perylene

Summary

Summary: A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.

Top Publications

  1. ncbi Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells
    Seyed Mohamed Ali
    Department of Medical Sciences, National Cancer Centre, 11 Hospital Drive, Singapore 169610
    Int J Oncol 21:531-40. 2002
  2. ncbi Vesicular perylene dye nanocapsules as supramolecular fluorescent pH sensor systems
    Xin Zhang
    Universitat Wurzburg, Institut fur Organische Chemie and Rontgen Research Center for Complex Material Systems, Am Hubland, D 97074 Wurzburg, Germany
    Nat Chem 1:623-9. 2009
  3. ncbi Hypericin in cancer treatment: more light on the way
    Patrizia Agostinis
    Division of Biochemistry, Faculty of Medicine, KULeuven, Leuven, Belgium
    Int J Biochem Cell Biol 34:221-41. 2002
  4. pmc Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo
    Rajesh Kumar Gandhirajan
    Department I of Internal Medicine I, University at Cologne, Cologne, Germany
    Neoplasia 12:326-35. 2010
  5. ncbi Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model
    Marie Van De Putte
    Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, University Hospital, K U Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Acad Radiol 15:107-13. 2008
  6. ncbi The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells
    Martina Semeláková
    Institute of Biology and Ecology, Faculty of Sciences, P J Šafárik University in Košice, Moyzesova 11, 040 01 Kosice, Slovakia
    J Photochem Photobiol B 117:115-25. 2012
  7. ncbi Cellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells
    Xiaoli Wang
    School of Applied Chemistry and Biological, Shenzhen Polytechnic, Shenzhen, Guangdong, People s Republic of China
    J Pharmacol Exp Ther 334:847-53. 2010
  8. ncbi High level of low-density lipoprotein receptors enhance hypericin uptake by U-87 MG cells in the presence of LDL
    Slavka Kascakova
    Department of Biophysics, P J Safarik University, Kosice, Slovakia
    Photochem Photobiol 84:120-7. 2008
  9. ncbi Subcellular colocalization of hypericin with respect to endoplasmic reticulum and Golgi apparatus in glioblastoma cells
    Rainer Ritz
    Department of Neurosurgery, Eberhard Karls Universitat Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Anticancer Res 28:2033-8. 2008
  10. ncbi N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage
    Valentina Casagrande
    Dipartimento di Chimica, Università degli Studi La Sapienza, Ple A Moro 5, 00185 Roma, Italy
    J Med Chem 54:1140-56. 2011

Detail Information

Publications292 found, 100 shown here

  1. ncbi Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells
    Seyed Mohamed Ali
    Department of Medical Sciences, National Cancer Centre, 11 Hospital Drive, Singapore 169610
    Int J Oncol 21:531-40. 2002
    ..Our results based on mitochondrial and lysosomal localization support the idea that PDT can contribute to elimination of malignant cells by the induction of apoptosis, and can be of physiological significance...
  2. ncbi Vesicular perylene dye nanocapsules as supramolecular fluorescent pH sensor systems
    Xin Zhang
    Universitat Wurzburg, Institut fur Organische Chemie and Rontgen Research Center for Complex Material Systems, Am Hubland, D 97074 Wurzburg, Germany
    Nat Chem 1:623-9. 2009
    ..Owing to their outstanding optical and redox properties, perylene bisimide chromophores are interesting building blocks for a functional bilayer membrane in a water environment...
  3. ncbi Hypericin in cancer treatment: more light on the way
    Patrizia Agostinis
    Division of Biochemistry, Faculty of Medicine, KULeuven, Leuven, Belgium
    Int J Biochem Cell Biol 34:221-41. 2002
    ..This review focuses on the more recent advances in the use of hypericin as a photodynamic agent and discusses the current knowledge on the signaling pathways underlying its photocytotoxic action...
  4. pmc Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo
    Rajesh Kumar Gandhirajan
    Department I of Internal Medicine I, University at Cologne, Cologne, Germany
    Neoplasia 12:326-35. 2010
    ..We therefore hypothesize that antagonism of lef-1 might lead to killing of CLL cells. We used two small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling (CGP049090 and PKF115-584) to test our hypothesis...
  5. ncbi Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model
    Marie Van De Putte
    Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, University Hospital, K U Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Acad Radiol 15:107-13. 2008
    ..In this preclinical proof-of-principle study, the necrosis avid agent hypericin was investigated as a potential early indicator for therapeutic response after ethanol-mediated chemical ablation in murine liver tumors...
  6. ncbi The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells
    Martina Semeláková
    Institute of Biology and Ecology, Faculty of Sciences, P J Šafárik University in Košice, Moyzesova 11, 040 01 Kosice, Slovakia
    J Photochem Photobiol B 117:115-25. 2012
    ..John's wort, which are increasingly recognized as being able to regulate a variety of pathobiological processes, thus possessing potential therapeutic properties...
  7. ncbi Cellular and molecular mechanisms of photodynamic hypericin therapy for nasopharyngeal carcinoma cells
    Xiaoli Wang
    School of Applied Chemistry and Biological, Shenzhen Polytechnic, Shenzhen, Guangdong, People s Republic of China
    J Pharmacol Exp Ther 334:847-53. 2010
    ..Taken together, both cellular and molecular data revealed that HY-PDT could inhibit the growth of CNE-2 cells and induce their apoptosis...
  8. ncbi High level of low-density lipoprotein receptors enhance hypericin uptake by U-87 MG cells in the presence of LDL
    Slavka Kascakova
    Department of Biophysics, P J Safarik University, Kosice, Slovakia
    Photochem Photobiol 84:120-7. 2008
    ..Both these findings suggest that LDL and LDL receptor-pathway play an important role in the delivery and accumulation of Hyp into the cells...
  9. ncbi Subcellular colocalization of hypericin with respect to endoplasmic reticulum and Golgi apparatus in glioblastoma cells
    Rainer Ritz
    Department of Neurosurgery, Eberhard Karls Universitat Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Anticancer Res 28:2033-8. 2008
    ..Intracellular localization of HYP was investigated by quantitative colocalization analysis with respect to endoplasmic reticulum (ER) and Golgi apparatus (GA) by double staining experiments with fluorescence microscopy...
  10. ncbi N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage
    Valentina Casagrande
    Dipartimento di Chimica, Università degli Studi La Sapienza, Ple A Moro 5, 00185 Roma, Italy
    J Med Chem 54:1140-56. 2011
    A series of bay-substituted perylene derivatives is reported as a new class of G-quadruplex ligands. The synthesized compounds have differing N-cyclic substituents on the bay area and differing side chains on the perylene major axis...
  11. ncbi Evaluation of tumor affinity of mono-[(123)I]iodohypericin and mono-[(123)I]iodoprotohypericin in a mouse model with a RIF-1 tumor
    Humphrey Fonge
    Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, KU Leuven, Herestraat 49, Box 821, B 3000, Leuven
    Contrast Media Mol Imaging 2:113-9. 2007
    ..Mono-[(123)I]iodohypericin appears to be more promising as a tumor diagnostic agent, given its faster clearance from all organs...
  12. ncbi A dual-targeting anticancer approach: soil and seed principle
    Junjie Li
    Department of Radiology, University of Leuven, Campus Gasthuisberg, Herestraat 49, Leuven 3000, Belgium
    Radiology 260:799-807. 2011
    ..To test the hypothesis that targeting the microenvironment (soil) may effectively kill cancer cells (seeds) through a small-molecular weight sequential dual-targeting theragnostic strategy, or dual-targeting approach...
  13. ncbi Molecular imaging of cell death
    Marijke De Saint-Hubert
    Department of Nuclear Medicine, University Hospital Gasthuisberg Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Methods 48:178-87. 2009
    ..As a general conclusion molecular imaging of both apoptosis and necrosis is necessary to understand the cell death process in several pathologies...
  14. ncbi Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT
    Humphrey Fonge
    Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, O and N 2, Box 821, Herestraat 49, BE 3000 Leuven, Belgium
    Eur Heart J 29:260-9. 2008
    ....
  15. doi An improved perylene sensitizer for solar cell applications
    Chen Li
    Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz, Germany
    ChemSusChem 1:615-8. 2008
  16. pmc Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy
    Tilda Barliya
    The Blood Center, Sheba Medical Center, Ramat Gan, Israel
    PLoS ONE 6:e22849. 2011
    The perihydroxylated perylene quinone hypericin has been reported to possess potent anti-metastatic and antiangiogenic activities, generated by targeting diverse crossroads of cancer-promoting processes via unique mechanisms...
  17. ncbi Synthesis and preliminary evaluation of mono-[123I]iodohypericin monocarboxylic acid as a necrosis avid imaging agent
    Humphrey Fonge
    Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, K U Leuven, BE 3000 Leuven, Belgium
    Bioorg Med Chem Lett 17:4001-5. 2007
    ..The results indicate the feasibility of visualization of necrotic tissue with the novel tracer...
  18. pmc New fluorescent perylene bisimide indicators--a platform for broadband pH optodes
    Daniel Aigner
    Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Graz, Austria
    Anal Bioanal Chem 400:2475-85. 2011
    Asymmetric perylene bisimide (PBI) dyes are prepared and are shown to be suitable for the preparation of fluorescence chemosensors for pH...
  19. ncbi Perylene anhydride fused porphyrins as near-infrared sensitizers for dye-sensitized solar cells
    Chongjun Jiao
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543
    Org Lett 13:3652-5. 2011
    Two perylene anhydride fused porphyrins 1 and 2 have been synthesized and employed successfully in dye-sensitized solar cells (DSCs)...
  20. pmc In vitro effects of a small-molecule antagonist of the Tcf/ß-catenin complex on endometrial and endometriotic cells of patients with endometriosis
    Sachiko Matsuzaki
    CHU Clermont Ferrand, CHU Estaing, Chirurgie Gynécologique, 1, Clermont Ferrand, France
    PLoS ONE 8:e61690. 2013
    ..We hypothesized that inhibition of Wnt/ß-catenin signaling might result in inhibition of cell proliferation, migration, and/or invasion of endometrial and endometriotic epithelial and stromal cells of patients with endometriosis...
  21. ncbi Identification of genes differentially expressed in the phytopathogenic fungus Cercospora nicotianae between cercosporin toxin-resistant and -susceptible strains
    Sonia Herrero
    Department of Plant Biology, North Carolina State University, Raleigh, NC, USA
    FEMS Microbiol Lett 275:326-37. 2007
    ..The findings suggest that CRG1 regulates genes involved in pH responses in addition to those involved in toxin resistance and biosynthesis...
  22. ncbi Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model
    Marie Van De Putte
    Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, B 3000 Leuven, Belgium
    Oncol Rep 19:927-32. 2008
    ..The results suggest that hypericin offers significant potential in the early assessment of response following necrosis-inducing antineoplastic treatments such as RFA...
  23. ncbi Lipid-mediated preferential localization of hypericin in lipid membranes
    Yunn Fang Ho
    School of Pharmacy and Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Biochim Biophys Acta 1788:1287-95. 2009
    ..A hypothetical model depicting the intracellular and intravascular co-transport of hypericin and cholesterol because of their high affinity is presented...
  24. ncbi Antibacterial photodynamic therapy using water-soluble formulations of hypericin or mTHPC is effective in inactivation of Staphylococcus aureus
    Victoria Engelhardt
    Department of Molecular Biology, University of Salzburg, Hellbrunnerstrasse 34, 5020, Salzburg, Austria
    Photochem Photobiol Sci 9:365-9. 2010
    ..We suggest both substances as promising candidates for treatment of staphylococcal infections in wounds with APDT...
  25. ncbi Antivascular tumor eradication by hypericin-mediated photodynamic therapy
    Bin Chen
    Laboratorium voor Farmaceutische Biologie en Fytofarmacologie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Leuven, Belgium
    Photochem Photobiol 76:509-13. 2002
    ..Our results strongly suggest that targeting the tumor vasculature by applying short drug-light interval PDT with hypericin might be a promising way to eradicate solid tumors...
  26. pmc Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts
    Junjie Li
    Theranostic Laboratory, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Herestraat 49, Leuven, Belgium
    Theranostics 3:127-37. 2013
    ..Based on the soil-to-seeds principle, we explored the small-molecular sequential dual-targeting theranostic strategy (SMSDTTS) for prolonged survival and imaging detectability in a xenograft tumor model...
  27. ncbi Cell death response of U87 glioma cells on hypericin photoactivation is mediated by dynamics of hypericin subcellular distribution and its aggregation in cellular organelles
    Veronika Huntosova
    Department of Biophysics, University of Pavol Jozef Safarik, Kosice, Slovak Republic
    Photochem Photobiol Sci 11:1428-36. 2012
    ..Such an observation should be taken in consideration for further optimization of Hyp in vivo PDT applications...
  28. ncbi Molecular response to hypericin-induced photodamage
    B Krammer
    University of Salzburg, Department of Molecular Biology, Hellbrunnerstr 34, 5020 Salzburg, Austria
    Curr Med Chem 19:793-8. 2012
    ..The different modes of cellular responses depend mainly on the PDT-protocol, photosensitizer localisation, cellular damage protection and the available intracellular energy...
  29. ncbi The CTB1 gene encoding a fungal polyketide synthase is required for cercosporin biosynthesis and fungal virulence of Cercospora nicotianae
    Mathias Choquer
    Citrus Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, 700 Experiment Station Road, Lake Alfred 33850, USA
    Mol Plant Microbe Interact 18:468-76. 2005
    ..nicotianae. The results also suggest that strategies that avoid the toxicity of cercosporin will be useful in reduction of disease incidence caused by Cercospora spp...
  30. ncbi Exploration of the mechanism underlying the tumor necrosis avidity of hypericin
    Marie Van De Putte
    Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, 3000 Leuven, Belgium
    Oncol Rep 19:921-6. 2008
    ....
  31. ncbi Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells
    E Buytaert
    Department Molecular and Cell Biology, Faculty of Medicine, Catholic University of Leuven, Brabant, Belgium
    Oncogene 27:1916-29. 2008
    ..This analysis identifies new molecular effectors of the cancer cell response to PDT opening attractive avenues to improve the therapeutic efficacy of hypericin-based PDT of bladder cancer...
  32. ncbi The impact of aggregation on the biodistribution of hypericin
    Marie Van De Putte
    Laboratorium voor Farmaceutische Biologie en Fytofarmacologie, Faculteit Farmaceutische Wetenschappen, K U Leuven, B 3000 Leuven, Belgium
    Int J Oncol 28:655-60. 2006
    ..These results may also be extended to radiolabeled derivatives and other lipophilic photosensitizers, such as porphyrins, phthalocyanines, naphthalocyanines and chlorines, with similar aggregation properties...
  33. ncbi Hypericin-based fluorescence diagnosis of bladder carcinoma
    Marie Ange D'Hallewin
    Department of Urology, UZ Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    BJU Int 89:760-3. 2002
    ..To determine the use of hypericin instillation for the fluorescent detection of papillary bladder cancer and carcinoma in situ...
  34. ncbi Photoluminescence and conductivity of self-assembled pi-pi stacks of perylene bisimide dyes
    Zhijian Chen
    Universitat Wurzburg, Institut fur Organische Chemie and Rontgen Research Center for Complex Material Systems, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 13:436-49. 2007
    The self-assembly of a new, highly fluorescent perylene bisimide dye 2 into pi stacks, both in solution and condensed phase, has been studied in detail by NMR spectroscopy, vapor pressure osmometry (VPO), UV/Vis and fluorescence ..
  35. ncbi Kinetics and yield of singlet oxygen photosensitized by hypericin in organic and biological media
    B Ehrenberg
    Department of Chemistry and Biochemistry, University of California, Los Angeles, USA
    Photochem Photobiol 68:135-40. 1998
    ..A strong pH effect was observed, indicating that the deprotonated species formed above about pH 10 is a much weaker photosensitizer of singlet oxygen than the native, protonated species...
  36. ncbi How to make hypericin water-soluble
    A Kubin
    Wiener Gesellschaft für PDD und PDT, Vienna, Austria
    Pharmazie 63:263-9. 2008
    ..Furthermore, hypericin-PVP exhibits high photostability in the presence of oxygen and broad band light which ensures reproducible photodynamic therapy and diagnosis...
  37. ncbi Synthesis and spectroscopic studies of the aminoglycoside (neomycin)--perylene conjugate binding to human telomeric DNA
    Liang Xue
    Laboratories of Medicinal Chemistry, Clemson University, Clemson, South Carolina 29634, United States
    Biochemistry 50:2838-49. 2011
    Synthesis of a novel perylene-neomycin conjugate (3) and the properties of its binding to human telomeric G-quadruplex DNA, 5'-d[AG3(T2AG3)3] (4), are reported...
  38. pmc A single-dose toxicity study on non-radioactive iodinated hypericin for a targeted anticancer therapy in mice
    Jun Jie Li
    Theragnostic Laboratory, Department of Imaging and Pathology, Biomedical Sciences Group, KU Leuven, Belgium
    Acta Pharmacol Sin 33:1549-56. 2012
    ..In the present study, we examined the toxicity of a single dose of non-radioactive (127)I-Hyp in normal mice for 24 h and 14 d...
  39. ncbi Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors
    Thierry Marysael
    Laboratorium voor Farmaceutische Biologie, Faculteit Farmaceutische Wetenschappen, K U Leuven, Herestraat 49 bus 824, 3000 Leuven, Belgium
    J Cancer Res Clin Oncol 137:1619-27. 2011
    ..ZD6126) and sequence of administration (VDA 24 h before HYP vs. HYP 1 h before VDA) to evaluate the effect on hypericin (HYP) accumulation and distribution in necrotic tumors...
  40. ncbi Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo
    Wei Wei
    Asian Liver Center, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5655, USA
    Int J Cancer 126:2426-36. 2010
    ..Our results suggest that these 3 antagonists of the Tcf4/beta-catenin complex are potential chemotherapeutic agents which may offer a pathway specific option for the clinical management of HCC...
  41. ncbi The multifaceted photocytotoxic profile of hypericin
    Theodossis A Theodossiou
    Institute of Physical Chemistry, NCSR Demokritos, Patriarchou Gregoriou and Neapoleos, 15310 Aghia Paraskevi, Attiki, Greece
    Mol Pharm 6:1775-89. 2009
    ..Herein, we aim to integrate the most important findings with regard to hypericin photocytotoxicity, into a unified scenario, detailing its potential in cancer photomedicine...
  42. ncbi Hypericin--the facts about a controversial agent
    A Kubin
    Ludwig Boltzmann Institute for Clinical Oncology and Photodynamic Therapy, Erlgasse 48, 1120 Vienna, Austria
    Curr Pharm Des 11:233-53. 2005
    ..New, although controversial data, over the recent years dictate further research, re-evaluation and discussion of this substance. Our up-to-date summary of hypericin, its activities and potentials, is aimed to contribute to this process...
  43. ncbi The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?
    Hilde Laggner
    Department of Medical Chemistry, Centre of Physiology and Pathophysiology, Medical University Vienna, Vienna, Austria
    Free Radic Res 41:234-41. 2007
    ..5 micromol/l are potent antioxidants in the LDL oxidation systems used. The results indicate that the derivatives found in Hypericum perforatum have possible antiatherogenic potential...
  44. ncbi Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines
    Rainer Ritz
    Department of Neurosurgery, Eberhard Karls Universitat Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Int J Oncol 30:659-67. 2007
    ..These results obtained in cell culture are encouraging and justify further evaluation HY-PDT for the treatment of malignant glioma in animal experiments...
  45. ncbi Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin
    Michael Blank
    Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cancer Res 63:8241-7. 2003
    ..This combination constitutes a mechanism by which hypericin generates mitotic cell death in cancer cells...
  46. ncbi Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells
    Katharina Salome Minke
    Department I of Internal Medicine, University at Cologne, Cologne, Germany
    Eur J Haematol 82:165-75. 2009
    ..This was shown in both, AML cell lines and most of the tested primary samples. Our data demonstrate that targeting this pathway seems to be an innovative approach in the treatment of AML...
  47. pmc A photodynamic pathway to apoptosis and necrosis induced by dimethyl tetrahydroxyhelianthrone and hypericin in leukaemic cells: possible relevance to photodynamic therapy
    G Lavie
    Institute of Hematology, Blood Transfusion Center, Sheba Medical Center, Tel Hashomer, Israel
    Br J Cancer 79:423-32. 1999
    ..Beyond the tolerated levels of photodynamic damage, these cells died exclusively via necrosis. Hut-78 cells overexpress Bcl-X(L) as well as a truncated Bcl-X(L)tr isoform that could contribute to the observed resistance to apoptosis...
  48. ncbi Evidence for kinetic nucleation in helical nanofiber formation directed by chiral solvent for a perylene bisimide organogelator
    Vladimir Stepanenko
    Universitat Wurzburg, Institut für Organische Chemie and Center for Nanosystems Chemistry, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 19:4176-83. 2013
    The self-assembly behavior of an achiral perylene bisimide (PBI) organogelator that bears two 3,4,5-tridodecyloxybenzoylaminoethyl substituents at the imide positions has been investigated in chiral solvents (R)- and (S)-limonene in great ..
  49. ncbi Nanotube surfactant design: the versatility of water-soluble perylene bisimides
    Claudia Backes
    Institute of Advanced Materials and Processes ZMP, University of Erlangen Nuremberg, Dr Mack Str 81, 90762 Fuerth, Germany
    Adv Mater 22:788-802. 2010
    The synthesis of perylene-based single-walled carbon nanotube (SWCNT) surfactants and the dispersion and exfoliation of SWCNTs in water by a variety of designed surfactants is investigated...
  50. ncbi Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells
    Marco Franceschin
    Dipartimento di Chimica, Sapienza Universita di Roma, P le A Moro 5, 00185 Roma, Italy
    ChemMedChem 7:2144-54. 2012
    Based on previous work on both perylene and coronene derivatives as G-quadruplex binders, a novel chimeric compound was designed: N,N'-bis[2-(1-piperidino)-ethyl]-1-(1-piperidinyl)-6-[2-(1-piperidino)-ethyl]-benzo[ghi]perylene-3,4:9,10-..
  51. ncbi First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent
    Yicheng Ni
    Department of Radiology, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 33:595-601. 2006
    ..We have labelled hypericin, a polyphenolic polycyclic quinone found in St. John's wort (Hypericum perforatum), with( 123)I and evaluated mono-[(123)I]iodohypericin (MIH) as a potential necrosis-avid diagnostic tracer agent...
  52. ncbi Study of binding affinity and selectivity of perylene and coronene derivatives towards duplex and quadruplex DNA by ESI-MS
    Valentina Casagrande
    Dipartimento di Chimica, Sapienza Universita di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy
    J Mass Spectrom 44:530-40. 2009
    ..noncovalent interactions between different intermolecular and intramolecular G-quadruplex structures and several perylene and coronene ligands...
  53. ncbi Accumulation and interaction of hypericin in low-density lipoprotein--a photophysical study
    Prasun Mukherjee
    Department of Chemistry, Iowa State University, Ames, IA, USA
    Photochem Photobiol 84:706-12. 2008
    ..The results demonstrate the ability of LDL to solubilize hypericin (a known photosensitizer) in nonaggregated form, which has implications for the construction of drug delivery systems...
  54. ncbi Perylene imides for organic photovoltaics: yesterday, today, and tomorrow
    Chen Li
    Max Planck Institute for Polymer Research, Ackermannweg 10, D 55128 Mainz, Germany
    Adv Mater 24:613-36. 2012
    b>Perylene imides have been an object of research for 100 years and their derivatives are key n-type semiconductors in the field of organic electronics...
  55. ncbi Evidence for intracellular aggregation of hypericin and the impact on its photocytotoxicity in PAM 212 murine keratinocytes
    Theodossis Theodossiou
    National Medical Laser Centre, Royal Free and University College Medical School, Academic Division of Surgical Specialties, University College London, London, UK
    Photochem Photobiol 80:438-43. 2004
    ....
  56. ncbi Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer
    Hongyan Du
    Department of Anatomy, National University of Singapore, Singapore 169610
    Cancer Lett 235:202-8. 2006
    ..In conclusion, the study elucidated that the cell type, degree of histological differentiation and the basal expression of the cytokine influence the cytokine response following PDT...
  57. ncbi Selective enrichment of hypericin in malignant glioma: pioneering in vivo results
    Susan Noell
    Department of Neurosurgery, Eberhard Karls Universitat Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    Int J Oncol 38:1343-8. 2011
    ..To the best of our knowledge, the present study demonstrates for the first time that hypericin accumulates selectively in intracerebral implanted C6 glioma in vivo after systemic (intravenous) administration...
  58. ncbi Syntheses and properties of 1,6 and 1,7 perylene diimides and tetracarboxylic dianhydrides
    Nisha V Handa
    Department of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, Oklahoma 74074, USA
    Org Lett 13:4724-7. 2011
    Via Sonogashira cross-coupling with different alkynes, 1,6 and 1,7 perylene diimides (PDIs) and perylene tetracarboxylic dianhydrides (PTCDs) were synthesized from the corresponding regioisomeric mixture of 1,6/1,7-dibromo precursors...
  59. ncbi Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model
    B Chen
    Laboratorium voor Farmaceutische Biologie en Fytofarmacologie, Faculteit Farmaceutische Wetenschappen, K.U. Leuven, Van Evenstraat 4, B-3000 Leuven, Belgium
    Int J Cancer 93:275-82. 2001
    ..Hypericin distribution and PDT response studies revealed a close correlation between the plasma drug level and the PDT effects, which suggests that vascular damage is the primary effect of hypericin-mediated PDT in this tumor model...
  60. ncbi Hypericin in the dark inhibits key steps of angiogenesis in vitro
    Beatriz Martínez-Poveda
    Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Universidad de Malaga, Campus de Teatinos, 29071 Malaga, Spain
    Eur J Pharmacol 516:97-103. 2005
    ....
  61. ncbi Down-regulation of the human VEGF gene expression by perylene monoimide derivatives
    Thanachai Taka
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    Bioorg Med Chem Lett 22:518-22. 2012
    ..In this study, we compared two perylene monoimide derivatives, PM1 and PM2, with the well-studied perylene diimide derivative, PIPER, and the well-..
  62. ncbi A phase II placebo-controlled study of photodynamic therapy with topical hypericin and visible light irradiation in the treatment of cutaneous T-cell lymphoma and psoriasis
    Alain H Rook
    University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Am Acad Dermatol 63:984-90. 2010
    ....
  63. pmc Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma
    Kumar Sukhdeo
    Department of Medical Oncology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:7516-21. 2007
    ..Taken together, these data demonstrate the efficacy of disrupting the beta-catenin/TCF transcriptional complex to exploit tumor dependence on Wnt signaling as a therapeutic approach in the treatment of MM...
  64. ncbi In vitro accumulation and permeation of hypericin and lipophilic analogues in 2-D and 3-D cellular systems
    Ivo Crnolatac
    Laboratorium voor Farmaceutische Biologie, Faculteit Farmaceutische Wetenschappen, Leuven, Belgium
    Int J Oncol 30:319-24. 2007
    ..The findings further highlight AM8 and AM12 as compounds better tailored for paracellular transport than HYP itself and therefore as potentially very interesting diagnostic tools for TCC lesions in the bladder...
  65. ncbi Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway
    S H Cherng
    Institute of Toxicology, Chung Shan Medical and Dental College, Taichung, Republic of China
    Toxicol Appl Pharmacol 170:63-8. 2001
    Although benzo[g,h,i]perylene (BghiP) has been found to promote the carcinogenesis of benzo[a]pyrene (BaP) in animal models, not much is known about this cocarcinogenic mechanism...
  66. ncbi Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models
    Qingyu Zhou
    Laboratory of Clinical Pharmacology Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, 11, Hospital Drive, 169610, Singapore
    Cancer Chemother Pharmacol 56:569-77. 2005
    ..Photodynamic therapy (PDT) is a promising therapeutic modality using a tumor localizing photosensitizer and light to destroy tumor cells. A major limitation of PDT is tumor recurrence, which is partly due to neovascularization...
  67. ncbi Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro
    Rainer Ritz
    Department of Neurosurgery, Eberhard Karls University, University Hospital Tuebingen, 72076 Tuebingen, Germany
    Int J Oncol 27:1543-9. 2005
    ..0001). Therefore, hypericin seems to be a promising substance for the photodynamic therapy of malignant brain tumors...
  68. ncbi Detection of hypericins in the "red glands" of Hypericum elodes by ESI-MS/MS
    Anna Piovan
    Department of Biology, Padua University, Via U Bassi 58 B, 35131 Padua, Italy
    Phytochemistry 65:411-4. 2004
    ..The biologically active phloroglucinol derivatives hyperforin and adhyperforin, so far found only in H. perforatum, were also detected and evidence for their localization in the sepal secretory canals with large lumen, is given...
  69. ncbi Cellular mechanisms and prospective applications of hypericin in photodynamic therapy
    Tobias Kiesslich
    Department of Molecular Biology, University of Salzburg, Austria
    Curr Med Chem 13:2189-204. 2006
    ....
  70. pmc Interactions of a platinum-modified perylene derivative with the human telomeric G-quadruplex
    Lu Rao
    Department of Chemistry, Wake Forest University, Winston Salem, North Carolina 27109, USA
    J Phys Chem B 115:13701-12. 2011
    The interactions of a newly synthesized platinum-modified perylene derivative, compound 7 ([{Pt(dien)}(2)(μ-4-S,S')](NO(3))(4) (dien = diethylenetriamine, 4 = N,N'-bis(1-(2-aminoethyl)-1,3-dimethylthiourea)-3,4,9,10-..
  71. ncbi Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase
    Danilo D'Ambrosio
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Frontiers in Genetics National Center of Competence in Research, Ecole Polytechnique Federale de Lausanne, Station 19, 1015 Lausanne, Switzerland
    Biochimie 94:854-63. 2012
    ..quantitative direct telomerase activity assays to evaluate the strength and mechanism of action of hydrosoluble perylene diimides (HPDIs). HPDIs contain a perylene moiety and different numbers of positively charged side chains...
  72. ncbi Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines
    A B Uzdensky
    Department of Biophysics and Biocybernetics, Rostov State University, 194 1 Stachky ave, Rostov on Don 344090, Russia
    Lasers Med Sci 16:276-83. 2001
    ..Hypericin concentrations of 10 microM or less were not toxic for WiDr cells in the dark. Orange light (lambda max approximately 600 nm; 6 mW/cm2) killed the cells stained with 1 microM hypericin with LD50 approximately 1 J/cm2...
  73. ncbi G-quadruplex DNA cleavage preference and identification of a perylene diimide G-quadruplex photocleavage agent using a rapid fluorescent assay
    Michelle Schoonover
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA
    Bioorg Med Chem 20:6904-18. 2012
    ..Finally, this assay was used to identify the perylene diimide Tel11 as a photocleavage agent for the c-Myc G-quadruplex.
  74. ncbi Photodynamic therapy using topically applied hypericin: comparative effect with methyl-aminolevulinic acid on UV induced skin tumours
    A Boiy
    Faculty of Pharmaceutical Sciences, KU Leuven, Leuven, Belgium
    J Photochem Photobiol B 102:123-31. 2011
    ..Full lesional necrosis was observed in responsive lesions, and the atypical cells of actinic keratosis were replaced by normal keratinocytes 3 weeks later, both after hypericin-PDT and Me-ALA-PDT...
  75. ncbi Functional expression and cellular localization of cercosporin-resistance proteins fused with the GFP in Cercospora nicotianae
    Kuang Ren Chung
    Department of Plant Pathology, North Carolina State University, Raleigh 27695 7616, USA
    Curr Genet 41:159-67. 2002
    ....
  76. ncbi [Quantitative analysis of active substances in St. John's wort (Hypericum perforatum L.) by the high performance liquid chromatography method]
    Saulius Kazlauskas
    Kaunas University of Medicine, A Mickeviciaus 9, 44307 Kaunas, Lithuania
    Medicina (Kaunas) 40:975-81. 2004
    ..The quantitative variation of active substances in different habitats allows the selection of the best plant samples for their cultivation and conservation in field collections...
  77. ncbi The correlation between hydrophilicity of hypericins and helianthrone: internalization mechanisms, subcellular distribution and photodynamic action in colon carcinoma cells
    Galit Siboni
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Photochem Photobiol Sci 1:483-91. 2002
    ....
  78. ncbi Manipulating single-wall carbon nanotubes by chemical doping and charge transfer with perylene dyes
    Christian Ehli
    Friedrich Alexander Universitat Erlangen Nurnberg, Department of Chemistry and Pharmacy and Interdisciplinary Center for Molecular Materials, Egerlandstrasse 3, 91058 Erlangen, Germany
    Nat Chem 1:243-9. 2009
    ..the complete and thorough characterization of an SWNT radical ion-pair state induced by complexation with a perylene dye, which combines excellent electron-accepting and -conducting features with a five-fused ring π-system...
  79. ncbi Hypericin as novel and promising photodynamic therapy tool: studies on intracellular accumulation capacity and growth inhibition efficiency
    Zivile Luksiene
    Institute of Material Science and Applied Research, Vilnius University, Sauletekio 9, 2040 Vilnius, Lithuania
    Medicina (Kaunas) 39:677-82. 2003
    ..Hence, the accumulation of the photosensitizer in the tumor cells should be considered as one of the prognostic factors for the determination of the therapeutic outcome...
  80. ncbi Synthesis of hydroxy and methoxy perylene quinones, their spectroscopic and computational characterization, and their antiviral activity
    G Krishnamoorthy
    Department of Chemistry, Iowa State University, Ames, IA 50011, USA
    Photochem Photobiol 81:924-33. 2005
    Hydroxy and methoxy perylene quinones are synthesized in an attempt to isolate the essential spectroscopic and biological features of light-induced antiviral agents such as hypericin and hypocrellin...
  81. ncbi The influence of pH on the G-quadruplex binding selectivity of perylene derivatives
    Wirote Tuntiwechapikul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiangmai 50200, Thailand
    Bioorg Med Chem Lett 16:4120-6. 2006
    Three new perylene derivatives with branched ionizable side chains were synthesized, and their G-quadruplex binding specificities were compared by spectroscopic and electrophoretic analysis with two well-studied G-quadruplex ligands: ..
  82. ncbi Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells
    C Hadjur
    laboratorie de Biochimie C, Centre Hospitalier Régional Universitaire A Michallon, Grenoble, France
    Photochem Photobiol 64:375-81. 1996
    ..It can be inferred that (a) HYP may be an effective PDT agent for melanoma and (b) there is a relationship between melanin content and sensitivity to HYP phototoxicity in human melanoma cells...
  83. ncbi Water soluble cationic perylene derivatives as possible telomerase inhibitors: the search for selective G-quadruplex targeting
    Emanuela Micheli
    Dipartimento di Chimica, Sapienza Universita di Roma, Roma, Italy
    Mini Rev Med Chem 9:1622-32. 2009
    ..Here, we mean to critically analyze the class of hydrosoluble perylene di-imides (HPDIs), which offers the intriguing possibility to fix the hydrophobic molecule moiety (perylene) able ..
  84. ncbi Pathway-dependent self-assembly of perylene diimide/peptide conjugates in aqueous medium
    Yaron Tidhar
    Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Chemistry 17:6068-75. 2011
    ..We demonstrate that well-defined amphiphilic molecular systems based on perylene diimide/peptide conjugates exhibit kinetically controlled self-assembly in aqueous medium, enabling pathway-..
  85. ncbi Perylene-conjugated pyrrole polyamide as a sequence-specific fluorescent probe
    Jun Fujimoto
    Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa Oiwakecho, Sakyo, Kyoto 606 8502, Japan
    Bioorg Med Chem 16:9741-4. 2008
    b>Perylene-conjugated pyrrole (Py)-polyamide 2 was designed and synthesized using the Fmoc solid-phase synthesis and a subsequent Sonogashira coupling reaction with 3-bromoperylene...
  86. ncbi Biodistribution and photodynamic effects of polyvinylpyrrolidone-hypericin using multicellular spheroids composed of normal human urothelial and T24 transitional cell carcinoma cells
    Joachim Vandepitte
    Katholieke Universiteit Leuven, Faculteit Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Biologie, B 3000 Leuven, Belgium
    J Biomed Opt 16:018001. 2011
    ....
  87. ncbi Anti-cancer activities of hypericin in the dark
    M Blank
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Photochem Photobiol 74:120-5. 2001
    ....
  88. ncbi Potentiation of the photodynamic action of hypericin
    Constance Lay Lay Saw
    Department of Pharmacy, National University of Singapore, Singapore 117543
    J Environ Pathol Toxicol Oncol 27:23-33. 2008
    ..Hyperoxygenation and hyperthermia can also be used to further enhance the efficacy of HY-PDT...
  89. ncbi Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model
    Constance Lay Lay Saw
    Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
    J Photochem Photobiol B 86:207-18. 2007
    ..The NMP formulations investigated were able to produce significantly higher contrast for tumor tissues and at earlier time points than was possible with HY-HSA 0.5%...
  90. ncbi Human serum albumin as key mediator of the differential accumulation of hypericin in normal urothelial cell spheroids versus urothelial cell carcinoma spheroids
    Mieke Roelants
    Laboratorium voor Farmaceutische Biologie, Katholieke Universiteit Leuven, Herestraat 49, B 3000, Leuven, Belgium
    Photochem Photobiol Sci 10:151-9. 2011
    ....
  91. ncbi Microscopic quantification of hypercin fluorescence in an orthotopic rat bladder tumor model after intravesical instillation
    Appolinary A R Kamuhabwa
    Laboratorium voor Farmaceutische Biologie en Fytofarmacologie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Oncol 22:933-7. 2003
    ..The results suggest that under these conditions, PDT with hypericin is likely to produce uniform urothelial tumor eradication, without causing damage to the underlying muscle layers...
  92. pmc Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions
    P S P Thong
    Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore
    Br J Cancer 101:1580-4. 2009
    ..We present clinical data on fluorescence diagnostic imaging of oral lesions using hypericin, a plant-based photosensitiser...
  93. ncbi Delivery of hypericin for photodynamic applications
    Constance Lay Lay Saw
    Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore, Singapore 117543
    Cancer Lett 241:23-30. 2006
    ....
  94. ncbi {beta}-Catenin regulates airway smooth muscle contraction
    Sepp R Jansen
    Dept of Molecular Pharmacology, Univ of Groningen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 299:L204-14. 2010
    ....
  95. ncbi Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences
    Claudia Pivetta
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5 35131 Padova, Italy
    Bioorg Med Chem 16:9331-9. 2008
    The stabilisation of different G-quadruplex intra- and intermolecular structures by a number of perylene derivatives characterised by side chains ending with linear or cyclic amines was investigated by electrophoretic (EMSA) and ..
  96. ncbi Determining hyperforin and hypericin content in eight brands of St. John's wort
    Gerlie C de los Reyes
    School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Am J Health Syst Pharm 59:545-7. 2002
  97. ncbi Spectroscopic characterization and photobleaching kinetics of hypericin-N-methyl pyrrolidone formulations
    Constance Lay Lay Saw
    Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore, Singapore 117543
    Photochem Photobiol Sci 5:1018-23. 2006
    ..The photobleaching of HY in these formulations followed first-order kinetics. The loss of fluorescence paralleled to the loss of absorption of HY. The formulation of HY with 40% NMP was found to be the most stable...
  98. ncbi Permeation of hypericin in spheroids composed of different grade transitional cell carcinoma cell lines and normal human urothelial cells
    Ann Huygens
    Laboratorium voor Farmaceutische Biologie en Fytofarmacologie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Leuven, Belgium
    J Urol 174:69-72. 2005
    ..We investigated the importance of E-cadherin expression on the selective accumulation of hypericin in superficial bladder cancer after intravesical instillation...
  99. ncbi Pyrene-perylene as a FRET pair coupled to the N2'-functionality of 2'-amino-LNA
    Dorthe Lindegaard
    Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Bioorg Med Chem 16:94-9. 2008
    ....
  100. ncbi Water-soluble rylene dyes as high-performance colorants for the staining of cells
    Tanja Weil
    Max Planck Institut fur Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany
    Biomacromolecules 6:68-79. 2005
    The synthesis of perylene and terrylene chromophores carrying a single poly(ethylene oxide) chain is presented...
  101. ncbi Perylene derivatives produced by Alternaria alternata, an endophytic fungus isolated from Laurencia species
    Shu Shan Gao
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
    Nat Prod Commun 4:1477-80. 2009
    Two new perylene derivatives, 7-epi-8-hydroxyaltertoxin I (1) and 6-epi-stemphytriol (2), along with two known compounds stemphyperylenol (3) and altertoxin I (4) were isolated from Alternaria alternata, a marine endophytic fungus derived ..

Research Grants9

  1. Sulfatase Activated Fluorescent Probes for In Vivo Diagnostic Imaging of Cancer
    KIMBERLY ELIZABETH BEATTY; Fiscal Year: 2010
    ..hydrolyzable fluorophore scaffolds will be evaluated, including sulfated dimethylacridinones, resorufins, perylene diones, and luminogenic coumarin-lanthanide conjugates...
  2. PORPHYRIN SYNTHETIC METHODS FOR BIOORGANIC APPLICATIONS
    JONATHAN LINDSEY; Fiscal Year: 2007
    ....
  3. Stable cationic bacteriochlorins for antimicrobial photodynamic therapy
    JONATHAN LINDSEY; Fiscal Year: 2008
    ..The two best performing bacteriochlorins will then be tested in a mouse model of a potentially lethal wound infection and monitored by bioluminescence imaging. [unreadable] [unreadable] [unreadable]..
  4. CYTOKINE THERAPY OF CUTANEOUS T CELL LYMPHOMA
    Alain Rook; Fiscal Year: 2004
    ..abstract_text> ..
  5. Quantifying Biosynthesized Porphyrins and Complexes
    MARK SCHLAUTMAN; Fiscal Year: 2004
    ..The CL detection systems developed for ion-pair HPLC in this project will ultimately find use as powerful new detection systems for micro-chip, nano-chip, and microarray applications. ..
  6. Recombinant Interleukin-12 for Cutaneous T-Cell Lymphoma
    Alain Rook; Fiscal Year: 2006
    ..Moreover, the addition of low-dose IL-2 may yield a more efficacious combination of agents which may synergistically enhance anti-tumor immunity and clinical responses. ..
  7. Dendritic cell defects in cutaneous T-cell lymphoma
    Alain Rook; Fiscal Year: 2007
    ..abstract_text> ..
  8. Nano Accordions for Probing Biomolecular Interactions
    Alexander Li; Fiscal Year: 2007
    ..Our long-term objectives are to use these molecular accordions to probe regulatory events in vivo and to further our understanding of abnormal cell transformations underlying molecular mechanism of diseases. ..
  9. CYTOMIMETIC ORGANIC CHEMISTRY
    FREDRIC MENGER; Fiscal Year: 2007
    ....