- Characterization of the nodularin synthetase gene cluster and proposed theory of the evolution of cyanobacterial hepatotoxins
Michelle C Moffitt
School of Microbiology and Immunology, The University of New South Wales, Sydney, New South Wales, Australia
Appl Environ Microbiol 70:6353-62. 2004
..In addition, an appreciation of the natural evolution of nonribosomal biosynthetic pathways will be vital for future combinatorial engineering and rational design of novel metabolites and pharmaceuticals...
- Detection and identification of oligopeptides in Microcystis (cyanobacteria) colonies: toward an understanding of metabolic diversity
Technische Universitat Berlin, Institut für Chemie AG Biochemie und Molekulare Biologie, Franklinstr 29, 10587 Berlin, Germany
Peptides 27:2090-103. 2006
..The high number of peptides and especially the new peptides underline the capability of Microcystis strains as producers of a high diversity of potentially bioactive compounds...
- Genetic identification of microcystin ecotypes in toxic cyanobacteria of the genus Planktothrix
Austrian Academy of Sciences, Institute for Limnology, Mondseestrasse 9, A 5310 Mondsee, Austria
Microbiology 151:1525-33. 2005
- Natural variation in the microcystin synthetase operon mcyABC and impact on microcystin production in Microcystis strains
Department of Biology, University of Oslo, Norway
J Bacteriol 185:2774-85. 2003
..Collectively, these results suggest that recombination between imperfect repeats, gene loss, and horizontal gene transfer can explain the distribution and variation within the mcyABC operon...
- Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
Floris A van Gaalen
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 50:2113-21. 2004
..We undertook this study to investigate the relationship between HLA class II gene polymorphisms and RA-specific IgG antibodies against cyclic citrullinated peptides (anti-CCP antibodies)...
- On the antibacterial action of cyclic peptides: insights from coarse-grained MD simulations
UMR Structure et Reactivite des Systemes Moleculaires Complexes, Nancy University, CNRS, France
J Phys Chem B 114:2676-84. 2010
RRKWLWLW] cyclic peptides have been shown to exhibit remarkable in vitro and in vivo antibacterial activity...
- A global assembly line for cyanobactins
Mohamed S Donia
Department of Medicinal Chemistry, University of Utah, 30 South 2000 East, Room 201, Salt Lake City, Utah 84112, USA
Nat Chem Biol 4:341-3. 2008
More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria...
- Impact of alternate definitions of fever resolution on the composite endpoint in clinical trials of empirical antifungal therapy for neutropenic patients with persistent fever: analysis of results from the Caspofungin Empirical Therapy Study
B E de Pauw
University Hospital St Radboud, Nijmegen, The Netherlands
Transpl Infect Dis 8:31-7. 2006
..liposomal amphotericin B as empirical antifungal therapy for febrile neutropenic patients to determine the impact of varying definitions of fever resolution on response rates...
- Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions
Anne Marie Leduc
Department of Chemistry, University of Louisville, Louisville, KY 40292, USA
Proc Natl Acad Sci U S A 100:11273-8. 2003
..The stabilization of minimalist surface motifs may prove useful for the control of other macromolecular assemblies, especially when an amphiphilic helix is crucial for the strong binding interaction between two proteins...
- Environmental applications for biosurfactants
Catherine N Mulligan
Department Building, Civil and Environmental Engineering, Concordia University, 1455 de Maisonneuve Boulevard W, Montreal, Quebec, Canada, H3G 1M8
Environ Pollut 133:183-98. 2005
..As most of the research until now has been performed with rhamnolipids, other biosurfactants need to be investigated as they may have more promising properties...
- [18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates
Department of Nuclear Medicine, Technische Universitat Munchen, 81675 Munchen, Germany
Bioconjug Chem 15:61-9. 2004
..2 GBq of [18F]flouride. Moreover, the fast excretion, the suitable metabolic stability and the low estimated radiation dose allow to evaluate this tracer in human studies...
- Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
Ann Rheum Dis 68:69-74. 2009
- Diversity of microcystin genes within a population of the toxic cyanobacterium Microcystis spp. in Lake Wannsee (Berlin, Germany)
Federal Environmental Agency, Corrensplatz 1, 14195 Berlin, Germany
Microb Ecol 43:107-18. 2002
- Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK
Drug Discovery Department, PharmaMar S A, Tres Cantos, E 28760 Madrid, Spain
J Biol Chem 278:241-50. 2003
..These data provide a molecular basis for the anticancer activity of Aplidin...
- A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly
Robert D Murray
Department of Endocrinology, Leeds Teaching Hospitals National Health Service Trust, Leeds, UK
J Clin Endocrinol Metab 93:2957-68. 2008
..A novel aqueous formulation of lanreotide, lanreotide Autogel (ATG), has recently been approved and is the predominant (and only in the United States) formulation of lanreotide used clinically...
- Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel
M E Williams
SIBIA, Inc, La Jolla, CA 92037
Science 257:389-95. 1992
..The heterogeneity of alpha 1B subunits, along with the heterogeneity of alpha 2 and beta subunits, is consistent with multiple, biophysically distinct N-type calcium channels...
- Bacillus lipopeptides: versatile weapons for plant disease biocontrol
Walloon Centre for Industrial Biology, Agricultural University of Gembloux, Passage des Deportes, 2, B 5030 Gembloux, Belgium
Trends Microbiol 16:115-25. 2008
- The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register
University of Manchester, Manchester, UK
Arthritis Rheum 56:2929-35. 2007
- Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjögren's syndrome
J E Gottenberg
Department of Rheumatology, Bicetre Hospital, INSERM EMI 109, Le Kremlin Bicetre, France
Ann Rheum Dis 64:114-7. 2005
..To investigate the prevalence of anti-cyclic citrullinated peptide (anti-CCP) and anti-keratin antibodies (AKA) in patients with primary Sjögren's syndrome...
- A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, Garching D 85747, Germany
Nature 452:755-8. 2008
..It is thus possible that these bacteria are capable of producing proteasome inhibitors of the syrbactin class...
- Antibody against mutated citrullinated vimentin: a new sensitive marker in the diagnosis of rheumatoid arthritis
Institute for Rheumatology of the Kurstadt Baden RSKA Baden of the NOEGKK and Ludwig Boltzmann Cluster Rheumatology, Balneology and Rehabilitation, Forschungsstelle for Epidemiology of Rheumatic Diseases, 2500 Baden, Austria
Rheumatol Int 29:1315-21. 2009
..In a subgroup of 86 RA patients we found a significant correlation between anti-MCV and disease activity. Anti-MCV appears to be an important marker for the diagnosis of RA, and correlates also with disease activity...
- Antibodies to citrullinated vimentin are a specific and sensitive marker for the diagnosis of rheumatoid arthritis
Division of Immunology, Hammersmith Hospitals NHS Trust, and Kennedy Institute of Rheumatology, Imperial College, London, UK
Clin Rev Allergy Immunol 34:4-10. 2008
..Antibodies to citrullinated vimentin were first described in 1994 as a highly specific marker for RA (anti-Sa). However, no easily performed assay for these antibodies has been available...
- Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels
Physiopathologie des Canaux Ioniques, Institut de Genetique Humaine, CNRS UPR1142, 34396 Montpellier Cedex 5, France
Biophys J 81:79-88. 2001
..We conclude that SNX482 does not exhibit unequivocal specificity for R-type channels, but highly effectively antagonizes their activation...
- Clinical utility of the anti-CCP assay in patients with rheumatic diseases
D M Lee
Department of Medicine, Division of Rheumatology, Immunology and Allergy Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Ann Rheum Dis 62:870-4. 2003
..To determine the frequency of antibodies to cyclic citrullinated peptides (CCP) in a group of patients with a diversity of rheumatic diseases...
- Autoantibody profile in rheumatoid arthritis during long-term infliximab treatment
Department of Rheumatology University of Pavia, IRCCS Policlinico S, Matteo, Pavia, Italy
Arthritis Res Ther 6:R264-72. 2004
..Also, the evolution of RF titres and that of anti-CCP antibody titres differed during long-term infliximab therapy...
- Biocontrol of Bacillus subtilis against infection of Arabidopsis roots by Pseudomonas syringae is facilitated by biofilm formation and surfactin production
Harsh Pal Bais
Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, Colorado 80523 1173, USA
Plant Physiol 134:307-19. 2004
..syringae. Our results collectively indicate that upon root colonization, B. subtilis 6051 forms a stable, extensive biofilm and secretes surfactin, which act together to protect plants against attack by pathogenic bacteria...
- Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis
Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
Rheumatology (Oxford) 42:677-80. 2003
- Caspofungin: the first representative of a new antifungal class
Institut de Parasitologie et de Pathologie Tropicale, Faculte de Medecine, 3 Rue Koeberle, 67000 Strasbourg, France
J Antimicrob Chemother 51:513-21. 2003
..Further studies are required to define the exact role of caspofungin in the antifungal armamentarium...
Stanley C Deresinski
Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA, 95128, USA
Clin Infect Dis 36:1445-57. 2003
..Caspofungin is an important addition to the antifungal pharmacopoeia...
- Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 187:1834-43. 2003
..The combination of an antifungal triazole and echinocandin may represent a new strategy for treatment of invasive pulmonary aspergillosis...
- The iturin and fengycin families of lipopeptides are key factors in antagonism of Bacillus subtilis toward Podosphaera fusca
Departamento de Microbiologia, Facultad de Ciencias, Universidad de Malaga, Campus Universitario de Teatinos s n, E 29071 Malaga, Spain
Mol Plant Microbe Interact 20:430-40. 2007
..Taken together, our data have allowed us to conclude that the iturin and fengycin families of lipopeptides have a major role in the antagonism of B. subtilis toward P. fusca...
- Partial surgical removal of growth hormone-secreting pituitary tumors enhances the response to somatostatin analogs in acromegaly
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
J Clin Endocrinol Metab 91:85-92. 2006
..Surgery is a cornerstone in the treatment of acromegaly, but its efficacy in large, invasive tumors is scant...
- Cyanobactins-ribosomal cyclic peptides produced by cyanobacteria
Department of Food and Environmental Sciences, Division of Microbiology, Viikki Biocenter, University of Helsinki, Helsinki, P O Box 56, Viikinkaari 9, FIN 00014, Finland
Appl Microbiol Biotechnol 86:1213-25. 2010
Cyanobactins are small cyclic peptides that are produced by a diverse selection of cyanobacteria living in symbioses as well as terrestrial, marine, or freshwater environments...
- Expression of the nodularin synthetase genes in the Baltic Sea bloom-former cyanobacterium Nodularia spumigena strain AV1
Department of Botany, Stockholm University, Stockholm, Sweden
FEMS Microbiol Ecol 65:31-9. 2008
..In contrast to the shifts in expression, the intracellular and extracellular nodularin concentrations did not vary significantly during the treatments...
- Cytotoxic and peptidase inhibitory activities of selected non-hepatotoxic cyclic peptides from cyanobacteria
Department of Genetic Toxicology, National Institute of Biology, Vecna pot 111, POB 141, SI 1001 Ljubljana, Slovenia
Biol Chem 389:1339-46. 2008
..Two main groups of cyclic peptides, depsipeptides and ureido linkage-containing peptides, reportedly inhibit serine peptidases...
- Anti-citrullinated protein/peptide antibodies (ACPA) in rheumatoid arthritis: specificity and relation with rheumatoid factor
B Vander Cruyssen
Department of Rheumatology, Ghent University Hospital, B 9000 Gent, Belgium
Autoimmun Rev 4:468-74. 2005
..Indeed, both antibody systems have a different association with specific RA features like extra-articular manifestations, a different association with the HLA shared epitope and, behave differently following anti-TNF therapy...
- Combinations of antifungal agents in therapy--what value are they?
Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Madrid, Spain
J Antimicrob Chemother 54:854-69. 2004
..However, combination therapy could be an alternative to monotherapy for patients with invasive infections that are difficult to treat, such as those due to multi-resistant species and for those who fail to respond to standard treatment...
- Treatment with caspofungin in immunocompromised paediatric patients: a multicentre survey
Andreas H Groll
Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Paediatric Haematology Oncology, Children s University Hospital, Muenster, Germany
J Antimicrob Chemother 57:527-35. 2006
..We conducted a multicentre retrospective survey to obtain data on immunocompromised paediatric patients considered to require caspofungin therapy...
- Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status
So Young Bang
Hospital for Rheumatic Diseases, Hanyang University, Seoul, South Korea
Arthritis Rheum 62:369-77. 2010
- Design of cyclic peptides that bind protein surfaces with antibody-like affinity
Steven W Millward
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
ACS Chem Biol 2:625-34. 2007
..Using this library, we have designed a number of high-affinity, redox-insensitive, cyclic peptides that target the signaling protein G alpha i1...
- Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles
S P Linn-Rasker
Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, Netherlands
Ann Rheum Dis 65:366-71. 2006
..To study the gene-environment interaction of tobacco exposure and shared epitope on autoantibodies in patients with rheumatoid arthritis and undifferentiated arthritis...
- Evaluation of a (99m)Tc-labeled cyclic RGD tetramer for noninvasive imaging integrin alpha(v)beta3-positive breast cancer
School of Health Sciences, Purdue University, West Lafayette, Indiana 47907 2051, USA
Bioconjug Chem 18:438-46. 2007
..i. The high tumor uptake and fast renal excretion make [99mTc(HYNIC-tetramer)(tricine)(TPPTS)] a promising radiotracer for noninvasive imaging of the integrin alphavbeta3-positive tumors by SPECT...
- Formation of diagnostic product ions from cyanobacterial cyclic peptides by the two-bond fission mechanism using ion trap liquid chromatography/multi-stage mass spectrometry
Graduate School of Environmental and Human Science, Meijo University, Tempaku, Nagoya 468 8503, Japan
Rapid Commun Mass Spectrom 21:1025-33. 2007
..However, in the case of cyclic peptides, the fragmentation pattern is complicated because the cleavages occur randomly and product ions are generated ..
- Marine bacteria associated with sponge as source of cyclic peptides
Salvatore De Rosa
Istituto di Chimica Biomolecole CNR, Via Campi Flegrei, 34, I 80078 Pozzuoli, Naples, Italy
Biomol Eng 20:311-6. 2003
..Several diketopiperazines were isolated from both bacteria and the hypothesis of their role in the bacterial-spongy interaction is discussed...
- Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula
Istituto di Chimica Biomolecole CNR, Via Campi Flegrei 34, I 80078 Pozzuoli, Naples, Italy
J Nat Prod 67:1178-81. 2004
Two new cyclic peptides, cyclo-(glycyl-L-seryl-L-prolyl-L-glutamyl) and cyclo-(glycyl-L-prolyl-L-glutamyl), have been isolated from the cell extract of a Ruegeria strain associated with cell cultures of Suberites domuncula...
- Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides
Department of Chemistry and Biochemistry, University of California at Santa Cruz, Santa Cruz, CA 95064, USA
J Am Chem Soc 128:14073-80. 2006
We report an atomistic physical model for the passive membrane permeability of cyclic peptides. The computational modeling was performed in advance of the experiments and did not involve the use of "training data"...
- MicroPET imaging of brain tumor angiogenesis with 18F-labeled PEGylated RGD peptide
PET Imaging Science Center, Department of Radiology, University of Southern California Keck School of Medicine, 1510 San Pablo St, Suite 350, CA 90033, Los Angeles, USA
Eur J Nucl Med Mol Imaging 31:1081-9. 2004
..In conclusion, PEGylation suitably modifies the physiological behavior of the RGD peptide. [18F]FB-PEG-RGD gave improved tumor retention and in vivo kinetics compared with [18F]FB-RGD...
- Micro-PET imaging of alphavbeta3-integrin expression with 18F-labeled dimeric RGD peptide
University of Southern California, Los Angeles, USA
Mol Imaging 3:96-104. 2004
..5 +/- 0.8. The synergistic effect of polyvalency and improved pharmacokinetics may be responsible for the superior imaging characteristics of [18F]FB-E[c(RGDyK)]2...
- Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis
Department of Medicine, Division of Rheumatology, University of Sherbrooke, Sherbrooke, Quebec, Canada
Arthritis Res Ther 7:R592-603. 2005
- Diagnostic performances of anti-cyclic citrullinated peptides antibody and antifilaggrin antibody in Korean patients with rheumatoid arthritis
Suk Woo Choi
Department of Laboratory Medicine, Eulji University, School of Medicine, Daejeon, Korea
J Korean Med Sci 20:473-8. 2005
- Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti-cyclic citrullinated peptide antibody
T R Mikuls
Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Arthritis Rheum 50:3776-82. 2004
..To examine the association of treatment response and disease duration with changes in rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody levels among patients with rheumatoid arthritis (RA)...
- Anti-cyclic citrullinated peptide antibody in rheumatoid arthritis: relation with disease aggressiveness
N del Val del Amo
Rheumatology Department, Navarra Hospital, Pamplona, Spain
Clin Exp Rheumatol 24:281-6. 2006
..To analyse the value of the anti-cyclic citrullinated peptide antibody (anti-CCP) in patients with rheumatoid arthritis (RA) as a prognostic factor, as well as its relationship with disease activity...
- Systemic antibacterial activity of novel synthetic cyclic peptides
Novartis Institute for Tropical Diseases, 10 Biopolis Rd, 05 01 Chromos, Singapore 138670
Antimicrob Agents Chemother 49:3302-10. 2005
b>Cyclic peptides with an even number of alternating d,l-alpha-amino acid residues are known to self-assemble into organic nanotubes...
- Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study
W H Bos
Jan van Breemen Instituut, Amsterdam, The Netherlands
Ann Rheum Dis 69:490-4. 2010
..Anti-citrullinated protein antibodies (ACPA) are associated with increased risk for rheumatoid arthritis...
- Imaging of delayed-type hypersensitivity reaction by PET and 18F-galacto-RGD
Bernd J Pichler
Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
J Nucl Med 46:184-9. 2005
Radiolabeled cyclic peptides containing the amino acid sequence arginine-glycine-aspartate (RGD peptides) have successfully been used to image the expression of the alpha(v)beta(3) integrin in malignant tumors...
- Rheumatoid factor and antibodies to cyclic citrullinated Peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis
Annemarie L M A Jansen
Jan van Breemen Instituut and the Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands
J Rheumatol 29:2074-6. 2002
- Optimalization and cost management of lanreotide-Autogel therapy in acromegaly
Department of Endocrinology, University Hospital of Antwerp, Wilrijkstraat 1, B 2650 Antwerp, Belgium
Eur J Endocrinol 157:571-7. 2007
..Lanreotide-Autogel is a depot formulation of the somatostatin analog lanreotide used in the treatment of acromegaly. We investigated whether prolonging or shortening the interval between injections would offer any benefit...
- Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation
Institut fur Organische Chemie und Biochemie, Technische Universität Munich, Lichtenbergstrasse 4, 85747 Garching, Germany
Chemistry 9:2717-25. 2003
..The conjugates were obtained in good yield without the need of a protection strategy and under mild conditions...
- Role of lipopeptides produced by Bacillus subtilis GA1 in the reduction of grey mould disease caused by Botrytis cinerea on apple
Service de Technologie Microbienne, CWBI, Universite de Liege, Liege, Belgium
J Appl Microbiol 96:1151-60. 2004
..Test of Bacillus subtilis strain GA1 for its potential to control grey mould disease of apple caused by Botrytis cinerea...
- Argyrins, immunosuppressive cyclic peptides from myxobacteria. II. Structure elucidation and stereochemistry
GBF, Gesellschaft fur Biotechnologische Forschung mbH, Abteilung Naturstoffchemie, Braunschweig, Germany
J Antibiot (Tokyo) 55:715-21. 2002
..Argyrins A and B are identical with the antibiotics A21459 A and B, whose structures are revised with respect to 4'-methoxytryptophan...
- Combination treatment with Grb7 peptide and Doxorubicin or Trastuzumab (Herceptin) results in cooperative cell growth inhibition in breast cancer cells
S C Pero
Department of Surgery, Vermont Cancer Comprehensive Center, College of Medicine, University of Vermont, Burlington, VT 05405, USA
Br J Cancer 96:1520-5. 2007
..This Grb7 peptide has potential to be developed as a therapeutic agent alone, in combination with traditional chemotherapy, or in combination with other targeting molecules...
- Largamides A-H, unusual cyclic peptides from the marine cyanobacterium Oscillatoria sp
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0820, USA
J Org Chem 71:6898-907. 2006
..Largamides D-G (4-7) inhibited chymotrypsin with IC(50) values ranging between 4 and 25 microM...
- Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population
Ann W Morgan
Leeds Musculoskeletal Biomedical Research Unit, Institute of Molecular Medicine, University of Leeds, St James University Hospital, Leeds, UK
Arthritis Rheum 60:2565-76. 2009
..To define interactions between the HLA-DRB1 shared epitope (SE), PTPN22, and smoking in cyclic citrullinated peptide (CCP) antibody- and rheumatoid factor (RF)-positive and -negative rheumatoid arthritis (RA)...
- In vitro activity of caspofungin against Candida albicans biofilms
Stefano P Bachmann
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
Antimicrob Agents Chemother 46:3591-6. 2002
..albicans. Together these findings indicate that caspofungin displays potent activity against C. albicans biofilms in vitro and merits further investigation for the treatment of biofilm-associated infections...
- Efficacy of caspofungin alone and in combination with voriconazole in a Guinea pig model of invasive aspergillosis
William R Kirkpatrick
Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
Antimicrob Agents Chemother 46:2564-8. 2002
..The combinations of CAS plus VRC were highly effective in this model and should be further evaluated for use against invasive aspergillosis...
- The immunopathogenesis of rheumatoid arthritis
John B Imboden
Department of Medicine, University of California, and Division of Rheumatology, San Francisco General Hospital, San Francisco, CA 94110, USA
Annu Rev Pathol 4:417-34. 2009
..There is a strong association between shared-epitope-expressing HLA-DRB1 alleles and the development of rheumatoid arthritis associated with autoimmunity to citrullinated protein antigens...
- Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis
Uppsala University, Uppsala, Sweden
Arthritis Rheum 56:2202-10. 2007
..To determine whether genetic variants of the interferon regulatory factor 5 (IRF-5) and Tyk-2 genes are associated with rheumatoid arthritis (RA)...
- Halogenated cyclic peptides isolated from the sponge Corticium sp
Damian W Laird
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
J Nat Prod 70:741-6. 2007
..led to the isolation of the known active alkaloid steroid plakinamine A and two new halogenated cyclic peptides, corticiamide A (1) and cyclocinamide B (2)...
- Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans
Teresa T Liu
Department of Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, and Le Bonheur Children s Medical Center, Room 304 West Patient Tower, Children s Foundation Research Center, 50 North Dunlap Street, Memphis, TN 38163, USA
Antimicrob Agents Chemother 49:2226-36. 2005
..Genes responding similarly to two or more drugs were also identified. These data shed new light on the effects of these classes of antifungal agents on C. albicans...
- Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia
Thomas J Walsh
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
N Engl J Med 351:1391-402. 2004
..Caspofungin, a member of the new echinocandin class of compounds, may be an effective alternative that is better tolerated than amphotericin B...
- Cyclic peptides from an endophytic fungus obtained from a mangrove leaf (Kandelia candel)
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People s Republic of China
J Nat Prod 70:1696-9. 2007
..Both of these new cyclo-depsipeptides were found to contain one d-amino acid. In the MTT bioassay, 1962A (1) showed weak activity against human breast cancer MCF-7 cells...
- Comparison of caspofungin and amphotericin B for invasive candidiasis
Neeman ICIC and Hospital Mexico, C C S S, San Jose, Costa Rica
N Engl J Med 347:2020-9. 2002
..Caspofungin is an echinocandin agent with fungicidal activity against candida species. We performed a double-blind trial to compare caspofungin with amphotericin B deoxycholate for the primary treatment of invasive candidiasis...
- Nodularin uptake by seafood during a cyanobacterial bloom
P G Van Buynder
Victorian Department of Human Services, GPO Box 1670N, Melbourne, VIC 3001
Environ Toxicol 16:468-71. 2001
..Nodularin concentrations in the flesh of finfish remained low. Boiling the seafood redistributed toxin between viscera and flesh. The results were used to restrict some seafood harvesting...
- Determination of oligopeptide diversity within a natural population of Microcystis spp. (cyanobacteria) by typing single colonies by matrix-assisted laser desorption ionization-time of flight mass spectrometry
Biotechnology Center and Max Vollmer Institute, Technical University Berlin, 10587 Berlin, Germany
Appl Environ Microbiol 67:5069-76. 2001
..It could be demonstrated that the typing of single colonies by MALDI-TOF MS may be a valuable tool for ecological studies of the genus Microcystis as well as in early warning of toxic cyanobacterial blooms...
- Pharmacokinetics and population pharmacodynamic analysis of lanreotide Autogel
Joseph M Cendros
Pharmacokinetics and Metabolism Service, Ipsen Pharma S A, 08980 Saint Feliu Llobregat, Barcelona, Spain
Metabolism 54:1276-81. 2005
..206 ng/mL, showing a high sensitivity to lanreotide, with a predictably high interpatient variability of 200.75% reflecting the range of dosing regimens needed to control GH...
- Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis
Department of Hepato Biliary Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
J Natl Cancer Inst 98:491-8. 2006
..In this study, we evaluated Grb7 protein as a molecular target of therapy for metastatic pancreatic cancer...
- Widespread occurrence and lateral transfer of the cyanobactin biosynthesis gene cluster in cyanobacteria
Department of Applied Chemistry and Microbiology, University of Helsinki, Viikki Biocenter, Helsinki, Finland
Appl Environ Microbiol 75:853-7. 2009
Cyanobactins are small cyclic peptides produced by cyanobacteria. Here we demonstrate the widespread but sporadic occurrence of the cyanobactin biosynthetic pathway...
- Echinocandin antifungal drugs
David W Denning
Education and Research Centre, Wythenshawe Hospital, Southmoor Road, M23 9LT, Manchester, UK
Lancet 362:1142-51. 2003
..Absence of antagonism in combination with other antifungal drugs suggests that combination antifungal therapy could become a general feature of the echinocandins, particularly for invasive aspergillosis...
- Long-term (up to 18 years) effects on GH/IGF-1 hypersecretion and tumour size of primary somatostatin analogue (SSTa) therapy in patients with GH-secreting pituitary adenoma responsive to SSTa
Jean Christophe Maiza
Department of Endocrinology, CHU Rangueil, 31059 Toulouse, France
Clin Endocrinol (Oxf) 67:282-9. 2007
..The role of somatostatin analogues (SSTa) in the treatment of acromegaly...
- Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors
Matthew S Kelker
Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02903, USA
J Mol Biol 385:11-21. 2009
..Furthermore, since tautomycin is a linear non-peptide-based toxin, our reported structure will aid the design of lead compounds for novel PP1-specific pharmaceuticals...
- Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP)
Section of Rheumatology, Helsingborgs Iasarett, Helsingborg, Sweden
Ann Rheum Dis 63:1090-5. 2004
..To investigate the role of anti-cyclic citrullinated peptide antibody (anti-CCP) for the prediction of radiological outcome in patients with early rheumatoid arthritis...
- Cyclic coordinate descent: A robotics algorithm for protein loop closure
Adrian A Canutescu
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Protein Sci 12:963-72. 2003
..It succeeds in closing loops in a large test set 99.79% of the time, and fails occasionally only for short, highly extended loops. It is very fast, closing loops of length 8 in 0.037 sec on average...
- Highly diverse cyanobactins in strains of the genus Anabaena
Lehrbereich Mikrobielle Genetik, Eberhard Karls Universitat Tubingen, 72076 Tubingen, Germany
Appl Environ Microbiol 76:701-9. 2010
Cyanobactins are small, cyclic peptides recently found in cyanobacteria...
- Neopetrosiamides, peptides from the marine sponge Neopetrosia sp. that inhibit amoeboid invasion by human tumor cells
David E Williams
Department of Chemistry, Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1
Org Lett 7:4173-6. 2005
..collected in Papua New Guinea. The structures of the neopetrosiamides were elucidated by analysis of MS and NMR data and confirmed by chemical degradation...
- Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor
Molecular Angiogenesis Laboratory, INSERM E 0113, Universite de Bordeaux 1, 33405 Talence, France
J Biol Chem 278:35564-73. 2003
..Taken together, these results suggest that cyclo-VEGI is an attractive candidate for the development of novel angiogenesis inhibitor molecules useful for the treatment of cancer and other angiogenesis-related diseases...
- Exploring the conformational space of cyclic peptides by a stochastic search method
Department of Medicinal Chemistry and Natural Products, David R Bloom Center for Pharmacy, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
J Mol Graph Model 22:319-33. 2004
A stochastic search algorithm is applied in order to probe the conformations of cyclic peptides. The search is conducted in two stages...
- Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides
Jan H van Maarseveen
Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Org Lett 7:4503-6. 2005
- Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/dopaminergic chimeric ligand
Song Guang Ren
Cedars Sinai Research Institute, University of California School of Medicine, Los Angeles, California 90048, USA
J Clin Endocrinol Metab 88:5414-21. 2003
..The SRIF/DA chimeric molecule, BIM-23A387, represents a novel tool for effective drug treatment of acromegaly and for prolactinomas otherwise resistant to dopaminergic therapy...
- Functional haplotypes of PADI4: relevance for rheumatoid arthritis specific synovial intracellular citrullinated proteins and anticitrullinated protein antibodies
Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
Ann Rheum Dis 64:1316-20. 2005
..Haplotypes of PADI4, encoding for a citrullinating enzyme, were associated with rheumatoid arthritis in a Japanese population. It was suggested they were related to the presence of anticitrullinated protein antibodies (ACPA)...
- The microcystin composition of the cyanobacterium Planktothrix agardhii changes toward a more toxic variant with increasing light intensity
Aquatic Microbiology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Nieuwe Achtergracht 127, 1018 WS Amsterdam, The Netherlands
Appl Environ Microbiol 71:5177-81. 2005
..Since microcystin-DeLR is considerably more toxic than microcystin-DeRR, this implies that P. agardhii becomes more toxic at high light intensities...
- Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
J Am Chem Soc 123:5418-23. 2001
..Apratoxin A (1) possesses IC(50) values for in vitro cytotoxicity against human tumor cell lines ranging from 0.36 to 0.52 nM; however, it was only marginally active in vivo against a colon tumor and ineffective against a mammary tumor...
- "Non-toxic" cyclic peptides induce lysis of cyanobacteria-an effective cell population density control mechanism in cyanobacterial blooms
Department of Genetic Toxicology and Cancer Biology, National Institute of Biology Ljubljana, Vecna pot 111, 1000, Ljubljana, Slovenia
Microb Ecol 56:201-9. 2008
..aeruginosa cell line without lytic effects. Nevertheless, the presence of "non-toxic" cyclic peptides of cyanobacterial origin can induce lysis of these previously infected cells...
- Probing diameter-selective solubilisation of carbon nanotubes by reversible cyclic peptides using molecular dynamics simulations
S R Friling
Dept of Chemistry and Centre for Scientific Computing, University of Warwick, Coventry, U K
Nanoscale 2:98-106. 2010
Molecular dynamics simulations are used to explore the encapsulation behaviour of reversible cyclic peptides when adsorbed onto single-walled carbon nanotubes (CNTs) in aqueous solution...
- Molecular cloning, pharmacological characterization, and brain mapping of the melanocortin 4 receptor in the goldfish: involvement in the control of food intake
Jose Miguel Cerdá-Reverter
Department of Biological Sciences, University of Alberta, Edmonton, Alberta, T6G 2E9 Canada
Endocrinology 144:2336-49. 2003
- Association of anti-cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis
Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
Arthritis Rheum 56:1454-63. 2007
..This study was undertaken to determine whether anti-CCP levels are associated with PADI4 haplotypes and/or SE alleles in Korean patients with RA...
- Localization studies of ioactive cyclic peptides in the ascidian Lissoclinum patella
Christine E Salomon
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0212, USA
J Nat Prod 65:689-92. 2002
A Palauan specimen of the ascidian Lissoclinum patella contained the cyclic peptides patellamides A-C. In contrast to previous reports concerning the location of cyclic peptides in L. patella and L...
- Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models
Joshua A Kritzer
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
Nat Chem Biol 5:655-63. 2009
Phage display has demonstrated the utility of cyclic peptides as general protein ligands but cannot access proteins inside eukaryotic cells...
- Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis
Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium
Cancer 107:2888-97. 2006
..Interest remains as to whether caspofungin, in combination with other antifungal classes, can improve the efficacy against IA...
- Cyclic peptides from Oldenlandia affinis DC. Molecular and biological properties
Department of Biochemistry Biotechnology Center of Oslo, University of Oslo, N 0316 Oslo
Chem Biodivers 5:2014-22. 2008
..All three peptides showed hemolytic activity on human blood, and were tested for antibiotic effect against E. coli, Staphylococcus aureus, and Hemophilus influenzae...
- NMR analysis of G7-18NATE, a nonphosphorylated cyclic peptide inhibitor of the Grb7 adapter protein
C J Porter
School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Perth, WA, Australia
Biopolymers 88:174-81. 2007
..This suggests that there is scope for increasing the rigidity of the peptide that may enhance its binding affinity and specificity for Grb7...
- Modified low molecular weight cyclic peptides as mimetics of BDNF with improved potency, proteolytic stability and transmembrane passage in vitro
Jordan M Fletcher
The Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia
Bioorg Med Chem 17:2695-702. 2009
..Select members of this second generation of compounds showed improved biological activity, stability in plasma, and an ability to cross model biological membranes...