Genomes and Genes
Summary: A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
Publications340 found, 100 shown here
- Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndromeMaria Fleseriu
Northwest Pituitary Center, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Clin Endocrinol Metab 97:2039-49. 2012..Cushing's syndrome (CS) is a disorder associated with significant morbidity and mortality due to prolonged exposure to high cortisol concentrations...
- Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm laborOksana Shynlova
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
J Immunol 181:1470-9. 2008....
- Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expressionChelsea R Tieszen
Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, SD, USA
BMC Cancer 11:207. 2011b>Mifepristone (MF) has been largely used in reproductive medicine due to its capacity to modulate the progesterone receptor (PR)...
- RU486 (mifepristone): mechanisms of action and clinical usesF Cadepond
INSERM U33, , France
Annu Rev Med 48:129-56. 1997RU486 (mifepristone) has proved to be a remarkably active antiprogesterone and antiglucocorticosteroid agent in human beings...
- A conditional tissue-specific transgene expression system using inducible GAL4T Osterwalder
Department of Molecular, Cellular, and Developmental Biology, and Pharmacology Department, Yale University, P O Box 208103, New Haven, CT 06511, USA
Proc Natl Acad Sci U S A 98:12596-601. 2001..that its transcriptional activity within the target tissues depends on the presence of the activator RU486 (mifepristone)...
- Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapyCarlos D Gamarra-Luques
Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 414 East Clark Street, Vermillion, SD, USA
BMC Cancer 12:200. 2012..In this work we questioned whether the synthetic steroid mifepristone, which as monotherapy inhibits the growth of ovarian cancer cells, is capable of preventing repopulation of ..
- Progesterone is essential for maintenance and growth of uterine leiomyomaHiroshi Ishikawa
Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, Department of Obstetrics and Gynecology, 4th Floor, Suite 4 127, 303 East Superior Street, Chicago, Illinois 60611, USA
Endocrinology 151:2433-42. 2010..Taken together, our findings define that volume maintenance and growth of human UL are progesterone dependent...
- Mifepristone for the treatment of uterine leiomyomas: a randomized controlled trialJosep Lluis Carbonell Esteve
Clinica Mediterrania Medica, Valencia, Spain
Obstet Gynecol 112:1029-36. 2008To estimate the efficacy of daily administration of 5 mg compared with 10 mg of mifepristone for the treatment of uterine myomas.
- Mifepristone inhibits ovarian cancer cell growth in vitro and in vivoAlicia A Goyeneche
Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota, Vermillion, South Dakota 57069, USA
Clin Cancer Res 13:3370-9. 2007These studies were designed to determine whether the synthetic steroid mifepristone inhibits ovarian cancer growth in vitro and in vivo and the molecular mechanisms involved.
- Differential localization and activity of the A- and B-forms of the human progesterone receptor using green fluorescent protein chimerasC S Lim
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, Maryland 20892 5055, USA
Mol Endocrinol 13:366-75. 1999..The causes for and implications of this differential localization of the A and B forms of the human PR are discussed...
- Low-dose mifepristone in treatment of uterine leiomyoma: a randomised double-blind placebo-controlled clinical trialMadhu Bagaria
Department of Obstetrics and Gynaecology, University College of Medical Sciences, Delhi, India
Aust N Z J Obstet Gynaecol 49:77-83. 2009To evaluate the effect of low-dose mifepristone on leiomyoma-related symptoms, uterine and leiomyoma in women with symptomatic leiomyomata.
- Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetesA I Taylor
The SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
Horm Metab Res 41:899-904. 2009..001). These data demonstrate wide-ranging effects of glucocorticoid receptor antagonism on gene expression and metabolism, illustrating the therapeutic potential of specific glucocorticoid receptor antagonists in obesity-related diabetes...
- Clinical utility of progesterone receptor modulators and their effect on the endometriumIrving M Spitz
Institute of Hormone Research and Ben Gurion University of the Negev, Jerusalem, Israel
Curr Opin Obstet Gynecol 21:318-24. 2009In view of the spate of recent publications related to mifepristone and some second generation progesterone receptor modulators (PRMs), this appears to be an opportune time to view the clinical status of these compounds.
- Effects of mifepristone on invasive and metastatic potential of human gastric adenocarcinoma cell line MKN-45 in vitro and in vivoDa qiang Li
State Key Laboratory of Ultrasound Engineering in Medicine, Chongqing Medical University PO Box 153, Chongqing 400016, China
World J Gastroenterol 10:1726-9. 2004To investigate the effects of mifepristone on the invasive and metastatic potential of human gastric adenocarcinoma cell line MKN-45 and its mechanisms.
- The transcriptional response to chronic stress and glucocorticoid receptor blockade in the hippocampal dentate gyrusNicole A Datson
Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands
Hippocampus 22:359-71. 2012..studies demonstrated that glucocorticoid receptor (GR) blockade by a brief treatment with the GR antagonist mifepristone (RU486) rapidly reverses the stress and glucocorticoid effects on neurogenesis...
- Advances in medical therapies for Cushing's syndromeNicholas A Tritos
Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Discov Med 13:171-9. 2012..b>Mifepristone, a type 2 glucocorticoid receptor antagonist, was recently approved by the FDA as a new therapy for CS...
- p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilizationJunaid A Khan
Institut National de la Santé et de la Recherche Médicale Unité 693, Universite Paris Sud, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
Mol Endocrinol 25:1710-24. 2011..Imbalance in PRA/PRB ratio frequently associated with carcinogenesis might be a direct consequence of disorders in MAPK signaling that might switch cellular responses to hormonal stimuli and contribute towards pathogenesis...
- The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonistsMyles C Hodgson
Division of Hematology Oncology and Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 280:6511-9. 2005..as bicalutamide that are currently in use for prostate cancer treatment can also mediate NCoR recruitment, but mifepristone (RU486) at nanomolar concentrations is unique in its ability to markedly enhance the AR-NCoR interaction...
- Acute glucocorticoid administration rapidly suppresses basal and stress-induced hypothalamo-pituitary-adrenal axis activityMarcus H Andrews
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, United Kingdom
Endocrinology 153:200-11. 2012..Thus, in rats, glucocorticoid receptor activation rapidly suppresses basal and stress-induced HPA activity that operates, at least in part, through a central mechanism of action...
- Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorderAllan H Young
Stanley Research Centre, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
Neuropsychopharmacology 29:1538-45. 2004..this hypothesis, 20 bipolar patients were treated with 600 mg/day of the corticosteroid receptor antagonist mifepristone (RU-486) or placebo for 1 week in a double-blind crossover design...
- Comparative effectiveness, safety and acceptability of medical abortion at home and in a clinic: a systematic reviewThoai D Ngo
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, England, UK
Bull World Health Organ 89:360-70. 2011..To compare medical abortion practised at home and in clinics in terms of effectiveness, safety and acceptability...
- Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cellsPing Yin
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA
Cancer Res 70:1722-30. 2010..Taken together, using a ChIP-cloning approach, we uncovered KLF11 as an integrator of PR signaling and proliferation in uterine leiomyoma cells...
- Regulation of bim in glucocorticoid-mediated osteoblast apoptosisB Espina
The Botnar Research Centre, Oxford Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedic Surgery, Oxford, UK
J Cell Physiol 215:488-96. 2008..These findings suggest that Bim is a novel regulator of osteoblast apoptosis and may be a therapeutic target...
- Progestin-dependent progression of human breast tumor xenografts: a novel model for evaluating antitumor therapeuticsYayun Liang
Dalton Cardiovascular Research Center, Veterinary Pathobiology, and Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
Cancer Res 67:9929-36. 2007..Such a model could potentially be used to screen for safer antiprogestins, antiangiogenic agents, or for compounds that reactivate mutant p53 and prevent progestin-dependent progression of breast disease...
- Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seekingJeffrey A Simms
Preclinical Development Group, Ernest Gallo Clinic and Research Center at University of California San Francisco, Emeryville, CA 94608, USA
Neuropsychopharmacology 37:906-18. 2012..The objective of this study was to determine whether mifepristone, a glucocorticoid receptor antagonist, plays a role in ethanol self-administration and reinstatement...
- Cisplatin cytotoxicity is increased by mifepristone in cervical carcinoma: an in vitro and in vivo studyRafael Jurado
Laboratorio de Farmacologia, Subdireccion de Investigacion Basica, Instituto Nacional de Cancerología INCan, Mexico D F, Mexico
Oncol Rep 22:1237-45. 2009We investigated the ability of mifepristone, an anti-progestin drug, to modulate the cytotoxic effect of cisplatin in two cervical cancer cell lines and in human xenograft cervical tumors...
- Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptorLiang Nian Song
Department of Oncology, Lombardi Cancer Center, Georgetown University, 3800 Reservoir Road, Northwest, Washington, D C 20057, USA
Mol Endocrinol 18:70-85. 2004b>Mifepristone is a potent antagonist of steroid hormone receptors such as glucocorticoid and progesterone receptors...
- Effect of mifepristone for symptomatic leiomyomata on quality of life and uterine size: a randomized controlled trialKevin Fiscella
Department of Family Medicine, Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14620, USA
Obstet Gynecol 108:1381-7. 2006To assess the effect of low-dose mifepristone on quality of life, pain, bleeding, and uterine size among women with symptomatic leiomyomata.
- Mifepristone for treatment of uterine leiomyoma. A prospective randomized placebo controlled trialM Engman
Department of Woman and Child Health, Division of Obstetrics and Gynaecology, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
Hum Reprod 24:1870-9. 2009..Uterine leiomyomas are widely prevalent and frequently cause menorrhagia. The major therapeutic option today is hysterectomy. Medical options are of highest interest...
- Brief treatment with the glucocorticoid receptor antagonist mifepristone normalizes the reduction in neurogenesis after chronic stressCharlotte A Oomen
SILS Centre for Neuroscience, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
Eur J Neurosci 26:3395-401. 2007..In the present study, we therefore questioned whether glucocorticoid receptor blockade by mifepristone can normalize the effects of chronic stress on adult neurogenesis...
- Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometriumR D Catalano
Department of Pathology, University of Cambridge, Cambridge, UK
Mol Hum Reprod 13:641-54. 2007In women, a single dose of the antiprogestin mifepristone (RU486) in the secretory phase rapidly renders the endometrium unreceptive and is followed by endometrial breakdown and menstruation within 72 h...
- The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific mannerHerve Tricoire
Unité BFA EAC 7059, Université Paris Diderot Paris7 CNRS, 4 rue Marie Andrée Lagroua Weill Hallé, Paris, France
Mech Ageing Dev 130:547-52. 2009..These results reveal a complex adult and sex-specific control of lifespan by steroid signalling in Drosophila...
- Preventing local regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 enhances angiogenesisGary R Small
Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK
Proc Natl Acad Sci U S A 102:12165-70. 2005....
- Corticosterone acutely prolonged N-methyl-d-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neuronsTaiki Takahashi
Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, University of Tokyo at Komaba, Meguro, Tokyo, Japan
J Neurochem 83:1441-51. 2002..These results imply that high levels of CORT induce a rapid and non-genomic prolongation of NMDA receptor-mediated Ca2+ elevation, probably via putative membrane surface receptors for CORT in the hippocampal neurons...
- Brain aging and Aβ₁₋₄₂ neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer's neurodegeneration with agingDaijun Ling
Department of Neuroscience, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
Acta Neuropathol 121:183-91. 2011..A chronic deterioration of the neuronal autophagy-lysosomal system is likely to be a key event in transitioning from normal brain aging to pathological aging leading to Alzheimer's neurodegeneration...
- Dynamics of the action of dFOXO on adult mortality in DrosophilaMaria E Giannakou
Centre for Research on Ageing, Department of Biology, University College London, London, UK
Aging Cell 6:429-38. 2007..The decreased mortality and increased lifespan of dFOXO overexpressing flies was uncoupled from any effect on female fecundity and from expression levels of Drosophila insulin-like peptides in the brain...
- Mifepristone-induced amenorrhoea is associated with an increase in microvessel density and glucocorticoid receptor and a decrease in stromal vascular endothelial growth factorNitish Narvekar
Contraceptive Development Network, Centre for Reproductive Biology, Edinburgh, UK
Hum Reprod 21:2312-8. 2006We have previously shown that the progesterone antagonist mifepristone is a contraceptive when given in a dose of 2 or 5 mg per day...
- Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesisJ L Mayer
Swammerdam Institute for Life Sciences, Centre for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
J Neuroendocrinol 18:629-31. 2006The glucocorticoid receptor antagonist mifepristone has been shown to rapidly and effectively ameliorate symptoms of psychotic major depression...
- RU486 did not exacerbate cytokine release in mice challenged with LPS nor in db/db miceBaichun Yang
Department of Metabolic Molecular Pharmacology, Research and Development, GlaxoSmithKline, Research Triangle Park, USA
BMC Pharmacol 8:7. 2008..We investigated the effects of RU486 on serum cytokines in db/db mice and on lipopolysaccharide (LPS)-induced circulating TNFalpha levels in both normal AKR mice and diet-induced obese (DIO) C57BL/6 mice...
- Daily low-dose mifepristone has contraceptive potential by suppressing ovulation and menstruation: a double-blind randomized control trial of 2 and 5 mg per day for 120 daysAudrey Brown
Contraceptive Development Network, Centre for Reproductive Biology, University of Edinburgh, Edinburgh, EH3 9ET, United Kingdom
J Clin Endocrinol Metab 87:63-70. 2002..double-blind randomized trial, we have explored the contraceptive potential of two doses of the P antagonist mifepristone in healthy volunteers in Edinburgh and Shanghai...
- Human glucocorticoid receptor beta binds RU-486 and is transcriptionally activeLaura J Lewis-Tuffin
Laboratory of Signal Transduciton, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Mol Cell Biol 27:2266-82. 2007....
- A single-day treatment with mifepristone is sufficient to normalize chronic glucocorticoid induced suppression of hippocampal cell proliferationPu Hu
Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 7:e46224. 2012..Earlier we showed that administration of the glucocorticoid receptor antagonist mifepristone during the final 4 days of a 21 days period of corticosterone treatment fully normalized the number of newborn ..
- Mifepristone abrogates repopulation of ovarian cancer cells in between courses of cisplatin treatmentElizabeth M Freeburg
Sanford School of Medicine, The University of South Dakota, Vermillion, SD 57069, USA
Int J Oncol 34:743-55. 2009..In this study, we tested the hypothesis that mifepristone (MF), a steroid compound with demonstrated growth inhibition activity in ovarian cancer, should be efficacious ..
- Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequencesMathias V Schmidt
Max Planck Institute of Psychiatry, Munich, Germany
Endocrinology 150:2709-16. 2009..Postnatal glucocorticoid excess results in an altered stress-coping behavior in adult animals, with no effects on anxiety like behavior or cognition...
- Blocking mineralocorticoid receptors prior to retrieval reduces contextual fear memory in miceMing Zhou
Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 6:e26220. 2011..We tested here whether blockade of MRs or GRs during retrieval also affects subsequent expression of fear memory...
- Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cellsXia Luo
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 94:4533-9. 2009..Until now, little is known about the roles of LAT2/4F2hc in the regulation of the growth of human uterine leiomyoma...
- Mifepristone: pharmacology and clinical impact in reproductive medicine, endocrinology and oncologyAnnie Im
University of Pittsburgh, Division of Hematology Oncology, Department of Medicine, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
Expert Opin Pharmacother 11:481-8. 2010b>Mifepristone is a synthetic selective progesterone-receptor modulator (SPRM) that is widely used around the globe in the field of reproductive medicine...
- Distinguishing features of endometrial pathology after exposure to the progesterone receptor modulator mifepristoneJulietta Fiscella
Department of Pathology, School of Medicine and Dentistry, University of Rochester School of Medicine, Rochester, NY 14620, USA
Hum Pathol 42:947-53. 2011There is growing interest in the use of progesterone receptor modulators such as mifepristone for treatment of gynecologic and other conditions, but interest in progesterone receptor modulators is dampened by the effects of the agents on ..
- Revealing a steroid receptor ligand as a unique PPARγ agonistShengchen Lin
State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China
Cell Res 22:746-56. 2012..Our findings together indicate that steroid compounds may represent an alternative approach for designing non-TZD PPARγ ligands in the treatment of insulin resistance...
- A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1S Heck
Kernforschungszentrum Karlsruhe, Institut fur Genetik, Germany
EMBO J 13:4087-95. 1994..While DNA binding and activation of glucocorticoid-regulated promoters require GR dimerization, we present data that suggest that repression is a function of GR monomers...
- Progestin regulation of vascular endothelial growth factor in human breast cancer cellsS M Hyder
Department of Integrative Biology, Pharmacology and Physiology, University of Texas Health Sciences Center Houston, 77225, USA
Cancer Res 58:392-5. 1998....
- Dexamethasone has a central antiemetic mechanism in decerebrated catsChiu Ming Ho
Department of Anesthesiology, National Defense Medical Center Tri Service General Hospital, Rm 8113, No 161, Sec 6, Minchiuan E Rd, Taipei 114, Taiwan
Anesth Analg 99:734-9, table of contents. 2004..4, P < 0.05; 0.1 microg, 2.9 +/- 0.9 versus 0.3 +/- 0.5, P < 0.05) induced by xylazine. Pretreatment with mifepristone, a glucocorticoid receptor antagonist, blocked the antiemetic effect of dexamethasone in the bilateral nuclei ..
- Systematic review of mifepristone for the treatment of uterine leiomyomataJody Steinauer
Department of Obstetrics, Gynecology, and Reproductive Sciences, San Francisco General Hospital, 1001 Potrero Avenue, Ward 6D 14, San Francisco, CA 94110, USA
Obstet Gynecol 103:1331-6. 2004To systematically review the effect of mifepristone on uterine leiomyoma size and symptoms and to summarize its adverse effects.
- Low-dose mifepristone inhibits endometrial proliferation and up-regulates androgen receptorNitish Narvekar
Contraceptive Development Network, Center for Reproductive Biology, Edinburgh, United Kingdom EH16 4SB
J Clin Endocrinol Metab 89:2491-7. 2004b>Mifepristone in daily low doses has contraceptive potential by inhibiting ovulation. Follicular development is maintained, and although the endometrium is exposed to unopposed estrogen, there are no signs of hyperplasia or atypia...
- A randomized trial to examine the effect of mifepristone on neuropsychological performance and mood in patients with bipolar depressionStuart Watson
Academic Psychiatry, Newcastle University, Newcastle upon Tyne, United Kingdom
Biol Psychiatry 72:943-9. 2012..We have previously demonstrated a beneficial effect on spatial working memory (SWM) of treatment for 1 week with the progesterone and glucocorticoid receptor antagonist mifepristone, evident 2 weeks after the cessation of treatment.
- Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expressionDaniel B Hardy
Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
Mol Endocrinol 20:2724-33. 2006..Based on these findings, we propose that PR may inhibit NF-kappaB activation of COX-2 gene expression and uterine contractility via ligand-dependent and ligand-independent mechanisms...
- Glucocorticoid receptor and sequential P53 activation by dexamethasone mediates apoptosis and cell cycle arrest of osteoblastic MC3T3-E1 cellsHui Li
Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
PLoS ONE 7:e37030. 2012..These data demonstrate that proliferation of MC3T3-E1 cell was significantly and directly inhibited by dexamethasone treatment via aberrant GR activation and subsequently P53 activation...
- Mifepristone treatment improves length and quality of survival of mice with spontaneous lung cancerJerome H Check
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Camden, NJ, USA
Anticancer Res 30:119-22. 2010..b>Mifepristone has not only been shown to down-regulate PIBF expression by human leukemic cell lines but has also been shown ..
- Clinical pharmacokinetics of mifepristoneO Heikinheimo
Department of Biomedicine, University of Helsinki, Finland
Clin Pharmacokinet 33:7-17. 1997b>Mifepristone is a steroidal antiprogestin and antiglucocorticoid acting at the receptor level...
- Hormonal regulation and localization of estrogen, progestin and androgen receptors in the endometrium of nonhuman primates: effects of progesterone receptor antagonistsOv D Slayden
Division of Reproductive Sciences, Oregon National Primate Research Center, 505 NW 185th Ave, Beaverton, OR 97006, USA
Arch Histol Cytol 67:393-409. 2004..This endometrial antiproliferative effect is the basis of the clinical use of PA to control various diseases such as endometriosis...
- Treatment of uterine myoma with 5 or 10mg mifepristone daily during 6 months, post-treatment evolution over 12 months: double-blind randomised clinical trialJosep Ll Carbonell Esteve
Mediterránea Médica Clinic, Valencia, Castello, Valencian Country, Spain
Eur J Obstet Gynecol Reprod Biol 161:202-8. 2012To evaluate the efficacy and safety of 5 and 10mg doses of mifepristone for 6 months for the treatment of uterine fibroids and to check those results at 1 year post-treatment.
- Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2Alicia A Goyeneche
Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, SD, USA
Invest New Drugs 30:967-80. 2012..Our results suggest that, as a consequence of their cytostatic and lethal effects, antiprogestin steroids of well-known contraceptive properties emerge as attractive new agents to be repositioned for ovarian cancer therapeutics...
- Mifepristone prevents stress-induced apoptosis in newborn neurons and increases AMPA receptor expression in the dentate gyrus of C57/BL6 miceMaría Llorens-Martín
CSIC, Madrid, Spain
PLoS ONE 6:e28376. 2011..Furthermore, we evaluated the effects of the glucocorticoid receptor (GR) antagonist mifepristone on the cell death induced by the Porsolt test...
- The effect of mifepristone on breast cell proliferation in premenopausal women evaluated through fine needle aspiration cytologyM Engman
Division of Obstetrics and Gynecology, Department of Woman and Child Health, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
Hum Reprod 23:2072-9. 2008Progestins as well as estrogens have a role in breast cell proliferation and the development of breast cancer. Here, the effect of mifepristone on cell proliferation in human breast tissue in vivo was studied in premenopausal women.
- Effects of mifepristone on endometrial receptivityKristina Gemzell Danielsson
Department of Woman and Child Health, Division for Obstetrics and Gynecology, Karolinska Hospital Institute, Stockholm S 171 76, Sweden
Steroids 68:1069-75. 2003..The effect of various doses and regimens of mifepristone on endometrial development and markers of receptivity has been studied...
- Ligand-specific dynamics of the progesterone receptor in living cells and during chromatin remodeling in vitroGeetha V Rayasam
Laboratory of Receptor Biology and Gene Expression, Building 41, B602, National Cancer Institute, National Institutes of Health, 41 Library Dr, Bethesda, MD 20892 5055, USA
Mol Cell Biol 25:2406-18. 2005....
- Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expressionKun Ma
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Am J Physiol Endocrinol Metab 285:E363-71. 2003..We propose that dexamethasone-induced muscle loss is mediated, at least in part, by the upregulation of myostatin expression through a glucocorticoid receptor-mediated pathway...
- Anti-progestins suppress the growth of established tumors induced by 7,12-dimethylbenz(a)anthracene: comparison between RU486 and a new 21-substituted-19-nor-progestinRonald D Wiehle
Repros Therapeutics Inc, The Woodlands, TX 77380, USA
Oncol Rep 18:167-74. 2007..These results indicate that anti-progestins should be developed for the chemoprevention and treatment of hormone-responsive breast cancer...
- Effect of low-dose mifepristone administration on day 2 after ovulation on transcript profiles in implantation-stage endometrium of rhesus monkeysD Ghosh
Department of Physiology, All India Institute of Medical Sciences, New Delhi, India
Reproduction 138:357-70. 2009..effect, we have compared transcript profiles for 409 known genes between control receptive stage (n=13), and mifepristone-induced desynchronized and non-receptive stage (n=12) monkey endometrial samples collected on days 4 (n=12) and ..
- Arousal and stress effects on consolidation and reconsolidation of recognition memoryMouna Maroun
Department of Neurobiology and Etiology, The Brain and Behavior Research Center, University of Haifa, Haifa, Israel
Neuropsychopharmacology 33:394-405. 2008....
- Dexamethasone inhibits proliferation of adult hippocampal neurogenesis in vivo and in vitroJong Bin Kim
Department of Biochemistry, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, Republic of Korea
Brain Res 1027:1-10. 2004..Taken these in vitro and in vivo results together, it is concluded that glucocorticoid receptor activation blocks only proliferation, but not differentiation, in hippocampal neurogenesis...
- Neuroprotective effect of mifepristone involves neuron depolarizationA M Ghoumari
INSERM UMR788 and University Paris XI, Bicetre, France
FASEB J 20:1377-86. 2006..the mechanism of this developmental apoptosis, we took advantage of its inhibition by the steroid analog mifepristone. This effect did not involve the classical steroid nuclear receptors...
- Medical abortion in early pregnancy: experience in ChinaLinan Cheng
Shanghai Institute of Family Planning Technical Instruction, International Peace Maternity and Child Health Hospital, China Welfare Institute, Shanghai 200030, People s Republic of China
Contraception 74:61-5. 2006..b>Mifepristone is now produced in three companies in China and is commonly used with PGs for medical abortion.
- Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cellsMegan E Cavet
Pharmaceutical R and D, Bausch and Lomb, Inc, Rochester, NY 14609, USA
Mol Vis 16:1791-800. 2010..This study assessed the anti-inflammatory effects of mapracorat in an in vitro osmotic stress model which mimics some of the pathophysiological changes seen in dry eye...
- A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in DrosophilaJie Shen
Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
Aging (Albany NY) 1:191-211. 2009..expression of transgenes in Drosophila was produced using the Geneswitch system, wherein feeding the drug RU486/Mifepristone activates the artificial transcription factor Geneswitch...
- Successful long-term treatment of refractory Cushing's disease with high-dose mifepristone (RU 486)J W Chu
Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
J Clin Endocrinol Metab 86:3568-73. 2001..surgical, medical, and radiotherapeutic approaches, he responded dramatically to high-dose long-term mifepristone therapy (up to 25 mg/kg x d)...
- Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplayFrederick Barreau
Neuro Gastroenterology and Nutrition Unit, INRA, 180 chemin de Tournefeuille, BP 3, 31931 Toulouse Cedex 9, France
J Physiol 580:347-56. 2007..At 12 weeks of age, adult rats were treated with mifepristone (an antagonist of corticoid receptors), alpha-helical CRF((9-41)) (a non-specific CRF receptor antagonist), or ..
- Low-dose mifepristone for uterine leiomyomataSteven H Eisinger
Department of Family Medicine, School of Medicine, University of Rochester, Rochester, New York, USA
Obstet Gynecol 101:243-50. 2003To compare the effect of 5 and 10 mg of mifepristone on uterine leiomyoma size and symptoms, and to measure side effects.
- The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 valuesShimin Zhang
Division of Molecular Pathobiology, Department of Environmental and Infectious Disease Sciences, American Registry of Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
Steroids 72:600-8. 2007b>Mifepristone is an antagonist of the glucocorticoid receptor (GR) that also has significant agonist activity in some cell types...
- Preterm and term cervical ripening in CD1 Mice (Mus musculus): similar or divergent molecular mechanisms?Juan M Gonzalez
Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Reprod 81:1226-32. 2009..Our results indicate that the molecular mechanisms governing preterm and term cervical ripening are distinctly different...
- Mifepristone (RU486): a reviewD K Mahajan
Department of Obstetrics and Gynecology, Louisiana State University School of Medicine, Shreveport 71130, USA
Fertil Steril 68:967-76. 1997To review the literature concerning the mechanism of action and pharmacodynamics of mifepristone (RU486), potential new uses of RU486, and its current use not only as an abortifacient but also as therapy for endometriosis, leiomyoma, ..
- Corticosterone reduces dendritic complexity in developing hippocampal CA1 neuronsDeborah N Alfarez
Swammerdam Institute for Life Sciences, Center for Neuroscience, Universiteit van Amsterdam, Amsterdam, The Netherlands
Hippocampus 19:828-36. 2009..These findings suggest that it is relevant to maintain plasma corticosterone levels low during hippocampal development...
- Induction of antiproliferation and apoptosis in estrogen receptor negative MDA-231 human breast cancer cells by mifepristone and 4-hydroxytamoxifen combination therapy: a role for TGFbeta1Yayun Liang
Department of Surgery, Medical College of Georgia, Augusta, GA, USA
Int J Oncol 23:369-80. 2003b>Mifepristone (MIF) is an antiprogestin with potent anti-glucocorticoid and anti-androgen activity. MIF also appears to have anti-tumor activity independent of its ability to bind to nuclear receptors...
- Mifepristone-misoprostol abortion: a trial in rural and urban Maharashtra, IndiaKurus Coyaji
K E M Hospital, Pune, India
Contraception 66:33-40. 2002..the use of medical abortion in developing countries, we investigated the safety, efficacy, and acceptability of mifepristone-misoprostol abortion in the outpatient family planning departments of two urban hospitals and one rural ..
- Antiviral effects of mifepristone on human immunodeficiency virus type-1 (HIV-1): targeting Vpr and its cellular partner, the glucocorticoid receptor (GR)Elizabeth A Schafer
Department of Infectious Diseases and Microbiology, University of Pittsburgh, Graduate School of Public Health, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Antiviral Res 72:224-32. 2006..the HIV-1 LTR through glucocorticoid response element (GRE), an event that can be blocked by the GR antagonist, mifepristone. Results demonstrated that Vpr-induced transactivation of the HIV-1 LTR was inhibited by mifepristone in a dose-..
- Effect of long-term treatment with low-dose mifepristone on the endometriumD T Baird
Contraceptive Development Network, Centre for Reproductive Biology, University of Edinburgh, Academic Centre, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK
Hum Reprod 18:61-8. 2003b>Mifepristone in low daily doses has contraceptive potential by inhibiting ovulation and menstruation. Because follicular development is maintained, the endometrium is exposed to estrogen for prolonged periods unopposed by progesterone.
- Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexesE Smith
Department of Orthopaedic Surgery, Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
J Biol Chem 275:19992-20001. 2000..Thus, glucocorticoids induce premature attenuation of the osteoblast cell cycle, possibly contributing to the osteoporosis induced by these drugs in vivo...
- Mifepristone treatment of olanzapine-induced weight gain in healthy menColeman Gross
Corcept Therapeutics, Menlo Park, CA 94025, USA
Adv Ther 26:959-69. 2009..The objective of this study was to determine if mifepristone, a glucocorticoid receptor antagonist, could prevent olanzapine-induced weight gain.
- Differential response of progesterone receptor isoforms in hormone-dependent and -independent facilitation of female sexual receptivityShaila K Mani
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Endocrinol 20:1322-32. 2006..The data reveal the selective contributions of individual isoforms to the signaling pathways mediating female reproductive behavior...
- Menstrual-like changes in mice are provoked through the pharmacologic withdrawal of progesterone using mifepristone following induction of decidualizationX B Xu
Department of Cell Biology, National Research Institute for Family Planning, Beijing 100081, People s Republic of China
Hum Reprod 22:3184-91. 2007..Since progesterone action ablated pharmacologically may provide more insight into the mechanism of action, a mouse menstruation model using mifepristone was established.
- Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellumA M Ghoumari
Institut National de la Santé et de la Recherche Médicale U488, Batiment Gregory Pincus, 80 rue du General Leclerc, 94276 Kremlin Bicêtre, France
Proc Natl Acad Sci U S A 100:7953-8. 2003b>Mifepristone (RU486), which binds with high affinity to both progesterone and glucocorticosteroid receptors (PR and GR), is well known for its use in the termination of unwanted pregnancy, but other activities including neuroprotection ..
- ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactionsAshley M Vaughan
Department of Medicine, University of Washington, Seattle, WA 98195 6426, USA
J Lipid Res 44:1373-80. 2003..These studies show that ABCA1 redistributes cholesterol to cell-surface domains, where it becomes accessible for removal by apolipoproteins, consistent with a direct role of ABCA1 in cholesterol transport...
- A phase II study of mifepristone (RU-486) in castration-resistant prostate cancer, with a correlative assessment of androgen-related hormonesMary Ellen Taplin
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
BJU Int 101:1084-9. 2008To evaluate mifepristone (RU-486) in patients with castration-resistant prostate cancer (CRPC), with a correlative assessment of serum androgens and androgen metabolites
- Mifepristone (RU 486) in Cushing's syndromeSarah Johanssen
Endocrine and Diabetes Unit, Department of Internal Medicine I, University of Wuerzburg, Josef Schneider Street 2, 97080 Wuerzburg, Germany
Eur J Endocrinol 157:561-9. 2007b>Mifepristone (RU 486) blocks the action of cortisol by binding to the glucocorticoid receptor and, therefore, is of potential therapeutic value in Cushing's syndrome...
- Mifepristone: where do we come from and where are we going? Clinical development over a quarter of a centuryIrving M Spitz
Institute of Hormone Research and Ben Gurion University of the Negev, Jerusalem 92548, Israel
Contraception 82:442-52. 2010Administration of mifepristone followed by the prostaglandin, misoprostol, has been used successfully in the medical termination of pregnancy for over 25 years, and the method is registered in 35 countries...
- Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stressAynara C Wulsin
Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
Psychoneuroendocrinology 35:1100-12. 2010..The current study was designed to test the efficacy of mifepristone, a GR antagonist, in mitigating behavioral, neuroendocrine and central nervous system (CNS) responses to an ..
- Reversal of antiprogestin resistance and progesterone receptor isoform ratio in acquired resistant mammary carcinomasVictoria Wargon
Laboratory of Hormonal Carcinogenesis, Institute of Experimental Biology and Medicine National Research Council of Argentina CONICET, Obligado 2490, 1428 Buenos Aires, Argentina
Breast Cancer Res Treat 116:449-60. 2009....
- Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cellsJosue G Yague
Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain
Endocrine 35:252-61. 2009..We assessed whether vitamin D, dexamethasone, and the glucocorticoid receptor antagonist mifepristone regulate the aromatase gene in human glioma, neuroblastoma, and breast cancer cells...
- Vaginal misoprostol administered 1, 2, or 3 days after mifepristone for early medical abortion: A randomized trialE A Schaff
Reproductive Health Program, Department of Family Medicine, University of Rochester School of Medicine, 1000 South Ave, Box 101, Rochester, NY 14620, USA
JAMA 284:1948-53. 2000The conventional timing of misoprostol administration after mifepristone for medical abortion is 2 days, but more flexible intervals, which may make the regimen more convenient, have not been studied.
- [Effects of mifepristone on expression of estrogen receptor and progesterone receptor in cultured human eutopic and ectopic endometria]J Jiang
Department of Obstetrics and Gynecology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Zhonghua Fu Chan Ke Za Zhi 36:218-21. 2001OBJECTIVE: To investigate the effects of mifepristone on expression of estrogen receptor (ER) and progesterone receptor (PR) in cultured human eutopic and ectopic endometria...
- Mifepristone treatment improves length and quality of survival of mice with spontaneous leukemiaJerome H Check
Department of Obstetrics and Gynecology, The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital University Medical Center, Camden, New Jersey, USA
Anticancer Res 29:2977-80. 2009b>Mifepristone was found to suppress expression of the progesterone-induced blocking factor (PIBF). Progesterone-induced blocking factor suppresses natural killer cell activity...
- Mifepristone for Prevention of Breakthrough BleedingJohn Jain; Fiscal Year: 2004..b>Mifepristone is a competitive progesterone receptor antagonist...
- Chronic Nicotine's Activation of the HPA AxisTheodore Friedman; Fiscal Year: 2005..abstract_text> ..
- Suppression of Breakthrough Bleeding in LNG-IUS UsersOv Slayden; Fiscal Year: 2006..using subcutaneous Norplant contraception, BTB can be suppressed by intermittent antiprogestin therapy with mifepristone. NICHD has a new antiprogestin, CDB-2914, that is more potent than mifepristone...
- Individual differences in anxiety in femalesMohamed Kabbaj; Fiscal Year: 2006..Male rats will be used as positive controls. ..
- Ethanol Regulation of Serum Glucocorticoid Kinase IBLAIR N COSTIN; Fiscal Year: 2012..The work proposed here could shed light on molecular mechanisms underlying alcoholism and eventually have implications in the development of novel pharmacological agents for alcoholism or alcohol-related neurological disorders. ..
- Endocrine Targets for Prevention of Lung CancerRobert M Bigsby; Fiscal Year: 2012..On the other hand, using the antiprogestin, mifepristone, we will determine the role of PR in tumor progression...
- Glucocorticoids, Stress and Blood Pressure RegulationDeborah A Scheuer; Fiscal Year: 2013..The pellets will be composed of the following steroids: Cort, Mifepristone (a GR receptor antagonist), eplerenone (an MR receptor antagonist) and/or cholesterol...
- BRCA1 and progesterone receptors in breast cancerEva Y Lee; Fiscal Year: 2013..Consistently, treatment of these mice with the anti-progesterone, mifepristone (RU486), significantly delays or prevents mammary tumorigenesis...
- Novel Therapeutics in PTSD: A Randomized Clinical Trial of MifepristoneGerardo Villarreal; Fiscal Year: 2013..manipulation of the body's major stress system (the hypothalamic-pituitary-adrenal (HPA) axis) with mifepristone. At high doses mifepristone is a glucocorticoid receptor (GR) antagonist with peripheral and central nervous ..
- GCs, CRF and Stressor-Induced RelapseJohn R Mantsch; Fiscal Year: 2013..The ability of a rat model of excessive drug use to enhance CRF regulation of drug-seeking behavior in a manner that depends on secretion of glucocorticoid hormones will be tested. ..
- Antiprogestin therapy for ovarian cancerCARLOS MARCELO TELLERIA; Fiscal Year: 2012..Our laboratory demonstrated that single therapy with the prototypical antiprogestin mifepristone inhibits growth of ovarian cancer cells in vitro as well as in a preclinical in vivo animal model of ovarian ..
- MOLECULAR MECHANISM OF LEIOMYOMA GROWTH AND REGRESSIONGREGORY SCOTT SCHULTZ; Fiscal Year: 2011..This proposal will investigate how fibroids are developed and grow, and ways to prevent them, including their symptoms. ..
- Role of misoprostol in Clostridium sordellii endometritis in a rodent modelDavid M Aronoff; Fiscal Year: 2012DESCRIPTION (provided by applicant): The combination oral regimen of mifepristone (MFP;also known as RU-486) and misoprostol was FDA approved in 2000 to induce abortion medically...
- Extra / Intra-cellular Signaling in Novel 3-Dimensional Human Leiomyoma CulturesWILLIAM HENRY CATHERINO; Fiscal Year: 2013..One such medical therapy, mifepristone, decreases tumor size, although the mechanism is unclear...
- Mifepristone Treatment for Cocaine DependenceWILFRED NOEL RABY; Fiscal Year: 2013..Its goal is to test if mifepristone, a central and peripheral glucocorticoid receptor (GR) antagonist, can decrease relapse to cocaine use and ..
- Growth Inhibition Induced by Mifepristone in Ovarian CancerCarlos Telleria; Fiscal Year: 2009..goal of this application is to study the feasibility of using the prototypical progesterone receptor modulator mifepristone, also known as "RU486," for ovarian cancer therapeutics...
- Comparative Effectiveness of Pregnancy Failure Management Regimens (Pre-Fai-R)Courtney A Schreiber; Fiscal Year: 2013..b>Mifepristone, a competitive progesterone and glucocorticoid receptor antagonist, blocks the cellular effects of progesterone ..
- Hormonal Regulation of the Cervix During PregnancyORRIN SHERWOOD; Fiscal Year: 2006..Treatment with RU 486 alone and in combination with exogenous relaxin will be done at term with relaxin-deficient rats. ..
- ANTIPROGESTINS IN ENDOMETRIUMRONALD WIEHLE; Fiscal Year: 2000..Such compounds could fill Zonagen's developmental pipeline with drugs for those diseases and, potentially, other indications. ..
- NEUROENDOCRINE CONTROL OF ANTERIOR PITUITARY HORMONESRHONDA KINEMAN; Fiscal Year: 2006..The current application centers on the interrelationship between changes in metabolic function and the GH axis. ..
- MYOMETRIAL GAP JUNCTION MODULATION IN PRETERM LABORWILLIAM LARSEN; Fiscal Year: 1990..Data obtained in these studies should provide a fundamental basis for the development of new preventative therapies and risk assessment for preterm labor...
- SPECIALIZED CENTER OF RESEARCH IN HEART FAILUREDouglas Mann; Fiscal Year: 2004..These studies elucidate further the molecular foundations of cardiac hypertrophy and failure and should provide a rational basis for more effective therapy. ..
- Antiprogestins in Cynomolgus EndometriosisRONALD WIEHLE; Fiscal Year: 2003..The tertiary outcome parameters will be the assessment of the impact of our compound on inflammation markers, on cycling and on liver function. ..
- ANTIPROGESTINS AND ACTIVE CELL DEATH IN BREAST CANCERM El Etreby; Fiscal Year: 2001..an additive antitumor activity and to clarify the intracellular mechanism of action of the antiprogestin mifepristone, and the antiestrogen tamoxifen, in inhibition of growth of established tumors (chemotherapy) and in prevention ..
- TSH SECRETION--ROLE OF GLUCOCORTICOIDSMary Samuels; Fiscal Year: 1999..2) Administration of mifepristone. Healthy subjects will receive mifepristone, a competitive glucocorticoid antagonist, which will permit a ..
- CSF-1R EXPRESSION IN HUMAN BREAST CARCINOMABARRY KACINSKI; Fiscal Year: 2000..They also propose to determine whether glucocorticoids and their antagonists modulate the expression of CSF-1R in human breast carcinoma specimens maintained ex vivo in short-term organ culture and in vivo in nude mice. ..
- HTS for Androgen Receptor Antagonists that Recruit NCoRSteven Balk; Fiscal Year: 2006..AR can interact with co-repressor proteins, including NCoR and SMRT, and that this interaction is enhanced by mifepristone (RU486), demonstrating that drug induced conformational changes in the AR can enhance co-repressor recruitment...
- Steroid As Cytoprotectants against Oxidative ToxicityQin Chen; Fiscal Year: 2007..The glucocorticoid receptor antagonist mifepristone prevented CT from inducing a cell survival response...
- Collagen-binding proteins in softening of uterine cervixRobert Kokenyesi; Fiscal Year: 2003..in cervical softening will be tested by the induction of preterm delivery with the antiprogesterone agent Mifepristone (RU-486)...
- Control of menstrual bleeding disturbances in womenIan Fraser; Fiscal Year: 2006..There is preliminary evidence that a short course of an antiprogesterone (Mifepristone) may also stabilize the endometrium, and it is postulated that a combination of an antiprogesterone with ..
- PHYSIOLOGIC BASIS OF FA GENE RECESSIVITYGARY TRUETT; Fiscal Year: 1999..2) fa genotype effects can be altered from recessive to codominant by blocking the glucocorticoid receptor with mifepristone early in life from day 8- 16 of life, B...
- Breast Tumor Inhibition by AntiprogestinsRONALD WIEHLE; Fiscal Year: 2002..New antiprogestins discovered by NICHD and realized as drugs through this proposed SBIR, satisfy the need to bring the results of government-sponsored science into the public domain. ..
- HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTIONRoy Freeman; Fiscal Year: 2007..In addition, we will determine whether administration of a glucocorticoid receptor antagonist, mifepristone, prior to antecedent hypoglycemia improves the autonomic and neuroendocrine response to subsequent hypoglycemia ..
- TARGETED OVEREXPRESSION OF PTH-RELATED PEPTIDEARTHUR BROADUS; Fiscal Year: 2007..This aim too is based on preliminary evidence of such an effect in vitro. The model to be created will be a collagen gene-driven Cre under the control of PR1 (RU-486). ..
- METABOLIC CONSEQUENCES OF ANTIRETROVIRAL THERAPYDAVID WEIGLE; Fiscal Year: 2003..Future trials of these medications, along with a great deal more basic research, are clearly justified by the increasing and sustained use of HAART to deal with the worldwide epidemic of HIV infection. ..
- CALCIUM AND SALT INTAKEMICHAEL TORDOFF; Fiscal Year: 1999..For each model, corticosterone and/or RU-486 (a corticosterone antagonist) will be given and several behavioral and physiological parameters assessed. ..
- IMMUNOLOGIC PROBES FOR STUDY OF PROGESTERONE RECEPTORDean Edwards; Fiscal Year: 1991..The overall goal of this proposal is to attempt to relate specific structural features of steroid receptors that might be responsible for regulating functional activities...
- ATF3 in Beta cell signaling, expression & destructionTsonwin Hai; Fiscal Year: 2006..The mifepristone-inducible system will be used to generate transgenic mice expressing ATF3 in the islets in an inducible manner...
- Steroid resistance: Experimental Autoimmune Encephalomyelitis/Multiple SclerosisThomas G Forsthuber; Fiscal Year: 2010..Furthermore, EAE is substantially exacerbated in MIF-/- mice treated with the glucocorticoid receptor inhibitor Mifepristone (RU-486)...
- MYOCARDIAL PROTEIN SYNTHESIS AFTER ALCOHOL INTOXICATIONCharles H Lang; Fiscal Year: 2010..Overall, the research design will establish the mechanism by which myocardial protein synthesis is reduced in response to alcohol abuse. ..
- Antiretroviral-Induced Defects in Muscle Protein SynthesisCharles H Lang; Fiscal Year: 2010..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
- Myocardial Protein Synthesis After Thermal InjuryCharles Lang; Fiscal Year: 2005..Overall, the research will elucidate the mechanisms by which myocardial protein synthesis is reduced after thermal injury, leading to the better understanding and treatment of the resulting cardiomyopathy. - ..
- Progesterone regulation of human luteal cell viabilityJohn Peluso; Fiscal Year: 2006..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. [unreadable] [unreadable]..
- Protein Kinase G Regulation of Granulosa Cell ViabilityJohn Peluso; Fiscal Year: 2006..We now propose to test this hypothesis using biochemical, genetic, imaging and cell biological techniques. [unreadable] [unreadable]..
- The effect of nonoxynol-9 on human endometriumJohn Jain; Fiscal Year: 2005..The results of this study will provide important preliminary information on the role of microbicides on endometrial toxicity and may help guide future research priorities. ..
- RCT of a Novel Oral Contraceptive Initiation MethodCarolyn Westhoff; Fiscal Year: 2004..We will also assess dual method use for STD prevention in the study to adoption of and adherence to oral contraceptives. We will also assess dual method use for STD prevention in the study population. ..
- Regulation of Oocyte Viability by Granulosa Cell ContactJohn Peluso; Fiscal Year: 2004..abstract_text> ..
- MECHANISMS OF REPRODUCTIVE AGINGDarrell Brann; Fiscal Year: 2004..As a whole, the proposed studies will provide important insights as to why glutamate signaling is compromised in the hypothalamus of the middle-aged rat, and will advance our understanding of reproductive aging. ..
- Obesity, Oral Contraception and Ovarian SuppressionCarolyn Westhoff; Fiscal Year: 2007..This study will have very good power to detect clinically important differences. Results could directly and immediately affect contraceptive practice. ..
- ASTROCYTE-NEURON INTERACTIONS AND GNRH NEURONAL FUNCTIONDarrell Brann; Fiscal Year: 2005....
- NEUROENDOCRINE REGULATION OF BEHAVIORJEFFREY BLAUSTEIN; Fiscal Year: 2006....
- Pharmacotherapy for Minor DepressionRobert Howland; Fiscal Year: 2004..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
- LONG-TERM LORAZEPAM USE AND ACUTE TOXICITY IN THE AGEDNunzio Pomara; Fiscal Year: 2005..index of brain white matter organization) contribute most strongly to the acute effects of lorazepam on cognitive/motor performance or postural sway in elderly individuals receiving long-term lorazepam treatment for GAD? ..
- Low birth weight, uterine infection, and nitric oxideChandrasekhar Yallampalli; Fiscal Year: 2007..2 will test the hypothesis that NO donor can reverse the increases in DAF expression in uteroplacental and vascular tissues and in fetal growth restriction ..
- Estrogen receptor activation in the CNSJEFFREY BLAUSTEIN; Fiscal Year: 2005..This initial research is essential for future work on the molecular consequences of ligand independent activation of ERs in the brain of males and females, which can then be studied in an unprecedented way. ..
- Northeast Under/Grad Research Organization for NeuroscienceCheryl Frye; Fiscal Year: 2008..Both of these outcomes are congruous with the Public Health Service's mission to ensure that there is a resource of well-trained scientists and health-care providers in the United States. [unreadable] [unreadable] [unreadable]..
- Arginine and Ovine Model for Fetal Growth RestrictionGuoyao Wu; Fiscal Year: 2007..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. [unreadable] [unreadable] [unreadable]..
- Do Reporting Biases Mitigate Disparity Estimates?Kevin Fiscella; Fiscal Year: 2004..abstract_text> ..
- Progestin Regulation of VEGF in Breast Cancer CellsSALMAN HYDER; Fiscal Year: 2005..abstract_text> ..
- Podocyte Protein Alterations Induced by GlucocorticoidsRichard Ransom; Fiscal Year: 2005..Identification of a potential mechanism for glucocorticoid action in the treatment of NS would permit the development of more highly targeted and less toxic therapies for this very common form of kidney disease. ..
- SYMPATHETIC NEURAL FUNCTION AND GLUCOCORTICOIDSDEBORAH SCHEUER; Fiscal Year: 2001..The results will provide fundamental new knowledge of the mechanisms of glucocorticoid-mediated modulation of arterial pressure regulation. ..
- Simplified Tai Chi for Reducing Fibromyalgia PainCHRISTY SHERMAN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..