dehydroepiandrosterone

Summary

Summary: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.

Top Publications

  1. ncbi Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women
    Anne M Kenny
    Center on Aging, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Am Geriatr Soc 58:1707-14. 2010
  2. ncbi Dehydroepiandrosterone (DHEA)--a precursor steroid or an active hormone in human physiology
    Abdulmaged M Traish
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    J Sex Med 8:2960-82; quiz 2983. 2011
  3. pmc Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function
    David Barad
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    J Assist Reprod Genet 24:629-34. 2007
  4. pmc Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR)
    Norbert Gleicher
    Center for Human Reproduction CHR and Foundation for Reproductive Medicine, New York, NY, USA
    Reprod Biol Endocrinol 9:67. 2011
  5. pmc Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)
    Nicole Maninger
    Department of Psychiatry, University of California San Francisco, School of Medicine, San Francisco 94143, USA
    Front Neuroendocrinol 30:65-91. 2009
  6. ncbi Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients
    Linda E Carlson
    Department of Psychosocial Resources, Tom Baker Cancer Centre, Alberta Cancer Board, 1331 29 Street NW, Calgary, Alta, Canada T2N 4N2
    Psychoneuroendocrinology 29:448-74. 2004
  7. ncbi Adrenarche in comparative perspective
    Benjamin Campbell
    Department of Anthropology, University of Wisconsin Milwaukee, 53211, USA
    Am J Hum Biol 23:44-52. 2011
  8. ncbi Dehydroepiandrosterone inhibits the activation and dysfunction of endothelial cells induced by high glucose concentration
    Elizabeth Huerta-García
    Departamento de Biologia Celular, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico DF, Mexico
    Steroids 77:233-40. 2012
  9. ncbi Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, Rockville, MD 20892 1276, USA
    Arch Gen Psychiatry 62:154-62. 2005
  10. pmc Dehydroepiandrosterone protects against oxidative stress-induced endothelial dysfunction in ovariectomized rats
    João Paulo Gabriel Camporez
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S ao Paulo, SP, Brazil
    J Physiol 589:2585-96. 2011

Detail Information

Publications370 found, 100 shown here

  1. ncbi Dehydroepiandrosterone combined with exercise improves muscle strength and physical function in frail older women
    Anne M Kenny
    Center on Aging, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Am Geriatr Soc 58:1707-14. 2010
    To investigate the effects of dehydroepiandrosterone (DHEA) combined with exercise on bone mass, strength, and physical function in older, frail women.
  2. ncbi Dehydroepiandrosterone (DHEA)--a precursor steroid or an active hormone in human physiology
    Abdulmaged M Traish
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    J Sex Med 8:2960-82; quiz 2983. 2011
    The circulation of large amounts of dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEA-S) suggests a physiological role in human physiology...
  3. pmc Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function
    David Barad
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    J Assist Reprod Genet 24:629-34. 2007
    ..We assessed the role of DHEA supplementation on pregnancy rates in women with diminished ovarian function...
  4. pmc Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR)
    Norbert Gleicher
    Center for Human Reproduction CHR and Foundation for Reproductive Medicine, New York, NY, USA
    Reprod Biol Endocrinol 9:67. 2011
    ..b>Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances with DOR, and is now utilized by approximately one ..
  5. pmc Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)
    Nicole Maninger
    Department of Psychiatry, University of California San Francisco, School of Medicine, San Francisco 94143, USA
    Front Neuroendocrinol 30:65-91. 2009
    ..Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed...
  6. ncbi Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients
    Linda E Carlson
    Department of Psychosocial Resources, Tom Baker Cancer Centre, Alberta Cancer Board, 1331 29 Street NW, Calgary, Alta, Canada T2N 4N2
    Psychoneuroendocrinology 29:448-74. 2004
    ..a mindfulness-based stress reduction meditation program for early stage breast and prostate cancer patients and quality of life, mood states, stress symptoms, and levels of cortisol, dehydroepiandrosterone-sulfate (DHEAS) and melatonin.
  7. ncbi Adrenarche in comparative perspective
    Benjamin Campbell
    Department of Anthropology, University of Wisconsin Milwaukee, 53211, USA
    Am J Hum Biol 23:44-52. 2011
    ..To addresses the hypothesis that human adrenarche is associated with extended juvenile brain development by comparing the timing of adrenal androgen production, brain development and lactation in a larger comparative mammalian context...
  8. ncbi Dehydroepiandrosterone inhibits the activation and dysfunction of endothelial cells induced by high glucose concentration
    Elizabeth Huerta-García
    Departamento de Biologia Celular, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico DF, Mexico
    Steroids 77:233-40. 2012
    b>Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes; however, its mechanisms of action are unknown...
  9. ncbi Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression
    Peter J Schmidt
    Behavioral Endocrinology Branch, National Institute of Mental Health, Rockville, MD 20892 1276, USA
    Arch Gen Psychiatry 62:154-62. 2005
    ..The adrenal androgen and neurosteroid dehydroepiandrosterone (DHEA) is available as over-the-counter hormonal therapy and previously has been reported to have ..
  10. pmc Dehydroepiandrosterone protects against oxidative stress-induced endothelial dysfunction in ovariectomized rats
    João Paulo Gabriel Camporez
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S ao Paulo, SP, Brazil
    J Physiol 589:2585-96. 2011
    ..Moreover, the marked age-related decline in serum dehydroepiandrosterone (DHEA) level has been associated to cardiovascular disease...
  11. ncbi Dehydroepiandrosterone replacement in women with adrenal insufficiency
    W Arlt
    Department of Endocrinology, Medical University Hospital, Wuerzburg, Germany
    N Engl J Med 341:1013-20. 1999
    The physiologic role of dehydroepiandrosterone in humans is still unclear...
  12. ncbi Increased oocyte production after treatment with dehydroepiandrosterone
    David H Barad
    Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, New York, New York, USA
    Fertil Steril 84:756. 2005
    To describe a case of dramatically improved ovarian reserve in a 42.7-year-old woman who was using the dietary supplement dehydroepiandrosterone (DHEA) as well as acupuncture.
  13. pmc Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization (IVF) pregnancy rates in women with diminished ovarian reserve (DOR)
    Norbert Gleicher
    Center for Human Reproduction, New York, NY 10021, USA
    J Assist Reprod Genet 30:49-62. 2013
    To investigate whether androgen conversion rates after supplementation with dehydroepiandrosterone (DHEA) differ, and whether differences between patients with diminished ovarian reserve (DOR) are predictive of pregnancy chances in ..
  14. pmc Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis
    Amarin Narkwichean
    Division of Obstetrics and Gynaecology, School of Clinical Sciences, University of Nottingham, Nottingham, UK
    Reprod Biol Endocrinol 11:44. 2013
    ..It has been proposed that pre-IVF Dehydroepiandrosterone (DHEA) adjuvant therapy may improve ovarian response and pregnancy rates in women with diminished ovarian ..
  15. ncbi Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series
    P R Casson
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Baylor College of Medicine, 6550 Fannin, Suite 801, Houston, Texas 77030, USA
    Hum Reprod 15:2129-32. 2000
    ..We postulated that dehydroepiandrosterone (DHEA) administration to poor responders would augment gonado-trophin effect via a similar mechanism...
  16. ncbi Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome
    A B Motta
    Laboratorio de Fisio patología Ovárica, Centro de Estudios Farmacologicos y Botanicos CEFYBO, Facultad de Medicina, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Paraguay 2155, 1121 Buenos Aires, Argentina
    J Steroid Biochem Mol Biol 119:105-11. 2010
    ..Since dehydroepiandrosterone (DHEA) was found to be one of the most abundant circulating androgens in women with PCOS, a rodent model ..
  17. ncbi DHEA supplementation may improve IVF outcome in poor responders: a proposed mechanism
    Jordana H Hyman
    IVF Unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem 91031, Israel
    Eur J Obstet Gynecol Reprod Biol 168:49-53. 2013
    b>Dehydroepiandrosterone (DHEA) supplementation for poor responders may improve ovarian response and IVF treatment outcome...
  18. ncbi Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone
    Atsushi Mizokami
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Takaramachi, Kanazawa City, Japan
    Endocr Relat Cancer 16:1139-55. 2009
    ..In the present study, we investigated how stromal cells affect adrenal androgen dehydroepiandrosterone (DHEA) metabolism in androgen-sensitive PCa LNCaP cells...
  19. ncbi Deficiencies in circulating testosterone and dehydroepiandrosterone sulphate, and depression in men with systolic chronic heart failure
    Ewa A Jankowska
    Department of Heart Diseases, Faculty of Health Sciences, Wroclaw Medical University Military Hospital, Wroclaw, Poland
    Eur J Heart Fail 12:966-73. 2010
    ..Elderly men with androgen deficiencies are prone to develop late-onset depression. We investigated links between circulating androgens and depression, and their combined impact on outcome in men with chronic heart failure (CHF)...
  20. ncbi Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis
    Sebastien Bonnet
    Centre de recherche de L Hôtel Dieu de Québec, 9 rue McMahon, Quebec, QC, G1R 2J6, Canada
    Circulation 120:1231-40. 2009
    ..b>Dehydroepiandrosterone (DHEA) is a naturally occurring and clinically used steroid known to inhibit the Akt axis in cancer...
  21. pmc Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS)
    Norbert Gleicher
    Center for Human Reproduction CHR New York, NY, USA
    Reprod Biol Endocrinol 8:140. 2010
    b>Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy chances in women with diminished ovarian reserve (DOR), and to reduce miscarriage rates by 50-80%...
  22. pmc Miscarriage rates after dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve: a case control study
    Norbert Gleicher
    The Center for Human Reproduction New York, Foundation for Reproductive Medicine, New York, NY, USA
    Reprod Biol Endocrinol 7:108. 2009
    ..Since a large majority of spontaneous miscarriages are associated with aneuploidy, one can speculate that DHEA supplementation may also reduce miscarriage rates...
  23. ncbi Improvement in diminished ovarian reserve after dehydroepiandrosterone supplementation
    Norbert Gleicher
    Center for Human Reproduction, New York and Foundation for Reproductive Medicine, New York, NY, USA
    Reprod Biomed Online 21:360-5. 2010
    b>Dehydroepiandrosterone (DHEA) has been reported to improve oocyte/embryo yields and oocyte/embryo quality in women with diminished ovarian reserve. Whether DHEA objectively improves ovarian reserve is, however, unknown...
  24. ncbi Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF
    David Barad
    Center for Human Reproduction, New York, NY, USA
    Hum Reprod 21:2845-9. 2006
    The aim of this study was to investigate the effect of treatment with dehydroepiandrosterone (DHEA) on fertility outcomes among women with diminished ovarian reserve.
  25. ncbi Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane
    Sebastio Perrini
    Department of Emergency and Organ Transplantation, Section on Internal Medicine, Endocrinology and Metabolic Diseases, Bari, Italy
    Diabetes 53:41-52. 2004
    b>Dehydroepiandrosterone (DHEA) has been shown to modulate glucose utilization in humans and animals, but the mechanisms of DHEA action have not been clarified...
  26. ncbi Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study
    A Wiser
    IVF Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel
    Hum Reprod 25:2496-500. 2010
    The aim of this study was to evaluate the effect of dehydroepiandrosterone (DHEA) supplementation on in vitro fertilization (IVF) data and outcomes among poor-responder patients.
  27. ncbi Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock
    Wiebke Arlt
    Medical Research Council Senior Clinical Fellow, Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Room 233, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:2548-54. 2006
    b>Dehydroepiandrosterone (DHEA) replacement in sepsis has been advocated because of the sepsis-associated decrease in serum DHEA sulfate (DHEAS)...
  28. ncbi Dissecting human adrenal androgen production
    William E Rainey
    Department Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9032, USA
    Trends Endocrinol Metab 13:234-9. 2002
    The human adrenal cortex produces aldosterone, cortisol and the so-called adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)...
  29. ncbi DHEA in elderly women and DHEA or testosterone in elderly men
    K Sreekumaran Nair
    Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 355:1647-59. 2006
    b>Dehydroepiandrosterone (DHEA) and testosterone are widely promoted as antiaging supplements, but the long-term benefits, as compared with potential harm, are unknown.
  30. pmc Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue
    E E Baulieu
    Institut National de la Santé et de la Recherche Médicale Unit 488 and Collège de France, 94276 Le Kremlin Bicetre, France
    Proc Natl Acad Sci U S A 97:4279-84. 2000
    The secretion and the blood levels of the adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decrease profoundly with age, and the question is posed whether administration of the steroid to compensate for the ..
  31. pmc A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats
    Min Lu
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0673, USA
    Am J Physiol Endocrinol Metab 298:E1036-48. 2010
    ..Accordingly, HE3286 treatment markedly decreased total serum cholesterol. In conclusion, HE3286 is a novel anti-inflammatory compound, which displays both glucose-lowering and cholesterol-lowering effects...
  32. ncbi Adrenal androgens and intracrinology
    Fernand Labrie
    Oncology and Molecular Endocrinology Research Center, Laval University Hospital Research Center, Quebec City, Canada
    Semin Reprod Med 22:299-309. 2004
    ..all androgens are made locally in peripheral target tissues from the inactive adrenal steroid precursor dehydroepiandrosterone (DHEA). In adult men, approximated 50% of androgens are made locally...
  33. ncbi Dehydroepiandrosterone during sepsis: does the timing of administration influence the effectiveness
    Daniel Schmitz
    Department of Trauma Surgery, University Hospital of Essen, Essen, Germany
    J Surg Res 163:e73-7. 2010
    Administration of dehydroepiandrosterone (DHEA) has been demonstrated to improve survival and cellular immune functions during systemic inflammation...
  34. ncbi Serum concentrations of dehydroepiandrosterone and dehydroepiandrosterone sulfate and their relation to cytokine production during and after normal pregnancy
    Noriko Tagawa
    Clinical Chemistry Laboratory, Kobe Pharmaceutical University, 658 8558 Kobe, Japan
    Clin Chim Acta 340:187-93. 2004
    Since dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) have been suggested to have immunoregulatory effects, changes in the levels of these substances during and after pregnancy might affect the maternal immune ..
  35. ncbi Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone
    Lamia Azzi
    Oncology and Molecular Endocrinology Research Center, CHUL Research Center and Laval University, Quebec City, QC, Canada
    J Invest Dermatol 124:22-7. 2005
    ..in GDX animals treated for 3 wk with 17beta-estradiol (E2), dihydrotestosterone (DHT), or their precursor dehydroepiandrosterone (DHEA)...
  36. pmc Is there a role for DHEA supplementation in women with diminished ovarian reserve?
    Mazen R Fouany
    Department of Obstetrics and Gynecology, Charles Cole Memorial Hospital, Coudersport, PA, USA
    J Assist Reprod Genet 30:1239-44. 2013
    Poor ovarian reserve and poor ovarian response presents a challenge to IVF centers. Dehydroepiandrosterone (DHEA) supplementation is increasingly being used by many IVF centers around the world in poor responders despite the lack of ..
  37. ncbi Inactivating PAPSS2 mutations in a patient with premature pubarche
    Cees Noordam
    Department of Pediatrics Metabolic and Endocrine Disorders, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 360:2310-8. 2009
    b>Dehydroepiandrosterone (DHEA) sulfotransferase, known as SULT2A1, converts the androgen precursor DHEA to its inactive sulfate ester, DHEAS [corrected], thereby preventing the conversion of DHEA to an active androgen...
  38. ncbi Analysis of neurosteroid levels in attention deficit hyperactivity disorder
    R D Strous
    Beer Yaakov Mental Health Center, PO Box 1, Beer Yaakov 70350, Israel
    Int J Neuropsychopharmacol 4:259-64. 2001
    ..We examined the relationship between blood levels of dehydroepiandrosterone (DHEA), its principal precursor pregnenolone and its principal metabolite dehydroepiandrosterone sulphate (..
  39. ncbi Effect of androgen supplementation or modulation on ovarian stimulation outcome in poor responders: a meta-analysis
    Sesh Kamal Sunkara
    Assisted Conception Unit, Guy s Hospital, St Thomas Street, London, UK
    Reprod Biomed Online 22:545-55. 2011
    ..There is currently insufficient evidence from the few randomized controlled trials to support the use of androgen supplementation or modulation to improve live birth outcome in poor responders undergoing IVF/ICSI treatment...
  40. ncbi Effects of prolonged stress on salivary cortisol and dehydroepiandrosterone: a study of a two-week teaching practice
    Shuhei Izawa
    Health Administration and Psychosocial Factor Research Group, National Institute of Occupational Safety and Health JAPAN, Kanagawa, Japan
    Psychoneuroendocrinology 37:852-8. 2012
    This study investigated variations in salivary levels of cortisol and dehydroepiandrosterone (DHEA) in a prolonged stressful situation (a two-week teaching practice)...
  41. ncbi Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway
    Hong Zhi Sun
    Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, School of Medicine, Xi an Jiaotong University, Xi an, People s Republic of China
    J Endocrinol 204:311-8. 2010
    b>Dehydroepiandrosterone (DHEA) is an endogenous steroid that is metabolized to androgens and/or estrogens in the human prostate...
  42. pmc Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1
    Edugie J Ekuase
    Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, United States
    Chem Res Toxicol 24:1720-8. 2011
    ..A total of 15 OHPCBs were examined, and the sulfation of 1 μM [(3)H] dehydroepiandrosterone (DHEA) was utilized as a model reaction catalyzed by the enzyme...
  43. ncbi Dehydroepiandrosterone reduces preadipocyte proliferation via androgen receptor
    Kei Fujioka
    Dept of General Internal Medicine, Gifu Univ Graduate School of Medicine, Yanagido, Gifu, Japan
    Am J Physiol Endocrinol Metab 302:E694-704. 2012
    Several studies have suggested that both testosterone and dehydroepiandrosterone (DHEA) have weight-reducing and antidiabetic effects, especially in rodent studies; however, the precise mechanism of their action remains unclear...
  44. ncbi Dehydroepiandrosterone inhibits the Src/STAT3 constitutive activation in pulmonary arterial hypertension
    Roxane Paulin
    Department of Medicine, Laval University, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Hotel Dieu de Quebec, Quebec City, Quebec, Canada
    Am J Physiol Heart Circ Physiol 301:H1798-809. 2011
    ..b>Dehydroepiandrosterone (DHEA) is a steroid hormone shown to reverse vascular remodeling in systemic vessels...
  45. ncbi Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats
    Manuela Aragno
    Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Turin 10126, Italy
    Endocrinology 143:3250-8. 2002
    ..b>Dehydroepiandrosterone, an adrenal steroid, which possesses a multitargeted antioxidant effects, is also synthesized de novo by ..
  46. ncbi Antiviral effect of dehydroepiandrosterone on Japanese encephalitis virus infection
    Chia Che Chang
    Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan
    J Gen Virol 86:2513-23. 2005
    ..b>Dehydroepiandrosterone (DHEA), an adrenal-derived steroid, has been implicated in protection against neurotoxicity and protection ..
  47. ncbi Adrenarche and middle childhood
    Benjamin C Campbell
    Department of Anthropology, University of Wisconsin Milwaukee, 290 Sabin Hall, 3413 N Downer Ave, Milwaukee, WI 53211, USA
    Hum Nat 22:327-49. 2011
    ..of anatomical structures for subsistence, and endocrinologically by adrenarche, the adrenal production of dehydroepiandrosterone (DHEA)...
  48. pmc Effects of cigarette smoking, metabolic syndrome and dehydroepiandrosterone deficiency on intima-media thickness and endothelial function in hypertensive postmenopausal women
    Jolanta Mieczkowska
    Department of Internal Medicine, Medical University of Lublin, Lublin, Poland
    Med Sci Monit 18:CR225-34. 2012
    ..The aim of this study was to assess the relationship between smoking and arterial hypertension as well as endothelial dysfunction in postmenopausal women without clinically manifested symptoms of atherosclerosis...
  49. ncbi The impact of androgen metabolism and FMR1 genotypes on pregnancy potential in women with dehydroepiandrosterone (DHEA) supplementation
    Andrea Weghofer
    Department of Obstetrics and Gynecology, Medical University Vienna, Waehringer Guertel 18 20, Vienna A 1090, Austria
    Hum Reprod 27:3287-93. 2012
    ....
  50. ncbi Dehydroepiandrosterone: a modulator of cellular immunity and heat shock protein 70 production during polymicrobial sepsis
    Reiner Oberbeck
    Department of Trauma Surgery, University Hospital of Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Intensive Care Med 33:2207-13. 2007
    ..We investigated the effect of DHEA administration on survival, cellular immune functions, and HSP-70 production in septic mice...
  51. pmc 16alpha-bromoepiandrosterone, an antimalarial analogue of the hormone dehydroepiandrosterone, enhances phagocytosis of ring stage parasitized erythrocytes: a novel mechanism for antimalarial activity
    Kodjo Ayi
    Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
    Antimicrob Agents Chemother 46:3180-4. 2002
    b>Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S), which are the most abundant hormones secreted by the adrenal cortex and are present in plasma at approximately 6 micro M, as well as their analogue, 16alpha-bromoepiandrosterone (..
  52. ncbi Salivary dehydroepiandrosterone, but not cortisol, is associated with attention deficit hyperactivity disorder
    Liang Jen Wang
    Department of Psychiatry, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan
    World J Biol Psychiatry 12:99-109. 2011
    The purposes of this study were to determine whether salivary levels of dehydroepiandrosterone (DHEA) and cortisol are associated with attention deficit hyperactivity disorder (ADHD) or correlated with performance on the Continuous ..
  53. ncbi Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cells
    Ling Wang
    Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, China
    Atherosclerosis 214:47-57. 2011
    The risk for atherosclerosis is increased in postmenopausal women. Dehydroepiandrosterone (DHEA) is postulated to have anti-atherogenic properties, but the mechanism remains unclear...
  54. ncbi Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging
    M Vallee
    Institut F Magendie INSERM U259, Domaine de Carreire, rue Camille Saint Saens, 33077, Cedex, Bordeaux, France
    Brain Res Brain Res Rev 37:301-12. 2001
    ..Studies in animals demonstrated that the neurosteroids pregnenolone (PREG) and dehydroepiandrosterone (DHEA), as sulfate derivatives (PREGS and DHEAS, respectively), display memory-enhancing properties in ..
  55. pmc Feasibility of a liver transcriptomics approach to assess bovine treatment with the prohormone dehydroepiandrosterone (DHEA)
    Jeroen C W Rijk
    RIKILT Institute of Food Safety, Wageningen UR, PO Box 230, 6700 AE Wageningen, The Netherlands
    BMC Vet Res 6:44. 2010
    ..Illegal use of natural prohormones like dehydroepiandrosterone (DHEA) is hard to prove since prohormones are strongly metabolized in vivo...
  56. ncbi Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin
    Mi Hee Shin
    Department of Dermatology, Seoul National University College of Medicine and Laboratory of Cutaneous Aging Research, Clinical Research Institute, Seoul National University Hospital, 28 Yungon Dong, Chongno Gu, Seoul 110 744, Korea
    J Invest Dermatol 124:315-23. 2005
    b>Dehydroepiandrosterone (DHEA) and its sulfate conjugate (DHEA-S) are the most abundantly produced human adrenal steroids to be reduced with age...
  57. ncbi Research on the age-related changes in the nitric oxide pathway in the arteries of rats and the intervention effect of dehydroepiandrosterone
    Saizhu Wu
    Department of Cardiology, Nanfang Hospital, Guangzhou, China
    Gerontology 53:234-7. 2007
    ..However, the cellular and molecular pathologic mechanisms underlying the aging of blood vessels remain unclear...
  58. ncbi Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1
    Caroline Muller
    Laboratoire de Biologie, EA 3199, Conservatoire National des Arts et Metiers, 2 rue Conté, 75003 Paris, France
    J Steroid Biochem Mol Biol 99:215-22. 2006
    The dehydroepiandrosterone (DHEA) 7alpha-hydroxylation in humans takes place in the liver, skin, and brain...
  59. ncbi Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice
    Shigeki Moriguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aramaki aoba, Sendai, Japan
    J Neurochem 117:879-91. 2011
    b>Dehydroepiandrosterone (DHEA) is one of the most abundant neurosteroids synthesized de novo in the CNS...
  60. ncbi Wide distribution of the serum dehydroepiandrosterone and sex steroid levels in postmenopausal women: role of the ovary?
    Fernand Labrie
    EndoCeutics Inc, Quebec City, Quebec, Canada
    Menopause 18:30-43. 2011
    Because the exclusive source of sex steroids (at least estrogens) after menopause is recognized to be dehydroepiandrosterone (DHEA), this study examines the interindividual variability of serum DHEA and its metabolites as well as the ..
  61. ncbi Genetic susceptibility for C19 androgen induction of ovarian granulosa cell tumorigenesis in SWXJ strains of mice
    B J Tennent
    Jackson Laboratory, Bar Harbor, Maine 04609
    Cancer Res 53:1059-63. 1993
    ..occur spontaneously (spontaneous strains), and in others GC tumors can only be induced by treatment with dehydroepiandrosterone (DHEA-dependent strains)...
  62. ncbi Dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol concentrations in intensive care unit patients
    M M Folan
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Crit Care Med 29:965-70. 2001
    ..updated Acute Physiology and Chronic Health Evaluation) score, is correlated with early morning cortisol, dehydroepiandrosterone (DHEA), and/or dehydroepiandrosterone-sulfate (DHEA-S) concentrations...
  63. ncbi Ongoing pregnancies from early retrieval of prematurely developing antral follicles after DHEA supplementation
    Murat Sonmezer
    Ankara University School of Medicine, Department of Obstetrics and Gynecology, Turkey
    Reprod Biomed Online 19:816-9. 2009
    ..aggressive ovarian stimulation conceived with oocytes from prematurely developing antral follicles after dehydroepiandrosterone supplementation. The first patient had 11 and 14...
  64. ncbi Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial
    Michael S Ritsner
    Department of Psychiatry, The Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Clin Psychiatry 71:1351-62. 2010
    Pregnenolone (PREG) and dehydroepiandrosterone (DHEA) are reported to have a modulatory effect on neuronal excitability, synaptic plasticity, and response to stress; they are associated with mood regulation and cognitive performance...
  65. ncbi Bacteria in the oral mucosa and its effects on the measurement of cortisol, dehydroepiandrosterone, and testosterone in saliva
    Guy Lucien S Whembolua
    Behavioral Endocrinology Laboratory, Department of Biobehavioral Health, 315 Health and Human Development East, The Pennsylvania State University, University Park, 16802, USA
    Horm Behav 49:478-83. 2006
    ..was experimentally manipulated, and the consequences for the measurement of salivary testosterone (T), dehydroepiandrosterone (DHEA), and cortisol (C) were examined...
  66. ncbi Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity
    JUANA SANCHEZ
    Laboratory of Molecular Biology, Nutrition and Biotechnology Nutrigenomics, University of the Balearic Islands, CIBER Fisiopatología Obesidad y Nutrición CB06 03, Instituto de Salud Carlos III, 07122 Palma de Mallorca, Spain
    J Nutr Biochem 19:809-18. 2008
    ....
  67. ncbi Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450
    Kristy K Michael Miller
    Department of Biochemistry and Molecular Biology, The University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Drug Metab Dispos 32:305-13. 2004
    The purpose of this study was to quantify the oxidative metabolism of dehydroepiandrosterone (3beta-hydroxy-androst-5-ene-17-one; DHEA) by liver microsomal fractions from various species and identify the cytochrome P450 (P450) enzymes ..
  68. ncbi Dehydroepiandrosterone: A new treatment for vascular remodeling diseases including pulmonary arterial hypertension
    Eric Dumas De La Roque
    Réanimation néonatale, Hôpital Pellegrin Enfants, CHU Bordeaux Place Amèlie Raba Lèon, 33076 Bordeaux, France
    Pharmacol Ther 126:186-99. 2010
    This review describes the cellular and molecular mechanism heterogeneity of dehydroepiandrosterone (DHEA) and its putative therapeutic role in vascular remodeling diseases such as pulmonary artery hypertension (PAH)...
  69. ncbi Demethylation of LHR in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome
    Jia Qiao Zhu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Datun Rd, Chaoyang, Beijing 100101, China
    Mol Hum Reprod 16:260-6. 2010
    ..and bisulfite restriction analysis to investigate the DNA methylation status of LHR, AR, FSHR and H19 in dehydroepiandrosterone (DHEA)-induced mouse PCOS model...
  70. ncbi Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women
    A Lasco
    Department of Internal Medicine, University of Messina, Messina, Italy
    Eur J Endocrinol 145:457-61. 2001
    To investigate whether long-term treatment with dehydroepiandrosterone (DHEA) in postmenopausal women can modify insulin sensitivity and plasma lipid profile.
  71. ncbi The estrogen antagonist EM-652 and dehydroepiandrosterone prevent diet- and ovariectomy-induced obesity
    Christian Lemieux
    Centre de Recherche de l Hôpital Laval and Département d Anatomie et Physiologie, Faculte de Medecine, Universite Laval, Quebec, Canada
    Obes Res 11:477-90. 2003
    ..This study aimed to assess the ability of EM-652, alone or with dehydroepiandrosterone (DHEA), to prevent obesity and related metabolic abnormalities induced by an obesity-promoting diet and ..
  72. ncbi Premature ovarian failure and dehydroepiandrosterone
    Leonidas Mamas
    Neogenesis IVF Centre, Athens, Greece
    Fertil Steril 91:644-6. 2009
    ....
  73. ncbi Neurosteroids as modulators of neurogenesis and neuronal survival
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion 71003, Greece
    Trends Endocrinol Metab 19:300-7. 2008
    ..This review summarizes the recent findings on how the most studied neurosteroids (dehydroepiandrosterone, pregnenolone and their sulphate esters, progesterone and allopregnanolone) affect neuronal survival, ..
  74. pmc Effects of dehydroepiandrosterone on Th2 cytokine production in peripheral blood mononuclear cells from asthmatics
    Inseon S Choi
    Department of Allergy, Chonnam National University Medical School, Gwangju, Korea
    Korean J Intern Med 23:176-81. 2008
    The androgen dehydroepiandrosterone (DHEA) attenuates allergic inflammatory airway reactions by down-regulating the Th2 response in mice...
  75. ncbi Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence
    R H Straub
    Department of Internal Medicine I, University Medical Center, Regensburg, Germany
    J Clin Endocrinol Metab 83:2012-7. 1998
    ..In these diseases or during aging, the decrease in production of sex hormones such as dehydroepiandrosterone (DHEA) is thought to play an important role in IL-6-mediated pathogenetic effects in mice...
  76. ncbi Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor
    Dongmin Liu
    Division of Endocrinology, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52246, USA
    Steroids 69:279-89. 2004
    b>Dehydroepiandrosterone (DHEA) improves vascular function, but the mechanism of this effect is unclear...
  77. ncbi Dehydroepiandrosterone supplementation improves ovarian response and cycle outcome in poor responders
    M Sonmezer
    Ankara University School of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey
    Reprod Biomed Online 19:508-13. 2009
    The effect of dehydroepiandrosterone (DHEA) supplementation on cycle outcome was assessed in patients with poor ovarian response...
  78. ncbi Effects of dehydroepiandrosterone on ovarian cystogenesis and immune function
    Carolina Griselda Luchetti
    Laboratorio de Fisiopatología Ovárica, Centro de Estudios Farmacologicos y Botanicos CEFYBO, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Serrano 669, C1414DEM Buenos Aires, Argentina
    J Reprod Immunol 64:59-74. 2004
    ..between ovarian functionality and the immune response during cystogenesis induced by androgenization with dehydroepiandrosterone (DHEA)...
  79. pmc Salivary cortisol and DHEA levels in the Korean population: age-related differences, diurnal rhythm, and correlations with serum levels
    Ryun Sup Ahn
    Graduate School of Complementary and Alternative Medicine, Pochon CHA Medical University, 605 Yuksam dong, Kangnam Gu, Seoul 135 913, Korea
    Yonsei Med J 48:379-88. 2007
    ..The secondary objective was to obtain a standard diurnal rhythm of salivary cortisol and DHEA in the Korean population...
  80. ncbi Amelioration of glucose intolerance by the synthetic androstene HE3286: link to inflammatory pathways
    Tianlun Wang
    Hollis Eden Pharmaceuticals, Inc, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 333:70-80. 2010
    ....
  81. ncbi Is dehydroepiandrosterone a hormone?
    F Labrie
    Laboratory of Molecular Endocrinology and Oncology, Laval University Hospital Research Center CRCHUL and Laval University, Quebec City, Quebec G1V4G2, Canada
    J Endocrinol 187:169-96. 2005
    b>Dehydroepiandrosterone (DHEA) is not a hormone but it is a very important prohormone secreted in large amounts by the adrenals in humans and other primates, but not in lower species...
  82. ncbi Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases?
    Boaz Robinzon
    Department of Biochemistry, University of Louisville Health Science Center, Louisville, KY 40292, USA
    Arch Biochem Biophys 412:251-8. 2003
    The cytochrome p450-dependent formation and subsequent interconversion of dehydroepiandrosterone (DHEA) metabolites 7 alpha-hydroxy-DHEA (7 alpha-OH-DHEA), 7 beta-hydroxy-DHEA (7 beta-OH-DHEA), and 7-oxo-DHEA was observed in human, pig, ..
  83. ncbi Ovarian androgen production in postmenopausal women
    Robin H Fogle
    Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA
    J Clin Endocrinol Metab 92:3040-3. 2007
    ..Several studies previously reported that the postmenopausal ovary produces androgens. However, these findings have recently been questioned in a group of women with adrenal insufficiency...
  84. ncbi Liquid chromatography-tandem mass spectrometry assay for androstenedione, dehydroepiandrosterone, and testosterone with pediatric and adult reference intervals
    Mark M Kushnir
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA
    Clin Chem 56:1138-47. 2010
    ..We developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for simultaneous measurement of androstenedione, dehydroepiandrosterone (DHEA), and testosterone in these patients.
  85. ncbi Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart
    Shota Nakamura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan
    Circulation 110:1787-93. 2004
    ..This study examined the production of dehydroepiandrosterone (DHEA) in human heart and elucidated the possible physiological significance...
  86. ncbi Low serum levels of dehydroepiandrosterone sulfate predict all-cause and cardiovascular mortality in elderly Swedish men
    Claes Ohlsson
    Wallenberg Laboratory for Cardiovascular Research, Institute of Medicine, University of Gothenburg, S 413 45 Gothenburg, Sweden
    J Clin Endocrinol Metab 95:4406-14. 2010
    The age-related decline in dehydroepiandrosterone (DHEA) levels is thought to be of importance for general and vascular aging. However, data on the association between DHEA and mortality are conflicting.
  87. ncbi Dehydroepiandrosterone supplementation in assisted reproduction: rationale and results
    Leonidas Mamas
    3 Kifissias Av, Marousi 15123, Athens, Greece
    Curr Opin Obstet Gynecol 21:306-8. 2009
    To present the possible positive effect of dehydroepiandrosterone administration in assisted reproduction and especially in poor responders, women with diminished ovarian reserve, premature ovarian failure and premature ovarian aging in ..
  88. ncbi Corticosterone and dehydroepiandrosterone have opposing effects on adult neuroplasticity in the avian song control system
    Amy E M Newman
    Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    J Comp Neurol 518:3662-78. 2010
    ..In rat hippocampus, supraphysiological doses of dehydroepiandrosterone (DHEA; a sex steroid precursor synthesized in the gonads, adrenals, and brain) have antiglucocorticoid ..
  89. pmc Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex
    Masatoshi Suzuki
    Department of Anatomy and the Waisman Center, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705 2280, USA
    Proc Natl Acad Sci U S A 101:3202-7. 2004
    b>Dehydroepiandrosterone (DHEA) is a neurosteroid with potential effects on neurogenesis and neuronal survival in humans...
  90. pmc Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans
    Edward P Weiss
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging (Albany NY) 3:533-42. 2011
    Plasma dehydroepiandrosterone (DHEA) decreases ~80% between ages 25 and 75 yr. In a preliminary study, we found that 6 mo of DHEA replacement improved insulin action in elderly individuals...
  91. ncbi Effects of dehydroepiandrosterone administration on rat hepatic metabolism following thermal injury
    Scott Banta
    Center for Engineering in Medicine Surgical Services, Shriners Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Surg Res 127:93-105. 2005
    ..Recently, there has been interest in using dehydroepiandrosterone (DHEA) as a treatment for trauma patients, and enhanced survival and immune function have been reported ..
  92. ncbi Dehydroepiandrosterone (DHEA) treatment in vitro inhibits adipogenesis in human omental but not subcutaneous adipose tissue
    S P L Rice
    Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Mol Cell Endocrinol 320:51-7. 2010
    b>Dehydroepiandrosterone (DHEA), a precursor sex steroid, circulates in sulphated form (DHEAS)...
  93. pmc A novel dehydroepiandrosterone analog improves functional recovery in a rat traumatic brain injury model
    Amir S Malik
    Department of Neurosurgery, University of Texas Health Science Center, Houston, Texas, USA
    J Neurotrauma 20:463-76. 2003
    The purpose of this study was to investigate the efficacy of a novel steroid, fluasterone (DHEF, a dehydroepiandrosterone (DHEA) analog), at improving functional recovery in a rat model of traumatic brain injury (TBI)...
  94. ncbi The impact of infectious diseases upon neuroendocrine circuits
    Ana Rosa Perez
    Institute of Immunology, School of Medical Sciences, National University of Rosario, Rosario, Argentina
    Neuroimmunomodulation 16:96-105. 2009
    ....
  95. ncbi DHEA treatment: myth or reality?
    Bruno Allolio
    Dept Medicine, Endocrine and Diabetes Unit, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Trends Endocrinol Metab 13:288-94. 2002
    b>Dehydroepiandrosterone (DHEA) and its sulfate ester are major secretory products of the human adrenal...
  96. ncbi Cortisol, the cortisol-dehydroepiandrosterone ratio, and pro-inflammatory cytokines in patients with current major depressive disorder comorbid with borderline personality disorder
    Kai G Kahl
    Department of Psychiatry and Psychotherapy, University of Lubeck, Lubeck, Germany
    Biol Psychiatry 59:667-71. 2006
    ..Therefore, our study aimed at examining serum profiles of cortisol, cytokines, and the cortisol/dehydroepiandrosterone (cortisol/DHEA) ratio in MDD/BPD patients and a healthy comparison group.
  97. ncbi Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue
    L Dalla Valle
    Comparative Endocrinology Laboratory, Department of Biology, University of Padova, Via U Bassi 58 B, 35131 Padova, Italy
    J Endocrinol 190:129-39. 2006
    ..Instead, our data support an intracrine role of adipose tissue, in which adrenal dehydroepiandrosterone sulfate (DHEA-S), the most abundant circulating androgen in man, is selectively uptaken, desulfated, and ..
  98. ncbi Dehydroepiandrosterone, dehydroepiandrosterone sulfate and related steroids: their role in inflammatory, allergic and immunological disorders
    Joseph S Dillon
    Division of Endocrinology, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, The University of Iowa, VA Medical Center, Room 3E10, Iowa City, Iowa 52246, USA
    Curr Drug Targets Inflamm Allergy 4:377-85. 2005
    b>Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are metabolic intermediates in the production of potent androgens, estrogens and other less well-characterized steroids...
  99. ncbi Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial
    P R Casson
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Fertil Steril 70:107-10. 1998
    ..To determine the effect of administering 6 months of oral postmenopausal DHEA therapy on serum DHEA, DHEAS, and T levels and on physiologic endpoints including lipoproteins and insulin-like growth factor-I (IGF-I)...
  100. ncbi Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells
    Itsuhiro Takizawa
    Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1, Niigata 951 8510, Japan
    Cancer Lett 297:226-30. 2010
    ..suppressed the intracellular production of androstenedione, testosterone, and dihydrotestosterone from dehydroepiandrosterone in LNCaP-FGC cells...
  101. ncbi Placebo-controlled trial of dehydroepiandrosterone (DHEA) for treatment of nonmajor depression in patients with HIV/AIDS
    Judith G Rabkin
    New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 163:59-66. 2006
    Subsyndromal major depressive disorder is common among HIV-positive adults. This study was designed to assess the efficacy of dehydroepiandrosterone (DHEA) as a potential treatment.

Research Grants66

  1. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..protein, white blood count, albumin, uric acid, creatinine, serum cholesterol, glycosylated hemoglobin, dehydroepiandrosterone sulfate (DHEAS &DHEA), fasting glucose and insulin resistance, telomere length, blood pressure, heart ..
  2. Modulation of immune senescence by androgen treatment in aged male macaques
    Henryk F Urbanski; Fiscal Year: 2013
    ..age also results in significant perturbations in the levels of circulating androgens (testosterone and dehydroepiandrosterone (DHEA)), which has been linked to sarcopenia, osteoporosis, cardiovascular disease and diabetes...
  3. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..The proposed project builds on a recent double-blind, placebo- controlled trial of dehydroepiandrosterone (DHEA) and estrogen replacement therapy (ERT) in adolescents with AN...
  4. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..We have also shown that plasma levels of the adrenal steroid, dehydroepiandrosterone (DHEA), fall markedly around this time...
  5. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..as: abnormal levels of maternal-fetal hormones during mid-gestation indicative of stress (CRH, dehydroepiandrosterone-sulfate (DHEA-S), human chorionic gonadotropin (hCG), and bioactive androgens);and high levels of pro- ..
  6. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
    ..half of pregnancy, we have shown that estrogen represses fetal zone growth and production of the androgens dehydroepiandrosterone (DHA)/DHA sulfate (DHAS), although fetal ACTH levels were unaltered...
  7. Cognition in Rhesus Macaques in Relation to Age and Endocrine Status
    Henryk F Urbanski; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In men and male rhesus macaques testosterone (T) and dehydroepiandrosterone (DHEA, an adrenal androgen precursor) show characteristic 24-hour patterns in the circulation, and both show significant age-..
  8. Risk Factors for Ischemic Stroke in Women
    Kathryn M Rexrode; Fiscal Year: 2012
    ..Specifically, we will test whether testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS), and sex hormone binding globulin (SHBG) might mediate hormonal risk of ischemic stroke...
  9. COX Inhibition & Musculoskeletal Responses to Exercise
    Wendy M Kohrt; Fiscal Year: 2010
    ..Therefore, knowledge of whether a drug as widely used as ibuprofen impairs the beneficial adaptations to exercise is deemed to be of high clinical significance. ..
  10. Adrenal function and adverse CV outcomes at age 6 after extremely preterm birth
    Kristi L Watterberg; Fiscal Year: 2013
    ..and anthropometrics, (2) salivary cortisol response to stress and diurnal secretion patterns;(3) salivary dehydroepiandrosterone (DHEA);(4) salivary cell DNA methylation at specific gene sites affecting corticosteroid regulation...
  11. Brain Reward Circuits and Computational Modeling in Adolescent Anorexia Nervosa
    GUIDO KW FRANK; Fiscal Year: 2013
    ..In Aim 3. We will test the hypothesis that the stress, feeding and reward related hormones cortisol, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S), will be associated with increased reward sensitivity in adolescent AN...
  12. TYPE II 3BETA HSD GENE--REGULATION OF DHEAS SYNTHESIS
    Peter Hornsby; Fiscal Year: 2009
    ..In humans and a few other primates, the adrenal cortex in the adult individual secretes androgen precursors, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS), as well as glucocorticoids and mineral-corticoids...
  13. PREMENOPAUSAL HORMONE LEVELS AND RISK OF BREAST CANCER
    Susan E Hankinson; Fiscal Year: 2011
    ..breast cancer and plasma levels of the sex steroids estradiol, androstenedione, testosterone, and dehydroepiandrosterone sulfate...
  14. Stress and Drug Use Vulnerability in Rural African Americans
    Ezemenari M Obasi; Fiscal Year: 2010
    ..Such research is needed in order to inform theory, research, prevention, and intervention efforts aimed at elimination health disparities that disproportionately impact this community. ..
  15. Integrative Pathways to Health and Illness: Testing Older Cohort Hypotheses
    Carol D Ryff; Fiscal Year: 2013
    ..The expanded MIDUS Refresher will lay the foundation for future tracking how economic hardship is changing the life course of different cohorts of American adults. ..
  16. MOLECULAR AND METABOLIC ASPECTS OF IMPLANTATION
    Kelle H Moley; Fiscal Year: 2013
    ....
  17. Causes and Impact of Minority Stress on Health and Development in Youth
    Margaret Rosario; Fiscal Year: 2013
    ..abstract_text> ..
  18. Risk for Child Psychopathology: A Twin-Study Perspective
    HAROLD HILL GOLDSMITH; Fiscal Year: 2011
    ..The knowledge gained should inform efforts toward early detection, improved interventions, and better classification of childhood disorders. ..
  19. Biobehavioral Mechanisms for Severe Disruptive Behavior in Adolescent Girls
    ELIZABETH ANNE SHIRTCLIFF; Fiscal Year: 2012
    ..noninvasively collected ten times across two days to capture the diurnal rhythm of cortisol, testosterone, dehydroepiandrosterone (DHEA), and estradiol...
  20. Psychoeducation for BMT caregivers: Biobehavioral markers and outcome
    Mark L Laudenslager; Fiscal Year: 2012
    ..abstract_text> ..
  21. Assessing the role of androgens in breast cancer risk
    Susan E Hankinson; Fiscal Year: 2013
    ..these, 1,151 postmenopausal cases (and age-matched controls) also have plasma testosterone and dehydroepiandrosterone sulfate (DHEAS) levels available...
  22. HUMAN CYTOSOLIC SULFOTRANSFERASES
    Charles N Falany; Fiscal Year: 2013
    ..Planar steroids such as dehydroepiandrosterone (DHEA) can bind in both the presence and absence of PAPS, whereas bulkier substrates such as raloxifene, ..
  23. Association of Androgen Receptor Polymorphisms with Damage in SLE
    Betty P Tsao; Fiscal Year: 2013
    ..These data suggested a heightened response to testosterone and dehydroepiandrosterone (DHEA) binding mediated by enhanced androgen transactivation activity of short CAG repeat in AR might be a ..
  24. Physiologic Cardiovascular & Uterine eNOS Responses:Role of Endogenous Estrogen
    Ronald R Magness; Fiscal Year: 2010
    ..Data generated with the aromatase inhibitor Letrozole will directly define the role of placental estrogen produced at the maternal: fetal interface in regulating uteroplacental blood flows. ..
  25. Stress and Drug Use Vulnerability in the African American Community
    Ezemenari M Obasi; Fiscal Year: 2013
    ..Findings from this study will identify causal mechanisms of drug addictions that will advance theory, research, prevention, and treatments aimed at addressing this growing public health problem. ..
  26. Imaging Brain, Neurocognitive and Pubertal Maturation During Adolescence
    Elizabeth R Sowell; Fiscal Year: 2013
    ..physical sexual maturation (using Tanners staging), and hormonal (cortisol, testosterone, estrogen and Dehydroepiandrosterone (DHEA) using saliva samples) data as well as measures of daily stress...
  27. Endocrine correlates of psychopathic traits in children: a multi-system approach
    ANDREA LORAINE GLENN; Fiscal Year: 2011
    ..By studying these traits in a relatively young age group, we may be able to intervene early, when this group of potentially chronic, severe offenders may be more amenable to intervention. ..
  28. Molecular Mechanisms of Adrenarche
    William E Rainey; Fiscal Year: 2013
    ..Definition of this novel series of adrenal androgens will also provide new biomarkers of adrenal dysregulation that may have implications not only in PA but also in women with adrenal-related hyperandrogenism. ..
  29. Exploring Neurological &Endocrine Determinants of Risk Behavior Decision-Making
    Jacinda K Dariotis; Fiscal Year: 2013
    ..Aim 2: Assess, via four salivary measures per day, whether testosterone (T) and dehydroepiandrosterone (DHEA) levels and diurnal patterns vary as a function of the cognitive control and socio-emotional network ..
  30. Cooperative steroidogenic inhibition for treatment of advanced prostate cancer
    Nima Sharifi; Fiscal Year: 2013
    ..In Aim 2, the effect(s) of abiraterone acetate on the conversion from dehydroepiandrosterone to androstenedione by 3?HSD1 and 3?HSD2 will be characterized...
  31. The Fetal Adrenal Gland as a Predictor of Spontaneous Preterm Birth
    Ronald Wapner; Fiscal Year: 2012
    ..and fetal-placental mediators (CRH, fetal DHEA-S, etc). If successful, this study will be the first to define a fetally based marker of preterm birth and fully define this important pathway of preterm birth. ..
  32. Promoting Well-Being Across Adulthood: The Role of Conflict Avoidance
    Kira S Birditt; Fiscal Year: 2012
    ..abstract_text> ..
  33. Refinement and Validation of a Portable, Salivary Biosensor of Psychosocial Stres
    Vivek Shetty; Fiscal Year: 2010
    ....
  34. Family Exchanges Study II
    Karen L Fingerman; Fiscal Year: 2013
    ..This study has potential practical implications for improving support patterns and relationships within families and thus, individual health and well-being. ..
  35. Preclinical evaluation of DHEA as a treatment for alcoholism
    Mary Worrel Hulin; Fiscal Year: 2013
    ..abstract_text> ..
  36. SYNTHESIS OF STABLE ISOTOPE-LABELED STEROIDS FOR THE MEASUREMENT OF ENDOGENOUS S
    SCOTT LANDVATTER; Fiscal Year: 2011
    ..2-, 3-, and 4-methoxyestrogens, estriol, testosterone, estrone, estradiol, and androstenedione and dehydroepiandrosterone. The selected compounds are believed to play critical roles in various cancers and thus have the potential ..
  37. Daily Stress, Health and Well-Being of Family Caregivers
    Steven H Zarit; Fiscal Year: 2013
    ..Assays will be obtained for 3 key biomarkers with implications for health: cortisol, alphaamylase and dehydroepiandrosterone- sulfate (DHEA-S)...
  38. SYNTHESIS OF STABLE ISOTOPE-LABELED STEROIDS FOR THE MEASUREMENT OF ENDOGENOUS S
    SCOTT LANDVATTER; Fiscal Year: 2009
    ..2-, 3-, and 4-methoxyestrogens, estriol, testosterone, estrone, estradiol, and androstenedione and dehydroepiandrosterone. The selected compounds are believed to play critical roles in various cancers and thus have the potential ..
  39. PINEAL FUNCTION IN CHILDHOOD AND ADOLESCENCE
    Anita Cavallo; Fiscal Year: 1990
    ..Plasma concentrations of melatonin, LH, dehydroepiandrosterone (DHEA), testosterone (in males) and estradiol (in females) will be determined in hourly samples or in ..
  40. Association between the Y chromosome and androgens
    Kathryn Sandberg; Fiscal Year: 2007
    ..Serum concentrations of free testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate and dihydrotestosterone will be assessed by radioimmunoassay...
  41. Puberty, Immunity and Malnutrition in S. Japonicum
    Jonathan Kurtis; Fiscal Year: 2005
    ..A recent hypothesis states that the hormonal changes of puberty, e.g., increasing dehydroepiandrosterone (DHEA), not cumulative exposure, initiate and promote the development of protective immune responses to ..
  42. MECHANISMS OF ACTION IN DPP INTERVENTIONS
    Abbas Kitabchi; Fiscal Year: 2001
    ....
  43. Couples and Cancer: Building Partner Efficacy in Caring
    William Collinge; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  44. MBSR Intervention to reduce stress in AD caregivers
    Lisa Fredman; Fiscal Year: 2009
    ..The results will guide the design of a larger RCT of the effects of MBSR on reducing stress, and will provide insight into the physiological mechanisms of MBSR. ..
  45. NUCLEOSIDE TRANSPORT INHIBITORS FOR CANCER PREVENTION
    John Buolamwini; Fiscal Year: 2005
    ..potently antagonize the inhibitory effect of exogenous nucleosides on the antitumor promotion activity of dehydroepiandrosterone (DHEA) against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion in the JB6 cell ..
  46. HORMONAL DISTURBANCES IN ANOVULATORY-HIRSUTE PATIENTS
    TERENCE MC KENNA; Fiscal Year: 1980
    ..The plasma steroid profile (including testosterone, androstenedione, dehydroepiandrosterone (DHEA), and DHEA-sulfate, LH, FSH and prolactin blood levels were measured basally and in response to ..
  47. Regulation of P450c17 Lyase Activity in Adrenache
    Qing Dong; Fiscal Year: 2007
    ..occurs when the human adrenal begins to make large amounts of 19-carbon androgen precursors, especially dehydroepiandrosterone (DHEA). Children normally begin adrenarche at about age 8-9, before the onset of puberty...
  48. FLAVONOIDS BLOCK SULFATION-INDUCED CARCINOGEN ACTIVATION
    Thomas Walle; Fiscal Year: 1999
    ..the structure-activity relationship and kinetics for inhibition of human P form phenol-ST (P-PST) and dehydroepiandrosterone-ST (DHEA-ST) by flavonoids, using recombinant enzymes, model substrates for P-PST and DHEA-ST and HPLC ..
  49. ANDROGEN PRODUCTION IN ADRENARCHE AND PCOS
    WALTER MILLER; Fiscal Year: 2006
    ..peri-pubertal event when the human adrenal begins to make large amounts of 19-carbon steroids, especially dehydroepiandrosterone (DHEA). Children normally begin adrenarche at about age 8-9 before the onset of puberty...
  50. NONINVASIVE MEASURES OF STRESS & REPRODUCTIVE STERIODS
    Samuel Wasser; Fiscal Year: 1991
    ..Validation studies will focus on five steroids: estradiol (E2), progesterone (P4), cortisol (C), dehydroepiandrosterone (DHEA), and testosterone (T)...
  51. ACTIVE SITE STUDIES OF HUMAN SULFOTRANSFERASES
    Guangping Chen; Fiscal Year: 2003
    ..in both the substrate- binding site and PAPS binding site of human liver phenol- sulfating ST (P-PST-1), dehydroepiandrosterone ST (DHEA-ST), and estrogen ST (EST). 2...
  52. Targeting Androgen -IGF Interactions in Prostate Cancer
    Charles Ryan; Fiscal Year: 2009
    ..of AD are 1) stimulation of the androgen receptor (AR) by the adrenal androgens androstenedione and dehydroepiandrosterone (DHEA) and 2) stimulation of the AR by growth factors such as the insulin like growth factor- type 1 (IGF-..
  53. INHIBITION OF HIV REPLICATION BY DHEA AND ITS ANALOGS
    Earl Henderson; Fiscal Year: 1991
    ..b>Dehydroepiandrosterone (DHEA), a major adrenal secretory product in men and women, is a potent inhibitor of mammalian glucose-6- ..
  54. STRUCTURE OF MICROSOMAL ENZYMES--ESTROGEN BIOSYN
    Debashis Ghosh; Fiscal Year: 2000
    ..The long-term objective is structure-based design of inhibitors with high specificities, but mutually exclusive affinities for their respective targets, and no affinity for the estrogen receptor. ..
  55. IMMUNIZATION AGAINST ACTH AND PARTURITION
    Dean Myers; Fiscal Year: 2001
    ..ACTH) and to determine the effect of immunoneutralization of ACTH on both fetal adrenocortical function (dehydroepiandrosterone sulfate [DHEAS] and cortisol synthesis) and the length of gestation...
  56. CHEMOPREVENTION OF SKIN TUMORS BY DHEA ANALOGS
    Arthur Schwartz; Fiscal Year: 1993
    The naturally occurring adrenal steroid, dehydroepiandrosterone (DHEA), is a highly effective tumor chemopreventive agent in laboratory mice and rats...
  57. COGNITION, STEROIDS AND IMAGING IN CUSHINGS DISEASE
    MONICA STARKMAN; Fiscal Year: 2001
    ..In many patients with CD, testosterone and dehydroepiandrosterone (DHEA) are also markedly elevated...
  58. EFFECT OF SRIs ON GONADAL STEROIDS
    Margaret Altemus; Fiscal Year: 2006
    ..Currently, for the 30% of subjects with PMDD and OCD who do not respond to SRI treatment, there are few, if any, alternative pharmacologic strategies. ..
  59. NEUROIMMUNOLOGY OF AED IN OCULAR HSV-1 INFECTION
    Daniel Carr; Fiscal Year: 2001
    ..A metabolite of the endogenous hormone dehydroepiandrosterone, androstenediol (AED) has been found to protect mice from HSV-l infection by increasing interferon-alpha ..
  60. PLAN FOR A TRIAL OF DHEAS IN MYOTONIC DYSTROPHY
    Charles Thornton; Fiscal Year: 2000
    ..However, encouraging results of recent trials with dehydroepiandrosterone sulfate (DHEAS) have given hope that a helpful treatment may be available...
  61. Promoting Well-Being Across Adulthood: The Role of Conflict Avoidance
    Kira Birditt; Fiscal Year: 2009
    ..Thus, identifying the most beneficial coping strategies will help to improve the health and well-being of adults as they age. ..
  62. DHEA:PPAR-Dependent and Independent Mechanisms of Action
    Russell Prough; Fiscal Year: 2006
    ..abstract_text> ..
  63. FOUR WEEK ORAL COMPARATIVE ENDOCRINOLOGY STUDIES
    Barry Levine; Fiscal Year: 1999
    ..b>Dehydroepiandrosterone (DHEA) is a major steroid precursor secreted by the adrenal cortex...
  64. DHEA: A NEUROSTEROID MODULATING AGGRESSION
    Neal Simon; Fiscal Year: 2003
    ..g., anxiety, memory, immune function, problems associated with aging). One of these compounds, dehydroepiandrosterone (DHEA), is a powerful inhibitor of aggression in murine models when given for fifteen days and potentially ..
  65. Role of Pentose Cycle on PDT Response
    STEPHEN TUTTLE; Fiscal Year: 2006
    ..In specific aim 2, we will determine if chemical inhibitors of G6PD, such as, dehydroepiandrosterone (DHEA), increase the sensitivity of R3230Ac and MCF7 breast cancer cells to LeutrinR-based PDT, in vitro...
  66. The VETSA Longitudinal Twin Study of Cortisol and Aging
    William Kremen; Fiscal Year: 2007
    ..Using multivariate twin analytic approaches, we will determine the extent of genetic, and shared and unique environmental factors influencing cortisol in midlife as well as their association with other key measures. ..