cyclic peptides


Top Publications

  1. pmc Characterization of the nodularin synthetase gene cluster and proposed theory of the evolution of cyanobacterial hepatotoxins
    Michelle C Moffitt
    School of Microbiology and Immunology, The University of New South Wales, Sydney, New South Wales, Australia
    Appl Environ Microbiol 70:6353-62. 2004
  2. ncbi Detection and identification of oligopeptides in Microcystis (cyanobacteria) colonies: toward an understanding of metabolic diversity
    Martin Welker
    Technische Universitat Berlin, Institut für Chemie AG Biochemie und Molekulare Biologie, Franklinstr 29, 10587 Berlin, Germany
    Peptides 27:2090-103. 2006
  3. ncbi Genetic identification of microcystin ecotypes in toxic cyanobacteria of the genus Planktothrix
    Rainer Kurmayer
    Austrian Academy of Sciences, Institute for Limnology, Mondseestrasse 9, A 5310 Mondsee, Austria
    Microbiology 151:1525-33. 2005
  4. pmc Natural variation in the microcystin synthetase operon mcyABC and impact on microcystin production in Microcystis strains
    Bjørg Mikalsen
    Department of Biology, University of Oslo, Norway
    J Bacteriol 185:2774-85. 2003
  5. ncbi Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
    Floris A van Gaalen
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:2113-21. 2004
  6. ncbi On the antibacterial action of cyclic peptides: insights from coarse-grained MD simulations
    Adil Khalfa
    UMR Structure et Reactivite des Systemes Moleculaires Complexes, Nancy University, CNRS, France
    J Phys Chem B 114:2676-84. 2010
  7. pmc A global assembly line for cyanobactins
    Mohamed S Donia
    Department of Medicinal Chemistry, University of Utah, 30 South 2000 East, Room 201, Salt Lake City, Utah 84112, USA
    Nat Chem Biol 4:341-3. 2008
  8. ncbi Impact of alternate definitions of fever resolution on the composite endpoint in clinical trials of empirical antifungal therapy for neutropenic patients with persistent fever: analysis of results from the Caspofungin Empirical Therapy Study
    B E de Pauw
    University Hospital St Radboud, Nijmegen, The Netherlands
    Transpl Infect Dis 8:31-7. 2006
  9. pmc Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions
    Anne Marie Leduc
    Department of Chemistry, University of Louisville, Louisville, KY 40292, USA
    Proc Natl Acad Sci U S A 100:11273-8. 2003
  10. ncbi Environmental applications for biosurfactants
    Catherine N Mulligan
    Department Building, Civil and Environmental Engineering, Concordia University, 1455 de Maisonneuve Boulevard W, Montreal, Quebec, Canada, H3G 1M8
    Environ Pollut 133:183-98. 2005

Detail Information

Publications312 found, 100 shown here

  1. pmc Characterization of the nodularin synthetase gene cluster and proposed theory of the evolution of cyanobacterial hepatotoxins
    Michelle C Moffitt
    School of Microbiology and Immunology, The University of New South Wales, Sydney, New South Wales, Australia
    Appl Environ Microbiol 70:6353-62. 2004
    ..In addition, an appreciation of the natural evolution of nonribosomal biosynthetic pathways will be vital for future combinatorial engineering and rational design of novel metabolites and pharmaceuticals...
  2. ncbi Detection and identification of oligopeptides in Microcystis (cyanobacteria) colonies: toward an understanding of metabolic diversity
    Martin Welker
    Technische Universitat Berlin, Institut für Chemie AG Biochemie und Molekulare Biologie, Franklinstr 29, 10587 Berlin, Germany
    Peptides 27:2090-103. 2006
    ..The high number of peptides and especially the new peptides underline the capability of Microcystis strains as producers of a high diversity of potentially bioactive compounds...
  3. ncbi Genetic identification of microcystin ecotypes in toxic cyanobacteria of the genus Planktothrix
    Rainer Kurmayer
    Austrian Academy of Sciences, Institute for Limnology, Mondseestrasse 9, A 5310 Mondsee, Austria
    Microbiology 151:1525-33. 2005
  4. pmc Natural variation in the microcystin synthetase operon mcyABC and impact on microcystin production in Microcystis strains
    Bjørg Mikalsen
    Department of Biology, University of Oslo, Norway
    J Bacteriol 185:2774-85. 2003
    ..Collectively, these results suggest that recombination between imperfect repeats, gene loss, and horizontal gene transfer can explain the distribution and variation within the mcyABC operon...
  5. ncbi Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
    Floris A van Gaalen
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 50:2113-21. 2004
    ..We undertook this study to investigate the relationship between HLA class II gene polymorphisms and RA-specific IgG antibodies against cyclic citrullinated peptides (anti-CCP antibodies)...
  6. ncbi On the antibacterial action of cyclic peptides: insights from coarse-grained MD simulations
    Adil Khalfa
    UMR Structure et Reactivite des Systemes Moleculaires Complexes, Nancy University, CNRS, France
    J Phys Chem B 114:2676-84. 2010
    RRKWLWLW] cyclic peptides have been shown to exhibit remarkable in vitro and in vivo antibacterial activity...
  7. pmc A global assembly line for cyanobactins
    Mohamed S Donia
    Department of Medicinal Chemistry, University of Utah, 30 South 2000 East, Room 201, Salt Lake City, Utah 84112, USA
    Nat Chem Biol 4:341-3. 2008
    More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria...
  8. ncbi Impact of alternate definitions of fever resolution on the composite endpoint in clinical trials of empirical antifungal therapy for neutropenic patients with persistent fever: analysis of results from the Caspofungin Empirical Therapy Study
    B E de Pauw
    University Hospital St Radboud, Nijmegen, The Netherlands
    Transpl Infect Dis 8:31-7. 2006
    ..liposomal amphotericin B as empirical antifungal therapy for febrile neutropenic patients to determine the impact of varying definitions of fever resolution on response rates...
  9. pmc Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions
    Anne Marie Leduc
    Department of Chemistry, University of Louisville, Louisville, KY 40292, USA
    Proc Natl Acad Sci U S A 100:11273-8. 2003
    ..The stabilization of minimalist surface motifs may prove useful for the control of other macromolecular assemblies, especially when an amphiphilic helix is crucial for the strong binding interaction between two proteins...
  10. ncbi Environmental applications for biosurfactants
    Catherine N Mulligan
    Department Building, Civil and Environmental Engineering, Concordia University, 1455 de Maisonneuve Boulevard W, Montreal, Quebec, Canada, H3G 1M8
    Environ Pollut 133:183-98. 2005
    ..As most of the research until now has been performed with rhamnolipids, other biosurfactants need to be investigated as they may have more promising properties...
  11. ncbi [18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates
    Roland Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, 81675 Munchen, Germany
    Bioconjug Chem 15:61-9. 2004
    ..2 GBq of [18F]flouride. Moreover, the fast excretion, the suitable metabolic stability and the low estimated radiation dose allow to evaluate this tracer in human studies...
  12. pmc Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
    C Potter
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Ann Rheum Dis 68:69-74. 2009
  13. ncbi Diversity of microcystin genes within a population of the toxic cyanobacterium Microcystis spp. in Lake Wannsee (Berlin, Germany)
    Rainer Kurmayer
    Federal Environmental Agency, Corrensplatz 1, 14195 Berlin, Germany
    Microb Ecol 43:107-18. 2002
  14. ncbi Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK
    Ana Cuadrado
    Drug Discovery Department, PharmaMar S A, Tres Cantos, E 28760 Madrid, Spain
    J Biol Chem 278:241-50. 2003
    ..These data provide a molecular basis for the anticancer activity of Aplidin...
  15. ncbi A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly
    Robert D Murray
    Department of Endocrinology, Leeds Teaching Hospitals National Health Service Trust, Leeds, UK
    J Clin Endocrinol Metab 93:2957-68. 2008
    ..A novel aqueous formulation of lanreotide, lanreotide Autogel (ATG), has recently been approved and is the predominant (and only in the United States) formulation of lanreotide used clinically...
  16. ncbi Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel
    M E Williams
    SIBIA, Inc, La Jolla, CA 92037
    Science 257:389-95. 1992
    ..The heterogeneity of alpha 1B subunits, along with the heterogeneity of alpha 2 and beta subunits, is consistent with multiple, biophysically distinct N-type calcium channels...
  17. ncbi Bacillus lipopeptides: versatile weapons for plant disease biocontrol
    Marc Ongena
    Walloon Centre for Industrial Biology, Agricultural University of Gembloux, Passage des Deportes, 2, B 5030 Gembloux, Belgium
    Trends Microbiol 16:115-25. 2008
  18. pmc The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register
    M Bukhari
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:2929-35. 2007
  19. pmc Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjögren's syndrome
    J E Gottenberg
    Department of Rheumatology, Bicetre Hospital, INSERM EMI 109, Le Kremlin Bicetre, France
    Ann Rheum Dis 64:114-7. 2005
    ..To investigate the prevalence of anti-cyclic citrullinated peptide (anti-CCP) and anti-keratin antibodies (AKA) in patients with primary Sjögren's syndrome...
  20. ncbi A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
    Michael Groll
    Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universitat Munchen, Lichtenbergstrasse 4, Garching D 85747, Germany
    Nature 452:755-8. 2008
    ..It is thus possible that these bacteria are capable of producing proteasome inhibitors of the syrbactin class...
  21. ncbi Antibody against mutated citrullinated vimentin: a new sensitive marker in the diagnosis of rheumatoid arthritis
    Ernst Wagner
    Institute for Rheumatology of the Kurstadt Baden RSKA Baden of the NOEGKK and Ludwig Boltzmann Cluster Rheumatology, Balneology and Rehabilitation, Forschungsstelle for Epidemiology of Rheumatic Diseases, 2500 Baden, Austria
    Rheumatol Int 29:1315-21. 2009
    ..In a subgroup of 86 RA patients we found a significant correlation between anti-MCV and disease activity. Anti-MCV appears to be an important marker for the diagnosis of RA, and correlates also with disease activity...
  22. ncbi Antibodies to citrullinated vimentin are a specific and sensitive marker for the diagnosis of rheumatoid arthritis
    Hannah Poulsom
    Division of Immunology, Hammersmith Hospitals NHS Trust, and Kennedy Institute of Rheumatology, Imperial College, London, UK
    Clin Rev Allergy Immunol 34:4-10. 2008
    ..Antibodies to citrullinated vimentin were first described in 1994 as a highly specific marker for RA (anti-Sa). However, no easily performed assay for these antibodies has been available...
  23. pmc Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels
    E Bourinet
    Physiopathologie des Canaux Ioniques, Institut de Genetique Humaine, CNRS UPR1142, 34396 Montpellier Cedex 5, France
    Biophys J 81:79-88. 2001
    ..We conclude that SNX482 does not exhibit unequivocal specificity for R-type channels, but highly effectively antagonizes their activation...
  24. pmc Clinical utility of the anti-CCP assay in patients with rheumatic diseases
    D M Lee
    Department of Medicine, Division of Rheumatology, Immunology and Allergy Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Rheum Dis 62:870-4. 2003
    ..To determine the frequency of antibodies to cyclic citrullinated peptides (CCP) in a group of patients with a diversity of rheumatic diseases...
  25. pmc Autoantibody profile in rheumatoid arthritis during long-term infliximab treatment
    Francesca Bobbio-Pallavicini
    Department of Rheumatology University of Pavia, IRCCS Policlinico S, Matteo, Pavia, Italy
    Arthritis Res Ther 6:R264-72. 2004
    ..Also, the evolution of RF titres and that of anti-CCP antibody titres differed during long-term infliximab therapy...
  26. pmc Biocontrol of Bacillus subtilis against infection of Arabidopsis roots by Pseudomonas syringae is facilitated by biofilm formation and surfactin production
    Harsh Pal Bais
    Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, Colorado 80523 1173, USA
    Plant Physiol 134:307-19. 2004
    ..syringae. Our results collectively indicate that upon root colonization, B. subtilis 6051 forms a stable, extensive biofilm and secretes surfactin, which act together to protect plants against attack by pathogenic bacteria...
  27. ncbi Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis
    S Bas
    Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Rheumatology (Oxford) 42:677-80. 2003
  28. ncbi Caspofungin: the first representative of a new antifungal class
    Valerie Letscher-Bru
    Institut de Parasitologie et de Pathologie Tropicale, Faculte de Medecine, 3 Rue Koeberle, 67000 Strasbourg, France
    J Antimicrob Chemother 51:513-21. 2003
    ..Further studies are required to define the exact role of caspofungin in the antifungal armamentarium...
  29. ncbi Caspofungin
    Stanley C Deresinski
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA, 95128, USA
    Clin Infect Dis 36:1445-57. 2003
    ..Caspofungin is an important addition to the antifungal pharmacopoeia...
  30. ncbi Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin
    Vidmantas Petraitis
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 187:1834-43. 2003
    ..The combination of an antifungal triazole and echinocandin may represent a new strategy for treatment of invasive pulmonary aspergillosis...
  31. ncbi The iturin and fengycin families of lipopeptides are key factors in antagonism of Bacillus subtilis toward Podosphaera fusca
    Diego Romero
    Departamento de Microbiologia, Facultad de Ciencias, Universidad de Malaga, Campus Universitario de Teatinos s n, E 29071 Malaga, Spain
    Mol Plant Microbe Interact 20:430-40. 2007
    ..Taken together, our data have allowed us to conclude that the iturin and fengycin families of lipopeptides have a major role in the antagonism of B. subtilis toward P. fusca...
  32. ncbi Partial surgical removal of growth hormone-secreting pituitary tumors enhances the response to somatostatin analogs in acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:85-92. 2006
    ..Surgery is a cornerstone in the treatment of acromegaly, but its efficacy in large, invasive tumors is scant...
  33. pmc Cyanobactins-ribosomal cyclic peptides produced by cyanobacteria
    Kaarina Sivonen
    Department of Food and Environmental Sciences, Division of Microbiology, Viikki Biocenter, University of Helsinki, Helsinki, P O Box 56, Viikinkaari 9, FIN 00014, Finland
    Appl Microbiol Biotechnol 86:1213-25. 2010
    Cyanobactins are small cyclic peptides that are produced by a diverse selection of cyanobacteria living in symbioses as well as terrestrial, marine, or freshwater environments...
  34. ncbi Expression of the nodularin synthetase genes in the Baltic Sea bloom-former cyanobacterium Nodularia spumigena strain AV1
    Sara Jonasson
    Department of Botany, Stockholm University, Stockholm, Sweden
    FEMS Microbiol Ecol 65:31-9. 2008
    ..In contrast to the shifts in expression, the intracellular and extracellular nodularin concentrations did not vary significantly during the treatments...
  35. ncbi Cytotoxic and peptidase inhibitory activities of selected non-hepatotoxic cyclic peptides from cyanobacteria
    Anja Bubik
    Department of Genetic Toxicology, National Institute of Biology, Vecna pot 111, POB 141, SI 1001 Ljubljana, Slovenia
    Biol Chem 389:1339-46. 2008
    ..Two main groups of cyclic peptides, depsipeptides and ureido linkage-containing peptides, reportedly inhibit serine peptidases...
  36. ncbi Anti-citrullinated protein/peptide antibodies (ACPA) in rheumatoid arthritis: specificity and relation with rheumatoid factor
    B Vander Cruyssen
    Department of Rheumatology, Ghent University Hospital, B 9000 Gent, Belgium
    Autoimmun Rev 4:468-74. 2005
    ..Indeed, both antibody systems have a different association with specific RA features like extra-articular manifestations, a different association with the HLA shared epitope and, behave differently following anti-TNF therapy...
  37. ncbi Combinations of antifungal agents in therapy--what value are they?
    Manuel Cuenca-Estrella
    Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo km 2, 28220 Majadahonda, Madrid, Spain
    J Antimicrob Chemother 54:854-69. 2004
    ..However, combination therapy could be an alternative to monotherapy for patients with invasive infections that are difficult to treat, such as those due to multi-resistant species and for those who fail to respond to standard treatment...
  38. ncbi Treatment with caspofungin in immunocompromised paediatric patients: a multicentre survey
    Andreas H Groll
    Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Paediatric Haematology Oncology, Children s University Hospital, Muenster, Germany
    J Antimicrob Chemother 57:527-35. 2006
    ..We conducted a multicentre retrospective survey to obtain data on immunocompromised paediatric patients considered to require caspofungin therapy...
  39. ncbi Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status
    So Young Bang
    Hospital for Rheumatic Diseases, Hanyang University, Seoul, South Korea
    Arthritis Rheum 62:369-77. 2010
  40. pmc Design of cyclic peptides that bind protein surfaces with antibody-like affinity
    Steven W Millward
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    ACS Chem Biol 2:625-34. 2007
    ..Using this library, we have designed a number of high-affinity, redox-insensitive, cyclic peptides that target the signaling protein G alpha i1...
  41. pmc Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles
    S P Linn-Rasker
    Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, Netherlands
    Ann Rheum Dis 65:366-71. 2006
    ..To study the gene-environment interaction of tobacco exposure and shared epitope on autoantibodies in patients with rheumatoid arthritis and undifferentiated arthritis...
  42. ncbi Evaluation of a (99m)Tc-labeled cyclic RGD tetramer for noninvasive imaging integrin alpha(v)beta3-positive breast cancer
    Shuang Liu
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907 2051, USA
    Bioconjug Chem 18:438-46. 2007
    ..i. The high tumor uptake and fast renal excretion make [99mTc(HYNIC-tetramer)(tricine)(TPPTS)] a promising radiotracer for noninvasive imaging of the integrin alphavbeta3-positive tumors by SPECT...
  43. ncbi Formation of diagnostic product ions from cyanobacterial cyclic peptides by the two-bond fission mechanism using ion trap liquid chromatography/multi-stage mass spectrometry
    Tsuyoshi Mayumi
    Graduate School of Environmental and Human Science, Meijo University, Tempaku, Nagoya 468 8503, Japan
    Rapid Commun Mass Spectrom 21:1025-33. 2007
    ..However, in the case of cyclic peptides, the fragmentation pattern is complicated because the cleavages occur randomly and product ions are generated ..
  44. ncbi Marine bacteria associated with sponge as source of cyclic peptides
    Salvatore De Rosa
    Istituto di Chimica Biomolecole CNR, Via Campi Flegrei, 34, I 80078 Pozzuoli, Naples, Italy
    Biomol Eng 20:311-6. 2003
    ..Several diketopiperazines were isolated from both bacteria and the hypothesis of their role in the bacterial-spongy interaction is discussed...
  45. ncbi Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula
    Maya Mitova
    Istituto di Chimica Biomolecole CNR, Via Campi Flegrei 34, I 80078 Pozzuoli, Naples, Italy
    J Nat Prod 67:1178-81. 2004
    Two new cyclic peptides, cyclo-(glycyl-L-seryl-L-prolyl-L-glutamyl) and cyclo-(glycyl-L-prolyl-L-glutamyl), have been isolated from the cell extract of a Ruegeria strain associated with cell cultures of Suberites domuncula...
  46. ncbi Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides
    Taha Rezai
    Department of Chemistry and Biochemistry, University of California at Santa Cruz, Santa Cruz, CA 95064, USA
    J Am Chem Soc 128:14073-80. 2006
    We report an atomistic physical model for the passive membrane permeability of cyclic peptides. The computational modeling was performed in advance of the experiments and did not involve the use of "training data"...
  47. ncbi MicroPET imaging of brain tumor angiogenesis with 18F-labeled PEGylated RGD peptide
    Xiaoyuan Chen
    PET Imaging Science Center, Department of Radiology, University of Southern California Keck School of Medicine, 1510 San Pablo St, Suite 350, CA 90033, Los Angeles, USA
    Eur J Nucl Med Mol Imaging 31:1081-9. 2004
    ..In conclusion, PEGylation suitably modifies the physiological behavior of the RGD peptide. [18F]FB-PEG-RGD gave improved tumor retention and in vivo kinetics compared with [18F]FB-RGD...
  48. ncbi Micro-PET imaging of alphavbeta3-integrin expression with 18F-labeled dimeric RGD peptide
    Xiaoyuan Chen
    University of Southern California, Los Angeles, USA
    Mol Imaging 3:96-104. 2004
    ..5 +/- 0.8. The synergistic effect of polyvalency and improved pharmacokinetics may be responsible for the superior imaging characteristics of [18F]FB-E[c(RGDyK)]2...
  49. pmc Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis
    Gilles Boire
    Department of Medicine, Division of Rheumatology, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Arthritis Res Ther 7:R592-603. 2005
  50. pmc Diagnostic performances of anti-cyclic citrullinated peptides antibody and antifilaggrin antibody in Korean patients with rheumatoid arthritis
    Suk Woo Choi
    Department of Laboratory Medicine, Eulji University, School of Medicine, Daejeon, Korea
    J Korean Med Sci 20:473-8. 2005
  51. ncbi Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti-cyclic citrullinated peptide antibody
    T R Mikuls
    Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Arthritis Rheum 50:3776-82. 2004
    ..To examine the association of treatment response and disease duration with changes in rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody levels among patients with rheumatoid arthritis (RA)...
  52. ncbi Anti-cyclic citrullinated peptide antibody in rheumatoid arthritis: relation with disease aggressiveness
    N del Val del Amo
    Rheumatology Department, Navarra Hospital, Pamplona, Spain
    Clin Exp Rheumatol 24:281-6. 2006
    ..To analyse the value of the anti-cyclic citrullinated peptide antibody (anti-CCP) in patients with rheumatoid arthritis (RA) as a prognostic factor, as well as its relationship with disease activity...
  53. pmc Systemic antibacterial activity of novel synthetic cyclic peptides
    Veronique Dartois
    Novartis Institute for Tropical Diseases, 10 Biopolis Rd, 05 01 Chromos, Singapore 138670
    Antimicrob Agents Chemother 49:3302-10. 2005
    b>Cyclic peptides with an even number of alternating d,l-alpha-amino acid residues are known to self-assemble into organic nanotubes...
  54. ncbi Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study
    W H Bos
    Jan van Breemen Instituut, Amsterdam, The Netherlands
    Ann Rheum Dis 69:490-4. 2010
    ..Anti-citrullinated protein antibodies (ACPA) are associated with increased risk for rheumatoid arthritis...
  55. ncbi Imaging of delayed-type hypersensitivity reaction by PET and 18F-galacto-RGD
    Bernd J Pichler
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    J Nucl Med 46:184-9. 2005
    Radiolabeled cyclic peptides containing the amino acid sequence arginine-glycine-aspartate (RGD peptides) have successfully been used to image the expression of the alpha(v)beta(3) integrin in malignant tumors...
  56. ncbi Rheumatoid factor and antibodies to cyclic citrullinated Peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis
    Annemarie L M A Jansen
    Jan van Breemen Instituut and the Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands
    J Rheumatol 29:2074-6. 2002
  57. ncbi Optimalization and cost management of lanreotide-Autogel therapy in acromegaly
    Pascale Abrams
    Department of Endocrinology, University Hospital of Antwerp, Wilrijkstraat 1, B 2650 Antwerp, Belgium
    Eur J Endocrinol 157:571-7. 2007
    ..Lanreotide-Autogel is a depot formulation of the somatostatin analog lanreotide used in the treatment of acromegaly. We investigated whether prolonging or shortening the interval between injections would offer any benefit...
  58. ncbi Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation
    Georgette Thumshirn
    Institut fur Organische Chemie und Biochemie, Technische Universität Munich, Lichtenbergstrasse 4, 85747 Garching, Germany
    Chemistry 9:2717-25. 2003
    ..The conjugates were obtained in good yield without the need of a protection strategy and under mild conditions...
  59. ncbi Role of lipopeptides produced by Bacillus subtilis GA1 in the reduction of grey mould disease caused by Botrytis cinerea on apple
    Y Toure
    Service de Technologie Microbienne, CWBI, Universite de Liege, Liege, Belgium
    J Appl Microbiol 96:1151-60. 2004
    ..Test of Bacillus subtilis strain GA1 for its potential to control grey mould disease of apple caused by Botrytis cinerea...
  60. ncbi Argyrins, immunosuppressive cyclic peptides from myxobacteria. II. Structure elucidation and stereochemistry
    Larissa Vollbrecht
    GBF, Gesellschaft fur Biotechnologische Forschung mbH, Abteilung Naturstoffchemie, Braunschweig, Germany
    J Antibiot (Tokyo) 55:715-21. 2002
    ..Argyrins A and B are identical with the antibiotics A21459 A and B, whose structures are revised with respect to 4'-methoxytryptophan...
  61. pmc Combination treatment with Grb7 peptide and Doxorubicin or Trastuzumab (Herceptin) results in cooperative cell growth inhibition in breast cancer cells
    S C Pero
    Department of Surgery, Vermont Cancer Comprehensive Center, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    Br J Cancer 96:1520-5. 2007
    ..This Grb7 peptide has potential to be developed as a therapeutic agent alone, in combination with traditional chemotherapy, or in combination with other targeting molecules...
  62. ncbi Largamides A-H, unusual cyclic peptides from the marine cyanobacterium Oscillatoria sp
    Alberto Plaza
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0820, USA
    J Org Chem 71:6898-907. 2006
    ..Largamides D-G (4-7) inhibited chymotrypsin with IC(50) values ranging between 4 and 25 microM...
  63. ncbi Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population
    Ann W Morgan
    Leeds Musculoskeletal Biomedical Research Unit, Institute of Molecular Medicine, University of Leeds, St James University Hospital, Leeds, UK
    Arthritis Rheum 60:2565-76. 2009
    ..To define interactions between the HLA-DRB1 shared epitope (SE), PTPN22, and smoking in cyclic citrullinated peptide (CCP) antibody- and rheumatoid factor (RF)-positive and -negative rheumatoid arthritis (RA)...
  64. pmc In vitro activity of caspofungin against Candida albicans biofilms
    Stefano P Bachmann
    Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Antimicrob Agents Chemother 46:3591-6. 2002
    ..albicans. Together these findings indicate that caspofungin displays potent activity against C. albicans biofilms in vitro and merits further investigation for the treatment of biofilm-associated infections...
  65. pmc Efficacy of caspofungin alone and in combination with voriconazole in a Guinea pig model of invasive aspergillosis
    William R Kirkpatrick
    Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229 3900, USA
    Antimicrob Agents Chemother 46:2564-8. 2002
    ..The combinations of CAS plus VRC were highly effective in this model and should be further evaluated for use against invasive aspergillosis...
  66. ncbi The immunopathogenesis of rheumatoid arthritis
    John B Imboden
    Department of Medicine, University of California, and Division of Rheumatology, San Francisco General Hospital, San Francisco, CA 94110, USA
    Annu Rev Pathol 4:417-34. 2009
    ..There is a strong association between shared-epitope-expressing HLA-DRB1 alleles and the development of rheumatoid arthritis associated with autoimmunity to citrullinated protein antigens...
  67. ncbi Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis
    Snaevar Sigurdsson
    Uppsala University, Uppsala, Sweden
    Arthritis Rheum 56:2202-10. 2007
    ..To determine whether genetic variants of the interferon regulatory factor 5 (IRF-5) and Tyk-2 genes are associated with rheumatoid arthritis (RA)...
  68. pmc Halogenated cyclic peptides isolated from the sponge Corticium sp
    Damian W Laird
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Nat Prod 70:741-6. 2007
    ..led to the isolation of the known active alkaloid steroid plakinamine A and two new halogenated cyclic peptides, corticiamide A (1) and cyclocinamide B (2)...
  69. pmc Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans
    Teresa T Liu
    Department of Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, and Le Bonheur Children s Medical Center, Room 304 West Patient Tower, Children s Foundation Research Center, 50 North Dunlap Street, Memphis, TN 38163, USA
    Antimicrob Agents Chemother 49:2226-36. 2005
    ..Genes responding similarly to two or more drugs were also identified. These data shed new light on the effects of these classes of antifungal agents on C. albicans...
  70. ncbi Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia
    Thomas J Walsh
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 351:1391-402. 2004
    ..Caspofungin, a member of the new echinocandin class of compounds, may be an effective alternative that is better tolerated than amphotericin B...
  71. ncbi Cyclic peptides from an endophytic fungus obtained from a mangrove leaf (Kandelia candel)
    Huarong Huang
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People s Republic of China
    J Nat Prod 70:1696-9. 2007
    ..Both of these new cyclo-depsipeptides were found to contain one d-amino acid. In the MTT bioassay, 1962A (1) showed weak activity against human breast cancer MCF-7 cells...
  72. ncbi Comparison of caspofungin and amphotericin B for invasive candidiasis
    Jorge Mora-Duarte
    Neeman ICIC and Hospital Mexico, C C S S, San Jose, Costa Rica
    N Engl J Med 347:2020-9. 2002
    ..Caspofungin is an echinocandin agent with fungicidal activity against candida species. We performed a double-blind trial to compare caspofungin with amphotericin B deoxycholate for the primary treatment of invasive candidiasis...
  73. ncbi Nodularin uptake by seafood during a cyanobacterial bloom
    P G Van Buynder
    Victorian Department of Human Services, GPO Box 1670N, Melbourne, VIC 3001
    Environ Toxicol 16:468-71. 2001
    ..Nodularin concentrations in the flesh of finfish remained low. Boiling the seafood redistributed toxin between viscera and flesh. The results were used to restrict some seafood harvesting...
  74. pmc Determination of oligopeptide diversity within a natural population of Microcystis spp. (cyanobacteria) by typing single colonies by matrix-assisted laser desorption ionization-time of flight mass spectrometry
    J Fastner
    Biotechnology Center and Max Vollmer Institute, Technical University Berlin, 10587 Berlin, Germany
    Appl Environ Microbiol 67:5069-76. 2001
    ..It could be demonstrated that the typing of single colonies by MALDI-TOF MS may be a valuable tool for ecological studies of the genus Microcystis as well as in early warning of toxic cyanobacterial blooms...
  75. ncbi Pharmacokinetics and population pharmacodynamic analysis of lanreotide Autogel
    Joseph M Cendros
    Pharmacokinetics and Metabolism Service, Ipsen Pharma S A, 08980 Saint Feliu Llobregat, Barcelona, Spain
    Metabolism 54:1276-81. 2005
    ..206 ng/mL, showing a high sensitivity to lanreotide, with a predictably high interpatient variability of 200.75% reflecting the range of dosing regimens needed to control GH...
  76. ncbi Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis
    Shinji Tanaka
    Department of Hepato Biliary Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    J Natl Cancer Inst 98:491-8. 2006
    ..In this study, we evaluated Grb7 protein as a molecular target of therapy for metastatic pancreatic cancer...
  77. pmc Widespread occurrence and lateral transfer of the cyanobactin biosynthesis gene cluster in cyanobacteria
    Niina Leikoski
    Department of Applied Chemistry and Microbiology, University of Helsinki, Viikki Biocenter, Helsinki, Finland
    Appl Environ Microbiol 75:853-7. 2009
    Cyanobactins are small cyclic peptides produced by cyanobacteria. Here we demonstrate the widespread but sporadic occurrence of the cyanobactin biosynthetic pathway...
  78. ncbi Echinocandin antifungal drugs
    David W Denning
    Education and Research Centre, Wythenshawe Hospital, Southmoor Road, M23 9LT, Manchester, UK
    Lancet 362:1142-51. 2003
    ..Absence of antagonism in combination with other antifungal drugs suggests that combination antifungal therapy could become a general feature of the echinocandins, particularly for invasive aspergillosis...
  79. pmc Long-term (up to 18 years) effects on GH/IGF-1 hypersecretion and tumour size of primary somatostatin analogue (SSTa) therapy in patients with GH-secreting pituitary adenoma responsive to SSTa
    Jean Christophe Maiza
    Department of Endocrinology, CHU Rangueil, 31059 Toulouse, France
    Clin Endocrinol (Oxf) 67:282-9. 2007
    ..The role of somatostatin analogues (SSTa) in the treatment of acromegaly...
  80. pmc Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors
    Matthew S Kelker
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02903, USA
    J Mol Biol 385:11-21. 2009
    ..Furthermore, since tautomycin is a linear non-peptide-based toxin, our reported structure will aid the design of lead compounds for novel PP1-specific pharmaceuticals...
  81. pmc Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP)
    K Forslind
    Section of Rheumatology, Helsingborgs Iasarett, Helsingborg, Sweden
    Ann Rheum Dis 63:1090-5. 2004
    ..To investigate the role of anti-cyclic citrullinated peptide antibody (anti-CCP) for the prediction of radiological outcome in patients with early rheumatoid arthritis...
  82. pmc Cyclic coordinate descent: A robotics algorithm for protein loop closure
    Adrian A Canutescu
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Protein Sci 12:963-72. 2003
    ..It succeeds in closing loops in a large test set 99.79% of the time, and fails occasionally only for short, highly extended loops. It is very fast, closing loops of length 8 in 0.037 sec on average...
  83. pmc Highly diverse cyanobactins in strains of the genus Anabaena
    Niina Leikoski
    Lehrbereich Mikrobielle Genetik, Eberhard Karls Universitat Tubingen, 72076 Tubingen, Germany
    Appl Environ Microbiol 76:701-9. 2010
    Cyanobactins are small, cyclic peptides recently found in cyanobacteria...
  84. ncbi Neopetrosiamides, peptides from the marine sponge Neopetrosia sp. that inhibit amoeboid invasion by human tumor cells
    David E Williams
    Department of Chemistry, Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1
    Org Lett 7:4173-6. 2005
    ..collected in Papua New Guinea. The structures of the neopetrosiamides were elucidated by analysis of MS and NMR data and confirmed by chemical degradation...
  85. ncbi Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor
    Lior Zilberberg
    Molecular Angiogenesis Laboratory, INSERM E 0113, Universite de Bordeaux 1, 33405 Talence, France
    J Biol Chem 278:35564-73. 2003
    ..Taken together, these results suggest that cyclo-VEGI is an attractive candidate for the development of novel angiogenesis inhibitor molecules useful for the treatment of cancer and other angiogenesis-related diseases...
  86. ncbi Exploring the conformational space of cyclic peptides by a stochastic search method
    Anwar Rayan
    Department of Medicinal Chemistry and Natural Products, David R Bloom Center for Pharmacy, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Mol Graph Model 22:319-33. 2004
    A stochastic search algorithm is applied in order to probe the conformations of cyclic peptides. The search is conducted in two stages...
  87. pmc Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides
    Jan H van Maarseveen
    Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Org Lett 7:4503-6. 2005
  88. ncbi Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/dopaminergic chimeric ligand
    Song Guang Ren
    Cedars Sinai Research Institute, University of California School of Medicine, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 88:5414-21. 2003
    ..The SRIF/DA chimeric molecule, BIM-23A387, represents a novel tool for effective drug treatment of acromegaly and for prolactinomas otherwise resistant to dopaminergic therapy...
  89. pmc Functional haplotypes of PADI4: relevance for rheumatoid arthritis specific synovial intracellular citrullinated proteins and anticitrullinated protein antibodies
    T Cantaert
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    Ann Rheum Dis 64:1316-20. 2005
    ..Haplotypes of PADI4, encoding for a citrullinating enzyme, were associated with rheumatoid arthritis in a Japanese population. It was suggested they were related to the presence of anticitrullinated protein antibodies (ACPA)...
  90. pmc The microcystin composition of the cyanobacterium Planktothrix agardhii changes toward a more toxic variant with increasing light intensity
    Linda Tonk
    Aquatic Microbiology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, Nieuwe Achtergracht 127, 1018 WS Amsterdam, The Netherlands
    Appl Environ Microbiol 71:5177-81. 2005
    ..Since microcystin-DeLR is considerably more toxic than microcystin-DeRR, this implies that P. agardhii becomes more toxic at high light intensities...
  91. ncbi Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula
    H Luesch
    Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    J Am Chem Soc 123:5418-23. 2001
    ..Apratoxin A (1) possesses IC(50) values for in vitro cytotoxicity against human tumor cell lines ranging from 0.36 to 0.52 nM; however, it was only marginally active in vivo against a colon tumor and ineffective against a mammary tumor...
  92. ncbi "Non-toxic" cyclic peptides induce lysis of cyanobacteria-an effective cell population density control mechanism in cyanobacterial blooms
    B Sedmak
    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology Ljubljana, Vecna pot 111, 1000, Ljubljana, Slovenia
    Microb Ecol 56:201-9. 2008
    ..aeruginosa cell line without lytic effects. Nevertheless, the presence of "non-toxic" cyclic peptides of cyanobacterial origin can induce lysis of these previously infected cells...
  93. ncbi Probing diameter-selective solubilisation of carbon nanotubes by reversible cyclic peptides using molecular dynamics simulations
    S R Friling
    Dept of Chemistry and Centre for Scientific Computing, University of Warwick, Coventry, U K
    Nanoscale 2:98-106. 2010
    Molecular dynamics simulations are used to explore the encapsulation behaviour of reversible cyclic peptides when adsorbed onto single-walled carbon nanotubes (CNTs) in aqueous solution...
  94. ncbi Molecular cloning, pharmacological characterization, and brain mapping of the melanocortin 4 receptor in the goldfish: involvement in the control of food intake
    Jose Miguel Cerdá-Reverter
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, T6G 2E9 Canada
    Endocrinology 144:2336-49. 2003
  95. ncbi Association of anti-cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis
    Seongwon Cha
    Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
    Arthritis Rheum 56:1454-63. 2007
    ..This study was undertaken to determine whether anti-CCP levels are associated with PADI4 haplotypes and/or SE alleles in Korean patients with RA...
  96. ncbi Localization studies of ioactive cyclic peptides in the ascidian Lissoclinum patella
    Christine E Salomon
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0212, USA
    J Nat Prod 65:689-92. 2002
    A Palauan specimen of the ascidian Lissoclinum patella contained the cyclic peptides patellamides A-C. In contrast to previous reports concerning the location of cyclic peptides in L. patella and L...
  97. pmc Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models
    Joshua A Kritzer
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Nat Chem Biol 5:655-63. 2009
    Phage display has demonstrated the utility of cyclic peptides as general protein ligands but cannot access proteins inside eukaryotic cells...
  98. ncbi Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis
    Johan Maertens
    Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium
    Cancer 107:2888-97. 2006
    ..Interest remains as to whether caspofungin, in combination with other antifungal classes, can improve the efficacy against IA...
  99. ncbi Cyclic peptides from Oldenlandia affinis DC. Molecular and biological properties
    Lorents Gran
    Department of Biochemistry Biotechnology Center of Oslo, University of Oslo, N 0316 Oslo
    Chem Biodivers 5:2014-22. 2008
    ..All three peptides showed hemolytic activity on human blood, and were tested for antibiotic effect against E. coli, Staphylococcus aureus, and Hemophilus influenzae...
  100. ncbi NMR analysis of G7-18NATE, a nonphosphorylated cyclic peptide inhibitor of the Grb7 adapter protein
    C J Porter
    School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Perth, WA, Australia
    Biopolymers 88:174-81. 2007
    ..This suggests that there is scope for increasing the rigidity of the peptide that may enhance its binding affinity and specificity for Grb7...
  101. ncbi Modified low molecular weight cyclic peptides as mimetics of BDNF with improved potency, proteolytic stability and transmembrane passage in vitro
    Jordan M Fletcher
    The Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia
    Bioorg Med Chem 17:2695-702. 2009
    ..Select members of this second generation of compounds showed improved biological activity, stability in plasma, and an ability to cross model biological membranes...

Research Grants63

    CHARLES SIH; Fiscal Year: 2001
    ..Many heterocyclic products, including alkaloids, cyclic peptides, thyroid hormones, and glycopeptide antibiotics are biosynthesized via enzyme-catalyzed oxidative coupling...
  2. Aminoglycoside microbicides restore natural expression of anti-HIV-1 retrocyclins
    Alexander M Cole; Fiscal Year: 2010
    ..Certain nonhuman primates also produce ?-defensins - 18 residue cyclic peptides that act as HIV-1 entry inhibitors...
  3. Aminoglycoside microbicides restore natural expression of anti-HIV-1 retrocyclins
    ALEXANDER MICHAEL COLE; Fiscal Year: 2013
    ..Certain nonhuman primates also produce ?-defensins - 18 residue cyclic peptides that act as HIV-1 entry inhibitors...
  4. Glycopeptide Complexes with Bacterial Cell Walls by REDOR NMR
    Jacob Schaefer; Fiscal Year: 2013
    ..used in the clinic;and (iii) intermediate-resistant staph strain Mu50 whose peptidoglycan-thickened cell wall resists treatment by both vancomycin and oritavancin but appears to be susceptible to at least one of the cyclic peptides.
    Jonathan Walton; Fiscal Year: 2013
    ..The fourth aim is to use this experimental system to synthesize in vivo new cyclic peptides based on the Amanita toxin scaffold...
  6. XLF in double-strand break repair and chemo/radiosensitization
    Lawrence F Povirk; Fiscal Year: 2013
    ..selection technique, mRNA display, will be used to isolate small (Mr 1000-2000), cell-penetrating, drug-like cyclic peptides that bind to XRCC4 at its interface with XLF...
  7. Rescuing the anti-HIV activity of APOBEC3G with small-molecule chaperons
    Sergey N Savinov; Fiscal Year: 2010
    ..2: We will confirm and characterize Vif-degrading and/or A3G-protecting activities of the selected backbone cyclic peptides using a series of biochemical and cellular assays...
  8. Thiazolyl peptide analogs that provide insight into antibiotic targeting
    TRAVIS SCOTT YOUNG; Fiscal Year: 2012
    ..proposed herein will take an unprecedented leap in the ability to create, understand, and screen libraries of cyclic peptides. This work has the potential to create thiazolyl peptides with novel spectrums of activity through the ..
  9. Drugging the Undruggable: Targeting Transcription Factors with Small Cyclic Pept
    Joshua A Kritzer; Fiscal Year: 2010
    ..Provided by the applicant) Abstract: Drugging the Undruggable: Targeting Transcription Factors with Small Cyclic Peptides Transcription factors such as Myc, STAT3 and HSF1 represent key targets for novel cancer therapies...
  10. Synthesis and discovery of biologically active cell-permeable cyclic peptides
    R Scott Lokey; Fiscal Year: 2012
    b>Cyclic peptides have been explored as ligands against a wide variety of biological targets. They are relatively easy to synthesize, and, at the same time, exhibit a degree of complexity unrivaled by most other classes of small molecules...
  11. Small Molecule Receptors for Membrane Lipids
    Jianmin Gao; Fiscal Year: 2013
    ..We hypothesize that small cyclic peptides could serve as an effective and versatile scaffold for designing low molecular weight receptors for membrane ..
  12. Rapid Generation of Isoform-Selective Histone Deacetylase Inhibitors
    Joshua A Kritzer; Fiscal Year: 2012
    ..takes advantage of a novel technology developed by the Principal Investigator to rapidly screen millions of cyclic peptides in the yeast Saccharomyces cerevisiae for inhibitors of enzyme activity or protein-protein interactions...
    Dale L Boger; Fiscal Year: 2013
  14. Directed Evolution of Selective Protease Inhibitors with an Expanded Genetic Code
    Jennifer L Furman; Fiscal Year: 2013
    ..encoding an unnatural amino acid warhead for targeting the MT-SP1 active site and 2) Phage display of cyclic peptides for directed evolution using an expanded genetic code...
  15. Virus Electrodes for Fungal Pathogen Detection
    Gary Fujii; Fiscal Year: 2009
    ..Recent work in the laboratory of Professor Margo Moore of Simon Fraser University has identified cyclic peptides of the siderophore family as promising targets for the early detection and diagnosis of aspergillosis...
  16. Modulating the BBB to Improve Drug Delivery to the Brain
    Teruna J Siahaan; Fiscal Year: 2013
    ..Third, the BBB modulatory activity of HAV peptides will be improved by forming cyclic peptides. Fourth, the mechanism of action of HAV peptide in modulating cadherin-cadherin interactions in the ..
  17. Peptide effectors of virulence factor production in Vibrio cholerae
    JAMES EDWARD BINA; Fiscal Year: 2012
    ..In this application we present preliminary data to show that cyclic peptides function as quorum sensing independent signals that effect virulence gene regulation...
  18. Understanding, Predicting, and Engineering Membrane Permeability
    Matthew P Jacobson; Fiscal Year: 2012
    ..2. Interrogate key aspects of membrane permeation using cyclic peptides, and use this knowledge to design highly permeable cyclic peptides...
  19. Bicyclic Peptides as Inhibitors of Critical Protein-Protein Interactions
    Justin S Quartararo; Fiscal Year: 2013
    ..Conformational restriction of linear and cyclic peptides has been shown to be an effective tool in the development of potent and selective biological probes...
  20. Novel Antifungals by Engineering the AbA NRPS gene
    Ake P Elhammer; Fiscal Year: 2012
    ..Production of structurally altered cyclic peptides by engineering of a fungal NRPS complex has not been reported previously...
    M Ghadiri; Fiscal Year: 2009
    ..5) Design, synthesis, selection, and characterization of antibacterial and antiviral self- assembling cyclic peptides, including the use of directed combinatorial libraries of cyclic D,L-a-, D,L-a- glyco-, and a,p-peptides;..
  22. Characterizing Natural Product Permeability and Bioactivity
    KATRINA WALDEN LEXA; Fiscal Year: 2013
    ..Studies of cyclosporine and other cyclic peptides have demonstrated that their passive permeability is correlated to intramolecular hydrogen bond formation in ..
  23. Studies in Amide and Peptide Synthesis
    ..of amides derived from nonnatural amino acids, common constituents of biologically active linear and cyclic peptides that have been isolated from natural sources, is a central theme...
  24. Structure-Based Design of Eph Receptor Antagonists
    Longqin Hu; Fiscal Year: 2005
    ..Preliminary studies with simple disulfide-linked cyclic peptides indicate that short conformationally restricted cyclic peptides containing the loop residues could bind to ..
  25. New approaches to sequencing of complex peptides.
    Pavel A Pevzner; Fiscal Year: 2010
    ..efforts, we will harvest a set of orphan gene clusters from marine actinomycetes to generate a library of cyclic peptides. The algorithms developed in this proposal will be used to fully characterize this cyclic imine library...
  26. A Bacitracin derivative for systemic use
    Ake Elhammer; Fiscal Year: 2007
    ..Several currently used antibacterial drugs belong to a group of natural products compounds known as cyclic peptides. Cyclic peptides are isolated from microorganisms such as bacteria or fungi...
    Charles Scott; Fiscal Year: 2007
    The research program described in this application is focused on development of intracellular libraries of cyclic peptides as sources of molecular diversity for drug discovery and chemical genetics...
  28. The Structural basis of EBV Attachment: CD21 & gp350/220
    Joyce Fingeroth; Fiscal Year: 2005
    ..In Specific Aim 3, (an aim independent of 1 and 2) we will determine whether cyclic peptides that mimic the CD21 epitopes implicated in gp350 interaction by our model can prevent virus attachment in ..
  29. Biocombinatorial Strategies Against Botulinum Toxin
    Kim Janda; Fiscal Year: 2003
    ..We propose "biocombinatorial strategies" developed in our laboratory, which refer to human antibodies and cyclic peptides derived from novel phage-display libraries using various selection techniques, against the threat of BoTox...
  30. Antibody- and peptide-inhibitors of quorum sensing
    Kim Janda; Fiscal Year: 2004
    ..The quorum sensing signaling molecules used by S. aureus are small cyclic peptides, also called autoinducing peptides (AIPs), whose primary structures, i.e...
  31. Antimicrobial targets of intracellular cyclic peptides
    Ernesto Abel Santos; Fiscal Year: 2007
    ..objective of this proposal is to detect essential bacterial genes, while simultaneously obtaining stable, cyclic peptides that inhibit their function(s)...
    FRED KARUSH; Fiscal Year: 1990
    ..A comparison will also be made between linear and cyclic peptides with respect to immunogeneicity and affinity...
  33. Nanoparticles Targeting Pancreatic Cancer
    Dennis Hallahan; Fiscal Year: 2009
    ..We have screened 12 different peptide libraries that consist of varying lengths of both linear and cyclic peptides displayed upon phage...
  34. Peptide-grafting lens to prevent bacterial adhesion and biofilm formation
    YANLEI LIU; Fiscal Year: 2006
    ..Hypothesis: Small cyclic peptides can block bacterial adhesion and prevent biofilm formation at an early stage...
    DEANNA LONG; Fiscal Year: 2001
    Description: (Applicant's abstract) Disulfide-bridged cyclic peptides form the base for many popularly used cancer-treatment drugs and hormones such as somatostatin, calcitonins, and oxytocin...
    Michael Levine; Fiscal Year: 1992
    The board and long term objective is to study the structure and conformation details of cyclic peptides in the crystalline state using x-ray crystallographic techniques...
    Stephen Cheley; Fiscal Year: 2004
    ..AlphaHL will be radically remodeled by targeted non-covalent and covalent modifications with cyclodextrins, cyclic peptides, responsive polymers, oligonucleotides and a bipartite chelator...
  38. Structure-function of RNAP inhibitor microcin J25
    Konstantin Severinov; Fiscal Year: 2006
    ..Understanding of MccJ25 maturation may allow to use McjA-based chimeric proteins to construct novel cyclic peptides and or proteins with potentially interesting biological and pharmacological properties.
  39. Computational Methods for Proteins
    Hagai Meirovitch; Fiscal Year: 2003
    ..was developed recently by us and applied successfully to predict the solution structures and populations of cyclic peptides in DMSO. In this project it will be extended to protein loops in water...
    Richard Fine; Fiscal Year: 1991
    ..Our short term goal (Phase I) is to extend the method to molecular dynamics samples of linear and cyclic peptides with side chains in water...
  41. Generation of novel HCV drugs through engineereing of the cssA gene
    Ake Elhammer; Fiscal Year: 2009
    ..The cyclic peptides constitute a class of compounds that have made crucial contributions human health...
  42. Rapid Selection and Evaluation of Cyclic Peptides in Parkinson's Disease Models
    Susan Lindquist; Fiscal Year: 2009
    ..We wish to make use of these models for the identification of molecules with therapeutic potential. Cyclic peptides are a proven class of cellular effector that is largely unexplored as a source of molecular therapeutics...
  43. Modified bacterial system for vivo direction evolution
    Paul Olson; Fiscal Year: 2004 mammalian systems to enable the in vivo evolution of peptide-based therapeutics (such as antibodies, cyclic peptides, and enzymes). These therapeutics will address critical areas such as antiviral and antimicrobial drugs...
    David Krag; Fiscal Year: 2006
    ..Using phage display, we have identified cyclic peptides that bind to Grb7...
    DEANNA LONG; Fiscal Year: 2005
    ..Our Phase I study produced a solid polymer-supported oxidant, termed CLEAR-OX(TM), that successfully forms cyclic peptides. These improved synthetic conditions allow rapid purification through simple filtration...
  46. Isolating cyclic peptide inhibitors of FGAM synthetase
    TODD NAUMANN; Fiscal Year: 2004, SICLOPPS, allows for the generation of plasmid libraries that encode for the production of random cyclic peptides in vivo...
  47. Novel Antifungals by Engineering the AbA NRPS gene
    Ake Elhammer; Fiscal Year: 2004
    ..pullulans to produce cyclic peptides that are, or can be developed into, well-tolerated, potent, broad spectrum antifungal drugs, using no ..
  48. Novel prostate homing peptides as potential diagnostics
    Catherine Woods; Fiscal Year: 2001
    ..prostate specific peptides by screening the CX3CX3C and CX6C phage display libraries, since these yield cyclic peptides that may exhibit higher binding affinities...
  49. New Inhibitors of HIV Replication
    Gabriele Varani; Fiscal Year: 2005
    ..Use structure-based drug design methods to reduce the cyclic peptides to potent small molecule mimics using peptidomimetic concepts...
  50. Calcineurin and Aspergillus fumigatus Pathogenesis
    WILLIAM STEINBACH; Fiscal Year: 2008
    ..I will also test the non-immunosuppressive calcineurin inhibitor analogs to decrease the total level of immunosuppression and therefore increase the overall antifungal efficacy of exploiting the calcineurin pathway. ..
  51. Novel Ternary Ligand 99m Tc-Nitrido Complexes as Heart Imaging Agents
    Shuang Liu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  52. Novel Cationic 99mTc Complexes for Heart Imaging
    Shuang Liu; Fiscal Year: 2006
    ..Successful development of new 99mTc perfusion imaging agents will have a profound impact on diagnostic evaluation, risk stratification, and therapeutic decision-making in patients with CAD. ..
  53. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  54. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
  55. Somatostatin Receptor-Selective Agonists and Antagonists
    Jean Rivier; Fiscal Year: 2006
    ..abstract_text> ..
  56. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. Symbiont Models for Natural Product Pathway Manipulation
    Eric W Schmidt; Fiscal Year: 2010
    ..This study will thus provide practical solutions to problems in drug discovery and development with marine natural products. ..
    John Wingard; Fiscal Year: 2001
    ..This information is essential to subsequent planning and implementation of relevant, well-aimed interventions to minimize psychosocial disruption and enhance growth in future BMT recipients and their loved ones. ..
    Jean Rivier; Fiscal Year: 2005
    ..Such molecules are not presently available to academic researchers. As in the past twenty years, collaborations with academic colleagues will be initiated, to maximize the impact of this research. ..