocorticoid as well as aldosterone are indispensible for normal K tolerance...
  62. ncbi Natriuresis in conscious dogs caused by increased carotid [Na+] during angiotensin II and aldosterone blockade
    C Emmeluth
    Department of Medical Physiology, University of Copenhagen, Denmark
    Acta Physiol Scand 151:403-11. 1994
    ....
  63. ncbi Recognition of markers of response to potassium-canrenoate in essential hypertension
    N Glorioso
    Clinica Medica, University of Sassari, Italy
    Steroids 60:105-9. 1995
    ..Four HT dropped out because of low compliance, 6 because of reversible side effects, and 1 because blood pressure was not back to pre-treatment value after the second placebo period.(ABSTRACT TRUNCATED AT 250 WORDS)..
  64. ncbi Stepped care medical treatment for cirrhotic ascites: analysis of factors influencing the response to treatment
    A Takaya
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    J Gastroenterol Hepatol 10:30-5. 1995
    ..In summary, this stepped care treatment is safe without any side effects, although the diuretics themselves may lead to relative vascular underfilling...
  65. ncbi Lymphocyte function tests in cirrhotic patients under treatment with spironolactone and potassium canrenoate
    R Cuppone
    Department of Gastroenterology, La Sapienza University of Rome, Italy
    J Int Med Res 16:436-42. 1988
    ..Overall, however, both drugs may be regarded as safe, in terms of effects on lymphatic tissue, occurring during the course of cirrhosis...
  66. ncbi Time-dependent aldosterone metabolism in toad urinary bladder
    A S Brem
    Division of Pediatric Nephrology, Rhode Island Hospital, Providence
    Am J Physiol 254:F547-53. 1988
    ..Both the generation of certain metabolites (e.g., 5 alpha-reductase pathway products) and the increase in Na+ transport can be selectively inhibited by K+-canrenoate...
  67. ncbi Antihypertensive effect of captopril, canrenoate potassium, and atenolol. Relations with red blood cell sodium transport and renin
    E Niutta
    Istituto di Scienze Mediche, Scuola di Specializzazione in Nefrologia, University of Milano, Italy
    Am J Hypertens 1:364-71. 1988
    We compared the antihypertensive efficacy of atenolol (100 mg/d), canrenoate potassium (200 mg/d), and captopril (75 mg/d) in 30 essential hypertensives...
  68. ncbi Comparative clinical study of spironolactone and potassium canrenoate. A randomized evaluation with double cross-over
    M Emili
    Department of Gastroenterology, University of Rome La Sapienza, Italy
    Arzneimittelforschung 38:1492-5. 1988
    ..abstract truncated at 250 words)..
  69. ncbi The antihypertensive and renal activities of potassium canrenoate are associated with increased renal prostaglandin excretion
    S Castellani
    Clinica Medica I, University of Florence, Italy
    Clin Sci (Lond) 77:217-22. 1989
    ....
  70. ncbi Canrenone and androgen receptor-active materials in plasma of cirrhotic patients during long-term K-canrenoate or spironolactone therapy
    A Andriulli
    Divisione di Gastroenterologia, Ospedale San Giovanni Battista Molinette, Torino, Italia
    Digestion 44:155-62. 1989
    ..The lower incidence of antiandrogenic or estrogen-like side effects during K-canrenoate seems to be related to metabolites other than canrenone itself...
  71. ncbi [Effect of potassium canrenoate on the EP and Na+, K+ activities in endolymph]
    S Wakizono
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University
    Nihon Jibiinkoka Gakkai Kaiho 93:373-80. 1990
    ..There are no pathological changes both in the TEM view of the stria vascularis and in the SEM view of the hair cell. These results suggest that this drug may affect K+ conductance of the stria vascularis specifically...
  72. ncbi The difference in endocochlear and endolymphatic sac d.c. potentials in response to furosemide and canrenoate as diuretics
    N Mori
    Department of Otolaryngology, Kagawa Medical School, Japan
    Eur Arch Otorhinolaryngol 247:371-3. 1990
    ..The differences in the EP and ESP in the response to the diuretics indicate a dissimilarity of the origin of both d.c. potentials in the endolymphatic space...
  73. ncbi Predicting interindividual variations in antihypertensive therapy: the role of sodium transport systems and renin
    E Niutta
    Istituto di Scienze Mediche, University of Milan, Italy
    J Hypertens Suppl 8:S53-8. 1990
    The efficacy of captopril at 75 mg/day, atenolol at 100 mg/day and canrenoate potassium at 200 mg/day was compared in 42 essential hypertensive patients in randomly assigned sequences...
  74. ncbi Influence of diuretics on brachial artery diameter and distensibility in hypertensive patients
    S Laurent
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Fundam Clin Pharmacol 4:685-93. 1990
    ..The study indicates that, in hypertensive patients of middle age, diuretics did not change brachial artery diameter and distensibility, whether the drug caused an increase or a decrease in plasma potassium levels...
  75. ncbi Ototoxic effect of potassium canrenoate on the guinea pig cochlea
    S Komune
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Acta Otolaryngol 111:719-27. 1991
    ..The potassium ion activity in the endolymph decreased slightly but the sodium ion activity remained unchanged during perfusion. These findings suggest that the main target of the PC is the cells of the stria vascularis...
  76. ncbi Rapid effects of mineralocorticoids on sodium-proton exchanger: genomic or nongenomic pathway?
    M Wehling
    Medizinische Klinik Innenstadt, University of Munich, Federal Republic of Germany
    Am J Physiol 260:E719-26. 1991
    ..These putative novel receptors may in turn bind novel aldosterone antagonists with possible diuretic and vasodilator effects distinct from those of spironolactones...
  77. ncbi [Effect of potassium canrenoate on serum magnesium levels after extracorporeal circulation]
    K Tsuji
    Second Department of Surgery, Okayama University School of Medicine
    Kokyu To Junkan 40:813-8. 1992
    ..05). These results suggested that administration of potassium canrenoate is useful for keeping and improving serum Mg levels after extracorporeal circulation...
  78. ncbi Torasemide in the treatment of patients with cirrhosis and ascites
    P Gentilini
    Istituto di Clinica Medica II, University of Florence School of Medicine, Italy
    Cardiovasc Drugs Ther 7:81-5. 1993
    ..The results of this study indicate that torasemide is suitable for the treatment of sodium retention in patients with cirrhosis and ascites...
  79. ncbi Regulation of renal hemodynamics after protein feeding: effects of proximal and distal diuretics
    L L Woods
    Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland 97201 3098
    Am J Physiol 264:R337-44. 1993
    ....
  80. ncbi Effects of canrenoate on red cell sodium transport and calf flow in essential hypertension
    A Semplicini
    Clinica Medica I, University of Padua, Italy
    Am J Hypertens 6:295-301. 1993
    ..None of these parameters changed significantly in the other patients. Thus these data suggest that the fall in vascular resistance induced by canrenoate is mediated, in part, by the antagonism of endogenous ouabain-like factors...
  81. ncbi Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels
    Ricardo Caballero
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Circulation 107:889-95. 2003
    ..In this study, the effects of SP and its metabolite, canrenoic acid (CA), on human ether-a-go-go-related gene (HERG) currents were analyzed...
  82. ncbi Bidirectional (positive/negative) interference of spironolactone, canrenone, and potassium canrenoate on serum digoxin measurement: elimination of interference by measuring free digoxin or using a chemiluminescent assay for digoxin
    Amitava Dasgupta
    Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Clin Lab Anal 16:172-7. 2002
    ..Another approach to avoid this interference is to use the CLIA digoxin assay...
  83. ncbi Mineralocorticoid receptor blockade by canrenoate increases both spontaneous and stimulated adrenal function in humans
    E Arvat
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:3176-81. 2001
    ..These results also suggest that the stimulatory effect of CAN on HPA axis is mediated by concomitant modulation of CRH and AVP release...
  84. ncbi Additional beneficial effects of canrenoate in patients with anterior myocardial infarction on ACE-inhibitor treatment. A pilot study
    P Di Pasquale
    Division of Cardiology Paolo Borsellino, G E Ingrassia Hospital, Palermo, Italy
    Ital Heart J 2:121-9. 2001
    ..Recent evidence suggests that, via the mineralocorticoid receptors present in cardiovascular tissues, aldosterone exerts profibrotic effects, and that partial aldosterone escape occurs during ACE-inhibitor treatment...
  85. ncbi The combination ace-inhibitors plus canreonate in patients with anterior myocardial infarction: safety and tolerability study
    P Di Pasquale
    Division of Cardiology, Paolo Borsellino, G F Ingrassia Hospital, Palermo, Italy
    Int J Cardiol 77:119-27; discussion 128-9. 2001
    ..There is recent evidence that aldosterone (ALDO) exerts pro-fibrotic effects, acting via the mineral-corticoid receptors in cardiovascular tissues and partial aldosterone escape during ACE-inhibition treatment occurs...
  86. ncbi Decreased vasopressin-mediated renal water reabsorption in rats with chronic aldosterone-receptor blockade
    T E Jonassen
    Department of Pharmacology, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Am J Physiol Renal Physiol 278:F246-56. 2000
    ..This strongly supports the view that aldosterone plays a significant role for vasopressin-mediated water reabsorption...
  87. ncbi Intralymphocyte free magnesium in patients with primary aldosteronism: aldosterone and lymphocyte magnesium homeostasis
    P Delva
    Departments of Biomedic and Surgical Sciences, University of Verona, Policlinico Borgo Roma, Verona, Italy
    Hypertension 35:113-7. 2000
    ..The data are consistent with the hypothesis that aldosterone affects the cellular homeostasis of magnesium, probably through modification of the activity of the Na(+)-Mg(2+) antiporter...
  88. ncbi Memory consolidation in human sleep depends on inhibition of glucocorticoid release
    W Plihal
    Georg Elias Müller Institute of Psychology, University of Gottingen, Germany
    Neuroreport 10:2741-7. 1999
    ..Blocking mineralocorticoid receptors by canrenoate did not affect memory, suggesting inactivation of glucocorticoid receptors to be the essential prerequisite for memory consolidation during early sleep...
  89. ncbi Aldosterone metabolism in cultures of rat renal cortical and medullary cells
    M Egfjord
    Medical Department P, Rigshospitalet, Copenhagen, Denmark
    Scand J Clin Lab Invest 59:107-13. 1999
    ..This indicated that the metabolism might play some role in modulation of the intracellular response to aldosterone in the kidney...
  90. ncbi Different sensitivity to hydrochlorothiazide and to potassium-canrenoate among essential hypertensive patients
    N Glorioso
    Hypertension Center, University of Sassari, Viale S Pietro, Italy
    Clin Exp Hypertens 15:187-96. 1993
    ..Their selective response to K-Can suggest a peculiar pathogenetic mechanism underlying their high blood pressure...
  91. ncbi Increase in the basal tone of guinea pig thoracic aorta induced by ouabain is inhibited by spironolactone canrenone and potassium canrenoate
    R Sorrentino
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    J Cardiovasc Pharmacol 28:519-25. 1996
    ..Our results may indicate that spironolactone, canrenone, and potassium canrenoate act in hypertension by interfering with mechanisms in which an ouabain-like factor is involved...
  92. ncbi Blocking of central nervous mineralocorticoid receptors counteracts inhibition of pituitary-adrenal activity in human sleep
    J Born
    Department of Internal Medicine, University of Lubeck, Germany
    J Clin Endocrinol Metab 82:1106-10. 1997
    ..The inhibition disappearance after blockage of MR suggests that sleep exerts this influence via central nervous MR-expressing cells. These cells seem to be simultaneously involved in the generation of slow-wave sleep...
  93. ncbi Cross-reactivity of TDX and OPUS immunoassay systems for serum digoxin determination
    M Okazaki
    Department of Hospital Pharmacy, School of Medicine, Kobe University, Japan
    Ther Drug Monit 19:657-62. 1997
    ..The authors found OPUS more useful for monitoring serum digoxin concentrations in patients because of its superior specificity...
  94. ncbi Inhibitory effect of aldosterone on the natriuretic response to atrial natriuretic peptide in hypocapnic rats
    H Kanauchi
    Department of Surgery, University of Tokyo, Japan
    Clin Exp Pharmacol Physiol 25:607-11. 1998
    ..The data suggest that aldosterone plays an important role by limiting the renal actions of ANP during acute hypocapnia...
  95. ncbi Aldosterone receptor blockade inhibits increased furosemide-sensitive sodium reabsorption in rats with liver cirrhosis
    T E Jonassen
    Department of Pharmacology, the Panu Institute, University of Copenhagen, Denmark
    J Pharmacol Exp Ther 287:931-6. 1998
    ..These data suggest that chronic aldosterone receptor blockade with canrenoate prevents sodium retention in cirrhotic rats partly by inhibition of increased sodium reabsorption in the thick ascending limb...
  96. ncbi Albumin improves the response to diuretics in patients with cirrhosis and ascites: results of a randomized, controlled trial
    P Gentilini
    Institute of Internal Medicine, University of Florence School of Medicine, Italy
    J Hepatol 30:639-45. 1999
    ..We investigated whether intravascular volume expansion with albumin exert beneficial effects in cirrhosis with ascites...
  97. ncbi Rationale for an early aldosterone blockade in acute myocardial infarction and design of the ALBATROSS trial
    Farzin Beygui
    Institut de Cardiologie and INSERM U937, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Am Heart J 160:642-8. 2010
    ..Angiotensin-converting enzyme inhibitors have delayed partial and temporary effects on aldosterone levels. We hypothesize that aldosterone receptor blockade, early after AMI onset on top of standard therapy, may improve clinical outcome...
  98. ncbi Aldosterone blockade in patients with acute myocardial infarction
    Henry A Solomon
    Circulation 108:E173; author reply E173. 2003
  99. ncbi Antimineralocorticoid canrenoate enhances secretory activity of the hypothalamus-pituitary-adrenocortical (HPA) axis in humans
    C Dodt
    Department of Internal Medicine, Medical University of Lubeck, FRG
    Neuroendocrinology 58:570-4. 1993
    ..05). Changes induced by canrenoate paralleling those in animals after intracerebroventricular administration of MR antagonists suggest that central nervous MRs are involved in the regulation of HPA secretory activity also in humans...
  100. ncbi Vasopressin and angiotensin II in the conscious dog: synergistic effects on renal excretory parameters?
    P Eiken
    Department of Medical Physiology C, Panum Institute, University of Copenhagen, Denmark
    Clin Sci (Lond) 83:467-75. 1992
    ..Vasopressin alone exerted its antidiuretic effect without affecting plasma renin activity, plasma aldosterone concentration or renal excretion of Na+ and K+.(ABSTRACT TRUNCATED AT 250 WORDS)..
  101. ncbi The stimulatory effect of canrenoate, a mineralocorticoid antagonist, on the activity of the hypothalamus-pituitary-adrenal axis is abolished by alprazolam, a benzodiazepine, in humans
    S Grottoli
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 87:4616-20. 2002
    ..These findings emphasize the role of GABA in the control of the HPA axis in humans...