steroids

Summary

Summary: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)

Top Publications

  1. ncbi Polyoxygenated steroids from the gorgonian Isis hippuris
    Chih Hua Chao
    Department of Marine Resources, National Sun Yat Sen University, Taiwan, Republic of China
    J Nat Prod 68:880-5. 2005
  2. pmc Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors
    Brandon M Stell
    Department of Neurology, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:14439-44. 2003
  3. ncbi One-year results of a randomized, double-blind, active controlled trial of fluoroscopic caudal epidural injections with or without steroids in managing chronic discogenic low back pain without disc herniation or radiculitis
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 14:25-36. 2011
  4. ncbi The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression
    Qun Pan
    Department of Obstetrics Gynecology, University of Florida, Box 100294, Gainesville, FL 32610, USA
    Mol Hum Reprod 13:797-806. 2007
  5. ncbi The efficacy of transforaminal injection of steroids for the treatment of lumbar radicular pain
    Ali Ghahreman
    Department of Neurosurgery, John Hunter Hospital, NSW, Australia
    Pain Med 11:1149-68. 2010
  6. pmc Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice
    R M Mihalek
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 96:12905-10. 1999
  7. ncbi Effects of androgenic-anabolic steroids in athletes
    Fred Hartgens
    Department of Surgery, Outpatient Clinic Sports Medicine, University Hospital Maastricht, and Sports Medicine Center Maastricht, Maastricht, The Netherlands
    Sports Med 34:513-54. 2004
  8. pmc Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids
    Qun Pan
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL 32610, USA
    J Cell Mol Med 12:227-40. 2008
  9. ncbi Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells
    Wenxiang Luo
    Endocrinology Reproductive Physiology Program and Department of Dairy Science, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biol Reprod 75:217-25. 2006
  10. ncbi Changes in the miRNA profile under the influence of anabolic steroids in bovine liver
    Christiane Becker
    Physiology Weihenstephan, Technische Universitaet Muenchen, Weihenstephaner Berg 3, 85384 Freising, Germany
    Analyst 136:1204-9. 2011

Detail Information

Publications363 found, 100 shown here

  1. ncbi Polyoxygenated steroids from the gorgonian Isis hippuris
    Chih Hua Chao
    Department of Marine Resources, National Sun Yat Sen University, Taiwan, Republic of China
    J Nat Prod 68:880-5. 2005
    ..Single-crystal X-ray diffraction analyses supported the structure elucidation of known steroids 5 and 10...
  2. pmc Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors
    Brandon M Stell
    Department of Neurology, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:14439-44. 2003
    Neuroactive steroids are potent modulators of gamma-aminobutyric acid type A receptors (GABAARs), and their behavioral effects are generally viewed in terms of altered inhibitory synaptic transmission...
  3. ncbi One-year results of a randomized, double-blind, active controlled trial of fluoroscopic caudal epidural injections with or without steroids in managing chronic discogenic low back pain without disc herniation or radiculitis
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 14:25-36. 2011
    ..However, there is little evidence utilizing contemporary methodology for using epidural injections in patients with discogenic pain...
  4. ncbi The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression
    Qun Pan
    Department of Obstetrics Gynecology, University of Florida, Box 100294, Gainesville, FL 32610, USA
    Mol Hum Reprod 13:797-806. 2007
    ..up the possibility that aberrant/altered expression of some miRNAs whose expression is regulated by the ovarian steroids may influence the expression of specific target genes with central roles in normal endometrial cellular ..
  5. ncbi The efficacy of transforaminal injection of steroids for the treatment of lumbar radicular pain
    Ali Ghahreman
    Department of Neurosurgery, John Hunter Hospital, NSW, Australia
    Pain Med 11:1149-68. 2010
    Transforaminal injection of steroids is used to treat lumbar radicular pain. Not known is whether the route of injection or the agent injected is significant.
  6. pmc Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice
    R M Mihalek
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 96:12905-10. 1999
    ..synaptic transmission and have been implicated in responses to sedative/hypnotic agents (including neuroactive steroids), anxiety, and learning and memory...
  7. ncbi Effects of androgenic-anabolic steroids in athletes
    Fred Hartgens
    Department of Surgery, Outpatient Clinic Sports Medicine, University Hospital Maastricht, and Sports Medicine Center Maastricht, Maastricht, The Netherlands
    Sports Med 34:513-54. 2004
    Androgenic-anabolic steroids (AAS) are synthetic derivatives of the male hormone testosterone. They can exert strong effects on the human body that may be beneficial for athletic performance...
  8. pmc Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids
    Qun Pan
    Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL 32610, USA
    J Cell Mol Med 12:227-40. 2008
    ..with their progressive aberrant from normal MSMC into LSMC, transformed and cancerous stage, suggests that miRNAs and their regulation by ovarian steroids play a key role in pathogenesis of leiomyoma through gene expression stability.
  9. ncbi Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells
    Wenxiang Luo
    Endocrinology Reproductive Physiology Program and Department of Dairy Science, University of Wisconsin, Madison, Wisconsin 53706, USA
    Biol Reprod 75:217-25. 2006
    ..These inter- and intracellular regulatory mechanisms may be critical for normal follicle growth and dominant follicle selection...
  10. ncbi Changes in the miRNA profile under the influence of anabolic steroids in bovine liver
    Christiane Becker
    Physiology Weihenstephan, Technische Universitaet Muenchen, Weihenstephaner Berg 3, 85384 Freising, Germany
    Analyst 136:1204-9. 2011
    ..Thus, the influence of anabolic steroids on miRNA expression in bovine liver should be investigated and an expression pattern should be validated, which ..
  11. ncbi Mixture of new sulfated steroids functions as a migratory pheromone in the sea lamprey
    Peter W Sorensen
    Department of Fisheries, Wildlife and Conservation Biology, University of Minnesota, St Paul, Minnesota 55108, USA
    Nat Chem Biol 1:324-8. 2005
    ..This mixture is the first migratory pheromone identified in a vertebrate and is being investigated for use in lamprey control...
  12. ncbi Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids
    Satoshi Endo
    Laboratory of Biochemistry, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Arch Biochem Biophys 487:1-9. 2009
    ..03-25 microM. Kinetic analyses of the alcohol oxidation and inhibition by the steroids and tolrestat, together with the docked model of AKR1B10-inhibitor complex, suggest that the inhibitory steroids ..
  13. pmc MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets
    Shaolei Lu
    Department of Pathology and Laboratory Medicine, Rhode Island Hospital, The Alpert School of Medicine, Brown University, Providence, Rhode Island, United States of America
    PLoS ONE 7:e40676. 2012
    ..Here we present novel findings defining the miRNA and mRNA transcriptome in eosinophilic esophagitis (EoE), an increasing recognized allergic disorder...
  14. pmc Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis
    Lisa Hartling
    Alberta Research Centre for Health Evidence, Department of Pediatrics, University of Alberta, 11402 University Avenue, Edmonton, AB, Canada T6G 2J3
    BMJ 342:d1714. 2011
    To evaluate and compare the efficacy and safety of bronchodilators and steroids, alone or combined, for the acute management of bronchiolitis in children aged less than 2 years.
  15. ncbi Cytotoxic steroids from Polyporus umbellatus
    Ying Yong Zhao
    Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi an, China
    Planta Med 76:1755-8. 2010
    The steroids ergone (1), (22E, 24R)-ergosta-7,22-dien-3β-ol (2), 5α,8α-epidioxy-(22E,24R) -ergosta-6,22-dien-3β-ol (3), ergosta-6,22-dien-3β,5α,6β-triol (4), and polyporusterone B (5) were isolated from Polyporus umbellatus by ..
  16. ncbi Do mollusks use vertebrate sex steroids as reproductive hormones? II. Critical review of the evidence that steroids have biological effects
    Alexander P Scott
    Centre for Environment, Fisheries and Aquaculture Science, Weymouth, Dorset, UK
    Steroids 78:268-81. 2013
    In assessing the evidence as to whether vertebrate sex steroids (e.g. testosterone, estradiol, progesterone) have hormonal actions in mollusks, ca...
  17. ncbi Low-dose steroids in adult septic shock: results of the Surviving Sepsis Campaign
    Brian Casserly
    University of Limerick, Graduate Entry Medical School, Limerick, Ireland
    Intensive Care Med 38:1946-54. 2012
    The Surviving Sepsis Campaign (SSC) developed guidelines and treatment bundles for the administration of steroids in adult septic shock. However, it is not clear how this has affected clinical practice or patient outcome.
  18. ncbi Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial
    David Laharie
    CHU de Bordeaux, Hopital Haut Leveque, Service d Hepato Gastroenterologie, Bordeaux, France
    Lancet 380:1909-15. 2012
    ..We compared the efficacy and safety of these drugs for this indication...
  19. ncbi Endocrine regulation of cervical ripening in humans--potential roles for gonadal steroids and insulin-like growth factor-I
    Gunvor Ekman-Ordeberg
    Department of Woman and Child Health, Divisions for Obstetrics and Gynecology, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    Steroids 68:837-47. 2003
    ..Oral administration of RU486 induced a significant increase in ER protein concentration, whereas PGE2 and spontaneous ripening did not. These findings indicate that cervical ripening is related to significant local hormonal changes...
  20. ncbi A bibliometric analysis of European versus USA research in the field of addiction. Research on alcohol, narcotics, prescription drug abuse, tobacco and steroids 2001-2011
    Jørgen G Bramness
    Norwegian Centre for Addiction Research, University of Oslo, Oslo, Norway
    Eur Addict Res 20:16-22. 2014
    ..To compare the publication and citation rate within the areas of drug abuse and dependence research in Europe with that in the USA...
  21. ncbi Hirsutosterols A-G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta
    Bo Wei Chen
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung, 804, Taiwan
    Org Biomol Chem 9:3272-8. 2011
    Seven new polyoxygenated steroids, hirsutosterols A-G (1-7), were isolated from the Formosan soft coral Cladiella hirsuta. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments...
  22. ncbi Simultaneous determination of eight major steroids from Polyporus umbellatus by high-performance liquid chromatography coupled with mass spectrometry detections
    Ying Yong Zhao
    Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai North Road, Xi an, Shaanxi, 710069, China
    Biomed Chromatogr 24:222-30. 2010
    ..spectrometric detection (HPLC-APCI-MS) method was developed for qualitative and quantitative analysis of steroids, as well as for the quality control of Polyporus umbellatus...
  23. ncbi Down-regulation of genes encoding steroidogenic enzymes and hormone receptors in late preovulatory follicles of the cow coincides with an accumulation of intrafollicular steroids
    Marika Nimz
    Forschungsbereich Molekularbiologie, Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere, Wilhelm Stahl Allee 2, Dummerstorf, Germany
    Domest Anim Endocrinol 37:45-54. 2009
    ..Collectively, our data show that late preovulatory follicles have a transient and unique gene expression profile and are clearly different from both the preceding and subsequent (follicular and luteal, respectively) stages...
  24. ncbi Interlaminar versus transforaminal epidural steroids for the treatment of subacute lumbar radicular pain: a randomized, blinded, prospective outcome study
    Christopher G Gharibo
    NYU Langone Hospital for Joint Diseases, NYU School of Medicine, New York, NY 10003, USA
    Pain Physician 14:499-511. 2011
    ..Most studies to date have been retrospective, or technically focused...
  25. ncbi New 19-oxygenated and 4-methylated steroids from the Formosan soft coral Nephthea chabroli
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung, Taiwan
    Steroids 74:543-7. 2009
    ..investigation of the Formosan soft coral Nephthea chabroli resulted in the isolation of four new 19-oxygenated steroids, nebrosteroids I-L (1-4), together with a new 4alpha-methylated steroid, nebrosteroid M (5)...
  26. ncbi Neuroactive steroids: focus on human brain
    R C Melcangi
    Department of Endocrinology, Pathophysiology and Applied Biology Center of Excellence on Neurodegenerative Diseases, Universita degli Studi di Milano, Via Balzaretti 9, 20133, Milano, Italy
    Neuroscience 191:1-5. 2011
    Studies in experimental animals have revealed important roles of neuroactive steroids in the control of central nervous system functions during physiological and pathological conditions, suggesting that they may represent good candidates ..
  27. pmc Decreased response to inhaled steroids in overweight and obese asthmatic children
    Erick Forno
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    J Allergy Clin Immunol 127:741-9. 2011
    ..The mechanisms and consequences of the observed association between obesity and childhood asthma are unclear...
  28. ncbi Candida in oral lichen planus patients undergoing topical steroid therapy
    Aree Jainkittivong
    Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:61-6. 2007
    ..To determine the incidence, intensity, and species of Candida in the oral cavity of oral lichen planus (OLP) patients who were being treated with a topical steroid...
  29. ncbi Interplay between endocannabinoids, steroids and cytokines in the control of human reproduction
    N Battista
    Department of Biomedical Sciences, University of Teramo, Teramo, Italy
    J Neuroendocrinol 20:82-9. 2008
    ..In addition, we shall discuss the interplay between ECS, sex hormones and cytokines, which generates an endocannabinoid-hormone-cytokine array critically involved in the control of human reproduction...
  30. ncbi Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans
    Dhaval S Patel
    Department of Biological Structure, University of Washington, Seattle, WA, USA
    Development 135:2239-49. 2008
    ..Finally, we found that the HSD-1-mediated signal activates insulin/IGF-I signaling in a cell non-autonomous fashion, suggesting a novel mechanism for how these two endocrine pathways intersect in directing development...
  31. ncbi Neuroprotective actions of sex steroids in Parkinson's disease
    Mélanie Bourque
    Molecular Endocrinology and Genomic Research Center, Laval University Medical Center, CHUL, Quebec City, Quebec, Canada
    Front Neuroendocrinol 30:142-57. 2009
    ..The sex difference in Parkinson's disease, with a higher susceptibility in men, suggests a modulatory effect of sex steroids in the brain...
  32. ncbi Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems
    T P Su
    Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224
    Science 240:219-21. 1988
    ..In this study, certain gonadal and adrenal steroids, particularly progesterone, were found to inhibit sigma receptor binding in homogenates of brain and spleen...
  33. ncbi Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated inflammation
    I R Mackenzie
    Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, Vancouver, BC, Canada
    Neurobiol Aging 22:819-22. 2001
    ..The results of these and future postmortem studies will be invaluable in the development of optimum treatment strategies...
  34. pmc SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4
    Hannah Mandel
    Metabolic Disease Unit, Meyer Children s Hospital, Haifa 31096, Israel
    Am J Hum Genet 82:39-47. 2008
    ..Taken together with previous observations in animal models, the present data attribute a pivotal role to WNT4 signaling during organogenesis in humans...
  35. ncbi Leydig cell steroidogenesis: unmasking the functional importance of mitochondria
    Syed G Haider
    Institute of Anatomy II, Heinrich Heine University, Mooren Strasse 5, D 40225 Duesseldorf, Germany
    Endocrinology 148:2581-2. 2007
  36. ncbi ABCG2 transports sulfated conjugates of steroids and xenobiotics
    Michiko Suzuki
    School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 278:22644-9. 2003
    ..It was suggested that ABCG2 preferentially transports sulfate conjugates and that E1S and DHEAS are the potential physiological substrates for this transporter...
  37. ncbi Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats
    Julie Boberg
    National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Toxicology 250:75-81. 2008
    ..This study reveals new targets for phthalates and parabens in fetal male and female rats and contributes to the increasing concern about adverse effects of human exposure to these compounds...
  38. ncbi A prospective randomized trial comparing tacrolimus and steroids with tacrolimus monotherapy in liver transplantation: the impact on recurrence of hepatitis C
    Carlos Margarit
    Liver Transplantation Unit, Department of General Surgery, Hospital Vall Hebron, Universidad Autonoma Barcelona, Barcelona, Spain
    Transpl Int 18:1336-45. 2005
    ..and safety of tacrolimus monotherapy (TACRO) and compare it with our standard treatment of tacrolimus plus steroids (TACRO + ST) after liver transplant (LT)...
  39. pmc Sex steroids and stem cell function
    Rinki Ray
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Mol Med 14:493-501. 2008
    ..The beneficial effects of sex steroids include alteration of lipid metabolism in preadipocytes, modulation of bone metabolism and skeletal maturation, ..
  40. pmc Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS)
    Nils Krone
    Centre for Endocrinology, Diabetes and Metabolism, School for Clinical and Experimental Medicine, University of Birmingham, United Kingdom
    J Steroid Biochem Mol Biol 121:496-504. 2010
    ..While this approach is the gold-standard for measurement of individual steroids, and panels of such compounds, LC/MS/MS is of limited use in defining novel metabolomes...
  41. pmc A new bacterial steroid degradation gene cluster in Comamonas testosteroni TA441 which consists of aromatic-compound degradation genes for seco-steroids and 3-ketosteroid dehydrogenase genes
    Masae Horinouchi
    RIKEN JST, Wako Shi, Saitama 351 0198, Japan
    Appl Environ Microbiol 69:4421-30. 2003
    ..By Northern blot analysis, these genes were shown to be induced when TA441 was incubated with steroids (testosterone and cholic acid) but not with aromatic compounds [phenol, biphenyl, and 3-(3-hydroxyphenyl)..
  42. ncbi Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain
    M Serra
    Department of Experimental Biology, University of Cagliari, Cagliari, Italy
    J Neurochem 75:732-40. 2000
    ..Acute footshock stress induced greater percentage increases in the cortical concentrations of neuroactive steroids in isolated rats than in group-housed rats...
  43. ncbi The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence
    A L Morrow
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res Brain Res Rev 37:98-109. 2001
    ..The identification of neurosteroid intermediaries involved in ethanol action may lead to important advances in the field and the development of novel therapeutics for alcoholism...
  44. ncbi Measuring fecal steroids: guidelines for practical application
    Rupert Palme
    Institute of Biochemistry, Department of Natural Sciences, University of Veterinary Medicine, Veterinaerplatz 1, A 1210 Vienna, Austria
    Ann N Y Acad Sci 1046:75-80. 2005
    ..These issues are discussed briefly here and in more detail in other recent articles...
  45. ncbi Cardiovascular management of septic shock
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper Health System, Camden 08103, USA
    Crit Care Med 31:946-55. 2003
  46. ncbi Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis
    Jun Liu
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 281:38879-93. 2006
    ....
  47. pmc Sulfated steroids as natural ligands of mouse pheromone-sensing neurons
    Francesco Nodari
    Department of Anatomy and Neurobiology, School of Medicine, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Neurosci 28:6407-18. 2008
    ..Purification and structural analysis of active compounds revealed multiple sulfated steroids, of which two were identified as sulfated glucocorticoids, including corticosterone 21-sulfate...
  48. ncbi Advantages and challenges of mass spectrometry assays for steroid hormones
    Frank Z Stanczyk
    Departments of Obstetrics and Gynecology, and Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    J Steroid Biochem Mol Biol 121:491-5. 2010
    ..The present review discusses the advantages of MS assays over conventional RIAs and direct immunoassays in steroid hormone measurements, and points out some of the important challenges facing the rapid increase in usage of MS assays...
  49. ncbi Cyclosporine in patients with steroid-resistant membranous nephropathy: a randomized trial
    D C Cattran
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 59:1484-90. 2001
    ..Cyclosporine has been shown to be effective in cases of progressive MGN, but it has not been used in controlled studies at an early stage of the disease...
  50. pmc Cardiac steroids induce changes in recycling of the plasma membrane in human NT2 cells
    Haim Rosen
    The Kuvin Center for the Study of Infectious and Tropical Diseases, Institute of Microbiology, Jerusalem, Israel
    Mol Biol Cell 15:1044-54. 2004
    Cardiac steroids (CSs) are specific inhibitors of Na+, K(+)-ATPase activity. Although the presence of CS-like compounds in animal tissues has been established, their physiological role is not evident...
  51. ncbi Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen receptor and to their anabolic and androgenic activities. Applied modifications in the steroidal structure
    A G Fragkaki
    Doping Control Laboratory of Athens, Olympic Athletic Center of Athens Spyros Louis, Kifisias 37, 15123 Maroussi, Greece
    Steroids 74:172-97. 2009
    Anabolic androgenic steroids (AAS) are synthetic derivatives of testosterone introduced for therapeutic purposes providing enhanced anabolic potency with reduced androgenic effects...
  52. pmc Three redundant brassinosteroid early response genes encode putative bHLH transcription factors required for normal growth
    Danielle M Friedrichsen
    Plant Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genetics 162:1445-56. 2002
    Brassinosteroids (BRs) are a class of polyhydroxylated steroids that are important regulators of plant growth and development...
  53. ncbi Polyhydroxy steroids and saponins from China Sea starfish Asterina pectinifera and their biological activities
    Yan Peng
    College of Light Industry and Food Sciences, South China University of Technology
    Chem Pharm Bull (Tokyo) 58:856-8. 2010
    ..2, 0.05, 0.2, 0.22, and 0.07 microM, respectively. While compounds 4 and 5 exhibited cytotoxicity against HepG2 cells with IC(50) values of 0.2 and 1.6 microM, respectively...
  54. ncbi Tonsillectomy and steroid pulse (TSP) therapy for patients with IgA nephropathy: a nationwide survey of TSP therapy in Japan and an analysis of the predictive factors for resistance to TSP therapy
    Naoto Miura
    Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi, 480 1195, Japan
    Clin Exp Nephrol 13:460-6. 2009
    ..Am J Kidney Dis 38:736-742, 2001) based on data that about 50% of patients achieved clinical remission (CR) of urinary abnormalities...
  55. ncbi Multi-residue analysis of steroids at sub-ng/L levels in surface and ground-waters using liquid chromatography coupled to tandem mass spectrometry
    Emmanuelle Vulliet
    Service Central d Analyse du CNRS USR59, Chemin du Canal, B P 22, F 69360 Solaize, France
    J Chromatogr A 1210:84-91. 2008
    Most analytical methodologies currently available for the determination of steroids in water only identify a few representative compounds (mainly estrogens)...
  56. ncbi Inhaled drugs as risk factors for community-acquired pneumonia
    J Almirall
    Critical Care Unit, Hospital de Mataro, Universitat Autonoma de Barcelona, CIBER Enfermedades Respiratorias, Barcelona, Spain
    Eur Respir J 36:1080-7. 2010
    ..In COPD patients, inhaled steroids had a risk OR of 3.26 (95% CI 1.07-9.98) and in asthma patients inhaled anticholinergics had a risk OR of 8...
  57. ncbi Steroids and sesquiterpenoids from the soft corals Dendronephthya gigantea and Lemnalia cervicorni
    Chang Yih Duh
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung, Taiwan, Republic of China
    J Nat Prod 67:1650-3. 2004
    One new cytotoxic steroid, dendronesterone A (1), two new steroids, dendronesterones B and C (2 and 3), and a known steroid (4) were isolated from the methylene chloride solubles of the Formosan soft coral Dendronephthya gigantea...
  58. ncbi Injection treatment and back pain associated with degenerative lumbar spinal stenosis in older adults
    Virginia G Briggs
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Pain Physician 13:E347-55. 2010
    ..Injection treatment is a commonly used non-surgical procedure to alleviate lower back pain in older adults. However, the effectiveness of injection treatment, particularly in older adults, has not been well documented...
  59. ncbi Influence of steroids on HCV recurrence after liver transplantation: A prospective study
    Marco Vivarelli
    Department of Surgery and Transplantation, University of Bologna, Italy
    J Hepatol 47:793-8. 2007
    To assess the effect of long-term maintenance of steroids on HCV recurrence after liver transplantation (LT), that is still controversial, a prospective multicentre trial was conducted at the centres of Bologna and Padua, Italy.
  60. ncbi Treatment of nephrotic idiopathic membranous nephropathy with monthly i.v. pulse cyclophosphamide and oral steroids: a single centre's retrospective study
    Jiangzi Yuan
    Renal Division, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Nephrology (Carlton) 16:440-5. 2011
    ..is controversial, some trials have suggested positive outcomes following treatment with oral cyclophosphamide used in combination with steroids. However, data on i.v. cyclophosphamide plus steroids in treatment of nephrotic IMN are few.
  61. pmc Bioactive polyoxygenated steroids from the South China sea soft coral, Sarcophyton sp
    Zenglei Wang
    Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China
    Mar Drugs 11:775-87. 2013
    Seven new polyoxygenated steroids (1-7) were isolated together with seven known analogues (8-14) from the South China Sea soft coral, Sarcophyton sp...
  62. ncbi Benefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroids
    D C Grootendorst
    Dutch Asthma Centre, Davos, Switzerland
    Clin Exp Allergy 31:400-8. 2001
    Some patients with severe asthma cannot be controlled with high doses of inhaled steroids (ICS), which may be related to ongoing environmental allergen exposure...
  63. ncbi Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids
    H Berglund
    Department of Medicine, Division of Neurology, Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska University Hospital, Karolinska Institute, MR Centre, Stockholm, Sweden
    Cereb Cortex 18:1900-8. 2008
    ..These steroids are reported to activate the hypothalamic networks in a sex-differentiated way...
  64. ncbi Early B-lymphocyte precursors and their regulation by sex steroids
    P W Kincade
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Immunol Rev 175:128-37. 2000
    ..This new model was used to advantage in our studies of sex steroids. It appears that early precursors represent a hormone-sensitive control point for determining numbers of new B ..
  65. ncbi Chemical constituents and bioactivities of starfish
    Guang Dong
    Key Laboratory of Marine Bio resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, P R China
    Chem Biodivers 8:740-91. 2011
    ....
  66. ncbi Structural diversity of neuritogenic substances and their application perspective
    J Qi
    College of Pharmaceutical Sciences, Zhejiang University, Yu Hang Tang Road, Hangzhou, China
    Mini Rev Med Chem 11:658-77. 2011
    ..Increasing experimental evidence suggests that several of these compounds can be promising candidates for drug development...
  67. ncbi Liquid chromatography tandem mass spectrometry for analysis of steroids in clinical laboratories
    Mark M Kushnir
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
    Clin Biochem 44:77-88. 2011
    ..In the past, immunoassays were the primary methodology for analysis of steroids in biological samples because they are rapid and easy to perform...
  68. ncbi Recent advances in applied and mechanistic aspects of the enzymatic hydroxylation of steroids by whole-cell biocatalysts
    H L Holland
    Department of Chemistry, Brock University, St Catharines, ON, Canada
    Steroids 64:178-86. 1999
    ..Mechanistic factors that control the regiochemistry and stereochemistry of steroid hydroxylation are also discussed...
  69. pmc Sample preparation and liquid chromatography-tandem mass spectrometry for multiple steroids in mammalian and avian circulation
    Lee Koren
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 7:e32496. 2012
    ..samples from wild mammals and birds are often limited in volume, allowing researchers to quantify only one or two steroids from a single sample by immunoassays...
  70. pmc Phosphatidylethanolamine of Helicobacter pylori functions as a steroid-binding lipid in the assimilation of free cholesterol and 3β-hydroxl steroids into the bacterial cell membrane
    Hirofumi Shimomura
    Division of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan
    J Bacteriol 194:2658-67. 2012
    ..Further, HpPE interacted with 3β-OH steroids, pregnenolone and dehydroepiandrosterone, in the absence of dMβCD...
  71. ncbi Ceragenins (cationic steroid compounds), a novel class of antimicrobial agents
    Richard M Epand
    Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    Drug News Perspect 21:307-11. 2008
    ..Factors contributing to the mechanism of action of these agents are discussed. The ceragenins are a class of agents with many properties to make them favorable for application as antiinfective agents...
  72. ncbi Reference ranges for urinary concentrations and ratios of endogenous steroids, which can be used as markers for steroid misuse, in a Caucasian population of athletes
    Pieter Van Renterghem
    DoCoLab UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Steroids 75:154-63. 2010
    The detection of misuse with naturally occurring steroids is a great challenge for doping control laboratories. Intake of natural anabolic steroids alters the steroid profile...
  73. ncbi Current controversies in Niemann-Pick C1 disease: steroids or gangliosides; neurons or neurons and glia
    Robert P Erickson
    Department of Pediatrics, University of Arizona, Tucson, AZ 85724 5073, USA
    J Appl Genet 54:215-24. 2013
    ..More research will be needed in order to definitively solve the second controversy...
  74. ncbi The role of plasma-binding proteins in the cellular uptake of lipophilic vitamins and steroids
    T K Andreassen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Horm Metab Res 38:279-90. 2006
    ..work using a megalin-deficient mouse model has identified a new endocytic pathway responsible for the delivery of steroids to renal and gonadal tissues...
  75. ncbi Rapid regulatory actions of sex steroids on cell movement through the actin cytoskeleton
    Maria Silvia Giretti
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Steroids 73:895-900. 2008
    ..Sex steroids, particularly estrogen and progesterone, are effective regulators of cell migration and tissue organization, and ..
  76. ncbi Steroid glycosides from marine organisms
    Natalia V Ivanchina
    Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr 100 Let Vladivostoku 159, 690022 Vladivostok, Russia
    Steroids 76:425-54. 2011
    ..Structures, taxonomic distribution and biological activities of steroid glycosides isolated from marine organisms over the last 8-10 years are reviewed. The bibliography includes 130 references...
  77. pmc Membranous nephropathy in children: clinical presentation and therapeutic approach
    Shina Menon
    The Carman and Ann Adams Department of Pediatrics, Division of Nephrology, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
    Pediatr Nephrol 25:1419-28. 2010
    ..Those with nephrotic syndrome are usually treated with steroids initially and often followed by alkylating agents (cyclophosphamide or chlorambucil)...
  78. ncbi Concentrations of steroids and expression of messenger RNA for steroidogenic enzymes and gonadotropin receptors in bovine ovarian follicles of first and second waves and changes in second wave follicles after pulsatile LH infusion
    M Manikkam
    Department of Animal Sciences, University of Missouri Columbia, Columbia, MO 65211 5300, USA
    Anim Reprod Sci 67:189-203. 2001
    ..In conclusion, follicular fluid concentrations of E2 and A4 were lower in W2S than in W1S and E2 and A4 concentrations were restored by infusion of LH in W2LH with an increase in mRNA expression of P450c17 and 3beta-HSD...
  79. pmc Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting
    Norleena P Gullett
    Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA
    Am J Clin Nutr 91:1143S-1147S. 2010
    ..The clinical and anabolic efficacy of specific growth factors and anabolic steroids (eg, growth hormone, testosterone, megestrol acetate) in malnutrition and other catabolic states has been the ..
  80. ncbi Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: comparison of grading systems
    Margaret L Macmillan
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Biol Blood Marrow Transplant 8:387-94. 2002
    ..Lower initial GVHD grade (I-II or A-B) led to better survival. These data suggest that steroids provide an active but inadequate therapy for acute GVHD, especially with higher grade GVHD...
  81. ncbi Clinicopathologic characteristics and steroid response of IgM nephropathy in children presenting with idiopathic nephrotic syndrome
    Muhammed Mubarak
    Histopathology and Nephrology Departments, Sindh Institute of Urology and Transplantation, Karachi, Pakistan
    APMIS 119:180-6. 2011
    ..C3 and C1q were found in 72 (53.3%) and 40 (29.7%) cases, respectively. Our results show that IgMN is a fairly common cause of INS in children in Pakistan. It shows a spectrum of morphologic changes ranging from minor changes to FSGS...
  82. ncbi Caudal epidural injections in the management of chronic low back pain: a systematic appraisal of the literature
    Allan T Parr
    Premier Pain Center, Covington, LA, USA
    Pain Physician 15:E159-98. 2012
    Epidural injections with local anesthetics and steroids are one of the most commonly used interventions in managing chronic low back pain and lower extremity pain of various causes...
  83. ncbi Measurement of fish steroids in water--a review
    Alexander P Scott
    The Centre for Environment, Fisheries and Aquaculture Science, Weymouth, Dorset, DT4 8UB, UK
    Gen Comp Endocrinol 153:392-400. 2007
    Measurement of fish steroids in water provides a non-invasive alternative to measurement in blood samples, offering the following advantages: zero or minimal intervention (i.e...
  84. ncbi Early myocardial dysfunction after chronic use of anabolic androgenic steroids: combined pulsed-wave tissue Doppler imaging and ultrasonic integrated backscatter cyclic variations analysis
    Roberta Montisci
    Clinical Cardiology, University of Cagliari, Cagliari, Italy
    J Am Soc Echocardiogr 23:516-22. 2010
    The chronic consumption of androgenic anabolic steroids (AAS) has shown to cause subclinical impairment of myocardial function...
  85. ncbi Effectiveness of therapeutic lumbar transforaminal epidural steroid injections in managing lumbar spinal pain
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 15:E199-245. 2012
    ..However, there are only a few well-designed, randomized, controlled studies on the effectiveness of steroid injections. Consequently, multiple systematic reviews with diverse opinions have been published...
  86. ncbi Measurement of sex steroids in murine blood and reproductive tissues by liquid chromatography-tandem mass spectrometry
    K M McNamara
    Andrology, ANZAC Research Institute, University of Sydney, Sydney, NSW 2139, Australia
    J Steroid Biochem Mol Biol 121:611-8. 2010
    Accurate measurement of sex steroids is essential to evaluate mouse models for human reproductive development and disorders...
  87. pmc PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids
    K Tan
    Department of Neurology, 509 Pathology, 600 N Wolfe St, Baltimore, MD 21287, USA
    Neurology 72:1458-64. 2009
    ..We describe the types of PML in relation to immune reconstitution inflammatory syndrome (IRIS) and the effects of steroid use in these patients...
  88. ncbi Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae
    Horng Huey Ko
    Faculty of Fragrance and Cosmetics, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC
    Phytochemistry 69:234-9. 2008
    The antiinflammatory properties of triterpenoids and steroids from both Ganoderma lucidum and Ganoderma tsugae were studied...
  89. ncbi New anti-inflammatory 4-methylated steroids from the Formosan soft coral Nephthea chabroli
    Ya Ching Huang
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung, Taiwan
    Steroids 73:1181-6. 2008
    Eight new 4-methylated steroids, nebrosteroids A-H (1-8) were isolated from the acetone solubles of the Formosan soft coral Nephthea chabroli...
  90. ncbi The relevance of neuroactive steroids in schizophrenia, depression, and anxiety disorders
    Erin M MacKenzie
    Bebensee Schizophrenia Research Unit, Department of Psychiatry, University of Alberta, Canada
    Cell Mol Neurobiol 27:541-74. 2007
    1. Neuroactive steroids are steroid hormones that exert rapid, nongenomic effects at ligand-gated ion channels...
  91. ncbi Endogenous steroids are responsible for lactoferrin-induced myelopoiesis in mice
    Michał Zimecki
    Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
    Pharmacol Rep 61:705-10. 2009
    ..We conclude that LF-induced upregulation of endogenous steroid levels is responsible for the stimulation of myelopoiesis...
  92. ncbi Evidence for a key role of steroids in the modulation of pain
    Ayikoe G Mensah-Nyagan
    Equipe Stéroïdes, Neuromodulateurs et Neuropathologies, Universite de Strasbourg, Bâtiment 3 de la Faculté de Médecine, 11 rue Humann, 67000 Strasbourg, France
    Psychoneuroendocrinology 34:S169-77. 2009
    ..Because steroids control the development, activities and plasticity of the nervous system, these compounds are of particular ..
  93. ncbi New 4-methylated and 19-oxygenated steroids from the Formosan soft coral Nephthea erecta
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung, Taiwan
    Steroids 72:653-9. 2007
    Two new 4-methylated steroids, erectasteroids A and B (1 and 2), six new 19-oxygenated steroids, erectasteroids C-H (3-8) and two known 19-oxygenated steroids (9 and 10) were isolated from the acetone solubles of the Formosan soft coral ..
  94. pmc Study protocol- Lumbar Epidural steroid injections for Spinal Stenosis (LESS): a double-blind randomized controlled trial of epidural steroid injections for lumbar spinal stenosis among older adults
    Janna L Friedly
    Comparative Effectiveness, Cost and Outcomes Research Center, University of Washington, Seattle, USA
    BMC Musculoskelet Disord 13:48. 2012
    ..prospective, double-blind, randomized controlled trial that tests the hypothesis that epidural injections with steroids plus local anesthetic are more effective than epidural injections of local anesthetic alone in improving pain and ..
  95. ncbi Sesquiterpenoids and artificial 19-oxygenated steroids from the formosan soft coral Nephthea erecta
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung, Taiwan, Republic of China
    J Nat Prod 70:1449-53. 2007
    ..have afforded five new sesquiterpenoids (1-5), one known sesquiterpene, kelsoene (6), and two known 19-oxygenated steroids (10 and 11)...
  96. ncbi New cytotoxic steroids from the soft coral Clavularia viridis
    Chang Yih Duh
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung, Taiwan
    Steroids 72:573-9. 2007
    Ten new cytotoxic steroids, stoloniferones H-Q (1-10) were isolated from the methylene chloride solubles of the soft coral Clavularia viridis...
  97. ncbi Sex steroids and brain structure in pubertal boys and girls: a mini-review of neuroimaging studies
    J S Peper
    Leiden Institute of Psychology, Brain and Development Laboratory, Leiden University, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands
    Neuroscience 191:28-37. 2011
    ..From animal studies it has become clear that sex steroids are capable of influencing brain organization, both during the prenatal period as well as during other periods ..
  98. ncbi 5alpha-reduced C21 steroids are substrates for human cytochrome P450c17
    Manisha K Gupta
    Division of Endocrinology and Metabolism, Department of Internal Medicine, 5323 Harry Hines Blvd, Dallas, TX 75390 8857, USA
    Arch Biochem Biophys 418:151-60. 2003
    ..of testosterone in target tissues is a key step in androgen physiology; however, 5alpha-reduced C(19) steroids are sometimes synthesized in testis via a pathway that does not involve testosterone as an intermediate...
  99. ncbi Protocol for evaluation of the comparative effectiveness of percutaneous adhesiolysis and caudal epidural steroid injections in low back and/or lower extremity pain without post surgery syndrome or spinal stenosis
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 13:E91-E110. 2010
    Treatment of chronic low back pain with or without lower extremity pain continues to be a challenge. Epidural steroids are commonly utilized in patients after the failure of conservative treatment...
  100. ncbi Percutaneous adhesiolysis in the management of chronic low back pain in post lumbar surgery syndrome and spinal stenosis: a systematic review
    Standiford Helm Ii
    Pacific Coast Pain Management Center, Laguna Hills, CA, USA
    Pain Physician 15:E435-62. 2012
    ..the catheter in the ventro-lateral aspect of the epidural space at the site of the exiting nerve root, and the use of high volumes of injectate, including local anesthetics and saline, either hypertonic or isotonic, along with steroids.
  101. ncbi Androgen synthesis in adrenarche
    Walter L Miller
    Department of Pediatrics, University of California, Room 672 S, San Francisco, CA 94143 0978, USA
    Rev Endocr Metab Disord 10:3-17. 2009
    ..In the absence of P450c17 in the zona glomerulosa, C21 deoxy steroids are produced, leading to the mineralocorticoid, aldosterone...

Research Grants74

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..Cytokines secondary to inflammation and exogenous treatment with steroids can cause mood and cognitive changes in these same brain regions...
  2. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..These changes may be due to direct ovarian effects on lipoprotein metabolism, and/or steroids secreted from the ovary having systemic effects on the liver or other organs...
  3. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..Thus, regardless of gender, these secreted steroids are converted peripherally into divergent signals for two members of the steroid hormone nuclear receptor family...
  4. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neurosteroids, steroids synthesized de novo in the brain, have been implicated in functions ranging from stress, depression, anxiety, to cognition...
  5. Epigenetics of Sex Differences in Brain and Behavior
    BRIDGET NUGENT; Fiscal Year: 2012
    ..That developmental exposure to gonadal steroids organizes enduring changes in brain and behavior is one of the central tenets of neuroendocrinology, but the ..
  6. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..of both inner ear ion homeostatic and inflammatory gene expression processes by combination doses of the two steroids. Aim 3: Determine which cochlear cellular and molecular functions are mediated by each steroid receptor...
  7. Molecular Regulation of Progesterone Synthesis
    John S Davis; Fiscal Year: 2013
    ..In both men and women steroids control many vital processes, including carbohydrate, lipid, and protein metabolism, and sexual function...
  8. Sex Steroid Hormone Regulation of Drug Reinforcement
    Diane Lebesgue; Fiscal Year: 2012
    ..Surprisingly little is known about the influence of ovarian steroids on the mesolimbic drug reward circuits, especially the possibility that estradiol rapidly modulates synaptic ..
  9. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..acids not only are physiological detergents that facilitate absorption, transport, distribution and disposal of steroids, nutrients, vitamins, metabolites and xenobiotics, but also are signaling molecules that activate nuclear ..
  10. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..GVHD is most often treated with high doses of steroids, a therapy that is not always effective and associated with substantial side effects...
  11. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ..The reproductive steroids, E and T can also modulate stress responses. Circulating E enhances stress activated ACTH and CORT secretion...
  12. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..status;carotenoids and other antioxidants;one-carbon metabolism;energy balance, insulin, and growth factors;sex steroids;and genetic variants impacting these exposures...
  13. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
  14. Aldosterone Action In The Brain, Hypertension and Inflammation
    ELISE PEERY GOMEZ-SANCHEZ; Fiscal Year: 2012
    ..Plasma and tissue concentrations of adrenal steroids and proinflammatory cytokines associated with mineralocorticoid- induced end-organ damage will be measured by ..
  15. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..In this proposal we hypothesize that these novel non-hormonal steroids significantly reduce inflammation and improve muscle function, arthritis and asthma phenotypes without causing ..
  16. Runx Proteins and Sex Steroid Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2009
    Technical Abstract Sex Steroids and Runx Signaling in Bone The following contains proprietary/privileged information that Dr...
  17. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..There is no known specific treatment, although palliative measures such as antihypertensive drugs, magnesium, and steroids, and early delivery improve outcomes...
  18. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Evidence supporting sex steroids as being essential for normal cognitive health includes: 1) 12 studies demonstrating improvements in cognitive performance of cognitively healthy postmenopausal women ..
  19. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..The Antenatal Steroids for Term Cesarean Section study reported that two doses of antenatal betamethasone significantly reduced ..
  20. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ..Uterine responsive to exogenous steroids is intact in CYP27b1 and VDR knockout mice, thus suggesting that vitamin D3 deficiency impairs one or more ..
  21. Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
    Catherine M Gordon; Fiscal Year: 2013
    ..mediators of the changes observed in both bone density and bone marrow composition, including adrenal and gonadal steroids, insulin-like growth factors, growth hormone, and ghrelin, adiponectin, and leptin...
  22. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2010
    Bile acids are physiological agents that facilitate absorption, transport and disposal of steroids, nutrients, metabolites and xenobiotics...
  23. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce S McEwen; Fiscal Year: 2013
    ....
  24. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..A characteristic feature of the menopause is a marked attenuation in the production and release of ovarian steroids, such as estradiol and progesterone...
  25. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2013
    ..In this proposal we hypothesize that these novel non-hormonal steroids significantly reduce inflammation and improve muscle function, arthritis and asthma phenotypes without causing ..
  26. Sex Steroids and Runx Signaling in Bone
    Baruch Frenkel; Fiscal Year: 2013
    ..The proskeletal effects of sex steroids are mediated by anabolic effects in osteoblasts, but more importantly by attenuating bone resorption...
  27. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    ..study will focus on the hormones most different between the sexes in adults and late adolescents: androgenic steroids and estrogen, leptin and prolactin...
  28. Effect of Neonatal Hyperoxia on Alveolar Development and Infection
    MICHAEL A O'REILLY; Fiscal Year: 2012
    ABSTRACT Despite the use of exogenous surfactant, steroids, and mild ventilation, premature infants often require oxygen assistance and many develop bronchopulmonary dysplasia (BPD)...
  29. StAR expression: Integration of Transcription with regulation via the mRNA 3'UTR
    COLIN ROBERT JEFCOATE; Fiscal Year: 2012
    ..TIS11b regulation is present in other tissues that make steroids (testis)...
  30. Endocrine Targets for Prevention of Lung Cancer
    Robert M Bigsby; Fiscal Year: 2012
    ..Thus, receptors for ovarian steroids are logical targets for intervention...
  31. Development of Montelukast Delivery System for Childhood Asthma
    Je Phil Ryoo; Fiscal Year: 2013
    ..Ng et al 2004), as patients on antileukotrienes are more likely to suffer an exacerbation requiring systemic steroids and to exhibit a lesser improvement in lung function...
  32. Glucocorticoids, Stress and Blood Pressure Regulation
    Deborah A Scheuer; Fiscal Year: 2013
    ..Aims 1 and 2 utilize a validated technique to chronically deliver steroids selectively to the dorsal hindbrain by implantation of small pellets...
  33. Modulation of Colonic Epithelial Permeability by Sex Hormones
    Muriel Larauche; Fiscal Year: 2013
    ..Paul Micevych, Professor in the Department of Neurobiology at UCLA and expert in the sex steroids field, in particular in the cellular and molecular events underlying estrogen's profound effects on pain...
  34. Regulation Of Inorganic Phosphorus (Pi) Metabolism By Estrogen
    Hassane Amlal; Fiscal Year: 2013
    ..objective of this proposal is to study the regulation of inorganic phosphorus (Pi) homeostasis by female sex steroids, mainly Estrogen (E2)...
  35. Role of VEGF in Perinatal Hypertension
    STEVEN HERBERT ABMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Advances in perinatal care, including antenatal steroids, surfactant therapy and improved ventilator strategies, have markedly increased survival of extremely low birth weight infants...
  36. Developmental Regulation of Brain and Behavior
    JULI S WADE; Fiscal Year: 2011
    ..While the roles of sex steroids in development of neural circuitry are well established for many model systems, interactions between these ..
  37. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia M Kuhn; Fiscal Year: 2012
    ..We have shown that removal of gonadal steroids has marked and opposite effects on DA neuron number in the substantia nigra/ventral tegmental area in male and ..
  38. Neural Control of the Circulation: Sex and Hypertension
    Baojian Xue; Fiscal Year: 2013
    ..understanding of cellular and brain mechanisms underlying the effects of sex estrogen receptor subtypes, and sex steroids in the pathogenesis of hypertension is critical for the continued development of therapies to treat ..
  39. The Role of Estradiol and Sex in the Effects of Ghrelin on Meal Patterns and Fos-
    PETER BUTERA; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Gonadal steroids are among the numerous factors influencing food intake and body weight in mammals...
  40. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
    ..also utilizes E2-mediated pathway in restoring immune functions in males, leads us to hypothesize that female sex steroids play a critical role in maintaining cell signaling homeostasis and the immune cell functions in various tissue ..
  41. The Role of Cyp2b in Toxicant Metabolism and Sensitivity
    William S Baldwin; Fiscal Year: 2012
    ..The cytochrome P450s (CYPs) are key enzymes involved in the detoxification of numerous chemicals including steroids, bile acids, pharmaceuticals, and environmental chemicals...
  42. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Repeated intravitreal injections of steroids and anti-VEGF agents in the treatment of macular edema, pose potential post-surgical problems...
  43. CELLS PROCESSING HIGH DENSITY LIPOPROTEINS
    Salman Azhar; Fiscal Year: 2013
    ..Likewise, adrenal steroids influence carbohydrate, lipid, and protein metabolism, and salt and water balance, as well as inflammation, ..
  44. Functions of the Human OST-alpha and OST-beta Proteins
    Patricia M Hinkle; Fiscal Year: 2013
    ..the functional Ost?-Ost? transporter;and second, that the Ost?-Ost?-mediated transport of bile acids and related steroids modulates lipid homeostasis...
  45. CIRCUITS MEDIATING BEHAVIORAL CONSEQUENCES OF STEROID SENSATION
    Timothy E Holy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Steroid hormones regulate many aspects of mammalian physiology. Steroids pass through membranes and bind to nuclear receptor/transcription factors, initiating a change in gene transcription...
  46. Developing Nrf2 as a target for treatment of corticosteroid resistance in COPD
    Robert A Wise; Fiscal Year: 2012
    ..Identification of drug targets that can improve efficacy of steroids to suppress ain/vay inflammation can significantly reduce morbidity and progression of the disease...
  47. PROGESTERONE RECEPTOR AND ACTION IN THE PRIMATE OVARY
    Richard L Stouffer; Fiscal Year: 2013
    ..understand the mechanisms whereby luteinizing hormone (LH) either directly, or indirectly via locally synthesized steroids, regulates the structure-function of the peri-ovulatory follicle or corpus luteum (CL) in primates during the ..
  48. Role of Focal Adhesion Kinase (FAK) in Nephrosis and Nephritis
    Shuta Ishibe; Fiscal Year: 2013
    ..Angiotensin Converting Enzyme Inhibitor, Steroids, and Alkylating Agents...
  49. SIMULATION OF PROTON AND HYDRIDE TRANSFER IN ENZYMES
    Sharon Hammes Schiffer; Fiscal Year: 2010
    ..The fourth specific aim centers on the enzyme ketosteroid isomerase (KSI), which catalyzes the isomerization of steroids. In mammals, this enzyme is medically relevant in that it controls the synthesis of steroid hormones...
  50. Systemic Application for Injury Site Specific Delivery via Neutrophils to Treat B
    XUDONG J LI; Fiscal Year: 2013
    ..As such, the use of fluoroscopy-guided lumbar epidural injections of steroids to reduce the local chemo-inflammatory response has increased dramatically since their inception as a treatment ..
  51. Participation in Cytochrome b5 in Anesthetic Metabolism
    Lucy A Waskell; Fiscal Year: 2010
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
  52. REGULATION OF STROMAL WOUND HEALING BY GROWTH FACTORS
    GREGORY SCOTT SCHULTZ; Fiscal Year: 2012
    ..Clinical trials of anti-inflammatory steroids have not shown statistically significant benefit, and mitomycin C treatment carries the risk serious side effects...
  53. Novel Mechanisms Regulating the Adipocyte-Brain Hepatocyte Axis
    Philipp E Scherer; Fiscal Year: 2013
    ..revolve around the general theme of peripheral inflammatory factors, such as adipokines, dietary lipids, and sex steroids, engaging key sites in the brain...
  54. The Significance of Leptin Signals to Neonatal Somatotropes and Gonadotropes
    Gwen V Childs; Fiscal Year: 2013
    ..puberty, fertility, development of the reproductive organs, and somatotrope or gonadotrope responses to gonadal steroids. These studies will provide for the first time a focused view of the importance of leptin receptors to either ..
  55. Anabolic-androgenic steroids enhance motivation
    Ruth I Wood; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although anabolic-androgenic steroids (AAS) have legitimate medical uses, they are also drugs of abuse...
  56. Randomized Trial of Antenatal Late Preterm Steroids (ALPS) - Clinical Coordinatin
    Ronald Wapner; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The use of antenatal steroids to accelerate fetal lung development and induce endogenous surfactant production is perhaps one of the most important advances in the field of obstetrics to improve the ..
  57. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    Joanne E Fortune; Fiscal Year: 2010
    ..Our preliminary data suggest the overall hypothesis of this R21 application: that steroids produced by the fetal bovine ovary, particularly estradiol and progesterone, regulate both follicle formation and ..
  58. Oxygen Sensors and P450 Monooxygenases in Mycobacertium tuberculosis
    Paul R Ortiz de Montellano; Fiscal Year: 2013
    ..knockouts, NMR studies of protein conformational changes with 13C- and 19F-labeled site-specifically incorporated amino acids, and chemical biological studies of the roles of steroids and other factors in the biology of M. tuberculosis.
  59. The Kiss1 system in the neuroendocrine control of reproduction
    VICTOR MANUEL NAVARRO; Fiscal Year: 2013
    ..AVPV in the positive and negative feedback of sex steroids;and 3) determine the role of NKB in the ARC in the control of puberty in male and female mice...
  60. FUNCTIONAL ANALYSIS OF NUCLEAR RECEPTOR VARIANTS
    Curtis J Omiecinski; Fiscal Year: 2013
    ..exposures to drugs, other xenobiotics, and endogenous substances such as bile acids, thyroid hormone, heme, and steroids. Due to the importance of this receptor system as a determinant of xenobiotic disposition in man, together with ..
  61. A Prospective Study of Diet and Prostate Cancer
    Edward Giovannucci; Fiscal Year: 2011
    ..examine four inter-related pathogenic pathways for prostate carcinogenesis: the vitamin D axis, inflammation, sex steroids, and insulin/insulin-like growth factor signaling...
  62. Porcine Respiratory Coronavirus as a SARS Model
    Linda Saif; Fiscal Year: 2007
    ..The widespread use of steroids and IFNs for treatment of SARS patients without a clear understanding of their impact on respiratory disease, ..
  63. STEROID REGULATION OF ION CHANNELS
    Leslie Henderson; Fiscal Year: 1999
    ..It is well established that gonadal steroids act to induce permanent (organizational) sexual dimorphisms in regions of the mammalian brain that provide the ..
  64. Neuroactive Steroids and Seizure Control during Pregnancy in Women with Epilepsy
    PAGE BUCKHANNAN PENNELL; Fiscal Year: 2010
    ..hormones and the metabolic byproducts that are capable of modifying neural activity are classified as neuroactive steroids (NAS)...
  65. MOLECULAR STRUCTURE OF STEROIDS
    William Duax; Fiscal Year: 2001
    ..X-Ray crystal structure determinations of hormonal steroids and the proteins with which they interact are being undertaken, and correlations between molecular conformation ..
  66. Impact of Puberty on the Kidney in Diabetes
    PASCALE LANE; Fiscal Year: 2005
    ..Given clinical differences in the prevalence and rate of progression between the sexes, gonadal steroids seem likely to be involved in these processes...
  67. MECHANISMS UNDERLYING ADRENAL STEROID MODULATION OF LTP
    Constantine Pavlides; Fiscal Year: 2000
    DESCRIPTION: Adrenal steroids modulate long-term potentiation (LTP) in the hippocampus...
  68. COGNITION, STEROIDS AND IMAGING IN CUSHINGS DISEASE
    MONICA STARKMAN; Fiscal Year: 2001
    ..The investigator's objective is to examine the role of steroids in the pathophysiology of behavior by exploiting the fact that patients with CD are a unique model providing ..
  69. Preoperative Therapy for Prevention of Postoperative Low Cardiac Output Syndrome
    D Woodrow Benson; Fiscal Year: 2010
    ..clinical trial, to investigate whether preoperative administration of glucocorticoids (methylprednisolone, steroids) and/or erythropoietin (EPO) will afford protection from ischemia-reperfusion injury and thereby reduce the ..
  70. ION CHANNEL TARGETS FOR CARDIAC GLYCOSIDE ACTIONS
    J Wasserstrom; Fiscal Year: 2000
    ..The purpose of this project is to investigate new subcellular actions of several cardiotonic steroids on regulation of ion channels and contraction in heart...
  71. A NEW NEUROENDOCRINE MODEL OF SEASONAL BEHAVIORS
    MARY MENDONCA; Fiscal Year: 2001
    ..They 1) have a dissociated pattern of reproduction, mating when gonads are regressed and sex steroids are basal, and 2) are heterothermic, with arousal from hibernation being a potent and rapid stimulator of sexual ..
  72. METABOLIC TRANSFORMATION OF STEROIDS IN BREAST CELLS
    Rajeshwari Mehta; Fiscal Year: 1992
    ..Recently, local metabolic transformation of steroids is thought to be of primary importance in providing an estradiol source to human breast tumors...
  73. Sex Steroids, and TMJ Pain
    Larry Bellinger; Fiscal Year: 2009
    ..gender differences in pain in the TMJ and surrounding region by determining the modulatory effect of sex steroids in males...