androstadienes

Summary

Summary: Derivatives of the steroid androstane having two double bonds at any site in any of the rings.

Top Publications

  1. ncbi Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
  2. pmc A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
    N Araki
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 135:1249-60. 1996
  3. pmc Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
    R A Fratti
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Cell Biol 154:631-44. 2001
  4. ncbi Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    Bartolome R Celli
    Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Am J Respir Crit Care Med 178:332-8. 2008
  5. pmc Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study
    Christine R Jenkins
    Woolcock Institute of Medical Research, Sydney, Australia
    Respir Res 10:59. 2009
  6. ncbi Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results
    C Crim
    GlaxoSmithKline, Research Triangle Park, NC 27709 3398, USA
    Eur Respir J 34:641-7. 2009
  7. ncbi Fluticasone furoate demonstrates efficacy in patients with asthma symptomatic on medium doses of inhaled corticosteroid therapy: an 8-week, randomised, placebo-controlled trial
    William W Busse
    Department of Medicine, University of Wisconsin, K4 910 CSC, 600 Highland Avenue, Madison, WI 53792, USA
    Thorax 67:35-41. 2012
  8. ncbi Reported pneumonia in patients with COPD: findings from the INSPIRE study
    Peter M A Calverley
    Clinical Science Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, England
    Chest 139:505-12. 2011
  9. ncbi Impact of preventing exacerbations on deterioration of health status in COPD
    S Spencer
    Dept of Health and Social Care, Brunel University, Isleworth, UK
    Eur Respir J 23:698-702. 2004
  10. pmc Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: the European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group
    Robert J Paridaens
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 26:4883-90. 2008

Research Grants

  1. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
  2. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
  3. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
  4. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
  5. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
  6. PHOSPHOINOSITIDE HYDROLYSIS AND BETA CELL SECRETION
    Walter Zawalich; Fiscal Year: 2006
  7. ASSESSMENT MODE AND VALIDITY OF SELF-REPORTS IN CHILDREN
    Bruce Bender; Fiscal Year: 2004
  8. CARE Network-UCSD Clinical Center
    Robert Zeiger; Fiscal Year: 2008
  9. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2008
  10. Adherence & Treatment Outcome in Adolescents in CAMPCS
    Bruce Bender; Fiscal Year: 2003

Detail Information

Publications275 found, 100 shown here

  1. ncbi Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
    ..Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown...
  2. pmc A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages
    N Araki
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 135:1249-60. 1996
    ..These findings indicate that PI 3-kinase is not necessary for receptor-mediated stimulation of pseudopod extension, but rather functions in the closure of macropinosomes and phagosomes into intracellular organelles...
  3. pmc Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
    R A Fratti
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Cell Biol 154:631-44. 2001
    ..tuberculosis. This study also identifies mycobacterial phosphoinositides as products with specialized toxic properties, interfering with discrete trafficking stages in phagosomal maturation...
  4. ncbi Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    Bartolome R Celli
    Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Am J Respir Crit Care Med 178:332-8. 2008
    ..Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in lung function. No drug has been shown conclusively to reduce this decline...
  5. pmc Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study
    Christine R Jenkins
    Woolcock Institute of Medical Research, Sydney, Australia
    Respir Res 10:59. 2009
    ..However, there are only limited data about the influence of GOLD severity staging on the effectiveness of SFC, particularly in patients with milder disease...
  6. ncbi Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study results
    C Crim
    GlaxoSmithKline, Research Triangle Park, NC 27709 3398, USA
    Eur Respir J 34:641-7. 2009
    ..Despite the benefits of ICS-containing regimens in COPD management, healthcare providers should remain vigilant regarding the possible development of pneumonia as a complication in COPD patients receiving such therapies...
  7. ncbi Fluticasone furoate demonstrates efficacy in patients with asthma symptomatic on medium doses of inhaled corticosteroid therapy: an 8-week, randomised, placebo-controlled trial
    William W Busse
    Department of Medicine, University of Wisconsin, K4 910 CSC, 600 Highland Avenue, Madison, WI 53792, USA
    Thorax 67:35-41. 2012
    ..FF is being developed as a once-daily treatment in combination with the long-acting β(2) agonist vilanterol trifenatate for asthma and chronic obstructive pulmonary disease...
  8. ncbi Reported pneumonia in patients with COPD: findings from the INSPIRE study
    Peter M A Calverley
    Clinical Science Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, England
    Chest 139:505-12. 2011
    ..We investigated patient characteristics and symptoms occurring before pneumonia reports in the Investigating New Standards for Prophylaxis in Reduction of Exacerbations (INSPIRE) study...
  9. ncbi Impact of preventing exacerbations on deterioration of health status in COPD
    S Spencer
    Dept of Health and Social Care, Brunel University, Isleworth, UK
    Eur Respir J 23:698-702. 2004
    ..Statistical modelling showed the beneficial effect of fluticasone propionate on deterioration in health status to be largely due to its effect on exacerbation frequency...
  10. pmc Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: the European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group
    Robert J Paridaens
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 26:4883-90. 2008
    ....
  11. pmc Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer
    I Judson
    Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT, UK
    Br J Cancer 90:2317-25. 2004
    ..Adrenocortical suppression may necessitate concomitant administration of replacement glucocorticoid...
  12. ncbi The relationship between lumenal and limiting membranes in swollen late endocytic compartments formed after wortmannin treatment or sucrose accumulation
    N A Bright
    Department of Clinical Biochemistry and Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, UK
    Traffic 2:631-42. 2001
    ....
  13. ncbi Budesonide/formoterol vs. salmeterol/fluticasone in COPD: a systematic review and adjusted indirect comparison of pneumonia in randomised controlled trials
    D M G Halpin
    Department of Respiratory Medicine, Royal Devon and Exeter Hospital, Exeter, UK
    Int J Clin Pract 65:764-74. 2011
    ....
  14. ncbi Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
    J N Sarkaria
    Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 58:4375-82. 1998
    ..These results identify wortmannin as an inhibitor of ATM activity and suggest that ATM and DNA-PK are relevant targets for the radiosensitizing effect of this drug in cancer cells...
  15. ncbi The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study
    Keith L Hattotuwa
    Lung Pathology Unit, Imperial College School of Medicine at the Royal Brompton Hospital, London, United Kingdom
    Am J Respir Crit Care Med 165:1592-6. 2002
    ..The data indicate that inhaled fluticasone does affect selected aspects of airway inflammation in COPD, and this may explain, in part, the decrease in exacerbations seen in long-term studies with fluticasone propionate...
  16. ncbi Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT
    Stephen Chia
    Division of Medical Oncology, British Columbia Cancer Agency, University of British Columbia, 600 West 10 Avenue, Vancouver, BC, Canada
    J Clin Oncol 26:1664-70. 2008
    ..Because many patients subsequently experience progression or relapse, it is important to identify agents with efficacy after AI failure...
  17. ncbi Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial
    Cornelis J H Van De Velde
    Leiden University Medical Centre, Leiden, Netherlands
    Lancet 377:321-31. 2011
    ..We therefore compared the long-term effects of exemestane monotherapy with sequential treatment (tamoxifen followed by exemestane)...
  18. ncbi EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
    A Simonsen
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Oslo
    Nature 394:494-8. 1998
    ....
  19. ncbi Effect of fluticasone propionate/salmeterol (250/50) on COPD exacerbations and impact on patient outcomes
    Antonio Anzueto
    University of Texas Health Science Center at San Antonio, San Antonio, TX, 78230, USA
    COPD 6:320-9. 2009
    ..2%). FSC 250/50 is more effective than SAL at reducing the rate of moderate/severe exacerbations. These data confirm the beneficial effect of FSC on the management of COPD exacerbations and support the use of FSC in patients with COPD...
  20. ncbi Effect of fluticasone propionate/salmeterol (250/50 microg) or salmeterol (50 microg) on COPD exacerbations
    Gary T Ferguson
    Pulmonary Research Institute of SouthEast Michigan, 28807 Eight Mile Road, Suite 103, Livonia, MI 48152, USA
    Respir Med 102:1099-108. 2008
    ..This randomized, double-blind, parallel-group, multicenter study evaluated the effect of fluticasone propionate/salmeterol 250/50 and salmeterol 50 microg twice daily on moderate to severe exacerbations...
  21. ncbi Smelling a single component of male sweat alters levels of cortisol in women
    Claire Wyart
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA
    J Neurosci 27:1261-5. 2007
    ..Critically, this study identified a single component of sweat, androstadienone, as capable of exerting such influence. This result points to a potential role for synthetic human chemosignals in clinical applications...
  22. ncbi Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD)...
  23. pmc Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial
    Jean Bourbeau
    Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Centre, Montreal, Quebec, Canada
    Thorax 62:938-43. 2007
    ..A study was therefore undertaken to evaluate combined salmeterol/fluticasone propionate (SFC) and fluticasone propionate (FP) alone on inflammatory cells in the airways of patients with COPD...
  24. ncbi Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial
    Peter Calverley
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Lancet 361:449-56. 2003
    ..We postulated that a combination of these treatments would be better than each component used alone...
  25. ncbi A randomized, placebo-controlled trial (NCIC CTG MAP.2) examining the effects of exemestane on mammographic breast density, bone density, markers of bone metabolism and serum lipid levels in postmenopausal women
    T Cigler
    Weill Cornell Medical College, New York, NY, USA
    Breast Cancer Res Treat 126:453-61. 2011
    ..Changes in lipid parameters on this trial were modest and reversible...
  26. ncbi Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease
    Neil C Barnes
    Department of Respiratory Medicine, London Chest Hospital, London, UK
    Am J Respir Crit Care Med 173:736-43. 2006
    ..No currently available treatment is reported to reduce the exaggerated airway wall inflammation of chronic obstructive pulmonary disease...
  27. ncbi Fulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): a composite, multicentr
    Stephen Rd Johnston
    Royal Marsden NHS Foundation Trust, London, UK
    Lancet Oncol 14:989-98. 2013
    ..The aim of the SoFEA trial was to assess a maximum double endocrine targeting approach with the steroidal anti-oestrogen fulvestrant in combination with continued oestrogen deprivation...
  28. pmc Estrogen receptor and progesterone receptor as predictive biomarkers of response to endocrine therapy: a prospectively powered pathology study in the Tamoxifen and Exemestane Adjuvant Multinational trial
    John M S Bartlett
    Endocrine Cancer Group, Edinburgh Cancer Research Centre, Western General Hospital, Crewe Rd South, Edinburgh, EH4 2XR, United Kingdom
    J Clin Oncol 29:1531-8. 2011
    ....
  29. pmc Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella pneumoniae in mice
    Craig M Patterson
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Respir Res 13:40. 2012
    ..There is limited work describing FP effects on host defenses against bacterial pneumonia...
  30. pmc Brain response to putative pheromones in homosexual men
    Ivanka Savic
    Department of Clinical Neuroscience, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 102:7356-61. 2005
    ..These findings show that our brain reacts differently to the two putative pheromones compared with common odors, and suggest a link between sexual orientation and hypothalamic neuronal processes...
  31. ncbi Inhaled corticosteroids or long-acting beta-agonists alone or in fixed-dose combinations in asthma treatment: a systematic review of fluticasone/budesonide and formoterol/salmeterol
    Christian Frois
    Analysis Group, Boston, Massachusetts 02199 7636, USA
    Clin Ther 31:2779-803. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting inhaled beta(2)-agonists (LABAs) are recommended treatment options for asthma...
  32. pmc Activation of Akt by the bacterial inositol phosphatase, SopB, is wortmannin insensitive
    Kendal G Cooper
    Laboratory of Intracellular Parasites, National Institutes of Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of America
    PLoS ONE 6:e22260. 2011
    ..Altogether these data demonstrate that Salmonella activates Akt via a wortmannin insensitive mechanism that is likely a class I PI3K-independent process that incorporates some essential elements of the canonical pathway...
  33. pmc Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition
    C Rossios
    Airway Disease Section, NHLI, Imperial College, London, UK
    Br J Pharmacol 167:775-86. 2012
    ..Here we show that the long-acting β(2) -agonist formoterol (FM) reversed corticosteroid insensitivity under oxidative stress via inhibition of phosphoinositide-3-kinase (PI3K) signalling...
  34. pmc Rice SCAMP1 defines clathrin-coated, trans-golgi-located tubular-vesicular structures as an early endosome in tobacco BY-2 cells
    Sheung Kwan Lam
    Department of Biology and Molecular Biotechnology Program, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Plant Cell 19:296-319. 2007
    ..These early endosomal compartments resemble the previously described partially coated reticulum and trans-Golgi network in plant cells...
  35. pmc The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer
    C J Fabian
    Breast Cancer Prevention Center, Division of Clinical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7418, USA
    Int J Clin Pract 61:2051-63. 2007
    ..an AI for risk reduction and (ii) recognise and manage AI-associated adverse events. The primary purpose of this review is to help internists with these two tasks...
  36. pmc Early onset of effect of salmeterol and fluticasone propionate in chronic obstructive pulmonary disease
    J Vestbo
    North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, UK
    Thorax 60:301-4. 2005
    ..Combined treatment with inhaled corticosteroids and long acting beta2 agonists is approved for the treatment of chronic obstructive pulmonary disease (COPD), but little is known about the onset of effect of the combination...
  37. pmc The bioavailability and airway clearance of the steroid component of budesonide/formoterol and salmeterol/fluticasone after inhaled administration in patients with COPD and healthy subjects: a randomized controlled trial
    Chris Dalby
    Respiratory Medicine Unit, City Hospital Campus, Nottingham University, Nottingham, UK
    Respir Res 10:104. 2009
    ....
  38. pmc Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis
    S Holt
    Wellington Asthma Research Group, Wellington School of Medicine, PO Box 7343, Wellington, New Zealand
    BMJ 323:253-6. 2001
    ..However, these findings were limited by the lack of data on individual patients and by the paucity of dose-response studies that included doses of >500 microg/day...
  39. pmc Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus long-acting beta(2)-agonists for chronic obstructive pulmonary disease
    Luis Javier Nannini
    Pulmonary Section, Hospital E Peron, G Baigorria, Argentina
    Cochrane Database Syst Rev 9:CD006829. 2012
    ..This updated review compared compound LABA plus ICS therapy (LABA/ICS) with the LABA component drug given alone...
  40. ncbi Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C
    H Tong
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Circ Res 87:309-15. 2000
    ..PC induced phosphorylation of protein kinase B and translocation of PKC epsilon, and it increased NO production, and these effects were blocked by WM, which suggests a role for PI3-kinase in PC upstream of PKC and NO...
  41. ncbi Significant variability in response to inhaled corticosteroids for persistent asthma
    Stanley J Szefler
    National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
    J Allergy Clin Immunol 109:410-8. 2002
    ..A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy...
  42. ncbi Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
    Lydia Lacerda
    Hatter Cardiovascular Research Institute, Cardioprotection Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Cardiovasc Res 84:201-8. 2009
    ....
  43. pmc Comparative efficacy of indacaterol 150 μg and 300 μg versus fixed-dose combinations of formoterol + budesonide or salmeterol + fluticasone for the treatment of chronic obstructive pulmonary disease--a network meta-analysis
    Shannon Cope
    Mapi Values, Boston, MA, USA
    Int J Chron Obstruct Pulmon Dis 6:329-44. 2011
    ....
  44. pmc Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer
    Tadas Vasaitis
    Health Sciences Facility, University of Maryland, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Mol Cancer Ther 7:2348-57. 2008
    ..VN/124-1 is more efficacious than castration in the LAPC4 xenograft model, suggesting that the compound has potential for the treatment of prostate cancer...
  45. ncbi AtSNX1 defines an endosome for auxin-carrier trafficking in Arabidopsis
    Yvon Jaillais
    Reproduction et Developpement des Plantes, IFR128 Biosciences Lyon Gerland, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Universite Claude Bernard Lyon I, Ecole Normale Superieure de Lyon, Lyon, France
    Nature 443:106-9. 2006
    ..Our data reveal the existence of a novel endosomal compartment involved in PIN2 endocytic sorting and plant development...
  46. pmc Brain response to putative pheromones in lesbian women
    Hans Berglund
    Department of Medicine, and Stockholm Brain Institute, Karolinska University Hospital, Karolinska Institutet, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 103:8269-74. 2006
    ..These data support our previous results about differentiated processing of pheromone-like stimuli in humans and further strengthen the notion of a coupling between hypothalamic neuronal circuits and sexual preferences...
  47. pmc Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based int
    Matthew J Ellis
    Siteman Cancer Center, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Clin Oncol 29:2342-9. 2011
    ..To study this treatment option, responses to three AIs were compared in a randomized phase II neoadjuvant trial designed to select agents for phase III investigations...
  48. ncbi Evidence that androstadienone, a putative human chemosignal, modulates women's attributions of men's attractiveness
    Tamsin K Saxton
    School of Biological Sciences, University of Liverpool, Liverpool, L69 7ZB, UK
    Horm Behav 54:597-601. 2008
    ..The results suggest that androstadienone can influence women's attraction to men, and also that research into the modulatory effects of androstadienone should be made within ecologically valid contexts...
  49. ncbi Effects of loteprednol/tobramycin versus dexamethasone/tobramycin on intraocular pressure in healthy volunteers
    Edward J Holland
    Cincinnati Eye Institute and University of Cincinnati, Cincinnati, OH, USA
    Cornea 27:50-5. 2008
    ..To compare the steroid-induced intraocular pressure (IOP) and other ocular adverse effects of loteprednol etabonate 0.5% and tobramycin 0.3% ophthalmic suspension with those of dexamethasone 0.1% and tobramycin 0.3% ophthalmic suspension...
  50. ncbi X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain
    Keith Biggadike
    J Med Chem 51:3349-52. 2008
    ....
  51. ncbi Randomized comparison of strategies for reducing treatment in mild persistent asthma
    Stephen P Peters
    Wake Forest University, Winston Salem, NC, USA
    N Engl J Med 356:2027-39. 2007
    ....
  52. ncbi Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein
    Narasimman Gurusamy
    Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, 06030 1110, USA
    J Cell Mol Med 13:373-87. 2009
    ..These results clearly indicate that myocardial protection elicited by adaptation is mediated at least in part via up-regulation of autophagy in association with BAG-1 protein...
  53. pmc Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial
    E F M Wouters
    Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
    Thorax 60:480-7. 2005
    ..Combined treatment with ICS and long acting beta2 agonists (LABA) may provide benefit to the stability of COPD, but it is unknown if withdrawal of ICS will result in disease deterioration...
  54. pmc Effects of fluticasone propionate on inflammatory cells in COPD: an ultrastructural examination of endobronchial biopsy tissue
    M J Gizycki
    Lung Pathology Unit, Imperial College School of Medicine at the Royal Brompton Hospital, London, UK London Chest Hospital, London, UK
    Thorax 57:799-803. 2002
    ..Inhaled corticosteroids (ICS) markedly reduce bronchial mucosal inflammation in asthma but whether they have an anti-inflammatory effect in airway tissue in chronic obstructive pulmonary disease (COPD) is unknown...
  55. pmc Uptake of a fluorescent marker in plant cells is sensitive to brefeldin A and wortmannin
    Neil Emans
    Institute for Molecular Biotechnology, Biology VII, Rheinisch Westfälische Technische Hochschule Aachen, Worringerweg 1, D 52074 Aachen, Germany
    Plant Cell 14:71-86. 2002
    ..Three-dimensional time lapse imaging revealed that FM1-43-labeled vacuoles and vesicles are highly dynamic. Thus, FM1-43 serves as a fluorescent marker for imaging and quantifying membrane endocytosis in intact plant cells...
  56. ncbi The efficacy and safety of fluticasone propionate (250 microg)/salmeterol (50 microg) combined in the Diskus inhaler for the treatment of COPD
    Nicola A Hanania
    Baylor College of Medicine, Pulmonary Critical Care, Ben Taub General Hospital, 1504 Taub Loop, Houston, TX 77030, USA
    Chest 124:834-43. 2003
    ....
  57. pmc Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke
    Ruth E MacRedmond
    Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Respir Res 8:84. 2007
    ..Modulation of TLR4 in respiratory epithelium may have important implications for airway inflammation and infection in response to inhaled pathogens...
  58. ncbi Regulation of translation initiation by FRAP/mTOR
    A C Gingras
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Genes Dev 15:807-26. 2001
  59. ncbi Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease
    Donald A Mahler
    Dartmouth Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
    Am J Respir Crit Care Med 166:1084-91. 2002
    ..We conclude that FSC improved lung function and reduced the severity of dyspnea compared with individual components and placebo...
  60. ncbi Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners
    Peter Varnai
    Endocrinology and Reproduction Research Branch, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 118:4879-88. 2005
    ....
  61. ncbi Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
    G Rena
    Department of Biochemistry, Medical Research Council Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 274:17179-83. 1999
    ..The conservation of Thr-24, Ser-256, and Ser-319 and the sequences surrounding them in DAF16 therefore suggests that DAF16 is also a direct substrate for PKB in C. elegans...
  62. ncbi The efficacy and safety of combination salmeterol (50 microg)/fluticasone propionate (500 microg) inhalation twice daily via accuhaler in Chinese patients with COPD
    Jin ping Zheng
    Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, People s Republic of China
    Chest 132:1756-63. 2007
    ....
  63. ncbi Synthesis and function of 3-phosphorylated inositol lipids
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, Riding House Street, London W1W 7BS
    Annu Rev Biochem 70:535-602. 2001
    ..This field is now moving toward a genetic dissection of 3-phosphoinositide action in a variety of model organisms. Such approaches will reveal the true role of the 3-phosphoinositides at the organismal level in health and disease...
  64. ncbi Inhaled corticosteroids versus long-acting beta(2)-agonists for chronic obstructive pulmonary disease
    Sally Spencer
    Faculty of Health and Medicine, Lancaster University, Bailrigg, Lancaster, Lancashire, UK, LA1 4YD
    Cochrane Database Syst Rev 12:CD007033. 2011
    ..These interventions are often taken together in a combination inhaler. However, the relative added value of the two individual components is unclear...
  65. ncbi Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial
    Shawn D Aaron
    The Ottawa Health Research Institute and University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 146:545-55. 2007
    ..Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations of inhaled corticosteroids, long-acting beta-agonists, and long-acting anticholinergic bronchodilators is common but unstudied...
  66. pmc A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment
    Katrina Steiling
    Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Respir Crit Care Med 187:933-42. 2013
    ..Molecular phenotyping of chronic obstructive pulmonary disease (COPD) has been impeded in part by the difficulty in obtaining lung tissue samples from individuals with impaired lung function...
  67. pmc Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma
    G W Chalmers
    Departments of Respiratory Medicine and Immunology, Western Infirmary, Glasgow G11 6NT, UK
    Thorax 57:226-30. 2002
    ..A study was undertaken to investigate the effect of active cigarette smoking on responses to treatment with inhaled corticosteroids in patients with mild asthma...
  68. ncbi PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents
    Hailin Zhang
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Neuron 37:963-75. 2003
    ..Finally, native or recombinant channels inhibited by muscarinic agonists can be activated by PIP(2). Our data strongly suggest that PIP(2) acts as a membrane-diffusible second messenger to regulate directly the activity of KCNQ currents...
  69. ncbi Bronchodilator effect of an inhaled combination therapy with salmeterol + fluticasone and formoterol + budesonide in patients with COPD
    M Cazzola
    Department of Respiratory Medicine, A Cardarelli Hospital, Unit of Pneumology and Allergology, Naples, Italy
    Respir Med 97:453-7. 2003
    ..The results indicate that an inhaled combination therapy with a long-acting beta2-agonist and an inhaled corticosteroid appears to be effective in improving airway limitation after acute administration in patients suffering from COPD...
  70. ncbi Long-term treatment with fluticasone propionate/salmeterol via Diskus improves asthma control versus fluticasone propionate alone
    Rohit K Katial
    National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 32:127-36. 2011
    ..In addition, FSC 250/50 micrograms-treated subjects experienced fewer severe asthma exacerbations than subjects treated with FP 250 micrograms...
  71. pmc Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways
    David S Gelinas
    Department of Pharmacology, University of Montreal, Montreal QC, Canada
    Br J Pharmacol 137:1021-30. 2002
    ..5. In conclusion, VEGF induces an immediate cGMP synthesis through the PLC-Ca2+/CaM pathway, and that the induction of delayed cGMP synthesis implies Akt and PKC activity...
  72. pmc Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity
    Adam C Resnick
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:12783-8. 2005
    ..In yeast, this inositol lipid kinase activity physiologically regulates transcription...
  73. ncbi Promising results with exemestane in the first-line treatment of metastatic breast cancer: a randomized phase II EORTC trial with a tamoxifen control
    R Paridaens
    Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium
    Clin Breast Cancer 1:S19-21. 2000
    ..Based on these encouraging results, a phase III trial will compare EXE and TAM...
  74. ncbi The putative pheromone androstadienone activates cortical fields in the human brain related to social cognition
    Balazs Gulyas
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Neurochem Int 44:595-600. 2004
    ..These brain regions can be identified as cortical fields underlying other than olfactory functions, including various aspects of social cognition and attention...
  75. ncbi Step-down compared to fixed-dose treatment with inhaled fluticasone propionate in asthma
    Antonio Foresi
    Respiratory Pathophysiology Unit, Sesto San Giovanni Hospital, Sesto San Giovanni, Italy
    Chest 127:117-24. 2005
    ..Although the most appropriate strategy for the stepping down has not yet been defined, quantification of sputum eosinophils and bronchial hyperresponsiveness (BHR) are indeed measures of asthma control...
  76. ncbi Aromatase inhibitors: past, present and future in breast cancer therapy
    Udayan Dutta
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Med Oncol 25:113-24. 2008
    ..A comprehensive discussion of the past, present, and future of aromatase inhibitors is conducted in this review...
  77. ncbi Add-on salmeterol compared to double dose fluticasone in pediatric asthma: a double-blind, randomized trial (VIAPAED)
    Monika Gappa
    Hannover Medical School, Hannover, Germany
    Pediatr Pulmonol 44:1132-42. 2009
    ....
  78. pmc Localization of green fluorescent protein fusions with the seven Arabidopsis vacuolar sorting receptors to prevacuolar compartments in tobacco BY-2 cells
    Yansong Miao
    Department of Biology and Molecular Biotechnology Program, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    Plant Physiol 142:945-62. 2006
    ..Therefore, the seven AtVSRs are localized to MVBs in tobacco BY-2 cells, and wortmannin-induced vacuolation of PVCs is a general response in plants...
  79. ncbi Fluticasone and budesonide inhibit cytokine release in human lung epithelial cells and alveolar macrophages
    A Ek
    Department of Occupational Medicine, National Institute for Working Life, Solna, Sweden
    Allergy 54:691-9. 1999
    ..In vitro, the onset of this effect was rapid...
  80. ncbi IL-1beta-induced phosphorylation of PKB/Akt depends on the presence of IRAK-1
    Detlef Neumann
    Hannover Medical School, Department of Pharmacology, Hannover, Germany
    Eur J Immunol 32:3689-98. 2002
    ..Possible models of the interaction between IRAK-1 and the PI3-K pathway are discussed...
  81. ncbi Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: a phase II trial
    P E Lønning
    Department of Oncology, Haukeland University Hospital, Bergen, Norway
    J Clin Oncol 18:2234-44. 2000
    ....
  82. ncbi Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    Hui Chen
    Diabetes Unit, Laboratory of Clinical Investigation, NCCAM, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:45021-6. 2003
    ..Thus, the effects of adiponectin to augment metabolic actions of insulin in vivo may be due, in part, to vasodilator actions of adiponectin...
  83. pmc Can inhaled fluticasone alone or in combination with salmeterol reduce systemic inflammation in chronic obstructive pulmonary disease? Study protocol for a randomized controlled trial [NCT00120978]
    Don D Sin
    Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada
    BMC Pulm Med 6:3. 2006
    ....
  84. ncbi Deterioration in asthma control when subjects receiving fluticasone propionate/salmeterol 100/50 mcg Diskus are "stepped-down"
    Steven M Koenig
    University of Virginia, Division of Pulmonary Medicine and Critical Care, Charlottesville, VA 22908, USA
    J Asthma 45:681-7. 2008
    ..This study provides support that treatment of both inflammation and smooth muscle dysfunction may be necessary to achieve and maintain asthma control in patients uncontrolled on ICS...
  85. pmc Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response
    Charles J Ryan
    Genitourinary Medical Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94115, USA
    Clin Cancer Res 17:4854-61. 2011
    ....
  86. ncbi Healthcare costs associated with initial maintenance therapy with fluticasone propionate 250 μg/salmeterol 50 μg combination versus anticholinergic bronchodilators in elderly US Medicare-eligible beneficiaries with COPD
    Anand A Dalal
    GlaxoSmithKline, Research Triangle Park, NC, USA
    J Med Econ 12:339-47. 2009
    ....
  87. ncbi Adherence to inhaled therapy, mortality and hospital admission in COPD
    J Vestbo
    Respiratory Medicine Research Group, University of Manchester, Manchester, UK
    Thorax 64:939-43. 2009
    ..Little is known about adherence to inhaled medication in chronic obstructive pulmonary disease (COPD) and the impact on mortality and morbidity...
  88. ncbi Economic assessment of initial maintenance therapy for chronic obstructive pulmonary disease
    Manabu Akazawa
    Department of Health Policy and Administration, University of North Carolina at Chapel Hill, USA
    Am J Manag Care 14:438-48. 2008
    ....
  89. ncbi Healthcare use and costs in patients with chronic bronchitis initiating maintenance therapy with fluticasone/salmeterol vs other inhaled maintenance therapies
    Thomas E Delea
    Policy Analysis Inc PAI, Brookline, MA, USA
    Curr Med Res Opin 25:1-13. 2009
    ....
  90. pmc Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11
    B Sönnichsen
    Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    J Cell Biol 149:901-14. 2000
    ..We propose that endosomes are organized as a mosaic of different Rab domains created through the recruitment of specific effector proteins, which cooperatively act to generate a restricted environment on the membrane...
  91. ncbi Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone : a cross-over study in healthy volunteers
    Chet L Leach
    3M Pharmaceuticals, St Paul, MN, USA
    Chest 122:510-6. 2002
    ..To compare the lung deposition of radiolabeled hydrofluoroalkane-134a beclomethasone dipropionate (HFA-BDP) with chlorofluorocarbon fluticasone propionate (CFC-FP) and chlorofluorocarbon beclomethasone (CFC-BDP)...
  92. ncbi Putative human pheromone androstadienone attunes the mind specifically to emotional information
    Tom A Hummer
    Committee on Computational Neuroscience, University of Chicago, Chicago, IL 60637, USA
    Horm Behav 55:548-59. 2009
    ..Taken together, these findings demonstrate that subliminal androstadienone guides psychological resources to specifically engage stimuli with emotional significance and does not alter attention to social or general cognitive information...
  93. ncbi Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements
    Michael R Edwards
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London, London W2 1PG, United Kingdom
    J Biol Chem 282:15366-75. 2007
    ....
  94. ncbi Prevention of death in COPD
    Carlo La Vecchia
    N Engl J Med 356:2211-2; author reply 2213-4. 2007
  95. ncbi Maintaining asthma control in persistent asthma: comparison of three strategies in a 6-month double-blind randomised study
    Philippe Godard
    Hopital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
    Respir Med 102:1124-31. 2008
    ..There was no difference between SFC100 and SFC250. The mean annual rate of moderate exacerbations was 0.16 in both SFC 250 and SFC 100 groups, and 0.21 in FP 250 group (ns, Poisson analysis). All treatments were well tolerated...
  96. ncbi Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    L del Peso
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Science 278:687-9. 1997
    ..Thus, the proapoptotic function of BAD is regulated by the PI 3-kinase-Akt pathway...
  97. ncbi Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics and Respiratory Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland
    Arch Intern Med 159:941-55. 1999
    ..To appraise the data on systemic adverse effects of inhaled corticosteroids...
  98. ncbi The effect of exemestane, anastrozole, and tamoxifen on lipid profiles in Japanese postmenopausal early breast cancer patients: final results of National Surgical Adjuvant Study BC 04, the TEAM Japan sub-study
    Y Hozumi
    Department of Breast and General Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Ann Oncol 22:1777-82. 2011
    ....
  99. pmc Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
    Xiu Fen Ming
    Vascular Biology, Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Mol Cell Biol 22:8467-77. 2002
    ..Taken together, these data demonstrate that Rho/ROCK pathway negatively regulates eNOS phosphorylation through inhibition of PKB, whereas it downregulates eNOS expression independent of PKB...
  100. ncbi Preferences of adult patients with allergic rhinitis for the sensory attributes of fluticasone furoate versus fluticasone propionate nasal sprays: a randomized, multicenter, double-blind, single-dose, crossover study
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center, San Diego, California, USA
    Clin Ther 30:271-9. 2008
    ..Product attributes influence patient preference for intranasal corticosteroid therapy in allergic rhinitis (AR)...
  101. ncbi Addition of salmeterol to low-dose fluticasone versus higher-dose fluticasone: an analysis of asthma exacerbations
    J Matz
    Atlantic Asthma and Allergy Center, Inc, Baltimore, MD, USA
    J Allergy Clin Immunol 107:783-9. 2001
    ..The ability to detect deteriorating asthma and the severity of exacerbation was similar between groups...

Research Grants71

  1. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
    ..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
  2. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
  3. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  4. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  5. RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND SINUSITIS
    Fuad Baroody; Fiscal Year: 2003
    ..This will hopefully help to improve our therapeutic modalities for this enigmatic illness that affects millions of Americans every year. ..
  6. PHOSPHOINOSITIDE HYDROLYSIS AND BETA CELL SECRETION
    Walter Zawalich; Fiscal Year: 2006
    ..These aims will be accomplished by using sound principles of experimentation and employing isolated islets that retain their in vivo sensitivity to glucose. ..
  7. ASSESSMENT MODE AND VALIDITY OF SELF-REPORTS IN CHILDREN
    Bruce Bender; Fiscal Year: 2004
    ..Results from this investigation are expected to have immediate and direct implication for clinical research in asthma and with other chronic conditions. ..
  8. CARE Network-UCSD Clinical Center
    Robert Zeiger; Fiscal Year: 2008
    ..abstract_text> ..
  9. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2008
    ..abstract_text> ..
  10. Adherence & Treatment Outcome in Adolescents in CAMPCS
    Bruce Bender; Fiscal Year: 2003
    ..abstract_text> ..
  11. Childhood Asthma Research and Education Network: Denver Site
    Stanley Szefler; Fiscal Year: 2008
    ..End of abstract.) [unreadable] [unreadable]..
  12. ESTROGEN BIOTRANSFORMATIONS AND BREAST CANCER ETIOLOGY
    ROBERT BRUEGGEMEIER; Fiscal Year: 2006
    ..3) To measure cellular levels of aromatase expression and cyclooxygenases expression in human breast cancer specimens. ..
  13. A proteomics approach in the study of novel COPD markers
    Ratko Djukanovic; Fiscal Year: 2005
    ..Finally, applying the antibodies to archival lung tissue samples we will be able to localize the COPD-selective proteins to the airway and alveoli, adding valuable knowledge to our understanding of COPD mechanisms. ..
  14. Phosphoinositide 3-Kinase Function in Lymphocytes
    David Fruman; Fiscal Year: 2006
    ..Biochemical assays will be used to analyze signaling in purified T cells. These studies will increase our understanding of PI3K signaling, a central control point in lymphocyte proliferation. ..
  15. Mitochondrial KATP Channel in Cardioprotection
    Muhammad Ashraf; Fiscal Year: 2006
    ..abstract_text> ..
  16. FlaxSeed Lignan for Breast Cancer Chemoprevention
    CAROL FABIAN; Fiscal Year: 2007
    ..If positive, the results of this study will be critical to the design and implementation of a placebo-controlled Phase II prevention trial with Brevail and/or commercial flaxseed. [unreadable] [unreadable]..
  17. Mechanisms of Leptin Signaling in the Hypothalamus
    Abhiram Sahu; Fiscal Year: 2007
    ..These studies will further our understanding of leptin signaling in the hypothalamus in relation to feeding, and therefore will be relevant to the development of therapeutic approaches to eating disorders. [unreadable] [unreadable]..
  18. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2007
    ....
  19. Ad-vectors and Granulosa Cell Signaling
    Anthony Zeleznik; Fiscal Year: 2007
    ..In addition, results may provide new information regarding signaling pathways that may be affected in PCOS. ..
  20. Breast Cancer Prevention by Letrozole in High Risk Women
    Carol J Fabian; Fiscal Year: 2010
    ....
  21. Individualized Interventions to Improve Asthma Adherence
    Andrea Apter; Fiscal Year: 2009
    ..We will estimate the incremental cost-effectiveness of PS. ..
  22. MOUSE MODELS OF INSULIN RESISTANCE
    Domenico Accili; Fiscal Year: 2009
    ..abstract_text> ..
  23. NUTRIENT EFFECTS ON INSULIN ACTION
    Michael Pagliassotti; Fiscal Year: 2009
    ..abstract_text> ..
  24. Effect of Drugs on Myocardial Hypoxia
    Garrett Gross; Fiscal Year: 2009
    ..Information gained from these studies will hopefully lead to new therapies to treat patients with ischemic heart disease. ..
  25. ANDROGEN SYNTHESIS INHIBITORS FOR PROSTATE CANCER
    Angela Brodie; Fiscal Year: 2008
    ..Determine effective doses, scheduling, and route of administration and b. Compare the effect of lead inhibitors and castration on apoptosis to identify the best compound. ..
  26. The Effect of Mycoplasma on Chronic Asthma
    Richard Martin; Fiscal Year: 2008
    ..pneumoniae and asthma will be obtained through this PPG and will ultimately give new knowledge to the understanding of asthma pathophysiology and potential future novel therapies. ..
  27. University of Texas SPORE in Prostate Cancer
    Christopher Logothetis; Fiscal Year: 2007
    ..The achievement of the aims of this Prostate Cancer SPORE proposal will contribute to the development of effective treatments for patients with prostate cancer. ..
  28. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2005
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  29. Plasma Membrane Trafficking in Polarized Hepatocytes
    Ann Hubbard; Fiscal Year: 2005
    ..rabs 8, 11 and 17 and the t-SNAREs) as well as candidates identified in Aims #1 B and #2. Our overall goal is to understand the molecular basis of PM protein traffic in polarized hepatocytes. ..
  30. PLATELET DERIVED GROWTH FACTOR IN FOLLICLE DEVELOPMENT
    Christopher Taylor; Fiscal Year: 2002
    ..abstract_text> ..
  31. IDENTIFICATION OF AN ASTHMA SUSCEPTIBILITY GENE ON 3P
    Eugene Bleecker; Fiscal Year: 2004
    ..As part of this project, it will be very important to interact with other funded investigators to determine the impact of each genetic locus and to investigate gene-gene interactions. ..
  32. QUANTITATIVE ASSOCIATION METHODS FOR GENE MAPPING
    Daniel Schaid; Fiscal Year: 2001
    ..The advantages of this proposed research, over those currently used to identify and characterize genes of complex diseases, are that it will offer a more powerful and flexible method to find these types of genes. ..
  33. GENETIC TRACING STRATEGIES FOR THE RAT NERVOUS SYSTEM
    Pietro Sanna; Fiscal Year: 2005
    ..The results of the present R21 will contribute to the development and refinement of strategies for the regulated delivery of recombinant tracers and, in follow-up studies, other reporters such as functional biosensors. ..
  34. GENETIC REGULATION OF IMMUNE MATURATION IN ASTHMA
    Fernando Martinez; Fiscal Year: 2001
    ....
  35. Transgenic Murine Model of Brain Vascular Malformation
    Guo Yuan Yang; Fiscal Year: 2004
    ..This non-tumor angiogenesis rodent preparation will serve as a model of disordered human cerebral angiogenesis, leading relatively quickly to the ability to test new therapeutic approaches for cerebrovascular disorders. ..
  36. MECHANISMS OF CARDIOTOXICITY OF ANTIPSYCHOTIC DRUGS
    David Flockhart; Fiscal Year: 2001
    ....
  37. SCLERODERMA LUNG STUDY
    Donald Tashkin; Fiscal Year: 2003
    ..abstract_text> ..
  38. DIETARY NUTRIENTS AS MODULATORS OF HEPATIC METABOLISM
    Michael Pagliassotti; Fiscal Year: 2001
    ..Finally, to explain the decreased Km of G-6Pase for G6P during HS diet, and increased Vmax during HF diet, kinetics of this enzyme will be measured in the intact and disrupted microsomes. ..
  39. LEPTIN ACTION ON HYPOTHALAMIC PEPTIDES GOVERNING FEEDING
    Abhiram Sahu; Fiscal Year: 2001
    ..These studies will further our understanding of leptin signaling in the hypothalamus in relation to feeding, and therefore will be relevant to the development of therapeutic approaches to eating disorders. ..
  40. CHEMOKINE BIOMARKERS OF DIISOCYANATE OCCUPATIONAL ASTHMA
    David Bernstein; Fiscal Year: 2002
    ..abstract_text> ..
  41. CARE Network - Madison Clinical Center
    ROBERT LEMANSKE; Fiscal Year: 2008
    ..abstract_text> ..
  42. Dietary supplementation with glucan enhances immune fn
    David Williams; Fiscal Year: 2002
    ..At the successful conclusion of this research e will have established what, if any, effect dietary supplementation with glucan has on modulating immunocompetence arid whether oral glucans will increase resistance to infectious diseases. ..
  43. Human Hematopoietic Cell Transformation by BCR/ABL
    Ravi Bhatia; Fiscal Year: 2008
    ..These studies are expected to result in improved understanding of mechanisms critical for human progenitor transformation in CML and guide rational development of additional mechanism-based therapies. ..
  44. Trypansoma cruzi-induced host cell signaling responses
    Barbara Burleigh; Fiscal Year: 2009
    ..cruzi infective process. It is the understanding of these basic processes that will guide our efforts toward effective prevention and control of Chagas'disease. ..
  45. Pathogenic Mechanism of Polycystic Kidney Disease
    Yumay Chen; Fiscal Year: 2010
    ..Our studies will provide novel insight into the molecular pathogenesis of PKD. They will help explain why cysts progress at different rates and how therapies to slow the progression of PKD can be designed rationally. ..
  46. Asthma Clinical Research Network-Washington University
    Mario Castro; Fiscal Year: 2007
    ..We propose that it is only through such a collaboration that important questions regarding current and novel therapies and management of asthma can be answered. ..
  47. Akt1 and erbB2 - New Molecular Targets for Hormone Resistance in Breast Cancer
    Adriana Stoica; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  48. REGULATION OF THE CORPUS LUTEUM
    Anthony Zeleznik; Fiscal Year: 2003
    ..abstract_text> ..
  49. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  50. Airway Remodeling in Severe Asthma
    Mario Castro; Fiscal Year: 2005
    ..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
  51. Effects of Alcohol on the BNST-Cellular Neurobiology
    Pietro Sanna; Fiscal Year: 2005
    ..abstract_text> ..
  52. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....
  53. AMT Dual Camera System
    Ann Hubbard; Fiscal Year: 2005
    ..The addition of this digital imaging system to our TEM will increase productivity and provide high-contrast, efficient imaging for our research. ..
  54. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
    ..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
  55. Pycnogenol for Treatment of Arm Lymphedema
    Paul Hutson; Fiscal Year: 2004
    ..In summary, the successful completion of this research can be expected to provide an alternative therapy and new instruments for treating and measuring lymphedema. ..
  56. ESTROGEN METABOLITES EFFECTS ON BONE
    Russell Turner; Fiscal Year: 2002
    ..abstract_text> ..
  57. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT RAND SUTHERLAND; Fiscal Year: 2010
    ..End of Abstract) ..
  58. Etiology and Treatment of Parathyroid Bone Disease
    Russell Turner; Fiscal Year: 2005
    ..Since PDGF antagonists such as trapidil are available for human use, positive results could be quickly extended to clinical practice. ..
  59. DOSE RESPONSE EFFECTS OF ALCOHOL ON BONE METABOLISM
    Russell Turner; Fiscal Year: 2006
    ....
  60. Mechanistic basis of myoblast therapy and angiomyogenesis
    Muhammad Ashraf; Fiscal Year: 2009
    ..We believe that the findings of this proposal may eventually lead to achieve better prognosis from skeletal myoblast transplantation in the clinical perspective. ..
  61. ASTHMA CLINICAL RESEARCH NETWORK
    ROBERT LEMANSKE; Fiscal Year: 2002
    ....
  62. CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMA
    ROBERT LEMANSKE; Fiscal Year: 2001
    ..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
  63. RNAi Technology to Study In Vivo Muscle Metabolism
    LAURIE GOODYEAR; Fiscal Year: 2005
    ..Ultimately, this approach could provide the basis for treatment of skeletal muscle insulin resistance and other chronic muscle diseases such as the dystrophies. ..
  64. MECHANISMS OF SMOOTH MUSCLE HYPERREACTIVITY ON ASTHMA
    Prescott Woodruff; Fiscal Year: 2006
    ..The candidate will complement these studies with a curriculum of advanced training in methods for the design and analysis of gene expression studies in human subjects. ..
  65. Neuro-Immune Interactions in Developing Airways
    Gary Larsen; Fiscal Year: 2005
    ..These studies of developmental airway biology in mammalian species allow definition of neuro-immune mechanisms that may have relevance to events that occur in infants and small children. ..
  66. Analysis of 5'UTR-Mediated Regulation of p53 Expression
    Philip Lazarus; Fiscal Year: 2006
    ..abstract_text> ..
  67. AMPK: Impact on Metabolism and Disease
    LAURIE GOODYEAR; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  68. Treatment of Severe Persistent Asthma
    ROBERT LEMANSKE; Fiscal Year: 2007
    ..abstract_text> ..