cyclosporine

Summary

Summary: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).

Top Publications

  1. doi Effect of cyclosporine on reperfusion injury in acute myocardial infarction
    Christophe Piot
    Hopital Arnaud de Villeneuve, Montpellier, France
    N Engl J Med 359:473-81. 2008
  2. ncbi Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D
    Emy Basso
    Department of Biomedical Sciences and Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 280:18558-61. 2005
  3. pmc Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy
    Hye Eun Yoon
    Division of Nephrology, Department of Internal Medicine, Incheon St Mary s Hospital, College of Medicine, The Catholic University of Korea, Incheon, South Korea
    Nephrol Dial Transplant 26:800-13. 2011
  4. pmc Cyclosporin A inhibits the influenza virus replication through cyclophilin A-dependent and -independent pathways
    Xiaoling Liu
    Center for Molecular Virology, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e37277. 2012
  5. doi A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study)
    F Vincenti
    Kidney Transplant Service, University of California San Francisco, San Francisco, CA, USA
    Am J Transplant 10:535-46. 2010
  6. ncbi Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
    Koichi Watashi
    Laboratory of Human Tumor Viruses, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto, Japan
    Hepatology 38:1282-8. 2003
  7. doi Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus
    Varun Garg
    Clinical Trials and Medical Information, Vertex Pharmaceuticals Inc, Cambridge, MA 02139, USA
    Hepatology 54:20-7. 2011
  8. pmc Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and Rockefeller University, New York, New York 10021, USA
    J Virol 79:176-83. 2005
  9. pmc Cyclosporin A inhibits the replication of diverse coronaviruses
    Adriaan H de Wilde
    Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Gen Virol 92:2542-8. 2011
  10. pmc A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach
    Feng Yang
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS Pathog 6:e1001118. 2010

Detail Information

Publications353 found, 100 shown here

  1. doi Effect of cyclosporine on reperfusion injury in acute myocardial infarction
    Christophe Piot
    Hopital Arnaud de Villeneuve, Montpellier, France
    N Engl J Med 359:473-81. 2008
    Experimental evidence suggests that cyclosporine, which inhibits the opening of mitochondrial permeability-transition pores, attenuates lethal myocardial injury that occurs at the time of reperfusion...
  2. ncbi Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D
    Emy Basso
    Department of Biomedical Sciences and Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 280:18558-61. 2005
    ..These results have major implications for our current understanding of the PTP and its modulation in vitro and in vivo...
  3. pmc Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy
    Hye Eun Yoon
    Division of Nephrology, Department of Internal Medicine, Incheon St Mary s Hospital, College of Medicine, The Catholic University of Korea, Incheon, South Korea
    Nephrol Dial Transplant 26:800-13. 2011
    ..It is suggested that activation of renin-angiotensin system (RAS) or oxidative stress suppresses Klotho in the kidney. This study evaluated the association between Klotho expression and RAS in cyclosporine (CsA)-induced renal injury.
  4. pmc Cyclosporin A inhibits the influenza virus replication through cyclophilin A-dependent and -independent pathways
    Xiaoling Liu
    Center for Molecular Virology, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e37277. 2012
    ..Finally, CsA could enhance the binding between CypA and M1. The above results suggested that CsA inhibited the replication of influenza A virus through CypA-dependent and -independent pathways...
  5. doi A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study)
    F Vincenti
    Kidney Transplant Service, University of California San Francisco, San Francisco, CA, USA
    Am J Transplant 10:535-46. 2010
    ..Immunosuppression Trial) assessed a more intensive (MI) or less intensive (LI) regimen of belatacept versus cyclosporine in adults receiving a kidney transplant from living or standard criteria deceased donors...
  6. ncbi Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
    Koichi Watashi
    Laboratory of Human Tumor Viruses, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto, Japan
    Hepatology 38:1282-8. 2003
    ..This anti-HCV activity of CsA appeared to be independent of its immunosuppressive function. In conclusion, our results suggest that CsA may represent a new approach for the development of anti-HCV therapy...
  7. doi Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus
    Varun Garg
    Clinical Trials and Medical Information, Vertex Pharmaceuticals Inc, Cambridge, MA 02139, USA
    Hepatology 54:20-7. 2011
    ..inhibitor telaprevir is an inhibitor of the enzyme cytochrome P450 3A, responsible for the metabolism of both cyclosporine and tacrolimus...
  8. pmc Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells
    Theodora Hatziioannou
    Aaron Diamond AIDS Research Center and Rockefeller University, New York, New York 10021, USA
    J Virol 79:176-83. 2005
    ..Moreover, disruption of the CypA-CA interaction with cyclosporine A (CsA) inhibits HIV-1 infectivity only if the target cell expresses CypA...
  9. pmc Cyclosporin A inhibits the replication of diverse coronaviruses
    Adriaan H de Wilde
    Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Gen Virol 92:2542-8. 2011
    ....
  10. pmc A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach
    Feng Yang
    Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
    PLoS Pathog 6:e1001118. 2010
    ..selection scheme that identified a major viral determinant of HCV's dependence on CyPA and susceptibility to cyclosporine A...
  11. doi A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)
    A Durrbach
    Bicetre Hospital, Kremlin Bicetre, IFRNT, Universite Paris Sud, France
    Am J Transplant 10:547-57. 2010
    ..is a 3-year, Phase III study that assessed a more (MI) or less intensive (LI) regimen of belatacept versus cyclosporine in adult ECD kidney transplant recipients...
  12. doi Tacrolimus versus cyclosporine as primary immunosuppression after heart transplantation: systematic review with meta-analyses and trial sequential analyses of randomised trials
    Luit Penninga
    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Cochrane Hepato Biliary Group, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Eur J Clin Pharmacol 66:1177-87. 2010
    We conducted a systematic review of randomized trials to compare the benefits and harms of tacrolimus versus cyclosporine as primary immunosuppression after heart transplantation.
  13. ncbi Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine
    Steven G Simonson
    AstraZeneca, Wilmington, Del, USA
    Clin Pharmacol Ther 76:167-77. 2004
    b>Cyclosporine (INN, ciclosporin) increases the systemic exposure of all statins...
  14. ncbi Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency
    William A Irwin
    Department of Histology, University of Padova, 35121 Padova, Italy
    Nat Genet 35:367-71. 2003
    ..These findings indicate that collagen VI myopathies have an unexpected mitochondrial pathogenesis that could be exploited for therapeutic intervention...
  15. pmc NFATc1 balances quiescence and proliferation of skin stem cells
    Valerie Horsley
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 132:299-310. 2008
    ..Our findings may explain why patients receiving cyclosporine A for immunosuppressive therapy display excessive hair growth, and unveil a functional role for calcium-NFATc1-..
  16. ncbi Induction and long-term treatment with cyclosporine in membranous nephropathy with the nephrotic syndrome
    Efstathios Alexopoulos
    Department of Nephrology, Hippokration General Hospital, 49, Konstantinoupoleos str, 54642 Thessaloniki, Greece
    Nephrol Dial Transplant 21:3127-32. 2006
    b>Cyclosporine A (CyA) has been shown to be effective in membranous nephropathy (MN). However, the optimal dose and the duration of treatment remain controversial issues...
  17. pmc Cyclosporine A regulate oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via ROS generation, iNOS and Hsp70
    Huei Wen Chen
    Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
    Br J Pharmacol 137:771-81. 2002
    1. Previous study suggested that cyclosporine A (CsA) could partially reduce ischaemia/reperfusion-induced injury in isolated heart, but the mechanism was still unclear...
  18. ncbi Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction
    D Anglicheau
    INSERM, U775, Universite Rene Descartes, Paris, France
    Kidney Int 70:1019-25. 2006
    b>Cyclosporine nephrotoxicity remains a major side effect in solid organ transplantation, and can be exacerbated by concomitant administration of sirolimus. Cyclosporine and sirolimus are P-glycoprotein (Pgp) substrates...
  19. pmc Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine
    J H McIntosh
    Department of Haematology, UCL Cancer Institute, University College London, Oxford, UK
    Gene Ther 19:78-85. 2012
    The ability of transient immunosuppression with a combination of a non-depleting anti-CD4 (NDCD4) antibody and cyclosporine (CyA) to abrogate immune reactivity to both adeno-associated viral vector (AAV) and its transgene product was ..
  20. pmc Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity
    Zuzana Keckesova
    Department of Infection, Royal Free and University College Medical School, University College London, Windeyer Building, 46 Cleveland Street, London W1T4JF, United Kingdom
    J Virol 80:4683-90. 2006
    ..Inhibition of cyclophilin A activity with cyclosporine A, or reducing cyclophilin A expression with small interfering RNA, rescues TRIM5alpha-restricted HIV-1 ..
  21. ncbi Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    N A Clipstone
    Beckman Center for Molecular and Genetic Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305
    Nature 357:695-7. 1992
    ....
  22. pmc Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity
    Elena Sokolskaja
    Department of Microbiology, Columbia University, 701 W 168th St, New York, NY 10032, USA
    J Virol 78:12800-8. 2004
    ..Disruption of the CA-CypA interaction, either by the competitive inhibitor cyclosporine (CsA) or by mutation of CA residue G89 or P90, suggested that producer cell CypA was required for full virion ..
  23. ncbi Cyclosporine A delivery to the eye: a pharmaceutical challenge
    F Lallemand
    School of Pharmacy, University of Geneva, Geneva, Switzerland
    Eur J Pharm Biopharm 56:307-18. 2003
    Systemic administration of cyclosporine A (CsA) is commonly used in the treatment of local ophthalmic conditions involving cytokines, such as corneal graft rejection, autoimmune uveitis and dry eye syndrome...
  24. pmc Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation
    Emy Basso
    Department of Biomedical Sciences and Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 283:26307-11. 2008
    ..These findings call for a reassessment of conclusions on the role of the PTP in cell death that are based on the effects of CsA or of CyP-D ablation...
  25. pmc The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition
    Anna W C Leung
    Department of Biochemistry and The Bristol Heart Institute, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 283:26312-23. 2008
    ..An interaction of the PiC with the ANT may enable agents that bind to either transporter to modulate pore opening...
  26. ncbi Macrophage activation syndrome
    Angelo Ravelli
    Pediatria II, Istituto G Gaslini, Universita di Genova, Italy
    Curr Opin Rheumatol 14:548-52. 2002
    ..Cyclosporin A has been found effective in patients with corticosteroid-resistant MAS. A recent report has suggested that etanercept may be a useful adjunctive therapeutic agent...
  27. pmc Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A
    Fiona Fernandes
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 5:e9815. 2010
    ..The immunosuppressant, cyclosporine A (CsA) has potent anti-HCV activity towards both HCV replicons and the genotype 2a cell culture infectious ..
  28. doi In vitro effects of cyclosporine A and tacrolimus on regulatory T-cell proliferation and function
    Céline Miroux
    CNRS UMR8161, Institut de Biologie de Lille, Universités Lille Nord de France, Lille, France
    Transplantation 94:123-31. 2012
    ..Regulatory T cells (Tregs) may be beneficial in tolerance but deleterious in recurrent hepatitis C. We evaluated the effects of cyclosporine or tacrolimus, the principal immunosuppressive drugs, on Treg proliferation and function.
  29. doi Efficacy and safety of early cyclosporine conversion to sirolimus with continued MMF-four-year results of the Postconcept study
    Y Lebranchu
    Department of Nephrology, Clinical Immunology, University Hospital, Francois Rabelais University, Tours, France
    Am J Transplant 11:1665-75. 2011
    ..We previously reported that conversion from cyclosporine A (CsA) to sirolimus (SRL) 3 months after transplantation significantly improved renal function at 1 year...
  30. ncbi Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1
    Matthew Stremlau
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
    Virology 351:112-20. 2006
    ..Inhibition of Cyp A function by cyclosporine significantly decreased the efficiency of TRIM5alpha-mediated restriction only when the restricted virus capsid ..
  31. pmc Spontaneous mutations in the human immunodeficiency virus type 1 gag gene that affect viral replication in the presence of cyclosporins
    C Aberham
    Sandoz Forschungsinstitut, Vienna, Austria
    J Virol 70:3536-44. 1996
    ..In at least one isolate examined, the revertant phenotype appears to be due to suppressor mutations near the proline-rich region...
  32. doi Development and characterization of Cyclosporine A loaded nanoparticles for ocular drug delivery: Cellular toxicity, uptake, and kinetic studies
    Pelin Aksungur
    Faculty of Pharmacy, Department of Pharmaceutical Technology, Hacettepe University, 06100 Ankara, Turkey
    J Control Release 151:286-94. 2011
    ..The objective of this study was to evaluate the potential effectiveness of Cyclosporine A (CsA) nanoparticles (NPs) for the treatment of inflammation of the eye surface...
  33. doi Effect of sirolimus on calcineurin inhibitor-induced nephrotoxicity using renal expression of KLOTHO, an antiaging gene
    Dong He Han
    Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea
    Transplantation 90:135-41. 2010
    ..METHODS.: Mice were treated with vehicle (VH; 1 mL/kg/day of olive oil), cyclosporine A (CsA; 30 mg/kg/day), or tacrolimus (FK; 1 mg/kg/day) with or without SRL (0.3 mg/kg/day) for 2 weeks...
  34. ncbi Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis
    Miao Ying Lai
    Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan, ROC
    Planta Med 70:132-7. 2004
    ..In order to investigate the effect of SR on the absorption and disposition of cyclosporine, rats were administered with cyclosporine orally (in the form of the microemulsion Neoral and intravenously ..
  35. ncbi Pharmacokinetics and clinical efficacy of cyclosporine treatment of dogs with steroid-refractory inflammatory bowel disease
    K Allenspach
    Department of Veterinary Clinical Medicine, Vetsuisse Faculty, University of Bern, Switzerland
    J Vet Intern Med 20:239-44. 2006
    ..Because cyclosporine A (cyA) has been shown to be effective in steroid-resistant IBD in humans, the purpose of this study was to ..
  36. doi Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis
    Eleonora Patsenker
    Institute of Clinical Pharmacology and Visceral Research, University of Bern, Switzerland
    J Hepatol 55:388-98. 2011
    ..The aim of the present study was to compare the potential of the commonly used immunosuppressants to halt experimental liver fibrosis progression...
  37. ncbi Development of biodegradable nanoparticles for oral delivery of ellagic acid and evaluation of their antioxidant efficacy against cyclosporine A-induced nephrotoxicity in rats
    K Sonaje
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, SAS Nagar, Mohali, Punjab, 160062, India
    Pharm Res 24:899-908. 2007
    ..Ellagic acid (EA), a dietary antioxidant associated with poor biopharmaceutical properties, was encapsulated into poly(lactide-co-glycolide) (PLGA) and polycaprolactone (PCL) nanoparticles to improve oral bioavailability...
  38. pmc NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells
    Erik Ullerås
    Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Blood 111:3081-9. 2008
    ..These results indicate that, in FcepsilonRI stimulated mast cells, A1 is transcriptionally regulated by NFAT1 but not by NF-kappaB...
  39. pmc HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors
    Udayan Chatterji
    The Scripps Research Institute, La Jolla, USA
    J Hepatol 53:50-6. 2010
    The cyclophilin (Cyp) inhibitors - cyclosporine A (CsA), NIM811, Debio 025, and SCY 635 - block HCV replication both in vitro and in vivo, and represent a novel class of potent anti-HCV agents...
  40. ncbi Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus
    F Vincenti
    University of California San Francisco Kidney Transplant Service, San Francisco, CA, USA
    Am J Transplant 7:1506-14. 2007
    ..De novo renal transplant patients were randomized to cyclosporine microemulsion (CsA-ME, using C(2) monitoring) or tacrolimus, with mycophenolic acid, steroids and basiliximab...
  41. pmc Cyclosporine for ocular inflammatory diseases
    R Oktay Kaçmaz
    Department of Ophthalmology, The Mount Sinai School of Medicine, New York, New York, USA
    Ophthalmology 117:576-84. 2010
    To evaluate the clinical outcomes of cyclosporine treatment for noninfectious ocular inflammation.
  42. doi Effect of cyclosporine on left ventricular remodeling after reperfused myocardial infarction
    Nathan Mewton
    Hospices Civils de Lyon, Universite Claude Bernard Lyon, Lyon, France
    J Am Coll Cardiol 55:1200-5. 2010
    This study examined the effect of a single dose of cyclosporine administered at the time of reperfusion on left ventricular (LV) remodeling and function by cardiac magnetic resonance 5 days and 6 months after myocardial infarction.
  43. doi Topical loteprednol pretreatment reduces cyclosporine stinging in chronic dry eye disease
    John D Sheppard
    Virginia Eye Consultants and the Department of Ophthalmology, Eastern Virginia Medical School, Norfolk, Virginia 23502, USA
    J Ocul Pharmacol Ther 27:23-7. 2011
    ..tolerability between those patients who receive topical corticosteroids prior to initiation of topical cyclosporine 0...
  44. ncbi Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors
    Greg J Towers
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nat Med 9:1138-43. 2003
    ..Manipulation of HIV-1 CA recognition by restriction factors promises to advance animal models and new therapeutic strategies for HIV-1 and AIDS...
  45. ncbi Randomized controlled trial of the efficacy of cyclosporine in the treatment of atopic dermatitis in dogs
    Thierry Olivry
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    J Am Vet Med Assoc 221:370-7. 2002
    To evaluate efficacy of cyclosporine A, administered at either of 2 dosages, in dogs with atopic dermatitis (AD).
  46. pmc Calcineurin regulates innate antifungal immunity in neutrophils
    Matthew B Greenblatt
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 207:923-31. 2010
    Patients taking immunosuppressive drugs, like cyclosporine A (CsA), that inhibit calcineurin are highly susceptible to disseminated fungal infections, although it is unclear how these drugs suppress resistance to these opportunistic ..
  47. pmc Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy
    Douglas P Millay
    Department of Pediatrics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Nat Med 14:442-7. 2008
    ..Thus, mitochondrial-dependent necrosis represents a prominent disease mechanism in muscular dystrophy, suggesting that inhibition of cyclophilin D could provide a new pharmacologic treatment strategy for these diseases...
  48. ncbi Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction
    Daniel C Brennan
    Washington University School of Medicine, Department of Internal Medicine, St Louis, Missouri, USA
    Am J Transplant 5:582-94. 2005
    ..Our purposes were to determine the incidence of BK viruria, viremia or nephropathy with tacrolimus (FK506) versus cyclosporine (CyA) and whether intensive monitoring and discontinuation of mycophenolate (MMF) or azathioprine (AZA), upon ..
  49. ncbi Cyclosporine in patients with steroid-resistant membranous nephropathy: a randomized trial
    D C Cattran
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 59:1484-90. 2001
    A clinical trial of cyclosporine in patients with steroid-resistant membranous nephropathy (MGN) was conducted. Although MGN remains the most common cause of adult-onset nephrotic syndrome, its management is still controversial...
  50. ncbi Cyclosporine A and adverse effects on organs: histochemical studies
    Rita Rezzani
    Anatomy Section, Department of Biomedical Sciences and Biotechnology, Viale Europa, 11, Brescia 25123, Italy
    Prog Histochem Cytochem 39:85-128. 2004
    The discovery that cyclosporine A (CsA) was a powerful immunosuppressant had a significant impact on transplant medicine...
  51. pmc DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A
    Lotte Coelmont
    Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    PLoS ONE 5:e13687. 2010
    ..Cross-resistance with cyclosporine A (CsA) was observed, whereas NS3 protease and NS5B polymerase inhibitors retained WT-activity against DEB025(..
  52. pmc The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
    Christian Faul
    Department of Medicine, University of Miami Miller School of Medicine, 1600 Northwest Tenth Avenue, Miami, Florida 33136, USA
    Nat Med 14:931-8. 2008
    The immunosuppressive action of the calcineurin inhibitor cyclosporine A (CsA) stems from the inhibition of nuclear factor of activated T cells (NFAT) signaling in T cells. CsA is also used for the treatment of proteinuric kidney diseases...
  53. pmc Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A
    D Braaten
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York 10032, USA
    J Virol 70:5170-6. 1996
    ..b>Cyclosporine A and nonimmunosuppressive analogs bind with high affinity to cyclophilin A, compete with Gag for binding to ..
  54. pmc A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA
    Ruifeng Yang
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, A 5301 Medical Center North, Nashville, TN 37232 2363, USA
    J Virol 81:3749-56. 2007
    ..The immunosuppressive drug cyclosporine A (CsA) and its nonimmunosuppressive analogs bind with high affinity to CypA and inhibit HIV-1 replication...
  55. ncbi Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
    J Aramburu
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 285:2129-33. 1999
    ..Compounds that interfere selectively with the calcineurin-NFAT interaction without affecting calcineurin phosphatase activity may be useful as therapeutic agents that are less toxic than current drugs...
  56. ncbi Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury
    Laurent Argaud
    INSERM E 0226, Laboratoire de Physiologie Lyon Nord, Faculté de Médecine Lyon Nord, Universite Claude Bernard Lyon I, 8, avenue Rockefeller, 69373 Lyon Cedex 8, France
    J Mol Cell Cardiol 38:367-74. 2005
    ..These data indicate that specific inhibition of MPT pore opening at reperfusion following acute myocardial infarction provides a powerful antinecrotic and antiapoptotic protection...
  57. pmc Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses
    D Braaten
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Virol 70:4220-7. 1996
    ..Disruption of cyclophilin A incorporation, either by gag mutations or by cyclosporine A, inhibits virion infectivity, indicating that cyclophilin A plays an essential role in the HIV-1 life cycle...
  58. ncbi Sirolimus therapy after early cyclosporine withdrawal reduces the risk for cancer in adult renal transplantation
    Josep M Campistol
    Hospital Clinic i Provincial, Barcelona, Spain
    J Am Soc Nephrol 17:581-9. 2006
    Sirolimus (SRL) is a mammalian target of rapamycin inhibitor that, in contrast to cyclosporine (CsA), has been shown to inhibit rather than promote cancers in experimental models...
  59. pmc Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein
    Min Qing
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    Antimicrob Agents Chemother 53:3226-35. 2009
    ..Furthermore, antiviral experiments demonstrated that cyclosporine (Cs; an 11-amino-acid cyclic peptide known to block the PPIase activity of CyPA) inhibits flavivirus ..
  60. doi Belatacept-based regimens versus a cyclosporine A-based regimen in kidney transplant recipients: 2-year results from the BENEFIT and BENEFIT-EXT studies
    Christian P Larsen
    Emory Transplant Center and Department of Surgery, Emory University, Atlanta, GA, USA
    Transplantation 90:1528-35. 2010
    ..patient/graft survival, better renal function, and an improved cardiovascular/metabolic risk profile versus cyclosporine A (CsA) in the Belatacept Evaluation of Nephroprotection and Efficacy as Firstline Immunosuppression Trial (..
  61. pmc Combination of cyclosporine and erythropoietin improves brain infarct size and neurological function in rats after ischemic stroke
    Chun Man Yuen
    Division of Trauma, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    J Transl Med 9:141. 2011
    This study tested the superiority of combined cyclosporine A (CsA)-erythropoietin (EPO) therapy compared with either one in limiting brain infarction area (BIA) and preserving neurological function in rat after ischemic stroke (IS).
  62. ncbi A three-arm study comparing immediate tacrolimus therapy with antithymocyte globulin induction therapy followed by tacrolimus or cyclosporine A in adult renal transplant recipients
    Bernard Charpentier
    Service de Nephrologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    Transplantation 75:844-51. 2003
    ..A study was undertaken to assess the efficacy and safety of ATG induction on tacrolimus-based and cyclosporine A (CsA)-based therapies compared with immediate tacrolimus triple therapy in kidney transplant recipients.
  63. pmc Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist
    Shirin Bruderer
    Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland
    AAPS J 14:68-78. 2012
    ..We investigated the effect of cyclosporine (Cs) and rifampin on the pharmacokinetics of macitentan and its metabolites ACT-132577 and ACT-373898 in ..
  64. doi GSK3, snail, and adhesion molecule regulation by cyclosporine A in renal tubular cells
    Sergio Berzal
    Division of Nephrology and Hypertension, Laboratory of Nephrology and Vascular Pathology, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Autonoma de Madrid, 28040 Madrid, Spain
    Toxicol Sci 127:425-37. 2012
    ..In renal tubular cells, cytotoxic concentrations of cyclosporine A (CsA) inhibited both gene and protein expression of adherent and tight junction proteins (E-cadherin, ZO-1, ..
  65. doi Clinical review: topical ophthalmic use of cyclosporin A
    Canan Asli Utine
    The Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Ocul Immunol Inflamm 18:352-61. 2010
    b>Cyclosporine A (CsA) is an immunomodulatory agent that primarily inhibits the proliferation and action of T cells. Systemic CsA has been used successfully in solid organ transplantation and noninfectious uveitis...
  66. doi Calcineurin inhibitor nephrotoxicity
    Maarten Naesens
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Clin J Am Soc Nephrol 4:481-508. 2009
    The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in the field of transplantation, with excellent short-term outcome...
  67. doi Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis
    Thierry Olivry
    Department of Clinical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Vet Dermatol 21:233-48. 2010
    ..Allergen-specific immunotherapy should be offered, whenever feasible, in an attempt to prevent recurrence of clinical signs upon further exposure to environmental allergens to which the patient is hypersensitive...
  68. pmc A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes
    Henry Dube
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 441:901-7. 2012
    ..These data indicate the potential value of selective CyP-D inhibition in cytoprotection...
  69. ncbi Tacrolimus or cyclosporine: which is the better partner for mycophenolate mofetil in heart transplant recipients?
    Bruno M Meiser
    Department of Cardiac Surgery, University of Munich, Grosshadern Medical Center, Marchioninistrasse 15, 81366 Munich, Germany
    Transplantation 78:591-8. 2004
    ..this single-center study was to investigate whether trough level adjusted mycophenolate mofetil (MMF) is more efficacious in combination with tacrolimus (TAC) or cyclosporine (CsA) and to evaluate the impact of either drug on MMF dosage.
  70. pmc Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A
    An Chi Wei
    Department of Biomedical Engineering, Institute of Computational Medicine, The Johns Hopkins University, Baltimore MD 21205 2195, USA
    Biochim Biophys Acta 1813:1373-81. 2011
    ..absence of inhibitors of mitochondrial Na(+)/Ca(2+) exchanger (CGP 37157) or the permeability transition pore (cyclosporine A)...
  71. ncbi Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce dura
    Dietger Niederwieser
    Division of Hematology and Oncology, University of Leipzig, Germany
    Blood 101:1620-9. 2003
    ..Patients were treated with fludarabine 30 mg/m(2)/d from days -4 to -2, 2 Gy total body irradiation on day 0, cyclosporine at 6.25 mg/kg twice daily from day -3, and mycophenolate mofetil at 15 mg/kg twice daily from day 0...
  72. doi Donor-specific HLA antibodies in a cohort comparing everolimus with cyclosporine after kidney transplantation
    L Liefeldt
    Department of Nephrology, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Transplant 12:1192-8. 2012
    ..At 3-4.5 months posttransplant 127 patients were randomized to continue cyclosporine or converted to everolimus therapy. The presence of DSA was prospectively assessed using Luminex assays...
  73. pmc Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure
    Shiang Y Lim
    The Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, UK
    J Cell Mol Med 15:2443-51. 2011
    ..These findings suggest that the inhibition of mitochondrial CypD may be a novel therapeutic treatment strategy for post-MI heart failure...
  74. doi Long-term treatment of sirolimus but not cyclosporine ameliorates diabetic nephropathy in the rat
    Sandra Wittmann
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    Transplantation 87:1290-9. 2009
    ..We evaluated whether sirolimus (SRL) or cyclosporine A (CsA) therapy would be a superior immunosuppressant in streptozotocin-induced diabetic nephropathy.
  75. doi Malignancy concerns with psoriasis treatments using phototherapy, methotrexate, cyclosporin, and biologics: facts and controversies
    Luigi Naldi
    Centro Studi Gruppo Italiano Studi Epidemiologici in Dermatologia and Department of Dermatology, Largo Barozzi 1, Ospedali Riuniti, 24100 Bergamo, Italy
    Clin Dermatol 28:88-92. 2010
    ..More recently, an increased risk of cancer has been a concern with newly introduced biologic agents. The documentation of such a purported increased risk requires long-term follow-up of treated patients...
  76. ncbi Association of CYP3A4*18B polymorphisms with the pharmacokinetics of cyclosporine in healthy subjects
    Y F Hu
    Pharmacogenetics Research Institute, Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, People s Republic of China
    Xenobiotica 37:315-27. 2007
    The aim of this study is to evaluate the association of the CYP3A4*18B genotype with the cyclosporine metabolism in healthy subjects. We employed PCR-RFLP assays for analysis of the CYP3A4*18B genotype...
  77. doi Intraparenchymal injection of bone marrow mesenchymal stem cells reduces kidney fibrosis after ischemia-reperfusion in cyclosporine-immunosuppressed rats
    C Alfarano
    INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases I2MC, Toulouse, France
    Cell Transplant 21:2009-19. 2012
    ..After IR, rats were treated daily with cyclosporine (10 mg/kg SC) for 28 days. MSCs were injected into the kidney at day 7 after IR...
  78. doi The protective effect of epicatchin against oxidative stress and nephrotoxicity in rats induced by cyclosporine
    Abdulrahman L Al-Malki
    Biochemistry Department, Faculty of Science, King Abdualziz University, Jeddah, KSA
    Hum Exp Toxicol 30:145-51. 2011
    b>Cyclosporine A (CyA) is the first-line immunosuppressant used for the management of solid organ transplantation and autoimmune diseases. Reactive oxygen species (ROS) can attack all types of macromolecules including DNA and damage it...
  79. ncbi Incidence and cost of new onset diabetes mellitus among U.S. wait-listed and transplanted renal allograft recipients
    Robert S Woodward
    Department of Health Management and Policy, University of New Hampshire, Durham, NH, USA
    Am J Transplant 3:590-8. 2003
    ..NODM over the first 2 years post-transplant had an incidence of almost 18% and 30% among patients receiving cyclosporine and tacrolimus, respectively...
  80. doi Extended cyclosporine delivery by silicone-hydrogel contact lenses
    Cheng Chun Peng
    Department of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA
    J Control Release 154:267-74. 2011
    b>Cyclosporine A (CyA) is effective in treating chronic dry eyes and contact lens mediated dry eyes...
  81. ncbi Cyclosporin A pharmacokinetics and efficacy in the treatment of atopic dermatitis in dogs
    J Steffan
    Novartis Animal Health, WRO 1032 2 50, CH 4002 Basle, Switzerland
    J Vet Pharmacol Ther 27:231-8. 2004
    ....
  82. ncbi Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus
    K A Jørgensen
    Research Laboratory, Department of Renal Medicine C, Skejby Sygehus, Arhus University Hospital, Arhus N, Denmark
    Scand J Immunol 57:93-8. 2003
    ..Great variations in the correlation between blood drug levels and enzyme inhibition could indicate that monitoring calcineurin phosphatase activity for treatment might be superior to monitoring blood drug levels...
  83. doi Impact of cyclosporine-A concentration on the incidence of severe acute graft-versus-host disease after allogeneic stem cell transplantation
    Florent Malard
    Centre Hospitalier et Universitaire CHU de Nantes, Service d Hematologie Clinique, Nantes, France
    Biol Blood Marrow Transplant 16:28-34. 2010
    ..stem cell transplantation (allo-SCT) with the aim to assess whether there is a correlation between exposure to cyclosporine-A (CsA; as measured by CsA concentrations during the first month after allo-SCT) and the risk for developing ..
  84. pmc The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulations
    Hongbo Wang
    Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, USA
    Blood 110:1530-9. 2007
    ..Collectively, these studies show that CSA influences NK-cell function and phenotype, which may have important implications for graft-versus-leukemia effects...
  85. doi Cyclosporine and psoriasis: 2008 National Psoriasis Foundation Consensus Conference
    David M Rosmarin
    Department of Dermatology at Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
    J Am Acad Dermatol 62:838-53. 2010
    b>Cyclosporine is a valuable option for the treatment of psoriasis. This report summarizes studies regarding the use of cyclosporine since the last guidelines were published in 1998.
  86. pmc The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/- myopathic mice
    T Tiepolo
    Department of Histology, University of Padova, I 35121 Padova, Italy
    Br J Pharmacol 157:1045-52. 2009
    ..We have investigated the therapeutic effects of the selective cyclophilin inhibitor D-MeAla(3)-EtVal(4)-cyclosporin (Debio 025) in myopathic Col6a1(-/-) mice, a model of muscular dystrophies due to defects of collagen VI...
  87. pmc Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation
    Sylvanie Malouitre
    Research Department of Structural and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 425:137-48. 2010
    ..Moreover, the therapeutic potential of CsA against ischaemia/reperfusion injuries not involving glutamate may be improved by mitochondrial targeting...
  88. doi Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients
    Pål Falck
    Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway
    Transplantation 85:179-84. 2008
    We investigated cyclosporine A (CsA) concentrations at the site of action, inside T-lymphocytes, to evaluate its applicability as a new supplementary therapeutic drug monitoring method after renal transplantation.
  89. doi Influence of sirolimus on cyclosporine-induced pancreas islet dysfunction in rats
    H K Song
    Transplant Research Center, Division of Nephrology, Seoul St Mary s Hospital, The Catholic University of Korea, Seoul, Korea
    Am J Transplant 9:2024-33. 2009
    This study was performed to investigate the effect of sirolimus (SRL) on cyclosporine (CsA)-induced pancreatic islet dysfunction in rats. Three separate studies were performed...
  90. pmc A conserved tandem cyclophilin-binding site in hepatitis C virus nonstructural protein 5A regulates Alisporivir susceptibility
    Henry Grise
    Department of Biological Science, Florida State University, Tallahassee, Florida, USA
    J Virol 86:4811-22. 2012
    ..Together, these data provide a high-resolution mapping of proline residues important for CyPA binding and identify critical amino acids modulating HCV susceptibility to the clinical CPI Alisporivir...
  91. pmc Imaging of cyclosporine inhibition of P-glycoprotein activity using 11C-verapamil in the brain: studies of healthy humans
    Mark Muzi
    Department of Radiology, University of Washington, Seattle, Washington 98195 6004, USA
    J Nucl Med 50:1267-75. 2009
    ..BBB using PET of (11)C-verapamil distribution into the brain in the absence and presence of the P-gp inhibitor cyclosporine-A (CsA)...
  92. doi Calcineurin inhibitor minimization in the Symphony study: observational results 3 years after transplantation
    H Ekberg
    Lund University, Malmo, Sweden
    Am J Transplant 9:1876-85. 2009
    ..and lower acute rejection and graft loss rates compared with three other regimens: two with low-doses of cyclosporine or sirolimus instead of tacrolimus and one with no induction and standard cyclosporine dosage...
  93. doi Efficacy and safety of rituximab second-line therapy for membranous nephropathy: a prospective, matched-cohort study
    Paolo Cravedi
    Mario Negri Institute for Pharmacological Research, Bergamo, Italy
    Am J Nephrol 33:461-8. 2011
    ..Here we evaluated whether rituximab is equally effective in patients who failed to respond to previous immunosuppressive treatment...
  94. doi Topical ophthalmic cyclosporine: pharmacology and clinical uses
    Eric Donnenfeld
    Ophthalmic Consultants of Long Island and Connecticut, Rockville Centre, New York 11570, USA
    Surv Ophthalmol 54:321-38. 2009
    b>Cyclosporine has been used successfully as a systemic immunomodulator for more than two decades, and numerous studies have investigated its mechanisms of action. In 2003 an ophthalmic formulation, cyclosporine 0...
  95. pmc NIM811 (N-methyl-4-isoleucine cyclosporine), a mitochondrial permeability transition inhibitor, attenuates cholestatic liver injury but not fibrosis in mice
    Hasibur Rehman
    Department of Pharmaceutical and Biomedical, Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    J Pharmacol Exp Ther 327:699-706. 2008
    ..This study investigated whether NIM811 (N-methyl-4-isoleucine cyclosporine), an inhibitor of the mitochondrial permeability transition (MPT), attenuates cholestatic liver injury in vivo...
  96. doi Cyclosporine A attenuates hypoxic-ischemic brain injury in newborn rats
    Jong Hee Hwang
    Department of Pediatrics, Ilsan Paik Hospital, College of Medicine, Inje University, Ilsan, Republic of Korea
    Brain Res 1359:208-15. 2010
    b>Cyclosporine A (CsA) is neuroprotective in ischemic brain injuries of adult animals because it blocks the permeability transition of the mitochondrial membrane...
  97. doi Topical cyclosporine in thyroid orbitopathy-related dry eye: clinical findings, conjunctival epithelial apoptosis, and MMP-9 expression
    Canan Gürdal
    Ankara Ataturk Training and Research Hospital, 2nd Ophthalmology Department, Ankara, Turkey
    Curr Eye Res 35:771-7. 2010
    To evaluate the effects of topical cyclosporine A (CsA) 0.05% (Restasis) on the signs and symptoms of dry eye, on apoptosis, and on MMP-9 expression in conjunctiva epithelial cells in thyroid orbitopathy (TO)-related dry eye patients.
  98. doi Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients
    Severine Crettol
    Unit of Biochemistry and Clinical Psychopharmacology, Centre of Psychiatric Neuroscience, Department of Psychiatry, CHUV, University of Lausanne, Hospital of Cery, Prilly, Switzerland
    Pharmacogenet Genomics 18:307-15. 2008
    The expression on lymphocytes of P-glycoprotein, an efflux transporter encoded by the ABCB1 gene, might influence cyclosporine intracellular concentration.
  99. ncbi Evaluation of the anti-hepatitis C virus effects of cyclophilin inhibitors, cyclosporin A, and NIM811
    Kaku Goto
    Laboratory of Human Tumor Viruses, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 343:879-84. 2006
    ..Both CyP inhibitors rapidly reduced HCV RNA levels even further in combination with IFNalpha without modifying the IFNalpha signal transduction pathway. In conclusion, CyP inhibitors may provide a novel strategy for anti-HCV treatment...
  100. doi Ophthalmic delivery of cyclosporine A by punctal plugs
    Chhavi Gupta
    Chemical Engineering Department, University of Florida, Gainesville, FL 32611 6005, USA
    J Control Release 150:70-6. 2011
    Dry eyes are treated by instillation of eye drops of cyclosporine A emulsion or by punctal plug insertion in canaliculus to block tear drainage...
  101. pmc Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure
    Victor G Sharov
    Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, Michigan 48202, USA
    J Mol Cell Cardiol 42:150-8. 2007
    ..b>Cyclosporine A significantly slowed the exit of calcein from mitochondria of failing cardiomyocytes and increased ..

Research Grants70

  1. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..In this screen we included known compounds such as calcineurin inhibitors (Cyclosporine A), FK-506, and rapamycin, which are known suppressors of T-cell function...
  2. Molecular Mechanism of Immune Therapy for Bone Marrow Failures
    Pearlie K Epling-Burnette; Fiscal Year: 2013
    ..with immunosuppressive therapy (IST) such as low-dose methotrexate (MTX), low- dose cyclophosphamide (CY) or cyclosporine A (CyA) and, in the case of aplastic anemia and MDS, T cell depletion with anti-thymocyte globulin (ATG)...
  3. Dysfunctional PGC-1alpha expression in skeletal muscle during diabetes
    S Russ Price; Fiscal Year: 2013
    ..e., cyclosporine A, FK506)...
  4. Depot calcineurin inhibitors to prevent graft rejection
    Thomas J Smith; Fiscal Year: 2010
    ..Substantial inter-and intra-patient variability of the calcineurin inhibitors cyclosporine A (CsA) and tacrolimus (Tac) means that even frequent drug monitoring cannot eradicate rejection due to sub- ..
  5. A Clinical Trial to Prevent New Onset Diabetes After Transplantation
    Akinlolu O Ojo; Fiscal Year: 2013
    ..insulin resistance and hepatic gluconeogenesis;(3) direct beta-cell injury by the calcineurin inhibitor (cyclosporine or tacrolimus) and;(4) increased dietary caloric load secondary to the abrogation of chronic uremia-related ..
  6. L-arginine supplement for the prevention of calcineurin inhibitor nephrotoxicity
    W Ray Kim; Fiscal Year: 2011
    ..Post-LTx renal insufficiency is most commonly a result of long term exposure to calcineurin inhibitors, namely cyclosporine and tacrolimus, used to prevent and treat rejection...
  7. The role of intracellular trafficking pathways in calcium signaling
    Suzette Farber-Katz; Fiscal Year: 2013
    ..The characterization of these proteins will lead to the elucidation of novel pathways that control calcium signaling. ..
  8. Role of the Unfolded Protein Response in Beta Cell
    Randal J Kaufman; Fiscal Year: 2013
    ..a. How does Irel a change membrane association of mRNAs? b. Can antioxidants, cyclosporine A, or chemical chaperones improve ire1d''p cell function and change mRNA cellular localization? c...
  9. Novel Antifungal Therapeutic Approaches
    Joseph Heitman; Fiscal Year: 2012
    ..The goal is to harness signaling cascades to develop novel antifungal therapies. ..
  10. Role of Ca2+/Calcineurin Signaling in S. cerevisiae
    Martha S Cyert; Fiscal Year: 2013
    ..Preliminary observations suggest roles for CN and Whi3 in yeast stress granules, which form in response to glucose starvation and contain non-translating mRNAs complexed with initiation factors. ..
  11. Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of Action
    Daniel Shoskes; Fiscal Year: 2013
    ..Therapy with oral Cyclosporine A (CyA) has shown some efficacy in this condition and is a fifth line therapy in the Guidelines of the American ..
  12. Stat5b in Lymphomagenesis: Mechanistic and Therapeutic Implications
    John A Kelly; Fiscal Year: 2012
    ..These experiments have the potential to advance the therapeutic approaches in lymphoma and other malignancies. ..
  13. Hepatic drug metabolism in inflammation
    Romi Ghose; Fiscal Year: 2009
    ..Finally, these studies will provide a basis for screening of individualswith polymorphisms in TLR genes during clinical trials of new drugs. ..
  14. Genotyping and Phenotyping the Hepatitis C Drug Target NS5A
    ROBERT T STRIKER; Fiscal Year: 2011
    ..that have pre- and post-transplant samples to determine if the earliest version of a cyclophilin inhibitor (cyclosporine) that is already in use in transplant patients for purposes other than as an antiviral breeds HCV resistance...
  15. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..
  16. The role of Nox2 in CNI-induced renal fibrosis
    Arjang Djamali; Fiscal Year: 2013
    ..CNIs including cyclosporine A (CsA) and tacrolimus (TAC) are the backbone of anti-rejection therapy in transplantation...
  17. Cyclophilin-CD147 interaction in autoimmune arthritis
    Stephanie L Constant; Fiscal Year: 2010
    ..group of highly abundant cellular proteins mostly known as intracellular receptors for immunosuppressive drug, cyclosporine A, but also exerting extracellular activities...
  18. NFAT and MEF-2 Choreograph Bladder Wall Remodeling Following Partial Outlet Obstr
    STEPHEN ANTHONY ZDERIC; Fiscal Year: 2010
    ..With administration of cyclosporine A (CSA), the resulting bladder hypertrophy is diminished, and there is a reversal of the myosin heavy chain (..
  19. Three-dimensional Human Kidney Tissue System for Studying Renal Diseases
    Jeannine Coburn; Fiscal Year: 2013
    ..Nephrotoxin-induced tubule damage will be investigated using cyclosporine, gentamicin and cisplatin...
  20. Comparative Effectiveness of Biologics for Psoriasis
    Joel M Gelfand; Fiscal Year: 2010
    ..of existing therapies for moderate to severe psoriasis such as phototherapy, acitretin, methotrexate, cyclosporine, alefacept, etanercept, adalimumab, infliximab, and ustekinumab...
  21. Application of Evolutionary Principles to Maintain Cancer Control (PQ21)
    Robert A Gatenby; Fiscal Year: 2013
    ..Finally, we will also study how the addition of estrogen during therapy intervals can be used to increase the fitness of ER+ cells and thus maintain the number of hormonal therapy- sensitive cells. ..
  22. A Structural Approach for Treating Drug Resistant Fungal Pathogens
    Mitchell W Mutz; Fiscal Year: 2013
    ..4. Screen and select compounds against both C. albicans and non-albicans Candida strains. ..
  23. Exploring the Physiology of Leukemic Stem Cells by Mechanisms of Drug Resistance
    Robert W Storms; Fiscal Year: 2010
    ..These studies explore that relationship to help lay the groundwork for therapies that specifically target multiple drug resistance and leukemia stem cells. ..
  24. Cyclophilin D as a Therapeutic Target following Traumatic Brain Injury
    Patrick G Sullivan; Fiscal Year: 2013
    ..Based on the results of these studies, we anticipate that NIM811 will exhibit strong potential as novel therapy for TBI. ..
  25. Training Program in Nephrology Research
    Alfred K Cheung; Fiscal Year: 2011
    ..of chronic renal failure, studying the mechanisms of renal fibrosis in models of diabetic nephropathy, chronic cyclosporine nephropathy, and mesangial proliferative GN;4) renal development, emphasizing relevant transcriptional ..
  26. Calcineurin Phosphatase in Cell Signaling Pathways
    Chi Wing Chow; Fiscal Year: 2010
    ..Defining the role of calcineurin in the 2- adrenergic receptor signaling pathways, therefore, will advance our knowledge of post- transplantation care. ..
  27. Cyclophilins, Cyclophilin Inhibitors and Hepatitis C
    PHILIPPE ANDRE GALLAY; Fiscal Year: 2013
    ..Thus, the development of alternative treatments is essential. The immunosuppressive drug cyclosporine A (CsA) was reported to be clinically effective against HCV infection...
  28. Role of Immune Cells in Immunosuppressive Drug-Induced Hypertension
    Brett M Mitchell; Fiscal Year: 2013
    ..to elucidate the immunological mechanisms by which alterations in T cells caused by the immunosuppressive drugs cyclosporine A (CsA) and FK506 (tacrolimus) alter endothelial function and blood pressure regulation...
  29. Elucidating the role of T-regs in engraftment, GVHD, and DLI immunotherapy
    Christene A Huang; Fiscal Year: 2013
    ..of miniature swine with a low-dose of total body irradiation, partial T-cell depletion, and a short course of cyclosporine A has reliably established donor HC engraftment without GVHD despite infusion of a very high dose of T-cell ..
  30. A new class of immunomodulator, CRAC channel blockers
    Yousang Gwack; Fiscal Year: 2013
    ..Such small molecule blockers targeting Orai1 activity is likely to have much less side effects than immunosuppressive drugs such as cyclosporin A and tacrolimus because the CRAC channel is specifically predominant in immune cells. ..
  31. Functional and structural characterization of spliceosomal cyclophilins
    Tara L Davis; Fiscal Year: 2011
    ..These reagents will be used to elucidate the spliceosome's involvement in disease pathologies. ..
  32. The Importance of Prolyl 3-hydroxylation in recessive Osteogenesis Imperfecta
    ERICA PAIGE HOMAN; Fiscal Year: 2013
    ..abstract_text> ..
  33. Psoriasis treatments, cardiovascular disease, and diabetes
    Lisa J Herrinton; Fiscal Year: 2013
    ..The drugs under study will include anti-TNF agents, methotrexate, oral retinoids and cyclosporine. Risk on these drugs will be compared to risk on phototherapy without systemic agent...
  34. The Role of DEK in the Development of Arthritis
    Nirit Mor Vaknin; Fiscal Year: 2011
    ..These insights are very important to our ability to develop a new strategy to the diagnosis/treatment of JIA, and to improve the present and future health of children with arthritis and related diseases. ..
  35. CELL AND MOLECULAR BIOLOGICAL ANALYSIS OF SYNAPTOPODIN
    PETER H MUNDEL; Fiscal Year: 2013
    ..the podocyte actin cytoskeleton into a migratory phenotype We also established that the calcineurin inhibitor cyclosporine A protects against proteinuria by stabilizing synaptopodin steady-state levels in podocytes...
  36. Pathophysiology of Post-Transplantation Cancer
    Soumitro Pal; Fiscal Year: 2013
    ..Our preliminary studies have shown that the immunosuppressive agent Cyclosporine A (CsA) (known to activate Ras, and to promote tumor growth) can induce CXCL10, and can also markedly ..
  37. Balance of Type 1 and 17 T cell Responses in Airway Rejection: The Role of T-bet
    ELIZABETH ANN LENDERMON; Fiscal Year: 2011
    ..In addition, preliminary data suggests the cyclosporine A, a calcineurin-inhibitor used widely in recipients of solid organ transplant to prevent rejection, inhibits T-..
  38. Functional and structural characterization of spliceosomal cyclophilins
    Tara L Davis; Fiscal Year: 2013
    ..abstract_text> ..
  39. Polyomavirus and Mentoring in Renal Transplantation
    Daniel C Brennan; Fiscal Year: 2012
    ..of polyomavirus (BK) in the urine and blood was the same in patients randomized to receive tacrolimus or cyclosporine. We found that BK appears in the urine before the blood and that levels in the urine are far greater in the ..
  40. Drugging the Undruggable: Targeting Transcription Factors with Small Cyclic Pept
    Joshua A Kritzer; Fiscal Year: 2010
    ..However, potent natural products such as cyclosporine and rapamycin can bind diverse, non-traditional targets that would otherwise be overlooked...
  41. Tracking conformational states in enzyme catalysts using correlated X-ray scatter
    Sebastian Doniach; Fiscal Year: 2013
    ..CypA is the target of the widely used immunosuppressive cyclosporine. The HIV virus has been shown to use human cyclophilin during its final stages of viral replication.
  42. Biosynthesis of Antifungal Lipopeptides from Filamentous Fungi
    Yi Tang; Fiscal Year: 2013
    ....
  43. Complement-mediated injury of the kidney: New mechanisms and novel therapies
    Joshua M Thurman; Fiscal Year: 2013
    ..These experiments will utilize cyclosporine to generate endothelial microparticles and test whether they cause injury in factor H deficient mice...
  44. Molecular mechanism of cellular activation of the hepatitis C virus polymerase
    Julie Akiko Heck; Fiscal Year: 2010
    ..The experiments proposed here would improve our understanding of the mechanism of HCV replication, which in turn should aid the development of more widely effective antiviral drugs. ..
  45. Neuronal specific Autophagy Signaling
    Dale M Ando; Fiscal Year: 2013
    ....
  46. The Role of DEK in the Development of Arthritis
    Nirit Mor-Vaknin; Fiscal Year: 2013
    ..These insights are very important to our ability to develop a new strategy to the diagnosis/treatment of JIA, and to improve the present and future health of children with arthritis and related diseases. ..
  47. The Role of Gut Bacteria in Kupffer Cell Development and Function
    Natasha Corbitt; Fiscal Year: 2013
    ..Alternative strategies preventing liver graft rejection without suppressing the immune system have the potential to change the quality of life of thousands of people. ..
  48. A Phase II Trial of Rituximab In Myasthenia Gravis
    Richard Nowak; Fiscal Year: 2013
    ..therapy with acetylcholinesterase inhibitors and immunotherapy such as corticosteroids, azathioprine, cyclosporine, and plasma exchange (PLEX) and intravenous immunoglobulin (IVIg)...
  49. PRECLINICAL CYCLOSPORIN A THERAPY TRIALS FOR PEDIATRIC TBI
    SUSAN SHEPS MARGULIES; Fiscal Year: 2012
    ..This state-of-the-art, innovative preclinical study design can be applied to future evaluations of other therapies longer treatment windows, other ages, other brain injuries, and to other agents that promote neurorecovery or repair. ..
  50. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2011
    ..situation, a national multicenter NIDDK-funded randomized clinical trial is underway to compare the efficacy of cyclosporine, the current standard of care, with a combination of MMF and oral dexamethasone pulses in patients with steroid-..
  51. Mast cells and immunosuppression in skin cancer
    Traci A Wilgus; Fiscal Year: 2013
    ..Recent studies have demonstrated that cyclosporine A, an immunosuppressive drug commonly taken by transplant patients, alters skin carcinogenesis...
  52. Multicenter Trial of Focal Glomerulosclerosis
    Debbie Gipson; Fiscal Year: 2009
    ..The proposed case-control study will evaluate risk factors for the development of FSGS such as body mass, birth weight, viral illnesses and smoking in all patients screened for entry into the trial. ..
  53. Multi-Mechanism Inhibition of Lipid Peroxidation in TBI
    Edward D Hall; Fiscal Year: 2013
    ..4-hydroxynonenal (4-HNE) scavenger phenelzine or with the mitochondrial permeability transition inhibitor cyclosporine (CsA) can partially attenuate posttraumatic brain LP damage, mitochondrial dysfunction and calpain-mediated ..
  54. A novel bioengineered technique to rapidly and permanently repair cut PNS nerves
    GEORGE DAVIS BITTNER; Fiscal Year: 2013
    ..abstract_text> ..
  55. New Strategies for Modulation of Corneal and Ocular Surface Inflammation
    Reza Dana; Fiscal Year: 2012
    ..Specifically, the following clinical studies are envisioned: 1. Use of topical cyclosporine-A (CsA) for prevention of chronic ocular graft-versus-host disease (GVHD), wherein we hypothesize that ..
  56. Nonmyeloablative Allografting for Immunodeficiency & Other Nonmalignant Disorders
    LAURI M BURROUGHS; Fiscal Year: 2010
    ..or 2 Gy TBI plus fludarabine (n=13) followed by postgrafting immunosuppression with mycophenolate mofetil and cyclosporine. Importantly, markedly decreased TRM was observed compared to conventional regimens, and disease responses were ..
  57. Cyclosporine, Cyclophilins and HCV Replication
    Hengli Tang; Fiscal Year: 2012
    ..In addition, CyPA is a principal mediator of HCV resistance to cyclosporine A (CsA) and its derivatives, which inhibit HCV replication with an undefined mechanism and are currently being ..
  58. Ph 3 of Cyclosporine or Corticosteroids Adjunct to Plasma Exhcange in Tx of TTP
    Haifeng M Wu; Fiscal Year: 2013
    ..initiated a phase III clinical trial with an internal pilot study entitled "A Multi-Center, Randomized Study of Cyclosporine (CSA) or Corticosteroids as an Adjunct to Plasma Exchange (PE) in Initial Therapy of TTP...
  59. Traumatic Brain Injury Clinical Trials Network
    John D Ward; Fiscal Year: 2010
    ..abstract_text> ..
  60. Biochemistry and Biophysics of the Preocular Tear Film
    Igor A Butovich; Fiscal Year: 2013
    ....
  61. Statins for Prevention of GVHD
    MARCO B MIELCAREK; Fiscal Year: 2013
    ..The protective effect was restricted to recipients given cyclosporine (CSP)-based postgrafting immunosuppression and not observed among those given tacrolimus (TAC)...
  62. New Approaches to Axonal Protection After TBI
    Thomas M Reeves; Fiscal Year: 2013
    ..The long-term goal is to translate findings from these laboratory studies to the development of therapeutic strategies to improve white matter functioning specifically, and outcome of TBI generally, in human patients. ..
  63. UROTHELIAL CELL ACTIVATION IN INTERSTITIAL CYSTITIS
    Monica Liebert; Fiscal Year: 1993
    ....
  64. MODULATION OF MULTIDRUG RESISTANCE BY CYCLOSPORIN A
    Charles Erlichman; Fiscal Year: 1992
    ..The proposed studies will evaluate the importance of P-glycoprotein in clinical resistance to MDR and determine whether cyclosporin A can reverse the MDR phenotype in patients...
  65. PHENYTOIN PATHOGENESIS OF GINGIVAL OVERGROWTH
    Thomas Hassell; Fiscal Year: 1990
    ..Four new drugs also have this side effect (cyclosporine-A, nifedipine, valproic acid, felodipine)...
  66. MECHANISM BASED DRUG SELECTION AND DESIGN FOR T GONDII
    Keith Joiner; Fiscal Year: 1999
    ..The administrative core (Joiner) manages the structure necessary for continuing the highly interactive research programs established in the first funding cycle. ..
  67. PATHOGENESIS AND PREVENTION OF IDDM
    Hugh McDevitt; Fiscal Year: 2002
    ..These studies will rely on the same techniques used by Drs. Chien and Davis to trace the development of islet cell specific T cells in the NOD mouse. ..
  68. Sustained release calcineurin inhibitors for the prevention of graft rejection
    Thomas Smith; Fiscal Year: 2007
    ..inhibitors by developing sustained release subcutaneous injectable formulations for the drugs tacrolimus and cyclosporine. Substantial inter-and intra-patient variability means that even frequent drug monitoring cannot eradicate ..
  69. ROLE OF CYCLOSPORINE METABOLISM IN TRANSPLANTATION
    NEIL LEMPERT; Fiscal Year: 1990
    b>Cyclosporine (CsA) is a potent immunosuppressive agent whose widespread usage is severely restricted by its nephrotoxic side effects...
  70. CYCLOPHILIN C FUNCTION
    Jeffrey Friedman; Fiscal Year: 2001
    ..from applicant's abstract) Cyclophilin C (cyp C) is a member of a highly conserved and growing family of cyclosporine A (CsA) binding proteins found in bacteria, unicellular organisms and all plant and animal species tested...