Genomes and Genes
Summary: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
Publications360 found, 100 shown here
- Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophreniaD Umbricht
Psychiatric University Hospital, Department of Research, PO Box 68, Zurich 8029, Switzerland
Arch Gen Psychiatry 57:1139-47. 2000..In this study, effects of the NMDAR antagonists ketamine on MMN generation and AX-CPT performance were investigated in healthy volunteers to test the hypothesis that ..
- mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonistsNanxin Li
Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
Science 329:959-64. 2010The rapid antidepressant response after ketamine administration in treatment-resistant depressed patients suggests a possible new approach for treating mood disorders compared to the weeks or months required for standard medications...
- A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depressionCarlos A Zarate
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services, Bethesda, MD 20892, USA
Arch Gen Psychiatry 63:856-64. 2006..Converging lines of evidence suggest the role of the glutamatergic system in the pathophysiology and treatment of mood disorders...
- Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposureNanxin Li
Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
Biol Psychiatry 69:754-61. 2011....
- Synaptic mechanisms underlying rapid antidepressant action of ketamineEge T Kavalali
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, USA
Am J Psychiatry 169:1150-6. 2012Recent clinical studies have demonstrated that a single subpsychotomimetic dose of ketamine, an ionotropic glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonist, produces a rapid antidepressant response in patients with major ..
- Signaling pathways underlying the rapid antidepressant actions of ketamineRonald S Duman
Departments of Psychiatry and Neurobiology, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
Neuropharmacology 62:35-41. 2012..Recent clinical studies have demonstrated that ketamine, an NMDA receptor antagonist produces a rapid antidepressant response (within hours) and is effective in ..
- Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptorsSungho Maeng
Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Biol Psychiatry 63:349-52. 2008b>Ketamine exerts a robust, rapid, and relatively sustained antidepressant effect in patients with major depression...
- GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effectsJeffrey Burgdorf
Department of Biomedical Engineering, Falk Center for Molecular Therapeutics, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, IL 60201, USA
Neuropsychopharmacology 38:729-42. 2013Recent human clinical studies with the NMDA receptor (NMDAR) antagonist ketamine have revealed profound and long-lasting antidepressant effects with rapid onset in several clinical trials, but antidepressant effects were preceded by ..
- Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depressionHiroyuki Koike
Discovery Pharmacology, Molecular Function and Pharmacology Laboratories, Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Kita ku, Saitama, Saitama 331 9530, Japan
Behav Brain Res 224:107-11. 2011..In clinical studies, an N-methyl-d-aspartate receptor antagonist, ketamine, was shown to exert both rapid and sustained antidepressant effects in patients with treatment-resistant MDD...
- Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortexRong Jian Liu
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 71:996-1005. 2012..of BDNF messenger RNA, that loss-of-function Met allele mice would show synaptic deficits both at baseline and in response to ketamine, an N-methyl-D-aspartate antagonist that stimulates synaptogenesis in prefrontal cortex (PFC).
- Dexmedetomidine-ketamine combination mitigates acute lung injury in haemorrhagic shock ratsChen Hsien Yang
Department of Anaesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
Resuscitation 80:1204-10. 2009..Dexmedetomidine and ketamine possess potent anti-inflammatory capacity...
- Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatmentMiriam Kron
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
J Neurosci 32:13860-72. 2012..reduced Fos expression, as well as abnormal sensorimotor function, were reversed by the NMDA receptor antagonist ketamine. In light of recent findings that the default mode network is hypoactive in autism, our data raise the ..
- Ketamine for treatment-resistant unipolar depression: current evidenceSanjay J Mathew
Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
CNS Drugs 26:189-204. 2012..literature on the potential rapid-onset antidepressant properties of the glutamate NMDA receptor antagonist ketamine, an established anaesthetic agent...
- Ketamine use: a reviewCelia J A Morgan
Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, London, UK
Addiction 107:27-38. 2012b>Ketamine remains an important medicine in both specialist anaesthesia and aspects of pain management. At the same time, its use as a recreational drug has spread in many parts of the world during the past few years...
- Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosisPhilip R Corlett
Brain Mapping Unit, Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, England
Arch Gen Psychiatry 63:611-21. 2006..Establishing a neurobiological account of delusion formation that links cognitive processes, brain activity, and symptoms is important to furthering our understanding of psychosis...
- Ketamine disrupts theta synchrony across the septotemporal axis of the CA1 region of hippocampusJames R Hinman
Department of Psychology, University of Connecticut, Storrs, Connecticut 06269 1020, USA
J Neurophysiol 109:570-9. 2013..b>Ketamine is an N-methyl-D-aspartate (NMDA) antagonist that can decrease theta power...
- Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic painXiao peng Mei
Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi an, PR China
J Neuroinflammation 8:6. 2011..previously reported that inhibition of astrocytic activation contributes to the analgesic effects of intrathecal ketamine on spinal nerve ligation (SNL)-induced neuropathic pain. However, the underlying mechanisms are still unclear...
- Effect of three types of mixed anesthetic agents alternate to ketamine in miceSumiko Kawai
Department of Laboratory Animal Medicine, Osaka University, Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Exp Anim 60:481-7. 2011b>Ketamine is usually used for murine anesthesia in animal experiments with other anesthetics for its sedation and analgesic effects. However, ketamine was categorized as a narcotic drug in Japan on January 1, 2007...
- Quantifying the attenuation of the ketamine pharmacological magnetic resonance imaging response in humans: a validation using antipsychotic and glutamatergic agentsO M Doyle
King s College London, Department of Neuroimaging, Institute of Psychiatry, London, United Kingdom
J Pharmacol Exp Ther 345:151-60. 2013b>Ketamine acts as an N-methyl-D-aspartate receptor antagonist and evokes psychotomimetic symptoms resembling schizophrenia in healthy humans...
- Test-retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteersS De Simoni
King s College London, Department of Neuroimaging, Institute of Psychiatry PO89, De Crespigny Park, London SE5 8AF, UK
Neuroimage 64:75-90. 2013..b>Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, induces a strong phMRI response and represents a promising ..
- Modeling ketamine effects on synaptic plasticity during the mismatch negativityAndre Schmidt
University Hospital of Psychiatry, Neuropsychopharmacology and Brain Imaging
Cereb Cortex 23:2394-406. 2013..of mechanisms underlying the reduction of mismatch negativity (MMN) amplitudes under the NMDA-receptor antagonist ketamine. We applied dynamic causal modeling and Bayesian model selection to data from a recent ketamine study of the ..
- Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brainGislaine Z Réus
Laboratorio de Neurociencias, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
Behav Brain Res 221:166-71. 2011..of synergistic interactions between antidepressant imipramine with the uncompetitive NMDA receptor antagonist ketamine. Wistar rats were acutely treated with ketamine (5 and 10mg/kg) and imipramine (10 and 20mg/kg) and then ..
- Complex receptor mediation of acute ketamine application on in vitro gamma oscillations in mouse prefrontal cortex: modeling gamma band oscillation abnormalities in schizophreniaJ M McNally
Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, 940 Belmont Street, Research 151C, Brockton, MA 02301, USA
Neuroscience 199:51-63. 2011..For several decades, administration of sub-anesthetic levels of ketamine has provided the most comprehensive experimental model of Sz-symptoms...
- The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine toleranceJean Paul Laulin
Universite Bordeaux 1, France
Anesth Analg 94:1263-9, table of contents. 2002..We investigated postfentanyl morphine analgesic effects and the consequences of NMDA-receptor antagonist (ketamine) pretreatment. The rat nociceptive threshold was measured by the paw-pressure vocalization test...
- Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in ratsLêda S B Garcia
Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pos Graduacao em Ciencias da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 33:450-5. 2009..Additionally, studies have shown that ketamine induces antidepressant effects in humans as well as in rodents subjected to animal models of depression...
- Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depressionRebecca B Price
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
Biol Psychiatry 66:522-6. 2009Intravenous ketamine has shown rapid antidepressant effects in early trials, making it a potentially attractive candidate for depressed patients at imminent risk of suicide...
- Ketamine "unlocks" the reduced clock-speed effects of cocaine following extended training: evidence for dopamine--glutamate interactions in timing and time perceptionRuey Kuang Cheng
Department of Psychology and Neuroscience, Duke University, 572 Research Drive, Genome Sciences Research Building II, Box 91050, Durham, NC 27708, USA
Neurobiol Learn Mem 88:149-59. 2007..Importantly, when co-administered with a behaviorally ineffective dose of ketamine (10mg/kg, ip) the ability of cocaine to modulate clock speed in rats receiving extended training was restored...
- Paradoxical reaction following intravenous midazolam premedication in pediatric patients - a randomized placebo controlled trial of ketamine for rapid tranquilizationMohammad Golparvar
Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
Paediatr Anaesth 14:924-30. 2004..determine the incidence of paradoxical reactions following intravenous midazolam premedication in pediatric patients and to compare the efficacy of extra doses of midazolam with low-dose intravenous ketamine to rapidly tranquillize them.
- A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depressionNancy Diazgranados
Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Arch Gen Psychiatry 67:793-802. 2010..Pharmacological strategies that produce rapid antidepressant effects-for instance, within a few hours or days-would have an enormous impact on patient care and public health...
- N-methyl d-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant gamma oscillations in the rat neocortexDidier Pinault
INSERM U666, Physiopathologie Clinique et Expérimentale de la Schizophrénie, Faculte de Medecine, Strasbourg, France
Biol Psychiatry 63:730-5. 2008Single subanesthetic doses of ketamine, a non-competitive NMDA receptor (NMDAr) antagonist, induce cognitive impairment, schizophreniform psychosis, hallucinations, and exacerbate schizophrenia symptoms...
- Effects of ketamine in normal and schizophrenic volunteersA C Lahti
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Neuropsychopharmacology 25:455-67. 2001This study evaluates the effects of ketamine on healthy and schizophrenic volunteers (SVs) in an effort to define the detailed behavioral effects of the drug in a psychosis model...
- Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawalMartin S Angst
Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
Pain 106:49-57. 2003..infusion with the mu-opioid agonist remifentanil, and whether co-administration of the NMDA-receptor antagonist S-ketamine would prevent such hyperalgesia...
- Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeysM G Paule
Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
Neurotoxicol Teratol 33:220-30. 2011Previously our laboratory has shown that ketamine exposure (24h of clinically relevant anesthesia) causes significant increases in neuronal cell death in perinatal rhesus monkeys...
- Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia ratsChih Lin Yang
Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
J Surg Res 167:e273-81. 2011..Dexmedetomidine and ketamine are two sedative agents with potent anti-inflammatory capacity...
- Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrationsT A Bowdle
Department of Psychiatry, Harborview Medical Center, University of Washington, Seattle 98195, USA
Anesthesiology 88:82-8. 1998b>Ketamine has been associated with a unique spectrum of subjective "psychedelic" effects in patients emerging from anesthesia. This study quantified these effects of ketamine and related them to steady-state plasma concentrations.
- A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency departmentGregory Luke Larkin
Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT, USA
Int J Neuropsychopharmacol 14:1127-31. 2011We examined the preliminary feasibility, tolerability and efficacy of single-dose, intravenous (i.v.) ketamine in depressed emergency department (ED) patients with suicide ideation (SI)...
- Neurotoxicity of subarachnoid preservative-free S(+)-ketamine in dogsLyvia Maria R S Gomes
Department of Anesthesiology and Pain, Federal University of Maranhao, Brazil
Pain Physician 14:83-90. 2011Subarachnoid S(+)-ketamine is a matter of much debate as the results regarding its toxicity are contradictory.
- Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairmentsAndre Schmidt
Neuropsychopharmacology and Brain Imaging, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland
Neuropsychopharmacology 37:865-75. 2012Psychotomimetics like the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine and the 5-hydroxytryptamine2A receptor (5-HT(2A)R) agonist psilocybin induce psychotic symptoms in healthy volunteers that resemble those of schizophrenia...
- Ketamine depresses toll-like receptor 3 signaling in spinal microglia in a rat model of neuropathic painXiao peng Mei
Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi an, PR China
Neurosignals 19:44-53. 2011..In addition, ketamine application could suppress microglial activation in vitro, and ketamine could inhibit proinflammatory gene ..
- Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug actionMilan Scheidegger
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
PLoS ONE 7:e44799. 2012..underscores the strong and rapid antidepressant properties of the glutamate-modulating NMDA receptor antagonist ketamine. Targeting the glutamatergic system might thus provide a novel molecular strategy for antidepressant treatment...
- Ketamine for depression: where do we go from here?Marije aan het Rot
Department of Psychology and School of Behavioral and Cognitive Neuroscience, University of Groningen, The Netherlands
Biol Psychiatry 72:537-47. 2012Since publication of the first randomized controlled trial describing rapid antidepressant effects of ketamine, several reports have confirmed the potential utility of this dissociative anesthetic medication for treatment of major ..
- Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampusLêda S B Garcia
Laboratorio de Neurociencias, Programa de Pos Graduacao em Ciencias da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
Prog Neuropsychopharmacol Biol Psychiatry 32:140-4. 2008b>Ketamine is a non-competitive antagonist to the phencyclidine site of N-methyl-d-aspartate (NMDA) receptor. Clinical findings point to a rapid onset of action for ketamine on the treatment of major depression...
- Phenomenon of new drugs on the Internet: the case of ketamine derivative methoxetamineOrnella Corazza
School of Pharmacy, University of Hertfordshire, Hatfield, UK
Hum Psychopharmacol 27:145-9. 2012..This is a dissociative drug related to ketamine, with a much longer duration of action and intensity of effects...
- Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamineJianjun Pan
Department of Anesthesiology, Biomedical Science Tower 3, 3501 Fifth Avenue, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Structure 20:1463-9. 2012..GLIC, a prokaryotic pLGIC, can be inhibited by anesthetics, including ketamine. The ketamine concentration leading to half-maximal inhibition of GLIC (58 μM) is comparable to that on ..
- Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypassJudith A Hudetz
Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Administration Medical Center, Milwaukee, WI, USA
J Cardiothorac Vasc Anesth 23:651-7. 2009To determine if ketamine attenuates postoperative delirium concomitant with an anti-inflammatory effect in patients undergoing cardiac surgery using cardiopulmonary bypass.
- Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging studyJ F William Deakin
Neuroscience and Psychiatry Unit, The University of Manchester, G 907 Stopford Building, Oxford Rd, Manchester M13 9PT, England
Arch Gen Psychiatry 65:154-64. 2008b>Ketamine evokes psychosislike symptoms, and its primary action is to impair N-methyl-D-aspartate glutamate receptor neurotransmission, but it also induces secondary increases in glutamate release.
- The prevalence and natural history of urinary symptoms among recreational ketamine usersAdam R Winstock
Addiction CAG, South London and Maudsley NHS Foundation Trust St George s Hospital Medical School, London, UK
BJU Int 110:1762-6. 2012..the subject? and What does the study add? Case series have described lower urinary tract symptoms associated with ketamine use including severe pain, frequency, haematuria and dysuria...
- NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousnessTahir Hakami
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
PLoS ONE 4:e6755. 2009The psychotomimetics ketamine and MK-801, non-competitive NMDA receptor (NMDAr) antagonists, induce cognitive impairment and aggravate schizophrenia symptoms...
- A translational study of the effects of ketamine and pregabalin on temporal summation of experimental painLars Arendt-Nielsen
Center for Sensory Motor Interactions, Department of Health Science and Technology, Aalborg University, Denmark
Reg Anesth Pain Med 36:585-91. 2011..This preclinical and clinical translational study investigated the effect of ketamine and pregabalin on temporal summation (TS) and wind-up of wide dynamic range (WDR) neurons of nociceptive ..
- Effect of the addition of ketamine to morphine in patient-controlled analgesiaC J Murdoch
Stobhill Hospital, North Glasgow University Hospitals NHS Trust, UK
Anaesthesia 57:484-8. 2002..prospective study compared morphine (1 mg x m(-1)) with the combination of morphine (1 mg x m(-1)) and ketamine (0.75 mg x m(-1)) via a patient-controlled analgesia system (PCAS) for postoperative pain control...
- The effect of prolonged anesthesia with isoflurane, propofol, dexmedetomidine, or ketamine on neural cell proliferation in the adult ratAvery Tung
Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, USA
Anesth Analg 106:1772-7. 2008..To test this hypothesis, we investigated the effects of prolonged anesthesia with four different anesthetics on hippocampal cell proliferation in young and older rats...
- Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic painYoshinori Hayashi
Department of Aging Science and Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
J Neurosci 31:17370-82. 2011b>Ketamine is an important analgesia clinically used for both acute and chronic pain. The acute analgesic effects of ketamine are generally believed to be mediated by the inhibition of NMDA receptors in nociceptive neurons...
- Ketamine-induced oscillations in the motor circuit of the rat basal gangliaMaría Jesús Nicolás
Neurophysiology Laboratory, Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
PLoS ONE 6:e21814. 2011..b>Ketamine administration has been shown to cause an increase in gamma activity in cortical and subcortical structures, and ..
- Nefopam and ketamine comparably enhance postoperative analgesiaBarbara Kapfer
Department of Anesthesia, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, Boulogne 92100, France
Anesth Analg 100:169-74. 2005..We therefore tested the hypothesis that the administration of ketamine or nefopam to postoperative patients with pain only partly alleviated by morphine reduces the amount of ..
- Ketamine as a novel antidepressant: from synapse to behaviorJ W Murrough
Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
Clin Pharmacol Ther 91:303-9. 2012Recent reports of a rapid antidepressant effect of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, even in treatment-resistant populations, have spurred translational therapeutic and neuroscience research aimed at ..
- Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levelsB K Goulart
Laboratory of Molecular Neuropharmacology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
Neuroscience 167:969-73. 2010The non-competitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist ketamine has been shown to produce cognitive deficits. However, the effects of ketamine on the consolidation phase of memory remain poorly characterized...
- N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophreniaR S Ehrlichman
Stanley Center for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroscience 158:705-12. 2009..5 Hz) and gamma (31-61 Hz) bands in the context of N-methyl-d-aspartic acid receptor (NMDAR) hypofunction and dopaminergic hyperactivity, both of which are thought to serve as pharmacological models of schizophrenia...
- A comparison of ketamine and lidocaine spray with propofol for the insertion of laryngeal mask airway in children: a double-blinded randomized trialJae Hyon Bahk
Department of Anesthesiology and Clinical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Korea
Anesth Analg 95:1586-9, table of contents. 2002..In this double-blinded, randomized study, we examined whether pretreatment with lidocaine spray, ketamine anesthesia, and LMA insertion could be used as airway management that could maintain spontaneous breathing in ..
- Effects of anesthetics on systemic hemodynamics in miceBen J A Janssen
Dept of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, Universiteit Maastricht, PO Box 616, Maastricht 6200 MD, The Netherlands
Am J Physiol Heart Circ Physiol 287:H1618-24. 2004..General anesthesia was then induced in these mice using isoflurane (Iso), urethane, pentobarbital sodium, or ketamine-xylazine (K-X)...
- Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humansWolfgang Koppert
Department of Anesthesiology, University Clinic of Erlangen, Germany
Anesthesiology 99:152-9. 2003..to determine the time course of analgesic and hyperalgesic effects of the mu-receptor agonist remifentanil alone or in combination with the N-methyl-D-aspartate-receptor antagonist S-ketamine or the alpha(2)-receptor agonist clonidine.
- Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgeryPatricia Lavand'homme
Department of Anesthesiology, St Luc Hospital, Universite Catholique de Louvain, Brussels, Belgium
Anesthesiology 103:813-20. 2005..The current study assessed the role and timing of epidural analgesia in this context...
- Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review)R F Bell
Pain Clinic, Department of Anaesthesia and Intensive Care, Haukeland University Hospital and Department of Surgical Sciences, University of Bergen, Norway
Acta Anaesthesiol Scand 49:1405-28. 2005..Adjuvant treatment with an inexpensive opioid-sparing drug such as ketamine may be of value in giving better analgesia with fewer adverse effects...
- Ketamine disrupts θ modulation of γ in a computer model of hippocampusSamuel A Neymotin
State University of New York Downstate New York University Poly Joint Biomedical Engineering Program, Brooklyn, New York 11201, USA
J Neurosci 31:11733-43. 2011..gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic...
- Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorderNancy Diazgranados
National Institute of Mental Health, and Department of Human Health Services, Bethesda, Maryland, USA
J Clin Psychiatry 71:1605-11. 2010..Little research has been done on pharmacologic interventions that could address this problem. Ketamine, an N-methyl-D-asparate antagonist, has been reported to have antidepressant effects within hours...
- A systematic review of intravenous ketamine for postoperative analgesiaKevin Laskowski
Department of Anesthesiology, Perioperative Medicine and Pain Management, College of Medicine, University of Saskatchewan, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK S7N 0W8, Canada
Can J Anaesth 58:911-23. 2011Perioperative intravenous ketamine may be a useful addition in pain management regimens. Previous systematic reviews have included all methods of ketamine administration, and heterogeneity between studies has been substantial...
- Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamineVincent Joly
Department of Anesthesia, Institut National de la Santé et de la Recherche Médicale INSERM E 332, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, France
Anesthesiology 103:147-55. 2005..study tested the hypotheses that increased pain sensitivity assessed by periincisional allodynia and hyperalgesia can occur after relatively large-dose intraoperative remifentanil and that small-dose ketamine prevents this hyperalgesia.
- Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depressionMarije aan het Rot
Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York
Biol Psychiatry 67:139-45. 2010A single subanesthetic (intravenous) IV dose of ketamine might have rapid but transient antidepressant effects in patients with treatment-resistant depression (TRD)...
- Successful small intestine colonization of adult mice by Vibrio cholerae requires ketamine anesthesia and accessory toxinsVerena Olivier
Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
PLoS ONE 4:e7352. 2009..Successful colonization was found to depend upon anesthesia with ketamine-xylazine and neutralization of stomach acid with sodium bicarbonate, but not streptomycin treatment...
- Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamineXiaoping Gu
Department of Anesthesiology, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, Jiangsu Province, China
Mol Pain 5:76. 2009..of postoperative pain to investigate the role of tyrosine phosphorylation of NMDA receptor 2B (NR2B) subunit in spinal cord in the postoperative hyperalgesia induced by remifentanil and the intervention of pretreatment with ketamine.
- Glutamatergic modulators: the future of treating mood disorders?Carlos Zarate
Experimental Therapeutics and Pathophysiology Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Harv Rev Psychiatry 18:293-303. 2010..In addition to evidence confirming the role of the glutamatergic modulators riluzole and ketamine as proof-of-concept agents in this system, trials with diverse glutamatergic modulators are under way...
- Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive functionJohn H Krystal
Department of Psychiatry and Division of Biostatistics, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn 06516, USA
Arch Gen Psychiatry 62:985-94. 2005In healthy individuals, ketamine hydrochloride and amphetamine sulfate produce cognitive, behavioral, and subjective effects resembling endogenous psychoses...
- Differential effects of cocaine and ketamine on time estimation: implications for neurobiological models of interval timingRuey Kuang Cheng
Department of Psychology and Neuroscience, Genome Sciences Research Building II 3rd Floor, Duke University, Durham, NC 27708, USA
Pharmacol Biochem Behav 85:114-22. 2006The present experiment examined the effects of cocaine (0.0 and 15 mg/kg, i.p.) and ketamine (0.0, 10.0 and 15 mg/kg, i.p.) on timing behavior using a 12-s differential reinforcement of low rates (DRL) procedure and a 2- vs...
- Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trialPatricia Jabre
Samu 93 Equipe d accueil EA 3409, Hopital Avicenne, AP HP, Universite Paris 13, Bobigny, France
Lancet 374:293-300. 2009..We compared early and 28-day morbidity after a single dose of etomidate or ketamine used for emergency endotracheal intubation of critically ill patients.
- Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic reviewKathirvel Subramaniam
Department of Anesthesiology, Critical Care and Pain Management, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Anesth Analg 99:482-95, table of contents. 2004Animal studies on ketamine and opioid tolerance have shown promising results. Clinical trials have been contradictory. We performed a systematic review of randomized, double-blind clinical trials of ketamine added to opioid analgesia...
- Exploring the impact of ketamine on the experience of illusory body ownershipHannah L Morgan
Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Downing Site, United Kingdom
Biol Psychiatry 69:35-41. 2011..This illusion is stronger in schizophrenia. Given the evidence that ketamine, a noncompetitive N-methyl-D-aspartate antagonist reproduces symptoms of schizophrenia, we sought to determine ..
- Ketamine modulates theta and gamma oscillationsMaciej T Lazarewicz
Neuroengineering Laboratory, Department of Bioengineering, University of Pennsylvania, Philadelphia 19104, USA
J Cogn Neurosci 22:1452-64. 2010b>Ketamine, an N-methyl-D-aspartate (NMDA) receptor glutamatergic antagonist, has been studied as a model of schizophrenia when applied in subanesthetic doses...
- Ketamine and the next generation of antidepressants with a rapid onset of actionRodrigo Machado-Vieira
Experimental Therapeutics Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland, USA
Pharmacol Ther 123:143-50. 2009..In this context, the N-methyl-D-aspartate (NMDA) antagonist ketamine has consistently shown antidepressant effects within a few hours of its administration...
- Psychological effects of ketamine in healthy volunteers. Phenomenological studyE Pomarol-Clotet
Benito Menni CASM, Barcelona, Spain
Br J Psychiatry 189:173-9. 2006The psychosis-inducing effect of ketamine is important evidence supporting the glutamate hypothesis of schizophrenia. However, the symptoms the drug produces have not been described systematically.
- Perioperative small-dose S(+)-ketamine has no incremental beneficial effects on postoperative pain when standard-practice opioid infusions are usedWolfgang Jaksch
Department of Anesthesiology and Intensive Care Medicine, Ludwig Boltzmann Institute of Experimental Anesthesiology and Research in Intensive Care Medicine, Wilhelminenspital, Vienna, Austria
Anesth Analg 94:981-6, table of contents. 2002Several studies report that when small-dose racemic ketamine, an N-methyl-D-aspartate receptor antagonist, is administered perioperatively, opioid consumption is reduced postoperatively...
- The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in ratsKristin Engelhard
Klinik fur Anaesthesiologie, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
Anesth Analg 96:524-31, table of contents. 2003In this study, we investigated whether the neuroprotection previously seen with dexmedetomidine or S(+)-ketamine involves regulation of proapoptotic (Bax and p53) and antiapoptotic (Bcl-2 and Mdm-2) proteins...
- Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in cultureCheng Wang
Division of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079 0502, USA
Toxicol Sci 91:192-201. 2006b>Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is used as a general pediatric anesthetic. Recent data suggest that anesthetic drugs may cause neurodegeneration during development...
- The role of ketamine in pain managementE Visser
Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, and University of Western Australia, School of Medicine and Pharmacology, Perth, WA 6847, Australia
Biomed Pharmacother 60:341-8. 2006b>Ketamine is a dissociative anaesthetic; its mechanism of action is primarily an antagonism of the N-methyl-D-aspartate (NMDA) receptor...
- Ketamine and postoperative pain--a quantitative systematic review of randomised trialsNadia Elia
EBCAP Institute Evidence Based Critical care, Anaesthesia and Pain treatment, Division of Anaesthesiology, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Pain 113:61-70. 2005b>Ketamine, an N-methyl-D-aspartate receptor antagonist, is known to be analgesic and to induce psychomimetic effects. Benefits and risks of ketamine for the control of postoperative pain are not well understood...
- Ketamine increases human motor cortex excitability to transcranial magnetic stimulationV Di Lazzaro
Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, 00168 Rome, Italy
J Physiol 547:485-96. 2003Subanaesthetic doses of the N-methyl-D-aspartate (NMDA) antagonist ketamine have been shown to determine a dual modulating effect on glutamatergic transmission in experimental animals, blocking NMDA receptor activity and enhancing non-..
- Impact of ketamine on neuronal network dynamics: translational modeling of schizophrenia-relevant deficitsBernat Kocsis
Laboratory of Neurophysiology, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
CNS Neurosci Ther 19:437-47. 2013Subanesthetic doses of the psychomimetic, ketamine, have been used for many years to elicit behavioral effects reminiscent of schizophrenia in both healthy humans and in animal models of the disease...
- Effect of intravenous lidocaine and ketamine on the minimum alveolar concentration of isoflurane in goatsTom Doherty
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
Vet Anaesth Analg 34:125-31. 2007To evaluate the effects of i.v. lidocaine (L) and ketamine (K), alone and in combination (LK), on the minimum alveolar concentration (MAC) of isoflurane (ISO) in goats.
- The anti-inflammatory effects of ketamine: state of the artS Loix
Intensive Care Unit, Jolimont Hospital, La Louvibre, Belgium
Acta Anaesthesiol Belg 62:47-58. 2011..Among these drugs, ketamine seems to have a significant positive effect on the regulation of inflammation...
- Ketamine effects on the urogenital system--changes in the urinary bladder and sperm motilitySijie Tan
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Microsc Res Tech 74:1192-8. 2011Different doses of ketamine (10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg, and 60 mg/kg) were injected i.p. (I.P.), respectively, to male ICR mice to determine the optimal dosage for chronic administration. At and above 40 mg/kg I.P...
- Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS studyLaura M Rowland
Department of Psychiatry, MIND Imaging Center, University of New Mexico, USA
Am J Psychiatry 162:394-6. 2005..The authors' goal was to test in humans the hypothesis that N-methyl-d-aspartate receptor (NMDAR) antagonism results in increased cortical glutamate activity, as proposed by the NMDAR hypofunction model of schizophrenia...
- Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-upEvgeny Krupitsky
St Petersburg Research Center of Addictions and Psychopharmacology, Novo Deviatkino 19 1, Leningrad Region 188661, Russia
J Subst Abuse Treat 23:273-83. 2002Seventy detoxified heroin-addicted patients were randomly assigned to one of two groups receiving ketamine psychotherapy (KPT) involving two different doses of ketamine...
- Remifentanil in combination with ketamine versus remifentanil in spinal fusion surgery--a double blind studyB A Hadi
Faculty of Pharmacy, Philadelphia University, 2Arab Medical Center, Amman, Jordan
Int J Clin Pharmacol Ther 48:542-8. 2010..This study is aimed at conducting a program for two different anesthetic methods used during a spinal fusion surgery to ensure better intra-operative hemodynamic stability and post-operative pain control...
- Recreational ketamine: from pleasure to painDan Wood
Department of Urology, University College London Hospitals, UK
BJU Int 107:1881-4. 2011b>Ketamine has become increasingly recognized as a drug of recreational use. Individuals using significant amounts have developed symptoms including a small painful bladder, ureteric obstruction, papillary necrosis and hepatic dysfunction...
- Dual involvements of cyclooxygenase and nitric oxide synthase expressions in ketamine-induced ulcerative cystitis in rat bladderShu Mien Chuang
Yuh Ing Junior College of Health Care and Management, Kaohsiung, Taiwan
Neurourol Urodyn 32:1137-43. 2013..The aims of the present study were to investigate voiding patterns, tissue constituents and the expressions of cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS) involved in ketamine-induced ulcerative cystitis in rat urinary bladder.
- Reversal of ketamine-induced working memory impairments by the GABAAalpha2/3 agonist TPA023Stacy A Castner
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
Biol Psychiatry 67:998-1001. 2010b>Ketamine has been used to model cognitive and behavioral symptoms of schizophrenia...
- Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamineGiacomo Salvadore
Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
Neuropsychopharmacology 35:1415-22. 2010..treatment responders from non-responders to various pharmacological antidepressant interventions, including ketamine, an N-methyl-D-aspartate receptor antagonist...
- The influence of fentanyl vs. s-ketamine on intubating conditions during induction of anaesthesia with etomidate and rocuroniumT Ledowski
Department of Anaesthesiology and Intensive Care Medicine, Hospital of the Christian-Albrechts-University, Schwanenweg 21, D24105 Kiel, Germany
Eur J Anaesthesiol 18:519-23. 2001BACKGROUND AND OBJECTIVE: In the present study, we investigated the combination of etomidate and s-ketamine with regard to its suitability for modified rapid-sequence induction using rocuronium for muscle relaxation...
- The psychotomimetic states inventory (PSI): measuring psychotic-type experiences from ketamine and cannabisOliver J Mason
Sub Department of Clinical Health Psychology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Schizophr Res 103:138-42. 2008This study reports a new measure of psychotomimetic states in the context of cannabis and ketamine use...
- A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: microPET Imaging using 18F-annexin VXuan Zhang
Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
Toxicol Sci 111:355-61. 2009It has been reported that suppression of N-methyl-D-aspartate (NMDA) receptor function by ketamine may trigger apoptosis of neurons when given repeatedly during the brain growth spurt period...
- The effects of ketamine-xylazine anesthesia on cerebral blood flow and oxygenation observed using nuclear magnetic resonance perfusion imaging and electron paramagnetic resonance oximetryH Lei
NMR Research Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
Brain Res 913:174-9. 2001b>Ketamine-xylazine is a commonly used anesthetic for laboratory rats...
- Glutamatergic approaches in major depressive disorder: focus on ketamine, memantine and riluzoleR T Owen
Drugs Today (Barc) 48:469-78. 2012..The NMDA receptor antagonist ketamine has been investigated in various mood disorders, especially major depressive disorder (MDD)...
- Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapyT Yamamoto
Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
Pain 72:5-12. 1997..characteristics of this intractable pain syndrome were investigated by the morphine, thiamylal and ketamine tests...
- Remodeling Neuronal Chromatin in Mouse Models for DepressionSchahram Akbarian; Fiscal Year: 2013..This finding is interesting because the non-specific NMDA receptor antagonist, ketamine, and the NR2B selective antagonist, CP101,606 elicit rapid antidepressant action in depressed subjects, including ..
- Mechanims of CNS Autonomic Regulation by EAJohn C Longhurst; Fiscal Year: 2013..The second involves reflex cardiovascular depression during mild gastric distension in ketamine-xylazine anesthetized rats, which appears to inhibit the prevagal neurons in the NA and presympathetic neurons in ..
- The Antidepressant Action of Ketamine:Brain ChemistryMATE ISTVAN MILAK; Fiscal Year: 2013..Studies report that a single intravenous sub-anesthetic dose of ketamine (an NMDA receptor antagonist) can bring about full remission in hours, even in treatment-resistant MDD...
- Drug Discovery for Cognitive Impairment Associated with Drugs of AbuseAlvin V Terry; Fiscal Year: 2013..we have characterized reversible pharmacological models for impairments in working memory in monkeys utilizing ketamine (hallucinogen);nomifensine (cocaine/amphetamine-like activity);and amitriptyline (biogenic amine uptake inhibitor/..
- Anesthetic Action: Molecular Substrates &Neural MechanismsDouglas A Bayliss; Fiscal Year: 2013..Proposed experiments focus primarily on HCN1-mediated actions of ketamine, a dissociative anesthetic for which a robust decrease in hypnotic sensitivity was obtained in conventional HCN1 ..
- Effects of lithium on cellular signalingRichard S Jope; Fiscal Year: 2011..We will test if the rapid antidepressant effect of ketamine involves inhibition of GSK3, test if neurotrophins or inflammatory molecules are altered by GSK3 and associated ..
- Rational polytherapy in the treatment of cholinergic seizuresClaude G Wasterlain; Fiscal Year: 2013..2/ a NMDA receptor antagonist which could be non-specific (dizocilpine or ketamine) or NR2B subunit-preferring (R025-6981 or felbamate), and 3/ an anticonvulsant acting at a non-GABA site such as ..
- The rodent continuous performance task: Filling the vigilance translational gapJARED WILLIAM YOUNG; Fiscal Year: 2010..whether psychostimulants such as nicotine, amphetamine, and methylphenidate will improve performance and whether ketamine will impair vigilance performance, consistent with human CPT studies...
- Electrophysiological mapping of corticocollicular projections involved with tonotHUBERT HYUNGIL LIM; Fiscal Year: 2013..Furthermore, BF shifts within ICC have also shown to contribute to BF shifts within A1. Using ketamine-anesthetized guinea pigs, the proposed studies will investigate how electrical stimulation of different frequency ..
- Effects of lithium on cellular signalingRichard S Jope; Fiscal Year: 2013..We will test if the rapid antidepressant effect of ketamine involves inhibition of GSK3, test if neurotrophins or inflammatory molecules are altered by GSK3 and associated ..
- The role of spontaneous neurotransmission in synaptic plasticity and behaviorDevon C Crawford; Fiscal Year: 2013..and behavior, but prior work has implicated its inhibition in the fast-acting antidepressant effects of low-dose ketamine administration in treatment-resistant depression...
- RAPIDLY-ACTING TREATMENTS FOR TREATMENT-RESISTANT DEPRESSION (RAPID)Maurizio Fava; Fiscal Year: 2011..Over the last decade, a series of studies has demonstrated the ability of novel approaches [unreadable] including ketamine and sleep deprivation therapy [unreadable] to provide significant amelioration of symptoms within a few hours...
- The 5-HT theory of depression tested in a naturalistic model of 5-HT deficiencyMarc G Caron; Fiscal Year: 2013..Aim 2 will test whether antidepressant- like responses to SSRI and ketamine are affected by 5-HT deficiency...
- Dysregulation of glial glutamate transmission as a model of depressive illnessANITA JEAN BECHTHOLT GOMPF; Fiscal Year: 2011..suggest a causal link between glutamatergic function and the treatment of depression by demonstrating that ketamine, an antagonist at NMDA (glutamate) receptors, has antidepressant effects in humans and laboratory animals (Maeng ..
- Novel Interventions for Adults with Obsessive-Compulsive DisorderCarolyn I Rodriguez; Fiscal Year: 2013..Project #2: is a randomized trial of ketamine, a glutamate receptor antagonist, in drug free OCD patients who have failed prior SRI trials...
- Sex Differences in Ketamine Antidepressant EffectsYi Zhou; Fiscal Year: 2013..However, recent clinical studies have shown that a single low-dose injection of ketamine, an N-methyl d-aspartate receptor (NMDAR) antagonist, has rapid antidepressant effects that are observed within ..
- PATHOGENESIS OF RETT SYNDROMESAKKUBAI R NAIDU; Fiscal Year: 2010..Also, the effect of ketamine-induced blocking of glutamate receptors on dopamine release will be investigated...
- Delineating NMDA Receptor Hypofunctions Role in Schizophrenia PathophysiologyKAZUTOSHI NAKAZAWA; Fiscal Year: 2013DESCRIPTION (provided by applicant): NMDAR antagonists, including phencyclidine, ketamine and MK-801, induce a psychotic reaction in human subjects that resembles many of schizophrenia symptoms leading the NMDA receptor (NMDAR) ..
- Cellular Mechanisms of General Anesthetic Mediated NeurotoxicityDeborah J Culley; Fiscal Year: 2010..To test this hypothesis, we will use a few selected general anesthetic agents (ketamine, propofol, isoflurane) and a cell culture model that permits the maturity and differentiation state of the cells ..
- Antidepressants and Intracellular Signaling Linked to BDNFLisa M Monteggia; Fiscal Year: 2013..A rather surprising finding in the field of depression has been the demonstration that ketamine, an ionotropic glutamatergic n-methyl-daspartate (NMDA) receptor antagonist, has rapid and long-lasting ..
- Improving Psychiatric Interventions at the End of LifeScott A Irwin; Fiscal Year: 2012..Several other studies have been completed investigating ketamine for the rapid treatment of depression in hospice patients, as well as studies of cognitive impairments, hospice ..
- Drugs of Abuse and Memory SpanJOSEPH MARK GALIZIO; Fiscal Year: 2012..using the span procedure including benzodiazepines (chlordiazepoxide, midazolam), NMDA antagonists (dizocilpine, ketamine), opiates (morphine), psychostimulants (methylphenidate, methamphetamine, MDMA), and an anticholinergic ..
- Long-term neurobehavioral effects of ketamine exposure in adolescent miceSteven J Siegel; Fiscal Year: 2012..follows the Principal Investigator's Phase I application entitled, Evoked potentials and vulnerability to ketamine in mice (5-R21-DA-017082-02)...
- An NMDA Glycine Site Antagonist for the Treatment of Major Depressive DisorderRobert Schwarcz; Fiscal Year: 2013..A recent exciting development is the finding that ketamine, which is widely used as an anesthetic in surgical settings, has efficacy as a rapidly acting antidepressant in ..
- Circumventing physiological consequences of drug abuseAnthony A Grace; Fiscal Year: 2013..neuron activity can be reversed by inactivating the amygdala or by administering the NMDA channel blocker ketamine;a drug that is known to be a rapidly acting antidepressant...
- THE BEHAVIORAL PHARMACOLOGY OF PHENCYCLIDINERobert L Balster; Fiscal Year: 2010The abuse of phencyclidine (PCP) and ketamine remain important public health problems...
- Anesthesia Toxicity in Neonatal Primate BrainJohn W Olney; Fiscal Year: 2013..and oligodendrocytes) induced by clinically relevant exposure to each of three anesthetic drugs (isoflurane, ketamine, propofol)...
- Imaging the antipsychotic actions of metabotropic glutamate receptor-2 activatorsJohn C Gore; Fiscal Year: 2013..suggest that mGlu2/3 activation is effective in improving both positive and negative symptoms and a study in ketamine-induced working memory deficits in human subjects suggests that cognition can be improved, too...
- Sensitive and Treatable Periods of Brain-Redox Imbalance in SchizophreniaSusan B Powell; Fiscal Year: 2013..e. perinatal exposure to the NMDA receptor antagonist ketamine (pNM model), and social isolation rearing (SI model)...
- Mechanisms underlying fast-onset antidepressant effects of 5-HT2C antagonists - RStephanie C Dulawa; Fiscal Year: 2013..None of these, including the noncompetitive NMDA antagonist ketamine, are approved for clinical use due to adverse side effects...
- Brief Potent Glutamatergic Modulation: Applications for Cocaine DependenceElias Dakwar; Fiscal Year: 2013..Specifically, this proposal will focus on treating cocaine dependence with sub-anesthetic infusions of ketamine, a high-affinity non-competitive N- methyl-D-aspartate receptor (NMDAR) antagonist, which has recently emerged as ..
- Functional MRI Studies of Emotion in Depression and Rapid Antidepressant ResponseJAMES WARREN MURROUGH; Fiscal Year: 2013..e., experience TRD). Recent findings of rapid and robust antidepressant effects of the anesthetic agent ketamine, a N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, present a unique opportunity to test hypotheses ..
- Examining The Effect Of Ketamine On Glutamate/Glutamine CyclingChadi Abdallah; Fiscal Year: 2013..a pharmaco-imaging paradigm to study the mechanisms underlying the antidepressant and psychotomimetic effects of ketamine. Ketamine is an anesthetic agent, recently found to exert a rapid and potent antidepressant effect in severely ..
- Characterizing Cognitive Impairment in Schizophrenia via Computational Modeling aAlan Anticevic; Fiscal Year: 2013..of schizophrenia that perturbs the precise mechanism in healthy volunteers, namely transient NMDA antagonism via ketamine;iii) to relate these pharmacological results to deficits observed in patients using behavior and functional ..
- Role of p70S6 kinase in the synaptic and behavioral deficits induced by stressJason Dwyer; Fiscal Year: 2013..Recent evidence has identified that the drug ketamine produces rapid and robust effects in depressed patients (Berman et al., 2000;Zarate et al...
- Role of mTOR and Synaptogenesis in the Actions of Rapid-Acting AntidepressantsRonald S Duman; Fiscal Year: 2013..Recent studies demonstrate that a single low dose of ketamine, a glutamate-NMDA receptor antagonist, produces rapid antidepressant actions (2 hr) that last for up to 7 days in ..
- Ketamine vs Midazolam: Testing Rapid Relief of Suicide Risk in DepressionMichael F Grunebaum; Fiscal Year: 2013..suicidal ideation, in as little as one hour, in depressed patients after intravenous infusion of sub-anesthetic ketamine, a glutamate antagonist and commonly used anesthetic...
- GABAergic Control of Depression Related Brain StatesBernhard Luscher; Fiscal Year: 2013..Treatment of mutant cultures with ketamine results in reversal of these deficits...
- Identifying Virtual Reality Analgesia Mechanisms by Pharmacologic ManipulationSam R Sharar; Fiscal Year: 2013..the comparative and additive effects of immersive VR and N-methyl-D-aspartate (NMDA) antagonism with low- dose ketamine (at a sub-anesthetic dose devoid of hallucinatory effects, but associated with analgesia, expansive mood, and ..
- Translational Neuroscience Optimization of GlyT1 InhibitorJohn H Krystal; Fiscal Year: 2013..facilitation of NMDAR function;we will determine whether PF-03463275 produces dose-related attenuation of the ketamine-induced disruption in prefrontal cortical BOLD activation related to working memory...
- Optimization of IV Ketamine for Treatment Resistant Major DepressionSanjay J Mathew; Fiscal Year: 2012..b>Ketamine, a high-affinity NMDA glutamate receptor antagonist, is an anesthetic and analgesic medication commonly used in ..
- Neurotoxicity of NMDA Receptor AntagonistsFrank Sharp; Fiscal Year: 2005..applicant?s abstract): The non-competitive NMDA receptor antagonists, including phencyclidine (PCP, angel dust), ketamine (Special K), and dizocilpine (MK-801), have been used as anesthetics, protect against experimental stroke, are ..
- Patterns of Drug Use and Abuse in the Brazilian Rave CultureJames Inciardi; Fiscal Year: 2009..S. the most popular of the club drugs have been MDMA (ecstasy), GHB, ketamine, LSD, methamphetamine, and a few prescription drugs, such as dextroamphetamine and methylphenidate...
- The Effect of Glutamatergic Modulation on Cocaine Self-AdministrationElias Dakwar; Fiscal Year: 2013..Our preliminary investigations with ketamine, a glutamatergic modulator with potent prefrontal effects, suggest that it represents a promising Candidate...
- Tumor NMR Images are Affected by AnestheticNatarajan Raghunand; Fiscal Year: 2006..effects, and resulting effects upon DCE-MRI images, using three commonly used anesthetic protocols: ketamine/xylazine/acepromazine, pentobarbital, and isoflurane, and one customized injectable anesthetic protocol: ..
- Mentored Patient-Oriented Research Career Development AwKelly Young; Fiscal Year: 2004..as a measure of the long-term effects of painful experiences; and 4) to test a pharmacological (intramuscular ketamine and midazolam) and a behavioral (blowing on a party blower) intervention for reducing the pain and stress ..
- Regulation of Protein Translation and Depression by Cortical NMDA Receptors.Benjamin Hall; Fiscal Year: 2013DESCRIPTION (provided by applicant): A single, low dose of the n-methyl d-aspartate receptor (NMDAR) antagonist ketamine produces rapid anti-depressant actions in treatment-resistant depressed patients...
- Evoked potentials and vulnerability to ketamine in mice.Steven Siegel; Fiscal Year: 2004..Background: Abuse of NMDA receptor antagonists, such as ketamine and phencyclidine (PCP), has been recognized for many years...
- MOLECULAR STUDIES OF ANESTHETIC-MUSCARINIC INTERACTIONSMarcel Durieux; Fiscal Year: 1999..anesthetics have been shown to inhibit muscarinic signaling, and some non-volatile anesthetic agents, such as ketamine and althesin, similarly appear to affect the system...
- GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTSDEEPAK D SOUZA; Fiscal Year: 2002..The noncompetitive NMDA receptor antagonist ketamine, induces symptoms in healthy individuals resembling several aspects of schizophrenia...
- Impulsivity and Demand for Drug in Rhesus MonkeysGAIL D WINGER; Fiscal Year: 2012..g., ketamine or short-acting barbiturates)...
- QTLS UNDERLYING MOLECULAR ACTION OF GENERAL ANESTHETICSThomas Johnson; Fiscal Year: 2000..QTLs are to be identified for other general anesthetics (isoflurane, enflurane, etomidate, halothane, and ketamine) using both LS x SS recombinant inbred strains and F2 mice...
- MGT SVCS/CONTRACT &PROCUREMENT SUPX X; Fiscal Year: 2013..The study shall be a double-blind, placebo-controlled study of the acute efficacy of ketamine for the treatment of adults with treatment-resistant depression...
- Trends in Club Drug UseChristopher Krebs; Fiscal Year: 2002..lysergic acid diethylamide (LSD), methylene-dioxy-methamphetamine (MDMA or Ecstasy), gamma-hydroxybutyrate (GHB), Ketamine, Rohypnol, methamphetamine, and psilocybin, are gaining in popularity, users are getting younger, and serious ..
- HIV RISK AND KETAMINE INJECTION AMONG HIGH RISK YOUTHSTEPHEN LANKENAU; Fiscal Year: 2001..adapted from the applicant's abstract): "Club drugs," a relatively new category of illicit drugs that includes ketamine, MDMA (ecstasy), GHB, and methamphetamine, have become increasingly common across a variety of subpopulations...
- Club drug use/sexual risk-taking among Latino/other MSMJOHN ECHEVERRY; Fiscal Year: 2007..properties, such as methamphetamine (crystal meth), 3-4 methylenedioxymethamphetamine (MDMA, or Ecstasy), ketamine (Special K), gamma hydroxybutyrate (GHB), and volatile nitrites (poppers)...
- DEVELOPMENT OF TRANSNASAL KETAMINE FOR BREAKTHROUGH PAINFRED MERMELESTEIN; Fiscal Year: 2000..abstract): The objectives of this proposal are to determine the safety and analgesic efficacy of transnasal ketamine in a Phase I clinical study as the first step towards FDA approval and commercialization...
- Youth, Technology, and the Proliferation of Drug UseDANIEL MURGUIA; Fiscal Year: 2002..MDMA (ecstasy), Lysergic Acid Diethylamide (LSD), Rohypnol, Methamphetamine, Ketamine, and Gammahydroxybutyrate (GBH) are substances generally labeled "club drugs...
- Abused NMDA Antagonists: Effects on Cortical DevelopmentMary Wilson; Fiscal Year: 2004This R21 application evaluates the hypothesis that the abused NMDA antagonists ketamine and dextromethorphan, by altering the function and expression of glutamate receptors, may have detrimental effects on the development of neocortex...
- NEUROPHARMACOLOGIC CHALLENGES IN DEMENTIANorman Foster; Fiscal Year: 1992..acetylcholine and glutamate upon cognition in dementia, we will investigate the cognitive effects of intravenous ketamine, a glutaminergic antagonist, and scopolamine, a cholinergic antagonist, in these disorders...
- KAINATE RECEPTOR ANTAGONISTS TO TREAT NEUROPATHIC PAINMARIA MACCECCHINI; Fiscal Year: 1999..Such a therapeutic agent would fulfill a tremendous unmet need since opiates and ketamine (by continuous i.v. infusion) are the only available compounds that can alleviate neuropathic pain...
- HIV RISK AND CLUB DRUGS AMONG MSM--A TWO CITY COMPARISONPatricia Case; Fiscal Year: 2002..and inhaled nitrites, as well as a number of relatively new and as yet unexamined substances such as ketamine and MDMA...
- PCP AND EXTRACELLULAR DOPAMINE IN BRAINDIANA JAUCH; Fiscal Year: 1993..psychosis circuit" will be examined by 2-deoxyglucose (2DG) autoradiography in rats given the PCP agonist ketamine or CPP, a competitive NMDA antagonist, and by use of positron emission tomography (PET) scanning in ..
- Norketamine for Treatment of PainJOSEPH HOLTMAN; Fiscal Year: 2003..b>Ketamine, a clinically available nonselective NMDA receptor antagonist, has been used parenterally for pain...