pristinamycin

Summary

Summary: An antibiotic mixture originally isolated from Streptomyces pristinaspiralis. It is a mixture of compounds from STREPTOGRAMIN GROUP A: pristinamycin IIA and IIB and from STREPTOGRAMIN GROUP B: pristinamycin IA, pristinamycin IB, pristinamycin IC.

Top Publications

  1. ncbi Bidirectional expression units enable streptogramin-adjustable gene expression in mammalian cells
    Cornelia Fux
    Institute of Biotechnology, Swiss Federal Institute of Technology, ETH Zurich, CH 8093 Zurich, Switzerland
    Biotechnol Bioeng 83:618-25. 2003
  2. ncbi Successful oral pristinamycin therapy for osteoarticular infections due to methicillin-resistant Staphylococcus aureus (MRSA) and other Staphylococcus spp
    John Ng
    Department of Microbiology and Infectious Diseases, South Western Area Pathology Service, Liverpool, New South Wales, Australia
    J Antimicrob Chemother 55:1008-12. 2005
  3. ncbi Probing the molecular mechanisms for pristinamycin yield enhancement in Streptomyces pristinaespiralis
    Qingchao Jin
    Department of Biological and Pharmaceutical Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo, China
    Curr Microbiol 65:792-8. 2012
  4. ncbi Improved production of pristinamycin coupled with an adsorbent resin in fermentation by Streptomyces pristinaespiralis
    Bo Jia
    Department of Chemical Engineering and Bioengineering, Zhejiang University, Hangzhou, 310027, PR China
    Biotechnol Lett 28:1811-5. 2006
  5. ncbi Evolution of Streptomyces pristinaespiralis for resistance and production of pristinamycin by genome shuffling
    Bo Xu
    College of Materials Science and Chemical Engineering, Institute of Bioengineering, Zhejiang University, 310027, Hangzhou, People s Republic of China
    Appl Microbiol Biotechnol 80:261-7. 2008
  6. ncbi Conjugal transferring of resistance gene ptr for improvement of pristinamycin-producing Streptomyces pristinaespiralis
    Zhihua Jin
    Department of Chemical and Biochemical Engineering, Zhejiang University, 310027, Hangzhou, People s Republic of China
    Appl Biochem Biotechnol 160:1853-64. 2010
  7. pmc Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis
    Yvonne Mast
    Mikrobiologie Biotechnologie, Interfakultäres Institut für Mikrobiologie und Infektionsmedizin, Fakultat fur Biologie, Eberhard Karls Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Microb Biotechnol 4:192-206. 2011
  8. ncbi Pleiotropic functions of a Streptomyces pristinaespiralis autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase
    M Folcher
    Department of Molecular Microbiology, Biocenter, 70 Klingelbergstrasse, University of Basel, 4056 Basel, Switzerland
    J Biol Chem 276:44297-306. 2001
  9. ncbi Pristinamycin-inducible gene regulation in mycobacteria
    Francesca Forti
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26 20133 Milano, Italy
    J Biotechnol 140:270-7. 2009
  10. ncbi Fatal pristinamycin-induced toxic epidermal necrolysis (Lyell's syndrome): difficulties in attributing causal association in the polymedicated intensive care unit patient
    G Chanques
    Acta Anaesthesiol Scand 49:721-2. 2005

Research Grants

  1. INTERACTION OF ANTIBIOTICS WITH RIBOSOMAL RNA
    Alexander Mankin; Fiscal Year: 1999
  2. ANTIBIOTIC INHIBITION OF BACTERIAL RIBOSOME FORMATION
    WILLIAM CHAMPNEY; Fiscal Year: 2002

Detail Information

Publications143 found, 100 shown here

  1. ncbi Bidirectional expression units enable streptogramin-adjustable gene expression in mammalian cells
    Cornelia Fux
    Institute of Biotechnology, Swiss Federal Institute of Technology, ETH Zurich, CH 8093 Zurich, Switzerland
    Biotechnol Bioeng 83:618-25. 2003
    ..of two desired transgenes in response to clinically licensed antibiotics of the streptogramin class (pristinamycin, Pyostacin, Synercid)...
  2. ncbi Successful oral pristinamycin therapy for osteoarticular infections due to methicillin-resistant Staphylococcus aureus (MRSA) and other Staphylococcus spp
    John Ng
    Department of Microbiology and Infectious Diseases, South Western Area Pathology Service, Liverpool, New South Wales, Australia
    J Antimicrob Chemother 55:1008-12. 2005
    ..b>Pristinamycin is a possible alternative and we report our experience with this agent.
  3. ncbi Probing the molecular mechanisms for pristinamycin yield enhancement in Streptomyces pristinaespiralis
    Qingchao Jin
    Department of Biological and Pharmaceutical Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo, China
    Curr Microbiol 65:792-8. 2012
    The mechanisms for the enhancement of pristinamycin production in the high-yielding recombinants of Streptomyces pristinaespiralis obtained by genome shuffling were investigated by quantitative real-time PCR (Q-PCR) and amplified ..
  4. ncbi Improved production of pristinamycin coupled with an adsorbent resin in fermentation by Streptomyces pristinaespiralis
    Bo Jia
    Department of Chemical Engineering and Bioengineering, Zhejiang University, Hangzhou, 310027, PR China
    Biotechnol Lett 28:1811-5. 2006
    ..by Streptomyces pristinaespiralis with the addition of adsorbent resins was used to increase the production of pristinamycin. In consideration of the adsorption capacity and the desorption ability, a polymeric resin, JD-1, was finally ..
  5. ncbi Evolution of Streptomyces pristinaespiralis for resistance and production of pristinamycin by genome shuffling
    Bo Xu
    College of Materials Science and Chemical Engineering, Institute of Bioengineering, Zhejiang University, 310027, Hangzhou, People s Republic of China
    Appl Microbiol Biotechnol 80:261-7. 2008
    Improvement of pristinamycin production by Streptomyces pristinaespiralis was performed by using recursive protoplast fusion and selection for improved resistance to the product antibiotic in a genome shuffling format...
  6. ncbi Conjugal transferring of resistance gene ptr for improvement of pristinamycin-producing Streptomyces pristinaespiralis
    Zhihua Jin
    Department of Chemical and Biochemical Engineering, Zhejiang University, 310027, Hangzhou, People s Republic of China
    Appl Biochem Biotechnol 160:1853-64. 2010
    Improving pristinamycin production from Streptomyces pristinaespiralis was performed by introducing the resistance gene ptr followed by selection for enhanced tolerance to pristinamycin and fermentation test. To transfer ptr into S...
  7. pmc Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis
    Yvonne Mast
    Mikrobiologie Biotechnologie, Interfakultäres Institut für Mikrobiologie und Infektionsmedizin, Fakultat fur Biologie, Eberhard Karls Universitat Tubingen, Auf der Morgenstelle 28, D 72076 Tubingen, Germany
    Microb Biotechnol 4:192-206. 2011
    b>Pristinamycin, produced by Streptomyces pristinaespiralis Pr11, is a streptogramin antibiotic consisting of two chemically unrelated compounds, pristinamycin I and pristinamycin II...
  8. ncbi Pleiotropic functions of a Streptomyces pristinaespiralis autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase
    M Folcher
    Department of Molecular Microbiology, Biocenter, 70 Klingelbergstrasse, University of Basel, 4056 Basel, Switzerland
    J Biol Chem 276:44297-306. 2001
    ..pristinaespiralis contains a gene cluster encoding enzymes and regulatory proteins for the biosynthesis of pristinamycin, a clinically important streptogramin antibiotic complex...
  9. ncbi Pristinamycin-inducible gene regulation in mycobacteria
    Francesca Forti
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26 20133 Milano, Italy
    J Biotechnol 140:270-7. 2009
    ..on the Streptomyces coelicolor Pip repressor, the Streptomyces pristinaespiralis ptr promoter and the inducer pristinamycin I...
  10. ncbi Fatal pristinamycin-induced toxic epidermal necrolysis (Lyell's syndrome): difficulties in attributing causal association in the polymedicated intensive care unit patient
    G Chanques
    Acta Anaesthesiol Scand 49:721-2. 2005
  11. ncbi [Peroneal nerve palsy induced by anterior tibialis pyomyositis]
    Dominique Caparros-Lefebvre
    Service de Neurologie, Centre Hospitalier Universitaire de Pointe à Pitre Les Abymes, Iles de la Gadeloupe, Antilles Françaises
    Ann Med Interne (Paris) 154:187-9. 2003
    ..Muscle biopsy confirmed pyomyositis. Muscle culture was negative. Paresis improved soon after antibiotic therapy was started...
  12. ncbi Phenotypic and molecular characterization of macrolide and streptogramin resistance in Streptococcus mitis from neutropenic patients
    Wafa Achour
    Laboratoire du Centre National de Greffe de Moelle Osseuse, 1006 Tunis, Tunisia
    J Antimicrob Chemother 54:117-21. 2004
    ..To determine the prevalence of macrolide and streptogramin resistance in Streptococcus mitis isolates from neutropenic patients and to identify mechanisms of macrolide and streptogramin resistance in resistant isolates...
  13. ncbi [Treatment of exacerbations of chronic obstructive pulmonary disease with pristinamycin]
    P Leophonte
    Service de Pneumologie, Hopital Larrey, Cliniques des voies respiratoires, Toulouse, France
    Rev Mal Respir 21:261-71. 2004
    b>Pristinamycin is a bactericidal antibiotic whose spectrum covers the main respiratory pathogens including S. pneumoniae poorly sensitive to penicillin...
  14. ncbi Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR)
    A Sidoroff
    Department of Dermatology and Venereology, Medical University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    Br J Dermatol 157:989-96. 2007
    ..It is usually attributed to drugs...
  15. ncbi Three-year outcome in a patient with Staphylococcus lugdunensis discitis
    Mildreth Camacho
    Rheumatology Department, Hĵpital de la Conception, Marseilles, France
    Joint Bone Spine 69:85-7. 2002
    ..Treatment was with ofloxacin and pristinamycin for 1 year. Although he started to improve only 5 months after treatment initiation, the outcome was favorable...
  16. ncbi [Efficacy and safety of pristinamycin vs amoxicillin in community acquired pneumonia in adults]
    F Tremolieres
    Médecine interne maladies infectieuses, Hôpital François Quesnay, CHG Mantes La Jolie, 2 boulevard Sully, 78201 Mantes La Jolie cedex, France
    Pathol Biol (Paris) 53:503-10. 2005
    Evaluation of efficacy and safety of pristinamycin (PRI), compared with amoxicillin (AMX), both at 3 g daily for 7 to 10 days in adults with community-acquired pneumonia (CAP).
  17. ncbi Emergence of a Streptococcus pneumoniae isolate resistant to streptogramins by mutation in ribosomal protein L22 during pristinamycin therapy of pneumococcal pneumonia
    Vincent Cattoir
    Laboratoire de bactériologie virologie hygiène, CHU Henri Mondor, Assistance Publique Hopitaux de Paris, Universite Paris XII, Creteil, France
    J Antimicrob Chemother 59:1010-2. 2007
    ..the mechanism of resistance to macrolides and streptogramins of a Streptococcus pneumoniae strain isolated from blood cultures in an 80-year-old patient suffering from severe pneumonia unsuccessfully treated with pristinamycin.
  18. ncbi Analysis of pristinamycin-resistant Staphylococcus epidermidis isolates in the Tunisian Bone Marrow Transplant Center
    W Achour
    Laboratoire du Centre National de Greffe de Moelle Osseuse, Tunis, Tunisia
    Lett Appl Microbiol 46:358-63. 2008
    We report the analysis of genetic determinants conferring resistance to pristinamycin in Staphylococcus epidermidis strains and epidemiology typing of these strains by pulsed-field gel electrophoresis.
  19. ncbi Cloxacillin versus pristinamycin for superficial pyodermas: a randomized, open-label, non-inferiority study
    O Chosidow
    Department of Internal Medicine, Hopital Pitie Salpetriere, Assistance Publique Hôpitaux de Paris and Université Paris VI, France
    Dermatology 210:370-4. 2005
    Superficial pyodermas may require systemic antibiotics. In a previous open-label trial, oxacillin and pristinamycin achieved similar cure rates, but its design was not truly that of a non-inferiority study.
  20. ncbi Antibiotic resistance patterns of aerobic coryneforms and furazolidone-resistant Gram-positive cocci from the skin surface of the human axilla and fourth toe cleft
    E A Eady
    The Skin Research Centre, Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Antimicrob Chemother 46:205-13. 2000
    ..phenotype with inducible or constitutive cross-resistance to clindamycin and the type B streptogramin, pristinamycin IA...
  21. ncbi Quinupristin/dalfopristin: a review of its use in the management of serious gram-positive infections
    H M Lamb
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 58:1061-97. 1999
    ..is the first parenteral streptogramin antibacterial agent, and is a 30:70 (w/w) ratio of 2 semisynthetic pristinamycin derivatives...
  22. ncbi Lack of effect of streptogramins on hepatic drug metabolism enzymes in the rat
    M R Martinet
    , , Antony, France
    Drug Metab Dispos 20:490-5. 1992
    ..These results suggest that streptogramins have not, in contrast to many commonly used macrolide antibiotics, had potent or specific effects on hepatic drug metabolizing enzymes in rats...
  23. pmc Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among staphylococci
    G Lina
    Faculte de Medecine, Laboratoire de Bacteriologie, Centre national de référence des toxémies à staphylocoques, EA 1655, 69372 Lyon Cedex 08, France
    Antimicrob Agents Chemother 43:1062-6. 1999
    ..aureus and seven strains of coagulase-negative staphylococci. Resistance to pristinamycin and quinupristin-dalfopristin was phenotypically detected in 10 strains of S...
  24. ncbi [Multicenter study of the in vitro sensitivity of genital mycoplasmas to antibiotics]
    C Bebear
    Laboratoire de Bacteriologie, Hopital Pellegrin, Bordeaux, France
    Pathol Biol (Paris) 41:289-93. 1993
    ..5), lymecycline (6.7), erythromycin (72, most I), josamycin (0.9), clindamycin (88), pristinamycin (0.3), ofloxacin (34, most I). For Mh, the percentage of strains I or R was respectively: doxycycline (2...
  25. pmc Molecular analysis of resistance to streptogramin A compounds conferred by the Vga proteins of staphylococci
    Olivier Chesneau
    Unité des Staphylocoques, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 49:973-80. 2005
    ..lincosamides and streptogramin A compounds, while only Vga(B) is able to increase the level of resistance to pristinamycin, a mixture of streptogramin A and streptogramin B compounds...
  26. ncbi [Antibiotics resistance of meticilline-resistant Staphylococcus aureus: detection of the first glycopeptides low sensibility strains in Tunisia]
    M Mastouri
    Laboratoire de Microbiologie, centre hospitalo universitaire F Bourguiba, Monastir 5000, Tunisie
    Pathol Biol (Paris) 54:33-6. 2006
    ..Susceptibility rates to fosfomycin, chloramphenicol, rifampicin and pristinamycin were 7%, 3%, 2% and 0%, respectively. The prevalence of MRSA was 15...
  27. ncbi Antimicrobial susceptibility of bifidobacteria
    C Moubareck
    Laboratoire de Microbiologie, UFR des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, 75270 Paris, France
    J Antimicrob Chemother 55:38-44. 2005
    ..The aim of our study was to analyse the antibiotic susceptibility of various strains of Bifidobacterium spp. to a wide range of antimicrobial agents...
  28. ncbi Complete conversion of antibiotic precursor to pristinamycin IIA by overexpression of Streptomyces pristinaespiralis biosynthetic genes
    G Sezonov
    Laboratoire de Biologie et Génétique Moléculaire, URA CNRS 2225, Orsay, France
    Nat Biotechnol 15:349-53. 1997
    A Streptomyces pristinaespiralis strain, which produces a streptogramin antibiotic pristinamycin II (PII) as a mixture of two biologically active molecules PIIB and PIIA, was genetically engineered to produce exclusively PIIA...
  29. ncbi [In vitro activity of the pristinamycin against the isolated staphylococci in the french hospitals in 1999-2000]
    R Leclercq
    Service de Microbiologie, Centre Hospitalier Universitaire Côte de Nacre, 14033, Caen, France
    Pathol Biol (Paris) 51:400-4. 2003
    ..More than 92% of strains of CNS susceptible or resistant to oxacillin were sensitive to pristinamycin. Pristinamycin displayed a good activity whether the strains were constitutively or inducibly resistant to MLS(..
  30. ncbi Characterisation of in vitro-selected mutants of Ureaplasma parvum resistant to macrolides and related antibiotics
    S Pereyre
    Laboratoire de Bactériologie EA 3671, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Int J Antimicrob Agents 29:207-11. 2007
    ..and related antibiotics (erythromycin, azithromycin, josamycin, quinupristin, quinupristin/dalfopristin, pristinamycin and telithromycin)...
  31. ncbi Effect of antibiotics, alone and in combination, on Panton-Valentine leukocidin production by a Staphylococcus aureus reference strain
    O Dumitrescu
    INSERM U851 and Université Lyon 1, Centre National de Référence des Staphylocoques, Faculte Laennec, Lyon, France
    Clin Microbiol Infect 14:384-8. 2008
    ..5-fold, while clindamycin, linezolid, fusidic acid and rifampicin were inhibitory, and vancomycin, pristinamycin, tetracycline, ofloxacin and co-trimoxazole had no effect...
  32. ncbi [Streptococcal impetigo at topical tacrolimus application sites in a woman with atopic dermatitis]
    G Reynaert
    Service de Dermatologie et Venereologie, CHU, Groupe Hospitalier Sud, Amiens
    Ann Dermatol Venereol 134:261-3. 2007
    ..We report a case of staphylococcal impetigo in a girl treated with tacrolimus ointment (Protopic) for atopic dermatitis...
  33. ncbi European Surveillance of Antimicrobial Consumption (ESAC): outpatient macrolide, lincosamide and streptogramin (MLS) use in Europe
    Samuel Coenen
    Department of General Practice, University of Antwerp Antwerp, Belgium
    J Antimicrob Chemother 58:418-22. 2006
    ..Data on outpatient macrolide, lincosamide and streptogramin (MLS) use in Europe were collected from 25 countries within the ESAC project, funded by DG SANCO of the European Commission, using the WHO ATC/DDD methodology...
  34. pmc Evaluation of the mandibular third molar pericoronitis flora and its susceptibility to different antibiotics prescribed in france
    Jean Louis Sixou
    Equipe de Biologie Buccale UPRES EA 1256, Universite de Rennes 1, 35000 Rennes, France
    J Clin Microbiol 41:5794-7. 2003
    ..Obligate anaerobes were found in almost all cases (32 of 35). Amoxicillin and pristinamycin were the most effective against the flora, particularly aerobic organisms...
  35. ncbi Antibacterial action of amphipathic derivatives of isoniazid against the Mycobacterium avium complex
    N Rastogi
    , Institut Pasteur, Paris, France
    Zentralbl Bakteriol Mikrobiol Hyg A 268:456-62. 1988
    ..Although pristinamycin was shown to bind to M...
  36. ncbi Eczematous-like drug eruption induced by synergistins
    M Michel
    Service de Dermatologie Centre Hospitalier Universitaire, Caen, France
    Contact Dermatitis 34:86-7. 1996
    The authors report 4 cases of eczematous-like drug eruption after oral ingestion of synergistins, pristinamycin (3 cases) and virginiamycin (1 case). The lesions occurred after contact sensitization with topical virginiamycin...
  37. ncbi [Antimicrobial susceptibility of Clostridium difficile clinical isolates collected from 2001 to 2007 in a French university hospital]
    V Cattoir
    Laboratoire de bactériologie virologie hygiène, CHU Henri Mondor, Assistance Publique Hopitaux de Paris, Faculte de Medecine, Universite Paris XII, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Pathol Biol (Paris) 56:407-11. 2008
    ..The aim of this study was to determine the antimicrobial susceptibilities of Clostridium difficile clinical isolates obtained from symptomatic patients suffering from diarrhoea...
  38. ncbi Prevalence and mechanisms of macrolide resistance among Staphylococcus epidermidis isolates from neutropenic patients in Tunisia
    O Bouchami
    National Bone Marrow Transplant Centre, Tunis, Tunisia
    Clin Microbiol Infect 13:103-6. 2007
    ..The vga, vgb and vat genes were amplified from pristinamycin-resistant isolates. The icaA gene was detected in 76.5% of 34 isolates examined in detail...
  39. ncbi Granulomatous mastitis and corynebacteria: clinical and pathologic correlations
    Carole Mathelin
    Service de Gynecologie Obstetrique, Hopital Civil, Strasbourg, France
    Breast J 11:357. 2005
  40. pmc Pristinamycin I biosynthesis in Streptomyces pristinaespiralis: molecular characterization of the first two structural peptide synthetase genes
    V de Crecy-Lagard
    Division Recherche Pharmaceutique, Centre de Recherche de Vitry Alfortville, Rhone Poulenc Rorer S A, Vitry sur Seine, France
    J Bacteriol 179:705-13. 1997
    ..the other led to PI-deficient strains producing normal levels of the polyunsaturated macrolactone antibiotic pristinamycin II, also produced by S. pristinaespiralis...
  41. ncbi [Corynebacterium group D2. Clinical study, biochemical identification and antibiotic sensitivity]
    N Marty
    Laboratoire de Microbiologie, CHU Rangueil, Toulouse
    Pathol Biol (Paris) 36:460-4. 1988
    ..results of MIC determination of 10 antibiotics, show the high activity (100% sensitivity) of vancomycin and pristinamycin, with MIC modes, respectively, 0.5 and 0.03 mg/l...
  42. ncbi Modulation of cardiomyocyte electrical properties using regulated bone morphogenetic protein-2 expression
    Carlota Diaz Sanchez-Bustamante
    Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland
    Tissue Eng Part A 14:1969-88. 2008
    ..Using lentivirus-derived particles to regulate the bone morphogenetic protein-2 (BMP-2) gene expression in a pristinamycin- or gaseous acetaldehyde-inducible manner, we demonstrated the adjustment of cardiomyocyte ..
  43. ncbi Emergence of Staphylococcus aureus strains resistant to pristinamycin in Sfax (Tunisia)
    S Mezghani Maalej
    Laboratoire de Microbiologie, CHU Habib Bourguiba, Rue El Ferdaous, Sfax, Tunisia
    Pathol Biol (Paris) 60:e71-4. 2012
    We report the emergence of Staphylococcus aureus resistant to pristinamycin in Tunisia, and the characterization of the mechanisms of resistance to macrolides and streptogramins.
  44. ncbi Antibiotic resistance and pathogenicity factors in Staphylococcus aureus isolated from mastitic Sahiwal cattle
    Ravinder Kumar
    Livestock Genome Analysis Laboratory, National Dairy Research Institute, Karnal 132 001, India
    J Biosci 36:175-88. 2011
    ..These findings can be utilized in mastitis treatment programmes and antimicrobials strategies in organized herd...
  45. ncbi Chemoenzymatic approach to enantiopure streptogramin B variants: characterization of stereoselective pristinamycin I cyclase from Streptomyces pristinaespiralis
    Christoph Mahlert
    Fachbereich Chemie Biochemie, Philipps Universitat Marburg, Hans Meerwein Strasse, D 35032 Marburg, Germany
    J Am Chem Soc 127:9571-80. 2005
    ..we cloned, overproduced, and biochemically characterized the recombinant thioesterase domain SnbDE TE of the pristinamycin I nonribosomal peptide synthetase from Streptomyces pristinaespiralis...
  46. ncbi A 12 kb nucleotide sequence containing the alanine dehydrogenase gene at 279 degrees on the Bacillus subtilis chromosome
    B Oudega
    Department of Molecular Microbiology, Faculty of Biology, Vrije Universiteit, HV Amsterdam, The Netherlands
    Microbiology 143:1489-91. 1997
    ..The products of two other genes (yukK and yukL) showed significant similarity to known proteins present in databases, e.g. pyoverdin synthase of Pseudomonas aeruginosa and pristinamycin synthase D of Streptomyces pristinaespiralis.
  47. ncbi Beta-haemolytic streptococci in acute pharyngitis
    J Boukadida
    Microbiology Laboratory, Farhat Hached University Hospital, Sousse, Tunisia
    East Mediterr Health J 9:172-7. 2003
    ..All strains were susceptible to benzylpenicillin, amoxicillin, chloramphenicol, rifampicin and pristinamycin. Susceptibility was variable in erythromycin, tetracycline, fosfomycin, telithromycin and levofloxacin...
  48. ncbi Non-susceptibility trends and serotype coverage by conjugate pneumococcal vaccines in a Tunisian paediatric population: a 10-year study
    F Charfi
    Laboratory of Microbiology, Children s Hospital of Tunis, Tunisia
    Vaccine 30:G18-24. 2012
    ..invasive disease (60.6% vs. 45%). All the strains were susceptible to pristinamycin, vancomycin, teicoplanin and fosfomycin. Serotype 14 was the most frequently isolated serotype (22...
  49. pmc Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthetase gene
    V de Crecy-Lagard
    Division Recherche Pharmaceutique, Centre de Recherche de Vitry Alfortville, Rhone Poulenc Rorer S A, Vitry sur Seine, France
    Antimicrob Agents Chemother 41:1904-9. 1997
    ..the activation and incorporation of the last four precursors (proline, 4-dimethylparaaminophenylalanine [for pristinamycin I(A)] or phenylalanine [for virginiamycin S], pipecolic acid, and phenylglycine) were cloned...
  50. ncbi Effects of bioreactor hydrodynamics on the physiology of Streptomyces
    E Olmos
    CNRS, 54505, Vandoeuvre les Nancy, France
    Bioprocess Biosyst Eng 36:259-72. 2013
    ..In a second part, the assumptions made in these works are discussed and put into emphasize. Lastly, the various Streptomyces physiological responses observed are detailed and compared...
  51. pmc In vitro susceptibilities of aerobic and facultative non-spore-forming gram-positive bacilli to HMR 3647 (RU 66647) and 14 other antimicrobials
    F Soriano
    Department of Medical Microbiology, Fundacion Jimenez Diaz, Madrid, Spain
    Antimicrob Agents Chemother 42:1028-33. 1998
    ..compounds (erythromycin, roxithromycin, azithromycin, clarithromycin, josamycin, lincomycin, pristinamycin, and quinupristin-dalfopristin) as well as those of benzylpenicillin, doxycycline, vancomycin, teicoplanin, ..
  52. ncbi [Pristinamycin/Vitamin k antagonists drug interaction: a French pharmacovigilance database study]
    Anne Laure Guiboux
    Centre Régional de Pharmacovigilance de Bourgogne, Centre Hospitalier Universitaire de Dijon, Dijon, France
    Therapie 69:391-4. 2014
    To analyse pristinamycin/vitamin K antagonists (VKA) drug interaction by using data recorded in the French pharmacovigilance database (FPVB).
  53. ncbi [Managing children skin and soft tissue infections]
    F Moulin
    Urgences Pédiatriques, Hopital Saint Vincent de Paul, 82 av Denfert Rochereau, 75014 Paris, France
    Arch Pediatr 15:S62-7. 2008
    ..For toxinic syndromes and necrozing fascitis clindamycin should be added to a beta-lactam because of its action on protein synthesis in particular reducing the toxins production...
  54. ncbi Incidence and antimicrobial susceptibilities of genital mycoplasmas in outpatient women with clinical vaginitis in Athens, Greece
    Nektaria Kechagia
    Alimos Medifirst, Medical Group Practise, Department of Biopathology, Athens, Greece
    J Antimicrob Chemother 62:122-5. 2008
    ..The incidence and antimicrobial susceptibilities of Ureaplasma urealyticum and Mycoplasma hominis, isolated from vaginal and endocervical swabs collected from 369 outpatient women, were determined...
  55. ncbi [French nationwide survey about management of acute osteomyelitis in children]
    K Milcent
    Service de Pediatrie Generale, Rhumatologie Pédiatrique, Centre de Références des Maladies Auto Inflammatoires, CHU de Kremlin Bicêtre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, France
    Arch Pediatr 16:7-13. 2009
    ..However, treatment management remains unclear. The aim of this study was to investigate the current management of acute osteomyelitis in children in France...
  56. ncbi [Co-sensitization to drugs belonging to different chemical classes during the same episode of cutaneous adverse drug reaction: two cases]
    P Dellestable
    Service de Dermatologie, Hopital Fournier, Nancy
    Ann Dermatol Venereol 134:655-8. 2007
    ....
  57. ncbi [Epidemiology of Haemophilus influenzae strains collected in 2004 in France and in vitro assessment of their susceptibility to antibiotics]
    H Dabernat
    Institut Fédératif de Biologie, Bactériologie Hygiène, Centre national de reference des Haemophilus influenzae, 330, avenue de Grande Bretagne, TSA 40031, 31059 Toulouse cedex 09, France
    Med Mal Infect 37:320-4. 2007
    ..The aim of this study was to describe the epidemiology of H. influenzae strains collected in 2004 at the National Reference Center and to evaluate their susceptibility to various antibiotics...
  58. ncbi Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women
    Mehmet Refik Bayraktar
    Department of Medical Microbiology, Faculty of Medicine, Inonu University, 44315 Malatya, Turkey
    Int J Infect Dis 14:e90-5. 2010
    ..We aimed to study the role of these pathogens in symptomatic and asymptomatic pregnant women and determine their clinical significance and antibiotic susceptibility...
  59. ncbi [Antibiotherapy for acute CAP in adults]
    E Denes
    Service de Maladies Infectieuses et Tropicales, CHU Dupuytren, 2, avenue Martin Luther King, 87042 Limoges Cedex, France
    Med Mal Infect 36:718-33. 2006
    ..on new antibiotics which can be used for this infection such as levofloxacin, moxifloxacin, telithromycin, and pristinamycin. All these drugs are effective on bacteria involved in pneumonia...
  60. ncbi [Vaginal colonization of the Streptococcus agalactiae in pregnant woman in Tunisia: risk factors and susceptibility of isolates to antibiotics]
    A Ferjani
    Laboratoire de miaobiologie et d immunologie, UR 16 02, CHU F Hached, Sousse 4001, Tunisie
    Bull Soc Pathol Exot 99:99-102. 2006
    ..4%), erythromycin (51.3%) and lincomycin (46.2%). All the strains were susceptible to amoxicilin and pristinamycin.
  61. ncbi [Hemorrhagic proctitis caused by Klebsiella oxytoca after administration of pristinamycin]
    E Rassiat
    Presse Med 31:1415. 2002
  62. ncbi [Impetigo]
    J Mazereeuw-Hautier
    Service de Dermatologie, Hopital Rangueil, 1, avenue Jean Poulhes, TSA 50032, 31059 Toulouse cedex 09
    Ann Dermatol Venereol 133:194-207. 2006
  63. ncbi Widespread activation of antibiotic biosynthesis by S-adenosylmethionine in streptomycetes
    Jung Hyun Huh
    Department of Biological Science, Institute of Bioscience and Biotechnology, Myongji University, Yongin 449 728, Korea
    FEMS Microbiol Lett 238:439-47. 2004
    ..b>Pristinamycin II(B) and granaticin do not require SAM-dependent methylation in their biosynthesis pathways, and production ..
  64. pmc In vitro selection and characterization of resistance to macrolides and related antibiotics in Mycoplasma pneumoniae
    S Pereyre
    Laboratoire de Bacteriologie, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex, France
    Antimicrob Agents Chemother 48:460-5. 2004
    ..antibiotics, erythromycin A, azithromycin, josamycin, clindamycin, quinupristin, quinupristin-dalfopristin, pristinamycin, and telithromycin...
  65. ncbi [Male gonococcal urethritis in the region of Sfax (1996-2000)]
    Abir Znazen
    Laboratoire de Microbiologie, CHU Habib Bourguiba Sfax
    Tunis Med 81:329-33. 2003
    ..2% of cases and the culture enabled us to isolate 72 strains, of which 15.5% were productive of beta-lactamase and 23.9% were resistant to tetracyclin. There was no resistance to pristinamycin, ofloxacin nor spectinomycin.
  66. ncbi Novel pristinamycin-responsive expression systems for plant cells
    A D Frey
    Institute of Biotechnology, Swiss Federal Institute of Technology, ETH Zurich, CH 8093 Zurich, Switzerland
    Biotechnol Bioeng 74:154-63. 2001
    Novel gene regulation systems were designed for plant cells responsive to the streptogramin antibiotic pristinamycin. The pristinamycin-repressible plant gene regulation concept (PIPpOFF) is based on a transcriptional activator (PIT) ..
  67. ncbi A transcriptional regulator of a pristinamycin resistance gene in Streptomyces coelicolor
    M Folcher
    Biozentrum, University of Basel, Department of Microbiology, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    J Biol Chem 276:1479-85. 2001
    Pip is a pristinamycin-induced transcriptional regulator protein detected in many Streptomyces species by its ability to specifically bind sequence motifs within the promoter of a Streptomyces pristinaespiralis multidrug resistance gene (..
  68. pmc Pharmacokinetics of quinupristin-dalfopristin in continuous ambulatory peritoneal dialysis patients
    C A Johnson
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53706, USA
    Antimicrob Agents Chemother 43:152-6. 1999
    ..areas under the curve, or half-lives for cysteine, the glutathione conjugates of quinupristin, or the pristinamycin IIA metabolite of dalfopristin...
  69. ncbi Antibiotic susceptibility and phage typing of methicillin-resistant and -sensitive Staphylococcus aureus clinical isolates at three periods during 1991-1997
    Z Samra
    Department of Microbiology, Rabin Medical Center, Petah Tiqva, Israel
    Eur J Clin Microbiol Infect Dis 20:425-7. 2001
    ..Over the study period, resistance to pristinamycin and fusidic acid increased slightly and resistance to imipenem, rifampicin and amikacin increased greatly, ..
  70. ncbi [A prospective study on erysipelas and infectious cellulitis: how are they dealt within hospital?]
    J L Schmit
    Service de Maladies Infectieuses, CHU, 80000 Amiens, France
    Ann Dermatol Venereol 128:334-7. 2001
    ..7 p. 100 of the cellulitis cases. Other antibiotics used were pristinamycin, antistaphylococcal penicillin, and amoxicillin. Combinations of antibiotics were used to treat 50 p...
  71. ncbi Microbiology of mandibular third molar pericoronitis: incidence of beta-lactamase-producing bacteria
    Jean Louis Sixou
    University of Rennes 1, Rannes, France
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:655-9. 2003
    ..The purpose of this study was to evaluate the predominant flora associated with pericoronitis in third molars and to investigate the presence of beta-lactamase-producing strains...
  72. pmc Oral pristinamycin versus standard penicillin regimen to treat erysipelas in adults: randomised, non-inferiority, open trial
    Philippe Bernard
    Department of Dermatology, Hopital Robert Debre, 51092 Reims, France
    BMJ 325:864. 2002
    To assess the efficacy and safety of oral pristinamycin versus intravenous then oral penicillin to treat erysipelas in patients in hospital.
  73. pmc Resistance to quinupristin-dalfopristin due to mutation of L22 ribosomal protein in Staphylococcus aureus
    Brigitte Malbruny
    Service de Microbiologie, CHU de Caen, Caen, France
    Antimicrob Agents Chemother 46:2200-7. 2002
    ..Synergistic ribosomal binding of streptogramins A and B, studied by analyzing the fluorescence kinetics of pristinamycin I(A)-ribosome complexes, was abolished in the mutant strain, providing an explanation for quinupristin-..
  74. ncbi [In vitro activity of pristinamycin against Streptococcus pneumoniae]
    J Maugein
    Laboratoire de Bacteriologie, Hopital Cardiologique du Haut Leveque, avenue de Magellan 33604 Pessac, France
    Pathol Biol (Paris) 49:583-6. 2001
    The activity of the pristinamycin was investigated using disk diffusion agar or ATB PNEUMO system and MIC determination using reference liquid medium method (NCCLS) on 749 S. pneumoniae strains isolated in Aquitaine in 1999...
  75. pmc Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA
    Mingfu Liu
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense M, Denmark
    Antimicrob Agents Chemother 46:1629-33. 2002
    ..resistance to the macrolides clarithromycin and erythromycin, and low resistance to the streptogramin B pristinamycin IA...
  76. ncbi Streptogramin-based gene regulation systems for mammalian cells
    M Fussenegger
    Institute of Biotechnology, Swiss Federal Institute of Technology, ETH Zurich, CH 8093 Zurich, Switzerland
    Nat Biotechnol 18:1203-8. 2000
    ..as inducible (PipON) systems for regulated gene expression in mammalian cells, based on the repressor Pip (pristinamycin-induced protein), which is encoded by the streptogramin resistance operon of Streptomyces coelicolor...
  77. ncbi Prevalence and antibiotic susceptibility of genital Mycoplasma hominis and Ureaplasma urealyticum in a university hospital in Turkey
    O Karabay
    Department of Infectious Diseases and Clinical Microbiology, Izzet Baysal Medical Faculty, Abant Izzet Baysal University, Bolu, Turkey
    Clin Exp Obstet Gynecol 33:36-8. 2006
    ..together with antimicrobial susceptibility to doxycycline, ciprofloxacin, ofloxacin, erythromycin, josamycin, pristinamycin, and tetracycline. Ureaplasma urealyticum was detected in 185 (48.4%) cultures, and M. hominis in 17 (4.4%)...
  78. ncbi Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells
    Beat P Kramer
    Institute of Biotechnology, Swiss Federal Institute of Technology, ETH Zurich, CH 8093 Zurich, Switzerland
    Biotechnol Bioeng 83:810-20. 2003
    ..expression in response to the macrolide erythromycin (+), and 4) complete repression by streptogramins such as pristinamycin (-)...
  79. ncbi Proteomic studies of diauxic lag in the differentiating prokaryote Streptomyces coelicolor reveal a regulatory network of stress-induced proteins and central metabolic enzymes
    Jana Novotna
    Institute of Microbiology CAS, Prague, Czech Republic
    Mol Microbiol 48:1289-303. 2003
    ..regulatory programme involving the sequential activation of heat-, salt-, cold- and bacteriostatic antibiotic (pristinamycin I, PI)-induced stimulons...
  80. pmc Dual-regulated expression of C/EBP-alpha and BMP-2 enables differential differentiation of C2C12 cells into adipocytes and osteoblasts
    Cornelia Fux
    Institute of Biotechnology, Swiss Federal Institute of Technology, ETH Hoenggerberg, HPT D74, CH 8093 Zurich, Switzerland
    Nucleic Acids Res 32:e1. 2004
    ..control of both differentiation factors using clinically licensed antibiotics of the streptogramin (pristinamycin) and tetracycline (tetracycline) classes...
  81. ncbi Characterization of virginiamycin S biosynthetic genes from Streptomyces virginiae
    Wises Namwat
    Department of Biotechnology, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Gene 286:283-90. 2002
    ..of nikkomycin D biosynthesis, VisB (66% identity, 72% similarity) to 3-hydroxypicolinic acid:AMP ligase of pristinamycin I biosynthesis, VisC (48% identity, 59% similarity) to lysine cyclodeaminase of ascomycin biosynthesis, and ..
  82. ncbi Antibiotic resistance and mechanisms implicated in clinical enterococci in a Tunisian hospital
    N Klibi
    Laboratoire de Microbiologie, Departement de Biologie, Faculté de Sciences de Tunis, Campus Universitaire, Tunisia
    J Chemother 18:20-6. 2006
    ..78/ 44/ 54%), chloramphenicol (52/ 29/ 27%), erythromycin (66/ 100/ 82%), spiramycin (84/ 83/ 64%), pristinamycin (100/ 0/ 73%), trimethoprim-sulfamethoxazole (88/ 78/ 91%), rifampicin (72/ 41/ 0%), vancomycin (0/ 0/ 36%), ..
  83. ncbi Antibacterial activity of Thymus maroccanus and Thymus broussonetii essential oils against nosocomial infection - bacteria and their synergistic potential with antibiotics
    Mariam Fadli
    Laboratoire de Biologie et Biotechnologie des Microorganismes, Pole d Excellence Regionale AUF, Faculté des Sciences Semlalia, Universite Cadi Ayyad, B P 2390, 40000 Marrakech, Morocco
    Phytomedicine 19:464-71. 2012
    ..Synergistic interactions between antibiotics (ciprofloxacin, gentamicin, pristinamycin, and cefixime) and EOs, and between T. maroccanus and T...
  84. ncbi Acute generalized exanthematous pustulosis
    Alexis Sidoroff
    Department of Dermatology and Venereology, Medical University of Innsbruck, Innsbruck, Austria
    Chem Immunol Allergy 97:139-48. 2012
    ..drugs, the ones with the highest risk being antibacterial agents like ampicillin/amoxicillin, and quinolones, pristinamycin, anti-infective sulfonamides, the antimycotic drug terbinafine, (hydroxy)chloroquine, and diltiazem...
  85. ncbi Epidemiology of cutaneous adverse drug reactions
    Maja Mockenhaupt
    Dokumentationszentrum schwerer Hautreaktionen, Department of Dermatology, University Freiburg Medical Center, Freiburg, Germany
    Chem Immunol Allergy 97:1-17. 2012
    ..In contrast, acute generalized exanthematous pustulosis is predominantly caused by the antibiotics pristinamycin and aminopenicillins, followed by quinolones, (hydroxy-)chloroquine and sulfonamides...
  86. ncbi Acute generalised exanthematous pustulosis
    Suran L Fernando
    Department of Clinical Immunology, Royal North Shore Hospital, PaLMS Immunorheumatology Laboratory and Northern Clinical School, Sydney University, Sydney, New South Wales, Australia
    Australas J Dermatol 53:87-92. 2012
    ..The drugs conferring the highest risk of AGEP according to the EuroSCAR study are aminopenicillins, pristinamycin, hydroxychloroquine, antibacterial sulphonamides, terbinafine and diltiazem...
  87. ncbi Drug Fever: a descriptive cohort study from the French national pharmacovigilance database
    Dominique Vodovar
    Department of Internal Medicine, AP HP, Ambroise Par Hospital, Boulogne Billancourt, France
    Drug Saf 35:759-67. 2012
    ..Only sparse data regarding DF have been published...
  88. ncbi [Osteoarticular infections: therapeutic proposals of the Paediatric Infectious Diseases Group of the French Society of Paediatrics (GPIP)]
    E Grimprel
    Groupe de pathologie infectieuse pédiatrique de la Société française de pédiatrie, Hopital Armand Trousseau, 26 av Dr Arnold Netter 75012 Paris, Universite Pierre et Marie Curie Paris VI, France
    Arch Pediatr 15:S74-80. 2008
    ....
  89. ncbi [In vitro sensitivity to antibiotics in 178 strains of genital mycoplasma isolated from gynecology consultants in Dakar]
    A I Sow
    Laboratoire de Bacteriologie, Dakar Fann, Senegal
    Bull Soc Pathol Exot 93:6-7. 2000
    ..Over 93% of U. urealyticum strains are susceptible to all the macrolids and apparented tested (erythromycin, pristinamycin, josamycin), but the activity of lincomycin, pristinamycin and josamycin on M...
  90. ncbi [Cutaneous ulcers and glycogen storage disease type 1b]
    E Le Bidre
    Service de Dermatologie, Hopital Trousseau, CHRU de Tours, Universite Francois Rabelais, avenue de la Republique, 37044 Tours cedex 9, France emmanuelle
    Ann Dermatol Venereol 137:377-80. 2010
    ....
  91. ncbi Pristinamycin as adjunctive therapy in the management of Gram-positive multi-drug resistant organism (MDRO) osteoarticular infection
    N Ruparelia
    Bone Infection Unit, Department of Infectious Diseases, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford OX3 7LD, UK
    J Infect 57:191-7. 2008
    ..We report our experience using pristinamycin, an oral streptogramin, when conventional antibiotics were poorly tolerated or inappropriate because of multi-..
  92. ncbi Novel streptogramin antibiotics
    G Bonfiglio
    Dipartimento di Scienze Microbiologiche, Universita di Catania, Via Androne 81, 95124 Catania, Italy
    Expert Opin Investig Drugs 10:185-98. 2001
    ..The synthesis of water-soluble derivatives of pristinamycin I(A) and II(B) has allowed the development of injectable, first represented by quinupristin/dalfopristin (..
  93. ncbi ATP hydrolysis and pristinamycin IIA inhibition of the Staphylococcus aureus Vga(A), a dual ABC protein involved in streptogramin A resistance
    Eric Jacquet
    Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, Gif sur Yvette, France
    J Biol Chem 283:25332-9. 2008
    ..Of great interest, Vga(A) ATPase was specifically inhibited in a non-competitive manner by the SgA substrate, pristinamycin IIA (PIIA)...
  94. ncbi [In vitro activity of miocamycin compared with four other macrolides and with pristinamycin against Branhamella catarrhalis]
    G Suermondt
    Laboratoire de Bacteriologie, Centre Hospitalier Universitaire, Amiens
    Pathol Biol (Paris) 37:386-9. 1989
    ..of miocamycin was compared with four other macrolides (erythromycin, roxithromycin, josamycin, spiramycin) and pristinamycin against 90 clinical isolates of Branhamella catarrhalis by determination of minimum inhibitory concentrations...
  95. pmc Emergence of pristinamycin resistance in India
    Shyam Sunder Keshari
    Department of Pharmacology and Microbiology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India
    Indian J Pharmacol 41:47-8. 2009
    ..septicemia, caused by the methicillin resistant Staphylococcus aureus (MRSA), showing primary in vitro pristinamycin resistance...
  96. ncbi Medium optimization based on statistical methodologies for pristinamycins production by Streptomyces pristinaespiralis
    B Jia
    Department of Biological and Pharmaceutical Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo 315100, People s Republic of China
    Appl Biochem Biotechnol 144:133-43. 2008
    ..95 and 5.67g/L, respectively. Under the optimized medium, the yield of pristinamycins in the shake flask and 5-L bioreactor could reach 1.30 and 1.01 g/L, respectively, which is the highest yield reported in literature to date...
  97. ncbi Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics
    W S Champney
    Department of Biochemistry and Molecular Biology, J H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Curr Microbiol 41:126-35. 2000
    ..spiramycin and tylosin, the lincosamides lincomycin and clindamycin, and 3 streptogramin B compounds pristinamycin I(A), virginiamycin S, and CP37277...
  98. ncbi A general strategy for the production of difficult-to-express inducer-dependent bacterial repressor proteins in Escherichia coli
    Erik H Christen
    Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland
    Protein Expr Purif 66:158-64. 2009
    ..of Escherichia coli BL21*, we demonstrate that the addition of the PIP-specific streptogramin antibiotic pristinamycin I neutralizes the growth-inhibiting effect and results in >100-fold increased PIP titers...
  99. ncbi Factors associated with emergence of pristinamycin-resistant Staphylococcus aureus in a dermatology department: a case-control study
    L Verneuil
    Service de Dermatologie, CHU Caen, F 14033 Caen, France
    Br J Dermatol 163:329-33. 2010
    b>Pristinamycin is used for the treatment of Staphylococcus aureus skin infection. Staphylococcus aureus pristinamycin resistance is usually low. The frequency of pristinamycin-resistant S...
  100. ncbi [Evolution of antibiotic-resistance Staphylococcus aureus in Saint Camille Medical Centre in Ouagadougou]
    S D Karou
    Centre de Recherche Biomoléculaire Pietro Annigoni CERBA, Ouagadougou, Burkina Faso
    Med Trop (Mars) 70:241-4. 2010
    ..Monitoring the antibiotic resistance of microorganisms in a specific geographic area can be useful in developing new approaches to first-intention antibiotherapy...
  101. pmc Development of a repressible mycobacterial promoter system based on two transcriptional repressors
    Francesca Boldrin
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli, 63 35100 Padova, Italy
    Nucleic Acids Res 38:e134. 2010
    ..slow-growing mycobacteria based on two chromosomally encoded repressors, dependent on tetracycline (TetR) and pristinamycin (Pip), respectively. This uniqueness results in high versatility and stringency...

Research Grants2

  1. INTERACTION OF ANTIBIOTICS WITH RIBOSOMAL RNA
    Alexander Mankin; Fiscal Year: 1999
    ..In particular, the pristinamycin-resistance mutation will be analyzed in order to better characterize the synergistic mode of action of ..
  2. ANTIBIOTIC INHIBITION OF BACTERIAL RIBOSOME FORMATION
    WILLIAM CHAMPNEY; Fiscal Year: 2002
    ..The findings from this work will help in assessing the effectiveness of existing antibiotics and in developing new compounds as antimicrobial agents. ..