amantadine

Summary

Summary: An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Top Publications

  1. ncbi Placebo-controlled trial of amantadine for severe traumatic brain injury
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute, Edison, NJ, USA
    N Engl J Med 366:819-26. 2012
  2. pmc Efficacy of combined therapy with amantadine, oseltamivir, and ribavirin in vivo against susceptible and amantadine-resistant influenza A viruses
    Jack T Nguyen
    Adamas Pharmaceuticals, Inc, Emeryville, California, United States of America
    PLoS ONE 7:e31006. 2012
  3. pmc Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers
    Sarah D Cady
    Department of Chemistry, Iowa State University, Ames, Iowa 50011 2, USA
    Nature 463:689-92. 2010
  4. ncbi Freezing of gait in patients with advanced Parkinson's disease
    N Giladi
    Department of Neurology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel
    J Neural Transm 108:53-61. 2001
  5. ncbi Synergistic antidyskinetic effects of topiramate and amantadine in animal models of Parkinson's disease
    Christopher Kobylecki
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Mov Disord 26:2354-63. 2011
  6. ncbi Pathological gambling in Parkinson disease is reduced by amantadine
    Astrid Thomas
    Department of Neurology, University G D Annunzio, Chieti and Pescara, Italy
    Ann Neurol 68:400-4. 2010
  7. pmc Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel
    Xianghong Jing
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Proc Natl Acad Sci U S A 105:10967-72. 2008
  8. ncbi Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China
    Guimei He
    Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, People s Republic of China
    Antiviral Res 77:72-6. 2008
  9. pmc Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus
    Victoria Balannik
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208 3500, USA
    Biochemistry 48:11872-82. 2009
  10. ncbi Randomized, double-blind, placebo-controlled study of peginterferon alfa-2a (40KD) plus ribavirin with or without amantadine in treatment-naïve patients with chronic hepatitis C genotype 1 infection
    Peter Ferenci
    Department of Internal Medicine IV, Medical University, Vienna, Austria
    J Hepatol 44:275-82. 2006

Detail Information

Publications280 found, 100 shown here

  1. ncbi Placebo-controlled trial of amantadine for severe traumatic brain injury
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute, Edison, NJ, USA
    N Engl J Med 366:819-26. 2012
    b>Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders of consciousness after traumatic brain injury...
  2. pmc Efficacy of combined therapy with amantadine, oseltamivir, and ribavirin in vivo against susceptible and amantadine-resistant influenza A viruses
    Jack T Nguyen
    Adamas Pharmaceuticals, Inc, Emeryville, California, United States of America
    PLoS ONE 7:e31006. 2012
    ..We describe a triple combination antiviral drug (TCAD) regimen composed of amantadine, oseltamivir, and ribavirin that is highly efficacious at reducing mortality and weight loss in mouse models of ..
  3. pmc Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers
    Sarah D Cady
    Department of Chemistry, Iowa State University, Ames, Iowa 50011 2, USA
    Nature 463:689-92. 2010
    ..M2 protein of influenza A virus is a membrane-spanning tetrameric proton channel targeted by the antiviral drugs amantadine and rimantadine...
  4. ncbi Freezing of gait in patients with advanced Parkinson's disease
    N Giladi
    Department of Neurology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel
    J Neural Transm 108:53-61. 2001
    ..07) while longer duration of amantadine treatment decreased the appearance of FOG (p = 0.09)...
  5. ncbi Synergistic antidyskinetic effects of topiramate and amantadine in animal models of Parkinson's disease
    Christopher Kobylecki
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Mov Disord 26:2354-63. 2011
    L-Dopa-induced dyskinesia in patients with Parkinson's disease can be alleviated by amantadine, an antagonist at N-methyl-D-aspartate glutamate receptors...
  6. ncbi Pathological gambling in Parkinson disease is reduced by amantadine
    Astrid Thomas
    Department of Neurology, University G D Annunzio, Chieti and Pescara, Italy
    Ann Neurol 68:400-4. 2010
    To investigate the possible efficacy of amantadine in the control of pathological gambling (PG) associated with Parkinson disease (PD), 17 PD patients with PG were randomly selected for a double-blind crossover study with amantadine 200mg/..
  7. pmc Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel
    Xianghong Jing
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Proc Natl Acad Sci U S A 105:10967-72. 2008
    ..ion channels, A/M2 and BM2, respectively, and the A/M2 channel activity is inhibited by the drugs amantadine and its methyl derivative rimantadine...
  8. ncbi Amantadine-resistance among H5N1 avian influenza viruses isolated in Northern China
    Guimei He
    Department of Pathophysiology, College of Veterinary Medicine, China Agricultural University, Beijing 100094, People s Republic of China
    Antiviral Res 77:72-6. 2008
    We tested the amantadine-resistance among avian influenza A (H5N1) viruses isolated from chicken in Hebei Province of Northern China from 2001 to 2005, and investigated the amantadine use in this area...
  9. pmc Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus
    Victoria Balannik
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208 3500, USA
    Biochemistry 48:11872-82. 2009
    The A/M2 proton channel of influenza A virus is a target for the anti-influenza drugs amantadine and rimantadine, whose effectiveness was diminished by the appearance of naturally occurring point mutants in the A/M2 channel pore, among ..
  10. ncbi Randomized, double-blind, placebo-controlled study of peginterferon alfa-2a (40KD) plus ribavirin with or without amantadine in treatment-naïve patients with chronic hepatitis C genotype 1 infection
    Peter Ferenci
    Department of Internal Medicine IV, Medical University, Vienna, Austria
    J Hepatol 44:275-82. 2006
    b>Amantadine may augment virological response rates to interferon-based therapy in chronic hepatitis C patients...
  11. ncbi Intravenous amantadine improves levadopa-induced dyskinesias: an acute double-blind placebo-controlled study
    P Del Dotto
    Department of Neuroscience, Neurology Section, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Mov Disord 16:515-20. 2001
    ..Our objective was to evaluate the acute effect of amantadine, a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, on levodopa-induced dyskinesias, and ..
  12. ncbi Oseltamivir, zanamivir and amantadine in the prevention of influenza: a systematic review
    Rachel J Jackson
    Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, UK
    J Infect 62:14-25. 2011
    To systematically review evidence relating to the clinical efficacy of oseltamivir, zanamivir and amantadine in the prevention of influenza.
  13. ncbi Amantadine attenuates levodopa-induced dyskinesia in mice and rats preventing the accompanying rise in nigral GABA levels
    Simone Bido
    Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, Ferrara, Italy
    J Neurochem 118:1043-55. 2011
    b>Amantadine is the only drug marketed for treating levodopa-induced dyskinesia. However, its impact on basal ganglia circuitry in the dyskinetic brain, particularly on the activity of striatofugal pathways, has not been evaluated...
  14. ncbi Emergence and phylogenetic analysis of amantadine-resistant influenza a subtype H3N2 viruses in Dublin, Ireland, over Six Seasons from 2003/2004 to 2008/2009
    A Salter
    Department of Clinical Microbiology, Trinity College Dublin, Ireland
    Intervirology 54:305-15. 2011
    To determine the prevalence of amantadine-resistant influenza A viruses and perform genetic analysis of isolates collected in Dublin during six seasons (2003/2004 to 2008/2009).
  15. pmc Amantadine for dyskinesias in Parkinson's disease: a randomized controlled trial
    Hideyuki Sawada
    Clinical Research Center, Utano National Hospital, Kyoto City, Japan
    PLoS ONE 5:e15298. 2010
    ..The purpose of the present study was to investigate the efficacy of amantadine in Parkinson's disease patients suffering from dyskinesias.
  16. pmc Triple-combination antiviral drug for pandemic H1N1 influenza virus infection in critically ill patients on mechanical ventilation
    Won Young Kim
    Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul 138 736, Republic of Korea sbh
    Antimicrob Agents Chemother 55:5703-9. 2011
    A recent in vitro study showed that the three compounds of antiviral drugs with different mechanisms of action (amantadine, ribavirin, and oseltamivir) could result in synergistic antiviral activity against influenza virus...
  17. pmc Inhibitory effects on HAV IRES-mediated translation and replication by a combination of amantadine and interferon-alpha
    Lingli Yang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Virol J 7:212. 2010
    Hepatitis A virus (HAV) causes acute hepatitis and sometimes leads to fulminant hepatitis. Amantadine is a tricyclic symmetric amine that inhibits the replication of many DNA and RNA viruses...
  18. ncbi The involvement of a Na⁺- and Cl⁻-dependent transporter in the brain uptake of amantadine and rimantadine
    Sander A A Kooijmans
    Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
    Mol Pharm 9:883-93. 2012
    Despite their structural similarity, the two anti-influenza adamantane compounds amantadine (AMA) and rimantadine (RIM) exhibit strikingly different rates of blood-brain barrier (BBB) transport...
  19. ncbi Emergence of amantadine-resistant avian influenza H5N1 virus in India
    C Tosh
    High Security Animal Disease Laboratory, Indian Veterinary Research Institute, Anand Nagar, Bhopal, India
    Virus Genes 42:10-5. 2011
    ..acid substitution from serine-to-asparagine at position 31 of M2 ion channel protein suggesting emergence of amantadine-resistant mutants not previously reported in HPAI H5N1 outbreaks in India...
  20. ncbi New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma
    Cui Shuangjin
    Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China
    J Pharm Biomed Anal 44:1100-5. 2007
    A novel precolumn derivatization method is described for the quantitative determination of amantadine, rimantadine and memantine in biological samples by HPLC with UV detection...
  21. ncbi Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine
    A E Busch
    Institut fur Physiologie, 72076 Tubingen, Germany
    Mol Pharmacol 54:342-52. 1998
    ..transport of norepinephrine, histamine, dopamine, serotonin, and the antiparkinsonian drugs memantine and amantadine was demonstrated by tracer influx, tracer efflux, electrical measurements, or a combination...
  22. ncbi Does amantadine have favourable effects on fatigue in Persian patients suffering from multiple sclerosis?
    Fereshteh Ashtari
    Neurology Department, Isfahan Neurosciences Research Centre, Isfahan University of Medical Sciences, Iran
    Neurol Neurochir Pol 43:428-32. 2009
    ..b>Amantadine is one of the medications prescribed for fatigue in MS...
  23. ncbi Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs
    H J Otton
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Neuropharmacology 60:388-96. 2011
    Clinically, amantadine and memantine are drugs whose therapeutic utility is linked to their ability to block N-methyl-D-aspartate receptors (NMDARs) in a voltage-dependent manner...
  24. pmc Oseltamivir- and amantadine-resistant influenza viruses A (H1N1)
    Peter K C Cheng
    Centre for Health Protection, Hong Kong Special Administrative Region, People s Republic of China
    Emerg Infect Dis 15:966-8. 2009
    Surveillance of amantadine and oseltamivir resistance among influenza viruses was begun in Hong Kong in 2006...
  25. ncbi Why amantadine loses its function in influenza m2 mutants: MD simulations
    Chittima Laohpongspaisan
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand
    J Chem Inf Model 49:847-52. 2009
    ..M2 mutants, A30T, S31N, and L26I, were carried out to investigate the inhibition of M2 activity using amantadine (AMT). The closed and open channel conformations were examined via non- and triply protonated H37...
  26. ncbi Repeated co-treatment with imipramine and amantadine induces hippocampal brain-derived neurotrophic factor gene expression in rats
    Z Rogoz
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 58:219-34. 2007
    ..earlier papers we described synergistic, antidepressant-like effects of a combination of imipramine (IMI) and amantadine (AMA) in the forced swimming test in rats, an animal model of depression...
  27. ncbi Detection of amantadine-resistant variants among avian influenza viruses isolated in North America and Asia
    Natalia A Ilyushina
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Virology 341:102-6. 2005
    Here, we report the diversity of amantadine-resistant mutants among avian influenza A viruses with pandemic potential (H5, H6, H7, and H9 hemagglutinin subtypes)...
  28. ncbi Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD
    F Bibbiani
    ETB, NINDS, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Neurol 196:422-9. 2005
    ..of the selective AMPA receptor antagonist GYKI-47261 and the selective NMDA receptor antagonists, MK-801 and amantadine, to mitigate these syndromes in rodent and primate models of Parkinson's disease...
  29. ncbi Contribution of H7 haemagglutinin to amantadine resistance and infectivity of influenza virus
    Natalia A Ilyushina
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Gen Virol 88:1266-74. 2007
    In the present study we determined the antiviral effect of amantadine against influenza A/Netherlands/219/03 (H7N7) virus in cell culture and in a mouse model...
  30. ncbi Long-term antidyskinetic efficacy of amantadine in Parkinson's disease
    Elisabeth Wolf
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Mov Disord 25:1357-63. 2010
    Several randomized placebo-controlled trials have consistently shown antidyskinetic effects of amantadine in levodopa treated patients with advanced Parkinson's disease (PD)...
  31. ncbi Amantadine use associated with impulse control disorders in Parkinson disease in cross-sectional study
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Neurol 68:963-8. 2010
    A recent controlled clinical trial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD)...
  32. pmc Structural basis for the function and inhibition of an influenza virus proton channel
    Amanda L Stouffer
    Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 451:596-9. 2008
    ..M2 is the target of the anti-influenza drugs amantadine and rimantadine; recently, resistance to these drugs in humans, birds and pigs has reached more than 90% (ref...
  33. ncbi A randomized trial of amantadine in Huntington disease
    Padraig O'Suilleabhain
    Department of Neurology, University of Texas Southwestern Medical School, Dallas 75390, USA
    Arch Neurol 60:996-8. 2003
    Huntington chorea, like levodopa-induced dyskinesias, may be responsive to amantadine hydrochloride treatment.
  34. ncbi High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza
    Kyoko Shiraishi
    Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Infect Dis 188:57-61. 2003
    Clinical samples from 15 amantadine-treated children were collected serially-before, during, and/or after treatment-and were studied to determine the actual prevalence, timing, and clinical implications of M2 mutational events...
  35. pmc Modeling amantadine treatment of influenza A virus in vitro
    Catherine A A Beauchemin
    Department of Physics, Ryerson University, 350 Victoria St, Toronto, ON M5B2K3, Canada
    J Theor Biol 254:439-51. 2008
    ..MDCK cells in vitro inside a hollow-fiber (HF) system, which was used to continuously deliver the drug amantadine. The HF system captures the dynamics of an influenza infection, and is a controlled environment for producing ..
  36. ncbi How amantadine and rimantadine inhibit proton transport in the M2 protein channel
    Pathumwadee Intharathep
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand
    J Mol Graph Model 27:342-8. 2008
    ..In the presence of inhibitor, water density in the channel was considerably better reduced by rimantadine than amantadine, agreed well with the experimental IC(50) values...
  37. pmc Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block
    Franck C Chatelain
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 4:e7496. 2009
    ....
  38. pmc Epidemiologic study of influenza infection in Okinawa, Japan, from 2001 to 2007: changing patterns of seasonality and prevalence of amantadine-resistant influenza A virus
    Yasushi Suzuki
    Department of Public Health, Niigata University, Graduate School of Medical and Dental Sciences, 1 757, Asahimachi Dori, Niigata City, Niigata Prefecture 951 8510, Japan
    J Clin Microbiol 47:623-9. 2009
    To clarify seasonal influenza patterns and the prevalence of amantadine-resistant influenza A viruses in Okinawa, located at the southern extremity of Japan in a subtropical climate, we conducted a laboratory-based study of influenza ..
  39. ncbi The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine
    Stephen D C Griffin
    School of Biochemistry and Molecular Biology, University of Leeds, Division of Microbiology Old Medical School, Thoresby Place, Leeds LS2 9JT, UK
    FEBS Lett 535:34-8. 2003
    ..This activity is abrogated by Amantadine, a compound that inhibits ion channels of influenza [Hay, A.J. et al. (1985) EMBO J. 4, 3021-3024; Duff, K.C...
  40. ncbi How does influenza virus a escape from amantadine?
    Guangrong Qin
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    J Phys Chem B 114:8487-93. 2010
    Antiflu drugs such as amantadine (AMT) were reported to be insensitive to influenza A virus gradually after their marketing...
  41. ncbi Amantadine therapy in renal transplant patients with hepatitis C virus infection
    Nassim Kamar
    Department of Nephrology, Dialysis and Transplantation, CHU Toulouse Rangueil, TSA 50032, 31059 Toulouse Cedex 9, France
    J Clin Virol 30:110-4. 2004
    To date, there is no safe and efficient treatment of hepatitis C virus (HCV) infection after renal transplantation. Recently, there were encouraging reports after using amantadine in HCV-positive immunocompetent patients.
  42. ncbi Safety of perioperative treatment with intravenous amantadine in patients with Parkinson disease
    Aeyal Raz
    Departments of Anesthesiology, Neurology, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel and Department of Anesthesiology, University of Wisconsin, Madison, WI
    Clin Neuropharmacol 36:166-9. 2013
    ..The aim of the study was to investigate the safety and efficacy of intravenous administration of amantadine on parkinsonian features during and after surgery.
  43. ncbi Amantadine- and oseltamivir-resistant variants of influenza A viruses in Thailand
    Gui Rong Bai
    Section of Viral Infections, Thailand Japan Research Collaboration Center on Emerging and Re emerging Infections, Nonthaburi 11000, Thailand
    Biochem Biophys Res Commun 390:897-901. 2009
    b>Amantadine and oseltamivir are used to treat influenza A virus infections; however, resistance to these drugs has been widely reported throughout the world...
  44. pmc Large-scale sequence analysis of M gene of influenza A viruses from different species: mechanisms for emergence and spread of amantadine resistance
    Yuki Furuse
    Department of Virology, Tohoku University Graduate School of Medicine 2 1 Seiryou mach, Aoba ku, Sendai, 980 8575, Japan
    Antimicrob Agents Chemother 53:4457-63. 2009
    Influenza A virus infects many species, and amantadine is used as an antiviral agent...
  45. ncbi Plasma amantadine concentrations in patients with Parkinson's disease
    N Nishikawa
    Department of Medicine Neurology, Ehime University Graduate School of Medicine, Shitsukawa Tohon, Ehime 791 0295, Japan
    Parkinsonism Relat Disord 15:351-3. 2009
    We determined plasma amantadine concentrations in patients with Parkinson's disease (PD) in daily clinical practice and investigated the relationship between plasma concentration and adverse reactions to clarify the safe therapeutic range...
  46. ncbi Reversible amantadine-induced corneal edema in an adolescent
    Bradley Hughes
    Cornea Service, Jones Eye Institute, and Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Cornea 23:823-4. 2004
    To document reversible corneal edema caused by amantadine in a pediatric patient.
  47. ncbi Amantadine treatment following traumatic brain injury in children
    Sharon E Williams
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Brain Inj 21:885-9. 2007
    The focus of this paper is to review the current literature on the use of amantadine in children who have sustained a head injury.
  48. ncbi Emergence and transmission of amantadine-resistant influenza A in a nursing home
    Margo Schilling
    University of Iowa, Iowa City, USA
    J Am Geriatr Soc 52:2069-73. 2004
    To prospectively detect amantadine-resistant influenza when amantadine was used for influenza A outbreak control.
  49. ncbi Amantadine in pediatric patients with traumatic brain injury: a retrospective, case-controlled study
    Liza B Green
    Department of Physical Medicine and Rehabilitation, University of Michigan Health Systems, Ann Arbor, Michigan 48103, USA
    Am J Phys Med Rehabil 83:893-7. 2004
    To determine if amantadine use in pediatric patients with traumatic brain injury is well tolerated and to attempt to assess its effectiveness.
  50. ncbi Regulation of amantadine hydrochloride binding with IIA subdomain of human serum albumin by fatty acid chains
    Feng Yang
    State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China Guangxi Normal University, Guilin, Guangxi, China
    J Pharm Sci 102:84-92. 2013
    ..For our experiments, we tested amantadine hydrochloride, a cationic drug with antiviral and antiparkinsonian effects...
  51. ncbi N-Methyl-D-Aspartate antagonists in levodopa induced dyskinesia: a meta-analysis
    Behzad Elahi
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Can J Neurol Sci 39:465-72. 2012
    ..In this study, we compared the efficacy of NMDA receptor antagonists versus placebo in the treatment of LID in PD through a meta-analysis of controlled trials...
  52. pmc Where does amantadine bind to the influenza virus M2 proton channel?
    Dima Kozakov
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    Trends Biochem Sci 35:471-5. 2010
    ..By considering all available models, we propose the primary drug binding site is inside the pore, but that exterior binding occurs under appropriate conditions...
  53. ncbi Movement disorder in ataxia-telangiectasia: treatment with amantadine sulfate
    Andreea Nissenkorn
    The National A T Clinic, Edmond and Lilly Safra Children s Hospital, Sheba Medical Center, Ramat Gan, Israel
    J Child Neurol 28:155-60. 2013
    ..2 ± 3.9 years) for 8 weeks with the dopaminergic and anti-N-methyl-d-aspartate (NMDA) agent amantadine sulfate 6.3 ± 0.87 mg/kg/d...
  54. pmc Triple combination antiviral drug (TCAD) composed of amantadine, oseltamivir, and ribavirin impedes the selection of drug-resistant influenza A virus
    Justin D Hoopes
    Adamas Pharmaceuticals, Inc, Emeryville, California, United States of America
    PLoS ONE 6:e29778. 2011
    ..A triple combination antiviral drug (TCAD) regimen comprised of amantadine, oseltamivir, and ribavirin has been shown to have synergistic and broad spectrum activity against influenza A ..
  55. ncbi Amantadine for the treatment of refractory absence seizures in children
    M Scott Perry
    Comprehensive Epilepsy Program, Cook Children s Medical Center, Fort Worth, Texas 76109, USA
    Pediatr Neurol 46:243-5. 2012
    b>Amantadine has demonstrated efficacy in small series for absence and myoclonic type seizures. We examined the efficacy of amantadine for treating refractory absence seizures in a cohort of pediatric patients...
  56. ncbi Amantadine improves gait in PD patients with STN stimulation
    Hiu Fai Chan
    Movement Disorders Center, Division of Neurology, TWH, University of Toronto, UHN, Toronto, Ontario, Canada
    Parkinsonism Relat Disord 19:316-9. 2013
    ..We anecdotally observed that oral administration of amantadine was very effective in treating both residual and stimulation-induced axial symptoms after bilateral STN-DBS in ..
  57. ncbi Delirium with manic and psychotic features associated with amantadine
    Adriana D Neagoe
    Harvard Medical School, Boston MA 02302, USA Electronic address
    Gen Hosp Psychiatry 35:680.e7-8. 2013
    While clinicians are familiar with psychosis as a complication in the long-term treatment with amantadine, rapid psychiatric complications are of much less concern...
  58. ncbi Dropped head associated with amantadine in Parkinson disease
    Hiroshi Kataoka
    Department of Neurology, Nara Medical University, Kashihara, Nara, Japan
    Clin Neuropharmacol 34:48-9. 2011
    The antiviral agent amantadine has been used to manage Parkinson's disease or levodopa-induced dyskinesias for nearly 5 decades...
  59. ncbi Effects of amantadine treatment on in vitro production of interleukin-2 in de-novo patients with idiopathic Parkinson's disease
    K P Wandinger
    Institute of Immunology and Transfusion Medicine, University of Lübeck School of Medicine, Germany
    J Neuroimmunol 98:214-20. 1999
    ..of de-novo patients with idiopathic Parkinson's disease (PD) at the time of first diagnosis and after oral amantadine treatment...
  60. ncbi Amantadine blocks channel activity of the transmembrane segment of the NB protein from influenza B
    W B Fischer
    Department of Biochemistry, University of Oxford, UK
    Eur Biophys J 30:416-20. 2001
    ..Channels formed by the protein can be blocked by amantadine. We have synthesized the putative transmembrane segment of NB (IRG S20 IIITICVSL I30 VILIVFGCI A40 KIFI (NB, Lee)..
  61. pmc Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GDNF in astroglia [corrected]
    Bernardino Ossola
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
    Neuropharmacology 61:574-82. 2011
    b>Amantadine is commonly given to alleviate L-DOPA-induced dyskinesia of Parkinson's disease (PD) patients. Animal and human evidence showed that amantadine may also exert neuroprotection in several neurological disorders...
  62. ncbi Amantadine triple therapy for non-responder hepatitis C patients. Clues for controversies (ANRS HC 03 BITRI)
    Marianne Maynard
    Department of Hepato Gastroenterology, Hotel Dieu, 1 Place de l Hopital, 69288 Lyon Cedex 02, France
    J Hepatol 44:484-90. 2006
    To determine whether addition of amantadine to pegylated interferon/ribavirin improved response rates among chronic hepatitis C patients, non-responders to interferon/ribavirin and study the dynamic of response.
  63. ncbi Rapid simultaneous determination of paracetamol, amantadine hydrochloride, caffeine and chlorpheniramine maleate in human plasma by liquid chromatography/tandem mass spectrometry
    Shudan Feng
    Key Laboratory of Drug Quality Control and Pharmacovigilance China Pharmaceutical University, Ministry of Education, Nanjing, The People s Republic of China
    Arzneimittelforschung 59:86-95. 2009
    ..HPLC-ESI-MS/MS) was first developed and validated to simultaneously determine paracetamol (PAR, CAS 103-90-2), amantadine hydrochloride (ATH, CAS 665-66-7), caffeine (CAF, CAS 58-08-2) and chlorpheniramine maleate (CPM, CAS 113-92-8) ..
  64. ncbi Successful protection by amantadine hydrochloride against lethal encephalitis caused by a highly neurovirulent recombinant influenza A virus in mice
    Isamu Mori
    Department of Microbiology, Fukui Medical University School of Medicine, Fukui, Japan
    Virology 303:287-96. 2002
    ..The intraperitoneal administration of amantadine inhibited the viral growth in the brain and saved mice from the lethal encephalitis...
  65. ncbi Simultaneous determination of amantadine and rimantadine by HPLC in rat plasma with pre-column derivatization and fluorescence detection for pharmacokinetic studies
    Yasuhiko Higashi
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho 3, Kanagawa machi, Kanazawa 920 1181, Japan
    Biomed Chromatogr 19:655-62. 2005
    We investigated simultaneous high-performance liquid chromatographic (HPLC) determination of amantadine hydrochloride (AMA) and rimantadine hydrochloride (RIM) levels in rat plasma after fluorescent derivatization with o-phthalaldehyde ..
  66. pmc A randomized controlled trial of double versus triple therapy with amantadine for genotype 1 chronic hepatitis C in Latino patients
    Jorge Mendez-Navarro
    Departamento de Gastroenterologia, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS, Av Cuauhtemoc 330, Col Doctores, 06725, Mexico, DF, Mexico
    Dig Dis Sci 55:2629-35. 2010
    ..b>Amantadine has been proposed to improve response rates in addition to standard therapy with peginterferon alpha and ..
  67. ncbi Repeated co-treatment with fluoxetine and amantadine induces brain-derived neurotrophic factor gene expression in rats
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 60:817-26. 2008
    ..In the present study, we investigated the influence of repeated treatment with fluoxetine (FLU, 5 or 10 mg/kg) and amantadine (AMA, 10 mg/kg), given separately or jointly (twice daily for 14 day), at the mRNA level (the Northern blot) in ..
  68. ncbi Amantadine, oseltamivir and zanamivir for the prophylaxis of influenza (including a review of existing guidance no. 67): a systematic review and economic evaluation
    P Tappenden
    University of Sheffield, School of Health and Related Research, UK
    Health Technol Assess 13:iii, ix-xii, 1-246. 2009
    To evaluate the clinical effectiveness and incremental cost-effectiveness of amantadine, oseltamivir and zanamivir for seasonal and post-exposure prophylaxis of influenza.
  69. ncbi Simultaneous determination of memantine and amantadine in human plasma as fluorescein derivatives by micellar electrokinetic chromatography with laser-induced fluorescence detection and its clinical application
    Hsin Hua Yeh
    School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
    Electrophoresis 31:1903-11. 2010
    ..detection was developed for the simultaneous determination of memantine, an anti-Alzheimer's disease agent, and amantadine, an anti-Parkinson's disease drug, in human plasma...
  70. pmc Genetic makeup of amantadine-resistant and oseltamivir-resistant human influenza A/H1N1 viruses
    Hassan Zaraket
    Division of Public Health, Department of Infectious Disease Control and International Medicine, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Clin Microbiol 48:1085-92. 2010
    ..Seasonal influenza A/H1N1 viruses, including antiviral-susceptible viruses, amantadine-resistant viruses, and oseltamivir-resistant viruses, obtained from several areas in Japan during the 2007-2008 ..
  71. ncbi Effect of amantadine and imipramine on immunological parameters of rats subjected to a forced swimming test
    Marta Kubera
    Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Int J Neuropsychopharmacol 9:297-305. 2006
    ..In our previous studies we described synergistic, antidepressant-like effects of a combination of amantadine (10 mg/kg) and imipramine (5 mg/kg) - drugs otherwise ineffective when given separately in such doses - in the ..
  72. ncbi Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15
    Seong Soo Joo
    Department of Immunology, College of Pharmacy, Chung Ang University, 221 Huksuk Dong, Dongjak Ku, Seoul 156 756, Korea
    Arch Pharm Res 29:405-11. 2006
    ..b>Amantadine is an antiviral agent, which is utilized primarily in the treatment of influenza, but also, occasionally in the ..
  73. ncbi Assessment of treatment algorithms including amantadine, metformin, and zonisamide for the prevention of weight gain with olanzapine: a randomized controlled open-label study
    Vicki Poole Hoffmann
    Neuroscience Division, Eli Lilly and Company, Indianapolis, IN, USA
    J Clin Psychiatry 73:216-23. 2012
    ..2006 and September 2008 in a community setting, was designed to determine if weight gain during olanzapine treatment can be prevented or mitigated with adjunctive treatment algorithms that include amantadine, metformin, and zonisamide.
  74. ncbi Efficacy of amantadine on quality of life in patients with chronic hepatitis C treated with interferon-alpha and ribavirin: results from a randomized, placebo-controlled, double-blind trial
    Bernd Kronenberger
    Department of Medicine I, Johann Wolfgang Goethe University Medical Center, Frankfurt M, Germany
    Eur J Gastroenterol Hepatol 19:639-46. 2007
    The aim of this study was to investigate whether amantadine reduces deterioration of quality of life in patients with chronic hepatitis C during and after treatment with interferon-alpha (IFN-alpha) and ribavirin.
  75. ncbi Amantadine increases L-DOPA-derived extracellular dopamine in the striatum of 6-hydroxydopamine-lesioned rats
    Akira Arai
    Department of Neurological Science, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8216, Japan
    Brain Res 972:229-34. 2003
    We investigated the effect of amantadine on L-DOPA-derived extracellular dopamine (DA) levels and aromatic L-amino acid decarboxylase (AADC) activity in the striatum of rats with nigrostriatal dopaminergic denervation by 6-hydroxydopamine ..
  76. doi Emergence and phylogenetic relationships of amantadine-resistant human H3N2 influenza A viruses in Germany in the season 2005/2006
    Michaela Schmidtke
    Int J Antimicrob Agents 32:192-5. 2008
  77. ncbi Amantadine in a multimodal analgesic regimen for alleviation of refractory osteoarthritis pain in dogs
    B D X Lascelles
    Comparative Pain and Orthopedic Research Laboratories, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Vet Intern Med 22:53-9. 2008
    ..Nonsteroidal anti-inflammatory drugs (NSAIDs) do not always provide sufficient pain relief in dogs with osteoarthritis (OA)...
  78. ncbi Amantadine versus methylphenidate in children and adolescents with attention deficit/hyperactivity disorder: a randomized, double-blind trial
    Mohammad Reza Mohammadi
    Psychiatric Research Centre, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Hum Psychopharmacol 25:560-5. 2010
    The aim of the present study was to further evaluate, under double blind and controlled conditions, the efficacy of amantadine for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents as compared to methylphenidate.
  79. ncbi Genomic events contributing to the high prevalence of amantadine-resistant influenza A/H3N2
    Hassan Zaraket
    Division of Public Health, Department of Infectious Disease Control and International Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Antivir Ther 15:307-19. 2010
    The prevalence of amantadine-resistant influenza A/H3N2 viruses (belonging to the N-lineage), possessing an S31N mutation in the M2 protein and S193F and D225N substitutions in their HA1 subunit, has significantly increased worldwide ..
  80. ncbi Intravenous amantadine sulphate application improves the performance of complex but not simple motor tasks in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany
    Neurosci Lett 339:25-8. 2003
    Intravenous application of amantadine sulphate induces a rapid improvement of motor symptoms in Parkinson's disease (PD), but there are no trials on the efficacy of this compound on bradykinesia, rigidity and tremor in detail in ..
  81. ncbi Neurobehavioral effects of amantadine after pediatric traumatic brain injury: a preliminary report
    Sue R Beers
    Traumatic Brain Injury Program, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    J Head Trauma Rehabil 20:450-63. 2005
    To investigate the safety and efficacy of a dopamine agonist, amantadine hydrochloride (AMH), in the treatment of neurobehavioral sequelae of pediatric TBI.
  82. ncbi A randomized trial of pegylated-interferon-alpha2a plus ribavirin with or without amantadine in the re-treatment of patients with chronic hepatitis C not responding to standard interferon and ribavirin
    A Ciancio
    Dipartimento di Gastroenterologia, Ospedale Molinette, Torino, Italy
    Aliment Pharmacol Ther 24:1079-86. 2006
    ..There is yet no established treatment for chronic hepatitis C patients non-responder to standard interferon and ribavirin...
  83. ncbi Fluoxetine differentially suppresses sucrose solution consumption in free-fed and food-deprived rats--reversal by amantadine
    Mark A Prendergast
    Department of Psychology, University of Nebraska at Omaha, NE 68182, USA
    Med Sci Monit 8:BR385-90. 2002
    ..It is unclear, however, if fluoxetine-induced consummatory suppression may be influenced by factors such as dietary status and if appetite suppressant effects of fluoxetine may be pharmacologically attenuated...
  84. ncbi Quantitative determination of amantadine in human plasma by liquid chromatography-mass spectrometry and the application in a bioequivalence study
    Ping Wang
    College of Chemistry and Chemical Engineering, Research Center of Modernization of Chinese Medicines, Central South University, Changsha 410083, PR China
    J Pharm Biomed Anal 43:1519-25. 2007
    ..ionization mass spectrometry (LC-ESI-MS) method is developed and validated for rapid determination of amantadine in human plasma. Desloratadine was used as the internal standard (I.S.). Human plasma (0...
  85. ncbi Amantadine to improve neurorecovery in traumatic brain injury-associated diffuse axonal injury: a pilot double-blind randomized trial
    Jay M Meythaler
    Department of Physical Medicine and Rehabilitation, Spain Rehabilitation Center R157, School of Medicine, University of Alabama at Birmingham, 619 6th Avenue, Birmingham, AL 35249 7330, USA
    J Head Trauma Rehabil 17:300-13. 2002
    ..Because of its affect on both dopamine and N-methyl-D-aspartate (NMDA) channels, amantadine has been the subject of considerable interest and clinical use in acute TBI.
  86. ncbi A screening trial of amantadine as a medication for cocaine dependence
    Steve Shoptaw
    Friends Research Institute, Inc, 11075 Santa Monica Blvd, Suite 350, Los Angeles, CA 90025, USA
    Drug Alcohol Depend 66:217-24. 2002
    This screening trial evaluated whether amantadine hydrochloride (100 mg bid) demonstrated sufficient clinical efficacy compared to placebo to recommend development as a pharmacotherapy for cocaine dependence...
  87. ncbi Hepatitis C Virus p7 membrane protein quasispecies variability in chronically infected patients treated with interferon and ribavirin, with or without amantadine
    S Castelain
    Virologie, CHU Hopital Sud, Amiens, France
    J Med Virol 79:144-54. 2007
    ..C virus (HCV) genotype 1 chronically infected patients treated with interferon and ribavirin, with or without amantadine. The viral load decreased more markedly in the group treated by tritherapy including amantadine, but the ..
  88. ncbi Effects of amantadine on tardive dyskinesia: a randomized, double-blind, placebo-controlled study
    Sofia Pappa
    Department of Psychiatry, University Hospital of Ioannina, Ioannina, Greece
    Clin Neuropharmacol 33:271-5. 2010
    The objective of the study was to demonstrate whether the N-methyl-D-aspartate antagonist, amantadine, can safely ameliorate tardive dyskinesia (TD) without deteriorating the mental state of the patients.
  89. ncbi A randomized controlled trial of pegylated interferon alpha-2a (40 KD) or interferon alpha-2a plus ribavirin and amantadine vs interferon alpha-2a and ribavirin in treatment-naïve patients with chronic hepatitis C
    A Mangia
    Division of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, 71013 San Giovanni Rotondo, Italy
    J Viral Hepat 12:292-9. 2005
    We determined whether triple therapy comprising amantadine (AMA), ribavirin (RBV) and either peginterferon (PEG-IFN) alpha-2a or conventional IFN alpha-2a would improve sustained virological response (SVR) rates over dual therapy with IFN ..
  90. ncbi A double-blind, cross-over comparison of the effects of amantadine or placebo on visuomotor and cognitive function in medicated schizophrenia patients
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Hadera, Israel
    Int Clin Psychopharmacol 20:319-26. 2005
    ..The effect of amantadine on neuropsychological function in medicated schizophrenia patients was investigated...
  91. pmc Frequency of amantadine-resistant influenza A viruses during two seasons featuring cocirculation of H1N1 and H3N2
    Reiko Saito
    Department of Public Health, Graduate School of Medical and Dental Sciences, Niigata City, Niigata Prefecture 951 8510, Japan
    J Clin Microbiol 41:2164-5. 2003
    ..during which H1N1 and H3N2 cocirculated, resistance was more frequent in H3N2 strains than in H1N1 strains after amantadine treatment...
  92. ncbi Neuraminidase inhibitors in patients with underlying airways disease
    John C Williamson
    Department of Pharmacy, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157, USA
    Am J Respir Med 1:85-90. 2002
    ..Unlike NAIs, the older therapeutic options amantadine and rimantadine may cause significant central nervous system adverse effects...
  93. pmc Rapid and specific detection of amantadine-resistant influenza A viruses with a Ser31Asn mutation by the cycling probe method
    Yasushi Suzuki
    Department of Public Health, Niigata University, Graduate School of Medical and Dental Sciences, 1 757, Asahimachi Dori, Niigata City, Niigata Prefecture 951 8510, Japan
    J Clin Microbiol 48:57-63. 2010
    b>Amantadine is one of the antiviral agents used to treat influenza A virus infections, but resistant strains have widely emerged worldwide...
  94. ncbi Amantadine sulfate reduces experimental sensitization and pain in chronic back pain patients
    Dieter Kleinböhl
    Laboratory for Clinical Psychophysiology, Otto Selz Institute, University of Mannheim
    Anesth Analg 102:840-7. 2006
    ..musculoskeletal pain can be reduced by adjuvant treatment with a N-methyl-d-aspartate receptor antagonist, amantadine sulfate, and whether a reduction in sensitization might be accompanied by a concurrent improvement in clinical ..
  95. ncbi Amantadine treatment of hemispatial neglect: a double-blind, placebo-controlled study
    Laurel J Buxbaum
    Moss Rehabilitation Research Institute, Philadelphia, Pennsylvania 19141, USA
    Am J Phys Med Rehabil 86:527-37. 2007
    ..neglect syndrome (hypokinesia, decreased arousal) to aspects of Parkinsonian syndromes, and the success of amantadine in treating disorders of attention, prompted a placebo-controlled, double-blind trial of amantadine, an ..
  96. ncbi Frequency of amantadine-resistant influenza A virus isolated from 2001-02 to 2004-05 in Nara Prefecture
    Yoshiteru Kitahori
    Virology and Bacteriology Division, Nara Prefectural Institute for Hygiene and Environment, Nara 630 8131, Japan
    Jpn J Infect Dis 59:197-9. 2006
    We investigated the frequency of amantadine-resistant influenza A viruses in Nara Prefecture during four epidemic seasons from 2001-02 to 2004-05. Point mutations within the M2 gene were identified using RT-PCR and DNA sequencing analysis...
  97. ncbi Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001
    Michaela Schmidtke
    Institute of Virology and Antiviral Therapy, Medical Centre of the Friedrich Schiller University Jena, Jena, Germany
    Intervirology 49:286-93. 2006
    This study was designed to gain insight into amantadine susceptibility of porcine influenza A viruses isolated in Germany between 1981 and 2001...
  98. ncbi Synergistic effect of imipramine and amantadine in the forced swimming test in rats. Behavioral and pharmacokinetic studies
    Zofia Rogóż
    Department of Pharmacology, Institute of Pharmacology, Polsih Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pol J Pharmacol 56:179-85. 2004
    ..of a tricyclic antidepressant drug, imipramine (IMI) with the uncompetitive antagonist of NMDA receptor, amantadine (AMA), produced stronger "antidepressant" effect in the forced swimming test (Porsolt's test) than the treatment ..
  99. ncbi An off-seasonal amantadine-resistant H3N2 influenza outbreak in Japan
    Reiko Saito
    Department of Public Health, Graduate School of Medical and Dental Sciences, Niigata University, Japan
    Tohoku J Exp Med 210:21-7. 2006
    An off-season community influenza outbreak with high prevalence of amantadine-resistant influenza A/H3N2 occurred during September-October 2005 in Nagasaki Prefecture, Japan, prior to standard influenza circulation...
  100. ncbi High prevalence of amantadine-resistance influenza a (H3N2) in six prefectures, Japan, in the 2005-2006 season
    Reiko Saito
    Department of Public Health, Niigata University, Graduate School of Medical and Dental Science, Niigata, Japan
    J Med Virol 79:1569-76. 2007
    Substantial increase in amantadine-resistant influenza A (H3N2) was reported in Asia and North America in 2005...
  101. ncbi IV amantadine improves chorea in Huntington's disease: an acute randomized, controlled study
    J M Heckmann
    Neurology 63:597-8; author reply 597-8. 2004

Research Grants62

  1. Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Childhood Depression
    Mary A Fristad; Fiscal Year: 2013
    ....
  2. Reducing Dyskinesia in Parkinson Disease with Omega-3 Fatty Acids
    KATHRYN ANNE CHUNG; Fiscal Year: 2012
    ..There are surprisingly few treatments for LID, including amantadine and deep brain stimulation...
  3. Structure of M2 proton channel from influenza A Virus
    William F Degrado; Fiscal Year: 2013
    ..by applicant): The M2 proton channel protein of the influenza A virus is the target of the anti-influenza drug, amantadine. M2 contains a single transmembrane domain that forms the homo-tetrameric pore of this channel...
  4. Adjunct Aripiprazole for Symptomatic Hyperprolactinemia in Female Schizophrenia
    Deanna L Kelly; Fiscal Year: 2013
    ..is little evidence to guide treatment in this important area however dopamine agonists such as bromocriptine or amantadine may exacerbate symptoms, have lacking efficacy data and are associated with side effects...
  5. Identification of novel influenza antivirals
    GREGORY WILLIAM HENKEL; Fiscal Year: 2012
    ..However, only one class of drug (neuraminidase inhibitors) is currently available;amantadine-resistance has become so widespread the amantadanes have become ineffective...
  6. Development of drugs that target the M2 proton channel from the influenza A Virus
    William F Degrado; Fiscal Year: 2012
    ..there are two different classes of approved anti-influenza drugs, which target different viral proteins: amantadine targets a protein called the M2 proton channel, while Tamiflu (oseltamivir) targets neuraminidase...
  7. Novel anti-viral agents to treat influenza
    Dipanwita Basu; Fiscal Year: 2013
    ..Likewise, currently available anti-influenza drugs such as amantadine and oseltamivir are only partially effective in treatment prophylaxis, and also suffer from problems of drug ..
  8. Solid-state NMR of the influenza M2 protein in lipid bilayers
    Mei Hong; Fiscal Year: 2013
    ..Inhibition of the H+ channel activity by the amantadine class of antiviral drugs has been made ineffective by mutations in the M2 transmembrane domain...
  9. Traumatic Brain Injury Clinical Trials Network
    Thomas Novack; Fiscal Year: 2010
    ..One medication, Amantadine, has been the subject of considerable interest and clinical use...
  10. Evaluating BMY-14802 as an anti-dyskinesia treatment in the 6-OHDA rat model of P
    MELANIE PAQUETTE; Fiscal Year: 2009
    ..e., amantadine, dextromethorphan, and buspirone)...
  11. Correlations: Structure-Dynamics-Function in Channels
    Timothy A Cross; Fiscal Year: 2013
    ..Similarly, data from the S31N mutant and in the presence and absence of amantadine will be combined to reach a detailed understanding of how the drug blocks conductance in the wild-type protein ..
  12. OPTIMIZATION OF NOVEL INFLUENZA M2 CHANNEL INHIBITORS
    KEN J MCCORMACK; Fiscal Year: 2013
    ..b>Amantadine-resistance has become so widespread the adamantanes have become all but ineffective...
  13. Amantadine + rTMS as a Neurotherapeutic for Disordered Consciousness after TBI
    Theresa Louise Bender Pape; Fiscal Year: 2013
    ..is to examine the safety and efficacy of repetitive transcranal magnetic stimulation (rTMS) combined with Amantadine (TMS + Amantadine) relative to rTMS Alone and Amantadine Alone for persons in chronic states of SIC...
  14. Structural basis for influenza amantadine-resistance
    James J Chou; Fiscal Year: 2010
    ..b>Amantadine is a licensed anti-influenza A drug that functions by inhibiting the pH activation of the M2 channel...
  15. Development of novel broad-spectrum influenza A inhibitors
    KEN J MCCORMACK; Fiscal Year: 2012
    ..b>Amantadine- resistance has become so widespread the amantadanes have become all but ineffective and some flu strains have ..
  16. Peptide drugs against influenza virus
    Robert Garry; Fiscal Year: 2007
    ..The new strains of bird flu appear to be resistant to amantadine and related influenza drugs...
  17. TREATMENT OF CHRONIC HEPATITIS C WITH AMANTADINE HC1
    Jill Smith; Fiscal Year: 1999
    ..of Medicine in which adult patients with hepatitis C who had failed to respond to interferon were treated with amantadine-HC1 for six months...
  18. INFLUENZA B VIRUS AND MATRIX GENE ORF
    DAN DEBORDE; Fiscal Year: 1990
    ..g. type B influenza is resistant to the antiviral activity of amantadine and its derivatives while type A influenza is not...
  19. MECHANISM OF INJURY IN THE GUILLAIN BARRE SYNDROME
    Tony Ho; Fiscal Year: 1999
    ....
  20. Novel VLP vaccines for pandemic influenza virus
    Richard W Compans; Fiscal Year: 2010
    ..These strains are of particular concern because they are resistant to the most cost-effective antiviral drugs, amantadine and rimantadine...
  21. CHINESE PARALYTIC SYNDROME - MECHANISMS AND RELEVANCE
    GUY MC KHANN; Fiscal Year: 2001
    ..abstract_text> ..
  22. Mapping the M2 Proton Channel by H/D-LC-MS
    Patrick Griffin; Fiscal Year: 2003
    ..M2 proton channel is essential to the infectivity of the virus, and is the target of the anti-influenza drugs, amantadine and rimantadine...
  23. DESIGN OF INFLUENZA VIRUS NEURAMINIDASE INHIBITORS
    Wayne Brouillette; Fiscal Year: 1999
    ..are not effective during a major antigenic variation of influenza, and the only licensed anti-influenza drugs, amantadine and rimantidine, act only against influenza A which quickly becomes resistant...
  24. EFFECTIVE TREATMENTS FOR COCAINE ABUSE AND HIV RISK
    Jeffrey Hoffman; Fiscal Year: 1993
    ..In addition, the effectiveness of the combined use of two antidepressant medications, amantadine and desipramine, will be compared to a placebo for the treatment of cocaine use within each of the three ..
  25. Efficacy of Amantadine Hydochloride after Pediatric TBI
    SUE BEERS; Fiscal Year: 2002
    ..Treatment with amantadine hydrochloride (AMH), a dopamine agonist, has been shown to improve behavioral symptoms and executive function in ..
  26. Amantadine for Arousal in Pediatric TBI: A Pilot Study.
    MARY MC MAHON; Fiscal Year: 2002
    ..The specific aims are: 1) Conduct a trial of amantadine therapy in children who have impaired arousal following TBI, 2) Compare the interrater reliability and validity ..
  27. AMANTADINE FOR TREATMENT OF COCAINE DEPENDENCE
    Leonard Handelsman; Fiscal Year: 1992
    ..Pilot studies using the indirect dopamine agonist, amantadine, support this hypothesis...
  28. STRUCT-BASED DESIGN OF INHIBITORS FOR FLU NEURAMINIDASE
    Y Babu; Fiscal Year: 1991
    ..The only drug currently approved in the U.S. for the prophylaxis and therapy of influenza infection is amantadine hydrochloride. However, mutants resistant to amantadine are readily isolated...
  29. Characterization of the HCV p7 Protein
    Christopher Jones; Fiscal Year: 2009
    ..The HCV p7 protein is a small, integral membrane protein that oligomerizes in vitro to form amantadine sensitive ion channels...
  30. Identification of Novel Influenza Inhibitors
    BENJAMIN DORANZ; Fiscal Year: 2009
    ..The compounds amantadine and rimantadine inhibit M2 and have been used as influenza therapeutics for the past 40 years...
  31. RAPID DETECTION OF INFLUENZA AND PARAINFLUENZA
    Doris Bucher; Fiscal Year: 1993
    ..b>Amantadine can be administered for protection against type A influenza, antivirals are becoming available for treatment of ..
  32. 1 and 2D IR structural analyses of Influenza M2 channel
    MARTIN ZANNI; Fiscal Year: 2006
    ..As such, the emeregence of resistance towards amantadine, one of only two (2) drug classes available against Influenza, is a clear biomedical threat...
  33. Analysis of the Ebola Virus VP24 Channel Protein
    RONALD HARTY; Fiscal Year: 2003
    ..Importantly, the corresponding M2 proton channel of influenza A virus is the target of amantadine. Thus, it is likely that VP24 may serve as a similar target for the rapid development of anti-Ebola virus drugs...
  34. Donepezil HCL: Treating Cognitive Deficit in Autism
    Benjamin Handen; Fiscal Year: 2003
    ....
  35. VIRAL MEMBRANE AND GLYCOPROTEIN STRUCTURE
    Stephen Harrison; Fiscal Year: 2004
    ..Complexes with the inhibitory drug, amantadine, will also be studied.
  36. Identification and Development of Novel Influenza M2 Inhibitors
    BENJAMIN DORANZ; Fiscal Year: 2009
    ..The compounds amantadine and rimantadine inhibit M2 and have been used as influenza therapeutics for the past 40 years...
  37. Novel Chemotypes Against Influenza A Virus
    Maurizio Pellecchia; Fiscal Year: 2007
    ..A (H3N2) virus have specific mutations in the M2 proton channel that result in resistance to the antiviral drug amantadine, one of the very few drugs currently available against the virus...
  38. Transcriptomic Analysis of Therapeutics in Brain Trauma
    C Dixon; Fiscal Year: 2005
    ..to enhance recovery of cognitive function in our experimental model of TBI, and found three to be beneficial: amantadine hydroehloride, bromoeriptine, and methylphenidate...
  39. The gating mechanism of the viral ion channel M2
    JASON SCHNELL; Fiscal Year: 2007
    ..at low pH, (3) look for structural determinants governing the interactions between M2 and the antiviral drug amantadine, and (4) conduct similar studies on the BM2 channel...
  40. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  41. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  42. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  43. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  44. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  45. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  46. Multiple Factors Affecting Placebo Response in PD
    Christopher Goetz; Fiscal Year: 2004
    ..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
  47. PHARMACOLOGIC REHABILITATION OF ATTENTION DEFICITS
    John Whyte; Fiscal Year: 2003
    ..The factor structure will also be compared to that obtained from a control sample. ..
  48. Mechanisms of influenza NA drug resistance
    Jennifer L McKimm Breschkin; Fiscal Year: 2010
    ....
  49. Comparative Study of Influenza Vaccines in Adults
    ARNOLD MONTO; Fiscal Year: 2006
    ..Results will help to determine how the vaccine may be used as part of the strategy to combat influenza in varying situations. [unreadable] [unreadable]..
  50. RUPP-PI Project
    Michael Aman; Fiscal Year: 2006
    ..S.U. also plans two pilot studies: (a) a randomized clinical trial in 60 children with PDDs and severe ADHD behavior and (b) a study of ziprasidone in 30 children and adolescents with PDDs and highly irritable behaviors. ..
  51. Reducing Transmission of Influenza by Face Masks
    ARNOLD MONTO; Fiscal Year: 2008
    ..Such a reduction could have a major public health impact during a pandemic. In the second year, the study can be expanded or modified based on findings in the first. ..
  52. High Throughput Assays for Ion Channel Activities of Influenza A & B Viruses
    LAWRENCE PINTO; Fiscal Year: 2006
    ..The M2 ion channel protein of influenza A virus is the target of the antiviral drug amantadine and the BM2 ion channel protein is a potential target for antiviral drugs because the ion channel activity of ..
  53. RESPIRATORY VIRUS ION CHANNELS
    LAWRENCE PINTO; Fiscal Year: 2007
    ..properties of the channel are essential for its role in the virus life cycle, the functional properties of amantadine-resistant mutant M2 proteins will be characterized. 5...
  54. Topiramate for alcohol and cocaine dependence
    Kyle Kampman; Fiscal Year: 2008
    ..abstract_text> ..
  55. Studies on Influenza B Virus BM2 Protein Ion Channel
    LAWRENCE PINTO; Fiscal Year: 2009
    ..to that of the influenza A virus M2 ion channel protein, the latter being the target of the anti-viral drug amantadine: the drug does not inhibit influenza B virus replication or the BM2 ion channel activity...
  56. Identification of Genetic Modifiers of an Epstein-Barr Virus Protein.
    AMY ADAMSON; Fiscal Year: 2007
    ..Our studies aim to find human genes whose protein products enhance or suppress Epstein-Barr virus protein activity. [unreadable] [unreadable] [unreadable]..
  57. CREATINE THERAPY TO TREAT HUNTINGTON'S DISEASE: A PHASE 3 STUDY
    Steven M Hersch; Fiscal Year: 2010
    ....
  58. GASTROINTESTINAL PEPTIDES AND PANCREATIC CANCER
    Jill Smith; Fiscal Year: 2004
    ..These studies are part of the team's long-term goal to understand the mechanisms involved in the biology of human pancreatic cancer, and contribute to the treatment and early detection of this malignancy. ..
  59. HIV-Hepatitis C Virus Interactions and Pathogenesis
    Raymond T Chung; Fiscal Year: 2010
    ..These studies will shed considerable light on HIV-HCV pathogenic interactions and offer a means of productively disrupting these interactions. ..