oxandrolone

Summary

Summary: A synthetic hormone with anabolic and androgenic properties.

Top Publications

  1. ncbi Androgen-responsive aspects of cognition in girls with Turner syndrome
    J L Ross
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Endocrinol Metab 88:292-6. 2003
  2. pmc Improved net protein balance, lean mass, and gene expression changes with oxandrolone treatment in the severely burned
    Steven E Wolf
    Department of Surgery, Shriners Burns Hospital, University of Texas Medical Branch, 815 Market, Galveston, TX 77550, USA
    Ann Surg 237:801-10; discussion 810-1. 2003
  3. ncbi Final height in a patient with Laron syndrome after long-term therapy with rhlGF-I and short-term therapy with LHRH-analogue and oxandrolone during puberty
    S Zucchini
    Department of Pediatrics, S Orsola Malpighi Hospital, University of Bologna, Italy
    J Endocrinol Invest 28:274-9. 2005
  4. ncbi Effects of oxandrolone, an anabolic steroid, on hemostasis
    Nighat N Kahn
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Am J Hematol 81:95-100. 2006
  5. pmc The effects of oxandrolone and exercise on muscle mass and function in children with severe burns
    Rene Przkora
    Shriners Hospitals for Children, 815 Market St, Galveston, TX 77550, USA
    Pediatrics 119:e109-16. 2007
  6. pmc SITAR--a useful instrument for growth curve analysis
    Tim J Cole
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK
    Int J Epidemiol 39:1558-66. 2010
  7. pmc Burns: where are we standing with propranolol, oxandrolone, recombinant human growth hormone, and the new incretin analogs?
    Gerd G Gauglitz
    Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany
    Curr Opin Clin Nutr Metab Care 14:176-81. 2011
  8. ncbi Reversal of COPD-associated weight loss using the anabolic agent oxandrolone
    Shing Shing Yeh
    Veterans Affairs Medical Center, Northport, NY, USA
    Chest 122:421-8. 2002
  9. ncbi Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy
    Prabhakaran Balagopal
    Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Am J Physiol Endocrinol Metab 290:E530-9. 2006
  10. ncbi Synthesis, characterization, and detection of new oxandrolone metabolites as long-term markers in sports drug testing
    S Guddat
    Institute of Biochemistry and Center for Preventive Doping Research, German Sport University, Am Sportpark Muengersdorf 6, 50933, Cologne, Germany
    Anal Bioanal Chem 405:8285-94. 2013

Detail Information

Publications140 found, 100 shown here

  1. ncbi Androgen-responsive aspects of cognition in girls with Turner syndrome
    J L Ross
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Endocrinol Metab 88:292-6. 2003
    ..A total of 64 TS girls were randomized to receive oxandrolone or placebo for 2 yr...
  2. pmc Improved net protein balance, lean mass, and gene expression changes with oxandrolone treatment in the severely burned
    Steven E Wolf
    Department of Surgery, Shriners Burns Hospital, University of Texas Medical Branch, 815 Market, Galveston, TX 77550, USA
    Ann Surg 237:801-10; discussion 810-1. 2003
    To determine the effects of the anabolic agent oxandrolone on muscle protein and gene expression in severely burned children.
  3. ncbi Final height in a patient with Laron syndrome after long-term therapy with rhlGF-I and short-term therapy with LHRH-analogue and oxandrolone during puberty
    S Zucchini
    Department of Pediatrics, S Orsola Malpighi Hospital, University of Bologna, Italy
    J Endocrinol Invest 28:274-9. 2005
    ..recombinant-human-IGF-I (rhIGF-I) of a female patient with Laron syndrome (mutation G223G in the GH receptor gene), who received short-term treatment (1 yr) with LHRH analogue at the start of puberty and subsequently with oxandrolone.
  4. ncbi Effects of oxandrolone, an anabolic steroid, on hemostasis
    Nighat N Kahn
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Am J Hematol 81:95-100. 2006
    This study evaluated the short-term effects of oxandrolone, an anabolic androgenic synthetic steroid, on blood coagulation and the hemostatic/fibrinolytic system in healthy individuals...
  5. pmc The effects of oxandrolone and exercise on muscle mass and function in children with severe burns
    Rene Przkora
    Shriners Hospitals for Children, 815 Market St, Galveston, TX 77550, USA
    Pediatrics 119:e109-16. 2007
    Severe burns are associated with a significant loss of muscle and strength. Studies have reported that oxandrolone improves lean body mass in muscle-wasting conditions...
  6. pmc SITAR--a useful instrument for growth curve analysis
    Tim J Cole
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK
    Int J Epidemiol 39:1558-66. 2010
    ..Such data can be summarized with individual Preece-Baines (PB) curves, and their five parameters then related to earlier exposures or later outcomes. But it involves fitting many curves...
  7. pmc Burns: where are we standing with propranolol, oxandrolone, recombinant human growth hormone, and the new incretin analogs?
    Gerd G Gauglitz
    Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany
    Curr Opin Clin Nutr Metab Care 14:176-81. 2011
    ..This review focuses on the more recent advances in therapeutic strategies to attenuate the hypermetabolic response and its associated insulin resistance postburn...
  8. ncbi Reversal of COPD-associated weight loss using the anabolic agent oxandrolone
    Shing Shing Yeh
    Veterans Affairs Medical Center, Northport, NY, USA
    Chest 122:421-8. 2002
    ..Weight restoration has been associated with improved outcomes. The effects of oxandrolone, an adjunct to help restore weight, were evaluated in patients with COPD.
  9. ncbi Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy
    Prabhakaran Balagopal
    Nemours Children s Clinic, Jacksonville, FL 32207, USA
    Am J Physiol Endocrinol Metab 290:E530-9. 2006
    ..Although previous studies have suggested that oxandrolone may be beneficial in DMD, the mechanism of action of oxandrolone on muscle in DMD remains unclear...
  10. ncbi Synthesis, characterization, and detection of new oxandrolone metabolites as long-term markers in sports drug testing
    S Guddat
    Institute of Biochemistry and Center for Preventive Doping Research, German Sport University, Am Sportpark Muengersdorf 6, 50933, Cologne, Germany
    Anal Bioanal Chem 405:8285-94. 2013
    ..For oxandrolone and other 17-methyl steroids, analogs of this metabolite have already been described, but comprehensive ..
  11. ncbi Oxandrolone enhances hepatic ketogenesis in adult men
    Gloria Lena Vega
    Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Investig Med 56:920-4. 2008
    Immediate administration of oxandrolone markedly increases hepatic lipase activity and reduces levels of plasma high-density lipoprotein.
  12. ncbi New oxandrolone derivatives by biotransformation using Rhizopus stolonifer
    M Iqbal Choudhary
    H E J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
    Steroids 74:1040-4. 2009
    Structural transformation of the steroidal lactone, oxandrolone (1), by suspended-cell cultures of the plant pathogen fungus Rhizopus stolonifer, resulted in the production of three new metabolites...
  13. ncbi Treatment with oxandrolone and the durability of effects in older men
    E Todd Schroeder
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    J Appl Physiol 96:1055-62. 2004
    We investigated the effects of the anabolic androgen, oxandrolone, on lean body mass (LBM), muscle size, fat, and maximum voluntary muscle strength, and we determined the durability of effects after treatment was stopped...
  14. ncbi A randomized efficacy and safety trial of oxandrolone in the treatment of Duchenne dystrophy
    G M Fenichel
    Department of Neurology, Ohio State University College of Medicine, USA
    Neurology 56:1075-9. 2001
    A pilot study suggested that oxandrolone, an anabolic steroid, improved strength in boys with Duchenne dystrophy (DD) and indicated the need for a more definitive study.
  15. ncbi Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebo-controlled study
    Carl Grunfeld
    University of California San Francisco, and Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 41:304-14. 2006
    To evaluate the efficacy and safety of oxandrolone in promoting body weight and body cell mass (BCM) gain in HIV-associated weight loss.
  16. pmc Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment
    Rene Przkora
    Department of Surgery, University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA
    Ann Surg 242:384-9, discussion 390-1. 2005
    When given to children for 1 year after a severe burn, oxandrolone significantly improves lean body mass, bone mineral content, and muscle strength...
  17. ncbi The anabolic androgenic steroid oxandrolone in the treatment of wasting and catabolic disorders: review of efficacy and safety
    Rhonda Orr
    School of Exercise and Sport Science, Faculty of Health Sciences, The University of Sydney, Sydney, Australia
    Drugs 64:725-50. 2004
    ..One such agent is the anabolic androgenic steroid (AAS) oxandrolone, which has been used in such clinical situations as HIV-related muscle wasting, severe burn injury, trauma ..
  18. ncbi Favorable final height outcome in girls with Ullrich-Turner syndrome treated with low-dose growth hormone together with oxandrolone despite starting treatment after 10 years of age
    N Stahnke
    University Hospital, Department of Pediatrics, Hamburg, Germany
    J Pediatr Endocrinol Metab 15:129-38. 2002
    The objective of this study was to find out whether moderate doses of growth hormone (GH) in combination with oxandrolone (Ox) and late initiation of puberty could improve adult height even in relatively old patients with Ullrich-Turner ..
  19. ncbi Final height in girls with central idiopathic precocious puberty treated with gonadotropin-releasing hormone analog and oxandrolone
    Alessandra Vottero
    Department of Pediatrics, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    J Clin Endocrinol Metab 91:1284-7. 2006
    ..However, in some patients, the growth deceleration is so marked that the expected improvement in predicted adult height is not achieved...
  20. ncbi Efficacy and safety of oxandrolone in growth hormone-treated girls with turner syndrome
    Leonie A Menke
    Department of Pediatrics, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 95:1151-60. 2010
    GH therapy increases growth and adult height in Turner syndrome (TS). The benefit to risk ratio of adding the weak androgen oxandrolone (Ox) to GH is unclear.
  21. ncbi Final height of patients with Turner's syndrome treated with growth hormone (GH): indications for GH therapy alone at high doses and late estrogen therapy. Italian Study Group for Turner Syndrome
    E Cacciari
    Department of Pediatrics, University of Bologna, Italy
    J Clin Endocrinol Metab 84:4510-5. 1999
    ..30 were treated for >4 yr and 10 for >6 yr); group A2, GH plus ethinyl estradiol (17 patients) or GH plus oxandrolone (10 patients); group B, 51 patients with low doses of GH (0...
  22. ncbi Low sex hormone-binding globulin and testosterone levels in association with erectile dysfunction among human immunodeficiency virus-infected men receiving testosterone and oxandrolone
    Peter Wasserman
    Infectious Disease Division, Department of Medicine New York Hospital Queens, Flushing, NY, USA
    J Sex Med 5:241-7. 2008
    ..acquired immunodeficiency syndrome (AIDS) wasting and hypogonadism are frequently treated with testosterone and oxandrolone, an orally administered anabolic-androgenic steroid hormone...
  23. ncbi The effect of the weak androgen oxandrolone on psychological and behavioral characteristics in growth hormone-treated girls with Turner syndrome
    Leonie A Menke
    Leiden University Medical Center, Department of Pediatrics, Leiden, The Netherlands
    Horm Behav 57:297-305. 2010
    The weak androgen oxandrolone (Ox) increases height gain in growth-hormone (GH) treated girls with Turner syndrome (TS), but may also give rise to virilizing side effects...
  24. pmc The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn
    Marc G Jeschke
    Shriners Hospital for Children, and Department of Surgery, University Texas Medical Branch, Galveston, Texas, USA
    Ann Surg 246:351-60; discussion 360-2. 2007
    Postburn long-term oxandrolone treatment improves hypermetabolism and body composition...
  25. ncbi A pilot randomized trial of oxandrolone in inclusion body myositis
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neurology 58:1081-7. 2002
    Inclusion body myositis (IBM) remains without effective therapy. As anabolic steroids have myotrophic properties, the authors studied whether a synthetic androgen, oxandrolone, would have efficacy in IBM.
  26. ncbi Oxandrolone treatment of childhood hereditary angioedema
    Joseph A Church
    Division of Clinical Immunology and Allergy, Department of Pediatrics, Childrens Hospital Los Angeles and Keck of School of Medicine, The University of Southern California, Los Angeles, California 90027, USA
    Ann Allergy Asthma Immunol 92:377-8. 2004
    ..b>Oxandrolone is a synthetic anabolic steroid with limited virilizing effects that has been used in a variety of pediatric ..
  27. ncbi Oxandrolone treatment in adults with severe thermal injury
    James T Miller
    Department of Pharmacy Services, Sinai Grace Hospital, Detroit, Michigan, USA
    Pharmacotherapy 29:213-26. 2009
    ..b>Oxandrolone, a synthetic derivative of testosterone, has been used in adult patients with severe thermal injury to enhance ..
  28. ncbi Oxandrolone blocks glucocorticoid signaling in an androgen receptor-dependent manner
    Jingbo Zhao
    Rehabilitation and Research Development Center of Excellence for the Medical Consequences of Spinal Cord Injury, VA Medical Center, Bronx, NY, USA
    Steroids 69:357-66. 2004
    The anabolic steroid oxandrolone is increasingly used to preserve or restore muscle mass in those with HIV infection or serious burns. These effects are mediated, in part, by the androgen receptor (AR)...
  29. ncbi Short-term oxandrolone administration stimulates net muscle protein synthesis in young men
    M Sheffield-Moore
    Department of Surgery, University of Texas Medical Branch, and Shriners Burn Hospital for Children, Galveston 77550, USA
    J Clin Endocrinol Metab 84:2705-11. 1999
    ..We investigated whether oxandrolone [Oxandrin (OX)], a synthetic analog of testosterone, would improve net muscle protein synthesis and transport ..
  30. ncbi Body cell mass repletion and improved quality of life in HIV-infected individuals receiving oxandrolone
    Carrie P Earthman
    Department of Nutritional Sciences, The University of Arizona, Tucson, USA
    JPEN J Parenter Enteral Nutr 26:357-65. 2002
    ..study was to measure changes in body cell mass (BCM) and quality of life in HIV-infected individuals undergoing oxandrolone therapy...
  31. ncbi Effects of long-term oxandrolone administration in severely burned children
    Kevin D Murphy
    Department of Surgery, The University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA
    Surgery 136:219-24. 2004
    ..The purpose of this study was to determine whether oxandrolone administration for 1 year after the burn reverses muscle and bone catabolism in hypermetabolic pediatric burn ..
  32. ncbi Comparing megestrol acetate therapy with oxandrolone therapy for HIV-related weight loss: similar results in 2 months
    D Mkaya Mwamburi
    Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Clin Infect Dis 38:895-902. 2004
    ..trial, we compared the effects of 2 months of treatment with either megestrol acetate (800 mg every day) or oxandrolone (10 mg twice per day) on body weight and composition in patients with weight loss of > or =5 kg who were ..
  33. ncbi Hypovitaminosis D in acutely injured pediatric burn patients
    Michele M Gottschlich
    Shriners Hospitals for Children, Cincinnati, OH 45229, USA
    J Am Diet Assoc 104:931-41, quiz 1031. 2004
    ..The prevalence of vitamin D insufficiency, its etiology, and associated sequelae among acutely injured burn patients is unknown...
  34. ncbi Treatment outcome in Turner syndrome
    M Parvin
    Department of Paediatrics, University of Dublin, Trinity College, Tallaght, Dublin 24
    Ir Med J 97:12, 14-5. 2004
    ..age of commencement, cessation, dose and duration of treatment was calculated for growth hormone, oestrogen and oxandrolone, either alone or in combination. Additional factors known to influence growth in TS were also examined...
  35. ncbi Treatment guidelines for HIV-associated wasting
    Bruce Polsky
    Department of Medicine, Division of Infectious Diseases, St Luke s Roosevelt Hospital Center, New York, NY, USA
    HIV Clin Trials 5:50-61. 2004
  36. ncbi The long-term effect of oxandrolone on hepatic acute phase proteins in severely burned children
    Suchmor Thomas
    Department of Surgery, Shriners Hospitals for Children and University of Texas Medical Branch, Galveston, 77550, USA
    J Trauma 56:37-44. 2004
    Acute phase protein production is a hallmark of severe burns. We wondered whether anabolic treatment with oxandrolone would affect these proteins.
  37. ncbi Effects of androgen therapy on adipose tissue and metabolism in older men
    E Todd Schroeder
    Department of Medicine and Division of Infectious Diseases, University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 89:4863-72. 2004
    We investigated the effects of oxandrolone on regional fat compartments and markers of metabolism. Thirty-two 60- to 87-yr-old men (body mass index, 28.1 +/- 3...
  38. ncbi [Therapeutic approach of hereditary angioedema]
    Kélem de Nardi Chagas
    Laboratório de Investigação Médica, Dermatologia e Imunodeficiência, LIM 56, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Rev Assoc Med Bras 50:314-9. 2004
    ..We describe the peculiarities of the treatment chosen for 10 patients (4 families) with HAE and their evolution...
  39. ncbi Influence of hormonal therapy on growth rate and bone age progression in patients with Turner syndrome
    Aneta Gawlik
    Department of Pediatric Endocrinology and Diabetes, Silesian University School of Medicine, Katowice, Poland
    Endokrynol Pol 56:136-44. 2005
    ..type of hormonal therapy: 1) 11 patients treated with growth hormone (GH); 2) 18 patients treated with GH and oxandrolone (Ox); 3) 7 patients treated with GH, Ox and estrogens (E); 4) 6 patients treated with OX and E; and the control ..
  40. ncbi Cost-effectiveness of clinical interventions for AIDS wasting
    A Beaston-Blaakman
    Family Health International, North Carolina 27709, USA
    AIDS Care 19:996-1001. 2007
    ..the costs and impacts of a nutritional counseling intervention alone (NC arm), the nutrition intervention with oxandrolone (OX arm), and the nutrition intervention with progressive resistance training (PRTarm) for the treatment of ..
  41. ncbi The pharmacologic modulation of the hypermetabolic response to burns
    Clifford T Pereira
    Department of Surgery, University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, Texas, USA
    Adv Surg 39:245-61. 2005
    ..low-dose insulin infusion, beta-blockade with propranolol, and the use of the synthetic testosterone analogue oxandrolone are the most cost-effective and least toxic therapies to date...
  42. ncbi Corticosteroid-induced myopathy in spinal cord injury patients: a role for anticatabolic agents?
    R D Dickerman
    Spinal Cord 44:263-4. 2006
  43. pmc Use of oxandrolone in ventilator dependent surgical patients
    C T Pereira
    Ann Surg 241:1030-1; author reply 1031-2. 2005
  44. ncbi [Study of bone mass in Turner syndrome]
    E Cancer Gaspar
    Centro de Salud La Jota, Gobierno de Aragón, Zaragoza Spain
    An Pediatr (Barc) 62:441-9. 2005
    To evaluate bone mass in patients with Turner syndrome by measuring metacarpal cortical thickness and bone diameter before and after treatment with oxandrolone, growth hormone (GH) and estrogens.
  45. ncbi Oxandrolone in pediatric patients with severe thermal burn injury
    James T Miller
    Department of Clinical, Social, and Administrative Sciences, College of Pharmacy, University of Michigan Hospitals and Health Centers, Ann Arbor, MI 48109, USA
    Ann Pharmacother 42:1310-5. 2008
    To review the role of oxandrolone in pediatric patients with severe thermal burn injury.
  46. ncbi Longitudinal monitoring of bone accretion measured by quantitative multi-site ultrasound (QUS) of bones in patients with delayed puberty (a pilot study)
    Zvi Zadik
    The Pediatric Endocrine Unit, Kaplan Medical Center, Hadassah Medical School, 76100 Rehovot, Israel
    Osteoporos Int 16:1036-41. 2005
    ..to compare the effect of anabolic agents on bone accretion in boys with constitutional delay of puberty (CGDP)...
  47. ncbi Incidence of hepatic dysfunction is equivalent in burn patients receiving oxandrolone and controls
    Mona C McCullough
    University ofMiami Miller School ofMedicine, DeWitt Daughtry Family Department of Surgery, Division of Burns, Miami, Florida, USA
    J Burn Care Res 28:412-20. 2007
    b>Oxandrolone has been shown to improve lean muscle mass in patients with burns. Hepatic dysfunction is a known side effect of treatment with oxandrolone...
  48. ncbi Growth and puberty in Turner's syndrome
    Silvano Bertelloni
    Pediatric Endocrinology and Adolescent Medicine, Division of Paediatrics, University of Pisa, Santa Chiara Hospital, Pisa, Italy
    J Pediatr Endocrinol Metab 16:307-15. 2003
    ..Some studies reported that combined therapy with GH and an anabolic steroid--oxandrolone--is also beneficial at lower GH doses...
  49. ncbi Drug increases lean tissue mass in patients with cancer
    Barbara Boughton
    Lancet Oncol 4:135. 2003
  50. ncbi Remission of clinical signs in early duchenne muscular dystrophy on intermittent low-dosage prednisolone therapy
    V Dubowitz
    Dubowitz Neuromuscular Centre, Department of Paediatrics, London, UK
    Eur J Paediatr Neurol 6:153-9. 2002
    ....
  51. ncbi Relationship between body composition and cytokines in cachectic patients with chronic obstructive pulmonary disease
    Shing Shing Yeh
    J Am Geriatr Soc 51:890-1. 2003
  52. ncbi Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies
    E Todd Schroeder
    Division of Infectious Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Am J Physiol Endocrinol Metab 285:E16-24. 2003
    ..Study 2: older healthy men (72 +/- 5 yr) were randomized to oxandrolone (20 mg/day) or placebo...
  53. ncbi AIDS wasting syndrome: trends, influence on opportunistic infections, and survival
    Mark S Dworkin
    Division of HIV AIDS Prevention Surveillance and Epidemiology, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 33:267-73. 2003
    ..Prescription of oxandrolone was associated with improved survival, but the results did not quite reach statistical significance...
  54. ncbi Successful treatment of anabolic steroid-induced azoospermia with human chorionic gonadotropin and human menopausal gonadotropin
    Dev Kumar Menon
    Department of Obstetrics and Gynecology, University Malaya Medical Centre, Kuala Lumpur, Malaysia
    Fertil Steril 79:1659-61. 2003
    ....
  55. pmc Estimation of Cachexia among Cancer Patients Based on Four Definitions
    Kathleen M Fox
    Strategic Healthcare Solutions, LLC, P O Box 543, Monkton, MD 21111, USA
    J Oncol 2009:693458. 2009
    ..of cachexia, anorexia, abnormal weight loss, or feeding difficulties, (3) prescription for megestrol acetate, oxandrolone, somatropin, or dronabinol, and (4) >/=5% weight loss...
  56. ncbi Growth velocity, final height and bone mineral metabolism of short children treated long term with growth hormone
    R Lanes
    Unidad de Endocrinologia Pediatrica, Hospital de Clinicas Caracas, Venezuela
    Curr Pharm Biotechnol 1:33-46. 2000
    ..demonstrated a gain of 8-12 cm in girls with Turner's syndrome treated with GH or with a combination of GH and oxandrolone. Neely et al...
  57. ncbi Orexigenic and anabolic agents
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard M238, Saint Louis, MO 63104, USA
    Clin Geriatr Med 18:853-66. 2002
    ..Anabolic agents, such as oxandrolone, should be reserved for those who have profound cachexia...
  58. ncbi Anabolic steroids, testosterone-precursors and virilizing androgens induce distinct activation profiles of androgen responsive promoter constructs
    P M Holterhus
    Department of Pediatrics, Medical University of Lubeck, Germany
    J Steroid Biochem Mol Biol 82:269-75. 2002
    ..Three virilizing androgens (dihydrotestosterone, testosterone, methyltrienolone), three anabolic steroids (oxandrolone, stanozolol, nandrolone) and two testosterone-precursors of gonadal and adrenal origin (dehydroepiandrosterone, ..
  59. ncbi Anabolic treatment with GH, IGF-I, or anabolic steroids in patients with HIV-associated wasting
    Kathleen Mulligan
    Division of Endocrinology, San Francisco General Hospital and Department of Medicine, University of California, San Francisco, CA 94110, USA
    Int J Cardiol 85:151-9. 2002
    ..anabolic agents, including growth hormone, insulin-like growth factor-I, testosterone, nandrolone decanoate, oxandrolone, and oxymetholone, have been studied in patients with HIV-associated wasting...
  60. ncbi The effects of oestrogens on linear bone growth
    A Juul
    Department of Growth and Reproduction GR, Rigshospitalet, University of Copenhagen, Denmark
    Hum Reprod Update 7:303-13. 2001
    ..androgen receptor (AR) blockade increases GH secretion in peripubertal boys, and non-aromatizable androgens [oxandrolone or dihydrotestosterone (DHT)] have no effect on GH secretion...
  61. ncbi Aspects of the treatment of Turner syndrome
    C H Gravholt
    Medical Department M Endocrinology and Diabetes and Medcal Research Laboratories, Aarhus Kommunehospital, Aarhus University Hospital, Aarhus, Denmark
    Expert Opin Pharmacother 2:1633-47. 2001
    ..concern and treatment with growth hormone (GH) is now widely used, often in conjunction with the androgen, oxandrolone. Recent studies indicate that doses used previously in the treatment of short stature have been too small...
  62. ncbi An update on promising agents for the treatment of cancer cachexia
    Clelia Madeddu
    Department of Medical Oncology, University of Cagliari, Italy
    Curr Opin Support Palliat Care 3:258-62. 2009
    ..The purpose of this review is to supply an update on the promising agents and/or combined approaches for the treatment of cancer cachexia...
  63. ncbi Pelvic ultrasound evaluation in patients with Turner syndrome during treatment with growth hormone
    P Sampaolo
    Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Ultrasound Obstet Gynecol 22:172-7. 2003
    Treatment with growth hormone (GH), alone or in combination with oxandrolone, is used in patients affected by Turner syndrome to improve growth velocity and adult height...
  64. ncbi Corticosteroids in Duchenne muscular dystrophy: a reappraisal
    Brenda L Y Wong
    Division of Child Neurology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Child Neurol 17:183-90. 2002
    ..This is an evidence-based review of all of the studies of corticosteroids (prednisone, deflazacort, and oxandrolone) in Duchenne muscular dystrophy...
  65. ncbi Growth hormone therapy in Turner syndrome--current uncertainties and future strategies
    M D Donaldson
    Department of Child Health, Royal Hospital for Sick Children, Glasgow, Scotland, UK
    Horm Res 48:35-44. 1997
    ..and interpatient variability of response to GH in Turner syndrome, and continuing uncertainty as to the role of oxandrolone and the timing of estrogen therapy, emphasizes the need for further research...
  66. ncbi Improvement in steroid screening for doping control with special emphasis on stanozolol
    Andreas Huenerbein
    LABDOP LADETEC, Instituto de Quimica, Ilha do Fundao, Centro de Tecnologia, Bloco A sala 512, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949 900, RJ, Brazil
    J Chromatogr A 985:375-86. 2003
    ..Later. eluting analytes, such as the stanozolol metabolites, furazabol and oxandrolone were not affected. Temperatures below 140 degrees C...
  67. ncbi Support of the metabolic response to burn injury
    David N Herndon
    Shriners Hospital for Children, 815 Market Street, Galveston, TX 77550, USA
    Lancet 363:1895-902. 2004
    ..of lean body mass to a minimum, administration of anabolic agents, recombinant human growth hormone, insulin, oxandrolone, or anticatabolic drugs such as propranolol are alternative approaches...
  68. ncbi Predicting the response to recombinant human growth hormone in Turner syndrome: KIGS models. KIGS International Board. Kabi International Growth Study
    M B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Acta Paediatr Suppl 88:122-5. 1999
    ..of height velocity in years 1-4 of GH therapy included age (negative), weight SDS and additional treatment with oxandrolone. The predictions in all 4 years were highly accurate, as indicated by the low error SDs...
  69. ncbi Advances in burn care
    Nicholas Namias
    Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Curr Opin Crit Care 13:405-10. 2007
    ..This article reviews and critiques new developments in the critical care of burn patients...
  70. ncbi Turner's syndrome: a paediatric perspective
    T C Sas
    Department of Paediatrics, Division of Endocrinology, Sophia Children s Hospital University Hospital, Dr Molewaterplein 40, NL 3015 GL Rotterdam, The Netherlands
    Horm Res 56:38-43. 2001
    ..045 mg/kg per day). Higher GH doses (6 or 8 IU/m(2) per day) or the use of oxandrolone may be more effective, but their efficacy on adult height and safety in the very long term still have to be ..
  71. ncbi A double-blind, placebo-controlled comparison of letrozole to oxandrolone effects upon growth and puberty of children with constitutional delay of puberty and idiopathic short stature
    Shadab Salehpour
    Mofid Children s Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran shadab salehpour gmail com
    Horm Res Paediatr 74:428-35. 2010
    ..We compared the effects of letrozole with that of oxandrolone on predicted adult height (PAH), puberty, bone mineral density, serum insulin-like growth factor 1 (IGF-1) and ..
  72. ncbi Nutritional and pharmacological support of the metabolic response to injury
    D N Herndon
    Shriners Hospitals for Children Galveston Burns Hospital, SHC G, Professor of Pediatrics and Surgery, University of Texas Medical Branch, UTMB, USA
    Minerva Anestesiol 69:264-74. 2003
    ..To further minimize erosion of lean body mass administration of recombinant human growth hormone, insulin, oxandrolone or propranolol are all reasonable approaches...
  73. ncbi Long-term treatment with growth hormone has no persisting effect on lipoprotein(a) in patients with Turner's syndrome
    U Querfeld
    Department of Pediatrics, University of Cologne, Germany
    J Clin Endocrinol Metab 84:967-70. 1999
    Treatment with recombinant human GH (rhGH), alone or in combination with the anabolic steroid oxandrolone (OX), has been recommended for girls with Turner's syndrome to improve final height...
  74. ncbi Duchenne muscular dystrophy: Drug development and regulatory considerations
    D Elizabeth McNeil
    FDA Office of Orphan Product Development OOPD, 5600 Fishers Lane HF 35, Food and Drug Administration FDA, US Department of Health and Human Services, Rockville, Maryland 20857, USA
    Muscle Nerve 41:740-5. 2010
    ..g., cardiac and respiratory dysfunction related to reduced or absent dystrophin production? It seems reasonable to argue that clinical trials planned for DMD should consider the entire population...
  75. ncbi Treatment of children and adolescents with idiopathic short stature
    Michael B Ranke
    University Children s Hospital Tubingen, Hoppe Seyler Strasse 1, D 72076 Tubingen, Germany
    Nat Rev Endocrinol 9:325-34. 2013
    ..In cases with pubertal delay, sex steroids, such as testosterone and oxandrolone, can favourably influence height velocity and growth tempo, although adult height is not affected...
  76. ncbi Nutritional supplements cross-contaminated and faked with doping substances
    Hans Geyer
    Center for Preventive Doping Research, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany
    J Mass Spectrom 43:892-902. 2008
    ..of 'classic' anabolic steroids such as metandienone, stanozolol, boldenone, dehydrochloromethyl-testosterone, oxandrolone etc. have been detected on the nutritional supplement market...
  77. pmc Burns: an update on current pharmacotherapy
    Yesenia Rojas
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Expert Opin Pharmacother 13:2485-94. 2012
    ..Incorporation of pharmacotherapeutics into treatment regimens may further reduce complications of severe burn injuries...
  78. ncbi Emerging medication for the treatment of male hypogonadism
    Giovanni Corona
    University of Florence, Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, Florence, Italy
    Expert Opin Emerg Drugs 17:239-59. 2012
    ..Since the phenotype and clinical need of the hypogonadal individuals changes dramatically over time, versatile therapies are needed...
  79. pmc Five-year outcomes after oxandrolone administration in severely burned children: a randomized clinical trial of safety and efficacy
    Laura J Porro
    Shriners Hospitals for Children Galveston, Galveston, TX 77550, USA
    J Am Coll Surg 214:489-502; discussion 502-4. 2012
    b>Oxandrolone, an anabolic agent, has been administered for 1 year post burn with beneficial effects in pediatric patients. However, the long-lasting effects of this treatment have not been studied...
  80. ncbi Presence of endogenous interferences in the urinary detection of selected anabolic steroids by liquid chromatography/electrospray tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 21:2785-96. 2007
    ..This has been shown for 1-testosterone, 5beta-androst-1-ene-17beta-ol-3-one and oxandrolone where the selection of the uncommon [M+H+MeOH](+) as the precursor ion increased the selectivity of the method...
  81. ncbi Protein-energy malnutrition and involuntary weight loss: nutritional and pharmacological strategies to enhance wound healing
    Nancy Collins
    Nutrition Guidance Center, 18459 Pines Blvd, Suite 204, Pembroke Pines, FL 33029 1422, USA
    Expert Opin Pharmacother 4:1121-40. 2003
    ..therapy that provides adequate protein, calories and micronutrients, combined with an anabolic agent such as oxandrolone, may provide the most optimal environment for restoration of lean body mass and body weight and in turn, ..
  82. ncbi Hormonal therapy in a patient with a delayed diagnosis of Turner's syndrome
    Aneta Gawlik
    Department of Pediatric Endocrinology and Diabetes of the Medical University of Silesia, Katowice, Poland
    Nat Clin Pract Endocrinol Metab 4:173-7. 2008
    ..A number of typical features of Turner's syndrome were found, including a short webbed neck, cubitus valgus, shield chest, multiple pigmented nevi, lymphedema, epicanthus and micrognathia...
  83. ncbi Studies on anabolic steroids--12. Epimerization and degradation of anabolic 17 beta-sulfate-17 alpha-methyl steroids in human: qualitative and quantitative GC/MS analysis
    H Bi
    Institut National de la Recherche Scientifique, INRS Santé, Universite du Quebec, Canada
    J Steroid Biochem Mol Biol 42:533-46. 1992
    ..using the pyridinium salts of 17 beta-sulfate derivatives of methandienone 1, methyltestosterone 4, oxandrolone 7, mestanolone 10 and stanozolol 11 as model compounds...
  84. ncbi Cancer-induced cachexia: a guide for the oncologist
    Norleena Gullett
    Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA
    J Soc Integr Oncol 7:155-69. 2009
    ..Experimental therapies are also discussed, including nonsteroidal antiinflammatory drugs, tumor necrosis factor alpha antagonists, tetrahydrocannabinol, growth hormone, ghrelin, oxandrolone, and omega-3 fatty acids.
  85. ncbi Oxandrolone steroid use and impaired coagulation
    Elizabeth A Koller
    Arch Intern Med 166:125. 2006
  86. ncbi [Carbohydrate metabolism in patients with Turner syndrome. The effect of therapy with growth hormone, oxandrolone and a combination of both]
    Jerzy Starzyk
    Klinika Endokrynologii Dieci i Młodziezy Katedry Pediatrii, Collegium Medicum UJ w Krakowie, Krakow
    Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw 11:79-84. 2005
    ..and IV glucose tolerance test in patients with Turner syndrome after a 6-month therapy with growth hormone, oxandrolone (Ox) and a combination of these two agents (hGH+Ox)...
  87. ncbi Turner syndrome in childhood and adolescence
    Jennifer Batch
    Royal Children s Hospital, Herston, Brisbane, Queensland 4029, Australia
    Best Pract Res Clin Endocrinol Metab 16:465-82. 2002
    ..Growth hormone (GH) given alone or with oxandrolone improves final height...
  88. ncbi Androgen therapy in constitutional delay of growth
    Meir Lampit
    Meyer Children s Hospital, Rambam Medical Center, Haifa, Israel
    Horm Res 59:270-5. 2003
    ..prevail in the treatment of constitutional delay of growth (CDG): monthly injections of testosterone or daily tablets of the non-aromatizable oxandrolone. The present study was undertaken to prospectively compare both compounds and dose.
  89. ncbi Screening of free 17-alkyl-substituted anabolic steroids in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry
    Antti Leinonen
    Doping Control Laboratory, United Laboratories Ltd, Helsinki, Finland
    Steroids 69:101-9. 2004
    ..of the abuse of 4-chlorodehydromethyltestosterone, danazol, fluoxymesterone, formebolone, metandienone, oxandrolone, and stanozolol...
  90. ncbi Influence of X chromosome and hormones on human brain development: a magnetic resonance imaging and proton magnetic resonance spectroscopy study of Turner syndrome
    William J Cutter
    Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Biol Psychiatry 59:273-83. 2006
    ..Hence, they allow us an opportunity to investigate genetic and endocrine influences on brain development...
  91. ncbi The right mix: using nutritional interventions and an anabolic agent to manage a stage IV ulcer
    Nancy Collins
    Adv Skin Wound Care 17:36, 38-9. 2004
  92. ncbi Altering metabolism
    Clifford T Pereira
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    J Burn Care Rehabil 26:194-9. 2005
    ..of recombinant human growth hormone, low-dose insulin infusion, use of the synthetic testosterone analog, oxandrolone, and beta blockade with propranolol. This review article discusses these modulators of postburn metabolism.
  93. ncbi Longitudinal monitoring of bone measured by quantitative multisite ultrasound in patients with Crohn's disease
    Zvi Zadik
    Pediatric Endocrine Unit, Kaplan Medical Center, Hadassah Medical School, Jerusalem, Israel
    J Clin Gastroenterol 39:120-3. 2005
    ..This may cause a suboptimal peak bone mass and thereby susceptibility to osteoporosis at an early age...
  94. pmc Oxandrolone does not improve outcome of ventilator dependent surgical patients
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle 98104, USA
    Ann Surg 240:472-8; discussion 478-80. 2004
    ..b>Oxandrolone is an anabolic steroid that attenuates loss of lean body mass and improves wound healing in burn patients...
  95. ncbi Screening of anabolic steroids in horse urine by liquid chromatography-tandem mass spectrometry
    Nola H Yu
    Racing Laboratory, The Hong Kong Jockey Club, Sha Tin Racecourse, Sha Tin, N T, Hong Kong, PR China
    J Pharm Biomed Anal 37:1031-8. 2005
    ..gestrinone, methandrostenolone, methenolone, 17alpha-methyltestosterone, norbolethone, normethandrolone, oxandrolone, stenbolone, trenbolone and turinabol) at low ng/mL levels were consistently detected...
  96. ncbi Recombinant human growth hormone for treating burns and donor sites
    Roelf S Breederveld
    Surgery and Burn Centre, Red Cross Hospital, Beverwijk, Netherlands
    Cochrane Database Syst Rev 12:CD008990. 2012
    ..This change in protein metabolism correlates with poor wound healing of the burn and donor sites...
  97. ncbi Alcoholic hepatitis: a clinician's guide
    Gina Choi
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90043, USA
    Clin Liver Dis 16:371-85. 2012
    ..Typically patients have a background of drinking on a daily basis, but, in response to a life crisis, patients have started drinking massively...
  98. ncbi Update on treatment of inclusion body myositis
    Maren Breithaupt
    Department of Neurology, University Medical Centre Göttingen, Robert Koch Str 40, 37075, Gottingen, Germany
    Curr Rheumatol Rep 15:329. 2013
    ..Different treatment studies with drugs that aim at degenerative disease mechanisms are planned or ongoing. This review aims to provide an overview of the current treatment options for IBM...
  99. pmc The effect of oxandrolone treatment on human osteoblastic cells
    Lian Xiang Bi
    Department of Oral and Maxillofacial Surgery, University of Texas Medical Branch, Galveston, TX, USA
    J Burns Wounds 6:e4. 2007
    b>Oxandrolone, administered to severely burned children over the first year postburn, produces increased lean body mass by 6 months; however, an increase in total body bone mineral requires 12 months...
  100. ncbi Growth hormone therapy in Turner syndrome
    Marsha L Davenport
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7032, USA
    Pediatr Endocrinol Rev 9:723-4. 2012
    ..Recently, randomized, controlled studies have demonstrated that adjunctive therapies with low-dose estrogen or low-dose oxandrolone enhance stature further. These therapies may provide benefits beyond height augmentation.
  101. pmc Oxandrolone Improves Height Velocity and BMI in Patients with Cystic Fibrosis
    Todd Varness
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, H4 4 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792 4108, USA
    Int J Pediatr Endocrinol 2009:826895. 2009
    Objective. To evaluate the effectiveness of oxandrolone in improving the nutritional status and linear growth of pediatric patients with cystic fibrosis (CF). Methods...

Research Grants20

  1. Novel treatment for muscle disease: Fueling the pipeline and finding the product
    ROBERT GRIGGS; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  2. Pediatric Heart Network University of Utah
    RICHARD VINCENT WILLIAMS; Fiscal Year: 2013
    ..b>Oxandrolone is an anabolic steroid that has been in routine clinical use for over 30 years...
  3. ANABOLIC HORMONES IN NUTRITION SUPPORT
    Thomas Ziegler; Fiscal Year: 1999
    ..anabolic growth factors (including growth hormone and IGF-1) and anabolic steroids (including testosterone and oxandrolone) as agents to improve lean body mass, muscle function, wound healing and other important clinical endpoints...
  4. Physiological Adaptations to Exercise in Burned Children
    Oscar Suman; Fiscal Year: 2006
    ..Specific Aim 3 will assess whether administration of an anabolic agent (oxandrolone) to burned children will further enhance the effects of exercise on CV and skeletal muscle functional capacity...
  5. OXANDROLONE FOR THE TREATMENT OF MARROW APLASIA IN FANC*
    FRANKLIN SMITH; Fiscal Year: 2007
    ..Abstract Not Provided ..
  6. Muscle Perfusion and Protein Metabolism in Elderly
    Melinda Sheffield Moore; Fiscal Year: 2009
    ..Results from these studies will provide evidence as to the regulatory role of increased muscle perfusion, amino acid supplementation and aerobic exercise as means of improving skeletal muscle protein synthesis in the elderly. ..
  7. ANDROGEN EFFECTS ON COGNITION IN TURNER SYNDROME
    Judith Ross; Fiscal Year: 2007
    ..In addition, these data will help determine how to optimize cognitive function in Turner syndrome and will extend knowledge of the mechanisms of male/female cognitive dimorphisms. ..
  8. Androgen effect on motor/cognitive outcome in Klinefelter syndrome
    Judith L Ross; Fiscal Year: 2010
    ..The Phase I study will establish that the androgen oxandrolone, an FDA-approved medication for children, is also safe in prepubertal KS boys...
  9. GENETICS OF COGNITION IN ADULT TURNER SYNDROME
    Judith Ross; Fiscal Year: 2005
    ..Characterization of specific TS causative genes would provide insight into the pathophysiology of 45,X, Turner syndrome, as well as the process of normal neurocognitive development. ..
  10. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..
  11. Dichlorphenamide vs Acetazolamide for Periodic Paralysis
    Robert C Griggs; Fiscal Year: 2010
    ..abstract_text> ..
  12. Experimental Therapeutics of Neuromuscular Disease
    ROBERT GRIGGS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  13. Novel Designs and Outcome Measures for Bench to Bedside Research on NMD
    ROBERT GRIGGS; Fiscal Year: 2007
    ..In this effort to provide new treatments for neuromuscular disease, this conference will help to further public health goals. [unreadable] [unreadable] [unreadable]..
  14. Yoga for the Management of HIV-Metabolic Syndromes
    Kevin Yarasheski; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  15. METABOLIC EFFECTS OF PROTEASE INHIBITORS IN HIV DISEASE
    Kathleen Mulligan; Fiscal Year: 2002
    ....
  16. Characterizing the HIV-Muscle Mitochondrial Proteme
    Kevin Yarasheski; Fiscal Year: 2006
    ..To accomplish this, we will take advantage of the expertise and the wide variety of high resolution mass spectrometry instrumentation available at Washington University. ..
  17. Plan forTrial to find Optimum Steroid Regimen in Duchenne Muscular Dystrophy
    ROBERT GRIGGS; Fiscal Year: 2006
    ....
  18. Nervous System Channelopathies: Pathogenesis & Treatment
    ROBERT GRIGGS; Fiscal Year: 2005
    ..They may also offer a window for understanding common disorders likely to be caused by CNS channel mutations/dysfunction such as migraine and epilepsy. ..
  19. Pathogenesis and treatment of the periodic paralyses
    ROBERT GRIGGS; Fiscal Year: 2004
    ....
  20. The Effect of Hypertonic Resuscitation for Blunt Trauma
    Eileen Bulger; Fiscal Year: 2005
    ..abstract_text> ..