testosterone

Summary

Summary: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.

Top Publications

  1. ncbi Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays
    Lam P Ly
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney NSW 2139, Australia
    Eur J Endocrinol 152:471-8. 2005
  2. pmc Adverse events associated with testosterone administration
    Shehzad Basaria
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
    N Engl J Med 363:109-22. 2010
  3. ncbi Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    Michael Stanbrough
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2815-25. 2006
  4. pmc Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group
    Howard I Scher
    Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    J Clin Oncol 26:1148-59. 2008
  5. ncbi Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study
    Henry A Feldman
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 87:589-98. 2002
  6. ncbi A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    C W Gregory
    Laboratory for Reproductive Biology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Res 61:4315-9. 2001
  7. doi Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline
    Shalender Bhasin
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:2536-59. 2010
  8. doi Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis
    M Mercè Fernández-Balsells
    Knowledge and Encounter Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 95:2560-75. 2010
  9. doi Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study
    Upendram Srinivas-Shankar
    Andrology Research Unit, Department of Medicine and Endocrinology, University of Manchester, Manchester Royal Infirmary, Grafton Street, Manchester, United Kingdom M13 9WL
    J Clin Endocrinol Metab 95:639-50. 2010
  10. ncbi Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging
    S M Harman
    The Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 86:724-31. 2001

Research Grants

  1. TESTOSTERONE EFFECTS ON DIAPHRAGM MUSCLE FATIGUE
    Cesar Blanco; Fiscal Year: 2002
  2. ANDROGEN AS ADJUNCT THERAPY IN RHEUMATOID ARTHRITIS
    John Davis; Fiscal Year: 2002
  3. The Molecular Basis of Ovarian Testosterone Production
    Robert Rosenfield; Fiscal Year: 2004
  4. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
  5. Yun Fai Chris Lau; Fiscal Year: 2014
  6. Ashraf Gorgey; Fiscal Year: 2016
  7. NICOLE RENEE TARTAGLIA; Fiscal Year: 2015
  8. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
  9. Epigenetics of Sex Differences in Brain and Behavior
    BRIDGET NUGENT; Fiscal Year: 2012
  10. John H Postlethwait; Fiscal Year: 2016

Detail Information

Publications387 found, 100 shown here

  1. ncbi Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays
    Lam P Ly
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney NSW 2139, Australia
    Eur J Endocrinol 152:471-8. 2005
    The growing interest in measuring blood free testosterone (FT) is constrained by the unsuitability of the laborious reference methods for wider adoption in routine diagnostic laboratories...
  2. pmc Adverse events associated with testosterone administration
    Shehzad Basaria
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts 02118, USA
    N Engl J Med 363:109-22. 2010
    b>Testosterone supplementation has been shown to increase muscle mass and strength in healthy older men. The safety and efficacy of testosterone treatment in older men who have limitations in mobility have not been studied.
  3. ncbi Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    Michael Stanbrough
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Cancer Res 66:2815-25. 2006
    ..aldo-keto reductase family 1, member C3 (AKR1C3), the prostatic enzyme that reduces adrenal androstenedione to testosterone, was confirmed by real-time reverse transcription-PCR and immunohistochemistry...
  4. pmc Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group
    Howard I Scher
    Genitourinary Oncology Service, Department of Medicine, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065, USA
    J Clin Oncol 26:1148-59. 2008
    To update eligibility and outcome measures in trials that evaluate systemic treatment for patients with progressive prostate cancer and castrate levels of testosterone.
  5. ncbi Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study
    Henry A Feldman
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 87:589-98. 2002
    ..The paradoxical finding that longitudinal age trends were steeper than cross-sectional trends suggests that incident poor health may accelerate the age-related decline in androgen levels...
  6. ncbi A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy
    C W Gregory
    Laboratory for Reproductive Biology, Department of Pediatrics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Res 61:4315-9. 2001
    ..depends on the androgen receptor and its high-affinity binding of dihydrotestosterone, which derives from testosterone. Most prostate tumors regress after therapy to prevent testosterone production by the testes, but the tumors ..
  7. doi Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline
    Shalender Bhasin
    Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 95:2536-59. 2010
    ..Our objective was to update the guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men published previously in 2006...
  8. doi Clinical review 1: Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis
    M Mercè Fernández-Balsells
    Knowledge and Encounter Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 95:2560-75. 2010
    The risks of testosterone therapy in men remain poorly understood.
  9. doi Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study
    Upendram Srinivas-Shankar
    Andrology Research Unit, Department of Medicine and Endocrinology, University of Manchester, Manchester Royal Infirmary, Grafton Street, Manchester, United Kingdom M13 9WL
    J Clin Endocrinol Metab 95:639-50. 2010
    Physical frailty is associated with reduced muscle strength, impaired physical function, and quality of life. Testosterone (T) increases muscle mass and strength in hypogonadal patients...
  10. ncbi Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging
    S M Harman
    The Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 86:724-31. 2001
    Many studies have shown cross-sectional (and two small studies, longitudinal) declines in total and/or free testosterone (T) levels, with age, in men...
  11. pmc Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells
    Wei Lin W Wang
    Department of Biomedical Sciences, University at Albany, State University of New York, Albany, NY 12222, USA
    Mol Cancer 10:58. 2011
    There is evidence from epidemiological and in vitro studies that the biological effects of testosterone (T) on cell cycle and survival are modulated by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in prostate cancer...
  12. doi Comparison of serum testosterone and estradiol measurements in 3174 European men using platform immunoassay and mass spectrometry; relevance for the diagnostics in aging men
    Ilpo T Huhtaniemi
    Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, UK
    Eur J Endocrinol 166:983-91. 2012
    The limitations of serum testosterone and estradiol (E(2)) measurements using non-extraction platform immunoassays (IAs) are widely recognized...
  13. pmc Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 72:839-47. 2012
    ..One potential mechanism underlying such observations is testosterone in early development...
  14. doi Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels
    Rebecca Vigen
    The University of Texas at Southwestern Medical Center, Dallas
    JAMA 310:1829-36. 2013
    Rates of testosterone therapy are increasing and the effects of testosterone therapy on cardiovascular outcomes and mortality are unknown...
  15. doi Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo-controlled Moscow study
    Svetlana Y Kalinchenko
    The Faculty of Medical Staff Refresher Training, People s Friendship University of Russia Medical Clinic of Reproduction MAMA, Moscow, Russia
    Clin Endocrinol (Oxf) 73:602-12. 2010
    Men with the metabolic syndrome (MetS) have low plasma testosterone (T) levels. The aim of this study was to establish whether the normalization of plasma T improves the features of the MetS.
  16. ncbi Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 27:1036-41. 2004
    ..We assessed the association of low levels of testosterone and sex hormone-binding globulin (SHBG) with the development of the metabolic syndrome and diabetes in men.
  17. doi Low testosterone in men with type 2 diabetes: significance and treatment
    Mathis Grossmann
    Department of Medicine, Austin Health Northern Health, University of Melbourne, Heidelberg, VIC 3084, Australia
    J Clin Endocrinol Metab 96:2341-53. 2011
    The relationship between testosterone and diabetes in men is an important issue, given that one third of U.S. men aged 65 yr or older have diabetes, with a similar percentage having low testosterone levels.
  18. ncbi In men older than 70 years, total testosterone remains stable while free testosterone declines with age. The Health in Men Study
    Bu B Yeap
    School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia
    Eur J Endocrinol 156:585-94. 2007
    An age-related decline in serum total and free testosterone concentration may contribute to ill health in men, but limited data are available for men > 70 years of age...
  19. pmc Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
    Michelle Welsh
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    J Clin Invest 118:1479-90. 2008
    ..Based on the timings in rats, we believe the programming window in humans is likely to be 8-14 weeks of gestation...
  20. doi Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study
    Gideon Sartorius
    Andrology Department, Concord Hospital, Clayton, Vic, Australia
    Clin Endocrinol (Oxf) 77:755-63. 2012
    To determine serum concentrations, intra-individual variability and impact of age-related co-morbidities on serum testosterone (T), dihydrotestosterone (DHT), estradiol (E(2)) and estrone (E(1)) in older men.
  21. doi Reference ranges and determinants of testosterone, dihydrotestosterone, and estradiol levels measured using liquid chromatography-tandem mass spectrometry in a population-based cohort of older men
    Bu B Yeap
    School of Medicine and Pharmacology, Level 2, T Block, Fremantle Hospital, Alma Street, Fremantle, Western Australia 6160, Australia
    J Clin Endocrinol Metab 97:4030-9. 2012
    b>Testosterone (T) levels decline with increasing age. Controversy exists over the threshold for classifying T as low vs. normal in older men. The relevance of assessing dihydrotestosterone (DHT) and estradiol (E2) remains unclear.
  22. pmc Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials
    Lin Xu
    School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China
    BMC Med 11:108. 2013
    b>Testosterone therapy is increasingly promoted...
  23. ncbi Kiss1-/- mice exhibit more variable hypogonadism than Gpr54-/- mice
    Risto Lapatto
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Endocrinology 148:4927-36. 2007
    ..Kiss1 knockout females demonstrate a bimodal phenotypic variability, with some animals having higher gonadal weight, larger vaginal opening, and persistent vaginal cornification...
  24. doi Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial
    Marielle H Emmelot-Vonk
    Department of Geriatric Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    JAMA 299:39-52. 2008
    Serum testosterone levels decline significantly with aging. Testosterone supplementation to older men might beneficially affect the aging processes.
  25. pmc Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer
    Kai Hsiung Chang
    Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8852, USA
    Proc Natl Acad Sci U S A 108:13728-33. 2011
    ..of cases, advanced prostate cancer responds initially to androgen deprivation therapy by depletion of gonadal testosterone. The response is usually transient, and metastatic tumors almost invariably eventually progress as castration-..
  26. ncbi Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy
    Masahisa Katsuno
    Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Japan
    Neuron 35:843-54. 2002
    ..Female transgenic mice showed only a few manifestations that markedly deteriorated with testosterone administration...
  27. ncbi Testosterone and dominance in men
    A Mazur
    Public Affairs Program, Syracuse University, NY 13244, USA
    Behav Brain Sci 21:353-63; discussion 363-97. 1998
    In men, high levels of endogenous testosterone (T) seem to encourage behavior intended to dominate--to enhance one's status over--other people...
  28. ncbi Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials
    Olga M Calof
    Boston University, School of Medicine, E201, 88 E Newton Street, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 60:1451-7. 2005
    We performed a meta-analysis of randomized clinical trials to determine the risks of adverse events associated with testosterone replacement in older men.
  29. doi The role of testosterone in social interaction
    Christoph Eisenegger
    Behavioral and Clinical Neuroscience Institute, Department of Experimental Psychology, Downing Street, University of Cambridge, CB2 3EB, UK
    Trends Cogn Sci 15:263-71. 2011
    Although animal researchers established the role of testosterone as a 'social hormone' decades ago, the investigation of its causal influence on human social behaviors has only recently begun...
  30. ncbi Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos
    D Dai
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 299:825-31. 2001
    ..b>Testosterone and the insecticide chlorpyrifos were used to assess the catalytic activities of the most common CYP3A4 allele (..
  31. ncbi Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry
    Christina Wang
    Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90502, USA
    J Clin Endocrinol Metab 89:534-43. 2004
    The diagnosis of male hypogonadism requires the demonstration of a low serum testosterone (T) level...
  32. ncbi Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction
    Toru Takeuchi
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
    Endocr J 51:165-9. 2004
    ..There were significant positive correlations between serum BPA and total testosterone (r = 0.391, p<0.001), free testosterone (r = 0.504, p<0.001), androstenedione (r = 0.684, p<0...
  33. ncbi Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial
    J Svartberg
    Department of Medicine, University Hospital of North Norway, N 9038 Tromsø, Norway
    Respir Med 98:906-13. 2004
    The aim of this study was to assess the effect of a low-dose testosterone on body composition and pulmonary function, as well as on quality of life, sexuality, and psychological symptoms in patients with chronic obstructive pulmonary ..
  34. ncbi Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer
    Elahe A Mostaghel
    Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Cancer Res 67:5033-41. 2007
    ..Medical castration based on serum testosterone levels cannot be equated with androgen ablation in the prostate microenvironment...
  35. doi Androgens inhibit androgen receptor promoter activation in motor neurons
    Guglielmo Vismara
    Department of Endocrinology, Pathophysiology and Applied Biology Center of Excellence on Neurodegenerative Diseases of the University of Milan Via Balzaretti 9, 20133, Italy
    Neurobiol Dis 33:395-404. 2009
    ..b>Testosterone, dihydrotestosterone (DHT), but not estradiol, inhibited AR promoter activation...
  36. pmc Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer
    Gerhardt Attard
    Royal Marsden National Health Service Foundation Trust, Sutton, Surrey, United Kingdom
    J Clin Oncol 27:3742-8. 2009
    ..Abiraterone acetate is a potent, selective, and orally available inhibitor of CYP17, the key enzyme in androgen and estrogen biosynthesis...
  37. doi Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study
    Abdelouahid Tajar
    The University of Manchester, Manchester Academic Health Science Centre, Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
    J Clin Endocrinol Metab 95:1810-8. 2010
    The diagnosis of late-onset hypogonadism (LOH) in older men with age-related declines in testosterone (T) is currently not well characterized.
  38. doi Type 2 diabetes mellitus and testosterone: a meta-analysis study
    G Corona
    Andrology Unit and Endocrinology, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Int J Androl 34:528-40. 2011
    ..Despite the well-known link, the role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified...
  39. pmc Testosterone replacement in hypogonadal men with type 2 diabetes and/or metabolic syndrome (the TIMES2 study)
    T Hugh Jones
    The Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital, Barnsley, UK
    Diabetes Care 34:828-37. 2011
    This study evaluated the effects of testosterone replacement therapy (TRT) on insulin resistance, cardiovascular risk factors, and symptoms in hypogonadal men with type 2 diabetes and/or metabolic syndrome (MetS).
  40. doi Testosterone, cardiovascular disease and the metabolic syndrome
    Giovanni Corona
    Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Best Pract Res Clin Endocrinol Metab 25:337-53. 2011
    Recent evidence suggests that low, rather than high, testosterone (T) is associated with increased male morbidity and mortality...
  41. pmc Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart study
    Shalender Bhasin
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA, USA
    Diabetes Care 34:2464-70. 2011
    The association between total testosterone and metabolic syndrome has prompted speculation that low testosterone contributes to the pathophysiology of metabolic syndrome in men...
  42. pmc Testosterone inhibits transforming growth factor-β signaling during myogenic differentiation and proliferation of mouse satellite cells: potential role of follistatin in mediating testosterone action
    Melissa Braga
    Division of Endocrinology and Metabolism, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, United States
    Mol Cell Endocrinol 350:39-52. 2012
    b>Testosterone (T) administration is associated with increased satellite cell number and skeletal muscle hypertrophy, although there is considerable heterogeneity in the response of different skeletal muscle groups to T in vivo...
  43. doi Testosterone treatment and mortality in men with low testosterone levels
    Molly M Shores
    Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, S 116PES, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 97:2050-8. 2012
    Low testosterone levels in men have been associated with increased mortality. However, the influence of testosterone treatment on mortality in men with low testosterone levels is not known.
  44. doi Antiinflammatory effect of androgen receptor activation in human benign prostatic hyperplasia cells
    Linda Vignozzi
    Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence 50139, Italy
    J Endocrinol 214:31-43. 2012
    ..demonstrated that prostate inflammation and tissue remodeling are exacerbated by hypogonadism and prevented by testosterone supplementation...
  45. ncbi Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
    Mark A Titus
    Department of Pathology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, 27599 7295, USA
    Clin Cancer Res 11:4653-7. 2005
    ..Many groups have pursued mechanisms of ligand-independent androgen receptor activation but we found high levels of testicular androgens in recurrent prostate cancer tissue using RIA...
  46. pmc Association of sex hormones and C-reactive protein levels in men
    Varant Kupelian
    New England Research Institutes, Watertown, MA 02472, USA
    Clin Endocrinol (Oxf) 72:527-33. 2010
    ..The objective of this analysis was to investigate the association between sex hormone levels and C-reactive protein (CRP) in a population-based sample of men...
  47. ncbi Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941
    Charles Huggins
    J Urol 168:9-12. 2002
  48. pmc Changes in muscle mass, muscle strength, and power but not physical function are related to testosterone dose in healthy older men
    Thomas W Storer
    Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA
    J Am Geriatr Soc 56:1991-9. 2008
    To examine the effect of graded doses of testosterone on physical function and muscle performance in healthy, older men.
  49. doi Growth of white matter in the adolescent brain: role of testosterone and androgen receptor
    Jennifer S Perrin
    Brain and Body Centre, University of Nottingham, Nottingham NG72RD, United Kingdom
    J Neurosci 28:9519-24. 2008
    ..Here, we provide evidence supporting the role of androgen receptor (AR) in mediating the effect of testosterone on white matter...
  50. pmc Genetic determinants of serum testosterone concentrations in men
    Claes Ohlsson
    Center for Bone and Arthritis Research, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
    PLoS Genet 7:e1002313. 2011
    b>Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity...
  51. ncbi Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons
    J Hammond
    Bloomfield Center for Research in Aging, The Lady Davis Institute for Medical Research, Sir Mortimer B Davis, Jewish General Hospital, Montreal, Quebec, Canada
    J Neurochem 77:1319-26. 2001
    ..To determine if male hormones could also be neuroprotective, we investigated the effect of testosterone, methyltestosterone, and epitestosterone at physiological concentrations on primary cultures of human neurons ..
  52. ncbi Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats
    Mahitosh Sarkar
    Reproductive Physiology Unit, Dept of Physiology, University Colleges of Science and Technology, Calcutta University, 92 Acharya Prafulla Chandra Road, Calcutta 700009, India
    Asian J Androl 5:27-31. 2003
    ..To investigate the effect of arsenic on spermatogenesis...
  53. ncbi 2nd to 4th digit ratios, fetal testosterone and estradiol
    S Lutchmaya
    Developmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK
    Early Hum Dev 77:23-8. 2004
    ..There is indirect evidence that 2D:4D is established in utero and is negatively related to prenatal testosterone and positively with prenatal estradiol...
  54. ncbi The relationship between testosterone and molecular markers of inflammation in older men
    M Maggio
    Longitudinal Studies Section, Clinical Research Branch, CRB, National Institute on Aging, NIA, USA
    J Endocrinol Invest 28:116-9. 2005
    ..At the same time, aging is associated with a decrease in serum testosterone (T) levels...
  55. doi Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction
    Abdulmaged M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, MA 02118, USA
    FEBS J 276:5755-67. 2009
    ..Furthermore, obesity is also associated with reduced plasma testosterone levels, which contributes to hypogonadism and increases the risk of vascular pathology...
  56. ncbi Testosterone dose-response relationships in healthy young men
    S Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 281:E1172-81. 2001
    b>Testosterone increases muscle mass and strength and regulates other physiological processes, but we do not know whether testosterone effects are dose dependent and whether dose requirements for maintaining various androgen-dependent ..
  57. pmc Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues
    Shuyuan Yeh
    Departments of Urology and Pathology, George H Whipple Lab for Cancer Research, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 99:13498-503. 2002
    ..Their testes are 80% smaller and serum testosterone concentrations are lower than in wild-type (wt) mice. Spermatogenesis is arrested at pachytene spermatocytes...
  58. ncbi The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men
    Chris J Malkin
    Cardiology Department, Royal Hallamshire Hospital, Sheffield, United Kingdom S10 2JF
    J Clin Endocrinol Metab 89:3313-8. 2004
    b>Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNFalpha, IL-1beta, and IL-6 and potentiate the expression of the ..
  59. ncbi Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
    Stephanie T Page
    Wesley Woods Health Center, 1841 Clifton Road Northeast, Atlanta, Georgia 30329 5102, USA
    J Clin Endocrinol Metab 90:1502-10. 2005
    b>Testosterone (T) therapy in older men with low serum T levels increases lean body mass and decreases fat mass...
  60. ncbi Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis
    Andrea M Isidori
    Cattedra di Andrologia, Universita La Sapienza, Rome, Italy
    Clin Endocrinol (Oxf) 63:280-93. 2005
    Ageing in men is associated with a gradual decline in serum testosterone levels and a concomitant loss of muscle mass, accumulation of central adiposity, impaired mobility and increased risk of bone fractures...
  61. ncbi Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism
    Jenny Jakobsson
    Clinical Pharmacology, C1 68, Karolinska Institutet at Karolinska University Hospital, S 141 86 Stockholm, Sweden
    J Clin Endocrinol Metab 91:687-93. 2006
    ..Uridine diphosphoglucuronosyl transferases have a key role in the homeostasis and metabolism of androgens. Recently a deletion polymorphism was detected in the UGT2B17 gene...
  62. ncbi Testosterone and human aggression: an evaluation of the challenge hypothesis
    John Archer
    Department of Psychology, University of Central Lancashire, Preston, Lancashire PR12HE, UK
    Neurosci Biobehav Rev 30:319-45. 2006
    Research on testosterone-behavior relationships in humans is assessed in relation to a version of the challenge hypothesis, originally proposed to account for testosterone-aggression associations in monogamous birds...
  63. doi Identification of late-onset hypogonadism in middle-aged and elderly men
    Frederick C W Wu
    Andrology Research Unit, Developmental and Regenerative Biomedicine Research Group, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
    N Engl J Med 363:123-35. 2010
    The association between aging-related testosterone deficiency and late-onset hypogonadism in men remains a controversial concept...
  64. pmc Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, low bone mass, and physical frailty
    Anne M Kenny
    Center on Aging, MC 5215, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Am Geriatr Soc 58:1134-43. 2010
    To investigate the effects of testosterone supplementation on bone, body composition, muscle, physical function, and safety in older men.
  65. doi Testosterone and metabolic syndrome: a meta-analysis study
    Giovanni Corona
    Andrology and Sexual Medicine Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Sex Med 8:272-83. 2011
    Metabolic syndrome (MetS) is often associated with male hypogonadism. Despite the well-known link, the role of testosterone replacement therapy (TRT) in MetS has not been completely clarified.
  66. ncbi Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
    b>Testosterone supplementation increases skeletal muscle mass and decreases fat mass; however, the underlying mechanisms are unknown...
  67. ncbi Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer
    Motohide Uemura
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Shirokanedai 4 6 1 Minato ku, Tokyo 108 8639, Japan
    Cancer Sci 99:81-6. 2008
    ..5 alpha-steroid reductase that produces the most potent androgen, 5 alpha-dihydrotestosterone (DHT), from testosterone. Liquid chromatography-tandem mass spectrometry analysis following an in vitro 5 alpha-steroid reductase ..
  68. ncbi Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    D Kapoor
    Centre for Diabetes and Endocrinology, Barnsley NHS Foundation Trust Hospital, Gawber Road, Barnsley S75 2EP, UK
    Eur J Endocrinol 154:899-906. 2006
    Low levels of testosterone in men have been shown to be associated with type 2 diabetes, visceral adiposity, dyslipidaemia and metabolic syndrome...
  69. ncbi The mismatch effect: when testosterone and status are at odds
    Robert A Josephs
    Department of Psychology, The University of Texas at Austin, USA
    J Pers Soc Psychol 90:999-1013. 2006
    ..studies, the authors examined the psychological and physiological consequences of a mismatch between baseline testosterone and a person's current level of status...
  70. pmc Non-genomic actions of androgens
    C D Foradori
    Department of Biomedical Sciences, Neurobiology Section, Colorado State University, Fort Collins, CO 80523, USA
    Front Neuroendocrinol 29:169-81. 2008
    ..and neuroendocrine fields has viewed the androgen receptor (AR) as a transcription factor activated by testosterone or one of its many metabolites...
  71. doi Testosterone and type 2 diabetes
    Mathis Grossmann
    Department of Medicine, Austin Health Northern Health, University of Melbourne, Heidelberg, Victoria, Australia
    Curr Opin Endocrinol Diabetes Obes 17:247-56. 2010
    To describe the relationship between testosterone levels and type 2 diabetes (T2D).
  72. doi Inhibition of human and rat testicular steroidogenic enzyme activities by bisphenol A
    Leping Ye
    The 2nd Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
    Toxicol Lett 207:137-42. 2011
    Bisphenol A (BPA) is a potential endocrine disruptor. It has been shown that it reduces serum testosterone level in rodents after exposure. However, the mechanism is unclear...
  73. ncbi Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men
    A W van den Beld
    Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands
    J Clin Endocrinol Metab 85:3276-82. 2000
    ..in bone mass, body composition, and muscle strength with age are related to the fall in circulating endogenous testosterone (T) and estrogen concentrations...
  74. pmc Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratio
    Jack van Honk
    Department of Experimental Psychology, Utrecht University, 3584 CS, Utrecht The Netherlands
    Proc Natl Acad Sci U S A 108:3448-52. 2011
    ..Females on average outperform males in this cognitive empathy, and the male sex hormone testosterone is thought to be involved...
  75. pmc Clinical review: Endogenous testosterone and mortality in men: a systematic review and meta-analysis
    Andre B Araujo
    Department of Epidemiology, New England Research Institutes, Inc, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 96:3007-19. 2011
    Low testosterone levels have been associated with outcomes that reduce survival in men.
  76. ncbi Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 82:863-70. 2004
    ..To examine the relationship between body mass index (BMI) and semen quality among young men from the general population...
  77. pmc Testosterone decreases trust in socially naive humans
    Peter A Bos
    Department of Psychology, Utrecht University, 3584 CS, Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 107:9991-5. 2010
    ..b>Testosterone, a steroid hormone associated with competition and dominance, is often viewed as an inhibitor of sociality, and ..
  78. doi Sex-specific associations between umbilical cord blood testosterone levels and language delay in early childhood
    Andrew J O Whitehouse
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, WA 6008, Australia
    J Child Psychol Psychiatry 53:726-34. 2012
    Preliminary evidence suggests that prenatal testosterone exposure may be associated with language delay. However, no study has examined a large sample of children at multiple time-points.
  79. doi Dietary green and white teas suppress UDP-glucuronosyltransferase UGT2B17 mediated testosterone glucuronidation
    Carl Jenkinson
    School of Life Sciences, Kingston University, London, UK
    Steroids 77:691-5. 2012
    The anabolic steroid testosterone can be used by athletes to enhance athletic performance and muscle growth...
  80. ncbi Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty, and follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol levels
    A M Andersson
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Clin Endocrinol Metab 82:3976-81. 1997
    ..In addition, serum levels of FSH, LH, testosterone, and estradiol levels were measured...
  81. doi The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistance
    Abdulamaged M Traish
    Department of Biochemistry and Urology, Boston University School of Medicine, Boston, MA 02118, USA
    J Androl 30:23-32. 2009
    A considerable body of evidence exists suggesting a link among reduced testosterone plasma levels, type 2 diabetes (T2D), and insulin resistance (IR). Hypogonadal men are at higher risk for T2D...
  82. ncbi Increased incidence of diagnosed depressive illness in hypogonadal older men
    Molly M Shores
    Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Arch Gen Psychiatry 61:162-7. 2004
    Age-associated hypogonadism (testosterone deficit) occurs in 30% of men after the age of 55; it is associated with decreased muscle mass, bone mineral density, and libido, and with anorexia, fatigue, and irritability...
  83. ncbi Attentional, emotional and hormonal data in subjects of different ages
    Giuliano Fontani
    Dipartimento di Fisiologia, Sezione di Neuroscienze e Fisiologia Applicata, Universita di Siena, Via A Moro 3, 53100, Siena, Italy
    Eur J Appl Physiol 92:452-61. 2004
    ..Emotionality was assessed on the basis of skin conductance, heart rate and frontalis muscle tone. Testosterone (T), free testosterone (fT), non-specifically bound testosterone (NST), sex hormone binding globulin (sHBG), ..
  84. ncbi Testosterone replacement therapy: current trends and future directions
    E Nieschlag
    Institute of Reproductive Medicine of the University Domagkstr 11, D 48129 Munster, Germany
    Hum Reprod Update 10:409-19. 2004
    Male hypogonadism is characterized by abnormally low serum testosterone levels associated with typical symptoms, including mood disturbance, sexual dysfunction, decreased muscle mass and strength, and decreased bone mineral density...
  85. ncbi Protective effect of testosterone on early apoptotic damage induced by streptozotocin in rat pancreas
    S Morimoto
    Instituto Nacional de Ciencias Medicas y Nutricion, SZ Vasco de Quiroga 15, Tlalpan 14000, D F Mexico, Mexico
    J Endocrinol 187:217-24. 2005
    ..present study was to investigate the early apoptotic damage induced by STZ in rat pancreas, and the effect of testosterone in preventing apoptosis of pancreatic beta cells...
  86. ncbi Fetal programming: prenatal testosterone treatment leads to follicular persistence/luteal defects; partial restoration of ovarian function by cyclic progesterone treatment
    Mohan Manikkam
    Department of Pediatrics, University of Michigan, Ann Arbor, 48109 0404, USA
    Endocrinology 147:1997-2007. 2006
    Prenatal testosterone (T) excess during midgestation leads to estrous cycle defects and polycystic ovaries in sheep...
  87. ncbi The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men
    Thomas G Travison
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 92:549-55. 2007
    Although it is known that serum testosterone (T) concentrations decline with age, the relative contributions of changes in health and lifestyle to that decline have not been adequately assessed.
  88. doi A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner
    Kembra L Howdeshell
    Reproductive Toxicology Division, NHEERL, ORD, United States Environmental Protection Agency USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 105:153-65. 2008
    ..benzylbutyl phthalate (BBP), di(n)butyl phthalate (DBP), and diethylhexyl phthalate (DEHP) decreases testicular testosterone production and insulin-like 3 hormone mRNA levels...
  89. pmc Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways
    Ekaterina L Kovacheva
    Division of Endocrinology, Charles R Drew University, Los Angeles, California 90059, USA
    Endocrinology 151:628-38. 2010
    Aging in rodents and humans is characterized by loss of muscle mass (sarcopenia). Testosterone supplementation increases muscle mass in healthy older men...
  90. doi Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation
    Jenny Jakobsson Schulze
    Clinical Pharmacology C1 68, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Clin Endocrinol Metab 93:2500-6. 2008
    b>Testosterone abuse is conventionally assessed by the urinary testosterone/epitestosterone (T/E) ratio, levels above 4.0 being considered suspicious...
  91. doi Testosterone and depression: systematic review and meta-analysis
    Fahd Aziz Zarrouf
    West Virginia University School of Medicine, Charleston Division, WV, USA
    J Psychiatr Pract 15:289-305. 2009
    Studies suggest that testosterone (TT) replacement may have an antidepressant effect in depressed patients.
  92. ncbi Dysmetabolic syndrome in a man with a novel mutation of the aromatase gene: effects of testosterone, alendronate, and estradiol treatment
    Laura Maffei
    Consultorios Asociados de Endocrinologia, 1425 Buenos Aires, Argentina
    J Clin Endocrinol Metab 89:61-70. 2004
    ..The analysis of the effects induced by the successive treatment with high doses of testosterone, alendronate, and estradiol allows further insight into the roles of androgens and estrogens on several ..
  93. ncbi Reproductive effects in male rats exposed to diuron
    Glaura S A Fernandes
    Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    Reprod Toxicol 23:106-12. 2007
    ..reproductive organ, liver and kidney weights; measurement of diuron concentrations in liver and kidney; plasma testosterone determinations; evaluation of daily sperm production per testis; sperm number and sperm transit time in the ..
  94. ncbi Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system
    J E Nestler
    Department of Internal Medicine, Medical College of Virginia Virginia Commonwealth University, Richmond 23298, USA
    J Clin Endocrinol Metab 83:2001-5. 1998
    To determine whether insulin stimulates human ovarian testosterone production in the polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system, thecal cells from ..
  95. ncbi Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males
    Waljit S Dhillo
    Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 90:6609-15. 2005
    ..The endogenous neuropeptide agonist for G protein-coupled receptor 54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal axis in rodents and primates...
  96. pmc Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men
    Chaoyang Li
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 33:1618-24. 2010
    ..We sought to assess the associations of testosterones and sex hormone-binding globulin (SHBG) with metabolic syndrome and insulin resistance in men...
  97. doi Effects of exogenous testosterone on the ventral striatal BOLD response during reward anticipation in healthy women
    Erno J Hermans
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Neuroimage 52:277-83. 2010
    Correlational evidence in humans shows that levels of the androgen hormone testosterone are positively related to reinforcement sensitivity and competitive drive...
  98. ncbi Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study
    Andre B Araujo
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 89:5920-6. 2004
    ..Data on androgen deficiency (defined using both signs/symptoms plus total and calculated free testosterone) were available for n = 1691 (baseline) and n = 1087 (follow-up) men from the Massachusetts Male Aging Study...
  99. ncbi Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement
    William Rosner
    St Luke s Roosevelt Hospital Center, 1000 Tenth Avenue, AJA 403, New York, New York 10019, USA
    J Clin Endocrinol Metab 92:405-13. 2007
    The objective of the study was to evaluate the current state of clinical assays for total and free testosterone.
  100. pmc Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice
    Ruey Sheng Wang
    Department of Pathology and Urology, George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Endocr Rev 30:119-32. 2009
    ....
  101. doi Testosterone increases amygdala reactivity in middle-aged women to a young adulthood level
    Guido A van Wingen
    FC Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
    Neuropsychopharmacology 34:539-47. 2009
    b>Testosterone modulates mood and sexual function in women. However, androgen levels decline with age, which may relate to the age-associated change in sexual functioning and the prevalence of mood and anxiety disorders...

Research Grants83

  1. TESTOSTERONE EFFECTS ON DIAPHRAGM MUSCLE FATIGUE
    Cesar Blanco; Fiscal Year: 2002
    DESCRIPTION (Adapted from the applicant's abstract): Anabolic-androgenic steroids (AAS), such as testosterone, are used to increase mass and strength...
  2. ANDROGEN AS ADJUNCT THERAPY IN RHEUMATOID ARTHRITIS
    John Davis; Fiscal Year: 2002
    ..A hypogonadic condition characterized by low serum testosterone has been previously described in male RA patients compared with age-matched controls with osteoarthritis, ..
  3. The Molecular Basis of Ovarian Testosterone Production
    Robert Rosenfield; Fiscal Year: 2004
    ..and anovulation which appears to be due to dysregulation of steroidogenesis resulting in a high level of serum testosterone. Testosterone biosynthesis from androstenedione is carried out by androgenic 17b-hydroxysteroid dehydrogenase (..
  4. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    ..Leydig cells are the predominant source of the male sex steroid hormone testosterone. Approximately 15% of infants fed soy-based formulas in the United States each year are exposed to the ..
  5. Yun Fai Chris Lau; Fiscal Year: 2014
    ..Hence, the X-gene is a tumor suppressor gene. We show that these two sex chromosome genes can affect testosterone (male-hormone) associated physiology, again in opposing directions...
  6. Ashraf Gorgey; Fiscal Year: 2016
    ..It is also unknown whether enhancing the decline anabolic homeostasis by providing testosterone (T) replacement therapy (TRT) would reverse body composition and metabolic profile changes in veterans with SCI...
  7. NICOLE RENEE TARTAGLIA; Fiscal Year: 2015
    ..b>Testosterone deficiency develops during adolescence in the majority of affected males, but objective data about the ..
  8. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..It is now widely recognized that testosterone (T) is an androgenic precursor of the more potent 5[unreadable]-dihydrotestosterone (DHT), produced by 5[..
  9. Epigenetics of Sex Differences in Brain and Behavior
    BRIDGET NUGENT; Fiscal Year: 2012
    ..that DNMT enzyme inhibition during the perinatal critical period will result in masculinized sex behavior in testosterone-primed adult female rats...
  10. John H Postlethwait; Fiscal Year: 2016
    ..signal that promotes, in surrounding somatic cells, 3) the production of aromatase, the enzyme that 4) converts testosterone to estrogen, which preserves oocytes and biases the gonad toward a female fate;5) with insufficient quantities ..
  11. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..is that sex differences in adult hormonal stress responses are primarily the result of the opposing actions of testosterone (T) and estrogen (E) on HPA function...
  12. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    ..then to identify effective temporal profiles for 5 other soluble regulators of MuSCs and their progeny (Wnt7a, testosterone, HGF, Wnt3a inhibitor, and MGF)...
  13. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..plasma stored from the baseline data collection and 2 years after randomization, we propose to examine ESH (testosterone, estradiol, sex hormone binding globulin) and follicle stimulating hormone (FSH) in a subset of DPP women ..
  14. Lucy A Waskell; Fiscal Year: 2014
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
  15. Henryk F Urbanski; Fiscal Year: 2014
    ..In men, increasing age also results in significant perturbations in the levels of circulating androgens (testosterone and dehydroepiandrosterone (DHEA)), which has been linked to sarcopenia, osteoporosis, cardiovascular disease ..
  16. CRAIG STEPHEN ATWOOD; Fiscal Year: 2014
    ..relevant sex steroids: women treated with E2 (3 controlled/1 uncontrolled studies) and men treated with testosterone (T;2 controlled studies), 3) the abrupt cognitive deficits observed in premenopausal women following '..
  17. DONNA LORRAINE WHITE; Fiscal Year: 2014
    ..Experimental data suggests the AR and also its androgen ligands including the primary male sex hormone testosterone may play a role in increasing risk of liver cancer due to another viral infection, Hepatitis B virus...
  18. Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
    MELISSA ANN BROWN; Fiscal Year: 2013
    ..This is not due to disparate serum testosterone levels between wild type and ckitW/Wv males, which show no significant differences...
  19. Melinda Sheffield-Moore; Fiscal Year: 2014
    ..More recently, we found that 3 months of testosterone therapy downregulates ubiquitin and the E3 ubiquitin ligases MuRF1 and MAFbx/Atrogin-1 gene expression along ..
  20. Olfactory Circuits for Reproduction and Reward
    James A Cherry; Fiscal Year: 2013
    ..is differentially activated by male and female urinary volatiles in the two sexes and whether adult exposure to testosterone modulates the intensity of such responses...
  21. Kim Wallen; Fiscal Year: 2014
    ..Current hormonal therapies for FSDD use treatment with an estrogen and testosterone, but their effectiveness is limited...
  22. Sex-Hormones and the TMPRSS2: ERG Fusion in Prostate Cancer Progression
    Lorelei Mucci; Fiscal Year: 2013
    ..whether obesity, with its known regulation of the hormonal milieu causing higher levels of estrogen and reduced testosterone, is associated with PCa progression by interacting with the TMPRSS2:ERG fusion...
  23. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    ..in mouse impaired development of adult-type Leydig cells which resulted in a dramatic reduction of INSL3 and testosterone levels. Surprisingly, serum estradiol levels were significantly increased...
  24. Regulation of Rhox5 Transcriptional Elongation
    Marcy E Richardson; Fiscal Year: 2013
    ..subject of this proposal is the Rhox5 proximal promoter (Pp), which the Wilkinson laboratory showed depends on testosterone and androgen receptor (AR) for expression in Sertoli and caput epididymal cells...
  25. C Yan Cheng; Fiscal Year: 2016
    ..TNF?, and transforming growth factor-?2/-3, TGF-?2 or -?3) have a disruptive effect on BTB integrity, whereas testosterone promotes BTB function, illustrating that the opposing effects of these molecules are crucial to maintain the ..
  26. The influence of selenium on biomarkers of prostate cancer risk
    KARAM E EL-BAYOUMY; Fiscal Year: 2012
    ..biomarkers of risk PSA levels and testosterone metabolism, 3...
  27. LATRICE DOREEN FAULKNER; Fiscal Year: 2015
    ..We will then castrate IR/LepRPOMC males and administer exogenous testosterone to evaluate their sensitivity to negative feedback...
  28. CYNTHIA LOUISE BETHEA; Fiscal Year: 2014
    ..AR, and pivotal metabolic enzymes are localized in serotonin neurons and whether they are regulated by testosterone metabolites...
  29. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..characterized by subtype with pharmacological antagonists, and compared in brain slices of gonadectomized and testosterone-clamped, as well as of gonadal-intact, male prepubertal, pubertal, and adult GnRH-GFP transgenic mice...
  30. Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer Progression
    Hirak S Basu; Fiscal Year: 2012
    ..ROS levels are generally high in PCa cells as compared to their normal counterpart. Male hormone testosterone induces copious amounts of ROS generation specifically in PCa cells...
  31. Russ B Hauser; Fiscal Year: 2015
    ..and BMI;3) altered serum concentrations of hormones that regulate somatic growth and pubertal development (testosterone, inhibin- B, MIS, LH, FSH, IGF-1, IGF-BP3, TSH and free T4);4) altered adult testis function, specifically ..
  32. Kassim Traore; Fiscal Year: 2014
    ..litter size, and, later in life, Leydig cell hyperplasia, testicular atrophy, reduced serum levels of seru testosterone, and reduced fertility...
  33. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia M Kuhn; Fiscal Year: 2012
    ..In addition, we will determine if androgens like testosterone may exert the opposite effect to limit dopamine cell number, and so to limit cocaine-stimulated dopamine ..
  34. Delisa Fairweather; Fiscal Year: 2015
    ..sera than women, that sex differences exist in anti-inflammatory complement receptor (CR)1 expression with testosterone reducing CR1/2 during coxsackievirus B3 (CVB3) myocarditis resulting in increased Th1, C3, CD11b/CR3 ..
  35. ELIZABETH AUSTEN LAWSON; Fiscal Year: 2015
    ..AN is also associated with testosterone (T) deficiency, and preliminary data indicates that physiologic replacement leads to an increase in body mass ..
  36. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
    ..of our proposed studies in the next funding period are to: (i) understand how sex hormones (estrogen and testosterone) differentially regulate the expression of Ifi202, a candidate lupus susceptibility gene (encoding p202 protein)..
  37. Oxymax System with Teadmill for Quantifying Exercise in Mice
    Neil B Ruderman; Fiscal Year: 2012
    ..effects of exercise in mice with metabolic heart disease and myocardial dysfunction (Colucci)~ the ability of testosterone to enhance exercise performance in mice as they age (Bhasin and Jasuja)~ and the effects of overexpression and ..
  38. Adiposity and Outcomes of Clinically Localized Prostate Cancer
    Vincent L Freeman; Fiscal Year: 2013
    ..adipose tissue-derived cytokines, eicosanoids products of arachidonic acid, and metabolites of estrogen and testosterone. Lifestyle factors that associate with more rapid progression of clinically early-stage prostate cancer are of ..
  39. REINA C VILLAREAL; Fiscal Year: 2014
    ..Estrogen in males is mainly derived from the conversion of testosterone to estradiol by the enzyme aromatase...
  40. Participation in Cytochrome b5 in Anesthetic Metabolism
    Lucy A Waskell; Fiscal Year: 2010
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
  41. Testosterone Replacement Therapy in Advanced Chronic Kidney Disease
    Ralph Rabkin; Fiscal Year: 2009
    ..In 2/3 of males with advanced CKD, serum testosterone (TT) levels are reduced and likely contribute to the wasting...
  42. Ruth I Wood; Fiscal Year: 2016
    ..In 1991, testosterone was declared a controlled substance...
  43. Androgen Modulation of Neurodegeneration in Dopamine Neurons
    Rebecca L Cunningham; Fiscal Year: 2010
    ..aged males, gonadally intact aged males, and gonadectomized aged males plus replacement androgen (testosterone or dihydrotestosterone) for either a chronic (3 months) or acute (1 week) treatment time length prior to 6-OHDA ..
  44. ERIC DOUGLAS AUSTIN; Fiscal Year: 2014
    ..We hypothesize that estrogen-enhancing and testosterone-diminishing genotypes increase the risk of developing HPAH among BMPR2 mutation carriers...
  45. Regulation and Function of the Rhox5 Homeobox Gene
    MILES FROME WILKINSON; Fiscal Year: 2013
    ..Because it is testosterone regulated and required for the normal fertility of male mice, studying Rhox5 has the potential to illuminate ..
  46. Sathish Kumar; Fiscal Year: 2016
    ..As one of the common factors observed in these pregnancy pathologies, elevated maternal testosterone (T) is likely to contribute to the fetal programming of CV disorders...
  47. Wendy Saltzman; Fiscal Year: 2014
    ..energetic (resting and maximal metabolic rates, daily energy expenditure), hormonal (corticosterone, testosterone), and behavioral (ingestive behavior, activity levels) measures...
  48. Kathryn M Rexrode; Fiscal Year: 2016
    ..Specifically, we will test whether testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS), and sex hormone binding globulin (SHBG) might mediate ..
  49. Henryk F Urbanski; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): In men and male rhesus macaques testosterone (T) and dehydroepiandrosterone (DHEA, an adrenal androgen precursor) show characteristic 24-hour patterns in the circulation, and both show significant age-..
  50. Equol and Regulation of Prostate Growth
    Robert J Handa; Fiscal Year: 2011
    ..gland pathology is evidenced by current therapies for these diseases, which include reduction in circulating testosterone;inhibition of 5-alpha reductase, an enzyme that synthesizes the potent androgen, dihydrotestosterone;or ..
  51. Genes Influencing Social Behaviors
    DONALD WELLS PFAFF; Fiscal Year: 2010
    ..as part of reproduction), compared to an 'affiliative behavior', maternal care compared to testosterone-facilitated aggression...
  52. Interactions of MAO A with vulnerability factors for aggression
    Marco Bortolato; Fiscal Year: 2012
    ..serotonin (5-HT), norepinephrine (NE) and dopamine (DA);male gender, in relation to the high levels of androgen testosterone and its metabolites...
  53. JASON LEE SPERRY; Fiscal Year: 2014
    ..I hypothesize that estrogen will be associated with a protective effect while testosterone will be associated with poor outcome, as has been demonstrated repeatedly in the experimental animal literature...
  54. Maternal Androgen Excess: Vascular and Placental Function and Fetal Consequences
    KUNJU REDDIAR SATHISH KUMAR; Fiscal Year: 2012
    ..Based on our preliminary data that testosterone does not cross placenta and the observation of vascular and placental defects in pregnant rats with elevated T, ..
  55. Hormonal and Paracrine Regulation of Spermatogenesis
    Barry R Zirkin; Fiscal Year: 2010
    ..Naturally occurring ethnic differences in the response to testosterone (T)-based contraception will be studied to address this biological issue...
  56. MARA YVONNE ROTH; Fiscal Year: 2015
    ..The specific aims of this proposal are: 1) to define the minimum intratesticular testosterone concentration necessary for spermatogenesis in men;2) to identify if variation in intratesticular hormone ..
  57. Sukhbir S Mokha; Fiscal Year: 2014
    ..ORL1 agonists will be effective in adult men but their effectiveness may diminish in aging men as the levels of testosterone decline...
  58. Low birth weight, the kidney, and hypertension
    Barbara T Alexander; Fiscal Year: 2013
    ..Thus, we hypothesize that testosterone increases renal vascular resistance and exacerbates hypertension in male IUGR by enhancing the endothelin ..
  59. Structure and Function of Integral Membrane Enzyme Human Aromatase
    Debashis Ghosh; Fiscal Year: 2012
    ..determine the crystal structures of the complexes of P450arom with its (1) natural substrates androstenedione, testosterone, and 161-hydroxy-testosterone, as well as with (2) the inhibitors exemestane, letrozole, formestane, ..
  60. Matthew P Anderson; Fiscal Year: 2014
    ..In males this period is identified by a testosterone surge that declines rapidly soon after birth...
  61. Xin Li; Fiscal Year: 2014
    ..Hi-Myc mice will be treated with metformin, metformin plus rapamycin or vehicle for 12- and 24-weeks and MYC, testosterone (T), dihydrotestosterone (DHT), androgen receptor levels, proliferation, apoptosis indices and microvessel ..
  62. Sex/Gender Factors in Nicotine Addiction
    Nancy K Mello; Fiscal Year: 2012
    ..self-administration, and how acute and chronic treatment with neuroactive gonadal steroid hormones (estradiol, testosterone and progesterone) alters the reinforcing effects of nicotine...
  63. Wei Yan; Fiscal Year: 2014
    ..provided by applicant): Leydig cells are interstitial cells of the testis and represent the major source of testosterone (T) production in men...
  64. Sex Steroids, and TMJ Pain
    Larry Bellinger; Fiscal Year: 2009
    ..Our central hypothesis is that changes in physiological estrogen, progesterone and testosterone concentrations modulates acute pain as modeled in the TMJ through action at peripheral tissue(s) within and ..
  65. Cardiovascular and Prostatic Safety of Testosterone Therapy in Aging Males
    Stephen K Van Den Eeden; Fiscal Year: 2013
    ..libido, erectile dysfunction, fatigue and depression are found in conjunction with low levels of serum testosterone. Testosterone replacement therapy is a widespread and growing practice for treating androgen deficiency...
  66. Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOS
    Christopher R McCartney; Fiscal Year: 2012
    Project Summary/Abstract Polycystic ovary syndrome (PCOS) affects 6-8% of women and is marked by excess testosterone (T), irregular menses, and sub- or infertility...
  67. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    b>Testosterone, the predominant circulating androgen in men, also serves as a prohormone that is converted in the body to two active metabolites, estradiol 17beta and 5-alpha dihydrotestosterone (DHT)...
  68. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2005
    The role of testosterone as an anabolic agent is widely misunderstood and the mechanisms of its anabolic effects on the muscle are largely unknown...
  69. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    b>Testosterone supplementation increases muscle mass and decreases fat mass in healthy young men, hypogonadal men, and in HTV-infected men with weight loss; these observations have prompted clinical trials of testosterone supplementation in ..
  70. Testosterone:Physical Function in Men on Hemodialysis
    Shalender Bhasin; Fiscal Year: 2004
    ..b>Testosterone, when given in physiologic replacement doses, is an attractive anabolic intervention because it has been proven ..
  71. Prenatal Testosterone and Risk for Disordered Eating During Puberty
    KRISTEN CULBERT; Fiscal Year: 2009
    ..Research suggests that prenatal testosterone may masculinize (i.e...
  72. Pem Homeobox Gene Function During Spermatogenesis
    J Suzanne Lindsey; Fiscal Year: 2004
    ..Communication between Sertoli cells of the testis and germ cells is essential for spermatogenesis. Testosterone regulates spermatogenesis through binding Sertoli cell androgen receptors and resultant gene transcription...
  73. ANDROGENS REGULATE IGF PATHWAY AND PROSTATE DISEASES
    Julianne Imperato McGinley; Fiscal Year: 2001
    ..Androgens and IGFs interact to mutually potentiate their effects. Blocking conversion of testosterone to 5 alpha-dihydrotestosterone (DHT), inhibits prostatic IGF-I and IGF-I receptor gene expression while ..
  74. Allium Compounds in Control of Human Prostate Cancer
    JOHN PINTO; Fiscal Year: 2003
    ..in vitro, two events take place: (a) the proliferation rate of the LNCaP cells is markedly reduced and (b) testosterone concentration rapidly decreases in both the media in which the cells are growing as well as in the cells ..
  75. Nongenomic Androgen Signaling in Sertolli Cells
    William H Walker; Fiscal Year: 2010
    The long-term goal of this project remains to determine the molecular and cellular mechanisms by which testosterone regulates spermatogenesis...
  76. Testosterone Therapy After Hip Fracture in Elderly Women
    ELLEN BINDER; Fiscal Year: 2005
    ..The role of testosterone therapy for improving deficits in muscle mass, strength, and functional capacity in the frail elderly is ..
  77. REGULATION OF STEROIDOGENIC ENZYMES IN LEYDIG CELLS
    ANITA PAYNE; Fiscal Year: 1993
    ..of this project is to characterize the mechanisms that determine the capcity of Leydig cells to produce testosterone. We have approached this problem by studying the relationship of activities of steroid biosynthetic enzymes to ..
  78. MALE INFERTILITY AND ITS BIOLOGICAL BASIS
    Barry Zirkin; Fiscal Year: 2002
    ..Project I will examine the role of inadequate intratesticular testosterone concentration in human male infertility...
  79. METABOLISM & CONTROL OF TESTOSTERONE ANDROGENS IN MAN
    Richard Horton; Fiscal Year: 1990
    ..levels are reduced in androgen resistance and 5 alpha reductase deficiency cases in genetic males, and the testosterone/3 alpha diol glucuronide ratio is markedly altered...
  80. MOOD EFFECT OF TESTOSTERONE VS FLUOXETINE IN HIV ILLNESS
    Judith Rabkin; Fiscal Year: 2000
    ..In this competitive continuation application, the primary goal is to evaluate the antidepressant effects of testosterone compared to fluoxetine in a double-blind randomized placebo controlled clinical trial for HIV-positive patients ..
  81. REGULATION OF SPERMATOGENESIS IN MAMMALS
    Barry Zirkin; Fiscal Year: 1991
    We propose to examine the quantitative response of specific spermatogenic cells to defined changes in testosterone concentration within the seminiferous tubules of the adult rat. Two specific aims are proposed...