ketamine

Summary

Summary: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.

Top Publications

  1. ncbi Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia
    D Umbricht
    Psychiatric University Hospital, Department of Research, PO Box 68, Zurich 8029, Switzerland
    Arch Gen Psychiatry 57:1139-47. 2000
  2. pmc mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
    Nanxin Li
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Science 329:959-64. 2010
  3. ncbi A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    Carlos A Zarate
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:856-64. 2006
  4. pmc Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
    Nanxin Li
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 69:754-61. 2011
  5. ncbi Synaptic mechanisms underlying rapid antidepressant action of ketamine
    Ege T Kavalali
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Psychiatry 169:1150-6. 2012
  6. pmc Signaling pathways underlying the rapid antidepressant actions of ketamine
    Ronald S Duman
    Departments of Psychiatry and Neurobiology, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Neuropharmacology 62:35-41. 2012
  7. ncbi Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    Sungho Maeng
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Biol Psychiatry 63:349-52. 2008
  8. pmc GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects
    Jeffrey Burgdorf
    Department of Biomedical Engineering, Falk Center for Molecular Therapeutics, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, IL 60201, USA
    Neuropsychopharmacology 38:729-42. 2013
  9. ncbi Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression
    Hiroyuki Koike
    Discovery Pharmacology, Molecular Function and Pharmacology Laboratories, Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Kita ku, Saitama, Saitama 331 9530, Japan
    Behav Brain Res 224:107-11. 2011
  10. pmc Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex
    Rong Jian Liu
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 71:996-1005. 2012

Detail Information

Publications360 found, 100 shown here

  1. ncbi Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia
    D Umbricht
    Psychiatric University Hospital, Department of Research, PO Box 68, Zurich 8029, Switzerland
    Arch Gen Psychiatry 57:1139-47. 2000
    ..In this study, effects of the NMDAR antagonists ketamine on MMN generation and AX-CPT performance were investigated in healthy volunteers to test the hypothesis that ..
  2. pmc mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
    Nanxin Li
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Science 329:959-64. 2010
    The rapid antidepressant response after ketamine administration in treatment-resistant depressed patients suggests a possible new approach for treating mood disorders compared to the weeks or months required for standard medications...
  3. ncbi A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    Carlos A Zarate
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 63:856-64. 2006
    ..Converging lines of evidence suggest the role of the glutamatergic system in the pathophysiology and treatment of mood disorders...
  4. pmc Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
    Nanxin Li
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 69:754-61. 2011
    ....
  5. ncbi Synaptic mechanisms underlying rapid antidepressant action of ketamine
    Ege T Kavalali
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Psychiatry 169:1150-6. 2012
    Recent clinical studies have demonstrated that a single subpsychotomimetic dose of ketamine, an ionotropic glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonist, produces a rapid antidepressant response in patients with major ..
  6. pmc Signaling pathways underlying the rapid antidepressant actions of ketamine
    Ronald S Duman
    Departments of Psychiatry and Neurobiology, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Neuropharmacology 62:35-41. 2012
    ..Recent clinical studies have demonstrated that ketamine, an NMDA receptor antagonist produces a rapid antidepressant response (within hours) and is effective in ..
  7. ncbi Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    Sungho Maeng
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Biol Psychiatry 63:349-52. 2008
    b>Ketamine exerts a robust, rapid, and relatively sustained antidepressant effect in patients with major depression...
  8. pmc GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects
    Jeffrey Burgdorf
    Department of Biomedical Engineering, Falk Center for Molecular Therapeutics, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, IL 60201, USA
    Neuropsychopharmacology 38:729-42. 2013
    Recent human clinical studies with the NMDA receptor (NMDAR) antagonist ketamine have revealed profound and long-lasting antidepressant effects with rapid onset in several clinical trials, but antidepressant effects were preceded by ..
  9. ncbi Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression
    Hiroyuki Koike
    Discovery Pharmacology, Molecular Function and Pharmacology Laboratories, Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Kita ku, Saitama, Saitama 331 9530, Japan
    Behav Brain Res 224:107-11. 2011
    ..In clinical studies, an N-methyl-d-aspartate receptor antagonist, ketamine, was shown to exert both rapid and sustained antidepressant effects in patients with treatment-resistant MDD...
  10. pmc Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex
    Rong Jian Liu
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 71:996-1005. 2012
    ..of BDNF messenger RNA, that loss-of-function Met allele mice would show synaptic deficits both at baseline and in response to ketamine, an N-methyl-D-aspartate antagonist that stimulates synaptogenesis in prefrontal cortex (PFC).
  11. ncbi Dexmedetomidine-ketamine combination mitigates acute lung injury in haemorrhagic shock rats
    Chen Hsien Yang
    Department of Anaesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
    Resuscitation 80:1204-10. 2009
    ..Dexmedetomidine and ketamine possess potent anti-inflammatory capacity...
  12. pmc Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment
    Miriam Kron
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 32:13860-72. 2012
    ..reduced Fos expression, as well as abnormal sensorimotor function, were reversed by the NMDA receptor antagonist ketamine. In light of recent findings that the default mode network is hypoactive in autism, our data raise the ..
  13. pmc Ketamine for treatment-resistant unipolar depression: current evidence
    Sanjay J Mathew
    Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    CNS Drugs 26:189-204. 2012
    ..literature on the potential rapid-onset antidepressant properties of the glutamate NMDA receptor antagonist ketamine, an established anaesthetic agent...
  14. ncbi Ketamine use: a review
    Celia J A Morgan
    Clinical Psychopharmacology Unit, Clinical Health Psychology, University College London, London, UK
    Addiction 107:27-38. 2012
    b>Ketamine remains an important medicine in both specialist anaesthesia and aspects of pain management. At the same time, its use as a recreational drug has spread in many parts of the world during the past few years...
  15. ncbi Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: linking cognition, brain activity, and psychosis
    Philip R Corlett
    Brain Mapping Unit, Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, England
    Arch Gen Psychiatry 63:611-21. 2006
    ..Establishing a neurobiological account of delusion formation that links cognitive processes, brain activity, and symptoms is important to furthering our understanding of psychosis...
  16. ncbi Ketamine disrupts theta synchrony across the septotemporal axis of the CA1 region of hippocampus
    James R Hinman
    Department of Psychology, University of Connecticut, Storrs, Connecticut 06269 1020, USA
    J Neurophysiol 109:570-9. 2013
    ..b>Ketamine is an N-methyl-D-aspartate (NMDA) antagonist that can decrease theta power...
  17. pmc Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain
    Xiao peng Mei
    Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi an, PR China
    J Neuroinflammation 8:6. 2011
    ..previously reported that inhibition of astrocytic activation contributes to the analgesic effects of intrathecal ketamine on spinal nerve ligation (SNL)-induced neuropathic pain. However, the underlying mechanisms are still unclear...
  18. ncbi Effect of three types of mixed anesthetic agents alternate to ketamine in mice
    Sumiko Kawai
    Department of Laboratory Animal Medicine, Osaka University, Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Exp Anim 60:481-7. 2011
    b>Ketamine is usually used for murine anesthesia in animal experiments with other anesthetics for its sedation and analgesic effects. However, ketamine was categorized as a narcotic drug in Japan on January 1, 2007...
  19. ncbi Quantifying the attenuation of the ketamine pharmacological magnetic resonance imaging response in humans: a validation using antipsychotic and glutamatergic agents
    O M Doyle
    King s College London, Department of Neuroimaging, Institute of Psychiatry, London, United Kingdom
    J Pharmacol Exp Ther 345:151-60. 2013
    b>Ketamine acts as an N-methyl-D-aspartate receptor antagonist and evokes psychotomimetic symptoms resembling schizophrenia in healthy humans...
  20. ncbi Test-retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteers
    S De Simoni
    King s College London, Department of Neuroimaging, Institute of Psychiatry PO89, De Crespigny Park, London SE5 8AF, UK
    Neuroimage 64:75-90. 2013
    ..b>Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, induces a strong phMRI response and represents a promising ..
  21. pmc Modeling ketamine effects on synaptic plasticity during the mismatch negativity
    Andre Schmidt
    University Hospital of Psychiatry, Neuropsychopharmacology and Brain Imaging
    Cereb Cortex 23:2394-406. 2013
    ..of mechanisms underlying the reduction of mismatch negativity (MMN) amplitudes under the NMDA-receptor antagonist ketamine. We applied dynamic causal modeling and Bayesian model selection to data from a recent ketamine study of the ..
  22. ncbi Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain
    Gislaine Z Réus
    Laboratorio de Neurociencias, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
    Behav Brain Res 221:166-71. 2011
    ..of synergistic interactions between antidepressant imipramine with the uncompetitive NMDA receptor antagonist ketamine. Wistar rats were acutely treated with ketamine (5 and 10mg/kg) and imipramine (10 and 20mg/kg) and then ..
  23. pmc Complex receptor mediation of acute ketamine application on in vitro gamma oscillations in mouse prefrontal cortex: modeling gamma band oscillation abnormalities in schizophrenia
    J M McNally
    Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, 940 Belmont Street, Research 151C, Brockton, MA 02301, USA
    Neuroscience 199:51-63. 2011
    ..For several decades, administration of sub-anesthetic levels of ketamine has provided the most comprehensive experimental model of Sz-symptoms...
  24. ncbi The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance
    Jean Paul Laulin
    Universite Bordeaux 1, France
    Anesth Analg 94:1263-9, table of contents. 2002
    ..We investigated postfentanyl morphine analgesic effects and the consequences of NMDA-receptor antagonist (ketamine) pretreatment. The rat nociceptive threshold was measured by the paw-pressure vocalization test...
  25. ncbi Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats
    Lêda S B Garcia
    Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pos Graduacao em Ciencias da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 33:450-5. 2009
    ..Additionally, studies have shown that ketamine induces antidepressant effects in humans as well as in rodents subjected to animal models of depression...
  26. pmc Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression
    Rebecca B Price
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Biol Psychiatry 66:522-6. 2009
    Intravenous ketamine has shown rapid antidepressant effects in early trials, making it a potentially attractive candidate for depressed patients at imminent risk of suicide...
  27. ncbi Ketamine "unlocks" the reduced clock-speed effects of cocaine following extended training: evidence for dopamine--glutamate interactions in timing and time perception
    Ruey Kuang Cheng
    Department of Psychology and Neuroscience, Duke University, 572 Research Drive, Genome Sciences Research Building II, Box 91050, Durham, NC 27708, USA
    Neurobiol Learn Mem 88:149-59. 2007
    ..Importantly, when co-administered with a behaviorally ineffective dose of ketamine (10mg/kg, ip) the ability of cocaine to modulate clock speed in rats receiving extended training was restored...
  28. ncbi Paradoxical reaction following intravenous midazolam premedication in pediatric patients - a randomized placebo controlled trial of ketamine for rapid tranquilization
    Mohammad Golparvar
    Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran
    Paediatr Anaesth 14:924-30. 2004
    ..determine the incidence of paradoxical reactions following intravenous midazolam premedication in pediatric patients and to compare the efficacy of extra doses of midazolam with low-dose intravenous ketamine to rapidly tranquillize them.
  29. pmc A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression
    Nancy Diazgranados
    Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Arch Gen Psychiatry 67:793-802. 2010
    ..Pharmacological strategies that produce rapid antidepressant effects-for instance, within a few hours or days-would have an enormous impact on patient care and public health...
  30. ncbi N-methyl d-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant gamma oscillations in the rat neocortex
    Didier Pinault
    INSERM U666, Physiopathologie Clinique et Expérimentale de la Schizophrénie, Faculte de Medecine, Strasbourg, France
    Biol Psychiatry 63:730-5. 2008
    Single subanesthetic doses of ketamine, a non-competitive NMDA receptor (NMDAr) antagonist, induce cognitive impairment, schizophreniform psychosis, hallucinations, and exacerbate schizophrenia symptoms...
  31. ncbi Effects of ketamine in normal and schizophrenic volunteers
    A C Lahti
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Neuropsychopharmacology 25:455-67. 2001
    This study evaluates the effects of ketamine on healthy and schizophrenic volunteers (SVs) in an effort to define the detailed behavioral effects of the drug in a psychosis model...
  32. ncbi Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal
    Martin S Angst
    Department of Anesthesia, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Pain 106:49-57. 2003
    ..infusion with the mu-opioid agonist remifentanil, and whether co-administration of the NMDA-receptor antagonist S-ketamine would prevent such hyperalgesia...
  33. pmc Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys
    M G Paule
    Division of Neurotoxicology, National Center for Toxicological Research FDA, 3900 NCTR Road, Jefferson, AR 72079 9502, USA
    Neurotoxicol Teratol 33:220-30. 2011
    Previously our laboratory has shown that ketamine exposure (24h of clinically relevant anesthesia) causes significant increases in neuronal cell death in perinatal rhesus monkeys...
  34. ncbi Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats
    Chih Lin Yang
    Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan
    J Surg Res 167:e273-81. 2011
    ..Dexmedetomidine and ketamine are two sedative agents with potent anti-inflammatory capacity...
  35. ncbi Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations
    T A Bowdle
    Department of Psychiatry, Harborview Medical Center, University of Washington, Seattle 98195, USA
    Anesthesiology 88:82-8. 1998
    b>Ketamine has been associated with a unique spectrum of subjective "psychedelic" effects in patients emerging from anesthesia. This study quantified these effects of ketamine and related them to steady-state plasma concentrations.
  36. ncbi A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department
    Gregory Luke Larkin
    Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT, USA
    Int J Neuropsychopharmacol 14:1127-31. 2011
    We examined the preliminary feasibility, tolerability and efficacy of single-dose, intravenous (i.v.) ketamine in depressed emergency department (ED) patients with suicide ideation (SI)...
  37. ncbi Neurotoxicity of subarachnoid preservative-free S(+)-ketamine in dogs
    Lyvia Maria R S Gomes
    Department of Anesthesiology and Pain, Federal University of Maranhao, Brazil
    Pain Physician 14:83-90. 2011
    Subarachnoid S(+)-ketamine is a matter of much debate as the results regarding its toxicity are contradictory.
  38. pmc Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairments
    Andre Schmidt
    Neuropsychopharmacology and Brain Imaging, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland
    Neuropsychopharmacology 37:865-75. 2012
    Psychotomimetics like the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine and the 5-hydroxytryptamine2A receptor (5-HT(2A)R) agonist psilocybin induce psychotic symptoms in healthy volunteers that resemble those of schizophrenia...
  39. ncbi Ketamine depresses toll-like receptor 3 signaling in spinal microglia in a rat model of neuropathic pain
    Xiao peng Mei
    Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi an, PR China
    Neurosignals 19:44-53. 2011
    ..In addition, ketamine application could suppress microglial activation in vitro, and ketamine could inhibit proinflammatory gene ..
  40. pmc Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action
    Milan Scheidegger
    Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
    PLoS ONE 7:e44799. 2012
    ..underscores the strong and rapid antidepressant properties of the glutamate-modulating NMDA receptor antagonist ketamine. Targeting the glutamatergic system might thus provide a novel molecular strategy for antidepressant treatment...
  41. pmc Ketamine for depression: where do we go from here?
    Marije aan het Rot
    Department of Psychology and School of Behavioral and Cognitive Neuroscience, University of Groningen, The Netherlands
    Biol Psychiatry 72:537-47. 2012
    Since publication of the first randomized controlled trial describing rapid antidepressant effects of ketamine, several reports have confirmed the potential utility of this dissociative anesthetic medication for treatment of major ..
  42. ncbi Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus
    Lêda S B Garcia
    Laboratorio de Neurociencias, Programa de Pos Graduacao em Ciencias da Saude, Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 88806 000 Criciuma, SC, Brazil
    Prog Neuropsychopharmacol Biol Psychiatry 32:140-4. 2008
    b>Ketamine is a non-competitive antagonist to the phencyclidine site of N-methyl-d-aspartate (NMDA) receptor. Clinical findings point to a rapid onset of action for ketamine on the treatment of major depression...
  43. ncbi Phenomenon of new drugs on the Internet: the case of ketamine derivative methoxetamine
    Ornella Corazza
    School of Pharmacy, University of Hertfordshire, Hatfield, UK
    Hum Psychopharmacol 27:145-9. 2012
    ..This is a dissociative drug related to ketamine, with a much longer duration of action and intensity of effects...
  44. pmc Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine
    Jianjun Pan
    Department of Anesthesiology, Biomedical Science Tower 3, 3501 Fifth Avenue, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    Structure 20:1463-9. 2012
    ..GLIC, a prokaryotic pLGIC, can be inhibited by anesthetics, including ketamine. The ketamine concentration leading to half-maximal inhibition of GLIC (58 μM) is comparable to that on ..
  45. ncbi Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass
    Judith A Hudetz
    Department of Anesthesiology, Medical College of Wisconsin and Clement J Zablocki Veterans Administration Medical Center, Milwaukee, WI, USA
    J Cardiothorac Vasc Anesth 23:651-7. 2009
    To determine if ketamine attenuates postoperative delirium concomitant with an anti-inflammatory effect in patients undergoing cardiac surgery using cardiopulmonary bypass.
  46. ncbi Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study
    J F William Deakin
    Neuroscience and Psychiatry Unit, The University of Manchester, G 907 Stopford Building, Oxford Rd, Manchester M13 9PT, England
    Arch Gen Psychiatry 65:154-64. 2008
    b>Ketamine evokes psychosislike symptoms, and its primary action is to impair N-methyl-D-aspartate glutamate receptor neurotransmission, but it also induces secondary increases in glutamate release.
  47. ncbi The prevalence and natural history of urinary symptoms among recreational ketamine users
    Adam R Winstock
    Addiction CAG, South London and Maudsley NHS Foundation Trust St George s Hospital Medical School, London, UK
    BJU Int 110:1762-6. 2012
    ..the subject? and What does the study add? Case series have described lower urinary tract symptoms associated with ketamine use including severe pain, frequency, haematuria and dysuria...
  48. pmc NMDA receptor hypofunction leads to generalized and persistent aberrant gamma oscillations independent of hyperlocomotion and the state of consciousness
    Tahir Hakami
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
    PLoS ONE 4:e6755. 2009
    The psychotomimetics ketamine and MK-801, non-competitive NMDA receptor (NMDAr) antagonists, induce cognitive impairment and aggravate schizophrenia symptoms...
  49. ncbi A translational study of the effects of ketamine and pregabalin on temporal summation of experimental pain
    Lars Arendt-Nielsen
    Center for Sensory Motor Interactions, Department of Health Science and Technology, Aalborg University, Denmark
    Reg Anesth Pain Med 36:585-91. 2011
    ..This preclinical and clinical translational study investigated the effect of ketamine and pregabalin on temporal summation (TS) and wind-up of wide dynamic range (WDR) neurons of nociceptive ..
  50. ncbi Effect of the addition of ketamine to morphine in patient-controlled analgesia
    C J Murdoch
    Stobhill Hospital, North Glasgow University Hospitals NHS Trust, UK
    Anaesthesia 57:484-8. 2002
    ..prospective study compared morphine (1 mg x m(-1)) with the combination of morphine (1 mg x m(-1)) and ketamine (0.75 mg x m(-1)) via a patient-controlled analgesia system (PCAS) for postoperative pain control...
  51. ncbi The effect of prolonged anesthesia with isoflurane, propofol, dexmedetomidine, or ketamine on neural cell proliferation in the adult rat
    Avery Tung
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, USA
    Anesth Analg 106:1772-7. 2008
    ..To test this hypothesis, we investigated the effects of prolonged anesthesia with four different anesthetics on hippocampal cell proliferation in young and older rats...
  52. ncbi Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain
    Yoshinori Hayashi
    Department of Aging Science and Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 31:17370-82. 2011
    b>Ketamine is an important analgesia clinically used for both acute and chronic pain. The acute analgesic effects of ketamine are generally believed to be mediated by the inhibition of NMDA receptors in nociceptive neurons...
  53. pmc Ketamine-induced oscillations in the motor circuit of the rat basal ganglia
    María Jesús Nicolás
    Neurophysiology Laboratory, Neurosciences Area, CIMA, University of Navarra, Pamplona, Spain
    PLoS ONE 6:e21814. 2011
    ..b>Ketamine administration has been shown to cause an increase in gamma activity in cortical and subcortical structures, and ..
  54. pmc Nefopam and ketamine comparably enhance postoperative analgesia
    Barbara Kapfer
    Department of Anesthesia, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, Boulogne 92100, France
    Anesth Analg 100:169-74. 2005
    ..We therefore tested the hypothesis that the administration of ketamine or nefopam to postoperative patients with pain only partly alleviated by morphine reduces the amount of ..
  55. pmc Ketamine as a novel antidepressant: from synapse to behavior
    J W Murrough
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Clin Pharmacol Ther 91:303-9. 2012
    Recent reports of a rapid antidepressant effect of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, even in treatment-resistant populations, have spurred translational therapeutic and neuroscience research aimed at ..
  56. ncbi Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels
    B K Goulart
    Laboratory of Molecular Neuropharmacology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neuroscience 167:969-73. 2010
    The non-competitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist ketamine has been shown to produce cognitive deficits. However, the effects of ketamine on the consolidation phase of memory remain poorly characterized...
  57. ncbi N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia
    R S Ehrlichman
    Stanley Center for Experimental Therapeutics in Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuroscience 158:705-12. 2009
    ..5 Hz) and gamma (31-61 Hz) bands in the context of N-methyl-d-aspartic acid receptor (NMDAR) hypofunction and dopaminergic hyperactivity, both of which are thought to serve as pharmacological models of schizophrenia...
  58. ncbi A comparison of ketamine and lidocaine spray with propofol for the insertion of laryngeal mask airway in children: a double-blinded randomized trial
    Jae Hyon Bahk
    Department of Anesthesiology and Clinical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Korea
    Anesth Analg 95:1586-9, table of contents. 2002
    ..In this double-blinded, randomized study, we examined whether pretreatment with lidocaine spray, ketamine anesthesia, and LMA insertion could be used as airway management that could maintain spontaneous breathing in ..
  59. ncbi Effects of anesthetics on systemic hemodynamics in mice
    Ben J A Janssen
    Dept of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, Universiteit Maastricht, PO Box 616, Maastricht 6200 MD, The Netherlands
    Am J Physiol Heart Circ Physiol 287:H1618-24. 2004
    ..General anesthesia was then induced in these mice using isoflurane (Iso), urethane, pentobarbital sodium, or ketamine-xylazine (K-X)...
  60. ncbi Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans
    Wolfgang Koppert
    Department of Anesthesiology, University Clinic of Erlangen, Germany
    Anesthesiology 99:152-9. 2003
    ..to determine the time course of analgesic and hyperalgesic effects of the mu-receptor agonist remifentanil alone or in combination with the N-methyl-D-aspartate-receptor antagonist S-ketamine or the alpha(2)-receptor agonist clonidine.
  61. ncbi Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery
    Patricia Lavand'homme
    Department of Anesthesiology, St Luc Hospital, Universite Catholique de Louvain, Brussels, Belgium
    Anesthesiology 103:813-20. 2005
    ..The current study assessed the role and timing of epidural analgesia in this context...
  62. ncbi Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review)
    R F Bell
    Pain Clinic, Department of Anaesthesia and Intensive Care, Haukeland University Hospital and Department of Surgical Sciences, University of Bergen, Norway
    Acta Anaesthesiol Scand 49:1405-28. 2005
    ..Adjuvant treatment with an inexpensive opioid-sparing drug such as ketamine may be of value in giving better analgesia with fewer adverse effects...
  63. pmc Ketamine disrupts θ modulation of γ in a computer model of hippocampus
    Samuel A Neymotin
    State University of New York Downstate New York University Poly Joint Biomedical Engineering Program, Brooklyn, New York 11201, USA
    J Neurosci 31:11733-43. 2011
    ..gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic...
  64. pmc Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder
    Nancy Diazgranados
    National Institute of Mental Health, and Department of Human Health Services, Bethesda, Maryland, USA
    J Clin Psychiatry 71:1605-11. 2010
    ..Little research has been done on pharmacologic interventions that could address this problem. Ketamine, an N-methyl-D-asparate antagonist, has been reported to have antidepressant effects within hours...
  65. ncbi A systematic review of intravenous ketamine for postoperative analgesia
    Kevin Laskowski
    Department of Anesthesiology, Perioperative Medicine and Pain Management, College of Medicine, University of Saskatchewan, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK S7N 0W8, Canada
    Can J Anaesth 58:911-23. 2011
    Perioperative intravenous ketamine may be a useful addition in pain management regimens. Previous systematic reviews have included all methods of ketamine administration, and heterogeneity between studies has been substantial...
  66. ncbi Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine
    Vincent Joly
    Department of Anesthesia, Institut National de la Santé et de la Recherche Médicale INSERM E 332, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, France
    Anesthesiology 103:147-55. 2005
    ..study tested the hypotheses that increased pain sensitivity assessed by periincisional allodynia and hyperalgesia can occur after relatively large-dose intraoperative remifentanil and that small-dose ketamine prevents this hyperalgesia.
  67. ncbi Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression
    Marije aan het Rot
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York
    Biol Psychiatry 67:139-45. 2010
    A single subanesthetic (intravenous) IV dose of ketamine might have rapid but transient antidepressant effects in patients with treatment-resistant depression (TRD)...
  68. pmc Successful small intestine colonization of adult mice by Vibrio cholerae requires ketamine anesthesia and accessory toxins
    Verena Olivier
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 4:e7352. 2009
    ..Successful colonization was found to depend upon anesthesia with ketamine-xylazine and neutralization of stomach acid with sodium bicarbonate, but not streptomycin treatment...
  69. pmc Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine
    Xiaoping Gu
    Department of Anesthesiology, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, Jiangsu Province, China
    Mol Pain 5:76. 2009
    ..of postoperative pain to investigate the role of tyrosine phosphorylation of NMDA receptor 2B (NR2B) subunit in spinal cord in the postoperative hyperalgesia induced by remifentanil and the intervention of pretreatment with ketamine.
  70. pmc Glutamatergic modulators: the future of treating mood disorders?
    Carlos Zarate
    Experimental Therapeutics and Pathophysiology Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Harv Rev Psychiatry 18:293-303. 2010
    ..In addition to evidence confirming the role of the glutamatergic modulators riluzole and ketamine as proof-of-concept agents in this system, trials with diverse glutamatergic modulators are under way...
  71. ncbi Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function
    John H Krystal
    Department of Psychiatry and Division of Biostatistics, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conn 06516, USA
    Arch Gen Psychiatry 62:985-94. 2005
    In healthy individuals, ketamine hydrochloride and amphetamine sulfate produce cognitive, behavioral, and subjective effects resembling endogenous psychoses...
  72. ncbi Differential effects of cocaine and ketamine on time estimation: implications for neurobiological models of interval timing
    Ruey Kuang Cheng
    Department of Psychology and Neuroscience, Genome Sciences Research Building II 3rd Floor, Duke University, Durham, NC 27708, USA
    Pharmacol Biochem Behav 85:114-22. 2006
    The present experiment examined the effects of cocaine (0.0 and 15 mg/kg, i.p.) and ketamine (0.0, 10.0 and 15 mg/kg, i.p.) on timing behavior using a 12-s differential reinforcement of low rates (DRL) procedure and a 2- vs...
  73. ncbi Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial
    Patricia Jabre
    Samu 93 Equipe d accueil EA 3409, Hopital Avicenne, AP HP, Universite Paris 13, Bobigny, France
    Lancet 374:293-300. 2009
    ..We compared early and 28-day morbidity after a single dose of etomidate or ketamine used for emergency endotracheal intubation of critically ill patients.
  74. ncbi Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review
    Kathirvel Subramaniam
    Department of Anesthesiology, Critical Care and Pain Management, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Anesth Analg 99:482-95, table of contents. 2004
    Animal studies on ketamine and opioid tolerance have shown promising results. Clinical trials have been contradictory. We performed a systematic review of randomized, double-blind clinical trials of ketamine added to opioid analgesia...
  75. pmc Exploring the impact of ketamine on the experience of illusory body ownership
    Hannah L Morgan
    Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Downing Site, United Kingdom
    Biol Psychiatry 69:35-41. 2011
    ..This illusion is stronger in schizophrenia. Given the evidence that ketamine, a noncompetitive N-methyl-D-aspartate antagonist reproduces symptoms of schizophrenia, we sought to determine ..
  76. ncbi Ketamine modulates theta and gamma oscillations
    Maciej T Lazarewicz
    Neuroengineering Laboratory, Department of Bioengineering, University of Pennsylvania, Philadelphia 19104, USA
    J Cogn Neurosci 22:1452-64. 2010
    b>Ketamine, an N-methyl-D-aspartate (NMDA) receptor glutamatergic antagonist, has been studied as a model of schizophrenia when applied in subanesthetic doses...
  77. pmc Ketamine and the next generation of antidepressants with a rapid onset of action
    Rodrigo Machado-Vieira
    Experimental Therapeutics Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Pharmacol Ther 123:143-50. 2009
    ..In this context, the N-methyl-D-aspartate (NMDA) antagonist ketamine has consistently shown antidepressant effects within a few hours of its administration...
  78. pmc Psychological effects of ketamine in healthy volunteers. Phenomenological study
    E Pomarol-Clotet
    Benito Menni CASM, Barcelona, Spain
    Br J Psychiatry 189:173-9. 2006
    The psychosis-inducing effect of ketamine is important evidence supporting the glutamate hypothesis of schizophrenia. However, the symptoms the drug produces have not been described systematically.
  79. ncbi Perioperative small-dose S(+)-ketamine has no incremental beneficial effects on postoperative pain when standard-practice opioid infusions are used
    Wolfgang Jaksch
    Department of Anesthesiology and Intensive Care Medicine, Ludwig Boltzmann Institute of Experimental Anesthesiology and Research in Intensive Care Medicine, Wilhelminenspital, Vienna, Austria
    Anesth Analg 94:981-6, table of contents. 2002
    Several studies report that when small-dose racemic ketamine, an N-methyl-D-aspartate receptor antagonist, is administered perioperatively, opioid consumption is reduced postoperatively...
  80. ncbi The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats
    Kristin Engelhard
    Klinik fur Anaesthesiologie, Technische Universitat Munchen, Klinikum rechts der Isar, Munich, Germany
    Anesth Analg 96:524-31, table of contents. 2003
    In this study, we investigated whether the neuroprotection previously seen with dexmedetomidine or S(+)-ketamine involves regulation of proapoptotic (Bax and p53) and antiapoptotic (Bcl-2 and Mdm-2) proteins...
  81. ncbi Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture
    Cheng Wang
    Division of Neurotoxicology, National Center for Toxicological Research Food and Drug Administration, Jefferson, Arkansas 72079 0502, USA
    Toxicol Sci 91:192-201. 2006
    b>Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is used as a general pediatric anesthetic. Recent data suggest that anesthetic drugs may cause neurodegeneration during development...
  82. ncbi The role of ketamine in pain management
    E Visser
    Department of Anaesthesia and Pain Medicine, Royal Perth Hospital, and University of Western Australia, School of Medicine and Pharmacology, Perth, WA 6847, Australia
    Biomed Pharmacother 60:341-8. 2006
    b>Ketamine is a dissociative anaesthetic; its mechanism of action is primarily an antagonism of the N-methyl-D-aspartate (NMDA) receptor...
  83. ncbi Ketamine and postoperative pain--a quantitative systematic review of randomised trials
    Nadia Elia
    EBCAP Institute Evidence Based Critical care, Anaesthesia and Pain treatment, Division of Anaesthesiology, Geneva University Hospitals, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Pain 113:61-70. 2005
    b>Ketamine, an N-methyl-D-aspartate receptor antagonist, is known to be analgesic and to induce psychomimetic effects. Benefits and risks of ketamine for the control of postoperative pain are not well understood...
  84. pmc Ketamine increases human motor cortex excitability to transcranial magnetic stimulation
    V Di Lazzaro
    Institute of Neurology, Universita Cattolica, Largo A Gemelli 8, 00168 Rome, Italy
    J Physiol 547:485-96. 2003
    Subanaesthetic doses of the N-methyl-D-aspartate (NMDA) antagonist ketamine have been shown to determine a dual modulating effect on glutamatergic transmission in experimental animals, blocking NMDA receptor activity and enhancing non-..
  85. pmc Impact of ketamine on neuronal network dynamics: translational modeling of schizophrenia-relevant deficits
    Bernat Kocsis
    Laboratory of Neurophysiology, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    CNS Neurosci Ther 19:437-47. 2013
    Subanesthetic doses of the psychomimetic, ketamine, have been used for many years to elicit behavioral effects reminiscent of schizophrenia in both healthy humans and in animal models of the disease...
  86. ncbi Effect of intravenous lidocaine and ketamine on the minimum alveolar concentration of isoflurane in goats
    Tom Doherty
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Vet Anaesth Analg 34:125-31. 2007
    To evaluate the effects of i.v. lidocaine (L) and ketamine (K), alone and in combination (LK), on the minimum alveolar concentration (MAC) of isoflurane (ISO) in goats.
  87. ncbi The anti-inflammatory effects of ketamine: state of the art
    S Loix
    Intensive Care Unit, Jolimont Hospital, La Louvibre, Belgium
    Acta Anaesthesiol Belg 62:47-58. 2011
    ..Among these drugs, ketamine seems to have a significant positive effect on the regulation of inflammation...
  88. ncbi Ketamine effects on the urogenital system--changes in the urinary bladder and sperm motility
    Sijie Tan
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Microsc Res Tech 74:1192-8. 2011
    Different doses of ketamine (10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, 50 mg/kg, and 60 mg/kg) were injected i.p. (I.P.), respectively, to male ICR mice to determine the optimal dosage for chronic administration. At and above 40 mg/kg I.P...
  89. ncbi Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS study
    Laura M Rowland
    Department of Psychiatry, MIND Imaging Center, University of New Mexico, USA
    Am J Psychiatry 162:394-6. 2005
    ..The authors' goal was to test in humans the hypothesis that N-methyl-d-aspartate receptor (NMDAR) antagonism results in increased cortical glutamate activity, as proposed by the NMDAR hypofunction model of schizophrenia...
  90. ncbi Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-up
    Evgeny Krupitsky
    St Petersburg Research Center of Addictions and Psychopharmacology, Novo Deviatkino 19 1, Leningrad Region 188661, Russia
    J Subst Abuse Treat 23:273-83. 2002
    Seventy detoxified heroin-addicted patients were randomly assigned to one of two groups receiving ketamine psychotherapy (KPT) involving two different doses of ketamine...
  91. ncbi Remifentanil in combination with ketamine versus remifentanil in spinal fusion surgery--a double blind study
    B A Hadi
    Faculty of Pharmacy, Philadelphia University, 2Arab Medical Center, Amman, Jordan
    Int J Clin Pharmacol Ther 48:542-8. 2010
    ..This study is aimed at conducting a program for two different anesthetic methods used during a spinal fusion surgery to ensure better intra-operative hemodynamic stability and post-operative pain control...
  92. ncbi Recreational ketamine: from pleasure to pain
    Dan Wood
    Department of Urology, University College London Hospitals, UK
    BJU Int 107:1881-4. 2011
    b>Ketamine has become increasingly recognized as a drug of recreational use. Individuals using significant amounts have developed symptoms including a small painful bladder, ureteric obstruction, papillary necrosis and hepatic dysfunction...
  93. ncbi Dual involvements of cyclooxygenase and nitric oxide synthase expressions in ketamine-induced ulcerative cystitis in rat bladder
    Shu Mien Chuang
    Yuh Ing Junior College of Health Care and Management, Kaohsiung, Taiwan
    Neurourol Urodyn 32:1137-43. 2013
    ..The aims of the present study were to investigate voiding patterns, tissue constituents and the expressions of cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS) involved in ketamine-induced ulcerative cystitis in rat urinary bladder.
  94. ncbi Reversal of ketamine-induced working memory impairments by the GABAAalpha2/3 agonist TPA023
    Stacy A Castner
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Biol Psychiatry 67:998-1001. 2010
    b>Ketamine has been used to model cognitive and behavioral symptoms of schizophrenia...
  95. pmc Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine
    Giacomo Salvadore
    Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 35:1415-22. 2010
    ..treatment responders from non-responders to various pharmacological antidepressant interventions, including ketamine, an N-methyl-D-aspartate receptor antagonist...
  96. ncbi The influence of fentanyl vs. s-ketamine on intubating conditions during induction of anaesthesia with etomidate and rocuronium
    T Ledowski
    Department of Anaesthesiology and Intensive Care Medicine, Hospital of the Christian-Albrechts-University, Schwanenweg 21, D24105 Kiel, Germany
    Eur J Anaesthesiol 18:519-23. 2001
    BACKGROUND AND OBJECTIVE: In the present study, we investigated the combination of etomidate and s-ketamine with regard to its suitability for modified rapid-sequence induction using rocuronium for muscle relaxation...
  97. ncbi The psychotomimetic states inventory (PSI): measuring psychotic-type experiences from ketamine and cannabis
    Oliver J Mason
    Sub Department of Clinical Health Psychology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Schizophr Res 103:138-42. 2008
    This study reports a new measure of psychotomimetic states in the context of cannabis and ketamine use...
  98. ncbi A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: microPET Imaging using 18F-annexin V
    Xuan Zhang
    Division of Neurotoxicology, National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Toxicol Sci 111:355-61. 2009
    It has been reported that suppression of N-methyl-D-aspartate (NMDA) receptor function by ketamine may trigger apoptosis of neurons when given repeatedly during the brain growth spurt period...
  99. ncbi The effects of ketamine-xylazine anesthesia on cerebral blood flow and oxygenation observed using nuclear magnetic resonance perfusion imaging and electron paramagnetic resonance oximetry
    H Lei
    NMR Research Center, Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH 03755, USA
    Brain Res 913:174-9. 2001
    b>Ketamine-xylazine is a commonly used anesthetic for laboratory rats...
  100. ncbi Glutamatergic approaches in major depressive disorder: focus on ketamine, memantine and riluzole
    R T Owen
    Drugs Today (Barc) 48:469-78. 2012
    ..The NMDA receptor antagonist ketamine has been investigated in various mood disorders, especially major depressive disorder (MDD)...
  101. ncbi Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy
    T Yamamoto
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Pain 72:5-12. 1997
    ..characteristics of this intractable pain syndrome were investigated by the morphine, thiamylal and ketamine tests...

Research Grants64

  1. Remodeling Neuronal Chromatin in Mouse Models for Depression
    Schahram Akbarian; Fiscal Year: 2013
    ..This finding is interesting because the non-specific NMDA receptor antagonist, ketamine, and the NR2B selective antagonist, CP101,606 elicit rapid antidepressant action in depressed subjects, including ..
  2. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..The second involves reflex cardiovascular depression during mild gastric distension in ketamine-xylazine anesthetized rats, which appears to inhibit the prevagal neurons in the NA and presympathetic neurons in ..
  3. The Antidepressant Action of Ketamine:Brain Chemistry
    MATE ISTVAN MILAK; Fiscal Year: 2013
    ..Studies report that a single intravenous sub-anesthetic dose of ketamine (an NMDA receptor antagonist) can bring about full remission in hours, even in treatment-resistant MDD...
  4. Drug Discovery for Cognitive Impairment Associated with Drugs of Abuse
    Alvin V Terry; Fiscal Year: 2013
    ..we have characterized reversible pharmacological models for impairments in working memory in monkeys utilizing ketamine (hallucinogen);nomifensine (cocaine/amphetamine-like activity);and amitriptyline (biogenic amine uptake inhibitor/..
  5. Anesthetic Action: Molecular Substrates &Neural Mechanisms
    Douglas A Bayliss; Fiscal Year: 2013
    ..Proposed experiments focus primarily on HCN1-mediated actions of ketamine, a dissociative anesthetic for which a robust decrease in hypnotic sensitivity was obtained in conventional HCN1 ..
  6. Effects of lithium on cellular signaling
    Richard S Jope; Fiscal Year: 2011
    ..We will test if the rapid antidepressant effect of ketamine involves inhibition of GSK3, test if neurotrophins or inflammatory molecules are altered by GSK3 and associated ..
  7. Rational polytherapy in the treatment of cholinergic seizures
    Claude G Wasterlain; Fiscal Year: 2013
    ..2/ a NMDA receptor antagonist which could be non-specific (dizocilpine or ketamine) or NR2B subunit-preferring (R025-6981 or felbamate), and 3/ an anticonvulsant acting at a non-GABA site such as ..
  8. The rodent continuous performance task: Filling the vigilance translational gap
    JARED WILLIAM YOUNG; Fiscal Year: 2010
    ..whether psychostimulants such as nicotine, amphetamine, and methylphenidate will improve performance and whether ketamine will impair vigilance performance, consistent with human CPT studies...
  9. Electrophysiological mapping of corticocollicular projections involved with tonot
    HUBERT HYUNGIL LIM; Fiscal Year: 2013
    ..Furthermore, BF shifts within ICC have also shown to contribute to BF shifts within A1. Using ketamine-anesthetized guinea pigs, the proposed studies will investigate how electrical stimulation of different frequency ..
  10. Effects of lithium on cellular signaling
    Richard S Jope; Fiscal Year: 2013
    ..We will test if the rapid antidepressant effect of ketamine involves inhibition of GSK3, test if neurotrophins or inflammatory molecules are altered by GSK3 and associated ..
  11. The role of spontaneous neurotransmission in synaptic plasticity and behavior
    Devon C Crawford; Fiscal Year: 2013
    ..and behavior, but prior work has implicated its inhibition in the fast-acting antidepressant effects of low-dose ketamine administration in treatment-resistant depression...
  12. RAPIDLY-ACTING TREATMENTS FOR TREATMENT-RESISTANT DEPRESSION (RAPID)
    Maurizio Fava; Fiscal Year: 2011
    ..Over the last decade, a series of studies has demonstrated the ability of novel approaches [unreadable] including ketamine and sleep deprivation therapy [unreadable] to provide significant amelioration of symptoms within a few hours...
  13. The 5-HT theory of depression tested in a naturalistic model of 5-HT deficiency
    Marc G Caron; Fiscal Year: 2013
    ..Aim 2 will test whether antidepressant- like responses to SSRI and ketamine are affected by 5-HT deficiency...
  14. Dysregulation of glial glutamate transmission as a model of depressive illness
    ANITA JEAN BECHTHOLT GOMPF; Fiscal Year: 2011
    ..suggest a causal link between glutamatergic function and the treatment of depression by demonstrating that ketamine, an antagonist at NMDA (glutamate) receptors, has antidepressant effects in humans and laboratory animals (Maeng ..
  15. Novel Interventions for Adults with Obsessive-Compulsive Disorder
    Carolyn I Rodriguez; Fiscal Year: 2013
    ..Project #2: is a randomized trial of ketamine, a glutamate receptor antagonist, in drug free OCD patients who have failed prior SRI trials...
  16. Sex Differences in Ketamine Antidepressant Effects
    Yi Zhou; Fiscal Year: 2013
    ..However, recent clinical studies have shown that a single low-dose injection of ketamine, an N-methyl d-aspartate receptor (NMDAR) antagonist, has rapid antidepressant effects that are observed within ..
  17. PATHOGENESIS OF RETT SYNDROME
    SAKKUBAI R NAIDU; Fiscal Year: 2010
    ..Also, the effect of ketamine-induced blocking of glutamate receptors on dopamine release will be investigated...
  18. Delineating NMDA Receptor Hypofunctions Role in Schizophrenia Pathophysiology
    KAZUTOSHI NAKAZAWA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): NMDAR antagonists, including phencyclidine, ketamine and MK-801, induce a psychotic reaction in human subjects that resembles many of schizophrenia symptoms leading the NMDA receptor (NMDAR) ..
  19. Cellular Mechanisms of General Anesthetic Mediated Neurotoxicity
    Deborah J Culley; Fiscal Year: 2010
    ..To test this hypothesis, we will use a few selected general anesthetic agents (ketamine, propofol, isoflurane) and a cell culture model that permits the maturity and differentiation state of the cells ..
  20. Antidepressants and Intracellular Signaling Linked to BDNF
    Lisa M Monteggia; Fiscal Year: 2013
    ..A rather surprising finding in the field of depression has been the demonstration that ketamine, an ionotropic glutamatergic n-methyl-daspartate (NMDA) receptor antagonist, has rapid and long-lasting ..
  21. Improving Psychiatric Interventions at the End of Life
    Scott A Irwin; Fiscal Year: 2012
    ..Several other studies have been completed investigating ketamine for the rapid treatment of depression in hospice patients, as well as studies of cognitive impairments, hospice ..
  22. Drugs of Abuse and Memory Span
    JOSEPH MARK GALIZIO; Fiscal Year: 2012
    ..using the span procedure including benzodiazepines (chlordiazepoxide, midazolam), NMDA antagonists (dizocilpine, ketamine), opiates (morphine), psychostimulants (methylphenidate, methamphetamine, MDMA), and an anticholinergic ..
  23. Long-term neurobehavioral effects of ketamine exposure in adolescent mice
    Steven J Siegel; Fiscal Year: 2012
    ..follows the Principal Investigator's Phase I application entitled, Evoked potentials and vulnerability to ketamine in mice (5-R21-DA-017082-02)...
  24. An NMDA Glycine Site Antagonist for the Treatment of Major Depressive Disorder
    Robert Schwarcz; Fiscal Year: 2013
    ..A recent exciting development is the finding that ketamine, which is widely used as an anesthetic in surgical settings, has efficacy as a rapidly acting antidepressant in ..
  25. Circumventing physiological consequences of drug abuse
    Anthony A Grace; Fiscal Year: 2013
    ..neuron activity can be reversed by inactivating the amygdala or by administering the NMDA channel blocker ketamine;a drug that is known to be a rapidly acting antidepressant...
  26. THE BEHAVIORAL PHARMACOLOGY OF PHENCYCLIDINE
    Robert L Balster; Fiscal Year: 2010
    The abuse of phencyclidine (PCP) and ketamine remain important public health problems...
  27. Anesthesia Toxicity in Neonatal Primate Brain
    John W Olney; Fiscal Year: 2013
    ..and oligodendrocytes) induced by clinically relevant exposure to each of three anesthetic drugs (isoflurane, ketamine, propofol)...
  28. Imaging the antipsychotic actions of metabotropic glutamate receptor-2 activators
    John C Gore; Fiscal Year: 2013
    ..suggest that mGlu2/3 activation is effective in improving both positive and negative symptoms and a study in ketamine-induced working memory deficits in human subjects suggests that cognition can be improved, too...
  29. Sensitive and Treatable Periods of Brain-Redox Imbalance in Schizophrenia
    Susan B Powell; Fiscal Year: 2013
    ..e. perinatal exposure to the NMDA receptor antagonist ketamine (pNM model), and social isolation rearing (SI model)...
  30. Mechanisms underlying fast-onset antidepressant effects of 5-HT2C antagonists - R
    Stephanie C Dulawa; Fiscal Year: 2013
    ..None of these, including the noncompetitive NMDA antagonist ketamine, are approved for clinical use due to adverse side effects...
  31. Brief Potent Glutamatergic Modulation: Applications for Cocaine Dependence
    Elias Dakwar; Fiscal Year: 2013
    ..Specifically, this proposal will focus on treating cocaine dependence with sub-anesthetic infusions of ketamine, a high-affinity non-competitive N- methyl-D-aspartate receptor (NMDAR) antagonist, which has recently emerged as ..
  32. Functional MRI Studies of Emotion in Depression and Rapid Antidepressant Response
    JAMES WARREN MURROUGH; Fiscal Year: 2013
    ..e., experience TRD). Recent findings of rapid and robust antidepressant effects of the anesthetic agent ketamine, a N-methyl-D-aspartate (NMDA) glutamate receptor antagonist, present a unique opportunity to test hypotheses ..
  33. Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling
    Chadi Abdallah; Fiscal Year: 2013
    ..a pharmaco-imaging paradigm to study the mechanisms underlying the antidepressant and psychotomimetic effects of ketamine. Ketamine is an anesthetic agent, recently found to exert a rapid and potent antidepressant effect in severely ..
  34. Characterizing Cognitive Impairment in Schizophrenia via Computational Modeling a
    Alan Anticevic; Fiscal Year: 2013
    ..of schizophrenia that perturbs the precise mechanism in healthy volunteers, namely transient NMDA antagonism via ketamine;iii) to relate these pharmacological results to deficits observed in patients using behavior and functional ..
  35. Role of p70S6 kinase in the synaptic and behavioral deficits induced by stress
    Jason Dwyer; Fiscal Year: 2013
    ..Recent evidence has identified that the drug ketamine produces rapid and robust effects in depressed patients (Berman et al., 2000;Zarate et al...
  36. Role of mTOR and Synaptogenesis in the Actions of Rapid-Acting Antidepressants
    Ronald S Duman; Fiscal Year: 2013
    ..Recent studies demonstrate that a single low dose of ketamine, a glutamate-NMDA receptor antagonist, produces rapid antidepressant actions (2 hr) that last for up to 7 days in ..
  37. Ketamine vs Midazolam: Testing Rapid Relief of Suicide Risk in Depression
    Michael F Grunebaum; Fiscal Year: 2013
    ..suicidal ideation, in as little as one hour, in depressed patients after intravenous infusion of sub-anesthetic ketamine, a glutamate antagonist and commonly used anesthetic...
  38. GABAergic Control of Depression Related Brain States
    Bernhard Luscher; Fiscal Year: 2013
    ..Treatment of mutant cultures with ketamine results in reversal of these deficits...
  39. Identifying Virtual Reality Analgesia Mechanisms by Pharmacologic Manipulation
    Sam R Sharar; Fiscal Year: 2013
    ..the comparative and additive effects of immersive VR and N-methyl-D-aspartate (NMDA) antagonism with low- dose ketamine (at a sub-anesthetic dose devoid of hallucinatory effects, but associated with analgesia, expansive mood, and ..
  40. Translational Neuroscience Optimization of GlyT1 Inhibitor
    John H Krystal; Fiscal Year: 2013
    ..facilitation of NMDAR function;we will determine whether PF-03463275 produces dose-related attenuation of the ketamine-induced disruption in prefrontal cortical BOLD activation related to working memory...
  41. Optimization of IV Ketamine for Treatment Resistant Major Depression
    Sanjay J Mathew; Fiscal Year: 2012
    ..b>Ketamine, a high-affinity NMDA glutamate receptor antagonist, is an anesthetic and analgesic medication commonly used in ..
  42. Neurotoxicity of NMDA Receptor Antagonists
    Frank Sharp; Fiscal Year: 2005
    ..applicant?s abstract): The non-competitive NMDA receptor antagonists, including phencyclidine (PCP, angel dust), ketamine (Special K), and dizocilpine (MK-801), have been used as anesthetics, protect against experimental stroke, are ..
  43. Patterns of Drug Use and Abuse in the Brazilian Rave Culture
    James Inciardi; Fiscal Year: 2009
    ..S. the most popular of the club drugs have been MDMA (ecstasy), GHB, ketamine, LSD, methamphetamine, and a few prescription drugs, such as dextroamphetamine and methylphenidate...
  44. The Effect of Glutamatergic Modulation on Cocaine Self-Administration
    Elias Dakwar; Fiscal Year: 2013
    ..Our preliminary investigations with ketamine, a glutamatergic modulator with potent prefrontal effects, suggest that it represents a promising Candidate...
  45. Tumor NMR Images are Affected by Anesthetic
    Natarajan Raghunand; Fiscal Year: 2006
    ..effects, and resulting effects upon DCE-MRI images, using three commonly used anesthetic protocols: ketamine/xylazine/acepromazine, pentobarbital, and isoflurane, and one customized injectable anesthetic protocol: ..
  46. Mentored Patient-Oriented Research Career Development Aw
    Kelly Young; Fiscal Year: 2004
    ..as a measure of the long-term effects of painful experiences; and 4) to test a pharmacological (intramuscular ketamine and midazolam) and a behavioral (blowing on a party blower) intervention for reducing the pain and stress ..
  47. Regulation of Protein Translation and Depression by Cortical NMDA Receptors.
    Benjamin Hall; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A single, low dose of the n-methyl d-aspartate receptor (NMDAR) antagonist ketamine produces rapid anti-depressant actions in treatment-resistant depressed patients...
  48. Evoked potentials and vulnerability to ketamine in mice.
    Steven Siegel; Fiscal Year: 2004
    ..Background: Abuse of NMDA receptor antagonists, such as ketamine and phencyclidine (PCP), has been recognized for many years...
  49. MOLECULAR STUDIES OF ANESTHETIC-MUSCARINIC INTERACTIONS
    Marcel Durieux; Fiscal Year: 1999
    ..anesthetics have been shown to inhibit muscarinic signaling, and some non-volatile anesthetic agents, such as ketamine and althesin, similarly appear to affect the system...
  50. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2002
    ..The noncompetitive NMDA receptor antagonist ketamine, induces symptoms in healthy individuals resembling several aspects of schizophrenia...
  51. Impulsivity and Demand for Drug in Rhesus Monkeys
    GAIL D WINGER; Fiscal Year: 2012
    ..g., ketamine or short-acting barbiturates)...
  52. QTLS UNDERLYING MOLECULAR ACTION OF GENERAL ANESTHETICS
    Thomas Johnson; Fiscal Year: 2000
    ..QTLs are to be identified for other general anesthetics (isoflurane, enflurane, etomidate, halothane, and ketamine) using both LS x SS recombinant inbred strains and F2 mice...
  53. MGT SVCS/CONTRACT &PROCUREMENT SUP
    X X; Fiscal Year: 2013
    ..The study shall be a double-blind, placebo-controlled study of the acute efficacy of ketamine for the treatment of adults with treatment-resistant depression...
  54. Trends in Club Drug Use
    Christopher Krebs; Fiscal Year: 2002
    ..lysergic acid diethylamide (LSD), methylene-dioxy-methamphetamine (MDMA or Ecstasy), gamma-hydroxybutyrate (GHB), Ketamine, Rohypnol, methamphetamine, and psilocybin, are gaining in popularity, users are getting younger, and serious ..
  55. HIV RISK AND KETAMINE INJECTION AMONG HIGH RISK YOUTH
    STEPHEN LANKENAU; Fiscal Year: 2001
    ..adapted from the applicant's abstract): "Club drugs," a relatively new category of illicit drugs that includes ketamine, MDMA (ecstasy), GHB, and methamphetamine, have become increasingly common across a variety of subpopulations...
  56. Club drug use/sexual risk-taking among Latino/other MSM
    JOHN ECHEVERRY; Fiscal Year: 2007
    ..properties, such as methamphetamine (crystal meth), 3-4 methylenedioxymethamphetamine (MDMA, or Ecstasy), ketamine (Special K), gamma hydroxybutyrate (GHB), and volatile nitrites (poppers)...
  57. DEVELOPMENT OF TRANSNASAL KETAMINE FOR BREAKTHROUGH PAIN
    FRED MERMELESTEIN; Fiscal Year: 2000
    ..abstract): The objectives of this proposal are to determine the safety and analgesic efficacy of transnasal ketamine in a Phase I clinical study as the first step towards FDA approval and commercialization...
  58. Youth, Technology, and the Proliferation of Drug Use
    DANIEL MURGUIA; Fiscal Year: 2002
    ..MDMA (ecstasy), Lysergic Acid Diethylamide (LSD), Rohypnol, Methamphetamine, Ketamine, and Gammahydroxybutyrate (GBH) are substances generally labeled "club drugs...
  59. Abused NMDA Antagonists: Effects on Cortical Development
    Mary Wilson; Fiscal Year: 2004
    This R21 application evaluates the hypothesis that the abused NMDA antagonists ketamine and dextromethorphan, by altering the function and expression of glutamate receptors, may have detrimental effects on the development of neocortex...
  60. NEUROPHARMACOLOGIC CHALLENGES IN DEMENTIA
    Norman Foster; Fiscal Year: 1992
    ..acetylcholine and glutamate upon cognition in dementia, we will investigate the cognitive effects of intravenous ketamine, a glutaminergic antagonist, and scopolamine, a cholinergic antagonist, in these disorders...
  61. KAINATE RECEPTOR ANTAGONISTS TO TREAT NEUROPATHIC PAIN
    MARIA MACCECCHINI; Fiscal Year: 1999
    ..Such a therapeutic agent would fulfill a tremendous unmet need since opiates and ketamine (by continuous i.v. infusion) are the only available compounds that can alleviate neuropathic pain...
  62. HIV RISK AND CLUB DRUGS AMONG MSM--A TWO CITY COMPARISON
    Patricia Case; Fiscal Year: 2002
    ..and inhaled nitrites, as well as a number of relatively new and as yet unexamined substances such as ketamine and MDMA...
  63. PCP AND EXTRACELLULAR DOPAMINE IN BRAIN
    DIANA JAUCH; Fiscal Year: 1993
    ..psychosis circuit" will be examined by 2-deoxyglucose (2DG) autoradiography in rats given the PCP agonist ketamine or CPP, a competitive NMDA antagonist, and by use of positron emission tomography (PET) scanning in ..
  64. Norketamine for Treatment of Pain
    JOSEPH HOLTMAN; Fiscal Year: 2003
    ..b>Ketamine, a clinically available nonselective NMDA receptor antagonist, has been used parenterally for pain...