vecuronium bromide

Summary

Summary: Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.

Top Publications

  1. ncbi The effect of ulinastatin pre-treatment on vecuronium-induced neuromuscular block in patients with hepatic cirrhosis
    Y Saitoh
    Department of Anaesthesiology, Fukushima Medical University School of Medicine, Japan
    Anaesthesia 57:218-22. 2002
  2. ncbi [Overdose of vecuronium during general anesthesia to an infant]
    Hiroto Ohata
    Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu
    Masui 54:298-300. 2005
  3. ncbi Gabexate mesilate hastens recovery from vecuronium-induced neuromuscular blockade
    H Hattori
    Fukushima Medical University School of Medicine, Department of Anesthesiology, Fukushima City, Fukushima, Japan
    Eur J Anaesthesiol 22:20-4. 2005
  4. ncbi [Clinical study of vecuronium maintenance speed in trigeminal microvascular decompression surgery]
    Masahiko Onaka
    Department of Anesthesia, Shiroyama Hospital, Habikino
    Masui 54:376-80. 2005
  5. ncbi Drugs to facilitate recovery of neuromuscular blockade and muscle strength
    Yuhji Saitoh
    Department of Anesthesiology, Satte General Hospital, 4 14 24 Higashi, Satte 340 0114, Japan
    J Anesth 19:302-8. 2005
  6. pmc Potency of nondepolarizing muscle relaxants on muscle-type acetylcholine receptors in denervated mouse skeletal muscle
    Hong Wang
    Department of Anesthesiology, First People s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China
    Acta Pharmacol Sin 31:1541-6. 2010
  7. ncbi The potency of new muscle relaxants on recombinant muscle-type acetylcholine receptors
    Matthias Paul
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0542, USA
    Anesth Analg 94:597-603; table of contents. 2002
  8. ncbi A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism
    Edmund Jooste
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P and S Box 46, New York, New York 10032, USA
    Anesthesiology 98:906-11. 2003
  9. ncbi Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor
    Edmund H Jooste
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Anesthesiology 103:1195-203. 2005
  10. ncbi Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium
    C H Kindler
    Department of Anesthesia, University of California, San Francisco 94143 0542, USA
    Anesthesiology 92:821-32. 2000

Research Grants

Detail Information

Publications237 found, 100 shown here

  1. ncbi The effect of ulinastatin pre-treatment on vecuronium-induced neuromuscular block in patients with hepatic cirrhosis
    Y Saitoh
    Department of Anaesthesiology, Fukushima Medical University School of Medicine, Japan
    Anaesthesia 57:218-22. 2002
    ..After pretreatment with ulinastatin, the speed of recovery from neuromuscular block in patients with cirrhosis becomes similar to that seen in healthy patients...
  2. ncbi [Overdose of vecuronium during general anesthesia to an infant]
    Hiroto Ohata
    Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu
    Masui 54:298-300. 2005
    ..Finally, he could recover with no adverse effect. To predict the optimal dose of a non-depolarizing muscle relaxant to a pediatric patient, routine monitoring of neuromuscular block is effective and essential...
  3. ncbi Gabexate mesilate hastens recovery from vecuronium-induced neuromuscular blockade
    H Hattori
    Fukushima Medical University School of Medicine, Department of Anesthesiology, Fukushima City, Fukushima, Japan
    Eur J Anaesthesiol 22:20-4. 2005
    ....
  4. ncbi [Clinical study of vecuronium maintenance speed in trigeminal microvascular decompression surgery]
    Masahiko Onaka
    Department of Anesthesia, Shiroyama Hospital, Habikino
    Masui 54:376-80. 2005
    ..Patients receiving chronic carbamazepine therapy may be resistant to vecuronium. The purpose of this study was to determine maintenance speed of vecuronium in trigeminal microvascular decompression surgery...
  5. ncbi Drugs to facilitate recovery of neuromuscular blockade and muscle strength
    Yuhji Saitoh
    Department of Anesthesiology, Satte General Hospital, 4 14 24 Higashi, Satte 340 0114, Japan
    J Anesth 19:302-8. 2005
    ..Therefore, recovery from neuromuscular blockade is hastened. Nicorandil enhances membrane K+ conductance in skeletal muscle and increases contraction of the skeletal muscle. Thus, nicorandil quickens recovery from neuromuscular blockade...
  6. pmc Potency of nondepolarizing muscle relaxants on muscle-type acetylcholine receptors in denervated mouse skeletal muscle
    Hong Wang
    Department of Anesthesiology, First People s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China
    Acta Pharmacol Sin 31:1541-6. 2010
    ..to investigate the changing resistance to nondepolarizing muscle relaxants (NDMRs) during the first month after denervation...
  7. ncbi The potency of new muscle relaxants on recombinant muscle-type acetylcholine receptors
    Matthias Paul
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94143 0542, USA
    Anesth Analg 94:597-603; table of contents. 2002
    ..Different drug-receptor affinities of the tested NDMRs contribute to the differences in clinical dose requirements of these drugs needed to achieve appropriate muscle relaxation...
  8. ncbi A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism
    Edmund Jooste
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, P and S Box 46, New York, New York 10032, USA
    Anesthesiology 98:906-11. 2003
    ..g., intubation) can result in the massive release of acetylcholine to act on unopposed M3 muscarinic receptors in airway smooth muscle, thereby facilitating bronchoconstriction...
  9. ncbi Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor
    Edmund H Jooste
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Anesthesiology 103:1195-203. 2005
    ..Despite its withdrawal from clinical use, it is imperative that the mechanism by which bronchospasm occurred is understood so that new muscle relaxants introduced to clinical practice do not share these same detrimental airway effects...
  10. ncbi Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium
    C H Kindler
    Department of Anesthesia, University of California, San Francisco 94143 0542, USA
    Anesthesiology 92:821-32. 2000
    ....
  11. ncbi Prolonged relaxant effects of vecuronium in patients with deliberate hypermagnesemia: time for caution in cesarean section
    Akiko Yoshida
    Department of Anesthesiology, Tohoku University Hospital, Sendai, Japan
    J Anesth 20:33-5. 2006
    ..Our cases underscore the need for anesthesiologists as well as obstetricians to be aware of the prolongation of the action of nondepolarizing muscle relaxants as a result of magnesium treatment...
  12. ncbi The effect of local anesthetics on the inhibition of adult muscle-type nicotinic acetylcholine receptors by nondepolarizing muscle relaxants
    Hong Wang
    Department of Anesthesiology, First People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Eur J Pharmacol 630:29-33. 2010
    ....
  13. pmc Different magnitude of resistance to nondepolarizing muscle relaxants in the denervated mouse skeletal muscle
    Hong Wang
    Department of Anesthesiology, First People s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
    Acta Pharmacol Sin 31:399-404. 2010
    ..To test the hypothesis that different magnitude of resistance of denervated skeletal muscle to nondepolarizing muscle relaxants (NDMRs) is related to their varying potencies at epsilon-AChR and gamma-AChR...
  14. ncbi Postoperative residual block after intermediate-acting neuromuscular blocking drugs
    A H Hayes
    Department of Anaesthetics and Intensive Care Medicine, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK
    Anaesthesia 56:312-8. 2001
    ..Although the residual block is relatively short lasting, it may occasionally be prolonged, requiring close observation and monitoring of such patients in the recovery ward...
  15. ncbi Prolongation of rapacuronium neuromuscular blockade by clindamycin and magnesium
    Paul A Sloan
    University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Anesth Analg 94:123-4, table of contents. 2002
    ..Even when using "short-acting" muscle relaxants, the anesthesiologist must routinely monitor the neuromuscular function...
  16. ncbi Neuromuscular block with vecuronium reduces the rapidly extracted auditory evoked potentials index during steady state anesthesia
    Sheng jin Ge
    Department of Anesthesiology, Shanghai Jiaotong University Affiliated Shanghai First People Hospital, Shanghai, China
    Can J Anaesth 50:1017-22. 2003
    ..During clinical monitoring, vecuronium appeared to reduce the rapidly extracted auditory evoked potentials index (A-line ARX index or AAI) to some extent. A prospective and randomized study was designed to analyze this phenomenon...
  17. ncbi The effect of epidural bupivacaine on induction and maintenance doses of propofol (evaluated by bispectral index) and maintenance doses of fentanyl and vecuronium
    Anil Agarwal
    Type IV 48, SGPGILucknow 226 014, India
    Anesth Analg 99:1684-8, table of contents. 2004
    ..05). We conclude that epidural bupivacaine given before induction of anesthesia reduces the requirement of propofol, fentanyl, and vecuronium during general anesthesia...
  18. ncbi [Influence of epidural lidocaine injection on vecuronium-induced neuromuscular blockade]
    Kazuhiko Munakata
    Department of Anesthesiology, Nihon University School of Medicine, Tokyo 173 0032
    Masui 53:1377-80. 2004
    ..We investigated vecuronium-induced neuromuscular blockade in patients with continuous epidural lidocaine injection and those without epidural lidocaine...
  19. ncbi Assessment of neuromuscular and haemodynamic effects of cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia in elderly patients
    G T Keles
    Department of Anaesthesiology and Reanimation, Faculty of Medicine, University of Celal Bayar, Manisa, Turkey
    Eur J Anaesthesiol 21:877-81. 2004
    ..Neuromuscular block times, quality of muscle relaxation for tracheal tube insertion, and the haemodynamic effects after cisatracurium and vecuronium under sevoflurane-remifentanil anaesthesia were compared in elderly patients...
  20. ncbi [Effects of modified anaesthesia for patients undergoing brain artery aneurysm repair operation]
    Anna Grabowska-Gaweł
    Katedra i Klinika Anestezjologii i Intensywnej Terapii AM w Bydgoszczy
    Pol Merkur Lekarski 17:248-51. 2004
    ..divided into two groups: thiopental, atracurium besilate and fentanyl group (group I; n= 27) and propofol, vecuronium bromide and fentanyl in a continuous intravenous administration group (group II; n=28)...
  21. ncbi [Monitoring of consciousness with BIS during induction of anesthesia. Which muscle relaxant?]
    S Gazzanelli
    Dipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Universita degli Studi La Sapienza, Roma
    G Chir 26:163-9. 2005
    ..The BIS-index data show that an opiate as Fentanyl is advisable with associations Cisatracurium/Propofol or Vecuronium/Propofol. It is possible to use in these cases a drip infusion to avoid the risk of awareness during intubation...
  22. ncbi Juvenile hyaline fibromatosis
    N Mehmet Mutlu
    Paediatr Anaesth 14:798-9. 2004
  23. ncbi General anesthesia and postoperative pain management in analgesic intolerant patients with/without asthma: is it safe?
    V Celiker
    Department of Anesthesiology, Hacettepe University, School of Medicine, Ankara, Turkey
    Allergol Immunopathol (Madr) 32:64-8. 2004
    ..These patients are frequently referred to adult allergy clinics for preoperative evaluation for possible analgesic cross reactivity and intolerance to anesthetic agents...
  24. ncbi Effects of remifentanil and fentanyl on intraocular pressure during the maintenance and recovery of anaesthesia in patients undergoing non-ophthalmic surgery
    S M Sator-Katzenschlager
    University of Vienna, Department of Anaesthesiology and General Intensive Care B, Vienna, Austria
    Eur J Anaesthesiol 21:95-100. 2004
    ..To compare the effects of remifentanil and fentanyl on intraocular pressure during the maintenance and recovery of anaesthesia in patients undergoing elective non-ophthalmic surgery...
  25. ncbi Performance of the rapidly extracted auditory evoked potentials index to detect the recovery and loss of wakefulness in anesthetized and paralyzed patients
    S J Ge
    Department of Anesthesiology, Shanghai First People s Hospital, Shanghai, China
    Acta Anaesthesiol Scand 47:466-71. 2003
    ..A prospective study was designed to assess the performance of AAI to detect the recovery and loss of wakefulness in anesthetized and paralyzed patients...
  26. ncbi Ephedrine fails to accelerate the onset of neuromuscular block by vecuronium
    Ryu Komatsu
    Department of Anesthesiology, Tokyo Women s Medical University, Tokyo, Japan
    Anesth Analg 97:480-3, table of contents. 2003
    ..The combination of ephedrine and vecuronium thus cannot be substituted for rapid-acting nondepolarizing muscle relaxants...
  27. ncbi The dose effect of ephedrine on the onset time of vecuronium
    Kyo S Kim
    Department of Anesthesiology, Hanyang University Hospital, 17 Haengdang dong, Sungdong gu, Seoul 133 792, Korea
    Anesth Analg 96:1042-6, table of contents. 2003
    ..We conclude that ephedrine 70 microg/kg given before the induction of anesthesia improved intubating conditions at 2 min after vecuronium, probably by increased cardiac output without significant adverse hemodynamic effects...
  28. ncbi Neural nets and prediction of the recovery rate from neuromuscular block
    O A P Santanen
    Helsinki University Central Hospital, Department of Anaesthesia and Intensive Care Medicine, Eye ENT Clinic, Finland
    Eur J Anaesthesiol 20:87-92. 2003
    ....
  29. ncbi General anaesthesia for lobectomy in an 8-year-old child with Kartagener's syndrome
    H Sahajananda
    Department of Anaesthesiology, St John s Medical College and Hospital, Bangalore, Karnataka, India
    Paediatr Anaesth 13:714-7. 2003
    ..We describe the case of a young boy who underwent lobectomy under general anaesthesia using a single lumen tube. Anaesthetic implications of this syndrome are mentioned. Key points in the management of anaesthesia in KGS are discussed...
  30. ncbi The ED(95) of end-tidal sevoflurane concentration for the smooth exchange of the tracheal tube for a laryngeal mask airway is 2.97%
    Koichi Takita
    Department of Anesthesiology Critical Care Medicine Hokkaido University Graduate School of Medicine Sapporo Japan
    Can J Anaesth 50:184-8. 2003
    ..This study was conducted to determine the end-tidal concentration of sevoflurane that prevented response to this exchange in 50% patients (MAC(TT/LMA))...
  31. ncbi The effect of neuromuscular blockade on the efficiency of mask ventilation of the lungs
    M W P Goodwin
    Nuffield Department of Anaesthetics, The John Radcliffe Hospital, Oxford OX3 9 DU, UK
    Anaesthesia 58:60-3. 2003
    ..47 (0.13)] and after [0.45 (0.13)] neuromuscular blockade. We conclude that neuromuscular blockade does not affect the efficiency of mask ventilation in patients with normal airways...
  32. ncbi Effect of maintenance bolus on the recovery profile of a short-acting nondepolarizing muscle relaxant
    Xiaoguang Chen
    Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9068, USA
    J Clin Anesth 14:500-4. 2002
    ..To evaluate the effect of different maintenance boluses of a short-acting nondepolarizing neuromuscular blocking drug on its spontaneous recovery profile during anesthesia...
  33. ncbi Systolic blood pressure, not BIS, is associated with movement during laryngoscopy and intubation
    Velislav Slavov
    Du service d anesthésie réanimation Hôpital Henri Mondor, AP HP et Université Paris XII, Creteil, France
    Can J Anaesth 49:918-21. 2002
    ..To compare bispectral index (BIS) values to hemodynamic variations, in order to evaluate adequacy of anesthesia during orotracheal intubation with muscle relaxants...
  34. ncbi Anaesthetic management of a strabismus patient with phenylketonuria
    Didem Dal
    Paediatr Anaesth 13:740-1. 2003
  35. ncbi Anaesthesia for a girl with severe hypertension due to 11 beta-hydroxylase deficiency
    T Okamoto
    Anaesth Intensive Care 31:596. 2003
  36. ncbi Pharmacokinetics of propofol in elderly coronary artery bypass graft patients under total intravenous anesthesia
    Norifumi Morikawa
    Department of Clinical Pharmacy, Oita Medical University, Japan
    Biol Pharm Bull 25:813-5. 2002
    ..0 microg/ml, and the half-life may be longer than previously reported values in adult patients...
  37. ncbi Anaesthetic management of an infant with Conradi's syndrome
    Mehmet Hascalik
    Paediatr Anaesth 13:841-2. 2003
  38. ncbi Double-blind comparison of the variability in spontaneous recovery of cisatracurium- and vecuronium-induced neuromuscular block in adult and elderly patients
    F K Pühringer
    Klinikum am Steinenberg, Reutlingen, Germany
    Acta Anaesthesiol Scand 46:364-71. 2002
    ..This study was designed to compare variability in the offset of two neuromuscular blocking agents with different elimination pathways...
  39. ncbi Tracheal intubation conditions and cardiovascular effects after modified rapid-sequence induction with sevoflurane-rapacuronium versus propofol-rapacuronium
    Mohammad I El-Orbany
    Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA
    J Clin Anesth 14:115-20. 2002
    ..To compare intubation conditions and hemodynamic effects resulting from rapid-sequence induction of anesthesia with sevoflurane-rapacuronium and propofol-rapacuronium...
  40. ncbi Effect of milrinone on vecuronium-induced neuromuscular block
    H Nakajima
    Department of Anaesthesiology, Fukushima Medical University School of Medicine, 1, Hikarigaoka, Fukushima City, Fukushima, 960 1295, Japan
    Anaesthesia 58:643-6. 2003
    ..We conclude that milrinone delays the onset of neuromuscular blockade but hastens its recovery in anaesthetised patients receiving vecuronium...
  41. ncbi The presence of working memory without explicit recall in a critically ill patient
    Mehmet S Ozcan
    Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida 32610 0254, USA
    Anesth Analg 98:469-70, table of contents. 2004
    ..This experience suggests that working memory demonstrated when BIS values are less than 60 is unlikely to lead to recall...
  42. ncbi Recovery from vecuronium is delayed in patients with hypercholesterolemia
    Yuhji Saitoh
    Department of Anesthesiology, Satte General Hospital, 4 14 24, Higashi, Satte City, Saitama, 340 0114, Japan
    Can J Anaesth 53:556-61. 2006
    ..To examine the effects of hypercholesterolemia with respect to onset time and recovery from vecuronium-induced neuromuscular block...
  43. ncbi Multidrug intravenous anesthesia for children undergoing MRI: a comparison with general anesthesia
    Ahmed A Shorrab
    Department of Anesthesia, Faculty of Medicine, University of Mansoura, Mansoura, Egypt
    Paediatr Anaesth 17:1187-93. 2007
    ..This regimen was compared with general anesthesia in a randomized comparative study. Outcome measures were safety, side effects and recovery variables in addition to adverse events in relation to age strata...
  44. ncbi Epidurally administered mepivacaine delays recovery of train-of-four ratio from vecuronium-induced neuromuscular block
    T Suzuki
    Department of Anaesthesiology, Surugadai Nihon University Hospital, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo, 101 8309, Japan
    Br J Anaesth 99:721-5. 2007
    ..The aim of this study was to examine the efficacy of epidurally administered mepivacaine on recovery from vecuronium-induced neuromuscular block...
  45. ncbi [Neuromuscular blocking effects of Org 9426 (rocuronium bromide); a comparative study with vecuronium bromide in Japanese patients]
    Koh Shingu
    Department of Anesthesiology, Kansai Medical University, Moriguchi
    Masui 55:1140-8. 2006
    Efficacy and safety of Org 9426 were compared with those of vecuronium bromide in Japanese patients.
  46. ncbi Time course of systolic and diastolic blood pressure decreases during the preintubation period of anesthesia induction: modeling with a logistic function
    Ju Mizuno
    Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Clin Anesth 19:497-505. 2007
    ..To investigate whether systolic (SBP) and diastolic blood pressure (DBP) decreases during the preintubation period could be expressed as 4-parameter logistic and cubic functions giving S-shaped curves...
  47. ncbi Prolonged cardiac arrest unveiled silent sick sinus syndrome during general and epidural anesthesia
    Ryosuke Ishida
    Department of Anesthesiology, Shimane University School of Medicine, 89 1 Enya cho, Izumo, Shimane, 693 8501, Japan
    J Anesth 21:62-5. 2007
    ..We propose that the possible existence of SSS should be kept in mind even in a patient who shows no abnormalities on routine preoperative examination, especially in those in whom vagomimetic anesthetic methods are used...
  48. ncbi Anesthesia for congenital insensitivity to pain with anhidrosis
    Ozgur Canbay
    Paediatr Anaesth 17:190-2. 2007
  49. ncbi Anesthetic management of a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) during laparotomy
    Nobuko Sasano
    Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8622, Japan
    J Anesth 21:72-5. 2007
    ..It is important to maintain normothermia in MELAS patients in order to avoid further mitochondrial metabolic depression...
  50. ncbi Preoperative ultra short-term entropy predicts arterial blood pressure fluctuation during the induction of anesthesia
    Yoshihiro Fujiwara
    Department of Anesthesiology, Aichi Medical University School of Medicine, Japan
    Anesth Analg 104:853-6. 2007
    ..In this study, we sought to determine whether the preoperative nonlinear index of heart rate variability, ultra short-term entropy (UsEn), could predict cardiovascular responses to the induction of general anesthesia...
  51. ncbi TOF count at corrugator supercilii reflects abdominal muscles relaxation better than at adductor pollicis
    K Kirov
    Anaesthesia and Intensive Care Department, Jean Verdier University Hospital of Paris, 93143 Bondy Cedex, France
    Br J Anaesth 98:611-4. 2007
    ..We compared the visual estimation of NMT at CSC and AP with electromyographic measurements of AB during recovery from a vecuronium block...
  52. ncbi Comparisons of the dose-response and recovery time course of vecuronium and atracurium in anesthetized chinese adult patients
    Fu Shan Xue
    Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beyijng, PR of China
    Acta Anaesthesiol Taiwan 45:9-14. 2007
    ....
  53. ncbi Magnesium sulphate as an adjuvant to total intravenous anesthesia in septorhinoplasty: a randomized controlled study
    Pelin Cizmeci
    Department of Anesthesiology and Reanimation, Gazi University School of Medicine, 06500, Besevler, Ankara, Turkey
    Aesthetic Plast Surg 31:167-73. 2007
    ....
  54. ncbi Post-tetanic count at adductor pollicis is a better indicator of early diaphragmatic recovery than train-of-four count at corrugator supercilii
    G Dhonneur
    Anaesthesia and Intensive Care Department, Jean Verdier University Hospital of Paris, 93143 Bondy Cedex, France
    Br J Anaesth 99:376-9. 2007
    ....
  55. ncbi Residual curarization in the recovery room after vecuronium
    C Baillard
    Department of Anaesthesiology, University Hospital, Bobigny, France
    Br J Anaesth 84:394-5. 2000
    ..We conclude that it is necessary to antagonize residual block produced by vecuronium...
  56. ncbi The ex utero intrapartum treatment procedure: anesthetic considerations
    Leon C Chang
    Departments of Anesthesiology and Reproductive Medicine, UCSD Medical Center, University of California San Diego, 200 W Arbor Drive, San Diego, CA 92103, USA
    Arch Gynecol Obstet 277:83-5. 2008
    ..We present a case of an uneventful EXIT procedure and include a discussion of the anesthetic goals for this operation...
  57. ncbi Consensus guidelines for sustained neuromuscular blockade in critically ill children
    Stephen Playfor
    Paediatric Intensive Care Unit, Royal Manchester Children s Hospital, Pendlebury, Manchester, UK
    Paediatr Anaesth 17:881-7. 2007
    ..However, similar clinical practice guidelines have not previously been produced for the critically ill pediatric patient...
  58. ncbi Anesthesia in a child with newly diagnosed Hypertrophic Cardiomyopathy
    Serge Kaplanian
    Department of Anesthesia, Princess Margaret Hospital for Children, Perth, WA, Australia
    Paediatr Anaesth 16:1080-3. 2006
    ..Here, we describe the safe use of an anesthetic technique for insertion of an implantable cardioverter-defibrillator that ensured strict hemodynamic stability and modest bradycardia...
  59. ncbi Normalization of acceleromyographic train-of-four ratio by baseline value for detecting residual neuromuscular block
    T Suzuki
    Department of Anesthesiology, Surugadai Nihon University Hospital, 1 8 13, Kanda Surugadai, Chiyoda ku, Tokyo 101 8309, Japan
    Br J Anaesth 96:44-7. 2006
    ....
  60. ncbi The effects of volatile anesthetics on intraoperative monitoring of myogenic motor-evoked potentials to transcranial electrical stimulation and on partial neuromuscular blockade during propofol/fentanyl/nitrous oxide anesthesia in humans
    Kenichi Sekimoto
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi City 3718511, Japan
    J Neurosurg Anesthesiol 18:106-11. 2006
    ..0 MAC, with the effect being less in HAL at 0.5 MAC. We have shown that HAL had a lesser suppressive effect on MEPs than either ISO or SEV at 0.5 MAC, which was partially due to a lesser degree of NMB...
  61. ncbi Anesthetic management of a patient with a history of Batista procedure for dilated cardiomyopathy undergoing gastric surgery
    Aki Honda
    Department of Anesthesiology, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagimahara 228 8555, Japan
    J Anesth 20:227-30. 2006
    ..Safe anesthetic management was achieved under the guidance of a Swan-Ganz catheter without inducing overreduction of afterload or excessive preload...
  62. ncbi Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers
    G Cammu
    Department of Anaesthesiology and Critical Care Medicine, Onze Lieve Vrouw Clinic, Moorselbaan 164, 9300 Aalst, Belgium
    Br J Anaesth 100:373-9. 2008
    ..v. doses of sugammadex administered simultaneously with rocuronium or vecuronium to anaesthetized and non-anaesthetized healthy volunteers...
  63. ncbi The postoperative cardiovascular arrest of a 5-year-old male: an initial presentation of Duchenne's muscular dystrophy
    Michael Girshin
    Department of Anesthesiology, Montefiore Medical Center, New York, NY 10467, USA
    Paediatr Anaesth 16:170-3. 2006
    ..We present the case of a 5-year-old boy whose muscular dystrophy was discovered following a fatal, perioperative cardiac arrest in the postanesthesia care unit...
  64. ncbi The effects of propofol, isoflurane and sevoflurane on vecuronium infusion rates for surgical muscle relaxation in dogs
    Shotaro Nagahama
    Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Anaesth Analg 33:169-74. 2006
    ..g. thoracotomy or laparotomy, in dogs anaesthetized with a CRI of fentanyl and either propofol, isoflurane or sevoflurane...
  65. ncbi [Effects of mechanical ventilation and controlled spontaneous respiration on pulmonary function during short duration of general anesthesia with tracheal intubation]
    Hai Jiang
    Department of Anesthesia, Sixth Affiliated Hospital, Sun Yat Sen University, Guangzhou 510655, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2211-4. 2009
    ..To evaluate the effects of mechanical ventilation on pulmonary function during short duration of general anesthesia with tracheal intubation, and assess the safety of controlled spontaneous respiration during general anesthesia...
  66. ncbi The Thai Anesthesia Incidents Study (THAI study) of ambulatory anesthesia: II. Anesthetic profiles and adverse events
    Yodying Punjasawadwong
    Department of Anesthesiology, Chiang Mai University, Chiang Mai 50200, Thailand
    J Med Assoc Thai 91:188-95. 2008
    ..There is a continuing trend to have more elective surgery performed on an outpatient basis...
  67. ncbi Assessment of the potential for displacement interactions with sugammadex: a pharmacokinetic-pharmacodynamic modelling approach
    Alex Zwiers
    Schering Plough Research Institute, a Division of MSD, Newhouse, Scotland, UK
    Clin Drug Investig 31:101-11. 2011
    ..Cyclodextrins are known to form inclusion complexes with other compounds...
  68. ncbi Mechanisms of activation of human mast cells and basophils by general anesthetic drugs
    G Marone
    Department of Medicine, University of Naples Federico II, School of Medicine, Italy
    Ann Fr Anesth Reanim 12:116-25. 1993
    ..From the results obtained with the in vitro model described here, it is clear that new drugs promising for the anesthesiologic arena should be tested in vitro before their potential histamine-releasing activity is experienced in vivo...
  69. ncbi [Desflurane versus isoflurane in geriatric patients. A comparison of psychomotor and postoperative well-being following abdominal surgical procedures]
    J Motsch
    Klinik fur Anaesthesiologie, Ruprecht Karls Universitat Heidelberg
    Anasthesiol Intensivmed Notfallmed Schmerzther 33:313-20. 1998
    ..4), suggesting excellent intraoperative control of anaesthesia and rapid emergence and recovery from anaesthesia. However, only limited experience is available in geriatric patients undergoing major abdominal surgery...
  70. ncbi Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways
    Edmund Jooste
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 106:763-72. 2007
    ..Although interactions of muscle relaxants with muscarinic receptors have been extensively characterized in vitro, limited information is available on their potential interactions with airway tone in vivo...
  71. ncbi [Ocular circulatory changes in halothane-nitrous oxide intubation anesthesia with special reference to arterial CO2 partial pressure. I. Phenomenology of changes]
    V Hessemer
    Augenklinik Justus Liebig Universität Giessen
    Klin Monbl Augenheilkd 199:346-55. 1991
    ..1 microliters/min, respectively; and in a PCO2 range between 20 and 25 mmHg (forced hyperventilation), they averaged 0.21 microliter and 22.8 microliters/min, respectively. All other variables were not dependent on the PCO2 level...
  72. ncbi [Droperidol and dimenhydrinate alone or in combination for prevention of postoperative nausea and vomiting]
    L H Eberhart
    Klinik für Anästhesiologie Universität Ulm
    Anasthesiol Intensivmed Notfallmed Schmerzther 36:290-5. 2001
    ..Thus, the aim of this randomised controlled and double-blinded study was to evaluate the antiemetic efficacy and the side effects of such a combination therapy...
  73. ncbi Intravenous nicorandil prevents thiamylal-fentanyl-induced bronchoconstriction in humans
    Zen ichiro Wajima
    Department of Anesthesia, Chiba Hokusoh Hospital, Nippon Medical School, Inba gun, Japan
    Crit Care Med 31:485-90. 2003
    ..However, no clinical data on the bronchorelaxant effects of this drug have been published. The aim of this study was to investigate whether intravenous nicorandil prevents thiamylal-fentanyl-induced bronchoconstriction...
  74. ncbi [Motor function during patient-controlled analgesia via a lumbar epidural catheter after major abdominal surgery. Ropivacaine-sufentanil vs. bupivacaine-sufentanil]
    L H J Eberhart
    Universitätsklinik für Anästhesie und Intensivtherapie Philipps Universität Marburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 37:216-21. 2002
    ..The aim of the present study was to investigate postoperative motoric impairment during patient-controlled analgesia after major abdominal surgery with ropivacaine-sufentanil and bupivacaine-sufentanil via a lumbar epidural catheter...
  75. ncbi [Intraocular pressure values in intubation anesthesia in patients with and without chronic open angle glaucoma]
    P C Hoffmann
    Augenklinik, Kreiskrankenhaus Bad Hersfeld
    Klin Monbl Augenheilkd 212:23-8. 1998
    ..CONCLUSIONS: General anesthesia lowers IOP to the advantage of intraocular surgery. There is no statistically significant difference in pressure change relative to baseline value in eyes with and without primary open angle glaucoma...
  76. ncbi Anesthesia for laparoscopic general surgery. A special review
    M S Takrouri
    Department of Anesthesia, College of Medicine, King Saud University, King Khalid University Hospital KKUH
    Middle East J Anaesthesiol 15:39-62. 1999
    ....
  77. ncbi Lightwand intubation does not reduce the increase in intraocular pressure associated with tracheal intubation
    A Casati
    Department of Anesthesiology, University of Milan, Italy
    J Clin Anesth 11:216-9. 1999
    ..To evaluate the changes in hemodynamic variables and intraocular pressure (IOP) after tracheal intubation using either lightwand or direct-vision laryngoscopy techniques...
  78. ncbi [The use of curare-like agents in resuscitation]
    A Suppini
    Departement d Anesthesie Reanimation, Hopital d Instruction des Armees Sainte Anne, Toulon, France
    Ann Fr Anesth Reanim 18:341-54. 1999
    ..To analyse current data on use of neuromuscular blocking agents (NBA) in the intensive therapy unit (ITU) patients and to propose practice guidelines...
  79. ncbi Risk factors for sensorineural hearing loss in survivors with severe congenital diaphragmatic hernia
    Kouji Masumoto
    Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka, Japan
    Eur J Pediatr 166:607-12. 2007
    ..blocking agents were also analyzed, including the administration of pancuronium bromide (PB) and vecuronium bromide (VB)...
  80. ncbi [Effect of acupuncture--general anesthesia on hemodynamics in perioperative period of patients undergoing cholecystectomy]
    Yi hong Ding
    Department of Anesthesiology, Shanghai Yueyang Hospital Integrative Chinese and Western Medicine, Shanghai
    Zhongguo Zhong Xi Yi Jie He Za Zhi 28:206-8. 2008
    ..To observe the effect of acupuncture-general anesthesia on hemodynamics in the perioperative period of patients undergoing laparoscopic cholecystectomy...
  81. ncbi Renal safety and extrahepatic defluorination of sevoflurane in hepatic transplantations
    M Kanbak
    Department of Anesthesiology and Reanimation, Hacettepe University Faculty of Medicine, Sihhiye, Ankara 06100, Turkey
    Transplant Proc 39:1544-8. 2007
    ....
  82. ncbi Sugammadex: a review of its use in anaesthetic practice
    Lily P H Yang
    Wolters Kluwer Health, Adis, Auckland, New Zealand
    Drugs 69:919-42. 2009
    ..Nevertheless, sugammadex is a useful addition to the reversal agents commonly employed in anaesthetic practice...
  83. ncbi [Quality comparison of modified neurolept-, balanced and intravenous anesthesia. 1. Study design and patient analysis of the Krefelder study 1992]
    H Harke
    Institut für Anaesthesie, Städtischen Krankenanstalten Krefeld
    Anaesthesist 44:531-7. 1995
    ..42). However, on applying the Munich risk checklist the average number of healthy individuals was 5% to 10% lower than that of the ASA risk classification...
  84. ncbi Extracranial radiosurgery: immobilizing liver motion in dogs using high-frequency jet ventilation and total intravenous anesthesia
    F Yin
    Department of Radiation Oncology, Henry Ford Health System, Detroit, MI 48202 3450, USA
    Int J Radiat Oncol Biol Phys 49:211-6. 2001
    ..The purpose of this study is to quantitatively determine the extent of liver motion in anesthetized dogs with continuous i.v. propofol infusion with or without muscle relaxants and high-frequency jet ventilation...
  85. ncbi Continuous epidural blockade arrests the postoperative decrease in muscle protein fractional synthetic rate in surgical patients
    F Carli
    Department of Anesthesia, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Anesthesiology 86:1033-40. 1997
    ....
  86. ncbi Increased sensitivity to depolarization and nondepolarizing neuromuscular blocking agents in young rat hemidiaphragms
    L P Fortier
    Département d Anesthésiologie, Universite de Montreal, Quebec, Canada
    Anesthesiology 95:478-84. 2001
    ..The purpose of this study was to determine the relative sensitivity of newborn neuromuscular junctions to succinylcholine and five nondepolarizing agents...
  87. ncbi Comparison of tramadol and tramadol/droperidol mixture for patient-controlled analgesia
    K F Ng
    Department of Anaesthesiology, University of Hongkong, Hongkong
    Can J Anaesth 44:810-5. 1997
    ..To compare the analgesic efficacy and side effects of tramadol vs tramadol and droperidol for post-operative patient-controlled analgesia (PCA)...
  88. ncbi A clinical assessment of the Glidescope videolaryngoscope in nasotracheal intubation with general anesthesia
    Fushan Xue
    Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100041, People s Republic of China
    J Clin Anesth 18:611-5. 2006
    ....
  89. ncbi Comparison of the VBM laryngeal tube and laryngeal mask airway for ventilation during manual in-line neck stabilisation
    M Noor Zairul
    Department of Anaesthesiology and Intensive Care, Sarawak General Hospital, Jalan Tun Ahmad Zaidi Adruce, Kuching 93050, Sarawak, Malaysia
    Singapore Med J 47:892-6. 2006
    ..We compared the LT to the laryngeal mask airway (LMA) as an alternative airway management tool in adult patients with unstable neck and who underwent intubation with manual in-line neck stabilisation...
  90. ncbi Reduced-dose rocuronium for day-case tonsillectomy in children where volatile anaesthetics are not used: operating room time saving
    Dubravka Bartolek
    Department of Anaesthesiology and Intensive Care Medicine, University Clinic of Traumatology, Kuhaceva, Zagreb, Croatia
    Paediatr Anaesth 20:47-55. 2010
    ..Mivacurium is the most appropriate NMB for short surgical procedures where NMB drugs were required but is not available in all countries...
  91. ncbi Screening procedure for eight quaternary nitrogen muscle relaxants in blood by high-performance liquid chromatography-electrospray ionization mass spectrometry
    V Cirimele
    Institut de Medecine Legale, 11 rue Humann, F 67085, Strasbourg, France
    J Chromatogr B Analyt Technol Biomed Life Sci 789:107-13. 2003
    ..4 and 0.7 mg vecuronium equivalent/l in blood and urine, respectively). In the second forensic case, blood analysis showed high levels of mebezonium (6.5 mg/l). The developed procedure was found suitable for forensic investigations...
  92. ncbi Does monitoring of post-tetanic count prevent alarms of airway pressure or visible muscle activity during intratracheal jet ventilation? A prospective study with five different neuromuscular blocking agents
    A I Puura
    Medical School, University of Tampere, Finland
    J Clin Monit Comput 16:523-8. 2000
    ..We studied whether monitoring of PTC prevents airway pressure alarms or visible movements of the vocal cords and the abdomen during endolaryngeal procedures (ELPs)...
  93. ncbi Comparison of bolus remifentanil versus bolus fentanyl for blunting cardiovascular intubation responses in children: a randomized, double-blind study
    Quan Yong Yang
    Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Chin Med J (Engl) 122:44-50. 2009
    ....
  94. pmc Sugammadex compared with neostigmine/glycopyrrolate for routine reversal of neuromuscular block: a systematic review and economic evaluation
    F Paton
    Centre for Reviews and Dissemination, University of York, Heslington, York YO10 5DD, UK
    Br J Anaesth 105:558-67. 2010
    ..Further research is required to evaluate the effects of sugammadex on patient safety, predictability of recovery from NMB, patient outcomes, and efficient use of resources...
  95. ncbi Intravenous colforsin daropate, a water-soluble forskolin derivative, prevents thiamylal-fentanyl-induced bronchoconstriction in humans
    Zen ichiro Wajima
    Department of Anesthesia, Chiba Hokusoh Hospital, Chiba, Japan
    Crit Care Med 30:820-6. 2002
    ..No clinical data have been published on the bronchorelaxant effects of this drug. The aim of this study was to investigate whether intravenous colforsin daropate prevents thiamylal-fentanyl-induced bronchoconstriction...
  96. ncbi The incidence and mechanisms of pharyngeal and upper esophageal dysfunction in partially paralyzed humans: pharyngeal videoradiography and simultaneous manometry after atracurium
    E Sundman
    Department of Anesthesiology, Karolinska Hospital and Institute, Stockholm, Sweden
    Anesthesiology 92:977-84. 2000
    ..The secondary objective was to evaluate the effect of atracurium on pharyngeal function...
  97. ncbi The effect of scalp block and local infiltration on the haemodynamic and stress response to skull-pin placement for craniotomy
    Sukran Geze
    Karadeniz Technical University, Medical Faculty, Farabi Hospital, Department of Anesthesiology, Trabzon, Turkey
    Eur J Anaesthesiol 26:298-303. 2009
    ..We compared the effects of scalp-nerve block, infiltration anaesthesia, and routine anaesthesia during skull-pin insertion on haemodynamic and stress responses to craniotomy...
  98. ncbi Stress hormone changes in general anesthesia of long duration: isoflurane-nitrous oxide vs sevoflurane-nitrous oxide anesthesia
    Tomoki Nishiyama
    Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, 113 8655 Tokyo, Japan
    J Clin Anesth 17:586-91. 2005
    ..We investigated perioperative changes of stress hormone in these two anesthetic methods with duration of more than 10 hours...
  99. ncbi Small dose of prostaglandin E(1) increases cardiac output without altering blood volume
    H Fukuda
    Department of Anesthesiology and Critical Care, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    J Clin Anesth 13:330-4. 2001
    ..To investigate the effect of small dose of intravenous (IV) prostaglandin E(1) (PGE(1)) on blood volume (BV) and cardiac output (CO) by pulse dye-densitometry (PDD) in patients administered isoflurane anesthesia...
  100. ncbi Influence of the cortical electrical activity level during general anaesthesia on the severity of immediate postoperative pain in the morbidly obese
    G M Gurman
    Division of Anaesthesiology, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Acta Anaesthesiol Scand 47:804-8. 2003
    ..The aim of this study was to investigate the relationship between the spectral edge frequency (SEF) during general anaesthesia and the severity of immediate postoperative pain following gastric banding surgery in morbidly obese patients...
  101. pmc Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists
    James P Dilger
    Department of Anesthesiology, Stony Brook University, NY 11794 8480, USA, and Department of Anesthesiology, Surugadai Nihon University Hospital, Kanda, Tokyo, Japan
    Anesthesiology 106:1186-95. 2007
    ..To test the generality of this observation, the authors measured current inhibition by five competitive antagonists on wild-type and mutant acetylcholine receptors...

Research Grants4

  1. PARALYSIS--ITS ANTAGONISM DURING SURGERY AND ANESTHESIA
    Ronald Miller; Fiscal Year: 1990
    ..These studies will facilitate the safe administration of neuromuscular blocking drugs and their antagonists, and will help to avoid adverse effects such as prolonged neuromuscular blockade and postoperative respiratory failure...
  2. ESTROGEN EFFECTS ON CARDIOVASCULAR RESPONSE TO EXERCISE
    Marc Kaufman; Fiscal Year: 2005
    ....
  3. SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONS
    Daniel Sessler; Fiscal Year: 2001
    ..Since the cost of oxygen is trivial and the risks of oxygen administration are low, clinicians will easily be able to implement this treatment once we have demonstrated its benefits. ..
  4. Nitrous Oxide and Wound Infections
    Ozan Akca; Fiscal Year: 2006
    ..Confirming our hypothesis would thus allow clinicians to make a minor modification in anesthetic practice that might reduce the incidence of a complication responsible for considerable perioperative morbidity and cost. ..